5. Consent

5.1 Capacity to Consent

Consent to enter this study must be sought from each participant only after a full explanation of the trial, its objectives and risks, the assessments and timing of assessments, an information leaflet and time allowed for consideration etc, has been provide to the participant. Signed consent forms must be obtained. The right of the subject to refuse to participate without giving reasons must be respected.

Patients must retain the capacity to provide written consent for repeat procedures throughout the study duration.

All patients must be capable of providing informed consent to participate in this study. Written consent must be obtained from all participants by the study investigator.

 5.2 Consent Forms

Consent will comprise of 4 separate consent forms for each of the following aspects of the study:

Consent Form 1
Use of relevant clinical notes and results from their routine clinical assessments, along with supplementary neuropsychological testing as necessary. [Appendix A]

Consent Form 2
Venepuncture for genotyping for Apolipoprotein E (APOE). [Appendix B]

Consent Form 3
Venepuncture for blood biomarker analysis and measurement of albumin. [Appendix C]

Consent Form 4
Lumbar puncture (LP) for cerebrospinal fluid (CSF) biomarker analysis. [Appendix D]