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Michael O'Sullivan
Associate Professor, Dental Science

Biography

Michael O'Sullivan qualified in dentistry from Trinity College Dublin in 1990. After a time in general dental practice he completed a MSc in Conservative Dentistry at the Eastman Dental Institute and University of London and fellowships from the Royal College of Surgeons in Ireland and Edinburgh (FFD RCSI and FDS RCS(Ed)). He then undertook specialist training in Restorative Dentistry at the Dublin Dental School and Hospital, completing training in 1998 and his Intercollegiate Specialist Fellowship Examination from the RCSI. He also completed a PhD in Biochemistry at Trinity College with Professor Keith Tipton entitled "Semicarbazide-sensitive Amine Oxidase in Human and Porcine Dental Pulp" graduating in 2001. From 1999-2001 he completed a Research Fellowship with Dr Mary McDougall and a Clinical Fellowship with Dr Robert Cronin, both at the University of Texas Health Science Centre at San Antonio, Texas. He returned to Ireland in 2001 and was appointed a Senior Lecturer /Consultant in Restorative Dentistry (Special Dental Needs) in the Division of Restorative Dentistry and Periodontology at the Dublin Dental School and Hospital, Trinity College Dublin.

Publications and Further Research Outputs

Peer-Reviewed Publications

Michael Crowe , Michael O' Sullivan, Oscar Cassetti and Aifric O' Sullivan, Weight Status and Dental Problems in Early Childhood: Classification Tree Analysis of a National Cohort. , Dent. J. , 5, (3), 2017, p25- Journal Article, 2017

Michael O'Sullivan, Brian C O'Connell, Multidisciplinary management of hypodontia , Prim Dent J, 6, (1), 2017, p62 - 73 Journal Article, 2017

McMANUS BA, O'CONNOR AM, KINNEVEY PM, O'SULIVAN M, POLYZOIS I, COLEMAN DC, FIRST DETAILED CHARACTERIZATION OF THE STRUCTURAL ORGANIZATION OF TYPE III ARGININE CATABOLIC MOBILE ELEMENTS (ACMEs) HARBORED BY STAPHYLOCOCCIS EPIDERMIDIS BY WHOLE GENOME SEQUENCING, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 61, (10), 2017, p1-5:e01216-17 Journal Article, 2017 DOI URL TARA - Full Text

Crowe, M., O'Sullivan, M., Cassetti, O., McGrath, C., O'Sullivan, A. , Data mapping to augment dietary intake values from a nutritional database to a national cohort survey: protocols to improve quality of reported food intake, Proceedings of the Nutrition Society, 75, (OCE3), 2016, pdoi: 10.1017/S0029665116002032 Journal Article, 2016

Crowe, M., O'Sullivan, A., McGrath, C., Cassetti, O., Swords, L., & O'Sullivan, M. , Early Childhood Dental Problems: Classification Tree Analyses of 2 Waves of an Infant Cohort Study. , JDR Clinical & Translational Research, 1, (3), 2016, p275 - 284 Journal Article, 2016

Nayyar J, Clarke M, O'Sullivan M, Stassen LF, Fractured root tips during dental extractions and retained root fragments. A clinical dilemma?, British dental journal, 218, (5), 2015, p285-90 Journal Article, 2015 DOI

Hashem A, Kelly A, O'Connell B, O'Sullivan M, Impact of moderate and severe hypodontia and amelogenesis imperfecta on quality of life and self-esteem of adult patients., Journal of dentistry, 41, (8), 2013, p689-94 Journal Article, 2013

MacCarthy D, Nunn J, Healy CM, Stassen LF, Gorman T, Martin B, Toner M, Clarke M, Dougall A, McLoughlin J, Kelly A, Waldron C, O'Sullivan M, Doyle C, Flint S, Outcomes from the first mouth cancer awareness and clinical check-up day in the Dublin Dental University Hospital., Journal of the Irish Dental Association, 58, (2), 2012, p101-8 Journal Article, 2012

MacCarthy D, O'Sullivan E, McAlister C, Healy CM, Flint S, Toner M, Nunn J, Allen F, Gorman T, O'Sullivan M, Stassen LF, The development of mouth, head and neck cancer awareness in Ireland and results of Mouth Cancer Awareness Day 2011., Journal of the Irish Dental Association, 58, (2), 2012, p109-13 Journal Article, 2012

McSharry D, O'Connor C, McNicholas T, Langran S, O'Sullivan M, Lowery M, McNicholas WT, Genioglossus fatigue in obstructive sleep apnea., Respiratory physiology & neurobiology, 183, (2), 2012, p59-66 Journal Article, 2012

Sharkey S, Kelly A, Houston F, O'Sullivan M, Quinn F, O'Connell B, A radiographic analysis of implant component misfit., The International journal of oral & maxillofacial implants, 26, (4), 2011, p807-15 Journal Article, 2011

Canning T, O'Connell BC, Houston F, O'Sullivan M, The effect of skeletal pattern on determining articulator settings for prosthodontic rehabilitation: an in vivo study., The International journal of prosthodontics, 24, (1), 2011, p16-25 Journal Article, 2011

RENTZIA A, COLEMAN DC, O'DONNELL MJ, DOWLING AH, O'SULLIVAN M, DISINFECTION PROCEDURES: THEIR EFFICACY AND EFFECT ON DIMENSIONAL ACCURACY, SURFACE QUALITY AND SURFACE DETAIL REPRODUCTION OF AN IRREVERSIBLE HYDROCOLLOID IMPRESSION MATERIAL, JOURNAL OF DENTISTRY, 39, (2), 2011, p133 - 140 Journal Article, 2011 TARA - Full Text

Brennan M, Houston F, O'Sullivan M, O'Connell B, Demographics of implant placement and complications of a patient subgroup in a dental hospital population., Journal of the Irish Dental Association, 56, (2), 2010, p85-92 Journal Article, 2010

Brennan M, Houston F, O'Sullivan M, O'Connell B, Patient satisfaction and oral health-related quality of life outcomes of implant overdentures and fixed complete dentures., The International journal of oral & maxillofacial implants, 25, (4), 2010, p791-800 Journal Article, 2010

Atef A. Hashem, Brian O'Connell, June Nunn, Anne O'Connell, Therese Garvey, Michael O'Sullivan, Tooth agenesis in patients referred to an Irish tertiary care clinic for the developmental dental disorders, Journal of the Irish Dental Association, 56, (1), 2010, p23 - 27 Journal Article, 2010 TARA - Full Text

Fitzgerald M, O'Sullivan M, O'Connell B, Houston F, Accuracy of bone mapping and guided flapless implant placement in human cadavers using a model-based planning procedure., The International journal of oral & maxillofacial implants, 25, (5), 2010, p999-1006 Journal Article, 2010

Condon M, Bready M, Quinn F, O'Connell BC, Houston FJ, O'Sullivan M, Maxillary anterior tooth dimensions and proportions in an Irish young adult population., Journal of oral rehabilitation, 2010 Journal Article, 2010 DOI

Nomenclature and Potential Functions of Copper Amine Oxidases in, editor(s)Giovanni Floris and Bruno Mondovi , Copper Amine Oxidases: Structures, Catalytic Mechanisms and Role in Pathophysiology, CRC Press, 2009, [S. Boyce, K. F. Tipton, M. I. O'Sullivan, G. P. Davey, M. Motherway Gildea, A. G. McDonald, A. Olivieri, and J. O'Sullivan] Book Chapter, 2009

Sharkey S, Chaollai AN, O'Sullivan M., A review of aggressive periodontitis and an associated case report., Dental Update, 36, (1), 2009, p38 - 50 Journal Article, 2009

Olivieri A, Davey G, O'Sullivan M I, Tipton K F, Boyce S, McDonald A G, O'Sullivan J. , What might amine oxidase recognise? , Proceedings of the 2nd European Conference on Chemistry for Life Sciences. , 2008, 2008, pp51 - 57 Conference Paper, 2008

Canning T, O'Sullivan M. , Acrylic resin jigs as a guide to parallel guiding plane preparation., J Prosthet Dent , 99, 2008, p162 - 164 Journal Article, 2008

Duggan D, Quinn F, O'Sullivan M. , A long-term follow up of spontaneously healed root fractures later subjected to orthodontic forces - two case reports. , Dental Traumatology, Online Early Artic, (doi:10.1111/j.1600-9), 2008 Journal Article, 2008

Freedman M, Quinn F and O'Sullivan M, Single Unit CAD/CAM Restorations: A Lierature review, Irish Dental Journal, 53, (1), 2007, p38 - 45 Journal Article, 2007

O'Connor, C. M.; der van Merwe, L.; Langran, S.; O'Sullivan, M.; Nolan, P.; Vaughan, C. L.; O'Malley, M. J.;, Design of Surface Electrode Array for Measuring Conduction Velocity in the Human Genioglossus Muscle, IEEE Transactions on Biomedical Engineerin, 54, (2), 2007, p335 - 339 Journal Article, 2007

O'Sullivan J, O'Sullivan M, Tipton K F, Unzeta M, Hernandez M, Davey G. , Hydrogen peroxide derived from amine oxidation mediates the interaction between aminosugars and semicarbazide-sensitive amine oxidase. , Journal of Neural Transmission, 114, (Suppl), 2007, p751 - 756 Journal Article, 2007

O'Connell B, O'Sullivan M. , Have teeth will travel: dental tourism--informing the public., J Ir Dent Assoc., 53, (4), 2007, p180 - 182 Journal Article, 2007

J O'Sullivan, G Davey, M O'Sullivan, KF Tipton, Hydrogen peroxide derived from amine oxidation mediates the interaction between aminosugars and semicarbazide-sensitive amine oxidase, J Neural Transm, 2007 Journal Article, 2007

Brennan M, O'Connell B, O'Sullivan M, Multiple dental fractures following tongue barbell placement: a case report, Dent Traumatol., 22, (1), 2006, p41 - 43 Journal Article, 2006

O'Sullivan J, O'Sullivan M.I, Tipton K F, Davey G. , Inhibition of amine oxidases by the histamine-1 receptor antagonist hydroxyzine. , Jouirnal of neural Transmission, 71, (Suppl), 2006, p105 - 112 Journal Article, 2006

Resin Bonded Restorations in, editor(s)Michael O'Sullivan , Fixed Prosthodontics in Dental Practice, London, Quintessence Publishing Co. Ltd., 2005, pp129 - 138, [Michael O'Sullivan] Book Chapter, 2005

Patient Assessment and Presentation of Treatment Options in, editor(s)Michael O'Sullivan , Fixed Prosthodontics in Dental Practice, London, Quintessence Publishing Co. Ltd., 2005, pp1 - 15, [Michael O'Sullivan & Edward G. Ownes] Book Chapter, 2005

Objectives of Tooth Preparation in, editor(s)Michael O'Sullivan , Fixed Prosthodontics in General Practice, 2005, Quintessence Publishing Co. Ltd., 2005, pp15 - 24, [Edward G Owens & Michael O'Sullivan] Book Chapter, 2005

Michael O'Sullivan, Fixed Prosthodontics in Dental Practice, 1st Edition, London, Quintessence Publishing Co. Ltd., 2005, 1 - 162pp Book, 2005

Evaluation of Completed Restorations in, editor(s)Michael O'Sullivan , Fixed Prosthodontics in Dental Practice, 2005, Quintessence Publishing Co. Ltd., 2005, pp101 - 112, [Michael O'Sullivan] Book Chapter, 2005

O'Sullivan M, Hansen N, Cronin RJ, Cagna DR, The hollow maxillary complete denture: a modified technique, J Prosthet Dent., 91, (6), 2004, p591 - 594 Journal Article, 2004

O'Sullivan J, Unzeta M, Healy J, O'Sullivan MI, Davey G, Tipton KF, Semicarbazide-sensitive amine oxidases: enzymes with quite a lot to do, Neurotoxicology, 25, (1-2), 2004, p303 - 315 Journal Article, 2004

O'Sullivan J, O'Sullivan M, Tipton KF, Unzeta M, Del Mar Hernandez M, Davey GP, The inhibition of semicarbazide-sensitive amine oxidase by aminohexoses, Biochim Biophys Acta., 1647, (1-2), 2003, p367 - 371 Journal Article, 2003

Tipton KF, O'Sullivan MI, Davey GP, O'Sullivan J, It can be a complicated life being an enzyme, Biochem Soc Trans., 31, (Pt 3), 2003, p711 - 715 Journal Article, 2003

O'Sullivan M, MacDougall MB, Unzeta M, Lizcano JM, Tipton KF, Semicarbazide-sensitive amine oxidases in pig dental pulp, Biochim Biophys Acta., 1647, (1-2), 2003, p333 - 336 Journal Article, 2003

O'Sullivan M, Tipton KF, McDevitt WE, Immunolocalization of semicarbazide-sensitive amine oxidase in human dental pulp and its activity towards serotonin, Arch Oral Biol., 47, (5), 2002, p399 - 406 Journal Article, 2002

Unterbrink A, O'Sullivan M, Chen S, MacDougall M, TGF beta-1 downregulates DMP-1 and DSPP in odontoblasts, Connect Tissue Res., 43, (2-3), 2002, p354 - 358 Journal Article, 2002

Quinlan CA, Zisterer DM, Tipton KF, O'Sullivan MI, In vitro cytotoxicity of a composite resin and compomer, Int Endod J., 35, (1), 2002, p47 - 55 Journal Article, 2002

Garvey MT, O'Sullivan M, Blake M., Multidisciplinary case-based learning for undergraduate students, Eur J Dent Educ., 4, (4), 2000, p165 - 168 Journal Article, 2000

Leith R, Lowry L, O'Sullivan M, Communication between dentists and laboratory technicians, J Ir Dent Assoc., 46, (1), 2000, p5 - 10 Journal Article, 2000

McDevitt WE, MacCarthy DJ, Dermody J, O'Sullivan M, Shanley DB, Learning a clinical method to identify a mandibular reference position, Eur J Dent Educ., 2, (1), 1988, p33 - 38 Journal Article, 1988

Research Expertise

Description

(1) Special Dental Needs The Restorative Special Needs Clinic is a tertiary referral centre for the treatment of patients with developmental craniofacial and dental anomalies. These are hereditary /developmental disorders that may affect the number, size or quality of teeth. The most common condition is hypodontia, where a person's teeth fail to develop. There is currently no data available for Ireland, but based on other European figures the number of patients in Ireland missing five or more teeth is likely to be 12,000 (0.3% of the total population). The general incidence of hypodontia in European population is 2.3-10.1%. The second most common condition is amelogenesis imperfecta. This term covers a range of conditions where all the enamel is defective. It may present merely as marked pitting of the surface of the tooth to severe cases where the enamel disintegrates upon eruption of the tooth. No data is available on its incidence but studies from other populations put its incidence at 1:4000 to 1:8000 (1% and 2% of the total population). Other dental conditions occur less frequently, such as dentinogenesis imperfecta (the layer under the enamel is poorly formed leading to tooth fracture) and conditions that also affect hair, skin and nails such as ectodermal dysplasia. Research interest in this area includes the clinical management of this population, establishment of a National Database of developmental dental disorders and investigation of the Quality of Life issues associated with these disorders (2) Dental Pulp Biology (with Dr Jeff O'Sullivan, Division of Restorative Dentistry and Periodontology) Currently research is focused on two distinct areas. Our primary focus is understanding the enzymatic regulation of cellular events within dental pulp. These include pain transmission and modulation, the inflammatory response of dental pulp and the mechanisms behind tooth development. Central to our studies of these events is a unique enzyme called semicarbazide-sensitive amine oxidase (SSAO) which is involved in similar events throughout the body and may modulate the response observed. Secondary studies include the role of periodontitis in systemic disease and the utilisation of dental pulp stem cells in neuro-protection. (3) Sleep Apnoea (with Prof Walter McNicholas, Newman Clinical Research Professor, School of Medicine & Medical Science, St. Vincent's University Hospital, Dublin) Obstructive Sleep Apnoea (OSA) is a common sleep-related breathing disorder characterised by repetitive obstructions of the upper airway during sleep. These disorders result from sleep related narrowing of the upper airway, which is thought to be due to varying combinations of anatomical and neuromuscular factors that culminate in an imbalance of forces acting on the airway. This causes airflow limitation (snoring), partial (hypopnea) or complete (apnoea) closure of the upper airway; with consequent adverse effects on sleep quality and gas exchange. Previous studies have examined the relationship between the genioglossus (GG) muscle and OSA. The genioglossus muscles (GG) are the primary protruders of the tongue and play a vital role in maintaining the patency of the upper airway. Genioglossus muscle activity normally decreases in no-OSA individuals, whereas, patients with OSA show an increased level of GG muscle activity, both while awake and asleep, due to the necessity of counteracting the pharyngeal narrowing associated with OSA. Electromyography (EMG) of genioglossus muscles may therefore be an important tool for diagnosing OSA. Through examination of muscle fibre signals from the GG, important information can be extracted, such as conduction velocity, amplitude and frequency of electrical signals. This joint project involves the design and fabrication an oral appliance to measure electromyographic signals from the genioglossus muscle, which is a key factor in the development of sleep apnoea.

Projects

  • Title
    • Database Establishment, Psychological Impact and Quality of Life in a Developmental Dental Anomalies Population
  • Summary
    • There are the principle Aims of the project: (1) Establishment of a National Database for patients with developmental dental anomalies. (2) Quality of life investigations for Adult Hypodontia and Amelogenesis Imperfecta patients. (3) Quality of life investigations for child and adolescent Hypodontia and Amelogenesis Imperfecta.
  • Date From
    • 2005
  • Date To
    • 2011
  • Title
    • Investigating the effect of skeletal pattern in determining articulator settings for prosthodontic rehabilitation: An In-vivo study.
  • Summary
    • Abstract Aims. During extensive prosthodontic treatment the use of an accurately adjusted articulator is recommended to simulate some mandibular movements. This clinical study was undertaken to assess any possible effect of underlying skeletal pattern on programming articulator settings. Materials and Methods. Subjects were recruited (N=73) from a dental school and two regional specialist orthodontic units. Subjects were allocated into groups based on underlying sagittal and vertical skeletal patterns by a group consisting of three orthodontists and three prosthodontists who examined profile photographs. Electronic pantographic recordings were made of each subject with the Cadiax® Compact system to record the sagittal condylar inclination (SCI), progressive mandibular lateral translation (PMLT) and immediate mandibular lateral translation (IMLT). Results. Agreement between assessors for sagittal skeletal pattern classification was excellent (97% for total or good agreement). Agreement between individuals for vertical skeletal pattern was high, but at a lower level than for sagittal relationships (70% for total or good agreement). SCI settings for sagittal II subjects were significantly higher than those for sagittal I (p<0.05) and sagittal III (p<0.001) subjects. No statistical difference could be observed between the SCI values of the sagittal I and sagittal III groups. Subjects with an average vertical skeletal pattern had SCI values lower than those with a reduced vertical skeletal pattern (p=0.058) and significantly lower than subjects with an increased (p<0.01) vertical skeletal pattern. No patterns could be determined for PMLT or IMLT between the study groups. The PMLT measurements for all study groups clustered at the minimum value (5°) and to a lesser extent the maximum (15°). The majority of the sample population had IMLT settings of 0mm, with the remaining values ranging from 0.1 mm to 1mm. Conclusion. During prosthodontic treatment of patients with a noticeable skeletal discrepancy consideration should be given to customising SCI values.
  • Date From
    • 2006
  • Date To
    • 2008
  • Title
    • Disinfection procedures: Their efficacy and effect on dimensional accuracy and surface quality of an irreversible hydrocolloid impression material
  • Summary
    • Abstract Objectives: This study investigated the antibacterial efficacy and effect of 0.55% orthophthalaldehyde (Cidex OPA1) and 0.5% sodium hypochlorite (NaOCl) on the dimensional accuracy and surface quality of gypsum casts retrieved from an irreversible hydrocolloid impression material. Methods: A simulated clinical cast and technique was developed to compare the dimensional accuracy and surface quality changes of the test gypsum casts with controls. Dimensional accuracy measurements were completed between fixed points using a travelling microscope under low angle illumination at a magnification of X3. Surface quality changes of ''smooth'' and ''rough'' areas on the cast were evaluated by means of optical profilometry. The efficacy of the disinfection procedures against Pseudomonas aeruginosa was evaluated by determining the number of colony forming units (cfu) recovered after disinfection of alginate discs inoculated with 1 X 106 cfu for defined intervals. Results: The dimensional accuracy of the gypsum casts was not significantly affected by the disinfection protocols. Neither disinfectant solution nor immersion time had an effect on the surface roughness of the ''smooth'' area on the cast, however, a significant increase in surface roughness was observed with increasing immersion time for the ''rough'' surface. Complete elimination of viable Pseudomonas aeruginosa cells from alginate discs was obtained after 30 and 120 s immersion in Cidex OPA1 and NaOCl, respectively. Conclusions: Immersion of irreversible hydrocolloid impressions in Cidex OPA1 for 30 s was proved to be the most effective disinfection procedure.
  • Date From
    • 2005
  • Date To
    • 2007
  • Title
    • Maxillary anterior tooth dimensions and proportions in an Irish young adult population
  • Summary
    • SUMMARY This study was undertaken in a young Irish population to determine the dimensions and ratios of the six maxillary anterior teeth. One hundred and nine Irish subjects (age 18-25 inclusive) had irreversible hydrocolloid impressions made of their maxillary dentition poured in type V stone. Clinical crown dimensions were measured with a digital calliper. The stone casts were digitally photographed in a standardised manner enabling calculation of various ratios between the maxillary anterior teeth. Sexual dimorphism existed for various tooth dimensions; most notably canine teeth were in the region of 0.8 mm longer and 0.6 mm wider in males. Central and lateral incisors were found to be 0.5 mm wider in males. It is, therefore, recommended that dimensional tooth guidelines should be given for each of the sexes and not on a population basis. With regard to tooth proportion ratios, no significant differences were found between genders or the left and right sides for any of the measurements or ratios measured. The digitally recorded tooth proportions were similar for both sexes, and the Golden Proportion guidelines could only be applied to the lateral incisor ⁄ central incisor widths (0.618). Identified width proportions for the canine ⁄ central incisor were 0.58 and for canine ⁄ lateral incisor 0.89.
  • Date From
    • 2005
  • Date To
    • 2008

Recognition

Memberships

International Association for Dental Research 1993 – Present

American Academy of Fixed Prosthodontics 2001 – Present

Royal College of Surgeons in Ireland 1995 – Present

Royal College of Surgeons in Edinburgh 1994 – Present

External reviewer for the Italian Ministry for Education University and Research. 2008 – 2010

Reviewer for the Journal of the Irish Dental Association 2007 – 2010