Implementation science is emerging as a research approach that can make a difference to people. It aims to learn from the wisdom of practice, generate local knowledge, and then translate that knowledge through research. Implementation science is dependent on effective partnerships between academics and practitioners working in the real world of healthcare. A major component of improvement or implementation science is understanding the complex microsystems that underpin healthcare delivery. Innovation and learning in healthcare should be shared with others. Healthcare staff deserve to have high quality evidence on which to base their efforts to care. This type of research fits with the values and mission of the Trinity Centre for Practice and Healthcare Innovation as it demonstrates an ethical commitment to learning collaboratively in the best interest of service users.