Dr. Michael Wride
Academic Developer, Academic Secretariat
Academic Developer, C.A.P.S.L.
I am currently working as an Academic Developer in the Centre for Academic Practice and eLearning (CAPSL).
My current research interests are in philosophy of science education and creativity in teaching and learning.
I am an adjunct Prof in Zoology at TCD. My research interests have been in eye development.
My BSc is in Physiology and Biochemistry from Southampton University, UK (1990), I have a PhD in Physiology from the University of Alberta, Canada (1996) and I recently (2014) completed my MEd in Higher Education Teaching & Learning here at TCD, through the School of Education.
Publications and Further Research Outputs
Wride M.A., "I found that I've been free all along": knowledge, meaning, creativity and holistic science at Schumacher College. , Holistic Science Journal , 2, (4 ), 2015, p53 - 57
Franses, P. & Wride, M.A., Goethean pedagogy A case in innovative science education and implications for work based learning, Higher Education, Skills and Work-Based Learning, 5, (4), 2015, p339 - 351
Wride M.A., Science play time, Creative Academic, 2, (2), 2015, p19-21-
Wride M.A., 'Re-Creating' Science in Higher Education: Exploring a Creativity Philosophy , MEd, Trinity College Dublin, 2014
Doodnath R, Wride M, Puri P. , The spatio-temporal patterning of Hoxa9 and Hoxa13 in the developing zebrafish enteric nervous system. , Pediatric Surgery International, 28, 2012, p115 - 121
Jarrin M, Mansergh FC, Boulton ME, Gunhaga L, Wride MA., Survivin expression is associated with lens epithelial cell proliferation and fiber cell differentiation. , Molecular Vision, 18, 2012, p2758 - 2769
Wride M.A., Wormstone I.M., Introduction: The Ocular Lens: A Classic Model for Development, Physiology and Disease. , Philosophical Transactions of the Royal Society B, In Press, (366), 2011, p1190 - 1192
Powell KA, Davies JR, Taylor E, Wride MA, Votruba M., Mitochondrial localization and ocular expression of mutant Opa3 in a mouse model of 3-methylglutaconicaciduria type III, Investigative Ophthalmology & Visual Sciences, 52, 2011, p4369 - 4380
Bazou D, Kearney R, Mansergh F, Bourdon C, Farrar J, Wride M, Gene expression analysis of mouse embryonic stem cells following levitation in an ultrasound standing wave trap., Ultrasound in medicine & biology, 37, (2), 2011, p321-30
Wride MA, Lens fibre cell differentiation and organelle loss: many paths lead to clarity., Philosophical Transactions of the Royal Society B, 366, 2011, p1219 - 1233
Wride M.A., Wormstone I.M. (Eds) , The Ocular Lens: A Classic Model for Development, Physiology and Disease, 2011, -
Doodnath R, Dervan A, Wride MA, Puri P, Zebrafish: an exciting model for investigating the spatio-temporal pattern of enteric nervous system development, Pediatric Surgery International, 26, 2010, p1217 - 1221
Kisiswa L, Dervan AG, Albon J, Morgan JE, Wride MA, Retinal Ganglion Cell Death Postponed: Giving Apoptosis a Break?, Ophthalmic Research, 43, 2010, p61 - 78
Kisiswa L., Albon J., Morgan J.E., Wride M.A., Cellular inhibitor of apoptosis (cIAP1) is down-regulated during retinal ganglion cell (RGC) maturation., Experimental Eye Research, 91, 2010, p739 - 747
Goodall N, Kisiswa L, Prashar A, Faulkner S, Tokarczuk P, Singh KD, Erichsen JT, Guggenheim J, Halfter W, Wride MA, PhD, 3-Dimensional Modelling of Chick Embryo Eye Development and Growth Using High Resolution Magnetic Resonance Imaging, Experimental Eye Research, 89, (4), 2009, p511 - 521
Geattrell J.C., Gan P-M., Mansergh F.C., Jarrin, M., Kisiswa L., Williams L., Evans M.J., Boulton M.E., Wride M.A., Apoptosis gene profiling reveals spatio-temporal regulated expression of the p53/Mdm2 pathway during lens development., Experimental Eye Research, 88, 2009, p1137 - 1151
Mansergh F.C., Daly C.S.,.Hurley A.L, Wride M.A.,. Hunter S.M. and Evans M.J. , Gene expression profiles during early differentiation of mouse embryonic stem cells, BMC, Developmental Biology , 9, (1), 2009, p5-
Biophysics and Age Changes of the Crystalline Lens. in, Daniel M. Albert, MD, MS, Joan W. Miller, MD, Dimitri T. Azar, MD and Barbara A. Blodi, MD , Albert and Jakobiec's Principles and Practice of Ophthalmology, 3rd Edition, Elsevier-Saunders, 2008, [Boulton M.E., Rozanowska M., Wride M.A. ]
Davies VJ, Powell KA, White KE, Yip W, Hogan V, Hollins AJ, Davies JR, Piechota M, Brownstein DG, Moat SJ, Nichols PP, Wride MA, Boulton ME, Votruba M., A missense mutation in the murine Opa3 gene models human Costeff syndrome , Brain, 131, 2008, p368 - 380
Bioinformatics, Binder, M.D., Hirokawa, N., Windhorst, U., Hirsch, M.C., The Encyclopedia of Neuroscience, Heidelberg, Germany, Springer, 2008, [Mansergh F.C., Wride M.A.]
Mansergh F.C., Hunter S.M., Geatrell J.C., Jarrin M., Powell K., Evans M.J., Wride M.A., Developmentally regulated expression of hemoglobin subunits in avascular tissues, International Journal of Developmental Biology, 52, 2008, p873 - 886
Wride M.A. , Proteases in the development and diseases of the lens, Expert Review of Ophthalmology , 2, (5), 2007, p833 - 844
Wride M.A., Geattrell J., Guggenheim J.A., Proteases in eye development and disease., Embryo Today (Birth Defects Research part C) , 78, 2006, p90 - 105
Boulton M, Wride M, Can Toxicogenomics be Used to Identify Chemicals that Cause Ocular Injury?, ALTEX, 23 Suppl, 2006, 318 - 320
Mansergh F.C., Wride M.A., Walker V., Adams S., Hunter S.M., Evans M.J. , Gene expression changes during cataract progression in Sparc null mice: differential regulation of mouse globins in the lens. , Molecular Vision, 10, 2004, p490 - 511
Wride M.A., Mansergh F.C., Adams S., Everitt R, Minnema S.E., Evans M.J., Rancourt D.E. , Expression profiling and gene discovery in the mouse lens. , Molecular Vision, 9, 2003, p360 - 396
Neurons, Stem Cells and Potential Therapies in, Sell S , Stem Cell Handbook, Totowa, New Jersey, Humana Press, 2003, pp177 - 190, [Mansergh F.C., Wride M.A., Rancourt D.E. ]
Andrew S.D., Kuiper M.J., Wride M.A, Mansergh F.C., Rancourt D.E., Mulligan L.M. , Structural variation in a novel zinc finger protein and investigation of its role in Hirschsprung disease. , Gene Function & Disease , 3, 2003, p69 - 76
Everitt R., Minnema S.E., Wride M.A., Koster C.S., Hance J.E., Mansergh F.C., Rancourt D.E. , RED: the analysis, management and dissemination of expressed sequence tags. , Bioinformatics, 18, 2002, p1692 - 1693
Wride M.A., Mansergh F.C., Somani J.M., Winkfein R J., Rancourt D.E. , Characterization and in silico mapping of a novel murine zinc finger transcription factor, Gene , 289, (1-2), 2002, p49 - 59
Bain G., Mansergh F.C., Wride M.A., Hance J.E., Isogawa A., Rancourt S.L., Ray W.J., Yoshimura Y., Tsuzuki T., Gottlieb D.I., Rancourt D.E. , ES Cell Neural Differentiation Reveals a Substantial Number of Novel Neural ESTs, Functional & Integrative Genomics , 1, (2), 2000, p127 - 139
Mansergh F.C., Wride M.A., Rancourt D.E., Neural stem cells: implications for understanding nervous system development and disease. , Biochem. Cell Biol, 78, (5), 2000, p613 - 628
Wride M.A., Minireview: apoptosis as seen through a lens, Apoptosis, 5, (3), 2000, p203 - 209
Wride M.A., Parker E., Sanders E.J., Members of the bcl-2 and caspase families regulate nuclear degeneration during chick lens fibre cell differentiation, Developmental Biology, 213, (1), 1999, p142 - 156
Wride M.A., Sanders E.J., Nuclear degeneration in the developing lens and its regulation by TNFalpha, Experimental Eye Research, 66, (3), 1998, p371 - 383
Sanders E.J., Wride M.A., Roles for growth and differentiation factors in avian development, Poultry Science, 76, (1), 1997, p111 - 117
Sanders E.J., Prasad S., Hu N., Wride M.A., Cell death in the gastrulating chick embryo: potential roles for tumour necrosis factor-alpha (TNF-alpha), Cell Death and Differentiation, 4, (3), 1997, p188 - 199
Sanders E.J., Wride M.A., Ultrastructural identification of apoptotic nuclei using the TUNEL technique, The Histochemical Journal, 28(4):275-81, (4), 1996, p275 - 281
Wride M.A., Cellular and molecular features of lens development: a review of recent advances, Differentiation, 61, (2), 1996, p77 - 93
Wride M.A., Sanders E.J., Potential roles for tumour necrosis factor-alpha during embryonic development, Anatomy and Embryology, 191, (1), 1995, p1 - 105
Sanders E.J., Wride M.A., Programmed cell death in development, International Review of Cytology, 163, 1995, p105 - 173
Sanders E.J., Hu N., Wride M.A. , Expression of TGFß1 during early chick embryo development, Anatomical Record, 238, (3), 1994, p397 - 406
Wride M.A., Lapchak P.H., Sanders E.J., Distribution of TNFalpha-like proteins correlates with some regions of programmed cell death in the chick embryo, International Journal of Developmental Biology, 38, (4), 1994, p673 - 682
Wride M.A., Sanders E.J., Expression of tumor necrosis factor-alpha (TNF-alpha) cross-reactive proteins during early chick embryo development. , Developmental Dynamics, 198, (3), 1993, p225 - 239
Grimble R.F., Jackson A.A., Persaud C., Wride M.A., Delers F., Engler R., Cysteine and glycine supplementation modulate the metabolic response to tumor necrosis factor ? in rats fed a low protein diet, Journal of Nutrition, 122, (11), 1992, p2066 - 2073
Kisiswa L., Albon J., Wride M.A., Morgan J.E. , Age-related dendrite pruning in the adult brown Norway (BN) rat retina., Association for Research in Vision and Ophthalmology (ARVO), Miami, Florida, 4050/A443, 2010
Albon J, Giles P.J., Galay-Burgos M., Wride M.A., Boulton M.E., Nowak-Musial M.M. , Microarray analysis of gene expression in the corneal epithelium during development. , Association for Research in Vision and Ophthalmology (ARVO), Miami, Florida, 3752/D933., 2010
Powell K.A., Davies A.J.,Taylor E, Mansergh F., Wride M., Votruba M. , Optic atrophy associated protein Opa3 localises to mitochondria and is expressed in the mouse lens. , Association for Research in Vision and Ophthalmology (ARVO), Miami, Florida, 3752/D933., Florida, 2010
Doodnath, R., Dervan, A., Puri, P., Wride, M.A. , The use of zebrafish to study the spatio-temporal pattern of enteric nervous system development, BSDB and BSCB 2010, p105, Warwick, UK, 2010
Kisiswa L., Albon J., Morgan J.E., Wride M.A. , Age-dependent reduction in the expression of cellular inhibitor of apoptoisis 1 (cIAP1) in the retina: implications for age-related retinal degeneration and glaucoma. , Society for Neuroscience, Chicago, USA, L27 837.19., 2009
Wride M.A., Kisiswa L., Albon J., Morgan J.E., , Apoptosis signalling in the ageing and glaucomatous retina: implications for dendrite remodelling and cell death during neurodegeneration. , Ist ANNUAL MEETING IBILI, Coimbre, Portugal, 2009
Wride M.A., Jones M., Marples M.M., Mitchell F, The light of life: can you believe your eyes?, Lightwave: ready to be illuminated?, Science Gallery, TCD, Feb 5, 2008, Science Gallery, TCD
Geattrell J.C., Gan P-M., Mansergh F.C., Jarrin, M., Kisiswa L., Williams L., Evans M.J., Boulton M.E., Wride M.A. , Apoptosis gene profiling reveals spatio-temporal regulated expression of the p53/Mdm2 pathway during lens development. , 11TH IRISH NETWORK OF DEVELOPMENTAL BIOLOGISTS MEETING , UCD, Dublin, Ireland, November, 2008
Nowak M.M., Wride M.A., Boulton M.E., Albon J., Identification of critical stages in development of chicken corneal epithelium, ARVO Abstract 3376/A230, Association for Research in Vision and Ophthalmology (ARVO), Miami, Florida, 2008
Wride M.A., Mansergh F.C., Hunter S.M., Geatrell J.C., Jarrin M., Powell K.A., Evans M.J.,, New blood for hemoglobin in the lens: roles in stem cell differentiation and fibre cell organelle loss? , Acta Ophthalmalogica , European Association for Vision and Eye Research (EVER) , Portoroz, Slovenia, October 2008, 86, (s243), 2008, pp4244-
Goodall N., Prashar A., Faulkner S., Tokarczuk P., Guggenheim J., Singh K., Wride M.A. , Magnetic resonance imaging of chick ocular development. , 11th Irish Network Of Developmental Biologists Meeting UCD, Dublin, Ireland., 2008
Wride M.A., Mansergh F.C., Geatrell J., Jarrin M., Hunter S., Evans M.J., Roles for haemoglobin outside the haematopoietic system: expression of haemoglobin during ocular lens and embryoid body differentiation, 10TH IRISH NETWORK OF DEVELOPMENTAL BIOLOGISTS (INDB) MEETING , Cork, Ireland, 2007, INDB
Wride M.A., The developing lens: a unique model system, Zoology seminar series, Zoology Department, Trinity College Dublin, 2007
Jarrin M., Boulton M.E., Wride M.A., Spatio-temporal analysis of survivin expression during lens development, ARVO Abstract 2909/B124, Association for Research in Vision and Ophthalmology (ARVO), Miami, Florida, 2007
Nowak M., Wride M.A., Boulton M.E., Albon J., Identification of critical stages in development of the chick corneal epithelium, 1st International Chick Development Meeting, Barcelona, Spain, 2007
Williams L.A., Boulton M.E., Wride M.A., Identification of tumour necrosis factors and expression of TRAIL and TRAF 3 during chick lens development, ARVO Abstract 2909/B124, Association for Research in Vision and Ophthalmology (ARVO), Miami, Florida, 2007
Goodall N., Prashar A., Faulkner S., Tokarczuk P., Guggenheim J., Singh K., Wride M.A., Magnetic resonance imaging of chick ocular development, 1st International Chick Development Meeting, Barcelona, Spain, 2007
Trego M.E., Wride M.A., Dizhoor A.M., Boulton M.E., Expression of the Alpha-Crystallins in the Retinal Pigment Epithelium and Neural Retina in the Human and Mouse, ARVO Abstract 2888/B664, Association for Research in Vision and Ophthalmology (ARVO), Miami, Florida, 2006
Jarrin M., Boulton M.E., Wride M.A. , Spatio-temporal analysis of survivin expression during lens development, 1st Meeting of the International Society of Ocular Cell Biology (ISOCB), , Homerton College, Cambridge, UK, 2006
Evans J.C., Boulton M.E., Wride M.A., Apoptosis Gene Expression Profiling in Mouse Lens Maturation, ARVO Abstract 2548/B476, Association for Research in Vision and Ophthalmology (ARVO), Miami, Florida, 2006
Geatrell (Evans) J.C., Boulton M.E., Wride M.A. , Apoptosis genes in lens differentiation: identification by array analysis, 1st Meeting of The International Society of Ocular Cell Biology (ISOCB), Homerton College, Cambridge, UK, 2006
Wride M.A., Mansergh F.C., Evans M.J., The lens as a model for apoptosis and transcriptional profiling of cataract, 1st Kyoto Prefectural University of Medicine and Cardiff University collaborative conference, Kyoto, Japan, 2005, Kyoto Prefectural University of Medicine
Wride M.A., Transcriptional profiling of the lens in health and disease, XVI INTERNATIONAL CONGRESS OF EYE RESEARCH, Sydney, Australia, 2004, International Society of Eye Research
Wride M.A., Microarray analysis of the ocular lens during maturation and cataract , UNIVERSITY OF TUEBINGEN, Tuebingen, Germany, Max Planck Institute For Developmental Biology , 2004
Wride M.A., Gene expression profiling of the lens during maturation and cataract progression, ROCHE Ltd., Basel, Switzerland, 2004
Assiri A.A. M., Wride M.A., Mansergh F.C., Walker V.E., Young R.D., Evans M.J., Quantock A.J., Corneal stromal ultrastructure in mice with Sparc-null mutations, IOVS Supplement 3822/B283, American Association for Research in Vision and Ophthalmology (ARVO), Miami, Fliorida, 2004
Wride M.A., Geatrell J., Boulton M.E., Evans M.J. , Apoptosis gene expression profiling in mouse lens maturation, INTERNATIONAL CONGRESS OF EYE RESEARCH LENS SATELLITE MEETING, Rotorua, New Zealand, 2004, University of Auckland
DescriptionProfessional development in academic practice Creativity and the curriculum Active learning Philosophy of science education Goethean Science
- Enriching Undergraduate Pedagogical Practices Through Transdisciplinary Design and Collaborative Enquiry
- This project aims to enrich academic practices across the full academic life cycle, from undergraduates to professors, by resurrecting the original meaning of the word University: from medieval latin universitatem, "the whole, aggregate," in late latin "corporation, society," from universus "whole, entire". We propose a participatory action research project aimed at "fostering relationships between students, faculty and alumni, and harnessing this collective expertise for the benefit of students"*, through the development of a module and best practices in Transdisciplinary Design and Collaborative Enquiry that transcends disciplines and contributes towards overcoming fragmentation of knowledge, thereby fostering and supporting creativity, innovation and societal responsibility.
- Funding Agency
- Date From
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- The role of inhibitors of apoptosis (IAPs) during chick retinal ganglion cell (RGC) development
- Characterisation of the spatio-temporal pattern of expression of inhibitors of apoptosis (IAPs) during retinal ganglion cell (RGC) development. Characterisation of the functions of selected IAPs in RGC development using in vitro models of RGC differentiation.
- Funding Agency
- The Government of Saudi Arabia
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- MicroRNAs as biomarkers in human age-related macular degeneration
- Funding Agency
- The Government of Libya, Cultural Commission, London, UK. and IRC
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- The Role of Homeobox Genes in the Development of The Zebrafish Enteric Nervous System: Implications For the Molecular Genetic Basis of Hirschsprung's Disease
- Normal intestinal motility requires coordinated interaction of the enteric nervous system (ENS), smooth muscle cells and interstitial cells of Cajal (ICCs). The ENS is a network of nerve cells and glia that lies within the walls of the gastrointestinal tract. Developmental disorders of the ENS can result in life threatening intestinal obstruction at birth. Hirschsprung's disease (HSCR, aganglionic megacolon) is the commonest, occurring in 1 in 5000 live births. The primary pathology of HSCR is an absence of ganglion cells in the distal gut which leads to intestinal obstruction, resulting in considerable morbidity and mortality. Development of the ENS requires a number of distinct steps that include neural crest cell migration, colonization of the gut, proliferation, and differentiation into neuronal and glial phenotypes. During the past 15 years, there has been an explosion of information about the genes that control the development of the ENS. The Homeobox (Hox) genes are extremely important in development being involved in patterning the early embryo. In Drosophila, Hox genes have been shown by both molecular and genetic analyses to regulate major events in patterning and specification during development. Here we will use zebrafish as a model system to investigate the role of homeobox genes in ENS development.
- Funding Agency
- The Children's Research Centre, Our Lady's Children's Hospital Crumlin, Dublin
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Awards and Honours
The Children's Research Centre, Our Lady's Children's Hospital Crumlin, Dublin (with Prof. Prem Puri, Crumlin Hospital). The Role of Homeobox Genes in the Development of The Zebrafish Enteric Nervous System: Implications For the Molecular Genetic Basis of Hirschsprung's Disease.
The Wellcome Trust Biomedical Summer Vacation Scholarship. Gene Expression Analysis following exposure of Stem Cells to Ultrasound in a Standing Wave Trap.
Ireland-Newfoundland Partnership: Academic Bursary
National Eye Research Centre (NERC) PhD Studentship (Wride M.A., Morgan J.E. and Albon J; Cardiff). The role of caspases and inhibitors of cell death (IAPs) in retinal ganglion cell (RGC) death and dendritic remodelling.
BBSRC Research Grant (Morgan J.E., Drexler W, Votruba, M, Wride M.A.; Cardiff): In vitro detection of neuronal programmed cell death by ultrahigh resolution optic coherence tomography
The Royal Society. "Change of direction" Project Grant application for "seed corn" funding for new projects with promise (Wride M.A.). The role of inhibitors of apoptosis (IAPs) during chick retinal ganglion cell (RGC) development
Medical Research Council, Research Grant (Votruba M, Wride M.A. and Boulton M.E.; Cardiff): OPA3: a novel gene and mechanisms in cataractogenesis.
COLIPA A.I.S.B.L. (also known as, the European Cosmetic Toiletry & Perfumery Association) (Boulton M.E., Wride M.A. and Albon J.; Cardiff): The development of gene expression fingerprints to identify toxic damage to the cornea.
The Wellcome Trust Summer Vacation Scholarship (Wride M.A. and Gan P.M.). Spatio-temporal expression analysis of the apoptosis regulator Mdm2 in lens development.
National Eye Research Centre (NERC), PhD Studentship (Albon J., Wride M.A. and Boulton M.E.; Cardiff): Identification of candidate genes critical to epithelial cell patterning and differentiation during corneal development
The Royal Society, Conference Grant for attending International Congress of Eye Research (ICER) Sydney, Australia and Lens satellite meeting, A Focus on the Lens: Integrating Structure, Function, Differentiation and Cataract Rotorua, New Zealand (Wride M.A.)
BBSRC, PhD Studentship (Wride M.A. and Boulton M.E.; Cardiff): Transcriptional profiling and functional analysis of cell cycle regulators during lens differentiation
National Eye Research Centre (NERC), Research Grant (Wride M.A. and Evans M.J.; Cardiff): Examination of the expression and function of regulators of apoptosis in lens differentiation
The Royal Society, UK, Research Grant (Wride M.A.): Apoptosis genes in the lens
Alberta Heritage Foundation for Medical Research Post-Doctoral Fellowship
Alberta Cancer Board Post-Doctoral Fellowship
Natural Sciences and Engineering Research Council of Canada Post-Doctoral Fellowship
Awarded Membership of U.K. Institute of Biology (MIBiol), becoming a Chartered Biologist (CBiol).
Alberta Heritage Foundation for Medical Research PhD Studentship
Andrew Stewart Memorial Graduate Prize, University of Alberta
University of Alberta Ph.D. Scholarship
Wellcome Foundation Vacation Research Scholarship. Department of Nutrition, University of Southampton
Higher Education Academy, U.K.