Fergal O'Brien
Adjunct Associate Professor, Trinity Centre for Bioengineering
Adjunct Associate Professor, Mechanical & Manuf. Eng

Biography

Prof. Fergal O'Brien is a graduate in mechanical engineering from Trinity College, Dublin. He subsequently carried out research for his PhD in the area of bone biomechanics between RCSI and TCD (awarded 2001). Following his PhD, he was a Fulbright Scholar and carried out research in orthopaedic tissue engineering at Massachusetts Institute of Technology in collaboration with in Harvard Medical School. In May, 2003 he left the US to take up a position as Lecturer in Anatomy in RCSI. He has subsequently developed one of the largest tissue engineering/regenerative medicine groups in Ireland and has been involved in the acquisition of over EUR12 million in grant funding, has published over 100 articles in peer-reviewed international journals, filed 6 patents and graduated 16 PhD students since 2003.

He has been awarded a number of scientific honours including a Fulbright Scholarship (2001), New Investigator Recognition Award by the Orthopaedic Research Society (2002), Science Foundation Ireland, President of Ireland Young Researcher Award (2004), Engineers Ireland Chartered Engineer of the Year (2005) and in 2009, a European Research Council (ERC) Investigator Award (Eur 2 million). He is a Chartered Engineer and Fellow of the Institution of Engineers of Ireland (Engineers Ireland). He has served as a reviewer for over 50 scientific journals and a grant reviewer for agencies in Europe, Australia, Canada and USA. He is currently Treasurer of the Biomedical Division of Engineers Ireland, Committee Member of the Bioengineering Section of the Royal Academy of Medicine in Ireland, Editorial Consultant for the Journal of Biomechanics and Subject Editor (Tissue Engineering) for the Journal of the Mechanical Behavior of Biomedical Materials.

For more information and current news on the Bone & Tissue Engineering Research Group in RCSI: www.rcsi.ie/boneresearch.

Office Contact Details: Email: fjobrien@rcsi.ie. Tel. 01-4022149, Fax. 01-4022355

Publications and Further Research Outputs

Peer-Reviewed Publications

Amos Matsiko, Emmet M. Thompson, Cai Lloyd-Griffith, Gráinne M. Cunniffe, Tatiana Vinardell, John P. Gleeson, Daniel J. Kelly, Fergal J. O'Brien,, An endochondral ossification approach to early-stage bone repair: Use of tissue-engineered hypertrophic cartilage constructs as primordial templates for weight-bearing bone repair, Journal of Tissue Engineering & Regenerative Medicine, 2018, p1- Journal Article, 2018 TARA - Full Text DOI

O'Neill HS, Herron CC, Hastings CL, Deckers R, Lopez Noriega A, Kelly HM, Hennink WE, McDonnell CO, O'Brien FJ, Ruiz-Hernández E, Duffy GP, A stimuli responsive liposome loaded hydrogel provides flexible on-demand release of therapeutic agents, Acta Biomaterialia, 48, 2017, p110 - 119 Journal Article, 2017

Ryan, A.J. and Lackington, W.A. and Hibbitts, A.J. and Matheson, A. and Alekseeva, T. and Stejskalova, A. and Roche, P. and O'Brien, F.J., A Physicochemically Optimized and Neuroconductive Biphasic Nerve Guidance Conduit for Peripheral Nerve Repair, Advanced Healthcare Materials, 6, (24), 2017 Journal Article, 2017 DOI

Cunniffe G.M, Díaz-Payno P.J, Ramey J.S, Mahon O.R, Dunne A, Thompson E.M, O†Brien F.J, Kelly D.J, Growth plate extracellular matrix-derived scaffolds for large bone defect healing, European Cells and Materials, 33, 2017, p130 - 142 Journal Article, 2017 URL DOI

Evans, J.C. and Malhotra, M. and Fitzgerald, K.A. and Guo, J. and Cronin, M.F. and Curtin, C.M. and O'Brien, F.J. and Darcy, R. and O'Driscoll, C.M., Formulation and Evaluation of Anisamide-Targeted Amphiphilic Cyclodextrin Nanoparticles to Promote Therapeutic Gene Silencing in a 3D Prostate Cancer Bone Metastases Model, Molecular Pharmaceutics, 14, (1), 2017, p42-52 Journal Article, 2017 DOI

Stack, J.D. and Levingstone, T.J. and Lalor, W. and Sanders, R. and Kearney, C. and O'Brien, F.J. and David, F., Repair of large osteochondritis dissecans lesions using a novel multilayered tissue engineered construct in an equine athlete, Journal of Tissue Engineering and Regenerative Medicine, 11, (10), 2017, p2785-2795 Journal Article, 2017 DOI

Roche, P. and Alekseeva, T. and Widaa, A. and Ryan, A. and Matsiko, A. and Walsh, M. and Duffy, G.P. and O'Brien, F.J., Olfactory Derived Stem Cells Delivered in a Biphasic Conduit Promote Peripheral Nerve Repair In Vivo, Stem Cells Translational Medicine, 6, (10), 2017, p1894-1904 Journal Article, 2017 DOI

Lebre, F. and Sridharan, R. and Sawkins, M.J. and Kelly, D.J. and O'Brien, F.J. and Lavelle, E.C., The shape and size of hydroxyapatite particles dictate inflammatory responses following implantation, Scientific Reports, 7, (1), 2017, p2922 - Journal Article, 2017 TARA - Full Text DOI

Curtin, C.M. and Castaño, I.M. and O'Brien, F.J., Scaffold-Based microRNA Therapies in Regenerative Medicine and Cancer, Advanced Healthcare Materials, 2017 Journal Article, 2017 DOI

Henrique V. Almeida, Anna D. Dikina, Kevin J. Mulhall, Fergal J. O"Brien, Eben Alsberg, Daniel J. Kelly, Porous Scaffolds Derived from Devitalized Tissue Engineered Cartilaginous Matrix Support Chondrogenesis of Adult Stem Cells, ACS Biomaterials Science & Engineering, 3, (6), 2017, p1075-1082 Journal Article, 2017 TARA - Full Text DOI

O'Leary, C. and O'Brien, F.J. and Cryan, S.-A., Retinoic Acid-Loaded Collagen-Hyaluronate Scaffolds: A Bioactive Material for Respiratory Tissue Regeneration, ACS Biomaterials Science and Engineering, 3, (7), 2017, p1381-1393 Journal Article, 2017 DOI

Gilroy, D.A. and Hobbs, C. and Nicolosi, V. and Buckley, C.T. and O'Brien, F.J. and Kearney, C.J., Development of magnetically active scaffolds as intrinsically-deformable bioreactors, MRS Communications, 7, (3), 2017, p367-374 Journal Article, 2017 DOI

Barreto, S. and Gonzalez-Vazquez, A. and Cameron, A.R. and Cavanagh, B. and Murray, D.J. and O'Brien, F.J., Identification of the mechanisms by which age alters the mechanosensitivity of mesenchymal stromal cells on substrates of differing stiffness: Implications for osteogenesis and angiogenesis, Acta Biomaterialia, 53, 2017, p59-69 Journal Article, 2017 DOI

Barreto, S. and González-Vázquez, A. and Cameron, R.A. and O'Brien, F.J. and Murray, D.J., Identification of stiffness-induced signalling mechanisms in cells from patent and fused sutures associated with craniosynostosis, Scientific Reports, 7, (1), 2017 Journal Article, 2017 DOI

Quinlan, E. and López-Noriega, A. and Thompson, E.M. and Hibbitts, A. and Cryan, S.A. and O'Brien, F.J., Controlled release of vascular endothelial growth factor from spray-dried alginate microparticles in collagenâ€"hydroxyapatite scaffolds for promoting vascularization and bone repair, Journal of Tissue Engineering and Regenerative Medicine, 11, (4), 2017, p1097-1109 Journal Article, 2017 DOI

Brougham, C.M. and Levingstone, T.J. and Shen, N. and Cooney, G.M. and Jockenhoevel, S. and Flanagan, T.C. and O'Brien, F.J., Freeze-Drying as a Novel Biofabrication Method for Achieving a Controlled Microarchitecture within Large, Complex Natural Biomaterial Scaffolds, Advanced Healthcare Materials, 6, (21), 2017 Journal Article, 2017 DOI

Ryan, A.J. and O'Neill, H.S. and Duffy, G.P. and O'Brien, F.J., Advances in polymeric islet cell encapsulation technologies to limit the foreign body response and provide immunoisolation, Current Opinion in Pharmacology, 36, 2017, p66-71 Journal Article, 2017 DOI

Walsh, D.P. and Heise, A. and O'Brien, F.J. and Cryan, S.-A., An efficient, non-viral dendritic vector for gene delivery in tissue engineering, Gene Therapy, 24, (11), 2017, p681-691 Journal Article, 2017 DOI

O'Neill, H.S. and O'Sullivan, J. and Porteous, N. and Ruiz-Hernandez, E. and Kelly, H.M. and O'Brien, F.J. and Duffy, G.P., A collagen cardiac patch incorporating alginate microparticles permits the controlled release of hepatocyte growth factor and insulin-like growth factor-1 to enhance cardiac stem cell migration and proliferation, Journal of Tissue Engineering and Regenerative Medicine, 2017 Journal Article, 2017 DOI

Gonzalez-Fernandez, T., Sathy, B.N., Hobbs, C., Cunniffe, G.M., McCarthy, H.O., Dunne, N.J., Nicolosi, V., O'Brien, F.J., Kelly, D.J., Mesenchymal stem cell fate following non-viral gene transfection strongly depends on the choice of delivery vector, Acta Biomaterialia, 55, 2017, p226-238 Journal Article, 2017 TARA - Full Text DOI

Almeida, H.V. and Sathy, B.N. and Dudurych, I. and Buckley, C.T. and O'Brien, F.J. and Kelly, D.J., Anisotropic Shape-Memory Alginate Scaffolds Functionalized with Either Type I or Type II Collagen for Cartilage Tissue Engineering, Tissue engineering. Part A, 23, (1-2), 2017, p55-68 Journal Article, 2017 TARA - Full Text DOI

Laiva, A.L. and O'Brien, F.J. and Keogh, M.B., Innovations in gene and growth factor delivery systems for diabetic wound healing, Journal of Tissue Engineering and Regenerative Medicine, 2017 Journal Article, 2017 DOI

Davis, N.F. and Cunnane, E.M. and O'Brien, F.J. and Mulvihill, J.J. and Walsh, M.T., Tissue engineered extracellular matrices (ECMs) in urology: Evolution and future directions, Surgeon, 2017 Journal Article, 2017 DOI

Raftery, R.M. and Mencía Castaño, I. and Chen, G. and Cavanagh, B. and Quinn, B. and Curtin, C.M. and Cryan, S.A. and O'Brien, F.J., Translating the role of osteogenic-angiogenic coupling in bone formation: Highly efficient chitosan-pDNA activated scaffolds can accelerate bone regeneration in critical-sized bone defects, Biomaterials, 149, 2017, p116-127 Journal Article, 2017 DOI

Do Amaral, R.J.F.C. and Almeida, H.V. and Kelly, D.J. and O'Brien, F.J. and Kearney, C.J., Infrapatellar Fat Pad Stem Cells: From Developmental Biology to Cell Therapy, Stem Cells International, 2017, 2017, p6843727- Journal Article, 2017 DOI TARA - Full Text

Lackington, W.A. and Ryan, A.J. and O'Brien, F.J., Advances in Nerve Guidance Conduit-Based Therapeutics for Peripheral Nerve Repair, ACS Biomaterials Science and Engineering, 3, (7), 2017, p1221-1235 Journal Article, 2017 DOI

Almeida, H.V., Mulhall, K.J., O'Brien, F.J., Kelly, D.J., Stem cells display a donor dependent response to escalating levels of growth factor release from extracellular matrix-derived scaffolds, Journal of Tissue Engineering and Regenerative Medicine, 2016, p1-9- Journal Article, 2016 TARA - Full Text DOI

Levingstone, T.J. and Ramesh, A. and Brady, R.T. and Brama, P.A.J. and Kearney, C. and Gleeson, J.P. and O'Brien, F.J., Cell-free multi-layered collagen-based scaffolds demonstrate layer specific regeneration of functional osteochondral tissue in caprine joints, Biomaterials, 87, 2016, p69-81 Journal Article, 2016 DOI

Murphy, C.M. and Duffy, G.P. and Schindeler, A. and O'Brien, F.J., Effect of collagen-glycosaminoglycan scaffold pore size on matrix mineralization and cellular behavior in different cell types, Journal of Biomedical Materials Research - Part A, 104, (1), 2016, p291-304 Journal Article, 2016 DOI

O'Leary, C. and Cavanagh, B. and Unger, R.E. and Kirkpatrick, C.J. and O'Dea, S. and O'Brien, F.J. and Cryan, S.-A., The development of a tissue-engineered tracheobronchial epithelial model using a bilayered collagen-hyaluronate scaffold, Biomaterials, 85, 2016, p111-127 Journal Article, 2016 DOI

Raftery, R.M. and Walsh, D.P. and Castaño, I.M. and Heise, A. and Duffy, G.P. and Cryan, S.-A. and O'Brien, F.J., Delivering Nucleic-Acid Based Nanomedicines on Biomaterial Scaffolds for Orthopedic Tissue Repair: Challenges, Progress and Future Perspectives, Advanced Materials, 2016, p5447-5469 Journal Article, 2016 DOI

Almeida, H.V., Eswaramoorthy, R., Cunniffe, G.M., Buckley, C.T., O'Brien, F.J., Kelly, D.J., Fibrin hydrogels functionalized with cartilage extracellular matrix and incorporating freshly isolated stromal cells as an injectable for cartilage regeneration, Acta Biomaterialia, 36, 2016, p55-62 Journal Article, 2016 DOI TARA - Full Text

Thompson, E.M., Matsiko, A., Kelly, D.J., Gleeson, J.P., O'Brien, F.J., An Endochondral Ossification-Based Approach to Bone Repair: Chondrogenically Primed Mesenchymal Stem Cell-Laden Scaffolds Support Greater Repair of Critical-Sized Cranial Defects Than Osteogenically Stimulated Constructs in Vivo, Tissue Engineering - Part A, 22, (5-6), 2016, p556-567 Journal Article, 2016 DOI

Raftery, R.M. and Woods, B. and Marques, A.L.P. and Moreira-Silva, J. and Silva, T.H. and Cryan, S.-A. and Reis, R.L. and O'Brien, F.J., Multifunctional biomaterials from the sea: Assessing the effects of chitosan incorporation into collagen scaffolds on mechanical and biological functionality, Acta Biomaterialia, 43, 2016, p160-169 Journal Article, 2016 DOI

Leszczynska, A. and O'Doherty, A. and Farrell, E. and Pindjakova, J. and O'Brien, F.J. and O'Brien, T. and Barry, F. and Murphy, M., Differentiation of Vascular Stem Cells Contributes to Ectopic Calcification of Atherosclerotic Plaque, Stem Cells, 34, (4), 2016, p913-923 Journal Article, 2016 DOI

O'Neill, H.S., Gallagher, L.B., O'Sullivan, J., Whyte, W., Curley, C., Dolan, E., Hameed, A., O'Dwyer, J., Payne, C., O'Reilly, D., Ruiz-Hernandez, E., Roche, E.T., O'Brien, F.J., Cryan, S.A., Kelly, H., Murphy, B., Duffy, G.P., Biomaterial-Enhanced Cell and Drug Delivery: Lessons Learned in the Cardiac Field and Future Perspectives, Advanced Materials, 2016, p5648-5661- Journal Article, 2016 DOI

Gonzalez-Fernandez, T., Tierney, E.G., Cunniffe, G.M., O'Brien, F.J., Kelly, D.J., Gene Delivery of TGF-ß3 and BMP2 in an MSC-Laden Alginate Hydrogel for Articular Cartilage and Endochondral Bone Tissue Engineering, Tissue Engineering - Part A, 22, (9-10), 2016, p776-787 Journal Article, 2016 TARA - Full Text DOI

Ryan, A.J. and Brougham, C.M. and Garciarena, C.D. and Kerrigan, S.W. and O'Brien, F.J., Towards 3D in vitro models for the study of cardiovascular tissues and disease, Drug Discovery Today, 21, (9), 2016, p1437-1445 Journal Article, 2016 DOI

Menciá Castanõ, I. and Curtin, C.M. and Duffy, G.P. and O'Brien, F.J., Next generation bone tissue engineering: Non-viral miR-133a inhibition using collagen-nanohydroxyapatite scaffolds rapidly enhances osteogenesis, Scientific Reports, 6, (27941), 2016 Journal Article, 2016 DOI

Levingstone, T.J. and Thompson, E. and Matsiko, A. and Schepens, A. and Gleeson, J.P. and O'brien, F.J., Multi-layered collagen-based scaffolds for osteochondral defect repair in rabbits, Acta Biomaterialia, 32, 2016, p149-160 Journal Article, 2016 DOI

Kearney, C.J. and Lucas, C.R. and O'Brien, F.J. and Castro, C.E., DNA Origami: Folded DNA-Nanodevices That Can Direct and Interpret Cell Behavior, Advanced Materials, 2016, p5509-5524 Journal Article, 2016 DOI

Cunniffe, G.M. and Curtin, C.M. and Thompson, E.M. and Dickson, G.R. and O'Brien, F.J., Content-Dependent Osteogenic Response of Nanohydroxyapatite: An in Vitro and in Vivo Assessment within Collagen-Based Scaffolds, ACS Applied Materials and Interfaces, 8, (36), 2016, p23477-23488 Journal Article, 2016 DOI

Lloyd-Griffith, C. and Duffy, G.P. and O'Brien, F.J., Investigating the effect of hypoxic culture on the endothelial differentiation of human amniotic fluid-derived stem cells, Journal of Anatomy, 227, (6), 2015, p767-780 Journal Article, 2015 DOI

O'Leary, C. and Gilbert, J.L. and O'Dea, S. and O'Brien, F.J. and Cryan, S.-A., Respiratory Tissue Engineering: Current Status and Opportunities for the Future, Tissue Engineering - Part B: Reviews, 21, (4), 2015, p323-344 Journal Article, 2015 DOI

Fitzgerald, K.A. and Malhotra, M. and Curtin, C.M. and O'Brien, F.J. and O'Driscoll, C.M., Life in 3D is never flat: 3D models to optimise drug delivery, Journal of Controlled Release, 215, 2015, p39-54 Journal Article, 2015 DOI

Brennan, O. and Stenson, B. and Widaa, A. and O'Gorman, D.M. and O'Brien, F.J., Incorporation of the natural marine multi-mineral dietary supplement Aquamin enhances osteogenesis and improves the mechanical properties of a collagen-based bone graft substitute, Journal of the Mechanical Behavior of Biomedical Materials, 47, 2015, p114-123 Journal Article, 2015 DOI

Cunniffe, G.M., Vinardell, T., Murphy, J.M., (...), O'Brien, F.J., Kelly, D.J., Porous decellularized tissue engineered hypertrophic cartilage as a scaffold for large bone defect healing, Acta Biomaterialia, 23, 2015, p82-90 Journal Article, 2015 TARA - Full Text DOI

Ryan, A.J. and O'Brien, F.J., Insoluble elastin reduces collagen scaffold stiffness, improves viscoelastic properties, and induces a contractile phenotype in smooth muscle cells, Biomaterials, 73, 2015, p296-307 Journal Article, 2015 DOI

Thompson EM, Matsiko A, Farrell E, Kelly DJ, O'Brien FJ, Recapitulating endochondral ossification: a promising route to in vivo bone regeneration., Journal of tissue engineering and regenerative medicine, 9, (8), 2015, p889-902 Journal Article, 2015 DOI

Fitzgerald, K.A. and Guo, J. and Tierney, E.G. and Curtin, C.M. and Malhotra, M. and Darcy, R. and O'Brien, F.J. and O'Driscoll, C.M., The use of collagen-based scaffolds to simulate prostate cancer bone metastases with potential for evaluating delivery of nanoparticulate gene therapeutics, Biomaterials, 66, 2015, p53-66 Journal Article, 2015 DOI

Almeida H.V, Cunniffe G.M, Vinardell T, Buckley C.T, O'Brien F.J, Kelly D.J, Coupling Freshly Isolated CD44<sup>+</sup> Infrapatellar Fat Pad-Derived Stromal Cells with a TGF-β3 Eluting Cartilage ECM-Derived Scaffold as a Single-Stage Strategy for Promoting Chondrogenesis, Advanced Healthcare Materials, 4, (7), 2015, p1043 - 1053 Journal Article, 2015 DOI URL

Cunniffe G.M, Vinardell T, Thompson E.M, Daly A.C, Matsiko A, O'Brien F.J, Kelly D.J, Chondrogenically primed mesenchymal stem cell-seeded alginate hydrogels promote early bone formation in critically-sized defects, European Polymer Journal, 72, 2015, p464 - 472 Journal Article, 2015 DOI URL

Lauren Mulcahy, C Curtin, R McCoy, David Taylor, T Clive Lee and Garry Duffy, The effect of bisphosphonate treatment on the biochemical and cellular events during bone remodelling in response to microinjury stimulation, European Cells and Materials, 30, 2015, p271 - 281 Journal Article, 2015 TARA - Full Text

Quinlan, E. and Partap, S. and Azevedo, M.M. and Jell, G. and Stevens, M.M. and O'Brien, F.J., Hypoxia-mimicking bioactive glass/collagen glycosaminoglycan composite scaffolds to enhance angiogenesis and bone repair, Biomaterials, 52, (1), 2015, p358-366 Journal Article, 2015 DOI

Brougham, C.M. and Levingstone, T.J. and Jockenhoevel, S. and Flanagan, T.C. and O'Brien, F.J., Incorporation of fibrin into a collagen-glycosaminoglycan matrix results in a scaffold with improved mechanical properties and enhanced capacity to resist cell-mediated contraction, Acta Biomaterialia, 26, 2015, p205-214 Journal Article, 2015 DOI

Quinlan, E. and Thompson, E.M. and Matsiko, A. and O'Brien, F.J. and López-Noriega, A., Functionalization of a Collagen-Hydroxyapatite Scaffold with Osteostatin to Facilitate Enhanced Bone Regeneration, Advanced Healthcare Materials, 4, (17), 2015, p2649-2656 Journal Article, 2015 DOI

Castaño, I.M. and Curtin, C.M. and Shaw, G. and Mary Murphy, J. and Duffy, G.P. and O'Brien, F.J., A novel collagen-nanohydroxyapatite microRNA-activated scaffold for tissue engineering applications capable of efficient delivery of both miR-mimics and antagomiRs to human mesenchymal stem cells, Journal of Controlled Release, 200, 2015, p42-51 Journal Article, 2015 DOI

López-Noriega, A. and Quinlan, E. and Celikkin, N. and O'Brien, F.J., Incorporation of polymeric microparticles into collagen-hydroxyapatite scaffolds for the delivery of a pro-osteogenic peptide for bone tissue engineering, APL Materials, 3, (1), 2015 Journal Article, 2015 DOI

Brady RT, O'Brien FJ, Hoey DA, Mechanically stimulated bone cells secrete paracrine factors that regulate osteoprogenitor recruitment, proliferation, and differentiation., Biochemical and biophysical research communications, 459, (1), 2015, p118 - 123 Journal Article, 2015 TARA - Full Text

Sridharan, R., Cameron, A.R., Kelly, D.J., Kearney, C.J., O'Brien, F.J., Biomaterial based modulation of macrophage polarization: A review and suggested design principles, Materials Today, 18, (6), 2015, 313-325 Journal Article, 2015 TARA - Full Text DOI

Quinlan, E. and López-Noriega, A. and Thompson, E. and Kelly, H.M. and Cryan, S.A. and O'Brien, F.J., Development of collagen-hydroxyapatite scaffolds incorporating PLGA and alginate microparticles for the controlled delivery of rhBMP-2 for bone tissue engineering, Journal of Controlled Release, 198, 2015, p71-79 Journal Article, 2015 DOI

Lloyd-Griffith, C. and McFadden, T.M. and Duffy, G.P. and Unger, R.E. and Kirkpatrick, C.J. and O'Brien, F.J., The pre-vascularisation of a collagen-chondroitin sulphate scaffold using human amniotic fluid-derived stem cells to enhance and stabilise endothelial cell-mediated vessel formation, Acta Biomaterialia, 26, 2015, p263-273 Journal Article, 2015 DOI

Ryan, A.J. and Gleeson, J.P. and Matsiko, A. and Thompson, E.M. and O'Brien, F.J., Effect of different hydroxyapatite incorporation methods on the structural and biological properties of porous collagen scaffolds for bone repair, Journal of Anatomy, 227, (6), 2015, p732-745 Journal Article, 2015 DOI

Raftery, R.M. and Tierney, E.G. and Curtin, C.M. and Cryan, S.-A. and O'Brien, F.J., Development of a gene-activated scaffold platform for tissue engineering applications using chitosan-pDNA nanoparticles on collagen-based scaffolds, Journal of Controlled Release, 210, (7670), 2015, p84-94 Journal Article, 2015 DOI

Quinlan, E. and Thompson, E.M. and Matsiko, A. and O'Brien, F.J. and López-Noriega, A., Long-term controlled delivery of rhBMP-2 from collagen-hydroxyapatite scaffolds for superior bone tissue regeneration, Journal of Controlled Release, 207, 2015, p112-119 Journal Article, 2015 DOI

Leavy, A., Conway, P., O'Brien M., Seery, A., Smyth, E., Editorial, Irish Educational Studies, 34, (2), 2015, p103-105 Journal Article, 2015

O'Brien, F.J. and Duffy, G.P., Form and function in regenerative medicine: Introduction, Journal of Anatomy, 227, (6), 2015, p705-706 Journal Article, 2015 DOI

Matsiko, A. and Gleeson, J.P. and O'Brien, F.J., Scaffold mean pore size influences mesenchymal stem cell chondrogenic differentiation and matrix deposition, Tissue Engineering - Part A, 21, (3-4), 2015, p486-497 Journal Article, 2015 DOI

Claro T, Kavanagh N, Foster T.J, O'Brien F.J, Kerrigan S.W, Staphylococcus epidermidis serine-aspartate repeat protein G (SdrG) binds to osteoblast integrin alpha V beta 3, Microbes and Infection, 17, (6), 2015, p395 - 401 Journal Article, 2015 DOI URL

David, F. and Levingstone, T.J. and Schneeweiss, W. and de Swarte, M. and Jahns, H. and Gleeson, J.P. and O'Brien, F.J., Enhanced bone healing using collagen-hydroxyapatite scaffold implantation in the treatment of a large multiloculated mandibular aneurysmal bone cyst in a thoroughbred filly, Journal of Tissue Engineering and Regenerative Medicine, 9, (10), 2015, p1193-1199 Journal Article, 2015 DOI

Curtin, C.M. and Tierney, E.G. and Mcsorley, K. and Cryan, S.-A. and Duffy, G.P. and O'Brien, F.J., Combinatorial gene therapy accelerates bone regeneration: Non-viral dual delivery of VEGF and BMP2 in a collagen-nanohydroxyapatite scaffold, Advanced Healthcare Materials, 4, (2), 2015, p223-227 Journal Article, 2015 DOI

Matsiko, A. and Levingstone, T.J. and Gleeson, J.P. and O'Brien, F.J., Incorporation of TGF-Beta 3 within Collagen-Hyaluronic Acid Scaffolds Improves their Chondrogenic Potential, Advanced Healthcare Materials, 4, (8), 2015, p1175-1179 Journal Article, 2015 DOI

Joyce, C.W. and Whately, K.E. and Chan, J.C. and Murphy, M. and O'Brien, F.J. and Carroll, S.M., Flexor tendon repair: A comparative study between a knotless barbed suture repair and a traditional four-strand monofilament suture repair, Journal of Hand Surgery: European Volume, 39, (1), 2014, p40-45 Journal Article, 2014 DOI

Levingstone, Tanya J. Matsiko, Amos Dickson, Glenn R. O'Brien, Fergal J. Gleeson, John P., A biomimetic multi-layered collagen-based scaffold for osteochondral repair, Acta Biomaterialia, 2014 Journal Article, 2014 TARA - Full Text

Lyons, F.G. and Gleeson, J.P. and Partap, S. and Coghlan, K. and O'Brien, F.J., Novel microhydroxyapatite particles in a collagen scaffold: A bioactive bone void filler?, Clinical Orthopaedics and Related Research, 472, (4), 2014, p1318-1328 Journal Article, 2014 DOI

Almeida HV, Liu Y, Cunniffe GM, Mulhall KJ, Matsiko A, Buckley CT, O'Brien FJ, Kelly DJ, Controlled release of transforming growth factor-ß3 from cartilage-extra-cellular-matrix-derived scaffolds to promote chondrogenesis of human-joint-tissue-derived stem cells., Acta biomaterialia, 10, (10), 2014, p4400-9 Journal Article, 2014 DOI TARA - Full Text

Murphy, Ciara M. Schindeler, Aaron Gleeson, John P. Yu, Nicole Y. C. Cantrill, Laurence C. Mikulec, Kathy Peacock, Lauren O'Brien, Fergal J. Little, David G., A collagen-hydroxyapatite scaffold allows for binding and co-delivery of recombinant bone morphogenetic proteins and bisphosphonates, Acta Biomaterialia, 2014 Journal Article, 2014 TARA - Full Text

Brennan, M.A. and Gleeson, J.P. and O'Brien, F.J. and McNamara, L.M., Effects of ageing, prolonged estrogen deficiency and zoledronate on bone tissue mineral distribution, Journal of the Mechanical Behavior of Biomedical Materials, 29, 2014, p161-170 Journal Article, 2014 DOI

Widaa, A. and Brennan, O. and O'Gorman, D.M. and O'Brien, F.J., The osteogenic potential of the marine-derived multi-mineral formula aquamin is enhanced by the presence of vitamin D, Phytotherapy Research, 28, (5), 2014, p678-684 Journal Article, 2014 DOI

López-Noriega, A.; Hastings, C.L.; Ozbakir, B.; O'Donnell, K.E.; O'Brien, F.J.; Storm, G.; Hennink, W.E.; Duffy, G.P.; Ruiz-Hernández, E.* , Hyperthermia-induced drug delivery from thermosensitive liposomes encapsulated in an injectable hydrogel for intratumoral chemotherapy, Advanced Healthcare Materials , 3, 2014, p854 - 859 Journal Article, 2014

Sheridan, W.S., Ryan, A.J., Duffy, G.P., O"Brien, F.J., Murphy, B.P., An experimental investigation of the effect of mechanical and biochemical stimuli on cell migration within a decellularized vascular construct, Annals of Biomedical Engineering, 42, (10), 2014, p2029-2038 Journal Article, 2014

López-Noriega, A.; Ruiz-Hernández, E.*; Quinlan, E.; Storm, G.; Hennink, W.E.; O'Brien, F.J., Thermally triggered release of a pro-osteogenic peptide from a functionalized collagen-based scaffold using thermosensitive liposomes, Journal of Controlled Release , 187, 2014, p158 - 166 Journal Article, 2014

Brennan, M.Ã . and Haugh, M.G. and O'Brien, F.J. and McNamara, L.M., Estrogen withdrawal from osteoblasts and osteocytes causes increased mineralization and apoptosis, Hormone and Metabolic Research, 46, (8), 2014, p537-545 Journal Article, 2014 DOI

Roche ET, Hastings CL, Lewin SA, Shvartsman DE, Brudno Y, Vasilyev NV, O'Brien FJ, Walsh CJ, Duffy GP, Mooney DJ, Comparison of biomaterial delivery vehicles for improving acute retention of stem cells in the infarcted heart., Biomaterials, 35, (25), 2014, p6850-8 Journal Article, 2014 TARA - Full Text DOI

Amato G, O'Brien F, Ghosh B, Williams, G, Simms CK, A Scaling Method for Modelling the Crashworthiness of Novel Roadside Barriers, Journal of Crashworthiness, 18, (1), 2013, p93-102 Journal Article, 2013 DOI

Holland, J.C. and Brennan, O. and Kennedy, O.D. and Rackard, S. and O'Brien, F.J. and Lee, T.C., Subchondral osteopenia and accelerated bone remodelling post-ovariectomy - a possible mechanism for subchondral microfractures in the aetiology of spontaneous osteonecrosis of the knee?, Journal of Anatomy, 222, (2), 2013, p231-238 Journal Article, 2013 DOI

Raftery, R. and O'Brien, F.J. and Cryan, S.-A., Chitosan for gene delivery and orthopedic tissue engineering applications, Molecules, 18, (5), 2013, p5611-5647 Journal Article, 2013 DOI

Amato G, O'Brien F, Ghosh B, Williams, G, Simms CK, Multibody modelling of gabion beams for impact applications, Journal of Crashworthiness, 18, (3), 2013, 237-250 Journal Article, 2013 DOI

Claro T, Widaa A, McDonnell C, Foster TJ, O'Brien FJ, Kerrigan SW, Staphylococcus aureus protein A binding to osteoblast tumour necrosis factor receptor 1 results in activation of nuclear factor kappa B and release of interleukin-6 in bone infection., Microbiology (Reading, England), 159, (Pt 1), 2013, p147-54 Journal Article, 2013 DOI TARA - Full Text

Matsiko, A. and Levingstone, T.J. and O'Brien, F.J., Advanced strategies for articular cartilage defect repair, Materials, 6, (2), 2013, p637-668 Journal Article, 2013 DOI

Murphy, C.M. and O'Brien, F.J. and Little, D.G. and Schindeler, A., Cell-scaffold interactions in the bone tissue engineering triad, European Cells and Materials, 26, 2013, p120-132 Journal Article, 2013

Holland J, Kennedy O, Brennan O, Mahony N, Rackard S, O'Brien F, Taylor D & Lee C, Examination of osteoarthritis and subchondral bone alterations within the stifle joint of an ovariectomised ovine model., Journal of Anatomy, in press, 2013 Journal Article, 2013 URL DOI

Tierney, E.G. and McSorley, K. and Hastings, C.L. and Cryan, S.-A. and O'Brien, T. and Murphy, M.J. and Barry, F.P. and O'Brien, F.J. and Duffy, G.P., High levels of ephrinB2 over-expression increases the osteogenic differentiation of human mesenchymal stem cells and promotes enhanced cell mediated mineralisation in a polyethyleneimine-ephrinB2 gene-activated matrix, Journal of Controlled Release, 165, (3), 2013, p173-182 Journal Article, 2013 DOI

McFadden, T.M. and Duffy, G.P. and Allen, A.B. and Stevens, H.Y. and Schwarzmaier, S.M. and Plesnila, N. and Murphy, J.M. and Barry, F.P. and Guldberg, R.E. and O'Brien, F.J., The delayed addition of human mesenchymal stem cells to pre-formed endothelial cell networks results in functional vascularization of a collagen-glycosaminoglycan scaffold in vivo, Acta Biomaterialia, 9, (12), 2013, p9303-9316 Journal Article, 2013 DOI

Ramesh, Ashwanth Levingstone, Tanya O'Byrne, John M. O'Brien, Fergal J. , SARS/ASIT academic & research surgery prize winner: An in vivo study of bioactive multilayered scaffolds for regeneration and repair of osteochondral defects , International Journal of Surgery , 11 , (8 ), 2013, p591 - Journal Article, 2013 DOI URL TARA - Full Text

McCoy, R.J. and Widaa, A. and Watters, K.M. and Wuerstle, M. and Stallings, R.L. and Duffy, G.P. and O'Brien, F.J., Orchestrating osteogenic differentiation of mesenchymal stem cells - Identification of placental growth factor as a mechanosensitive gene with a pro-osteogenic role, Stem Cells, 31, (11), 2013, p2420-2431 Journal Article, 2013 DOI

Amato G, O'Brien F, Ghosh B, Simms CK, Multibody modelling of a TB31 and a TB32 crash test with vertical portable concrete barriers: Model verification and sensitivity analysis, IMechE Journal of Multibody Dynamics, 227, (3), 2013, p245-260 Journal Article, 2013 DOI

Tierney, E.G. and Duffy, G.P. and Cryan, S.-A. and Curtin, C.M. and O'Brien, F.J., Non-viral gene-activated matrices: Next generation constructs for bone repair, Organogenesis, 9, (1), 2013, p158-164 Journal Article, 2013 DOI

Brennan, O. and Obrien, F.J. and McNamara, L., Estrogen plus estrogen receptor antagonists alter mineral production by osteoblasts in vitro, Hormone and Metabolic Research, 44, (1), 2012, p47-53 Journal Article, 2012 DOI

Mccoy, R.J. and O'Brien, F.J., Visualizing feasible operating ranges within tissue engineering systems using a "windows of operation" approach: A perfusion-scaffold bioreactor case study, Biotechnology and Bioengineering, 109, (12), 2012, p3161-3171 Journal Article, 2012 DOI

Curtin, C.M. and Cunniffe, G.M. and Lyons, F.G. and Bessho, K. and Dickson, G.R. and Duffy, G.P. and O'Brien, F.J., Innovative collagen nano-hydroxyapatite scaffolds offer a highly efficient non-viral gene delivery platform for stem cell-mediated bone formation, Advanced Materials, 24, (6), 2012, p749-754 Journal Article, 2012 DOI

Leszczynska, A. and Farrell, E. and O'Doherty, A. and O'Brien, F. and O'Brien, T. and Murphy, M., A comparison of endochondral ossification by vessel derived stem cells and mesenchymal stem cells in wild type and ApoE-/- mice, European Cells and Materials, 24, (SUPPL. 1), 2012, p25 Journal Article, 2012

Hoey D., Hoey D., Hoey D., Tormey S., Ramcharan S., O'Brien F., O'Brien F., Jacobs C., Primary cilia-mediated mechanotransduction in human mesenchymal stem cells, Stem Cells, 30, (11), 2012, p2561-2570 Journal Article, 2012 DOI

Widaa, A. and Claro, T. and Foster, T.J. and O'Brien, F.J. and Kerrigan, S.W., Staphylococcus aureus protein A plays a critical role in mediating bone destruction and bone loss in Osteomyelitis, PLoS ONE, 7, (7), 2012 Journal Article, 2012 DOI

Mccoy, R.J. and Jungreuthmayer, C. and O'Brien, F.J., Influence of flow rate and scaffold pore size on cell behavior during mechanical stimulation in a flow perfusion bioreactor, Biotechnology and Bioengineering, 109, (6), 2012, p1583-1594 Journal Article, 2012 DOI

O'Gorman, D.M. and Tierney, C.M. and Brennan, O. and O'Brien, F.J., The marine-derived, multi-mineral formula, aquamin, enhances mineralisation of osteoblast cells in vitro, Phytotherapy Research, 26, (3), 2012, p375-380 Journal Article, 2012 DOI

Erica G. Tierney, Garry P. Duffy, Alan J. Hibbitts, Sally-Ann Cryan, Fergal J. O'Brien, The Development of Non-Viral Gene-Activated Matrices for Bone Regeneration Using Polyethyleneimine (PEI) and Collagen-Based Scaffolds, Journal of Controlled Release, 2012 Journal Article, 2012 TARA - Full Text

Matsiko, A. and Levingstone, T.J. and O'Brien, F.J. and Gleeson, J.P., Addition of hyaluronic acid improves cellular infiltration and promotes early-stage chondrogenesis in a collagen-based scaffold for cartilage tissue engineering, Journal of the Mechanical Behavior of Biomedical Materials, 11, 2012, p41-52 Journal Article, 2012 DOI

Ciara M. Murphy, Amos Matsiko, Matthew G. Haugh, John P. Gleeson, Fergal J. O'Brien, Mesenchymal stem cell fate is regulated by the composition and mechanical properties of Collagen-Glycosaminoglycan scaffolds, Journal of the Mechanical Behavior of Biomedical Materials, 2012 Journal Article, 2012 TARA - Full Text

Presbitero G, O'Brien FJ, Lee TC and Taylor D, Distribution of microcrack lengths in bone in vivo and in vitro, Journal of Theoretical Biology , 304, 2012, p164 - 171 Journal Article, 2012 DOI

Farrell, E. and O'Brien, F.J. and van Oscha, G.J.V.M., Scaffold considerations for osteochondral tissue engineering, 2012, 779-801pp Book, 2012 DOI

Brennan, O. and Kuliwaba, J.S. and Lee, T.C. and Parkinson, I.H. and Fazzalari, N.L. and McNamara, L.M. and O'Brien, F.J., Temporal changes in bone composition, architecture, and strength following estrogen deficiency in osteoporosis, Calcified Tissue International, 91, (6), 2012, p440-449 Journal Article, 2012 DOI

O'Brien, F.J. and Harley, B.A., Editorial. Tissue engineering., Journal of the mechanical behavior of biomedical materials, 11, 2012, p1-2 Journal Article, 2012

Fat, D.L. and Kennedy, J. and Galvin, R. and O'Brien, F. and Grath, F.M. and Mullett, H., The Hounsfield value for cortical bone geometry in the proximal humerus-an in vitro study, Skeletal Radiology, 41, (5), 2012, p557-568 Journal Article, 2012 DOI

Tierney, E.G. and Duffy, G.P. and Hibbitts, A.J. and Cryan, S.-A. and O'Brien, F.J., The development of non-viral gene-activated matrices for bone regeneration using polyethyleneimine (PEI) and collagen-based scaffolds, Journal of Controlled Release, 158, (2), 2012, p304-311 Journal Article, 2012 DOI

Cox, R.F. and Jenkinson, A. and Pohl, K. and O'Brien, F.J. and Morgan, M.P., Osteomimicry of mammary adenocarcinoma cells in vitro; increased expression of bone matrix proteins and proliferation within a 3D collagen environment, PLoS ONE, 7, (7), 2012 Journal Article, 2012 DOI

Hastings, C.L. and Kelly, H.M. and Murphy, M.J. and Barry, F.P. and O'Brien, F.J. and Duffy, G.P., Development of a thermoresponsive chitosan gel combined with human mesenchymal stem cells and desferrioxamine as a multimodal pro-angiogenic therapeutic for the treatment of critical limb ischaemia, Journal of Controlled Release, 161, (1), 2012, p73-80 Journal Article, 2012 DOI

Brennan, O. and Obrien, F.J. and McNamara, L.M., Erratum: Estrogen plus estrogen receptor antagonists alter mineral production by osteoblasts in vitro (Hormone and Metabolic Research (2012) 44 (47-53) DOI: 10.1055/s-0031-1291358), Hormone and Metabolic Research, 44, (2), 2012, p154 Journal Article, 2012 DOI

Alhag, M. and Farrell, E. and Toner, M. and Claffey, N. and Lee, T.C. and O'Brien, F., Evaluation of early healing events around mesenchymal stem cell-seeded collagen-glycosaminoglycan scaffold. An experimental study in Wistar rats, Oral and Maxillofacial Surgery, 15, (1), 2011, p31-39 Journal Article, 2011 DOI

Alhag M, Farrell E, Toner M, Lee TC, O'Brien FJ, Claffey N, Evaluation of the ability of collagen-glycosaminoglycan scaffolds with or without mesenchymal stem cells to heal bone defects in Wistar rats., Oral and maxillofacial surgery, 2011 Journal Article, 2011

Duffy, G.P. and McFadden, T.M. and Byrne, E.M. and Gil, S. and Farrell, E. and O'Brien, F.J., Towards In vitro vascularisation of collagen-GAG scaffolds, European Cells and Materials, 21, 2011, p15-30 Journal Article, 2011

Tierney, E.G. and Duffy, G.P. and Cryan, S.A. and Curtin, C.M. and O'brien, F.J., The development of osteoinductive gene-activated matrices using collagen-based scaffolds, polyethyleneimine and bone morphogenetic protein 2, 2011 Conference Paper, 2011

Eric Farrell, Sanne Both, Kathrin I Ödorfer, Wendy Koevoet, Nicole Kops, Fergal J O'Brien, Robert J Baatenburg de Jong, Jan A Verhaar, Vincent Cuijpers, John Jansen, Reinhold G Erben, Gerjo JVM van Osch, In-vivo generation of bone via endochondral ossification by in-vitro chondrogenic priming of adult human and rat mesenchymal stem cells, BMC Musculoskeletal Disorders, 12, (31), 2011 Journal Article, 2011 TARA - Full Text URL DOI

Brennan, O. and Kennedy, O.D. and Lee, T.C. and Rackard, S.M. and Obrien, F.J., Effects of estrogen deficiency and bisphosphonate therapy on osteocyte viability and microdamage accumulation in an ovine model of osteoporosis, Journal of Orthopaedic Research, 29, (3), 2011, p419-424 Journal Article, 2011 DOI

Brennan MA, Gleeson JP, Browne M, O'Brien FJ, Thurner PJ, McNamara LM, Site specific increase in heterogeneity of trabecular bone tissue mineral during oestrogen deficiency., European Cells & Materials, 21, 2011, p396-406 Journal Article, 2011 URL TARA - Full Text

Haugh MG, Murphy CM, McKiernan RC, Altenbuchner C, O'Brien FJ, Crosslinking and mechanical properties significantly influence cell attachment, proliferation, and migration within collagen glycosaminoglycan scaffolds., Tissue engineering. Part A, 17, (9-10), 2011, p1201-8 Journal Article, 2011 DOI TARA - Full Text

Computational modelling in tissue engineering; providing light in times of darkness. in, editor(s)Alyssa D. Murphy , Computational Fluid Dynamics: Theory, Analysis and Applications, Nova Science Publishers., 2011, pp1 - 70, [McCoy, R., Kelly, DJ, O'Brien, F.J. ] Book Chapter, 2011

Plunkett, N. and O'Brien, F.J., Bioreactors in tissue engineering, Technology and Health Care, 19, (1), 2011, p55-69 Journal Article, 2011 DOI

Claro T, Widaa A, O'Seaghdha M, Miajlovic H, Foster TJ, O'Brien FJ, Kerrigan SW, Staphylococcus aureus Protein A Binds to Osteoblasts and Triggers Signals That Weaken Bone in Osteomyelitis., PloS one, 6, (4), 2011, pe18748 Journal Article, 2011 DOI TARA - Full Text

Fergal J O'Brien, Biomaterials and scaffolds for tissue engineering, MATERIALS TODAY, 14, (3), 2011, p88-95 Journal Article, 2011 TARA - Full Text

Brennan, O. and Kennedy, O.D. and Lee, T.C. and Rackard, S.M. and O'Brien, F.J. and McNamara, L.M., The effects of estrogen deficiency and bisphosphonate treatment on tissue mineralisation and stiffness in an ovine model of osteoporosis, Journal of Biomechanics, 44, (3), 2011, p386-390 Journal Article, 2011 DOI

Matsiko, A. and Levingstone, T.J. and O'Brien, F.J. and Gleeson, J.P., Engineering a novel collagen-based scaffold for cartilage defect repair: Compositional and structural optimisation, 2011 Conference Paper, 2011

Quinlan, E. and Partap, S. and Al-Hussona, M. and Gibbons, J. and Azevedo, M.M. and Stevens, M.M. and O'Brien, F.J., Osteogenic and angiogenic collagen-bioactive glass scaffolds for bone tissue regeneration, 2011 Conference Paper, 2011

Keogh, M.B. and Partap, S. and Daly, J.S. and O'Brien, F.J., Three hours of perfusion culture prior to 28 days of static culture, enhances osteogenesis by human cells in a collagen GAG scaffold, Biotechnology and Bioengineering, 108, (5), 2011, p1203-1210 Journal Article, 2011 DOI

Holland, J.C. and Brennan, O. and Kennedy, O.D. and Rackard, S.M. and O'Brien, F.J. and Lee, T.C., Subchondral trabecular structural changes in the proximal tibia in an ovine model of increased bone turnover, Journal of Anatomy, 218, (6), 2011, p619-624 Journal Article, 2011 DOI

Cunniffe, G.M. and O'Brien, F.J., Collagen scaffolds for orthopedic regenerative medicine, JOM, 63, (4), 2011, p66-73 Journal Article, 2011 DOI

Gleeson, J.P. and Plunkett, N.A. and O'Brien, F.J., Addition of hydroxyapatite improves stiffness, interconnectivity and osteogenic potential of a highly porous collagen-based scaffold for bone tissue regeneration, European Cells and Materials, 20, 2010, p218-230 Journal Article, 2010

Michael B. Keogh, Fergal J.O' Brien and Jacqueline S. Daly, Substrate stiffness and contractile behaviour modulate the functional maturation of osteoblasts on a collagen GAG scaffold, Acta Biomaterialia, 6, (11), 2010, p4305-4313 Journal Article, 2010 TARA - Full Text

Matsiko, A. and Levingstone, T.J. and O'Brien, F.J. and Gleeson, J.P., Addition of hyaluronic acid improves cellular infiltration and cartilage-specific extracellular matrix synthesis in a porous collagen scaffold, European Cells and Materials, 20, (SUPPL.2), 2010, p49 Journal Article, 2010

Healy C, Kennedy OD, Brennan O, Rackard SM, O'Brien FJ, Lee TC, Structural adaptation and intracortical bone turnover in an ovine model of osteoporosis., Journal of Orthopaedic Research , 28, (2), 2010, p248-51 Journal Article, 2010 DOI URL

Thorpe, S. D., Buckley, C. T., Vinardel, T., O'Brien, F. J., Campbell, V. A., Kelly, D. J. , The response of bone marrow derived mesenchymal stem cells to dynamic compression following TGF-â3 induced chondrogenic differentiation, Annals of Biomedical Engineering , 38, (9), 2010, p2896-2909 Journal Article, 2010 DOI

Stops AJ, Heraty KB, Browne M, O'Brien FJ, McHugh PE, A prediction of cell differentiation and proliferation within a collagen-glycosaminoglycan scaffold subjected to mechanical strain and perfusive fluid flow., Journal of Biomechanics, 43, (4), 2010, p618-626 Journal Article, 2010 DOI TARA - Full Text

Cunniffe GM, Dickson GR, Partap S, Stanton KT, O'Brien FJ, Development and characterisation of a collagen nano-hydroxyapatite composite scaffold for bone tissue engineering., Journal of Materials Science. Materials in Medicine, 21, (8), 2010, p2293-2298 Journal Article, 2010 URL DOI

Partap, S., Plunkett, N.A., Kelly, D.J., O'Brien, F.J. , Stimulation of Osteoblasts Using Rest Periods during Bioreactor Culture on Collagen-Glycosaminoglycan Scaffolds., Journal of Material Science, 21, (8), 2010, p2325-2330 Journal Article, 2010 DOI URL

Murphy CM, Haugh MG, O'Brien FJ, The effect of mean pore size on cell attachment, proliferation and migration in collagen-glycosaminoglycan scaffolds for bone tissue engineering., Biomaterials, 31, (3), 2010, p461-6 Journal Article, 2010 DOI URL

McCoy, R.J. and O'Brien, F.J., Influence of shear stress in perfusion bioreactor cultures for the development of three-dimensional bone tissue constructs: A review, Tissue Engineering - Part B: Reviews, 16, (6), 2010, p587-601 Journal Article, 2010 DOI

O'Brien, F.J. and O'Connell, B., Introduction to chapter IV: Biomaterials and tissue engineering, 152, 2010, pp185-186 Conference Paper, 2010 DOI

Cunniffe, G.M. and O'Brien, F.J. and Partap, S. and Levingstone, T.J. and Stanton, K.T. and Dickson, G.R., The synthesis and characterization of nanophase hydroxyapatite using a novel dispersant-aided precipitation method, Journal of Biomedical Materials Research - Part A, 95, (4), 2010, p1142-1149 Journal Article, 2010 DOI

Haugh MG, Murphy CM, O'Brien FJ, Novel Freeze-drying Methods to Produce a Range of Collagen-GAG scaffolds with Tailored Mean Pores Sizes., Tissue Engineering. Part C, Methods, (Epub ahead of print), 2010 Journal Article, 2010 DOI URL

Haugh, M.G. and Murphy, C.M. and O'Brien, F.J., Novel freeze-drying methods to produce a range of collagen- glycosaminoglycan scaffolds with tailored mean pore sizes, Tissue Engineering - Part C: Methods, 16, (5), 2010, p887-894 Journal Article, 2010 DOI

Lyons FG, Al-Munajjed AA, Kieran SM, Toner ME, Murphy CM, Duffy GP, O'Brien FJ, The healing of bony defects by cell-free collagen-based scaffolds compared to stem cell-seeded tissue engineered constructs., Biomaterials, 31, (35), 2010, p9232-43 Journal Article, 2010

Levingstone, T.J. and Dickson, G. and O'Brien, F.J. and Gleeson, J.P., A multi-layer collagen-based scaffold for osteochondral defect repair, European Cells and Materials, 20, (SUPPL.2), 2010, p47 Journal Article, 2010

Murphy, C.M. and O'Brien, F.J., Understanding the effect of mean pore size on cell activity in collagen-glycosaminoglycan scaffolds, Cell Adhesion and Migration, 4, (3), 2010, p377-381 Journal Article, 2010 DOI

Plunkett NA, Partap S, O'Brien FJ, Osteoblast response to rest periods during bioreactor culture of collagen-glycosaminoglycan scaffolds., Tissue Engineering. Part A, 16(3), 2010, p943 - 951 Journal Article, 2010 URL DOI

Khayyeri H, Checa S, Tägil M, O'Brien FJ, Prendergast PJ, Tissue differentiation in an in vivo bioreactor: in silico investigations of scaffold stiffness., Journal of Materials Science. Materials in Medicine, (Epub ahead of print), 2010 Journal Article, 2010 URL DOI

Keogh, M.B. and O'Brien, F.J. and Daly, J.S., A novel collagen scaffold supports human osteogenesis - Applications for bone tissue engineering, Cell and Tissue Research, 340, (1), 2010, p169-177 Journal Article, 2010 DOI

Stops AJ, Harrison NM, Haugh MG, O'Brien FJ, McHugh PE, Local and regional mechanical characterisation of a collagen-glycosaminoglycan scaffold using high-resolution finite element analysis., Journal of the Mechanical Behavior of Biomedical Materials, 3, (4), 2010, p292-302 Journal Article, 2010 TARA - Full Text DOI

Partap, S. and Lyons, F. and O'Brien, F.J., Scaffolds & surfaces, 152, 2010, pp187-201 Conference Paper, 2010 DOI

Plunkett, N. and O'Brien, F.J., Bioreactors in tissue engineering, 152, 2010, pp214-230 Conference Paper, 2010 DOI

Buckley CT, Thorpe SD, O'Brien FJ, Robinson AJ, Kelly DJ, The effect of concentration, thermal history and cell seeding density on the initial mechanical properties of agarose hydrogels., Journal of the Mechanical Behavior of Biomedical Materials, 2, (5), 2009, p512-21 Journal Article, 2009 DOI URL

Jungreuthmayer, C., Donahue, S.W., Jaasma, M.J., Al-Munajjed, A.A., Zanghellini, J., Kelly, D.J., O'Brien, F.J., A comparative study of shear stresses in collagen-GAG and calcium phosphate scaffolds in bone tissue-engineering bioreactors., Tissue Engineering Part A, 15, (5), 2009, p1141-1149 Journal Article, 2009 URL DOI

Jungreuthmayer, C., Donahue, S.W., Jaasma, M.J., Al-Munajjed, A.A., Zanghellini, J., Kelly, D.J., O'Brien, F.J., A comparative study of shear stresses in collagen-glycosaminoglycan and calcium phosphate scaffolds in bone tissue-engineering bioreactors, Tissue Engineering - Part A, 15, (5), 2009, p1141-1149 Journal Article, 2009

Farrell, E. and Both, S.K. and van der Jagt, O.P. and Koevoet, W. and O'Brien, F.J. and Weinans, H. and Jansen, J. and van Osch, G.J.V.M., Endochondral bone formation by adult human mesenchymal stem cells, European Cells and Materials, 18, (SUPPL. 1), 2009, p30 Journal Article, 2009

Kennedy, OD, Brennan, O, Rackard, SM, Staines, A, O'Brien, FJ, Taylor, D, Lee, TC, Effects of ovariectomy on bone turnover, porosity, and biomechanical properties in ovine compact bone 12 months postsurgery., Journal of Orthopaedic Research , 27, (3), 2009, p303 - 309 Journal Article, 2009 DOI URL

Kennedy, OD, Brennan, O, Rackard, SM, O'Brien, FJ, Taylor, D, Lee, TC, Variation of trabecular microarchitectural parameters in cranial, caudal and mid-vertebral regions of the ovine L3 vertebra., Journal of Anatomy, 214, (5), 2009, p729 - 735 Journal Article, 2009 URL DOI

Al-Munajjed AA, O'Brien FJ, Influence of a novel calcium-phosphate coating on the mechanical properties of highly porous collagen scaffolds for bone repair., Journal of the Mechanical Behavior of Biomedical Materials, 2, (2), 2009, p138-46 Journal Article, 2009 URL DOI

Buckley, C.T., Thorpe, S.D., O'Brien, F.J., Robinson, A.J., Kelly, D.J. , The effect of concentration, cooling rate and cell seeding density on the initial mechanical properties of agarose hydrogels., Mechanical Behaviour of Biomedical Materials , 2, (5), 2009, p512 - 521 Journal Article, 2009 TARA - Full Text DOI

Duffy, G.P. and Byrne, E.M. and McFadden, T.M. and Farrel, E.M. and O'Brien, F.J., In vitro vascularisation of collagen-gag scaffolds using mesenchymal stem cells, European Cells and Materials, 18, (SUPPL. 1), 2009, p16 Journal Article, 2009

Tierney CM, Jaasma MJ, O'Brien FJ, Osteoblast activity on collagen-GAG scaffolds is affected by collagen and GAG concentrations., Journal of Biomedical Materials Research. Part A, 91, (1), 2009, p92-101 Journal Article, 2009 URL DOI

Jungreuthmayer C, Jaasma MJ, Al-Munajjed AA, Zanghellini J, Kelly DJ, O'Brien FJ, Deformation simulation of cells seeded on a collagen-GAG scaffold in a flow perfusion bioreactor using a sequential 3D CFD-elastostatics model., Medical Engineering & Physics, 31, (4), 2009, p420 - 427 Journal Article, 2009 DOI URL

Al-Munajjed AA, Plunkett NA, Gleeson JP, Weber T, Jungreuthmayer C, Levingstone T, Hammer J, O'Brien FJ, Development of a biomimetic collagen-hydroxyapatite scaffold for bone tissue engineering using a SBF immersion technique., Journal of Biomedical Materials Research. Part B, Applied Biomaterials, 90, (2), 2009, p584-91 Journal Article, 2009 URL DOI

Farrell E, van der Jagt OP, Koevoet W, Kops N, van Manen CJ, Hellingman CA, Jahr H, O'Brien FJ, Verhaar JA, Weinans H, van Osch GJ, Chondrogenic Priming of Human Bone Marrow Stromal Cells: A Better Route to Bone Repair?, Tissue Engineering. Part C Methods. , 15, (2), 2009, p285-95. Journal Article, 2009 URL

Kennedy OD, Brennan O, Rackard SM, Staines A, O'Brien FJ, Taylor D, Lee TC., Effects of ovariectomy on bone turnover, porosity, and biomechanical properties in ovine compact bone 12 months postsurgery., Journal of Orthopaedic Research., 27, (3), 2009, p303 - 309 Journal Article, 2009 URL

Haugh MG, Jaasma MJ, O'Brien FJ. , The effect of dehydrothermal treatment on the mechanical and structural properties of collagen-GAG scaffolds. , Journal of Biomedical Materials Research Part A, 89, (2), 2009, p363-9. Journal Article, 2009 DOI URL

Brennan, O, Kennedy, OD, Lee, TC, Rackard, SM, O'Brien, FJ, Biomechanical properties across trabeculae from the proximal femur of normal and ovariectomised sheep., Journal of Biomechanics, 42, (4), 2009, p498 - 503 Journal Article, 2009 URL DOI

Tierney CM, Haugh MG, Liedl J, Mulcahy F, Hayes B, O'Brien FJ, The effects of collagen concentration and crosslink density on the biological, structural and mechanical properties of collagen-GAG scaffolds for bone tissue engineering., Journal of the Mechanical Behavior of Biomedical Materials, 2, (2), 2009, p202-9 Journal Article, 2009 URL DOI

O'Brien, F.J. and Lyons, F. and Al-Munajjed, A.A. and Kieran, S. and Toner, M. and Duffy, G.P., Cell-free collagen-based scaffolds enhance healing over msc-seeded in vitro-engineered bone tissue grafts, European Cells and Materials, 18, (SUPPL. 1), 2009, p25 Journal Article, 2009

McMahon LA, O'Brien FJ, Prendergast PJ., Biomechanics and mechanobiology in osteochondral tissues., Regen Med. , 3, (5), 2008, p743 - 759 Journal Article, 2008 URL

Keeley, BJ, Heidari, B, Mahony, NJ, Rackard, SM, O'Brien, FJ, Lee, TC, Brennan, O, Kennedy, OD, FitzPatrick, D, Biomechanical comparison of the pullout properties of external skeletal fixation pins in the tibiae of intact and ovariectomised ewes., Veterinary and comparative orthopaedics and traumatology : V.C.O.T, 21, (5), 2008 Journal Article, 2008

Al-Munajjed, A.A. and Gleeson, J.P. and O'Brien, F.J., Collagen/calcium-phosphate composite scaffold for bone tissue engineering, 3, 2008, pp1585 Conference Paper, 2008

Al-Munajjed, A.; Gleeson, J.P. and O'Brien, F.J. , Development of a collagen calcium-phosphate scaffold as a novel bone graft substitute, Stud Health Technol Inform, 133, 2008, p11-20 Journal Article, 2008

Jaasma M.J.; Plunkett, N.A. and O'Brien F.J., Design and validation of a dynamic flow perfusion bioreactor for use with compliant tissue engineering scaffolds, Journal of Biotechnology, 133, (4), 2008, p490 - 496 Journal Article, 2008 URL DOI

Jaasma MJ, O'Brien FJ. , Mechanical Stimulation of Osteoblasts Using Steady and Dynamic Fluid Flow, Tissue Engineering Part A, 14, (7), 2008, p1213 - 1223 Journal Article, 2008 URL DOI

Byrne EM, Farrell E, McMahon LA, Haugh MG, O'Brien FJ, Campbell VA, Prendergast PJ, O'Connell BC. , Gene expression by marrow stromal cells in a porous collagen-glycosaminoglycan scaffold is affected by pore size and mechanical stimulation. , J Mater Sci Mater Med., 19, (11), 2008, p3455 - 3463 Journal Article, 2008 URL

Kennedy OD, Brennan O, Mahony NJ, Rackard SM, O'Brien J, Taylor D, Lee C., Effects of High Bone Turnover on the Biomechanical Properties of the L3 Veretebra in an Ovine Model of Early Stage Osteoporosis, SPINE, 33, (23), 2008, p2518 - 2523 Journal Article, 2008 URL DOI

Farrell E, Wielopolski P, Pavljasevic P, van Tiel S, Jahr H, Verhaar J, Weinans H, Krestin G, O'Brien FJ, van Osch G, Bernsen M. , Effects of iron oxide incorporation for long term cell tracking on MSC differentiation in vitro and in vivo., Biochem Biophys Res Commun., 369, (4), 2008, p1076-81 Journal Article, 2008 DOI URL

Harrison NM, McDonnell PF, O'Mahoney DC, Kennedy OD, O'Brien FJ, McHugh PE. , Heterogeneous linear elastic trabecular bone modelling using micro-CT attenuation data and experimentally measured heterogeneous tissue properties. , J Biomech., 41, (11), 2008, p2589 - 2596 Journal Article, 2008 URL

S. D. Thorpe, C.T. Buckley, T Vinardell, F.J. O'Brien, V.A.Campbell and D.J. Kelly , Dynamic compression can inhibit chondrogenesis of mesenchymal stem cells, Biochemical and Biophysical Research Communications, 377, (2), 2008, p458 - 462 Journal Article, 2008

Lyons F, Partap S, O'Brien FJ., Part 1: scaffolds and surfaces., Technology and Health Care, 16, (4), 2008, p305 - 317 Journal Article, 2008 URL TARA - Full Text

Kennedy OD, Brennan O, Mauer P, Rackard SM, O'Brien FJ, Taylor D, Lee TC. , The effects of increased intracortical remodeling on microcrack behaviour in compact bone. , Bone, 43, 2008, p889 - 893 Journal Article, 2008 URL

Kennedy OD, Brennan O, Mauer P, O'Brien FJ, Rackard SM, Taylor D, Lee TC. , The behaviour of fatigue-induced microdamage in compact bone samples from control and ovariectomised sheep., Stud Health Technol Inform. , 133, 2008, p148-55 Journal Article, 2008 URL

Cunniffe, G. and Gleeson, J. and O'Brien, F.J. and Dickson, G.R., Synthesis of NanoHA for a collagen-nanoHA composite scaffold with potential for bone tissue engineering, 2, 2008, pp1063 Conference Paper, 2008

O'Brien, F.J.; Harley, B.A.; Waller, M.A.; Yannas, I.V; Gibson, L.J and Prendergast, P.J., The effect of pore size on permeability and cell attachment in collagen scaffolds for tissue engineering., Technology and Healthcare , 15, (1), 2007, p3 - 17 Journal Article, 2007 URL TARA - Full Text

Taylor, D.; Hazenberg, J.; O'Brien, F.J. and Lee, T.C. , How does bone detect cracks?, Key Engineering Materials, 348-349, 2007, p57 - 60 Journal Article, 2007 URL

O'Brien, F.J.; Taylor, D. and Lee, T.C. , Bone as a composite material: the role of osteons as barriers to crack growth in compact bone, International Journal of Fatigue, 29, 2007, p1051 - 1056 Journal Article, 2007 URL DOI

Technology and Healthcare: Special Edition: Tissue Engineering for Orthopaedic Applications , IOS Press, [eds.], 2007-2007 Editorial Board, 2007 URL

Lee, T.C., O'Brien, F.J. , Tissue engineering for orthopaedic applications, Technology and Health Care , Technology and Health Care , 15, (1), 2007, pp1-2 Conference Paper, 2007

Farrell, E., Byrne, E.M., Fischer, J., O'Brien, F.J., O'Connell, B.C., Prendergast, P.J. and Campbell, V.A, A comparison of the osteogenic potential of adult rat mesenchymal stem cells cultured in 2-D and on 3-D collagen glycosaminoglycan scaffolds. , Technology and Health Care, 15, 2007, p19 - 31 Journal Article, 2007

E. Farrell., F.J. O'Brien., P. Doyle., J. Fischer., I. Yannas., B. O'Connell., P.J. Prendergast & V.A. Campbell , A collagen-glycosaminoglycan scaffold supports adult rat mesenchymal stem cell differentiation along osteogenic and chondrogenic routes., Tissue Engineering, 12, (3), 2006, p459 - 468 Journal Article, 2006 URL DOI

Lee, T.C.; O'Brien, F.J.; Gunnlaugsson, T.; Parkesh, R. and Taylor, D. , Microdamage and bone mechanobiology, Technology and Healthcare , 14, (4-5), 2006, p359 - 365 Journal Article, 2006 URL

Mohsin, S.; O'Brien, F.J. and Lee, T.C. , Microcracks in compact bone: a three-dimensional, Journal of Anatomy , 209, (1), 2006, p119 - 124 Journal Article, 2006 URL DOI

Mohsin, S.; O'Brien, F.J. and Lee, T.C. , New embedding medium for sectioning undecalcified bone, Biotechnic & Histochemistry, 81, (2-3), 2006, p99 - 103 Journal Article, 2006 DOI URL

Mohsin, S.; O'Brien, F.J. and Lee, T.C. , Osteonal crack barriers in ovine compact bone, Journal of Anatomy, 208, (1), 2006, p81 - 89 Journal Article, 2006 URL DOI

O'Brien, F.J.; Hardiman, D.A.; Hazenberg, J.; Mercy, M.V.; Mohsin, S.; Taylor, D. and Lee, T.C., The behaviour of microcracks in compact bone, European Journal of Morphology, 42, (1-2), 2005, p71 - 79 Journal Article, 2005 URL DOI

Lee, T.C. and O'Brien, F.J. and Taylor, D. and Parkesh, R. and Gunnlaugsson, T., Visualisation and quantification of fatigue induced microdamage in bone: Histology and radiology, 1, 2005, pp473-478 Conference Paper, 2005

O'Brien, F.J.; Brennan, O.; Kennedy; O.D. and Lee, T.C., Microcracks in cortical bone: how do they affect bone biology?, Current Osteoporosis Reports , 3, 2005, p39 - 45 Journal Article, 2005 URL

O'Brien, F.J. and Taylor, D. and Lee, T.C., Breaking bones: The effect of microdamage on the fatigue behaviour of compact bone, 1, 2005, pp491-495 Conference Paper, 2005

O'Brien, F.J.; Harley, B.A.; Yannas, I.V. and Gibson, L.J. , The effect of pore size on cell adhesion in collagen-GAG scaffolds, Biomaterials, 26, 2005, p433 - 441 Journal Article, 2005 DOI URL

O'Brien, F.J.; Taylor, D and Lee, T.C., The effect of bone microstructure on the initiation and growth of microcracks. , Journal of Orthopedic Research, 23, (2), 2005, p475 - 480 Journal Article, 2005 URL DOI

Kennedy, O.D. , Brennan, O. , O'Brien, F.J. , Rackard, S.M. , Taylor, D. , Lee, T.C., The contribution of intracortical bone turnover to bone quality in osteoporosis, Proceedings of the 2005 Summer Bioengineering Conference , 2005 Summer Bioengineering Conference , 2005, 2005, pp1506-1507 Conference Paper, 2005

Microstructure and microdamage in bone. in, editor(s)G. Bischoff , Micro- and Nanostructures of Biological Systems , Aachen, Shaker Verlag, 2005, pp13 - 27, [26. Lee, T.C.; O'Brien, F.J.; Mohsin, S.; Hazenberg, J.G. and Taylor, D.] Book Chapter, 2005

Hardiman DA, O'Brien FJ, Prendergast PJ, Croke DT, Staines A, Lee TC, Tracking the changes in uploaded bone: Morphology and gene expression, European Journal of Morphology, 42, (4-5), 2005, p208 - 216 Journal Article, 2005 URL DOI

Harley, B.A., O'Brien, F.J., Yannas, I.V., Gibson, L.J., Fabrication and mechanical characterization of equiaxed collagen-GAG scaffolds, Transactions - 7th World Biomaterials Congress, 2004, pp170 Conference Paper, 2004

"Bone for life": osteoporosis, bone remodelling and computer simulation in, P.J. Prendergast and P.E. McHugh , Topics in Bio-Mechanical Engineerin, Dublin & Galway, Ireland , Trinity Centre for Bio-Engineering, Dublin and National Centre for Biomedical Engineering Science, 2004, pp58 - 93, [Lee, T.C.; McHugh, P.E.; O'Brien, F.J.; O'Mahony, D.; Taylor, D.; Bruzzi, M. ; Rackard, S.M. ; Kennedy, O.D.; Mahony N.J.; Harrison N.; Lohfield S., Brennan, O.; Gleeson J.; Hazenberg, J.G.; Mullins L.; Tyndyk, M.; McNamara, L.M. and Prendergast, P.J] Book Chapter, 2004

Moore, T.L.A.; O'Brien, F. J. and Gibson, L.J., Creep does not contribute to fatigue in bovine trabecular bone. , Journal of Biomechanical Engineering, 126, (3), 2004, p321 - 329 Journal Article, 2004 URL DOI

Scaffolds and cells: preliminary biomechanical analysis and results for the use of a collagen-gag scaffold for bone tissue engineering. in, editor(s)P.J. Prendergast and P.E. McHugh , Topics in Bio-Mechanical Engineering, Dublin & Galway, Ireland , Trinity Centre for Bio-Engineering, Dublin and National Centre for Biomedical Engineering Science, G, 2004, pp167 - 183, [30. O'Brien, F.J.; Farrell, E; Waller, M.A.; Connell, I.; O'Mahony, D.; McGarry, J.P.; Murphy, B.P.; McHugh, P.E.; Campbell, V.A. and Prendergast, P.J. ] Book Chapter, 2004

O'Brien, F.J.; Harley, B.A.; Yannas, I.V. and Gibson, , Influence of freezing rate on pore structure in freeze-dried collagen-GAG scaffolds., Biomaterials , 25 , (6), 2004, p1077 - 1086. Journal Article, 2004 DOI URL

Lee, T.C.; Mohsin, S.; Taylor, D.; Parkesh, R.; Gunnlaugsson, T.; O'Brien, F.J.; Giehl, M. and Gowin, W. , Detecting microdamage in bone , Journal of Anatomy, 203, (2), 2003, p161 - 172 Journal Article, 2003 DOI URL

O'Brien, F.J.; Lee, T.C. and Taylor, D , Microcrack accumulation at different intervals during fatigue testing of compact bone., Journal of Biomechanics , 36, (7), 2003, p973 - 980 Journal Article, 2003 URL DOI

Taylor D, O'Brien F, Lee TC , A theoretical model for the simulation of microdamage accumulation and repair in compact bone., Meccanica, 37, (4-5), 2002, p397 - 406 Journal Article, 2002 DOI URL

O'Brien, F.J.; Lee, T.C. and Taylor, D, An improved labelling technique for monitoring microcracks growth in compact bone., Journal of Biomechanics, 35, 2002, p523 - 526 Journal Article, 2002 DOI URL

Damage accumulation in bone: theory and practice. in, editor(s)J. Middleton, N.G., Shrive and M.L. Jones , In: Computer Methods in Biomechanics and Biomedical Engineering - 4 , Amsterdam, Gordon & Breach, 2002, pp386 - 391, [32. Taylor, D.; O'Brien, F.J. and Lee, T.C.] Book Chapter, 2002

Computerised three dimensional reconstruction of Haversian systems during bone remodelling. in, editor(s)J. Middleton, N.G., Shrive and M.L. Jones , Computer Methods in Biomechanics and Biomedical Engineering - 4, Amsterdam, Gordon & Breach, 2002, pp944 - 949, [33. Mohsin, S.; Mercy, M.V.; O'Brien, F.J.; Taylor, D and Lee, T.C.] Book Chapter, 2002

Microcrack growth and shape development in compact bone. in, editor(s)J. Middleton, N.G., Shrive and M.L. Jones , Computer Methods in Biomechanics and Biomedical Engineering, Amsterdam, Gordon & Breach, 2002, pp410 - 415, [31. Hazenberg, J.G.; O'Brien, F.J.; Lee, T.C. and Taylor, D] Book Chapter, 2002

Taylor D, Falsetti F, O'Brien FJ, O'Reilly P, Banville E, Lee TC , A fatigue based model of disuse osteoporosis, Computer Methods in Biomechanics and Biomedical Engineering, 4, 2001, p413-420 Journal Article, 2001 DOI URL

O'Brien FJ, Taylor D, Dickson GR, Lee TC , Visualisation of three-dimensional microcracks in compact bone. , JOURNAL OF ANATOMY, 197, (3), 2000, p413 - 420 Journal Article, 2000 URL DOI

Lee, T.C. and O'Brien, F.J. and Taylor, D., Nature of fatigue damage in bone, International Journal of Fatigue, 22, (10), 2000, p847-853 Journal Article, 2000 DOI

Microdamage in bone: a three-dimensional approach. in, editor(s)J. Middleton, M.L. Jones, N.G. Shrive and G.N. Pande , Computer Methods in Biomechanics and Biomedical Engineering , Amsterdam, Gordon & Breach, 2000, pp155 - 160, [34. O'Brien, F.J.; Taylor, D; Dickson, G.R. and Lee, T.C. ] Book Chapter, 2000

Lee TC, O'Brien FJ, Taylor D , The nature of fatigue damage in bone. , International Journal of Fatigue, 22, 2000, p847 - 853 Journal Article, 2000 DOI URL

Taylor D, O'Brien F, Prina-Mello A, Ryan C, O'Reilly P, Lee TC , Compression data on bovine bone confirms that a "stressed volume" principle explains the variability of fatigue strength results. , Journal of Biomechanics, 32, (11), 1999, p1199 - 1203 Journal Article, 1999 URL DOI

McAlinden, M.G., Magowan, J., Wilson, D.J., Insley, G., Ferris, P., Prendergast, P.J., Rice, J., Blayney, A.W., Dalstra, M., Walsh, M., McGloughlin, T., Grace, P., Colgan, D., Bray, D., McCormack, B.A.O., Reilly, R., Tancred, D., Carr, A.J., McCormack, B.A.O., Leyland, N.S., Meenan, J., Boyd, A., Akay, M., O'Dwyer, B., McCormack, B.A.O., Dunne, N.J., Ryan, K., Orr, J.F., Stungo, B., Brennan, E.G., O'Hare, N.J., Walsh, M.J., Jordan, M.F., Rasheed, A.M., Kelly, C., Kay, E., Bouchier-Hayes, D.J., Leahy, A., Maher, S.A., O'Reilly, D., Foley, J., Gillan, M.A., Cole, J.S., Raghunathan, S., O'Reilly, M.J.G., Kenny, T., Foley, J., Hourigan, T.F., Lyons, G.M., Cox, S.L., Kernohan, W.G., Fitzpatrick, C., Kernohan, W.G., Dempsey, G.J., Millar, I., Kelly, S., Charlwood, A.P., O'Brien, S., Beverland, D.E., Kavanagh, A., McGloughlin, T., Neligan, M.F., McKenna, J., Laracy, P., Moran, D., O'Beirne, J., Charlwood, A.P., Kelly, S., Nixon, J.R., Beverland, D.E., Kenny, P., Maher, S.A., Murphy, L.A., Prendergast, P.J., O'Rourke, S.K., O'Donoghue, D., Gilchrist, M.D., Caulfield, B., O'Brien, B., Simms, C., Lyons, C.G., Brady, C.L., Badran, S., Clifford, P.M., Burden, D.J., Orr, J.F., Taylor, D., Hill, R., Griffin, S., De Barra, E., Brook, I., Reytil, P., Blades, M., O'Reilly, J.P., Masterson, B.F., Macauley, D., Toner, M., Walker, J., Gillan, J., Boyd, A., Meenan, J., Akay, M., Leyland, N.S., Murphy, H., McNamara, P., Jones, E., Kelly, P., Rajah, L., Dhaif, B., Colville, J., Waide, D.V., Waide, D.V., Lawlor, G., McCormack, A., Carr, A.J., McCartney, W., McNamara, B.P., Connolly, P., Devitt, A., McElwaine, J., O'Reilly, P., Maher, S.A., Eames, M.H.A., Cosgrove, A.P., Baker, R.J., Condron, J., Coyle, E., Nugent, D., Webb, J., Black, N.D., Mclntyre, M., Lowery, M., O'Malley, M., Vaughan, L., Sweeney, P.C., Lyons, G.M., McGiven, R., Collins, A.D., Gibson, M.J., Lyons, G.M., Clernon, G.F., Wilcox, D.J., Shanahan, A., Buckley, P.J., Hanna, S., McGrellis, N., Orr, J.F., Fennel, B., Hill, R., Akinmade, A., Mitchell, A., Pintado, M.R., Douglas, W.H., Ryan, E.E., Savage, E.J., Orr, J.F., Mitchell, E., Silbermann, M., Mullett, H., Ranjith, P., Burke, T., Hill, R., Dorreil, P., Watters, E.P., Spedding, P.L., Grimshaw, J., M Bowler, D.J., Felle, P., Allen, D., McCormack, B.A.O., Moran, R., Lennon, A.B., McCormack, B.A.O., Prendergast, P.J., Thompson, N.S., Cosgrove, A.P., Baker, R.J., Saunders, J.L., Taylor, T., Grimson, J., Grimson, W., Azuaje, F., Black, N.D., Adamson, K., Lopes, P., Dubitzky, W., Wu, X., White, J., Murtagh, F., Campbell, J.G., Adamson, K., O'Tiarnaigh, R.I., Cormack, W.A., Hume, A., Starck, J.L., Lardillier, P., Kernohan, W.G., Mao, W.E., Bell, D., Chambers, M.G.A., McCammon, C., Leane, G.E., Lyons, G.M., Lyons, D.J., Lacrox, D., Murphy, L.A., Prendergast, P.J., FitzPatrick, D.P., McClorey, M., Meenen, J., O'Brien, F.J., Lee, T.C., Pellegrini, F., Dickson, G.R., Taylor, D., Royal academy of medicine in Ireland section of bioengineering - Proceedings of meeting held in dundalk, co. louth, in february 1998., Irish Journal of Medical Science, 167, (4), 1998, p256-276 Journal Article, 1998

Non-Peer-Reviewed Publications

Proceedings of Fifth Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine of Ireland , Dublin, Trinity College , [eds.], 1999 Editorial Board, 1999

Research Expertise

Description

Regenerative medicine: tissue engineering of bone and cartilage, scaffolds, bioreactors and stem cell biology. Mechanical behaviour of bone, bone remodelling, bone quality and osteoporosis.

Projects

  • Title
    • Website
  • Summary
    • See here for Project descriptions http://www.rcsi.ie/researchdb/research_piprofile.jsp?uid=62&pip=projects#themes
  • Funding Agency
    • European Research Council, SFI, Enterprise Ireland, IRCSET, Health Research Board

Keywords

Animal Model; BIODEGRADABLE IMPLANT; BIODEGRADABLE POLYMERS; Bioengineering; Biological Engineering; Biological Modeling; Biological Polymers; Biomaterials; Biomechanics; Biomechanics, Biomedical Engineering; Biomedical Engineering; Biomedical Research, Multidisciplinary; Biopolymeric Materials; Bioreactors; Biotechnology; Bone; Bone Diseases; BONE GROWTH AND DEVELOPMENT; BONE LOSS; BONE MASS; bone microdamage; BONE REGENERATION; bone remodelling and repair; BONE TURNOVER; BONE-DENSITY; BONE-RESORPTION; CARTILAGE; Cell and tissue development; Cell and tissue maintenance, repair and ageing; Cell signalling, proliferation & differentiation; Cellular Biology; Chemicals/Materials; Composite materials; Engineering underpinning biomedicine; Fatigue/Fracture; FRACTURES; Materials technology, engineering; Maxillofacial surgery; Mechanical Engineering; Mechanical Properties, Materials; Medical Devices; Medical Devices Engineering; Medical Sciences, Research; Musculoskeletal System; Orthopaedic surgery; Orthopedics; osteoporosis; SCAFFOLD; Stem Cell; Stem Cell Biology; TISSUE ADAPTATION; Tissue Culture; tissue engineering

Recognition

Representations

See here: http://www.rcsi.ie/researchdb/research_piprofile.jsp?uid=62&pip=team#themes

Awards and Honours

Engineers Ireland, Chartered Engineer of the Year Award 2005

Science Foundation Ireland, President of Ireland Young Researcher Award 2004

New Investigator Recognition Award for Outstanding Scientific Paper, 48th Annual Meeting of the Orthopaedic Research Society, Dallas, Texas 2002

Fulbright Scholarship 2001

Co-author on paper which won Genzyme Award for Excellence in Cartilage Research 2007, ?Tracking bone marrow stromal cells with iron oxide labelling and its effects on multilineage differentiation potential?, International Cartilage Repair Society 2007

Appointed as a Subject Editor (Tissue Engineering) for the Journal of the Mechanical Behavior of Biomedical Materials., Journal of the Mechanical Behavior of Biomedical Materials (Elsevier) 2007

Appointed to Editorial Board of Journal of Biomechanics. 2009

Starting Independent Researcher Grant by the European Research Council (2million Euro) 2009

Memberships

Member of the Institution of Engineers of Ireland Chartered Engineer, 2005 1996 – present

Member of the European Society for Engineering and Medicine Council Member, 2004 Newsletter Editor, 2004 Website Editor, 2004 2002 – present

Member of the European Society of Biomechanics 2002 – present

Member of the American Society for Bone and Mineral Research 2005 – present

Member of the Anatomical Society of Great Britain and Ireland 2003 – present

Member of the Irish Fulbright Alumni Association 2003 – present