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Dr. Ismael Obaidi
Research Fellow, Pharmacy

Biography

Ismael Obaidi is a specialist pharmacist graduated from the University of Kufa/Iraq with an honour degree in Pharmacy and Pharmaceutical Sciences in 2005. He awarded M.Sc. in Pharmacology and Toxicology from the School of Medicine/ University of Babylon/Iraq in 2011. His research unravelled the antibiotic sensitising potential and immunomodulatory effect of surface-active agents against the world's most antibiotic-resistant bacteria including MRSA and pseudomonas aeruginosa. Under the supervision of Prof. Tara McMorrow at University College Dublin/Ireland, he completed his Ph.D. in Molecular Toxicology and Cancer Research focusing on three models; cytotoxicity-driven cellular regrowth programming, chemosensitisation of drug-resistant cancerous cells to TNF-related apoptosis inducing ligand (TRAIL)-induced apoptosis, and harnessing a successful and robust in vivo model of cancer engraftment using zebrafish. In 2018, he joined Cell Technology Research Group/ National Institute of Bioprocessing, Research and Training (NIBRT)/Dublin/Ireland led by Prof. Michael Butler as a postdoctoral researcher focusing on developing cell culture media to improve IgG-producing Chinese Ovary Hamster (CHO) cell growth and productivity using plant-derived protein hydrolysates and their fractionated bioactive peptones. In 2020, he joined NatPro Natural Research Centre/ Trinity College Dublin/Ireland as a research fellow investigating the anti-inflammatory activities of bogs-derived plant extracts using lipopolysaccharide (LPS)-inducing TLR4 pathway. His research papers and review articles have been published in Advanced Biotechnology, International Journal of Molecular Sciences, and other prestigious journals. He was awarded the Iona Pratt medal for excellence in Toxicology, Irish Toxicology Society 2017.

Publications and Further Research Outputs

Non-Peer-Reviewed Publications

I Obaidi, H Cassidy, VI Gaspar, J McCaul, M Higgins, M Halász,, Curcumin Sensitizes Kidney Cancer Cells to TRAIL-Induced Apoptosis via ROS Mediated Activation of JNK-CHOP Pathway and Upregulation of DR4, Biology , 2020 Journal Article, 2020

R O'Flaherty, A Bergin, E Flampouri, LM Mota, I Obaidi, A Quigley, Y Xie,, Mammalian cell culture for production of recombinant proteins: A review of the critical steps in their biomanufacturing, Biotechnology Advances, 2020 Journal Article, 2020

M Higgins, I Obaidi, T McMorrow, Primary cilia and their role in cancer, Oncology letters, 2019 Journal Article, 2019

I Obaidi, M Higgins, B Bahar, JL Davis, T McMorrow, Identification of the multifaceted chemopreventive activity of curcumin against the carcinogenic potential of the food additive, KBrO3, Current pharmaceutical design, 2018 Journal Article, 2018

Cancer, Carcinogens and Screening in the Kidney in, Cancer Causing Substances, 2018, [M Higgins, I Obaidi, T McMorrow] Book Chapter, 2018

I Obaidi, MMMT Higgins, Dysregulation of apoptosis-regulating miRNA by curcumin sensitizes kidney cancer cells to TRAIL induced apoptosis, 2017 Oral Presentation, 2017

I Obaidi, T McMorrow, A comparison between the effect of natural and synthetic chemopreventive agents against potassium bromate-induced carcinogenic effects on human renal proximal epithelial cells, 2017 Poster, 2017

Obaidi, I and McMorrow , Curcumin sensitizes kidney cancer cells to TRAIL induced apoptosis via activation of ROS/JNK/CHOP and ROS/DR4 pathways, 7th World Cancer & Tumor Conference & Expo, 2017 Oral Presentation, 2017

Obaidi I, McMorrow T, The multifaceted activity of curcumin in cancer chemoprevention and anticancer treatment., Irish Association of Pharmacologists, 2016 Poster, 2016

Obaidi, I and McMorrow T, Targeting renal cell carcinoma with curcumin sensitizes the cells to TRAIL-induced apoptosis, UCD Conway Festival of research and Innovation , 2016 Poster, 2016

I Obaidi, T Mcmorrow, Renal cell carcinoma models: Effect of chemopreventative agents on the carcinogenic potential of potassium bromate in human renal epithelial cells, 52rd Congress of the European Societies of Toxicology, 2016 Poster, 2016

Obaidi, I., Higgins M and McMorrow, T, Curcumin sensitizes renal cell carcinoma to TRAIL-induced apoptosis. . Abstract for poster, Cell Death and its Translational Ramification conference, 2016 Poster, 2016

Obaidi, I and McMorrow, T, The carcinogenic potential of potassium bromate on normal RPTEC/TERT1kidney epithelial cells; insights into mechanisms of ciliary and DNA dysfunction, Cilia, Cytoskeleton and Cancer conference, 2016 Poster, 2016

Research Expertise

Description

I am interested in working on cancer research, particularly cancer chemoprevention and treatment. My research focus on three different aspects; cytotoxicity-driven regrowth programming model, re-sensitization of drug-resistant cancerous cells using phytochemicals, and in vivo model of xenotransplantation of cancerous cells. I am also fascinated in investigating the molecular carcinogenesis driven by chemical carcinogens, particularly genotoxic carcinogens. I have also a considerable interest in epigenetic regulation of gene expression particularly miRNA. Further, I am keen on working with xenotransplantation of Zebra fish

Keywords

Anticancer therapies; Biotechnology; Cancer Biology; miRNA; MOLECULAR-BIOLOGY; Toxicology; TUMOR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGAND; ZEBRAFISH

Recognition

Awards and Honours

Winning the Iona Pratt medal for excellence in Toxicology, Irish Society of Toxicology 2017

Memberships

Members of international cell death society Members of Irish Toxicology society 2015 – 2018