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Dr. Peter Lavin
Clinical Associate Professor, Clinical Medicine

Biography

Dr. Lavin is Consultant Nephrologist and General Internal Medicine Physician in Tallaght University Hospital. He is also a Clinical Senior Lecturer in Clinical Medicine in Trinity College Dublin.

He graduated from the Royal College of Surgeons in Ireland in 1998. He continued postgraduate training in Ireland in Internal Medicine and Nephrology, before completing a Nephrology Fellowship in Duke University Medical Center, NC, USA. He also worked in the Duke University Center for Human Genetics (2006-2011) where he researched autosomal dominant hereditary kidney disease (FSGS, C3 glomerulopathy and Interstitial Nephritis) using molecular genetics techniques.

He returned to Ireland to practice as a Nephrologist at Tallaght Hospital in 2011 where his clinical interests are Familial Kidney Disease, Diabetic Kidney Disease, Glomerular Kidney Disease, C3 Glomerulopathy, Acute Kidney Injury and Intensive Care Nephrology.

Publications and Further Research Outputs

Peer-Reviewed Publications

Connaughton DM, Kennedy C, Shril S, Mann N, Murray SL, Williams PA, Conlon E, Nakayama M, van der Ven AT, Itself H, Kause F, Kolvenbach CM, Dai R, Vivante A, Braun DA, Schneider R, Kitzler TM, Moloney B, Moran CP, Smyth JS, Kennedy A, Benson K, Stapleton C, Denton M, Magee C, O'Seaghdha CM, Plant WD, Griffin MD, Awan A, Sweeney C, Mane SM, Lifton RP, Griffin B, Leavey S, Casserly L, de Freitas DG, Holian J, Dorman A, Doyle B, Lavin PJ, Little MA. Conlon PJ, Hildebrandt F., Monogenic causes of chronic kidney disease in adults, Kidney International, 95, (4), 2019, p914 - 928 Journal Article, 2019 DOI

Kennedy C, Connaughton DM, Murray S, Ormond J, Butler A, Phelan E, Young J, Durack L, Flavin J, O'Grady M, O'Kelly P, Lavin P, Leavey S, Lappin D, Giblin L, Casserly L, Plant WD, Conlon PJ, Home haemodialysis in Ireland, QJM: An International Journal of Medicine, 111, (4), 2018, p225 - 229 Journal Article, 2018 URL

Zivná M, Kidd K, Přistoupilová A, Bare ová V, DeFelice M, Blumenstiel B, Harden M, Conlon P, Lavin P, Connaughton DM, Hartmannová H, Hodaňová K, Stránecký V, Vrbacká A, Vyleťal P, ivný J, Votruba M, Sovová J, Hůlková H, Robins V, Perry R, Wenzel A, Beck BB, Seeman T, Viklický O, Rajnochová-Bloudíčková S, Papagregoriou G, Deltas CC, Alper SL, Greka A, Bleyer AJ, Kmoch S, Noninvasive Immunohistochemical Diagnosis and Novel MUC1 Mutations Causing Autosomal Dominant Tubulointerstitial Kidney Disease., Journal of the American Society of Nephrology, 29, 2018 Journal Article, 2018 DOI URL TARA - Full Text

Corrigan C, Peterson L, McVeigh C, Lavin PJ, Mellotte GJ, Wall C, Baker Kerrigan A, Barnes L, O'Neill D, Moss H, The Perception of Art among Patients and Staff on a Renal Dialysis Unit, Ir Med J, 110, (9), 2017, pP633 Journal Article, 2017 URL

O'Shaughnessy M, Allen N, Davin D, Mentre L, O'Regan J, Payne Danson E, Lavin P, Grimes T , Agreement Between Renal Prescribing References and Determination of Prescribing Appropriateness in Hospitalised Patients with Chronic Kidney Disease, QJM An International Journal of Medicine, 2017 Journal Article, 2017 DOI URL

Gunning H, Taylor G, Smyth A, Mellotte G, Fennell J, Murphy P, Lavin P, Wall C, An Approach to Optimise Therapeutic Vancomycin Dosage in a Haemodialysis Population., Irish Medical Journal, 109, (9), 2016, p465- Journal Article, 2016

Wong L, Moran S, Lavin PJ, Dorman AM, Conlon PJ, Kidney transplant outcomes in familial C3 glomerulopathy, Clinical Kidney Journal, 9, (3), 2016, p403 - 407 Journal Article, 2016 URL

Hall G, Gbadegesin RA, Lavin P, Wu G, Liu Y, Oh EC, Wang L, Spurney RF, Eckel J, Lindsey T, Homstad A, Malone AF, Phelan PJ, Shaw A, Howell DN, Conlon PJ, Katsanis N, Winn MP, A novel missense mutation of Wilms' Tumor 1 causes autosomal dominant FSGS, Journal of the American Society of Nephrology, 26, (4), 2015, p831 - 843 Journal Article, 2015 DOI URL

Connaughton DM, Bukhari S, Conlon P, Cassidy E, O'Toole M, Mohamad M, Flanagan J, Butler T, O'Leary A, Wong L, O'Regan J, Moran S, O'Kelly P, Logan V, Griffin B, Griffin M, Lavin P, Little MA, Conlon P., The Irish Kidney Gene Project, Nephron, 130, (4), 2015, p293 - 301 Journal Article, 2015 DOI URL

Wong L, Kok HK, Akib RR, Lavin PJ, Torreggiani WC., An unusual cause for loin pain., Kidney International, 88, (3), 2015, p644 - 644 Journal Article, 2015 DOI URL

Hall G, Rowell J, Farinelli F, Gbadegesin RA, Lavin P, Wu G, Homstad A, Malone A, Lindsey T, Jiang R, Spurney R, Tomaselli GF, Kass DA, Winn MP, Phosphodiesterase 5 inhibition ameliorates angiontensin II-induced podocyte dysmotility via the protein kinase G-mediated downregulation of TRPC6 activity., American journal of physiology. Renal physiology, 306, (12), 2014, pF1442-50 Journal Article, 2014 DOI URL

Gbadegesin RA, Hall G, Adeyemo A, Hanke N, Tossidou I, Burchette J, Wu G, Homstad A, Sparks MA, Gomez J, Jiang R, Alonso A, Lavin P, Conlon P, Korstanje R, Stander MC, Shamsan G, Barua M, Spurney R, Singhal PC, Kopp JB, Haller H, Howell D, Pollak MR, Shaw AS, Schiffer M, Winn MP, Mutations in the Gene That Encodes the F-Actin Binding Protein Anillin Cause FSGS., Journal of the American Society of Nephrology : JASN, 2014 Journal Article, 2014 URL DOI

O'Shaughnessy MM, O'Regan JA, Lavin P, Prevention of Sudden Cardiac Death in Hemodialysis Patients., Cardiovascular & hematological disorders drug targets, 2014 Journal Article, 2014 URL DOI

Pickering MC, D'Agati VD, Nester CM, Smith RJ, Haas M, Appel GB, Alpers CE, Bajema IM, Bedrosian C, Braun M, Doyle M, Fakhouri F, Fervenza FC, Fogo AB, Frémeaux-Bacchi V, Gale DP, Goicoechea de Jorge E, Griffin G, Harris CL, Holers VM, Johnson S, Lavin PJ, Medjeral-Thomas N, Paul Morgan B, Nast CC, Noel LH, Peters DK, Rodríguez de Córdoba S, Servais A, Sethi S, Song WC, Tamburini P, Thurman JM, Zavros M, Cook HT, C3 glomerulopathy: consensus report., Kidney international, 2013 Journal Article, 2013 DOI TARA - Full Text URL

Gbadegesin RA, Brophy PD, Adeyemo A, Hall G, Gupta IR, Hains D, Bartkowiak B, Rabinovich CE, Chandrasekharappa S, Homstad A, Westreich K, Wu G, Liu Y, Holanda D, Clarke J, Lavin P, Selim A, Miller S, Wiener JS, Ross SS, Foreman J, Rotimi C, Winn MP, TNXB mutations can cause vesicoureteral reflux., Journal of the American Society of Nephrology : JASN, 24, (8), 2013, p1313-22 Journal Article, 2013 DOI URL

Gbadegesin RA, Lavin PJ, Hall G, Bartkowiak B, Homstad A, Jiang R, Wu G, Byrd A, Lynn K, Wolfish N, Ottati C, Stevens P, Howell D, Conlon P, Winn MP, Inverted formin 2 mutations with variable expression in patients with sporadic and hereditary focal and segmental glomerulosclerosis., Kidney international, 81, (1), 2012, p94-9 Journal Article, 2012 URL DOI

Malik TH, Lavin PJ, Goicoechea de Jorge E, Vernon KA, Rose KL, Patel MP, de Leeuw M, Neary JJ, Conlon PJ, Winn MP, Pickering MC, A hybrid CFHR3-1 gene causes familial C3 glomerulopathy, Journal of the American Society of Nephrology, 23, (7), 2012, p1155 - 1160 Journal Article, 2012 DOI URL

Eckel J, Lavin PJ, Finch EA, Mukerji N, Burch J, Gbadegesin R, Wu G, Bowling B, Byrd A, Hall G, Sparks M, Zhang ZS, Homstad A, Barisoni L, Birbaumer L, Rosenberg P, Winn MP, TRPC6 enhances angiotensin II-induced albuminuria., Journal of the American Society of Nephrology : JASN, 22, (3), 2011, p526-35 Journal Article, 2011 DOI URL

LAVIN PJ, WINN MP., TORCing up the importance of calcium signaling., Journal of the American Society of Nephrology, 22, (8), 2011, p1391 - 1393 Journal Article, 2011 URL DOI TARA - Full Text

Luo X, Hall G, Li S, Bird A, Lavin PJ, Winn MP, Kemper AR, Brown TT, Koeberl DD, Hepatorenal correction in murine glycogen storage disease type I with a double-stranded adeno-associated virus vector., Molecular therapy : the journal of the American Society of Gene Therapy, 19, (11), 2011, p1961-70 Journal Article, 2011 URL DOI

G Hall, J Eckel, P Lavin, R Gbadegesin, G Wu, MP Winn, DEFINING THE TRANSCRIPTIONAL REGULATION OF ANGIOTENSIN II-INDUCED TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, TYPE 6 EXPRESSION IN MURINE PODOCYTES, JOURNAL OF INVESTIGATIVE MEDICINE, 12. American Federation for Medical Research, Southern Regional Meeting , New Orelans, 2011, 59, (2), 2011, pp498 - 499 Conference Paper, 2011

Gbadegesin R, Lavin P, Foreman J, Winn M, Pathogenesis and therapy of focal segmental glomerulosclerosis: an update., Pediatric nephrology (Berlin, Germany), 26, (7), 2011, p1001-15 Journal Article, 2011 DOI URL

Akilesh S, Suleiman H, Yu H, Stander MC, Lavin P, Gbadegesin R, Antignac C, Pollak M, Kopp JB, Winn MP, Shaw AS, Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis., The Journal of clinical investigation, 121, (10), 2011, p4127-37 Journal Article, 2011 URL DOI

Gbadegesin R, Lavin P, Janssens L, Bartkowiak B, Homstad A, Wu G, Bowling B, Eckel J, Potocky C, Abbott D, Conlon P, Scott WK, Howell D, Hauser E, Winn MP, A new locus for familial FSGS on chromosome 2p., Journal of the American Society of Nephrology : JASN, 21, (8), 2010, p1390-7 Journal Article, 2010 DOI URL

Gbadegesin R, Bartkowiak B, Lavin PJ, Mukerji N, Wu G, Bowling B, Eckel J, Damodaran T, Winn MP, Exclusion of homozygous PLCE1 (NPHS3) mutations in 69 families with idiopathic and hereditary FSGS., Pediatric nephrology (Berlin, Germany), 24, (2), 2009, p281-5 Journal Article, 2009 URL DOI

O'Seaghdha CM, McQuillan R, Moran AM, Lavin P, Dorman A, O'Kelly P, Mohan DM, Little P, Hickey DP, Conlon PJ, Higher tacrolimus trough levels on days 2-5 post-renal transplant are associated with reduced rates of acute rejection., Clinical transplantation, 23, (4), 2009, p462-8 Journal Article, 2009 DOI URL

Lavin PJ, Gbadegesin R, Damodaran TV, Winn MP, Therapeutic Targets in FSGS, Current Opinion in Nephrology and Hypertension, 17, (4), 2008, p386 - 392 Journal Article, 2008 URL DOI

Malone A, McConkey S, Dorman A, Lavin P, Gopthanian D, Conlon P, Mycobacterium tuberculosis in a renal transplant transmitted from the donor., Irish journal of medical science, 176, (3), 2007, p233-5 Journal Article, 2007 URL DOI

Lavin PJ, Laing ME, O'Kelly P, Moloney FJ, Gopinathan D, Aradi AA, Shields DC, Murphy GM, Conlon PJ, Improved renal allograft survival with vitamin D receptor polymorphism., Renal failure, 29, (7), 2007, p785-9 Journal Article, 2007 DOI URL

Ryan JG, Morgan RK, Lavin PJ, Murray FE, O'Connell PG, Current management of corticosteroid-induced osteoporosis: variations in awareness and management., Irish journal of medical science, 173, (1), 2005, p20-2 Journal Article, 2005

Research Expertise

Keywords

Chronic Kidney Disease; COMPLEMENT ACTIVATION; FAMILIAL INTERSTITIAL NEPHRITIS; Genetic Kidney Disease; INHERITED FSGS; INTERSTITIAL NEPHRITIS; Kidney Disease

Recognition

Representations

Clinical Director, Medical Directorate Tallaght University Hospital 01/07/2019

Clinical Lead in Nephrology, Tallaght University Hospital 2018-

Regional Lead for Dublin Milands Hospital Group in Nephrology 2018-

Honorary Secretary Irish Nephrology Society 2014

Member of National Renal Intelligence Advisory Group 2017 -

Chairman, Joint Tallaght Hospital and St James's Hospital Research Ethics Committee 2015

Member of Joint Tallaght Hospital and St James's Hospital Research Ethics Committee Jan, 2015

Member on Nephrology Specialist Training Committee (STC), Royal College of Physicians in Ireland 2015 -

Awards and Honours

Henry Christian Award - American Federation of Medical Research April 2010

Memberships

Irish Nephrology Society 01/08/2011 – Present

American Society of Nephrology 01/01/2007 – Present

Fellowship of the Royal College of Physicians in Ireland 2015 – Present

Membership of Royal College of Physicians in Ireland 2000 – present