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Professor Jacintha O'Sullivan
Professor, Surgery

Publications and Further Research Outputs

Peer-Reviewed Publications

Brennan, L., Sadeghi, F., O'Neill, L., Guinan, E., Smyth, L. Sheill, G., Smyth, E., Doyle, S.L., Timon, C., Connolly, D., O'Sullivan, J., Reynolds, J.V., and Hussey, J., Telehealth Delivery of a Multi-Disciplinary Rehabilitation Programme for Upper Gastro-Intestinal Cancer: ReStOre@Home Feasibility Study, Cancers, 2022 Journal Article, 2022 DOI

E. Flis, G. Barber, C. Nulty, B. Keogh, P. McGuirk, A. Anand, J. O'Sullivan, M. Quante, E.M. Creagh. , Identification of TLR2 signalling mechanisms which Contribute to Barrett's and Oesophageal Adenocarcinoma Disease Progression, Cancers (Basel) , 13, (9), 2021, p2065 - 2081 Journal Article, 2021 DOI

Kennedy, S.A., Annett, S.L., Dunne, M.R., Boland, F., O'Neill, L.M., Guinan, E.M., Doyle, S.L., Foley, E.K., Elliott, J.A., Murphy, C.F., Bennett, A.E., Carey, M., Hillary, D., Robson, T., Reynolds, J.V., Hussey, J., O'Sullivan, J.N., Effect of the Rehabilitation Program, ReStOre, on Serum Biomarkers in a Randomized Control Trial of Esophagogastric Cancer Survivors, Frontiers in Oncology, 11, (669078), 2021, p1-11 Journal Article, 2021 DOI

Bennett, A.E., O'Neill, L., Connolly, D., Guinan, E., Boland, L., Doyle, S., O'Sullivan, J., Reynolds, J.V., Hussey, J., Perspectives of Esophageal Cancer Survivors on Diagnosis, Treatment, and Recovery., Cancers, 13, (1), 2021, p1-12 Journal Article, 2021 DOI URL

O'Neill L., Guinan E., Doyle S., O'Connor L., Sheill G., Smyth E., Fairman C., Segurado R., Connolly D., O'Sullivan J., Reynolds JV., Hussey J, ReStOre@Home: Feasibility study of a virtually delivered 12-week multidisciplinary rehabilitation programme for survivors of upper gastrointestinal (UGI) cancer - study protocol, HRB Open Research, 2020 Journal Article, 2020 DOI

Cannon, A. and Clarke, N. and MacCarthy, F. and Dunne, C. and Kevans, D. and Mahmud, N. and Lysaght, J. and O'Sullivan, J., Effect of cigarette smoke extract on the intestinal microenvironment of ulcerative colitis tissue, JGH Open, 4, (6), 2020, p1191-1198 Journal Article, 2020 DOI TARA - Full Text

Buckley AM, Dunne MR, Morrissey ME, Kennedy SA, Nolan A, Davern M, Foley EK, Clarke N, Lysaght J, Ravi N, O'Toole D, MacCarthy F, Reynolds JV, Kennedy BN, O'Sullivan J., Real-time metabolic profiling of oesophageal tumours reveals an altered metabolic phenotype to different oxygen tensions and to treatment with Pyrazinib., Scientific reports, 10, (1), 2020, p12105 Journal Article, 2020 DOI TARA - Full Text

Azizah M. Malebari, Darren Fayne, Seema M. Nathwani, Fiona O'Connell, Sara Noorani, Brendan Twamley, Niamh M. O'Boyle, Jacintha O'Sullivan, Daniela M. Zisterer, Mary J. Meegan, Beta-lactams with antiproliferative and antiapoptotic activity in breast and chemoresistant colon cancer cells, European Journal of Medicinal Chemistry, 189, 2020, p112050- Journal Article, 2020 DOI URL

O'NEILL L., GUINAN E., DOYLE S., CONNOLLY D., O'SULLIVAN J., BENNETT A., SHEILL G., SEGURADO R., KNAPP P., FAIRMAN C., NORMAND C., GEOGHEGAN J., CONLON K., REYNOLDS JV., HUSSEY J., Rehabilitation strategies following oesophagogastric and hepatopancreaticobiliary cancer (ReStOre II): a protocol for a randomised controlled trial, BMC Cancer, 20, 2020, p1 - 20 Journal Article, 2020 DOI

G. Barber, A. Anand, K. Oficjalska, J.J. Phelan, A. B. Heeran, E. Flis, N. E. Clarke, J. A. Watson, J. Strangmann, B. Flood, H. O'Neill, D. O'Toole, F. MacCarthy, N. Ravi, J. V. Reynolds, E.W. Kay, M. Quante, J. O'Sullivan, E.M. Creagh., Characterizing caspase-1 involvement during esophageal disease progression. , Cancer Immunology Immunotherapy, 69, (12), 2020, p2635 - 2649 Journal Article, 2020 DOI TARA - Full Text

Guinan, E.M., Bennett, A.E., Doyle, S.L., O'Neill, L, Gannon, J., Foley, G., Elliott, J.A., O'Sullivan, J., Reynolds, J.V., & Hussey, J., Measuring the impact of oesophagectomy on physical functioning and physical activity participation: a prospective study, BMC Cancer, 19, (682), 2019 Journal Article, 2019 DOI TARA - Full Text URL

Butler, C.T. and Kennedy, S.A. and Buckley, A. and Doyle, R. and Conroy, E. and Gallagher, W.M. and O'Sullivan, J. and Kennedy, B.N., 1,4-dihydroxy quininib attenuates growth of colorectal cancer cells and xenografts and regulates the TIE-2 signaling pathway in patient tumours, Oncotarget, 10, (38), 2019, p3725-3744 Journal Article, 2019 DOI TARA - Full Text

Buckley AM, Dunne MR, Lynam-Lennon N, Kennedy SA, Cannon A, Reynolds AL, Maher SG, Reynolds JV, Kennedy BN, O'Sullivan J., Pyrazinib (P3), [(E)-2-(2-Pyrazin-2-yl-vinyl)-phenol], a small molecule pyrazine compound enhances radiosensitivity in oesophageal adenocarcinoma., Cancer letters, 447, 2019, p115-129 Journal Article, 2019 DOI

O'Neill L., Knapp P., Doyle SL., Guinan E., Parker A.,Segurado R., Connolly D., O'Sullivan J., Reynolds JV., Hussey J, 'Patient and family co-developed participant information to improve recruitment rates, retention, and patient understanding in the Rehabilitation Strategies Following Oesophago-gastric and Hepatopancreaticobiliary Cancer (ReStOre II) trial: Protocol for a study within a trial (SWAT) [version 1; peer review: awaiting peer review]', 2019, - Protocol or guideline, 2019 DOI

Melo, Ashanty M., O'Brien, Aisling M., Phelan, James J., Kennedy, Susan A., Wood, Nicole A. W., Veerapen, Natacha, Besra, Gurdyal S., Clarke, Niamh E., Foley, Emma K., Ravi, Akshaya, MacCarthy, Finbar, O'Toole, Dermot, Ravi, Narayamasami, Reynolds, John V., Conroy, Melissa J., Hogan, Andrew E., O'Sullivan, Jacintha, Dunne, Margaret R., Mucosal-Associated Invariant T Cells Display Diminished Effector Capacity in Oesophageal Adenocarcinoma, Frontiers in Immunology, 10, 2019 Journal Article, 2019 DOI TARA - Full Text

Sinead A. Noonan*, Maria E. Morrissey*, Petra Martin, Monika Biniecka, Shane Ó'Meachair, Aoife Maguire, Miriam Tosetto, Blathnaid Nolan, John Hyland, Kieran Sheahan, Diarmuid O'Donoghue, Hugh Mulcahy, David Fennelly, Jacintha O'Sullivan, Tumour vasculature immaturity, oxidative damage and systemic inflammation stratify survival of colorectal cancer patients on bevacizumab treatment, Oncotarget, 9, 2018, p10536 - 10548 Journal Article, 2018 DOI TARA - Full Text URL

Buckley AM, Lynam-Lennon N, Kennedy SA, Dunne MR, Aird JJ, Foley EK, Clarke N, Ravi N, O'Toole D, Reynolds JV, Kennedy BN, O'Sullivan J., Leukaemia inhibitory factor is associated with treatment resistance in oesophageal adenocarcinoma., Oncotarget, 9, (72), 2018, p33634-33647 Journal Article, 2018 TARA - Full Text DOI

Guinan, E.M., Doyle, S.L., Bennett, A.E., O'Neill, L, Gannon, J., Elliott, J.A., O'Sullivan, J., Reynolds, J.V., & Hussey, J., Sarcopenia during neoadjuvant therapy for oesophageal cancer: characterising the impact on muscle strength and physical performance, Supportive Care in Cancer, 26, (5), 2018, p1569 - 1576 Journal Article, 2018 DOI URL

Bennett, A.E., O'Neill, L., Connolly, D., Guinan, E.M., Boland, L., Doyle, S.L., O'Sullivan, J., Reynolds, J.V., & Hussey, J., Patient experiences of a physiotherapy-led multidisciplinary rehabilitative intervention after successful treatment for oesophago-gastric cancer, Supportive Care in Cancer, 26, (8), 2018, p2615 - 2623 Journal Article, 2018 URL DOI

James J. Phelan, Finbar MacCarthy, Dermot O'Toole, Narayanasamy Ravi, John V. Reynolds and Jacintha O'Sullivan, The Mitochondrial Genes BAK1, FIS1 and SFN are Linked with Alterations in Mitochondrial Membrane Potential in Barrett's Esophagus, International Journal of Molecular Sciences, 19, (11), 2018 Journal Article, 2018 URL TARA - Full Text DOI

O'Neill, L.M., Guinan, E., Doyle, S.L., Bennett, A.E., Murphy, C., Elliott, J.A., O'Sullivan, J., Reynolds, J.V., Hussey, J., The RESTORE Randomized Controlled Trial: Impact of a multidisciplinary rehabilitative program on cardiorespiratory fitness in esophagogastric cancer survivorship, Annals of Surgery, 268, (5), 2018, p747 - 755 Journal Article, 2018 DOI URL

Donohoe C.L, Lysaght J, O'Sullivan J, Reynolds J.V, Emerging Concepts Linking Obesity with the Hallmarks of Cancer, Trends in Endocrinology and Metabolism, 28, (1), 2017, p46 - 62 Journal Article, 2017 DOI URL

Butler C.T, Reynolds A.L, Tosetto M, Dillon E.T, Guiry P.J, Cagney G, O'Sullivan J, Kennedy B.N, A quininib analogue and cysteinyl leukotriene receptor antagonist inhibits vascular endothelial growth factor (VEGF)-independent angiogenesis and exerts an additive antiangiogenic response with bevacizumab, Journal of Biological Chemistry, 292, (9), 2017, p3552 - 3567 Journal Article, 2017 URL DOI

Prichard David O, Byrne Anne Marie, Murphy James O, Reynolds John V, O'Sullivan Jacintha, Feighery Ronan, Doyle Brendan, Eldin Osama Sharaf, Finn Stephen P, Maguire Aoife, Duff Deirdre, Kelleher Dermot P, Long Aideen, Deoxycholic acid promotes development of gastroesophageal reflux disease and Barrett's oesophagus by modulating integrin-αv trafficking , Journal of cellular and molecular medicine , 21 , (12 ), 2017, p3612 - 3625 Journal Article, 2017 TARA - Full Text URL DOI

Linda O'Neill, Emer Guinan, Suzanne L Doyle, Jessie A. Elliott, Jacintha O'Sullivan, John V. Reynolds, Juliette Hussey, Rehabilitation Strategies following esophageal cancer (the ReStOre trial): a feasibility study, Diseases of the Esophagus, 30, (5), 2017, p1 - 8 Journal Article, 2017 DOI

Moriarity A, O'Sullivan J, Kennedy J, Mehigan B, McCormick P, Current targeted therapies in the treatment of advanced colorectal cancer: A review, Therapeutic Advances in Medical Oncology, 8, (4), 2016, p276 - 293 Journal Article, 2016 DOI URL

Biniecka M, Canavan M, McGarry T, Gao W, McCormick J, Cregan S, Gallagher L, Smith T, Phelan JJ, Ryan J, O'Sullivan J, Ng CT, Veale DJ, Fearon U, Dysregulated bioenergetics: a key regulator of joint inflammation., 75, (12), 2016, p2192-2200 Journal Article, 2016 DOI

Murphy A.G, Casey R, Maguire A, Tosetto M, Butler C.T, Conroy E, Reynolds A.L, Sheahan K, O'Donoghue D, Gallagher W.M, Fennelly D, Kennedy B.N, O'Sullivan J, Preclinical validation of the small molecule drug quininib as a novel therapeutic for colorectal cancer, Scientific Reports, 6, 2016 Journal Article, 2016 DOI TARA - Full Text URL

O'Farrell N.J, Feighery R, Picardo S.L, Lynam-Lennon N, Biniecka M, McGarrigle S.A, Phelan J.J, MacCarthy F, O'Toole D, Fox E.J, Ravi N, Reynolds J.V, O'Sullivan J, Changes in mitochondrial stability during the progression of the Barrett's esophagus disease sequence, BMC Cancer, 16, (1), 2016, p497- Journal Article, 2016 TARA - Full Text DOI URL

Kavanagh ME, Conroy MJ, Clarke NE, Gilmartin NT, O'Sullivan KE, Feighery R, MacCarthy F, O'Toole D, Ravi N, Reynolds JV, O'Sullivan J, Lysaght J, Impact of the inflammatory microenvironment on T-cell phenotype in the progression from reflux oesophagitis to Barrett oesophagus and oesophageal adenocarcinoma., Cancer letters, 370, (1), 2016, p117-24 Journal Article, 2016 DOI

Phelan JJ, Feighery R, Eldin OS, Meachair SÓ, Cannon A, Byrne R, MacCarthy F, O'Toole D, Reynolds JV, O'Sullivan J, Examining the connectivity between different cellular processes in the Barrett tissue microenvironment., Cancer letters, 371, (2), 2016, p334-46 Journal Article, 2016 DOI

Dowling C, Phelan J, Cathcart M, Mehigan B, McCormick P, Dalton T, Coffey C, Newton A, O'Sullivan J and Kiely P., Protein Kinase C Beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival, Oncotarget, 7, 2016, p20919-20933 Journal Article, 2016 DOI TARA - Full Text

Phelan JJ, O'Hanlon C, Reynolds JV and O'Sullivan J, The role of energy metabolism in driving disease progression in inflammatory, hypoxic and angiogenic environments, Gastro., 1, (2), 2015, p44 - 58 Journal Article, 2015 TARA - Full Text

Palles C, Chegwidden L, Li X, Findlay JM, Farnham G, Castro Giner F, Peppelenbosch MP, Kovac M, Adams CL, Prenen H, Briggs S, Harrison R, Sanders S, MacDonald D, Haigh C, Tucker A, Love S, Nanji M, deCaestecker J, Ferry D, Rathbone B, Hapeshi J, Barr H, Moayyedi P, Watson P, Zietek B, Maroo N, Gay L, Underwood T, Boulter L, McMurtry H, Monk D, Patel P, Ragunath K, Al Dulaimi D, Murray I, Koss K, Veitch A, Trudgill N, Nwokolo C, Rembacken B, Atherfold P, Green E, Ang Y, Kuipers EJ, Chow W, Paterson S, Kadri S, Beales I, Grimley C, Mullins P, Beckett C, Farrant M, Dixon A, Kelly S, Johnson M, Wajed S, Dhar A, Sawyer E, Roylance R, Onstad L, Gammon MD, Corley DA, Shaheen NJ, Bird NC, Hardie LJ, Reid BJ, Ye W, Liu G, Romero Y, Bernstein L, Wu AH, Casson AG, Fitzgerald R, Whiteman DC, Risch HA, Levine DM, Vaughan TL, Verhaar AP, van den Brande J, Toxopeus EL, Spaander MC, Wijnhoven BP, van der Laan LJ, Krishnadath K, Wijmenga C, Trynka G, McManus R, Reynolds JV, O'Sullivan J, MacMathuna P, McGarrigle SA, Kelleher D, Vermeire S, Cleynen I, Bisschops R, Tomlinson I, Jankowski J, Polymorphisms Near TBX5 and GDF7 Are Associated With Increased Risk for Barrett's Esophagus., Gastroenterology, 148, (2), 2015, p367-78 Journal Article, 2015 DOI TARA - Full Text

El-Mashed S., O'Donovan T., Kay E., Abdallah A., Cathcart M., O'Sullivan J., O'Grady A., Reynolds J., O'Reilly S., O'Sullivan G., McKenna S., LC3B globular structures correlate with survival in esophageal adenocarcinoma, BMC Cancer, 15, (1), 2015, p582- Journal Article, 2015 TARA - Full Text DOI

Weiner-Gorzel K, Dempsey E, Milewska M, McGoldrick A, Toh V, Walsh A, Lindsay S, Gubbins L, Cannon A, Sharpe D, O'Sullivan J, Murphy M, Madden SF, Kell M, McCann A, Furlong F, Overexpression of the microRNA miR-433 promotes resistance to paclitaxel through the induction of cellular senescence in ovarian cancer cells., Cancer medicine, 4, (5), 2015, p745-58 Journal Article, 2015

Picardo SL, O'Brien MP, Feighery R, O'Toole D, Ravi N, O'Farrell NJ, O'Sullivan JN, Reynolds JV, A Barrett's esophagus registry of over 1000 patients from a specialist center highlights greater risk of progression than population-based registries and high risk of low grade dysplasia., Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus / I.S.D.E, 28, (2), 2015, p121-126 Journal Article, 2015 TARA - Full Text DOI

O'Toole A, Michielsen AJ, Nolan B, Tosetto M, Sheahan K, Mulcahy HE, Winter DC, Hyland JM, O'Connell PR, Fennelly D, O'Donoghue D, O'Sullivan J, Doherty GA, Ryan EJ, Tumour microenvironment of both early- and late-stage colorectal cancer is equally immunosuppressive., British journal of cancer, 111, (5), 2014, p927-32 Journal Article, 2014 DOI

O'Sullivan KE, Phelan JJ, O'Hanlon C, Lysaght J, O'Sullivan JN, Reynolds JV., The role of inflammation in cancer of the esophagus., Expert Reviews Gastroenterology Hepatology, 8, (7), 2014, p749 - 760 Journal Article, 2014 DOI TARA - Full Text

O'Sullivan KE, Reynolds JV, O'Hanlon C, O'Sullivan JN, Lysaght J, Could signal transducer and activator of transcription 3 be a therapeutic target in obesity-related gastrointestinal malignancy?, Journal of gastrointestinal cancer, 45, (1), 2014, p1-11 Journal Article, 2014 DOI

Lynam-Lennon N, Maher SG, Maguire A, Phelan J, Muldoon C, Reynolds JV, O'Sullivan J, Altered mitochondrial function and energy metabolism is associated with a radioresistant phenotype in oesophageal adenocarcinoma., PloS one, 9, (6), 2014, pe100738 Journal Article, 2014 TARA - Full Text DOI

Kavanagh, M.E., O'Sullivan, K.E., O'Hanlon, C., (...), Lysaght, J., Reynolds, J.V., The esophagitis to adenocarcinoma sequence; the role of inflammation, Cancer Letters, 345, (2), 2014, p182-189 Journal Article, 2014 DOI

Sheridan, J., Walsh, P., Kevans, D., (...), Mulcahy, H., Doherty, G. , Determinants of short- and long-term survival from colorectal cancer in very elderly patients, Journal of Geriatric Oncology , 5, (4), 2014, p376-83 Journal Article, 2014 TARA - Full Text DOI

Martin P, Noonan S, Mullen MP, Scaife C, Tosetto M, Nolan B, Wynne K, Hyland J, Sheahan K, Elia G, O'Donoghue D, Fennelly D, O'Sullivan J, Predicting response to vascular endothelial growth factor inhibitor and chemotherapy in metastatic colorectal cancer., BMC cancer, 14, 2014, p887 Journal Article, 2014 DOI TARA - Full Text

Phelan JJ, MacCarthy F, Feighery R, O'Farrell NJ, Lynam-Lennon N, Doyle B, O'Toole D, Ravi N, Reynolds JV, O'Sullivan J, Differential expression of mitochondrial energy metabolism profiles across the metaplasia-dysplasia-adenocarcinoma disease sequence in Barrett's oesophagus., Cancer letters, 354, (1), 2014, p122-31 Journal Article, 2014 TARA - Full Text DOI

Lynam-Lennon N, Connaughton R, Carr E, Mongan AM, O'Farrell NJ, Porter RK, Brennan L, Pidgeon GP, Lysaght J, Reynolds JV, O'Sullivan J, Excess visceral adiposity induces alterations in mitochondrial function and energy metabolism in esophageal adenocarcinoma., BMC cancer, 14, 2014, p907 Journal Article, 2014 DOI TARA - Full Text

Sheridan, J. Tosetto, M. Gorman, J. O'Donoghue, D. Sheahan, K. Hyland, J. Mulcahy, H. Gibbons, D. O'Sullivan, J., Effects of radiation on levels of DNA damage in normal non-adjacent mucosa from colorectal cancer cases, Journal of Gastrointestinal Cancer, 44, (1), 2013, p41 - 45 Journal Article, 2013 URL DOI

Doyle, B., Hagan, S., Al-Mulla, F., (...), O'Sullivan, J., Kolch, W. , Raf kinase inhibitor protein expression combined with peritoneal involvement and lymphovascular invasion predicts prognosis in Dukes' B colorectal cancer patients , Histopathology , 62, (3), 2013, p505-510 Journal Article, 2013 URL

Guinan, EM, Hussey, J, McGarrigle, SA, Healy, LA, O'Sullivan, JN, Bennett, K, Connolly, EM, A prospective investigation of predictive and modifiable risk factors for breast cancer in unaffected BRCA1 and BRCA2 gene carriers, BMC CANCER, 13, 2013, p138- Journal Article, 2013 DOI TARA - Full Text

Hu, J, Locasale, JW, Bielas, JH, O'Sullivan, J, Sheahan, K, Cantley, LC, Vander Heiden, MG, Vitkup, D, Heterogeneity of tumor-induced gene expression changes in the human metabolic network, NATURE BIOTECHNOLOGY, 31, (6), 2013, p522-U11 Journal Article, 2013 DOI

Michielsen, AJ, Noonan, S, Martin, P, Tosetto, M, Marry, J, Biniecka, M, Maguire, AA, Hyland, JM, Sheahan, KD, O'Donoghue, DP, Mulcahy, HE, Fennelly, D, Ryan, EJ, O'Sullivan, JN, Inhibition of Dendritic Cell Maturation by the Tumor Microenvironment Correlates with the Survival of Colorectal Cancer Patients following Bevacizumab Treatment, MOLECULAR CANCER THERAPEUTICS, 11, (8), 2012, p1829-1837 Journal Article, 2012 DOI

Kevans D, Gorman S, Tosetto M, Sheahan K, O'Donoghue D, Mulcahy H and O'Sullivan J. , Clusterin and chemotherapy sensitivity under normoxic graded hypoxic conditions in colorectal cancer , Journal of Gastrointestinal Cancer , 43, (2), 2012, p305-313 Journal Article, 2012 DOI

Picardo SL, Maher SG, O'Sullivan JN, Reynolds JV, Barrett's to oesophageal cancer sequence: a model of inflammatory-driven upper gastrointestinal cancer., Digestive surgery, 29, (3), 2012, p251-60 Journal Article, 2012 DOI

Michielsen AJ, Ryan EJ, O'Sullivan JN, Dendritic cell inhibition correlates with survival of colorectal cancer patients on bevacizumab treatment., Oncoimmunology, 1, (8), 2012, p1445-1447 Journal Article, 2012 DOI URL TARA - Full Text

Canney, AL, Kevans, D, Wang, LM, Hyland, JMP, Mulcahy, HE, O'Donoghue, DP, O'Sullivan, J, Geraghty, R, Sheahan, K, Stage II colonic adenocarcinoma: a detailed study of pT4N0 with emphasis on peritoneal involvement and the role of tumour budding, HISTOPATHOLOGY, 61, (3), 2012, p488-496 Journal Article, 2012 DOI

Mary-Clare Cathcart, Kenneth J. O'Byrne, John V. Reynolds, Jacintha O' Sullivan, Graham P. Pidgeon, COX-Derived prostanoid pathways in gastrointestinal cancer development and progression: Novel targets for prevention and intervention, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1825, (1), 2012, p49-63 Journal Article, 2012 TARA - Full Text

Ericson, NG, Kulawiec, M, Vermulst, M, Sheahan, K, O'Sullivan, J, Salk, JJ, Bielas, JH, Decreased Mitochondrial DNA Mutagenesis in Human Colorectal Cancer, PLOS GENETICS, 8, (6), 2012, pe1002689- Journal Article, 2012 DOI TARA - Full Text

Leonard C Harty, Monika Biniecka, Jacintha O'Sullivan, Edward Fox, Kevin Mulhall, Douglas J Veale, Ursula Fearon, Mitochondrial mutagenesis correlates with the local inflammatory environment in arthritis, Annals of the Rheumatic Diseases: The EULAR Journal, 71, (4), 2012, p582-588 Journal Article, 2012 DOI TARA - Full Text

Biniecka, M., Fox, E., Gao, W., (...), Fearon, U., O'Sullivan, J., Hypoxia induces mitochondrial mutagenesis and dysfunction in inflammatory arthritis, Arthritis and Rheumatism, 63, (8), 2011, p2172-2182 Journal Article, 2011

Kennedy RD, Bylesjo M, Kerr P, Davison T, Black JM, Kay EW, Holt RJ, Proutski V, Ahdesmaki M, Farztdinov V, Goffard N, Hey P, McDyer F, Mulligan K, Mussen J, O'Brien E, Oliver G, Walker SM, Mulligan JM, Wilson C, Winter A, O'Donoghue D, Mulcahy H, O'Sullivan J, Sheahan K, Hyland J, Dhir R, Bathe OF, Winqvist O, Manne U, Shanmugam C, Ramaswamy S, Leon EJ, Smith WI, McDermott U, Wilson RH, Longley D, Marshall J, Cummins R, Sargent DJ, Johnston PG, Harkin DP, Development and independent validation of a prognostic assay for stage II colon cancer using formalin-fixed paraffin-embedded tissue., Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 29, (35), 2011, p4620-6 Journal Article, 2011 DOI

Michielsen, AJ, Hogan, AE, Marry, J, Tosetto, M, Cox, F, Hyland, JM, Sheahan, KD, O'Donoghue, DP, Mulcahy, HE, Ryan, EJ, O'Sullivan, JN, Tumour Tissue Microenvironment Can Inhibit Dendritic Cell Maturation in Colorectal Cancer, PLOS ONE, 6, (11), 2011, pe27944- Journal Article, 2011 TARA - Full Text DOI

Sapetto-Rebow, B., McLoughlin, S.C., O'Shea, L.C., (...), Hensey, C., Kennedy, B.N. , Maternal topoisomerase II alpha, not topoisomerase II beta, enables embryonic development of zebrafish top2a -/- mutants, BMC Developmental Biology , 11, 2011, p71- Journal Article, 2011 DOI TARA - Full Text

Biniecka M, Fox E, Gao W, Ng CT, Veale DJ, Fearon U, O'Sullivan J, Hypoxia induces mitochondrial mutagenesis and dysfunction in inflammatory arthritis., Arthritis and rheumatism, 63, (8), 2011, p2172-82 Journal Article, 2011

Kevans, D, Wang, LM, Sheahan, K, Hyland, J, O'Donoghue, D, Mulcahy, H, O'Sullivan, J, Epithelial-Mesenchymal Transition (EMT) Protein Expression in a Cohort of Stage II Colorectal Cancer Patients With Characterized Tumor Budding and Mismatch Repair Protein Status, INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, 19, (6), 2011, p751-760 Journal Article, 2011 DOI

Kennedy, A., Teck Ng, C., Cheng Chang, T., (...), Fearon, U., Veale, D.J., Tumor necrosis factor blocking therapy alters joint inflammation and hypoxia, Arthritis and Rheumatism, 63, (4), 2011, p923-932 Journal Article, 2011 DOI

Biniecka M, Kennedy A, Ng CT, Chang TC, Balogh E, Fox E, Veale DJ, Fearon U, O'Sullivan JN., Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxiainduced mitochondrial mutagenesis in inflammatory arthritis, Arthritis Research & Therapy , 13, (4), 2011, pR121 Journal Article, 2011 URL DOI TARA - Full Text

Doherty G, Walsh P, Sheridan J, Kevans D, Keegan D, Nolan B, White A, McDermott E, Sheahan K, O'Shea D, Hyland J, O'Donoghue D, O'Sullivan J and Mulchay H. , Clinical and Pathological Factors associated with colorectal cancer at the Upper extreme of life, Journal of the American Geriatrics Society, 58, (4), 2010 Journal Article, 2010

Gorman S, Fox E, O'Donoghue D, Sheahan K, Hyland J, Mulcahy H, Loeb L and O'Sullivan J., Mitochondrial mutagenesis induced by tumour specific radiation bystander effects , Journal of Molecular Medicine, 88, (7), 2010, p701 - 8 Journal Article, 2010

Biniecka M, Kennedy A, T Ng C, Fearon U, Douglas J Veale, O'Sullivan J. , Oxidative damage in synovial tissue is associated with in vivo hypoxic status in the arthritic joint, Annals of the Rheumatic Diseases, 69, (6), 2010 Journal Article, 2010

Byrne A, Foran E, Sharma R, Davis A, Mahon C, O'Sullivan J, O'Donoghue D, Kelleher D, Long A. , Opposing effects of Deoxycholic and Ursodeoxycholic acid on Golgi Structure: implications for colon cancer progression., Carcinogenesis, 31, (4), 2010, p737-44 Journal Article, 2010

Bronner M, Skacel M, Crispin D, Hoff P, Emond M, Lai L, Tubbs R, O'Sullivan J, Rabinovitch P and Brentnall T., Array-based comparative genomic hybridization in ulcerative colitis neoplasia: single non dysplastic biopsies distinguish progressors from non progressors, Modern Pathology, 23, (12), 2010 Journal Article, 2010

Young O, Crotty T, O'Connell R, O'Sullivan J and Curran A. , Levels of oxidative damage and lipid peroxidation in thyroid neoplasia. , Head Neck, 32, (6), 2010, p750-756 Journal Article, 2010

Watson J, Watson C, McCrohan A, Woodfine K, Tosetto M, McDaid J, Gallagher E, Betts D, Baugh J, O'Sullivan J, Murrell A, Watson W and McCann A. , Generation of an epigenetic signature by chronic hypoxia in prostate cells., Hum Mol Genet., 1;18, (19), 2009, p3594-604. Journal Article, 2009

Gorman S, Tosetto M, Lyng F, Howe O, Sheahan K, O'Donoghue D, Hyland J, Mulcahy H and O'Sullivan J. , Radiation and chemotherapy bystander effects induce early genomic instability events: telomere shortening and bridge formation coupled with mitochondrial dysfunction. , Mutat Res. , 2, (669), 2009, p1-2 Journal Article, 2009

Wang L, Kevans D, Mulcahy H, O'Sullivan J, Hyland J, O'Donoghue D and Sheahan K. , Tumour budding is a strong and reproducible prognostic marker in T3N0 colorectal cancer. , The American Journal of Surgical Pathology, 33, (1), 2009, p134-141 Journal Article, 2009

Coss A, Tosetto M, Fox E, Sapetto-Rebow B, Gorman S, Kennedy B, Lloyd, Hyland J, O'Donoghue D, Sheahan K, Leahy D, Mulcahy H, O'Sullivan J. , Increased Topoisomerase IIα Expression in Colorectal Cancer is Associated with Pathologically Aggressive Disease and Leads to Chemotherapy Resistance via Inhibition of Apoptosis. , Cancer Lett., 276, (2), 2009, p228-238 Journal Article, 2009

Sheridan J, Wang L, Tosetto M, Dave Kevans, Hyland J, Sheahan K, O'Donoghue D, Mulcahy H & O'Sullivan J. , High levels of 8-Hydroxyguanine, a marker of oxidative DNA Damage predicts overall survival in sporadic colorectal cancer, Br J Cancer., 100, (2), 2009, p381-388. Journal Article, 2009

Sullivan S, Tosetto M, Kevans D, Coss A, Wang L, O'Donoghue D, Hyland J, Fennelly D, Sheahan K, Mulcahy H & O'Sullivan J. , Localization of a nuclear Cathepsin L and its association with disease progression and poor outcome in colorectal cancer. , Int J Cancer, 1;125, (1), 2009, p54-61 Journal Article, 2009

Howe O, O' Sullivan J, Nolan B, Vaughan J, Clarke C, Gorman S, McClean B, Lyng F, Do radiation-induced bystander effects correlate to the intrinsic radiosensitivity of individuals and have clinical significance? , Radiation Research, 171, 2009, p521-529. Journal Article, 2009

Prencipe M, Fitzpatrick P, Gorman S, Tosetto M, Furlong F, Harrison M, O'Sullivan J, McCann A. , Cellular senescence induced by abberant MAD2 levels impacts on paclitaxel responsiveness in vitro. , Br J Cancer. , 1:101, (11), 2009, p1900-8 Journal Article, 2009

Kevans D, Foley J, Tenniswood M, Sheahan K, Hyland J, O'Donoghue D, Mulchay H and O'Sullivan J. , High clusterin expression correlates with a poor outcome in Stage II T3NO colorectal cancer. , Cancer Epidemiology Biomarkers and Prevention, 18, (2), 2009, p393-399 Journal Article, 2009

Bronner MP, O'Sullivan JN, Rabinovitch PS, Crispin DA, Chen L, Emond MJ, Rubin CE, Brentnall TA, Genomic biomarkers to improve ulcerative colitis neoplasia surveillance., The American journal of pathology, 173, (6), 2008, p1853-60 Journal Article, 2008

O'Sullivan J, Sheridan J, Mulcahy H, Tenniswood M, Morrissey C, The effect of green tea on oxidative damage and tumour formation in Lobund-Wistar rats., European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 17, (6), 2008, p489-501 Journal Article, 2008

Lynch, L, O'Donoghue, D, Dean, J, O'Sullivan, J, O'Farrelly, C, Golden-Mason, L, Detection and characterization of hemopoietic stem cells in the adult human small intestine., Journal of immunology (Baltimore, Md. : 1950), 176, (9), 2006, p5199-204 Journal Article, 2006 URL

O'Sullivan J, Risques RA, Mandelson MT, Chen L, Brentnall TA, Bronner MP, Macmillan MP, Feng Z, Siebert JR, Potter JD, Rabinovitch PS, Telomere length in the colon declines with age: a relation to colorectal cancer?, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 15, (3), 2006, p573-7 Journal Article, 2006

O'Sullivan JN, Finley JC, Risques RA, Shen WT, Gollahon KA, Rabinovitch PS, Quantitative fluorescence in situ hybridization (QFISH) of telomere lengths in tissue and cells., Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.], Chapter 12, 2005, pUnit 12.6 Journal Article, 2005

O'Sullivan JN, Finley JC, Risques RA, Shen WT, Gollahon KA, Moskovitz AH, Gryaznov S, Harley CB, Rabinovitch PS, Telomere length assessment in tissue sections by quantitative FISH: image analysis algorithms., Cytometry. Part A : the journal of the International Society for Analytical Cytology, 58, (2), 2004, p120-31 Journal Article, 2004

Zierau O, O'Sullivan J, Morrissey C, McDonald D, Wünsche W, Schneider MR, Tenniswood MP, Vollmer G, Tamoxifen exerts agonistic effects on clusterin and complement C3 gene expression in RUCA-I primary xenografts and metastases but not normal uterus., Endocrine-related cancer, 11, (4), 2004, p823-30 Journal Article, 2004

O'Sullivan J, Whyte L, Drake J, Tenniswood M, Alterations in the post-translational modification and intracellular trafficking of clusterin in MCF-7 cells during apoptosis., Cell death and differentiation, 10, (8), 2003, p914-27 Journal Article, 2003

O'Sullivan JN, Bronner MP, Brentnall TA, Finley JC, Shen WT, Emerson S, Emond MJ, Gollahon KA, Moskovitz AH, Crispin DA, Potter JD, Rabinovitch PS, Chromosomal instability in ulcerative colitis is related to telomere shortening., Nature genetics, 32, (2), 2002, p280-4 Journal Article, 2002

Morrissey C, Buser A, Scolaro J, O'Sullivan J, Moquin A, Tenniswood M, Changes in hormone sensitivity in the ventral prostate of aging Sprague-Dawley rats., Journal of andrology, 23, (3), 2002, p341-51 Journal Article, 2002

Lakins J, Bennett SA, Chen JH, Arnold JM, Morrissey C, Wong P, O'Sullivan J, Tenniswood M, Clusterin biogenesis is altered during apoptosis in the regressing rat ventral prostate., The Journal of biological chemistry, 273, (43), 1998, p27887-95 Journal Article, 1998

Tenniswood M, Wang Z, Lakins J, Morrissey C, O'Sullivan J, Tang H, Clusterin in the male reproductive tract., Journal of andrology, 19, (5), 1998, p508-16 Journal Article, 1998

Non-Peer-Reviewed Publications

Alina Qaisar, Jacintha O'Sullivan, Niamh M. O'Boyle, P22: Synthesis and Physicochemical Properties of Amino Acid Prodrugs of the Radiosensitser Pyrazinib, 30th Annual GP2A Medicinal Chemistry Conference, Dublin, 24-26 August 2022, 2022 Poster, 2022