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Dr. Niamh Lynam-Lennon
Research Assistant Professor, Surgery

Publications and Further Research Outputs

Peer-Reviewed Publications

O'Brien R.M., Lynam-Lennon N., Olcina M.M., Thinking inside the box: intracellular roles for complement system proteins come into focus, British Journal of Cancer, 128, (2), 2023, p165 - 167, p165-167 Journal Article, 2023 DOI

Townsend L, Dyer AH, Naughton A, Imangaliyev S, Dunne J, Kiersey R, Holden D, Mooney A, Leavy D, Ridge K, Sugrue J, Aldoseri M, Kelliher JH, Ní Cheallaigh C, Severe COVID-19 is characterised by inflammation and immature myeloid cells early in disease progression, Heliyon, 8, (4), 2022, pe09230 - e09236 Journal Article, 2022

Donlon NE, Davern M, O'Connell F, Sheppard A, Heeran A, Bhardwaj A, Butler C, Narayanasamy R, Donohoe C, Phelan JJ, Lynam-Lennon N, Dunne MR, Maher S, O'Sullivan J, Reynolds JV, Lysaght J., Impact of radiotherapy on the immune landscape in oesophageal adenocarcinoma, World Journal of Gastroenterology, 2022 Journal Article, 2022

Kennedy S.P., Treacy O., Allott E.H., Eustace A.J., Lynam-Lennon N., Buckley N., Robson T., Precision Medicine and Novel Therapeutic Strategies in Detection and Treatment of Cancer: Highlights from the 58th IACR Annual Conference, Cancers, 14, (24), 2022 Journal Article, 2022 DOI

Davern M, Fitzgerald MC, Buckley CE, Heeran AB, Donlon NE, McGrath J, O'Connell F, Deshpande MR, Hayes C, MacDonald J, Sheppard AD, Reynolds JV, Maher SG, Lynam-Lennon N, Murphy B, Lysaght J, PD-1 and TIGIT blockade differentially affect tumour cell survival under hypoxia and glucose deprived conditions in oesophageal adenocarcinoma; implications for overcoming resistance to PD-1 blockade in hypoxic tumours, Cancer Letters, 2022 Journal Article, 2022

Waszczuk-Gajda A., Penack O., Sbianchi G., Koster L., Blaise D., Remenyi P., Russell N., Ljungman P., Trneny M., Mayer J., Iacobelli S., Kobbe G., Scheid C., Apperley J., Touzeau C., Lenhoff S., Jantunen E., Anagnostopoulos A., Paris L., Browne P., Thieblemont C., Schaap N., Sierra J., Yakoub-Agha I., Garderet L., Styczynski J., Schoemans H., Moiseev I., Duarte R.F., Peric Z., Montoto S., van Biezen A., Mikulska M., Aljurf M., Ruutu T., Kroger N., Morris C., Koenecke C., Schoenland S., Basak G.W., Complications of Autologous Stem Cell Transplantation in Multiple Myeloma: Results from the CALM Study, Journal of Clinical Medicine, 11, (12), 2022 Journal Article, 2022 DOI

Masouridi-Levrat S, Olavarria E, Iacobelli S, Aljurf M, Morozova E, Niittyvuopio R, Sengeloev H, Reményi P, Helbig G, Browne P, Ganser A, Nagler A, Snowden JA, Robin M, Passweg J, Van Gorkom G, Wallet HL, Hoek J, Blok HJ, De Witte T, Kroeger N, Hayden P, Chalandon Y, Agha IY., Outcomes and toxicity of allogeneic hematopoietic cell transplantation in chronic myeloid leukemia patients previously treated with second-generation tyrosine kinase inhibitors: a prospective non-interventional study from the Chronic Malignancy Working Party of the EBMT., Bone marrow transplantation, 57, (1), 2022, p23-30 Journal Article, 2022 DOI

Aoife Branagan, Caoimhe S. Costigan, Maria Stack, Cara Slagle, Eleanor J. Molloy, Management of Acute Kidney Injury in Extremely Low Birth Weight Infants, Frontiers in Pediatrics , 2022 Journal Article, 2022 DOI

Branagan A., Yu I., Gurusamy K., Miletin J., Thresholds for surfactant use in preterm neonates: a network meta-analysis, Archives of Disease in Childhood: Fetal and Neonatal Edition, 2022 Journal Article, 2022 DOI

Rebecca Amet, Viola Previtali, Helene B. Mihigo, Emily Sheridan, Sarah Brophy , Nadhim Kamil Hante, Maria Jose Santos-Martinez, Patrick J. Hayden, Paul V. Browne, Isabel Rozas, Anthony M. McElligott , Daniela M. Zisterer , A novel aryl-guanidinium derivative, VP79s, targets the signal transducer and activator of transcription 3 signaling pathway, downregulates myeloid cell leukaemia-1 and exhibits preclinical activity against multiple myeloma , Life Sciences, 290, 2022 Journal Article, 2022 DOI TARA - Full Text

Davern M, O' Brien RM, McGrath J, Donlon NE, Melo AM, Buckley CE, Sheppard AD, Reynolds JV, Lynam-Lennon N, Maher SG, Lysaght J., PD-1 blockade enhances chemotherapy toxicity in oesophageal adenocarcinoma., Scientific Reports, 12, (1), 2022, p3259- Journal Article, 2022

Aoife Branagan, Niofa Canty, Evanne O'Halloran, Marian Madden, Michael Brendan O'Neill, Evaluation of the Quick Wee method of inducing faster clean catch urine collection in pre-continent infants: a randomized controlled trial, World Journal of Pediatrics , 2022 Journal Article, 2022 DOI

Abend N., Adams E., Al Balushi A., Alburaki W., Appendino J., Barbosa V.S., Birca A., Bonifacio S., Branagan A., Chang T., Chowdhury R., Christou H., Chu C., Cilio M.R., Comani S., Corsi-Cabrera M., Croce P., Cubero-Rego L., Dawoud F., de Vries L., Dehaes M., Devane D., Duncan A., El Ters N., El-Dib M., Elshibiny H., Esser M., Fairchild K., Finucane E., Franceschini M.A., Gallagher A., Ghosh A., Glass H., Venkata S.K.R.G., Baillet T.H., Herzberg E., Hildrey E., Hurley T., Inder T., Jacobs E., Jefferies K., Jermendy A., Khazaei M., Kilmartin K., King G., Lauronen L., Lee S., Leijser L., Lind J., Llaguno N.S., Machie M., Magalhaes M., Mahdi Z., Maluomi J., Marandyuk B., Massey S., McCulloch C., Metsaranta M., Mikkonen K., Mohammad K., Molloy E., Momin S., Munster C., Murthy P., Netto A., Nevalainen P., Nguyen J., Nieves M., Nyman J., Oliver N., Peeters C., Pietrobom R.F.R., Pijpers J., Pinchefksy E., Ping Y.B., Quirke F., Raeisi K., Ricardo-Garcell J., Robinson J., Rodrigues D.P., Rosati J., Scott J., Scringer-Wilkes M., Shellhaas R., Smit L., Soul J., Srivastava A., Steggerda S., Sunwoo J., Szakmar E., Tamburro G., Thomas S., Toiviainen-Salo S., Toma A.I., Vanhatalo S., Variane G.F.T., Vein A., Vesoulis Z., Vilan A., Volpe J., Weeke L., Wintermark P., Wusthoff C., Zappasodi F., Zein H., Zempel J., Proceedings of the 13th International Newborn Brain Conference: Neonatal Neurocritical Care, Seizures, and Continuous EEG monitoring, Journal of neonatal-perinatal medicine, 15, (2), 2022, p467 - 485, p467-485 Journal Article, 2022 DOI

Molloy E.J., El-Dib M., Juul S.E., Benders M., Gonzalez F., Bearer C., Wu Y.W., Robertson N.J., Hurley T., Branagan A., Michael Cotten C., Tan S., Laptook A., Austin T., Mohammad K., Rogers E., Luyt K., Bonifacio S., Soul J.S., Gunn A.J., Bonifacio S., Wintermark P., Aly H., Chang T., Chau V., Glass H., Lemmon M., Massaro A., Wusthoff C., deVeber G., Pardo A., McCaul M.C., Neuroprotective therapies in the NICU in term infants: present and future, Pediatric Research, 2022 Journal Article, 2022 DOI

O'Gorman P, Laubach JP, O'Dwyer ME, Krawczyk J, Yee AJ, Gilligan O, Cahill MR, Rosenblatt J, Quinn J, Murphy PT, DiPietro H, Perera MR, Crotty GM, Cummings K, Hayden PJ, Browne P, Savell A, O'Leary HM, O'Keeffe D, Masone K, Hennessy BJ, Guerrero Garcia T, Scott K, Saeed K, Bianchi G, Dowling P, Tierney C, Richardson PG., Phase 2 studies of lenalidomide, subcutaneous bortezomib, and dexamethasone as induction therapy in patients with newly diagnosed multiple myeloma., American journal of hematology, 97, (5), 2022, p562-573 Journal Article, 2022 DOI

Lawless S., Sbianchi G., Morris C., Iacobelli S., Bosman P., Blaise D., Remenyi P., Byrne J.L., Mayer J., Apperley J., Lund J., Kobbe G., Schaap N., Isaksson C., Lenhoff S., Basak G., Touzeau C., Wilson K.M.O., Gonzalez Muniz S., Scheid C., Browne P., Anagnostopoulos A., Rambaldi A., Jantunen E., Kroger N., Schonland S., Yakoub-Agha I., Garderet L., IgD Subtype But Not IgM or Non-Secretory Is a Prognostic Marker for Poor Survival Following Autologous Hematopoietic Cell Transplantation in Multiple Myeloma. Results From the EBMT CALM (Collaboration to Collect Autologous Transplant Outcomes in Lymphomas and Myeloma) Study, Clinical Lymphoma, Myeloma and Leukemia, 21, (10), 2021, p686 - 693, p686-693 Journal Article, 2021 DOI

Domingo-Domenech E., Duarte R.F., Boumedil A., Onida F., Gabriel I., Finel H., Arcese W., Browne P., Beelen D., Kobbe G., Veelken H., Arranz R., Greinix H., Lenhoff S., Poire X., Ribera J.M., Thompson J., Zuckerman T., Mufti G.J., Cortelezzi A., Olavarria E., Dreger P., Sureda A., Montoto S., Allogeneic hematopoietic stem cell transplantation for advanced mycosis fungoides and Sézary syndrome. An updated experience of the Lymphoma Working Party of the European Society for Blood and Marrow Transplantation, Bone Marrow Transplantation, 56, (6), 2021, p1391 - 1401, p1391-1401 Journal Article, 2021 DOI

Buckley AM, Dunne MR, Lynam-Lennon N, Kennedy SA, Cannon A, Reynolds AL, Maher SG, Reynolds JV, Kennedy BN, O'Sullivan J., Pyrazinib (P3), [(E)-2-(2-Pyrazin-2-yl-vinyl)-phenol], a small molecule pyrazine compound enhances radiosensitivity in oesophageal adenocarcinoma., Cancer letters, 447, 2019, p115-129 Journal Article, 2019 DOI

Mongan AM, Lynam-Lennon N, Doyle SL, Casey R, Carr E, Cannon A, Conroy MJ, Pidgeon GP, Brennan L, Lysaght J, Reynolds JV, O'Sullivan J., Visceral Adipose Tissue Modulates Radiosensitivity in Oesophageal Adenocarcinoma., International journal of medical sciences, 16, (4), 2019, p519-528 Journal Article, 2019 TARA - Full Text DOI

Treston B.P., Semberova J., Kernan R., Crothers E., Branagan A., O'Cathain N., Miletin J., Assessment of neonatal heart rate immediately after birth using digital stethoscope, handheld ultrasound and electrocardiography: An observational cohort study, Archives of Disease in Childhood: Fetal and Neonatal Edition, 104, (2), 2019, pF227- Journal Article, 2019 DOI

Buckley AM, Lynam-Lennon N, Kennedy SA, Dunne MR, Aird JJ, Foley EK, Clarke N, Ravi N, O'Toole D, Reynolds JV, Kennedy BN, O'Sullivan J., Leukaemia inhibitory factor is associated with treatment resistance in oesophageal adenocarcinoma., Oncotarget, 9, (72), 2018, p33634-33647 Journal Article, 2018 TARA - Full Text DOI

Matchett K.B, Lynam-Lennon N, William Watson R, Brown J.A.L, Advances in precision medicine: Tailoring individualized therapies, Cancers, 9, (11), 2017, p146 Journal Article, 2017 URL DOI

Lynam-Lennon N, Heavey S, Sommerville G, Bibby BA, Ffrench B, Quinn J, Gasch C, O'Leary JJ, Gallagher MF, Reynolds JV, Maher SG, MicroRNA-17 is downregulated in esophageal adenocarcinoma cancer stem-like cells and promotes a radioresistant phenotype, Oncotarget, 8, (7), 2017, p11400 - 11413 Journal Article, 2017 TARA - Full Text DOI

Brown J.A.L, Chonghaile T.N, Matchett K.B, Lynam-Lennon N, Kiely P.A, Big data-led cancer research, application, and insights, Cancer Research, 76, (21), 2016, p6167 - 6170 Journal Article, 2016 URL DOI

McDermott N., Meunier A., Mooney B., Nortey G., Hernandez C., Hurley S., Hurley S., Lynam-Lennon N., Barsoom S., Bowman K., Marples B., Jones G., Marignol L., Fractionated radiation exposure amplifies the radioresistant nature of prostate cancer cells, Scientific Reports, 6, 2016 Journal Article, 2016 DOI

Lynam-Lennon N., Bibby B., Mongan A., Marignol L., Paxton C., Geiersbach K., Geiersbach K., Bronner M., Bronner M., O"Sullivan J., Reynolds J., Maher S., Maher S., Low MiR-187 expression promotes resistance to chemoradiation therapy in vitro and correlates with treatment failure in patients with esophageal adenocarcinoma, Molecular Medicine, 22, 2016, p388-397 Journal Article, 2016 DOI

O'Farrell N.J, Feighery R, Picardo S.L, Lynam-Lennon N, Biniecka M, McGarrigle S.A, Phelan J.J, MacCarthy F, O'Toole D, Fox E.J, Ravi N, Reynolds J.V, O'Sullivan J, Changes in mitochondrial stability during the progression of the Barrett's esophagus disease sequence, BMC Cancer, 16, (1), 2016, p497- Journal Article, 2016 TARA - Full Text DOI URL

Mongan AM, Lynam-Lennon N, Casey R, Maher S, Pidgeon G, Reynolds JV, O'Sullivan J, Visceral obesity stimulates anaphase bridge formation and spindle assembly checkpoint dysregulation in radioresistant oesophageal adenocarcinoma., Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2015 Journal Article, 2015

Mongan, A.M., Lynam-Lennon, N., Casey, R., Maher, S., Pidgeon, G., Reynolds, J.V., O"Sullivan, J., Erratum to: Visceral obesity stimulates anaphase bridge formation and spindle assembly checkpoint dysregulation in radioresistant oesophageal adenocarcinoma, Clinical and Translational Oncology, 2015 Journal Article, 2015

Phelan JJ, MacCarthy F, Feighery R, O'Farrell NJ, Lynam-Lennon N, Doyle B, O'Toole D, Ravi N, Reynolds JV, O'Sullivan J, Differential expression of mitochondrial energy metabolism profiles across the metaplasia-dysplasia-adenocarcinoma disease sequence in Barrett's oesophagus., Cancer letters, 354, (1), 2014, p122-31 Journal Article, 2014 TARA - Full Text DOI

Lynam-Lennon N, Maher SG, Maguire A, Phelan J, Muldoon C, Reynolds JV, O'Sullivan J, Altered mitochondrial function and energy metabolism is associated with a radioresistant phenotype in oesophageal adenocarcinoma., PloS one, 9, (6), 2014, pe100738 Journal Article, 2014 TARA - Full Text DOI

Lynam-Lennon, N., Maher, S.G., Maguire, A., (...), Reynolds, J.V., O'Sullivan, J., Altered mitochondrial function and energy metabolism is associated with a radioresistant phenotype in oesophageal adenocarcinoma, PLoS ONE , 9, (6), 2014, pe100738- Journal Article, 2014 TARA - Full Text DOI

Lynam-Lennon N, Connaughton R, Carr E, Mongan AM, O'Farrell NJ, Porter RK, Brennan L, Pidgeon GP, Lysaght J, Reynolds JV, O'Sullivan J., Excess visceral adiposity induces alterations in mitochondrial function and energy metabolism in esophageal adenocarcinoma., BMC Cancer, 3, (14), 2014, p907- Journal Article, 2014 TARA - Full Text

Lynam-Lennon N, Connaughton R, Carr E, Mongan AM, O'Farrell NJ, Porter RK, Brennan L, Pidgeon GP, Lysaght J, Reynolds JV, O'Sullivan J, Excess visceral adiposity induces alterations in mitochondrial function and energy metabolism in esophageal adenocarcinoma., BMC cancer, 14, 2014, p907 Journal Article, 2014 DOI TARA - Full Text

Casey JP, McGettigan P, Lynam-Lennon N, McDermott M, Regan R, Conroy J, Bourke B, O'Sullivan J, Crushell E, Lynch S, Ennis S, Identification of a mutation in LARS as a novel cause of infantile hepatopathy., Molecular genetics and metabolism, 106, (3), 2012, p351-8 Journal Article, 2012 DOI

MicroRNA in Oncogenesis in, editor(s)Trygve Tollefsbo , Epigenetics in Human Disease, Elsevier, 2012, pp89 - 110, [Lynam-Lennon N, Gray SG and Maher SG] Book Chapter, 2012

Lynam-Lennon N, Reynolds JV, Marignol L, Sheils OM, Pidgeon GP, Maher SG, MicroRNA-31 modulates tumour sensitivity to radiation in oesophageal adenocarcinoma., Journal of molecular medicine (Berlin, Germany), 2012 Journal Article, 2012 DOI

Hötte GJ, Linam-Lennon N, Reynolds JV, Maher SG, Radiation sensitivity of esophageal adenocarcinoma: the contribution of the RNA-binding protein RNPC1 and p21-mediated cell cycle arrest to radioresistance., Radiation research, 177, (3), 2012, p272-9 Journal Article, 2012 DOI

Lynam-Lennon N, Reynolds JV, Pidgeon GP, Lysaght J, Marignol L, Maher SG, Alterations in DNA repair efficiency are involved in the radioresistance of esophageal adenocarcinoma., Radiation research, 174, (6), 2010, p703 - 711 Journal Article, 2010 DOI

Lynam-Lennon N, Maher SG, Reynolds JV, The roles of microRNA in cancer and apoptosis., Biological reviews of the Cambridge Philosophical Society, 84, (1), 2009, p55-71 Journal Article, 2009

Non-Peer-Reviewed Publications

A Branagan, L Perrem, J Semberova, A O'Sullivan, J Miletin, A Doolan, Central catheter removal timing and growth patterns in preterm infants, European Journal of Clinical Nutrition , 2020 Journal Article, 2020 DOI