Dr. Sarah McGarrigle
Dr. Sarah McGarrigle graduated with a BSc (hons.)in Biochemistry from University College Dublin in 2003. She completed her PhD in the Royal College of Surgeons in 2007 which focused on investigating the role of homocysteine and its thiolactone derivative in promoting platelet activation and thrombosis. She joined the Dept. of Surgery, Trinity College Dublin in 2009 as the upper gastrointestinal biobank manager. In 2011 she joined the laboratory of Prof. Elizabeth Connolly to establish and co-ordinate the departmental breast Cancer Research Program. In addition to her role as a researcher, she actively lectures on the MSc in Translational Oncology and BSc in molecular Medicine courses in Trinity College Dublin.
Our group’s major research interest involves investigating the role of lifestyle factors including obesity and its associated metabolic syndrome in breast cancer initiation and progression. A major focus of our group is investigating the potential to reduce breast cancer risk in women with a germline BRCA 1/2 mutation. To this end we are conducting a prospective study to investigate predictive and modifiable risk factors for the development of breast cancer in a cohort of BRCA mutation carriers. This project will also examine the effect of these lifestyle factors surrogate markers of cancer risk including telomere length and oxidative stress in this patient cohort. In addition we are currently investigating the molecular events involved in driving the development and progression of sporadic breast cancer in the context of obesity and the metabolic syndrome. Of particular interest is the role of mammary adipose tissue in this disease. This project will also examine how obesity and the metabolic syndrome affect this adipose tissue depot. Central to our research, we maintain a breast cancer blood and tissue biobank of high quality samples linked to up to date clinical information. This biobank provides us with the patient material necessary to meet our research objectives.
- Influence of modifiable lifestyle factors on breast cancer risk in BRCA mutation carriers.
- Role of mammary adipose tissue in driving breast tumour progression.
- PIK3CA mutations in obesity associated breast cancer (collaboration with Prof. Bryan Hennessy & Dr. Sinead Toomey).
- Role of vitamin D in obesity associated breast cancer (collaboration with Prof. JoEllen Welsh University at Albany, New York).
Familial breast cancer, BRCA mutations, Lifestyle factors, Biomarkers, telomere length, oxidative stress, adipose tissue, obesity, metabolic syndrome.