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Professor Johannes Wagener
Associate Professor Consultant, Clinical Microbiology

Publications and Further Research Outputs

Peer-Reviewed Publications

Schroeder I, Dichtl K, Liebchen U, Wagener J, Irlbeck M, Zoller M, Scharf C., Digestive enzymes of fungal origin as a relevant cause of false positive Aspergillus antigen testing in intensive care unit patients., Infection, 49, (2), 2021, p241-248 Journal Article, 2021 DOI

Dunne MR, Wagener J, Loeffler J, Doherty DG, Rogers TR, Unconventional T cells - New players in antifungal immunity, Clinical Immunology, 2021, p108734- Journal Article, 2021 URL DOI

Basch M, Wagner M, Rolland S, Carbonell A, Zeng R, Khosravi S, Schmidt A, Aftab W, Imhof A, Wagener J, Conradt B, Wagener N., Msp1 cooperates with the proteasome for extraction of arrested mitochondrial import intermediates., Molecular biology of the cell, 31, (8), 2020, p753-767 Journal Article, 2020 DOI

Dichtl K, Koeppel MB, Wallner CP, Marx T, Wagener J, Ney L., Food poisoning: an underestimated cause of Boerhaave syndrome., Infection, 48, (1), 2020, p125-128 Journal Article, 2020 DOI

Sturm L, Geißel B, Martin R, Wagener J., Differentially Regulated Transcription Factors and ABC Transporters in a Mitochondrial Dynamics Mutant Can Alter Azole Susceptibility of Aspergillus fumigatus., Frontiers in microbiology, 11, 2020, p1017 Journal Article, 2020 DOI

alpha- and beta-1,3-Glucan Synthesis and Remodeling. in, editor(s)Jean-Paul Latgé , The Fungal Cell Wall: An Armour and a Weapon for Human Fungal Pathogens, Springer International Publishing, 2020, pp53-82 , [Wagener J, Striegler K, Wagener N.] Book Chapter, 2020 DOI

Aspergillus in, Medizinische Mikrobiologie und Infektiologie, 2020, [Johannes Wagener, Oliver Kurzai] Book Chapter, 2020 DOI

Wagener J, Striegler K, Wagener N, "- and ß-1,3-Glucan Synthesis and Remodeling., Current topics in microbiology and immunology, 2020 Journal Article, 2020 DOI

Götz R, Panzer S, Trinks N, Eilts J, Wagener J, Turrà D, Di Pietro A, Sauer M, Terpitz U., Expansion Microscopy for Cell Biology Analysis in Fungi., Frontiers in microbiology, 11, 2020, p574 Journal Article, 2020 DOI

Dichtl K, Forster J, Ormanns S, Horns H, Suerbaum S, Seybold U, Wagener J., Comparison of ß-D-Glucan and Galactomannan in Serum for Detection of Invasive Aspergillosis: Retrospective Analysis with Focus on Early Diagnosis., Journal of fungi (Basel, Switzerland), 6, (4), 2020 Journal Article, 2020 DOI

von Lilienfeld-Toal M, Wagener J, Einsele H, Cornely OA, Kurzai O., Invasive Fungal Infection., Deutsches Arzteblatt international, 116, (16), 2019, p271-278 Journal Article, 2019 DOI

Wagener J, Kurzai O, [Candida auris: Steckbrief eines neuen Pilzes], Deutsches Arzteblatt - SUPPLEMENT: Perspektiven der Infektiologie, 116, (4), 2019, p29-30 Journal Article, 2019

Dichtl K, Seybold U, Wagener J., Serological biomarkers of candidemia: a retrospective evaluation of three assays., Infection, 47, (2), 2019, p217-224 Journal Article, 2019 DOI

Steger M, Bermejo-Jambrina M, Yordanov T, Wagener J, Brakhage AA, Pittl V, Huber LA, Haas H, Lass-Flörl C, Posch W, Wilflingseder D., ß-1,3-glucan-lacking Aspergillus fumigatus mediates an efficient antifungal immune response by activating complement and dendritic cells., Virulence, 10, (1), 2019, p957-969 Journal Article, 2019 DOI

Dichtl K, Seybold U, Ormanns S, Horns H, Wagener J., Evaluation of a Novel Aspergillus Antigen Enzyme-Linked Immunosorbent Assay., Journal of clinical microbiology, 57, (7), 2019 Journal Article, 2019 DOI

Dichtl K, Seybold U, Wagener J., Evaluation of a Turbidimetric ß-d-Glucan Test for Detection of Pneumocystis jirovecii Pneumonia., Journal of clinical microbiology, 56, (7), 2018 Journal Article, 2018 DOI

Wagener J, Walther G, Kurzai O, [Antimykotikaresistenz bei klinisch relevanten Erregern invasiver Pilzinfektionen in Deutschland.], Der Mikrobiologe, 28, 2018, p13-18 Journal Article, 2018

Geißel B, Loiko V, Klugherz I, Zhu Z, Wagener N, Kurzai O, van den Hondel CAMJJ, Wagener J., Azole-induced cell wall carbohydrate patches kill Aspergillus fumigatus., Nature communications, 9, (1), 2018, p3098 Journal Article, 2018 DOI

Ruf D, Brantl V, Wagener J., Mitochondrial Fragmentation in Aspergillus fumigatus as Early Marker of Granulocyte Killing Activity., Frontiers in cellular and infection microbiology, 8, 2018, p128 Journal Article, 2018 DOI

Geißel B, Penka M, Neubauer M, Wagener J., The ER-mitochondria encounter structure contributes to hyphal growth, mitochondrial morphology and virulence of the pathogenic mold Aspergillus fumigatus., International journal of medical microbiology : IJMM, 307, (1), 2017, p37-43 Journal Article, 2017 DOI

Leonhardt Y, Kakoschke SC, Wagener J, Ebel F., Lah is a transmembrane protein and requires Spa10 for stable positioning of Woronin bodies at the septal pore of Aspergillus fumigatus., Scientific reports, 7, 2017, p44179 Journal Article, 2017 DOI

Wagener J, Loiko V., Recent Insights into the Paradoxical Effect of Echinocandins., Journal of fungi (Basel, Switzerland), 4, (1), 2017 Journal Article, 2017 DOI

Loiko V, Wagener J., The Paradoxical Effect of Echinocandins in Aspergillus fumigatus Relies on Recovery of the ß-1,3-Glucan Synthase Fks1., Antimicrobial agents and chemotherapy, 61, (2), 2017 Journal Article, 2017 DOI

Dichtl K, Samantaray S, Wagener J., Cell wall integrity signalling in human pathogenic fungi., Cellular microbiology, 18, (9), 2016, p1228-1238 Journal Article, 2016 DOI

Seybold U, Wagener J, Jung J, Sammet S., Multidrug-resistant organisms among refugees in Germany: we need evidence-based care, not fear-based screening., The Journal of hospital infection, 92, (3), 2016, p229-231 Journal Article, 2016 DOI

Wagener J., Regulation of mitochondrial inner membrane fusion: divergent evolution with similar solutions?, Current genetics, 62, (2), 2016, p291-294 Journal Article, 2016 DOI

Dichtl K, Wagener J, Tschöp J, Ney L., Analysis of peritoneal galactomannan for the diagnosis of Aspergillus peritonitis., Infection, 44, (5), 2016, p683-686 Journal Article, 2016 DOI

Neubauer M, Zhu Z, Penka M, Helmschrott C, Wagener N, Wagener J., Mitochondrial dynamics in the pathogenic mold Aspergillus fumigatus: therapeutic and evolutionary implications., Molecular microbiology, 98, (5), 2015, p930-945 Journal Article, 2015 DOI

Dichtl K, Samantaray S, Aimanianda V, Zhu Z, Prévost MC, Latgé JP, Ebel F, Wagener J., Aspergillus fumigatus devoid of cell wall ß-1,3-glucan is viable, massively sheds galactomannan and is killed by septum formation inhibitors., Molecular microbiology, 95, (3), 2015, p458-471 Journal Article, 2015 DOI

Wagener J, Seybold U., [MRSA - hygiene management, diagnostics and treatment]., Deutsche medizinische Wochenschrift (1946), 139, (13), 2014, p643-51; quiz 652-4 Journal Article, 2014 DOI

The septal cell wall of filamentous fungi in, editor(s)Héctor Manuel Mora-Montes , The Fungal Cell Wall, Nova Science Publishers, 2013, [Beck J, Wagener J, Ebel F] Book Chapter, 2013

Helmschrott C, Sasse A, Samantaray S, Krappmann S, Wagener J., Upgrading fungal gene expression on demand: improved systems for doxycycline-dependent silencing in Aspergillus fumigatus., Applied and environmental microbiology, 79, (5), 2013, p1751-1754 Journal Article, 2013 DOI

Samantaray S, Neubauer M, Helmschrott C, Wagener J., Role of the guanine nucleotide exchange factor Rom2 in cell wall integrity maintenance of Aspergillus fumigatus., Eukaryotic cell, 12, (2), 2013, p288-298 Journal Article, 2013 DOI

Rueping J, Klingenstein A, Wagener J, Kampik A, Kook D., [Iris tumor of unknown origin]., Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 110, (12), 2013, p1185-1187 Journal Article, 2013 DOI

Dichtl K, Helmschrott C, Dirr F, Wagener J., Deciphering cell wall integrity signalling in Aspergillus fumigatus: identification and functional characterization of cell wall stress sensors and relevant Rho GTPases., Molecular microbiology, 83, (3), 2012, p506-519 Journal Article, 2012 DOI

Münchhoff M, Strube H, Wagener J, Bogner JR., [Clostridium-difficile-colitis: more frequent and more severe]., MMW Fortschritte der Medizin, 154, (17), 2012, p61-63 Journal Article, 2012 DOI

Kotz A, Wagener J, Engel J, Routier F, Echtenacher B, Pich A, Rohde M, Hoffmann P, Heesemann J, Ebel F., The mitA gene of Aspergillus fumigatus is required for mannosylation of inositol-phosphorylceramide, but is dispensable for pathogenicity., Fungal genetics and biology : FG & B, 47, (2), 2010, p169-178 Journal Article, 2010 DOI

Kotz A, Wagener J, Engel J, Routier FH, Echtenacher B, Jacobsen I, Heesemann J, Ebel F., Approaching the secrets of N-glycosylation in Aspergillus fumigatus: characterization of the AfOch1 protein., PloS one, 5, (12), 2010, pe15729 Journal Article, 2010 DOI

McCormick A, Heesemann L, Wagener J, Marcos V, Hartl D, Loeffler J, Heesemann J, Ebel F., NETs formed by human neutrophils inhibit growth of the pathogenic mold Aspergillus fumigatus., Microbes and infection, 12, (12-13), 2010, p928-936 Journal Article, 2010 DOI

Dirr F, Echtenacher B, Heesemann J, Hoffmann P, Ebel F, Wagener J., AfMkk2 is required for cell wall integrity signaling, adhesion, and full virulence of the human pathogen Aspergillus fumigatus., International journal of medical microbiology : IJMM, 300, (7), 2010, p496-502 Journal Article, 2010 DOI

Dichtl K, Ebel F, Dirr F, Routier FH, Heesemann J, Wagener J., Farnesol misplaces tip-localized Rho proteins and inhibits cell wall integrity signalling in Aspergillus fumigatus., Molecular microbiology, 76, (5), 2010, p1191-1204 Journal Article, 2010 DOI

Spjuth O, Alvarsson J, Berg A, Eklund M, Kuhn S, Mäsak C, Torrance G, Wagener J, Willighagen EL, Steinbeck C, Wikberg JE., Bioclipse 2: a scriptable integration platform for the life sciences., BMC Bioinformatics, 10, 2009, p397 Journal Article, 2009 DOI

Wagener J, Spjuth O, Willighagen EL, Wikberg JE., XMPP for cloud computing in bioinformatics supporting discovery and invocation of asynchronous web services., BMC Bioinformatics, 10, 2009, p279 Journal Article, 2009 DOI

Wagener J, Echtenacher B, Rohde M, Kotz A, Krappmann S, Heesemann J, Ebel F., The putative alpha-1,2-mannosyltransferase AfMnt1 of the opportunistic fungal pathogen Aspergillus fumigatus is required for cell wall stability and full virulence., Eukaryotic cell, 7, (10), 2008, p1661-1673 Journal Article, 2008 DOI

Duvezin-Caubet S, Koppen M, Wagener J, Zick M, Israel L, Bernacchia A, Jagasia R, Rugarli EI, Imhof A, Neupert W, Langer T, Reichert AS., OPA1 processing reconstituted in yeast depends on the subunit composition of the m-AAA protease in mitochondria., Molecular biology of the cell, 18, (9), 2007, p3582-3590 Journal Article, 2007 DOI

Spjuth O, Helmus T, Willighagen EL, Kuhn S, Eklund M, Wagener J, Murray-Rust P, Steinbeck C, Wikberg JE., Bioclipse: an open source workbench for chemo- and bioinformatics., BMC Bioinformatics, 8, 2007, p59 Journal Article, 2007 DOI

Duvezin-Caubet S, Jagasia R, Wagener J, Hofmann S, Trifunovic A, Hansson A, Chomyn A, Bauer MF, Attardi G, Larsson NG, Neupert W, Reichert AS., Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology., The Journal of biological chemistry, 281, (49), 2006, p37972-37979 Journal Article, 2006 DOI

Non-Peer-Reviewed Publications

Manuel Krone, Julia Gütling, Johannes Wagener, Thiên-Trí Lâm, Christoph Schoen, Ulrich Vogel, August Stich, Florian Wedekink, Jörg Wischhusen, Thomas Kerkau, Niklas Beyersdorf, Silvana Klingler, Simone Backes, Lars Dölken, Georg Gasteiger, Oliver Kurzai, Alexandra Schubert-Unkmeir, Performance of three SARS-CoV-2 immunoassays, three rapid lateral flow tests and a novel bead-based affinity surrogate test for the detection of SARS-CoV-2 antibodies in human serum, 2021 Journal Article, 2021

Research Expertise

Projects

  • Title
    • Cell wall stress response in Aspergillus fumigatus: molecular characterization of the signal transduction pathways
  • Summary
    • Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 194178034, https://gepris.dfg.de/gepris/projekt/194178034
  • Funding Agency
    • DFG, German Research Foundation
  • Date From
    • 05/2011
  • Date To
    • 04/2014
  • Title
    • Molecular characterization of mitochondrial fission and fusion mechanisms in Aspergillus fumigatus and their roles in pathogenicity, viability and stress tolerance
  • Summary
    • Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 249764016, https://gepris.dfg.de/gepris/projekt/249764016
  • Funding Agency
    • DFG, German Research Foundation
  • Date From
    • 05/2014
  • Date To
    • 10/2017
  • Title
    • Resist or die: Identification and functional characterization of cell wall integrity determinants important for the survival of Aspergillus fumigatus challenged by neutrophil granulocytes.
  • Summary
    • Deutsche Forschungsgemeinschaft (DFG) - Project number 430055013, https://gepris.dfg.de/gepris/projekt/430055013
  • Funding Agency
    • DFG, German Research Foundation
  • Date From
    • 06/2020

Keywords

ANTIFUNGAL ACTIVITY; ANTIFUNGAL AGENTS; antifungal drug resistance; ANTIFUNGAL INTERACTION; ANTIFUNGAL RESISTANCE; ANTIFUNGAL THERAPY; ANTIGEN; AZOLE ANTIFUNGAL AGENTS; COINFECTION; diagnostic tool; DIAGNOSTICS; Fungal Infections; fungal morphogenesis; FUNGAL-INFECTIONS; INFECTIOUS DISEASES; Infectious Diseases/Agents; INVASIVE FUNGAL; Microbiology; Mycology and fungal pathogenesis; PULMONARY INFECTION; Serology; Translational microbiology

Recognition

Representations

Co-chairman of the specialized group "Eukaryotic Pathogens" of the German Society of Hygiene and Microbiology (DGHM) Since 2019

Associate Editor for Frontiers in Microbiology Since 2018

Awards and Honours

Young talent award of the specialized group "Eukaryotic Pathogens" of the German Society of Hygiene and Microbiology (DGHM) 2009

Becton Dickinson Research Award "Clinical Microbiology" of the German Society of Hygiene and Microbiology (DGHM; https://www.dghm.org/startseite/dghm-stiftung/voraussetzungen-und-ehemalige-preistraeger-innen/bd-forschungspreis/ ) 2012

Clausthal-Zellerfeld Award on proposal of the Robert Koch Foundation ( https://www.robert-koch-stiftung.de/index.php?article_id=19&clang=0 ) 2016

Forschungsförderpreis of the German-speaking Mycological Society (Deutschsprachige Mykologische Gesellschaft, DMykG; https://www.dmykg.de/forschungsfoerderpreis/ ) 2018

Memberships

German Society of Hygiene and Microbiology (DGHM) 2007 - Present

Deutschsprachige Mykologische Gesellschaft (German-speaking Mycological Society; DMykG) 2017 - Present

Irish Society of Clinical Microbiologists (ISCM) 2020 - Present

Medical Council of Ireland 2020 - Present

Bavarian Medical Association (BLÄK) 2006 – 2020