Dr. Sinead Smith
Ussher Assistant Professor, Clinical Medicine
Ussher Assistant Professor, Pharmacy
Publications and Further Research Outputs
Peer-Reviewed Publications
Molecular Detection of Antibiotic-Resistant Helicobacter pylori. in, Methods Mol Biol. 2283, 2021, pp29 - 36, [Brennan D, O'Morain C, McNamara D, Smith SM.]
Helicobacter pylori Virulence Factor Genotyping. in, Methods Mol Biol. 2283, 2021, pp93 - 106, [FitzGerald R, Sinha C, Yadegar A, Smith SM.]
Nyssen OP, Bordin D, Tepes B, Pérez-Aisa Á, Vaira D, Caldas M, Bujanda L, Castro-Fernandez M, Lerang F, Leja M, Rodrigo L, Rokkas T, Kupcinskas L, Pérez-Lasala J, Jonaitis L, Shvets O, Gasbarrini A, Simsek H, Axon ATR, Buzás G, Machado JC, Niv Y, Boyanova L, Goldis A, Lamy V, Tonkic A, Przytulski K, Beglinger C, Venerito M, Bytzer P, Capelle L, Milosavljević T, Milivojevic V, Veijola L, Molina-Infante J, Vologzhanina L, Fadeenko G, Ariño I, Fiorini G, Garre A, Garrido J, F Pérez C, Puig I, Heluwaert F, Megraud F, O'Morain C, Gisbert JP; Hp-EuReg Investigators, European Registry on Helicobacter pylori management (Hp-EuReg): patterns and trends in first-line empirical eradication prescription and outcomes of 5 years and 21,533 patients, Gut, 70, (1), 2021, p40 - 54
Zaslona Z, Flis E, Nulty C, Kearney J, Fitzgerald R, Douglas AR, McNamara D, Smith S, O'Neill LAJ, Creagh EM., Caspase-4: A Therapeutic Target for Peptic Ulcer Disease, Immunohorizons, 4, (10), 2021, p627 - 633
Purification of Total RNA from Stomach Tissue Biopsies. in, Methods Mol Biol. 2283, 2021, pp51 - 59, [FitzGerald R, Devapal M, Hickey JJ, McNamara D, Kelleher D, Smith SM.]
Sinead Smith, Helicobacter pylori, Springer US, 2021
An Overview of Helicobacter pylori Infection. in, Methods Mol Biol. 2283, 2021, pp1 - 14, [FitzGerald R, Smith SM.]
Alavifard H, Mirzaei N, Yadegar A, Baghaei K, Smith SM, Sadeghi A, Zali MR, Investigation of Clarithromycin Resistance-Associated Mutations and Virulence Genotypes of Helicobacter pylori Isolated from Iranian Population: A Cross-Sectional Study, Current Microbiology, 78, 2021, p244 - 254
Megraud F, Bruyndonckx R, Coenen S, Wittkop L, Huang TD, Hoebeke M, Bénéjat L, Lehours P, Goossens H, Glupczynski Y; European Helicobacter pylori Antimicrobial Susceptibility Testing Working Group., Helicobacter pylori resistance to antibiotics in Europe in 2018 and its relationship to antibiotic consumption in the community, Gut, Apr 9, (gutjnl-2021-324032), 2021
Zhang X, Smith S, Wang X, Zhao B, Wu L, Hu X., Three paralogous clusters of miR-17~92 family microRNAs restrain IL-12-mediated immune defense, Cellular & Molecular Immunology, 2020
Douglas AR, Holleran G, Smith SM, McNamara D., Shared changes in angiogenic factors across gastrointestinal vascular conditions: a pilot study., World Journal of Gastrointestinal Pharmacology & Therapeutics., 11, (3), 2020, p40 - 47
Kang L, Zhang X, Ji L, Kou T, Smith S, Zhao B, Guo X, Pineda-Torra I, Wu L, Hu X., The colonic macrophage transcription factor RBP-J orchestrates intestinal immunity against bacterial pathogens, Journal of Experimental Medicine, 217, (4), 2020, pe20190762
Farzi N, Yadegar A, Sadeghi A, Aghdaei HA, Smith SM, Raymond J, Suzuki H, MR Zali., High Prevalence of Antibiotic Resistance in Iranian Helicobacter pylori Isolates: Importance of Functional and Mutational Analysis of Resistance Genes and Virulence Genotyping, Journal of Clinical Medicine, 8, (11), 2019, pE2004-
Smith SM, O'Morain C, McNamara D, Helicobacter pylori resistance to current therapies., Current Opinion in Gastroenterology, 35, (1), 2019, p6 - 13
Brennan D, Dowd C, O'Morain C, McNamara D*, Smith SM*, Can bacterial virulence factors predict antibiotic resistant Helicobacter pylori infection?, World Journal of Gastroenterology, 24, (9), 2018, p971 - 981
Berthenet E, Yahara K, Thorell K, Pascoe B, Meric G, Mikhail JM, Engstrand L, Enroth H, Burette A, Megraud F, Varon C, Atherton JC, Smith S, Wilkinson TS, Hitchings MD, Falush D, Sheppard SK., A GWAS on Helicobacter pylori strains points to genetic variants associated with gastric cancer risk., BMC Biology, 16, (1), 2018, p84-
Smith SM, Strategies for the purification of membrane proteins, Methods in Molecular Biology, 1485, 2017, p389 - 400
Hussey M, Holleran G, Smith S, Sherlock M, McNamara D, The Role and Regulation of the 11 Beta-Hydroxysteroid Dehydrogenase Enzyme System in Patients with Inflammatory Bowel Disease., Digestive Diseases and Sciences, 62, (12), 2017, p3385 - 3390
Holleran G, Hussey M, Smith S, McNamara D., Assessment of serum angiogenic factors as a diagnostic aid for small bowel angiodysplasia in patients with obscure gastrointestinal bleeding and anaemia., World Journal of Gastrointestinal Pathophysiology, 8, (3), 2017, p127 - 132
Tighe D, Smith S, O'Connor A, Breslin N, Ryan B, McNamara D , Positive relationship between infliximab and adalimumab trough levels at completion of induction therapy with clinical response rates, at a tertiary referral center, JGH Open, 1, (1), 2017, p4 - 10
Tighe D, Hall B, Jeyarajah SK, Smith S, Breslin N, Ryan B, McNamara D., One-Year Clinical Outcomes in an IBD Cohort Who Have Previously Had Anti-TNFa Trough and Antibody Levels Assessed., Inflammatory Bowel Diseases, 23, (7), 2017, p1154 - 1159
Smith SM, Freeley M, Moynagh P, Kelleher D, Differential modulation of Helicobacter pylori lipopolysaccharide-mediated TLR2 signaling by individual Pellino proteins., Helicobacter, 22, (1), 2017, pdoi: 10.1111/hel.12325
Smith S,Boyle B, Brennan D, Buckley M, Crotty P, Doyle M, Farrell R, Hussey M, Kevans D, Malfertheiner P, Megraud F, Nugent S, O'Connor A, O'Morain C, Weston S, McNamara D, The Irish Helicobacter pylori Working Group consensus for the diagnosis and treatment of H. pylori infection in adult patients in Ireland., European Journal of Gastroenterology & Hepatology, 27, (5), 2017, p552 - 559
Brennan DE, Omorogbe J, Hussey M, Tighe D, Holleran G, O'Morain C, Smith SM*, McNamara D*., Molecular detection of Helicobacter pylori antibiotic resistance in stool vs biopsy samples, World Journal of Gastroenterology, 7, (22), 2016, p9214 - 9221
Non-invasive molecular tests for H. pylori in, Hospital Healthcare Europe 2016, London, Cogoro, 2016, pp197 - 199, [Brennan DE, McNamara D, Smith SM]
Miller CH, Smith SM, Elguindy M, Zhang T, Xiang JZ, Hu X, Ivashkiv L, Zhao B., RBP-J-Regulated miR-182 Promotes TNF-α-Induced Osteoclastogenesis, Journal of Immunology, 196, (12), 2016, p4977 - 4986
Verma NK, Fazil MH, Ong ST, Chalasani ML, Low JH, Kottaiswamy A, P P, Kizhakeyil A, Kumar S, Panda AK, Freeley M, Smith SM, Boehm BO, Kelleher D., LFA-1/ICAM-1 Ligation in human T Cells promotes Th1 polarization through a GSK3β signaling-dependent Notch pathway. , Journal of Immunology, 197, (1), 2016, p108 - 118
Shang Y*, Smith S*, Hu X., Role of Notch signaling in regulating innate immunity and inflammation in health and disease, Protein & Cell, 7, (3), 2016, p159 - 174
O'Morain C, Smith S, Heliocbacter pylori treatment failure: the rationale for alternative antibiotics, Digestion, 93, (4), 2016, p309 - 310
Holleran G, Hall B, O'Regan M, Smith S, McNamara D., Expression of Angiogenic Factors in Patients With Sporadic Small Bowel Angiodysplasia., Journal of Clinical Gastroenterology, 49, (10), 2015, p831 - 836
Raftery T, Merrick M, Healy M, Mahmud N, O'Morain C, Smith S, McNamara D, O'Sullivan M., Vitamin D Status Is Associated with Intestinal Inflammation as Measured by Fecal Calprotectin in Crohn's Disease in Clinical Remission., Digestive Diseases and Sciences, 60, (8), 2015, p2427 - 2435
Haider RB, Brennan DE, Omorogbe J, Holleran G, Hall B, O'Morain C, Breslin N, O'Connor HJ, Smith SM*, McNamara D*., A randomized-controlled study to compare the efficacy of sequential therapy with standard triple therapy for Helicobacter pylori eradication in an Irish population., European Journal of Gastroenterology & Hepatology, 27, (11), 2015, p1265 - 1269
Smith SM, An update on the treatment of Helicobacter pylori infection, EMJ Gastroenterology, 4, (1), 2015, p101 - 107
Smith SM, Haider RB, O'Connor H, McNamara D, O'Morain C., Practical treatment of Helicobacter pylori: a balanced view in changing times., European Journal of Gastroenterology & Hepatology, 26, (8), 2014, p819 - 825
Hall B, Holleran G, Chin JL, Smith S, Ryan B, Mahmud N, McNamara D., A prospective 52 week mucosal healing assessment of small bowel Crohn's disease as detected by capsule endoscopy., Journal of Crohn's & Colitis, S1873-9946, (14), 2014, p286-4-
microRNA Profiling: An Overview of Current Technologies and Applications in, editor(s)García-Cañas V, Cifuentes A, Simó C. , Applications of Advanced Omics Technologies: From Genes to Metabolites, Elsevier, 2014, pp23 - 46, [Smith SM, Murray DW]
Campion EM, Hakimjavadi R, Loughran ST, Phelan S, Smith SM, D'Souza BN, Tierney RJ, Bell AI, Cahill PA, Walls D, Repression of the pro-apoptotic cellular BIK/NBK gene by Epstein-Barr virus antagonises TGF-β1-induced B-cell apoptosis, Journal of Virology, 88, (9), 2014, p5001 - 5013
Smith SM, O'Morain C, McNamara D, Antimicrobial susceptibility testing for Helicobacter pylori in times of increasing antibiotic resistance, World Journal of Gastroenterology, 20, (29), 2014, p9912 - 9921
Hall BJ, Holleran GE, Smith SM, Mahmud N, McNamara DA., A prospective 12-week mucosal healing assessment of small bowel Crohn's disease as detected by capsule endoscopy., European Journal of Gastroenterology & Hepatology, 26, (11), 2014, p1253 - 1259
Smith, SM, Role of Toll-like receptors in Helicobacter pylori infection and immunity., World Journal of Gastrointestinal Pathophysiology, 5, (3), 2014, p133 - 146
An overview of microRNA methods: expression profiling and target identification in, editor(s)Virginia Espina & Lance Liotta , Methods in Molecular Biology, Springer, 2012, pp119 - 138, [Smith SM, Murray DW.]
Xu H*, Zhu J*, Smith S*, Foldi J, Zhao B, Chung AY, Outtz H, Kitajewski J, Shi C, Weber S, Saftig P, Li Y, Ozato K, Blobel CP, Ivashkiv LB, Hu X., Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization., Nature Immunology, 13, (7), 2012, p642 - 650
Ryan A, Lynch M, Smith SM, Amu S, Nel HJ, McCoy CE, Dowling JK, Draper E, O'Reilly V, McCarthy C, O'Brien J, Ní Eidhin D, O'Connell MJ, Keogh B, Morton CO, Rogers TR, Fallon PG, O'Neill LA, Kelleher D, Loscher CE., A role for TLR4 in Clostridium difficile infection and the recognition of surface layer proteins., PLOS: Pathogens, 7, (6), 2011, pe1002076-
Strategies for the purification of membrane proteins in, editor(s)Dermot Walls & Sinead Loughran , Methods in Molecular Biology, Springer, 2011, pp485 - 496, [Smith SM]
Smith SM, Moran AP, Duggan S, Ahmed SE, Mohamed AS, Windle HJ, O'Neill L, and Kelleher D., Tribbles 3: A Novel Regulator of TLR2-Mediated Signaling in Response to Helicobacter pylori Lipopolysaccharide , Journal of Immunology, 186, (4), 2011, p2462 - 2471
Loughran ST, Campion EM, D'Souza BN, Smith SM, Vrzalikova K, Wen K, Murray PG, Walls D., Bfl-1 is a crucial pro-survival nuclear factor-κB target gene in Hodgkin/Reed-Sternberg cells., International Journal of Cancer, 129, (12), 2011, p2787 - 2796
Duggan SP, Behan FM, Kirca M, Smith S, Reynolds JV, Long A, Kelleher D, An integrative genomic approach in oesophageal cells identifies TRB3 as a bile acid responsive gene, down regulated in Barrett's oesophagus, which regulates NF-kB activation and cytokine levels., Carcinogenesis, 5, 2010, p936 - 945
Mullaney E, Brown PA, Smith SM, Botting CH, Yamaoka YY, Terres AM, Kelleher DP, Windle HJ, Proteomic and functional characterization of the outer membrane vesicles from the gastric pathogen Helicobacter pylori, Proteomics Clinical Applications, 3, 2009, p785 - 796
Malizia AP, Keating DT, Smith SM, Walls D, Doran PP, Egan JJ., Alveolar Epithelial Cell Injury with Epstein Barr Virus Upregulates TGF{beta}1 Expression., American Journal of Physiology-Lung Cellular and Molecular Physiology, 295, (3), 2008, pL451 - L460
Pegman PM, Smith SM, D'Souza BN, Loughran ST, Maier S, Kempkes B, Cahill PA, Simmons MJ, Gélinas C, Walls D., Epstein-Barr virus nuclear antigen 2 trans-activates the cellular antiapoptotic bfl-1 gene by a CBF1/RBPJ kappa-dependent pathway., Journal of Virology, 80, (16), 2006, p8133 - 8144
Keating DT, Sadlier DM, Patricelli A, Smith SM, Walls D, Egan JJ, Doran PP., Microarray identifies ADAM family members as key responders to TGF-beta1 in alveolar epithelial cells., Respiratory Research, 1, (7), 2006, p114 - 129
D'Souza BN, Edelstein LC, Pegman PM, Smith SM, Loughran ST, Clarke A, Mehl A, Rowe M, Gélinas C, Walls D., Nuclear factor kappa B-dependent activation of the antiapoptotic bfl-1 gene by the Epstein-Barr virus latent membrane protein 1 and activated CD40 receptor., Journal of Virology, 78, (4), 2004, p1800 - 1816