Skip to main content

Trinity College Dublin, The University of Dublin

Trinity Menu Trinity Search



You are here Staff

Dr. Silvin Knight
Research Fellow, Medical Gerontology

Biography

Dr. Silvin Knight currently works as a Research Fellow within the FRAILMatics research programme and The Irish Longitudinal Study on Ageing (TILDA), TCD. His current research interests include quantitative modelling of haemodynamics and autoregulation (measured using Near-infrared Spectroscopy (NIRS), Finometer, and Arterial Spin Labelling (ASL) MRI), as well as developing data-driven and machine learning approaches for the analysis of these neurocardiovascular networks.

Prior to joining TILDA, Silvin's research was largely focused on developing model systems and methodologies for improving / characterising the accuracy and precision of a number of quantitative MRI and ultrasound imaging techniques. Silvin completed his PhD at Trinity College Dublin in 2018 (funded by a four year research scholarship from the Irish Cancer Society), which was focused on improving the sensitivity and specificity of dynamic contrast enhanced (DCE) MRI for the detection of prostate cancer. He received his BSc in Physics (with Medical Physics and Bioengineering) from Dublin Institute of Technology in 2013, graduating with first-class honours. Prior to the career change into physics / biomedical engineering in 2010, he worked for over 10 years in the design / advertising industry as a graphic designer / project manager.

Publications and Further Research Outputs

Peer-Reviewed Publications

Roman Romero-Ortuno, Peter Hartley, James Davis, Silvin P. Knight, Rossella Rizzo, Belinda Hernández, Rose Anne Kenny, Aisling M. O'Halloran, Transitions in frailty phenotype states and components over 8 years: evidence from The Irish Longitudinal Study on Ageing, Archives of Gerontology and Geriatrics, 2021 Journal Article, 2021 DOI TARA - Full Text

David Moloney, Silvin P. Knight, Louise Newman, Rose Anne Kenny, Roman Romero-Ortuno, Eight orthostatic haemodynamic patterns in The Irish Longitudinal Study on Ageing (TILDA): stability and clinical associations after 4 years, Geriatrics, 2021 Journal Article, 2021 DOI TARA - Full Text

Rory Boyle, Siobhan Scarlett, Silvin P Knight, Celine Looze, Yaakov Stern, Ian H Robertson, Kenny Rose Anne, Robert Whelan, Validation of composite proxy measures of cognitive reserve: What can longitudinal cohorts tell us about the association between modifiable dementia risk factors and the ageing, Alzheimer's & Dementia, 2020 Alzheimer's Association International Conference, 16, 2021, ppe041824- Oral Presentation, 2021 DOI URL

Sebastian Moguilner, Silvin P. Knight, James R.C. Davis, Aisling M. O'Halloran, Rose Anne Kenny, Roman Romero-Ortuno, The Importance of Age in the Prediction of Mortality by a Frailty Index: A Machine Learning Approach in the Irish Longitudinal Study on Ageing, Geriatrics , 6, (3), 2021 Journal Article, 2021 DOI URL TARA - Full Text

Silvin P. Knight, Louise Newman, John D. O'Connor, James Davis, Rose Anne Kenny, Roman Romero-Ortuno , Associations between neurocardiovascular signal entropy and physical frailty, Entropy, 2021 Journal Article, 2021 TARA - Full Text DOI

Maasakkers, Carlijn M, Thijssen, Dick HJ, Knight, Silvin P, Newman, Louise, O'Connor, John D, Scarlett, Siobhan, Carey, Daniel, Buckley, Anne, McMorrow, Jason P, Leidhin, Caoilfhionn Ní, Feeney, Joanne, Melis, René JF, Kenny, Rose Anne, Claassen, Jurgen AHR, Looze, Céline De, Hemodynamic and structural brain measures in high and low sedentary older adults, Journal of Cerebral Blood Flow & Metabolism, 2021, p0271678X2110093 Journal Article, 2021 TARA - Full Text DOI

Silvin P. Knight, Eamon Laird, Wilby Williamson, John O'Connor, Louise Newman, Daniel Carey, Celine De Looze, Andrew J. Fagan, Michael A. Chappell, James F. Meaney, Rose Anne Kenny, Obesity is associated with reduced cerebral blood flow - modified by physical activity, Neurobiology of Aging, 2021 Journal Article, 2021 URL DOI

Silvin Knight, Louise Newman, John O'Connor, Rose Anne Kenny, Roman Romero-Ortuno, Approximate entropies of resting state continuous neurocardiovascular physiological signals are associated with physical frailty in older adults, Entropy 2021: The Scientific Tool of the 21st Century, Entropy 2021: The Scientific Tool of the 21st Century, Virtual, 5-7 May 2021, 2021 Oral Presentation, 2021 TARA - Full Text DOI

O'Connor JD, O'Connell MDL, Knight SP, Newman L, Donoghue OA, Kenny RA., Impaired Stabilisation of Orthostatic Cerebral Oxygenation is Associated with Slower Gait Speed: Evidence from The Irish Longitudinal Study on Ageing., The journals of gerontology. Series A, Biological sciences and medical sciences, 2021 Journal Article, 2021 DOI

McDowell CP, Newman L, Monroe DC, O'Connor JD, Knight SP, Kenny RA, Herring MP., The association between generalized anxiety disorder and resting-state prefrontal cortex oxygenation is modified by self-reported physical activity: results from The Irish Longitudinal Study on Ageing., The journals of gerontology. Series A, Biological sciences and medical sciences, 2021 Journal Article, 2021 DOI

Caoilfhionn Ní Leidhin, Jason McMorrow, DanielCarey, LouiseNewman, Wilby Williamson, Andrew J.Fagan, Michael A.Chappell, Rose Anne Kenny, James F. Meaney, Silvin P. Knight, Age-related normative changes in cerebral perfusion: data from The Irish Longitudinal Study on Ageing (TILDA), NeuroImage, 229, (117741), 2021 Journal Article, 2021 DOI TARA - Full Text URL

Boyle R, Knight SP, De Looze C, Carey D, Scarlett S, Stern Y, Robertson IH, Kenny RA, Whelan R., Verbal intelligence is a more robust cross-sectional measure of cognitive reserve than level of education in healthy older adults., Alzheimer's research & therapy, 13, (1), 2021, p128 Journal Article, 2021 DOI

O'Connor JD, O'Connell MD, Romero-Ortuno R, Hernandez B, Newman L, Reilly R, Kenny RA, Knight SP, Functional Analysis of Continuous, High-Resolution Measures in Ageing Research: A Demonstration using Cerebral Oxygenation Data from The Irish Longitudinal Study on Ageing, Frontiers in Human Neuroscience, section Cognitive Neuroscience, 14, (261), 2020 Journal Article, 2020 TARA - Full Text DOI URL

Eamon Laird, Louise Newman, Silvin Knight, John O'Connor, Rose Anne Kenny, Relationship between body mass index and waist-hip ratio with resting-state cerebral oxygenation in an older population, 13th European Nutrition Conference, FENS 2019, Dublin, Ireland, 15-18 October 2019, 2020 Oral Presentation, 2020 URL

F Maguire, R Romero-Ortuno, J O'Connor, RB Reilly, S Knight, R Kenny, Orthostatic cerebrovascular response is altered in frailty: Findings from The Irish Longitudinal Study on Ageing, 68, 2020, ppS6-S7 Oral Presentation, 2020

Fiachra Maguire, Roman Romero-Ortuno, John D O'Connor, Richard B Reilly, Silvin P Knight, Rose-Anne Kenny, One-dimensional statistical parametric mapping identifies impaired orthostatic cerebrovascular and cardiovascular response in frailty index, The Journals of Gerontology, Series A Medical Sciences, 2020 Journal Article, 2020 DOI TARA - Full Text

Rory Boyle, Lee Jollans, Laura M. Rueda-Delgado, Rossella Rizzo, Görsev G. Yener, Jason P. McMorrow, Silvin P. Knight, Daniel Carey, Ian H. Robertson, Derya D. Emek-Savaş, Yaakov Stern, Rose Anne Kenny, Robert Whelan, Brain-predicted age difference score is related to specific cognitive functions: a multi-site replication analysis, Brain Imaging and Behavior, 2020 Journal Article, 2020 URL TARA - Full Text DOI

Céline De Looze, Wilby Williamson, Rebecca Hirst, John O'Connor, Silvin Knight, Cathal McCrory, Daniel Carey, Rose‐Anne Kenny, Impaired orthostatic heart rate recovery is associated with smaller thalamic volume: Results from The Irish Longitudinal Study on Aging (TILDA), Human Brain Mapping, 2020 Journal Article, 2020 TARA - Full Text URL DOI

O'Connor JD, O'Connell MDL, Nolan H, Newman L, Knight SP, Kenny RA., Impact of Standing Speed on the Peripheral and Central Hemodynamic Response to Orthostasis: Evidence From the Irish Longitudinal Study on Ageing., Hypertension (Dallas, Tex. : 1979), 75, (2), 2020, p524-531 Journal Article, 2020 DOI URL

Boyle, Rory, Scarlett, Siobhan, Knight, Silvin P, Looze, Celine, Stern, Yaakov, Robertson, Ian H, Anne, Kenny Rose, Whelan, Robert, Validation of composite proxy measures of cognitive reserve, 16, (S10), 2020 Oral Presentation, 2020 DOI

Hirst, Rebecca J., Whelan, Robert, Boyle, Rory, Setti, Annalisa, Knight, Silvin, O"Connor, John, Williamson, Wilby, McMorrow, Jason, Fagan, Andrew J., Meaney, James F., Kenny, Rose Anne, De Looze, Celine, Newell, Fiona N., Grey matter volume in the right Angular Gyrus is associated with differential patterns of multisensory integration with ageing, Neurobiology of Aging, 2020 Journal Article, 2020 TARA - Full Text DOI

Silvin Knight, Eamon Laird, John O'Connor, Louise Newman, Rose Anne Kenny, Central adiposity is associated with reduced cerebral perfusion: evidence from the Irish Longitudinal Study on Ageing (TILDA), Proceedings of the Nutrition Society, 13th European Nutrition Conference, FENS 2019, Dublin, Ireland, 15-18 October 2019, 79, (OCE2), Cambridge University Press, 2020 Oral Presentation, 2020 URL DOI

Knight, S.P. and Meaney, J.F. and Fagan, A.J., DCE-MRI protocol for constraining absolute pharmacokinetic modeling errors within specific accuracy limits, Medical Physics, 46, (8), 2019, p3592-3602 Journal Article, 2019 DOI

Andrew J Fagan, Silvin P Knight, Matthew Clemence, James F Meaney, Accuracy and precision of DCE-MRI acquired with golden-angle radial k-space under-sampling, International Society for Magnetic Resonance in Medicine (ISMRM) 27th Annual Meeting, Montreal, Canada, 11-16 May 2019, 2019 Poster, 2019 URL

Silvin P. Knight, James F. Meaney, Andrew J. Fagan, Optimal temporal resolution for accurate AIF measurement and error-constrained pharmacokinetic modelling of DCE data, International Society for Magnetic Resonance in Medicine (ISMRM) 27th Annual Meeting, Montreal, Canada, 11-16 May 2019, 2019 Oral Presentation, 2019 URL

Robert Briggs, Anne Buckley, Silvin Knight, Jim Meaney, Sean Kennelly, Rose Anne Kenny, The Relationship between Late Life Depressive Symptoms and Cerebral White Matter Disease is Modified by Systemic and Orthostatic Blood Pressure, Age and Ageing, 48(Supplement_3), 2019, ppiii1-iii16 Oral Presentation, 2019 DOI URL

Silvin P. Knight, James F. Meaney, Andrew J. Fagan, Quantification of the absolute accuracy and precision of DCE-MRI measurements of the arterial input function, International Society for Magnetic Resonance in Medicine (ISMRM) 26th Annual Meeting, Paris, France, 16-21 June 2018, 2018 Poster, 2018 URL

Silvin P. Knight, Matthew Clemence, James F. Meaney, Andrew J. Fagan, Quantification of the effects of golden-angle radial k-space under-sampling on DCE-MRI accuracy and precision, Medical Physics, The American Association of Physicists in Medicine (AAPM): 60th annual meeting and exhibition, Nashville, TN, USA, 29th July - 2nd Aug, 45, (6), 2018 Oral Presentation, 2018 URL DOI

Knight, S.P. and Browne, J.E. and Meaney, J.F.M. and Fagan, A.J., Quantitative effects of acquisition duration and temporal resolution on the measurement accuracy of prostate dynamic contrast-enhanced MRI data: a phantom study, Magnetic Resonance Materials in Physics, Biology and Medicine, 30, (5), 2017, p461-471 Journal Article, 2017 URL DOI

Silvin P. Knight, Jacinta E. Browne, James F. Meaney, Andrew J. Fagan, Effects of sampling frequency on the accuracy of phenomenological and pharmacokinetic parameters derived from dynamic contrast enhanced MRI data, Physica Medica: European Journal of Medical Physics, 42, 2017, pp353 Oral Presentation, 2017 URL DOI

Silvin Knight, Jacinta Browne, James Meaney, Andrew Fagan, Quantitative evaluation of the effect of temporal resolution and acquisition duration on the accuracy of DCE-MRI measurements in a prostate phantom, International Society for Magnetic Resonance in Medicine (ISMRM) 25th Annual Meeting, Honolulu, HI, USA, 22-27 April 2017 , 2017 Poster, 2017 URL

Silvin P. Knight, Jacinta E. Browne, James F. Meaney, David S. Smith, Andrew J. Fagan, Error quantification in pharmacokinetic parameters derived from DCE-MRI data using a novel anthropomorphic dynamic prostate phantom, Physica Medica: European Journal of Medical Physics, 32, (7), 2016, pp949 Oral Presentation, 2016 URL DOI

Silvin P. Knight, Jacinta E. Browne, James F. Meaney, David S. Smith, Andrew J. Fagan, A Novel Prostate DCE-MRI Flow Phantom for the Quantitative Evaluation of Pharmacokinetic Parameters, International Society for Magnetic Resonance in Medicine (ISMRM) 24th Annual Meeting, Singapore, 7-13th May 2016, 2016 Oral Presentation, 2016 URL

Silvin P. Knight, James F. Meaney, Andrew J. Fagan, Rapid prototyping: Offering new opportunities in phantom design and construction, Physica Medica: European Journal of Medical Physics, 32, (2), 2016, pp427 Poster, 2016 DOI URL

Knight SP, Browne JE, Meaney JF, Smith DS, Fagan AJ, A novel anthropomorphic flow phantom for the quantitative evaluation of prostate DCE-MRI acquisition techniques, Physics in Medicine and Biology, 61, 2016, p7468 - 7483 Journal Article, 2016 URL DOI

Silvin P. Knight, Jacinta E. Browne, James F. Meaney, Andrew J. Fagan, Effect of temporal resolution and sampling duration on pharmacokinetic parameters derived from prostate DCE-MRI data: a quantitative phantom study, The European Society for Magnetic Resonance in Medicine and Biology (ESMRMB) 2016, Vienna, Austria, Sept 29th - Oct 1st , 2016 Oral Presentation, 2016 URL

Silvin P. Knight, James F. Meaney, Andrew J. Fagan, A flow phantom for the quantitative validation of DCE-MRI techniques, Physica Medica: European Journal of Medical Physics, 32, (2), 2016, pp417 Oral Presentation, 2016 URL DOI

Silvin P. Knight, James F. Meaney, Andrew J. Fagan, A novel flow phantom for the quantitative evaluation of prostate DCE-MRI techniques, The European Society for Magnetic Resonance in Medicine and Biology (ESMRMB) 2015, Edinburgh, Scotland, 2015 Oral Presentation, 2015 URL

Silvin P. Knight, James F. Meaney, Andrew J. Fagan, A review of dynamic contrast enhanced MRI for the diagnosis of prostate cancer, Physica Medica: European Journal of Medical Physics, 30, (6), 2014, pp721 Poster, 2014 URL DOI