Skip to main content

Trinity College Dublin, The University of Dublin

Trinity Menu Trinity Search



You are here Staff

Dr. James Phelan
Research Fellow, Clinical Medicine

Publications and Further Research Outputs

Peer-Reviewed Publications

Noel E. Donlon and Andrew Sheppard and Maria Davern and Fiona O'Connell and James J. Phelan and Robert Power and Timothy Nugent and Kate Dinneen and John Aird and John Greene and Paul Nevins Selvadurai and Anshul Bhardwaj and Emma K. Foley and Narayanasamy Ravi and Claire L. Donohoe and John V. Reynolds and Joanne Lysaght and Jacintha O'Sullivan and Margaret R. Dunne, Linking Circulating Serum Proteins with Clinical Outcomes in Esophageal Adenocarcinoma"An Emerging Role for Chemokines, Cancers, 12, (11), 2020, p3356 Journal Article, 2020 TARA - Full Text

Cahill, C.*, Phelan, J.J.* and Keane, J, Understanding and exploiting the effect of tuberculosis antimicrobials on host mitochondrial function and bioenergetics, Frontiers in Cellular and Infection Microbiology, 2020 Journal Article, 2020 TARA - Full Text URL DOI

Phelan J.J., McQuaid, K., Kenny C., Gogan K.M., Cox D.J., Basdeo S.A., O'Leary S., Tazoll S.C., Ó Maoldomhnaigh C., O'Sullivan M.P., O'Neill LA, O'Sullivan M.J. & Keane J., Desferrioxamine supports metabolic function in primary human macrophages infected with Mycobacterium tuberculosis, Frontiers in Immunology, 2020 Journal Article, 2020 URL TARA - Full Text DOI

Dunne M.R.*, Phelan J.J.*, Michielsen A.J., Maguire A.A., Dunne C., Martin P., Noonan S., Tosetto M., Geraghty R., Fennelly D., Sheahan K., Ryan E.J., O'Sullivan J. (joint 1st author *), Characterising the prognostic potential of HLA-DR during colorectal cancer development., Cancer Immunology Immunotherapy, 2020 Journal Article, 2020 TARA - Full Text URL DOI

Gillian Barber, Akanksha Anand, Katarzyna Oficjalska, James J Phelan, Aisling B Heeran, Ewelina Flis, Niamh E Clarke, Jenny A Watson, Julia Strangmann, Brian Flood, Hazel O'Neill, Dermot O'Toole, Finbar MacCarthy, Narayanasamy Ravi, John V Reynolds, Elaine W Kay, Michael Quante, Jacintha O'Sullivan, Emma M Creagh, Characterizing caspase‑1 involvement during esophageal disease progressio, Cancer Immunology, Immunotherapy, 2020 Journal Article, 2020 URL DOI

Petrasca A, Phelan J.J., Ansboro S, Veale D.J., Fearon U., Fletcher J.M., Targeting bioenergetics prevents CD4 T cell-mediated activation of synovial fibroblasts in rheumatoid arthritis., Rheumatology, 2020 Journal Article, 2020 DOI URL

Cox, D.J., Coleman, A.M., Gogan, K.M., Phelan, J.J., Maoldomhnaigh, C., Dunne, P.J., Basdeo, S.A. and Keane, J., Inhibiting histone deacetylases in human macrophages promotes glycolysis, IL-1β and T helper cell responses to Mycobacterium tuberculosis, Frontiers in Immunology, 2020 Journal Article, 2020 DOI TARA - Full Text URL

Melo, Ashanty M., O'Brien, Aisling M., Phelan, James J., Kennedy, Susan A., Wood, Nicole A. W., Veerapen, Natacha, Besra, Gurdyal S., Clarke, Niamh E., Foley, Emma K., Ravi, Akshaya, MacCarthy, Finbar, O'Toole, Dermot, Ravi, Narayamasami, Reynolds, John V., Conroy, Melissa J., Hogan, Andrew E., O'Sullivan, Jacintha, Dunne, Margaret R., Mucosal-Associated Invariant T Cells Display Diminished Effector Capacity in Oesophageal Adenocarcinoma, Frontiers in Immunology, 10, 2019 Journal Article, 2019 TARA - Full Text DOI

Naoimh J. O'Farrell, James J. Phelan, Ronan Feighery, Brendan Doyle, Sarah L. Picardo, Ravi Narayanasamy, Dermot O'Toole, John V. Reynolds, Jacintha O'Sullivan, Differential expression profiles of oxidative stress levels, 8-oxo-dG and 4-HNE, in Barrett's esophagus compared to esophageal adenocarcinoma, International Journal of Molecular Sciences, 2019 Journal Article, 2019 URL TARA - Full Text DOI

Francesco Caiazza, Katarzyna Oficjalska, Miriam Tosetto, James J. Phelan, SinéadNoonan, Petra Martin, Kate Killick, Laura Breen, Fiona O'Neill, Blathnaid Nolan, Simon Furney, Robert Power, David Fennelly, Charles S. Craik, Jacintha O'Sullivan, Kieran Sheahan, Glen A. Doherty, Elizabeth J. Ryan, KH-Type Splicing Regulatory Protein Controls Colorectal Cancer Cell Growth and Modulates the Tumor Microenvironment, The American Journal of Pathology, 2019 Journal Article, 2019 URL TARA - Full Text DOI

James J. Phelan, Finbar MacCarthy, Dermot O'Toole, Narayanasamy Ravi, John V. Reynolds and Jacintha O'Sullivan, The Mitochondrial Genes BAK1, FIS1 and SFN are Linked with Alterations in Mitochondrial Membrane Potential in Barrett's Esophagus, International Journal of Molecular Sciences, 19, (11), 2018 Journal Article, 2018 TARA - Full Text URL DOI

Phelan JJ, Basdeo SA, Tazoll SC, McGivern S, Saborido JR and Keane J, Modulating Iron for Metabolic Support of TB Host Defense, Frontiers in Immunology, 2018 Journal Article, 2018 DOI TARA - Full Text URL

Dowling CM, Hayes SL, Phelan J.J., Cathcart MC, Finn SP, Mehigan B, McCormick P, Coffey JC, O'Sullivan J and Kiely PA, Expression of protein kinase C gamma promotes cell migration in colon cancer, Oncotarget, 8, (42), 2017, p72096-72107 Journal Article, 2017 DOI URL

Widdowson, W.M., McGowan, A., Phelan, J.J., Boran, G., Reynolds, J.V., and Gibney, J., Vascular disease is associated with the expression of genes for intestinal cholesterol transport and metabolism, Journal of Clinical Endocrinology & Metabolism, 102, (1), 2017, p326-335 Journal Article, 2017 DOI URL TARA - Full Text

Biniecka M, Canavan M, McGarry T, Gao W, McCormick J, Cregan S, Gallagher L, Smith T, Phelan JJ, Ryan J, O'Sullivan J, Ng CT, Veale DJ, Fearon U, Dysregulated bioenergetics: a key regulator of joint inflammation., 75, (12), 2016, p2192-2200 Journal Article, 2016 DOI

O'Farrell NJ, Feighery R, Picardo SL, Lynam-Lennon, N., Biniecka, M., McGarrigle, S., Phelan J.J., MacCarthy, F., O'Toole, D., Fox EJ, Ravi, N., Reynolds JV, O'Sullivan JN., 'Changes in mitochondrial stability during the progression of the Barrett's esophagus sequence'., BMC Cancer, 2016 Journal Article, 2016 TARA - Full Text DOI URL

Dowling, C.M., Phelan, J.J., Callender, J.A., Cathcart, M.C., Mehigan, B., McCormick, P., Dalton, T., Coffey, J.C. Newton A.C., O'Sullivan, J. and Kiely P.A., 'Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival'., Oncotarget, 7, (15), 2016, p20919 - 20933 Journal Article, 2016 DOI URL TARA - Full Text

Dowling C, Phelan J, Cathcart M, Mehigan B, McCormick P, Dalton T, Coffey C, Newton A, O'Sullivan J and Kiely P., Protein Kinase C Beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival, Oncotarget, 7, 2016, p20919-20933 Journal Article, 2016 TARA - Full Text DOI

Phelan JJ, Feighery R, Eldin OS, Meachair SÓ, Cannon A, Byrne R, MacCarthy F, O'Toole D, Reynolds JV, O'Sullivan J, Examining the connectivity between different cellular processes in the Barrett tissue microenvironment., Cancer letters, 371, (2), 2016, p334-46 Journal Article, 2016 DOI

Biniecka, M., Canavan, M., McGarry, T., Gao, W., McCormick, J., Cregan, S., Gallagher, L., Smith T., Phelan, J.J., Ryan, J., O'Sullivan, J., Nq, C.T., Veale, D.J. and Fearon, U., 'Dysregulated bioenergetics: a key regulator of joint inflammation'., Annals of Rheumatic diseases., 75, (12), 2016, p2192-2200 Journal Article, 2016 DOI URL TARA - Full Text

O'Farrell N.J, Feighery R, Picardo S.L, Lynam-Lennon N, Biniecka M, McGarrigle S.A, Phelan J.J, MacCarthy F, O'Toole D, Fox E.J, Ravi N, Reynolds J.V, O'Sullivan J, Changes in mitochondrial stability during the progression of the Barrett's esophagus disease sequence, BMC Cancer, 16, (1), 2016, p497- Journal Article, 2016 TARA - Full Text DOI URL

Phelan, J.J., Feighery, R., Eldin, O.S., MacCarthy, F., O'Toole, D., Reynolds, J.V. and O'Sulllivan, J., 'Examining the connectivity between different cellular processes in the Barrett tissue microenvironment: energy metabolism, hypoxia, inflammation, p53 and obesity'., Cancer Letters, 371, (2), 2016, p334 - 346 Journal Article, 2016 URL TARA - Full Text DOI

Phelan JJ, O'Hanlon C, Reynolds JV, O'Sullivan J., 'The role of energy metabolism in driving disease progression in inflammatory, hypoxic and angiogenic microenvironments'., Gastro Open Journal, 1, (2), 2015, p44-58 Journal Article, 2015 DOI TARA - Full Text URL

O'Sullivan KE, Phelan JJ, O'Hanlon C, Lysaght J, O'Sullivan JN, Reynolds JV., The role of inflammation in cancer of the esophagus., Expert Reviews Gastroenterology Hepatology, 8, (7), 2014, p749 - 760 Journal Article, 2014 DOI TARA - Full Text

Lynam-Lennon N, Maher SG, Maguire A, Phelan J, Muldoon C, Reynolds JV, O'Sullivan J., 'Altered Mitochondrial Function and Energy Metabolism Is Associated with a Radioresistant Phenotype in Oesophageal Adenocarcinoma'., PLOS ONE, 9, (6), 2014 Journal Article, 2014 URL TARA - Full Text DOI

Lynam-Lennon, N., Maher, S.G., Maguire, A., (...), Reynolds, J.V., O'Sullivan, J., Altered mitochondrial function and energy metabolism is associated with a radioresistant phenotype in oesophageal adenocarcinoma, PLoS ONE , 9, (6), 2014, pe100738- Journal Article, 2014 DOI TARA - Full Text

O'Sullivan KE, Phelan JJ, O'Hanlon C, Lysaght J, O'Sullivan JN, Reynolds JV., The role of inflammation in cancer of the esophagus. Expert review of gastroenterology & hepatology., Expert review of gastroenterology & hepatology, 8, (7), 2014, p749 - 760 Journal Article, 2014 URL DOI

Phelan JJ, MacCarthy F, Feighery R, O'Farrell NJ, Lynam-Lennon N, Doyle B, O'Toole D, Ravi N, Reynolds JV, O'Sullivan J., Differential expression of mitochondrial energy metabolism profiles across the metaplasia-dysplasia-adenocarcinoma disease sequence in Barrett's oesophagus'., Cancer Letters, 354, (1), 2014, p122 - 131 Journal Article, 2014 URL DOI TARA - Full Text

Research Expertise

Projects

  • Title
    • Evaluating the immunometabolic potential of desferrioxamine to augment antibiotic treatment against Mycobacterium tuberculosis
  • Summary
    • Tuberculosis (TB) remains a global scourge causing more than one million deaths annually. TB therapy is characterised by a long duration of treatment and the administration of a number of antibiotic drugs to overcome drug resistance. The increasing prevalence of drug-resistant TB demonstrates that current treatments are inadequate and there is an urgent need for novel therapies. Research is now focused on the development of host-directed therapies (HDTs) which can be used in combination with existing antimicrobials, with a special focus on promoting host defense, particularly cellular metabolism. Immunometabolic reprogramming is integral to TB host defense and fundamental to eradicating TB infection. Moreover, TB pathophysiology is interconnected with iron metabolism. Iron is crucial for the survival of Mycobacterium tuberculosis (Mtb), the bacteria that causes TB disease. Iron chelation has therefore been suggested as a HDT. In addition to its direct effects on iron availability, it is hypothesised that iron chelators can also enhance immunometabolism through the stabilisation of HIF1α. We propose to evaluate the immunometabolic potential of anti-TB agents in combination with the iron chelator, desferrioxamine (DFX), to examine if such anti-TB/DFX combinatorial agents can augment antibiotic efficacy in human alveolar macrophages infected with clinical isolates of drug-resistant Mtb.
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • 1st April 2019
  • Date To
    • 31st March 2020

Keywords

Angiogenesis, oncology, cardiovascular biology, inflammation; ANTI-CANCER DRUG DESIGN; ANTICANCER DRUGS; BACTERIAL INFECTION; BARRETTS ESOPHAGUS; BARRETTS-ESOPHAGUS; Biochemistry, metabolism; BOVINE TUBERCULOSIS; CANCER; CANCER CELL-LINE; CANCER PATIENTS; CANCER RISK; CANCER SUSCEPTIBILITY GENE; CANCER TREATMENT; CANCER-CELLS; CANCER-PATIENTS; CANCERS; Carbohydrates, Other Macromolecules Metabolism; CHEST INFECTIONS; CHRONIC INFLAMMATION; COINFECTION; Colorectal Cancer; Cytology and Cancerology; Development of novel anti-cancer drugs; Development of novel neo-adjuvant treatments for oesophageal and prostate cancer; DYSPLASIA; ELECTRON-TRANSPORT; ENERGY-METABOLISM; ESOPHAGEAL CANCER; FATTY ACID; FATTY ACID OXIDATION; FATTY-ACID SYNTHESIS; GASTRO-OESOPHAGEAL REFLUX; Gastro-oesophageal reflux disease; GASTROESOPHAGEAL REFLUX; GASTROESOPHAGEAL REFLUX DISEASE; GLUCOSE METABOLISM; GLUCOSE-METABOLISM; GLUTAMATE; GLUTAMINE; GLUTAMINE METABOLISM; GLUTAMINE SYNTHETASE; Glycolysis; HELICOBACTER PYLORI INFECTION; IMMUNOLOGY; Immunology, Immunotherapy; Immunometabolism; INFECTION; Inflammation; INFLAMMATION-INDUCED EXPRESSION; Innate immunology; INTESTINAL INFECTIONS; INTESTINAL INFLAMMATION; L-GLUTAMINE; L-TRYPTOPHAN; LACTATE AND ACETATE METABOLISM; Lipid metabolism; LIPID-METABOLISM; LUNG INFECTION; metabolism; Metabolism and metabolic diseases; Metabolism, Amino Acid; Metabolism, Lipid; Metabolism, Mineral; Metabolism, Nucleotide; Metabolism, Protein; Mitochondria; MITOCHONDRIAL; mitochondrial aspartate/glutamate; MITOCHONDRIAL COMPLEX I; MITOCHONDRIAL COMPLEX-I; MITOCHONDRIAL DNA; MITOCHONDRIAL DNA (MTDNA); Mitochondrial fission & fusion mechanisms; Mitochondrial function; MITOCHONDRIAL INNER MEMBRANE; MITOCHONDRIAL MATRIX; MITOCHONDRIAL OUTER MEMBRANE; MITOCHONDRIAL OUTER-MEMBRANE; MITOCHONDRIAL RESPIRATION; MITOCHONDRIAL RESPIRATORY COMPLEX I; MITOCHONDRIAL RESPIRATORY-CHAIN; MITOCHONDRIAL UNCOUPLING PROTEIN; MITOCHONDRIAL-DNA; MITOCHONDRIAL-MEMBRANE POTENTIAL; Molecular Immunology; MYCOBACTERIUM INFECTION; Mycobacterium tuberculosis; MYCOBACTERIUM-TUBERCULOSIS; Oesophageal Cancer; OXIDATIVE INJURY; OXIDATIVE PHOSPHORYLATION; OXIDATIVE POTENTIAL; OXIDATIVE STRESS; OXIDATIVE-METABOLISM; OXIDATIVE-PHOSPHORYLATION; PENTOSE-PHOSPHATE PATHWAY; PREVENTION OF TUBERCULOSIS; PULMONARY TUBERCULOSIS; RESISTANT TUBERCULOSIS; RESPIRATORY INFECTION; TB immunology; TRIACYLGLYCEROL METABOLISM; TRYPTOPHAN; Tuberculosis; TUBERCULOSIS TRANSMISSION; Tumor Immunology; Tumour Biology/ Immunology; Tumour immunology and immunotherapy

Recognition

Representations

I have presented six posters at international conferences including the BSI (2017, Brighton), the 7th & 9th National Barrett's Symposium (2013 &2015, London), Keystone's Tumor Metabolism Conference (2014, Canada), at the European Association of Cancer Research (EACR23) (2014, Munich) and at Abcam's Cancer and Metabolism Conference (2013, Amsterdam).

Awards and Honours

SFI/EI Technology Innovation Development Award (TIDA) 2019

British Society for Immunology - Travel Award (£1000) November 2018