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Dr. Niamh O'Connell
Clinical Senior Lecturer, Clinical Medicine

Publications and Further Research Outputs

Peer-Reviewed Publications

Townsend L, Fogarty H, Dyer A, Martin-Loeches I, Bannan C, Nadarajan P, Bergin C, O' Farrelly C, Conlon N, Bourke NM, Ward SE, Byrne M, Ryan K, O' Donnell JS, Prolonged elevation of D-dimer Levels in Convalescent COVID-19 patients is Independent of the Acute Phase Response., Journal of thrombosis and haemostasis : JTH, 2021 Journal Article, 2021

Kennedy M, O†Gorman P, Monaghan A, Lavin M, O†Mahony B, O†Connell N.M, O†Donnell J.S, Turecek P.L, Gormley J, A systematic review of physical activity in people with haemophilia and its relationship with bleeding phenotype and treatment regimen, Haemophilia, 2021 Journal Article, 2021 DOI URL

O'Donovan M, Bergin C, Quinn E, Singleton E, Roche S, Benson J, Bird R, Byrne M, Duggan C, Gilmore R, Ryan K, O'Donnell JS, O'Connell NM, Real-world outcomes with recombinant factor IX Fc fusion protein (rFIXFc) prophylaxis: Longitudinal follow-up in a national adult cohort., Haemophilia : the official journal of the World Federation of Hemophilia, 2021 Journal Article, 2021

Doherty D, Lavin M, O'Sullivan JM, Ryan K, O'Connell NM, Dougall A, Byrne M, Rafferty M, Doyle MM, Di Paola J, James PD, O'Donnell JS, Management of elective procedures in low von Willebrand factor patients in the LoVIC study., Journal of thrombosis and haemostasis : JTH, 2021 Journal Article, 2021

Kempton C, Trask P, Parnes A, Niggli M, Campinha-Bacote A, U Callaghan M, O'Connell N, Paz-Priel I, Mahlangu JN, Development and testing of the Satisfaction Questionnaire with Intravenous or Subcutaneous Hemophilia Injection and results from the Phase 3 HAVEN 3 study of emicizumab prophylaxis in persons with haemophilia A without FVIII inhibitors., Haemophilia : the official journal of the World Federation of Hemophilia, 2021 Journal Article, 2021

O'Donovan M, Buckley C, Benson J, Roche S, McGowan M, Parkinson L, Byrne P, Rooney G, Bergin C, Walsh D, Bird R, McGroarty F, Fogarty H, Smyth E, O'Connell NM, Telehealth for delivery of haemophilia comprehensive care during the COVID-19 pandemic., Haemophilia : the official journal of the World Federation of Hemophilia, 2020 Journal Article, 2020

Fogarty, Helen, Townsend, Liam, Ni Cheallaigh, Cliona, Bergin, Colm, Martin"Loeches, Ignacio, Browne, Paul, Bacon, Christopher L., Gaule, Richard, Gillett, Alexander, Byrne, Mary, Ryan, Kevin, O'Connell, Niamh, O'Sullivan, Jamie M., Conlon, Niall, O'Donnell, James S., More on COVID"19 coagulopathy in Caucasian patients, British Journal of Haematology, 189, (6), 2020, p1060-1061 Journal Article, 2020 DOI

Helen Fogarty, Liam Townsend, Cliona Ni Cheallaigh, Colm Bergin, Ignacio Martin‐Loeches, Paul Browne, Christopher L Bacon, Richard Gaule, Alexander Gillett, Mary Byrne, Kevin Ryan, Niamh O'Connell, Jamie M O'Sullivan, Niall Conlon, James S O'Donnell, COVID 19 coagulopathy in caucasian patients, British Journal of Haematology, 89, (6), 2020, p1044 - 1049 Journal Article, 2020

Steven W. Pipe, Michael Recht, Nigel S. Key, Frank W.G. Leebeek, Giancarlo Castaman, Susan U. Lattimore, Paul Van Der Valk, Kathelijne Peerlinck, Michiel Coppens, Niamh O'Connell, John Pasi, Peter Kampmann, Karina Meijer, Annette von Drygalski, Guy Young, Cedric Hermans, Jan Astermark, Robert Klamroth, Richard S. Lemons, Nathan Visweshwar, Shelley Crary, Rashid Kazmi, Emily Symington, Miguel A. Escobar, Esteban Gomez, Rebecca Kruse-Jarres, Adam Kotowski, Doris Quon, Michael Wang, Allison P. Wheeler, Eileen K Sawyer, Stephanie Verweij, Valerie Colletta, Naghmana Bajma, Robert Gut, Wolfgang A. Miesbach, First Data from the Phase 3 HOPE-B Gene Therapy Trial: Efficacy and Safety of Etranacogene Dezaparvovec (AAV5-Padua hFIX variant; AMT-061) in Adults with Severe or Moderate-Severe Hemophilia B Treated Irrespective of Pre-Existing Anti-Capsid Neutralizing Antibodies, The American Society of Hematoloy, Dec 2020, 2020 Oral Presentation, 2020

Aguila S, Lavin M, Dalton N, Patmore S, Chion A, Trahan GD, Jones KL, Keenan C, Brophy TM, O'Connell NM, Ryan K, Byrne M, Nolan M, Patel A, O'Donnell JS, Increased galactose expression and enhanced clearance in patients with low von Willebrand factor., Blood, 2019 Journal Article, 2019 DOI

Niamh M. O{', Acquired Factor Xiii Deficiency: An Uncommon But Easily Missed Cause Of Severe Bleeding, Irish medical journal, 2018 Journal Article, 2018

Fogarty H, Doyle MM, Campbell R, Keenan C, White B, Ryan K, O'Donnell JS, Slevin J, O'Keeffe D, O'Connell NM, Lavin M, Management of combined factor V and factor VIII deficiency in pregnancy., Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2018 Journal Article, 2018 DOI

Doherty D, Singleton E, Byrne M, Ryan K, O'Connell NM, O'Donnell JS, Lavin M, Missed at first Glanz: Glanzmann thrombasthenia initially misdiagnosed as Von Willebrand Disease., Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis, 2018 Journal Article, 2018 DOI

Kevane B, O'Connell N, The current and future role of plasma-derived clotting factor concentrate in the treatment of haemophilia A., Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis, 2018 Journal Article, 2018 DOI

Lavin M, Aguila S, Dalton N, Nolan M, Byrne M, Ryan K, White B, O'Connell NM, O'Sullivan JM, Di Paola J, James PD, O'Donnell JS, Significant gynecological bleeding in women with low von Willebrand factor levels., Blood advances, 2018 Journal Article, 2018 DOI

Lavin, M. and Ryan, K. and White, B. and Byrne, M. and O'Connell, N.M. and O'Donnell, J.S., A role for intravenous immunoglobulin in the treatment of Acquired Von Willebrand Syndrome associated with IgM gammopathy, Haemophilia, 2017, pe22-e25 Journal Article, 2017 DOI

Appleby, N., Groarke, E., Crowley, M., Wahab, F. A., McCann, A. M., Egan, L., Gough, D., McMahon, G., O'Donghaile, D., O'Keeffe, D., O'Connell, N., Reversal of warfarin anticoagulation using prothrombin complex concentrate at 25 IU kg"1 : results of the RAPID study, Transfusion Medicine, 27, (1), 2017, p66-71 Journal Article, 2017 DOI

Lavin M, Aguila S, Schneppenheim S, Dalton N, Jones KL, O'Sullivan JM, O'Connell NM, Ryan K, White B, Byrne M, Rafferty M, Doyle MM, Nolan M, O'Donnell JS, Novel insights into the clinical phenotype and pathophysiology underlying low VWF levels., Blood, 2017 Journal Article, 2017 DOI

Grogan A, Coughlan M, Prizeman G, O'Connell N, O'Mahony N, Quinn K, McKee G, The patients' perspective of international normalized ratio self-testing, remote communication of test results and confidence to move to self-management., Journal of clinical nursing, 2017 Journal Article, 2017 DOI

Lavin M, Brophy T.M, Rawley O, O'Sullivan J.M, Hayden P.J, Browne P.V, Ryan K, O'Connell N, O'Donnell J.S, Lenalidomide as a novel treatment for refractory acquired von Willebrand syndrome associated with monoclonal gammopathy, Journal of Thrombosis and Haemostasis, 14, (6), 2016, p1200 - 1205 Journal Article, 2016 DOI URL

C Logan, J Kavanagh, N O'Connell, N McEniff, JM Ryan, M Guiney, K Ryan, O Seery, J O'Donnell, B White., Out of sight, out of mind? An audit which proposes a follow-up and management pathway for Inferior Vena Cava Filters. , Thrombosis, MS No 483870, 2016, pdoi:10.1155/2016/6538456 Journal Article, 2016

Lavin, M. and Kavanagh, J. and Beddy, P. and O'Connell, N.M. and O'Donnell, J.S., Recurrent lower limb venous thrombosis associated with a congenitally absent infrarenal inferior vena cava, QJM, 109, (1), 2016, p57 Journal Article, 2016 DOI

Lavin, M. and Jenkins, P.V. and Keenan, C. and White, B. and Betts, D.R. and O'Donnell, J.S. and O'Connell, N.M., X-linked moyamoya syndrome associated with severe haemophilia A, Haemophilia, 22, (1), 2016, pe51-e54 Journal Article, 2016 DOI

Lavin, M. and Jenkins, P.V. and Healy, M.L. and Byrne, M. and O'Connell, N.M. and O'Donnell, J.S., Age-related factor IX correction in symptomatic female carriers with haemophilia B Leyden, Haemophilia, 21, (6), 2015, pe498-e500 Journal Article, 2015 DOI

Mumford AD, Ackroyd S, Alikhan R, Bowles L, Chowdary P, Grainger J, Mainwaring J, Mathias M, O'Connell N, BCSH Committee, Guideline for the diagnosis and management of the rare coagulation disorders: a United Kingdom Haemophilia Centre Doctors' Organization guideline on behalf of the British Committee for Standards in Haematology., British journal of haematology, 2014 Journal Article, 2014

O'Reilly MA, McHale C, Almazmi A, Hameed A, Benjamin D, O'Connell N, Murphy P, Quinn J, Thornton P, O'Gorman P, Frankova H, Sargent J, Verburgh E, McHugh J, Evans P, Enright H., A 5-day: the favourable way?, Annals of hematology, 93, (9), 2014, p1619-1620 Journal Article, 2014 DOI

Niamh M. O{', Allogeneic Hematopoietic Stem Cell Transplantation for a BCR-FGFR1 Myeloproliferative Neoplasm Presenting as Acute Lymphoblastic Leukemia., Case reports in hematology, 2012 Journal Article, 2012 DOI

O'Donnell DM, O'Connell NM, O'Donnell JS, Oral rivaroxaban for pulmonary embolism., The New England journal of medicine, 2012 Journal Article, 2012

Qasim A, Duggan M, O'Connell N, O'Driscoll A, Clinical conditions and patient factors significantly influence diagnostic utility of D-dimer in venous thromboembolism., Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2009 Journal Article, 2009

O'Connell NM, Riddell AF, Pascoe G, Perry DJ, Lee CA, Recombinant factor VIIa to prevent surgical bleeding in factor XI deficiency., Haemophilia : the official journal of the World Federation of Hemophilia, 2008 Journal Article, 2008

Hayden PJ, O'Connell NM, O'Brien DA, O'Rourke P, Lawlor E, Browne PV, The value of autofluorescence as a diagnostic feature of acute promyelocytic leukemia., Haematologica, 2006 Journal Article, 2006

Kadir RA, Kingman CE, Chi C, O'connell NM, Riddell A, Lee CA, Economides DL, Screening for factor XI deficiency amongst pregnant women of Ashkenazi Jewish origin., Haemophilia : the official journal of the World Federation of Hemophilia, 2006 Journal Article, 2006

O'Connell NM, Saunders RE, Lee CA, Perry DJ, Perkins SJ, Structural interpretation of 42 mutations causing factor XI deficiency using homology modeling., Journal of thrombosis and haemostasis : JTH, 2005 Journal Article, 2005

Saunders RE, O'Connell NM, Lee CA, Perry DJ, Perkins SJ, Factor XI deficiency database: an interactive web database of mutations, phenotypes, and structural analysis tools., Human mutation, 2005 Journal Article, 2005

Basic principles of coagulation in, editor(s)Denise O'Shaughnessy Michael Makris David Lillicrap , Practical Haemostasis, Oxford University Press, 2004, [Niamh O'Connell] Book Chapter, 2004

Salomon O, Zivelin A, Livnat T, Dardik R, Loewenthal R, Avishai O, Steinberg DM, Rosove MH, O'Connell N, Lee CA, Seligsohn U, Prevalence, causes, and characterization of factor XI inhibitors in patients with inherited factor XI deficiency., Blood, 2003 Journal Article, 2003 DOI

Laffan M, O'Connell NM, Perry DJ, Hodgson AJ, O'Shaughnessy D, Smith OP, Analysis and results of the recombinant factor VIIa extended-use registry., Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2003 Journal Article, 2003 DOI

O'Connell NM, Perry DJ, Hodgson AJ, O'Shaughnessy DF, Laffan MA, Smith OP, Recombinant FVIIa in the management of uncontrolled hemorrhage., Transfusion, 2003 Journal Article, 2003 DOI

O'Connell NM, Factor XI deficiency--from molecular genetics to clinical management., Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2003 Journal Article, 2003 DOI

N. O'Connell, J. Chen, M. Byrne, E. O'Shea, H. Smyth and O. P. Smith, Massive pseudotumour resection with recombinant factor VIIa (NovoSeven) cover, British journal of haematology, 116, (3), 2002, p645-8 Journal Article, 2002 URL

N. O'Connell, C. Mc Mahon, J. Smith, K. Khair, I. Hann, R. Liesner and O. P. Smith, Recombinant factor VIIa in the management of surgery and acute bleeding episodes in children with haemophilia and high responding inhibitors, British journal of haematology, 116, (3), 2002, p632-5 Journal Article, 2002 URL

Niamh M. O{', Childhood refractory autoimmune haemolytic anaemia: is there a role for anti-CD20 therapy (rituximab)?, British journal of haematology, 2002 Journal Article, 2002 DOI

Y. L. Woo, B. White, R. Corbally, M. Byrne, N. O'Connell, E. O'Shea, B. L. Sheppard, J. Bonnar and O. P. Smith, von Willebrand's disease: an important cause of dysfunctional uterine bleeding, Blood coagulation & fibrinolysis, 13, (2), 2002, p89-93 Journal Article, 2002 URL

Haematological emergencies in, editor(s)R.A.J.Spence P.Johnston , Oncological Emergencies, Oxford University Press, 2002, [Niamh O'Connell, Shaun R. McCann] Book Chapter, 2002

Niamh M. O{', Fatal Pancreatic Necrosis after Pregnancy-Associated Thrombotic Thrombocytopenic Purpura., Hematology (Amsterdam, Netherlands), 2001 Journal Article, 2001 DOI

N. O'Connell, N. Gardiner, C. Duggan, H. Enright, M. J. Kennedy, S. R. McCann, P. A. Daly and P. V. Browne, Effective progenitor cell mobilization in lymphoproliferative disorders using ifosfamide, epirubicin and etoposide (IEV), European journal of haematology Supplementum, (64), 2001, p33-6 Journal Article, 2001 URL

Grace A, O'Connell N, Byrne P, Prendiville W, O'Donnell R, Royston D, Walsh CB, Leader M, Kay E, Malignant lymphoma of the cervix. An unusual presentation and a rare disease., European journal of gynaecological oncology, 1999 Journal Article, 1999

Non-Peer-Reviewed Publications

Groarke E, O'Connell N, Practical management of venous thromboembolism in patients with cancer, Cancer Professional, 11, (1), 2017, p14 - 16 Journal Article, 2017

Bakhai A, Lip GH, McCormack T, Rose P, Eames M, O'Connell N, Harrison-Tiffin N, Fortes-Mayer G, Fitzmaurice D, Fay M, Defining consensus in anticoagulation service delivery for patients with atrial fibrillation, Prescriber, 2012 Journal Article, 2012

Research Expertise

Keywords

Antiphopholipid syndrome; Coagulation biochemistry and disorders; Haemotology; Health informatics; Health outcomes; Thrombosis and haemostasis

Recognition

Representations

Chair of the Irish Haematology Society Coagulation Special Interest group November 2019

Chair of the Haemophilia Product Selection and Monitoring advisory Board February 2018

Member of the National Haemophilia Council July 2018

Member of the Medical and Scientific Advisory Board of the Irish Blood Transfusion service 2010

Grant application reviewer for the UK MRC 2021

Member of the committee of the Haematology association of Ireland 2005

Journal Reviewer (Haemophilia, Clinical and Applied Thrombosis and Haemostasis, American Journal of Hematology, Anesthesia and Analgesia Irish Medical Journal) 2011

Advisor to the National Immunisation Advisory Committee 2021

Awards and Honours

The Dr. Henry Hutchinson Stewart Scholarship in Anatomy 1991

The Charles Medals in Anatomy and Physiology 1991

The Pfizer Gold Medal in Psychiatry 1993

The P.F. Fitzpatrick Prize in Social and Preventive medicine 1993

The R.G.G. Barry prize in Paediatrics 1994

The James M. O'Donovan Prize 1994

The Blayney Prize 1994

University College Cork Scholarships 1989, 1990,1991,1993

Memberships

The Haematology Association of Ireland 1997 – Current

The International Society for Thrombosis and Haemostasis 2001 – Current

The World Federation of Haemophilia 2001 – Current

The Irish Haematology Society 2004 – Current

The U.K. Haemophilia Centre Doctors Organisation 2010 – Current

The European Association for Haemophilia and Allied Disorders 2018 – Current