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Dr. Suzanne Cloonan
Assoc Professor in Respiratory Biochemis, Clinical Medicine

Publications and Further Research Outputs

Peer-Reviewed Publications

Bessman, Nicholas J and Mathieu, Jacques R R and Renassia, Cyril and Zhou, Lei and Fung, Thomas C and Fernandez, Keith C and Austin, Christine and Moeller, Jesper B and Zumerle, Sara and Louis, Sabine and Vaulont, Sophie and Ajami, Nadim J and Sokol, Harry and Putzel, Gregory G and Arvedson, Tara and Sockolow, Robbyn E and Lakhal-Littleton, Samira and Cloonan, Suzanne M and Arora, Manish and Peyssonnaux, Carole and Sonnenberg, Gregory F, Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing, Science (New York, N.Y.), 368, (6487), 2020, p186â€"189 Journal Article, 2020 DOI

O'Beirne, Sarah L and Kikkers, Sarah Ann and Oromendia, Clara and Salit, Jacqueline and Rostmai, Mahboubeh R and Ballman, Karla V and Kaner, Robert J and Crystal, Ronald G and Cloonan, Suzanne M, Alveolar Macrophage Immunometabolism and Lung Function Impairment in Smoking and Chronic Obstructive Pulmonary Disease, American journal of respiratory and critical care medicine, 201, (6), 2020, p735â€"739 Journal Article, 2020 DOI

Zhang, William Z and Cloonan, Suzanne M, To "Fe"ed or Not to "Fe"ed: Iron Depletion Exacerbates Emphysema Development in Murine Smoke Model, American journal of respiratory cell and molecular biology, 62, (5), 2020, p541â€"542 Journal Article, 2020 DOI

Zhang, William Z and Rice, Michelle C and Hoffman, Katherine L and Oromendia, Clara and Barjaktarevic, Igor Z and Wells, J Michael and Hastie, Annette T and Labaki, Wassim W and Cooper, Christopher B and Comellas, Alejandro P and Criner, Gerard J and Krishnan, Jerry A and Paine, Robert and Hansel, Nadia N and Bowler, Russell P and Barr, R Graham and Peters, Stephen P and Woodruff, Prescott G and Curtis, Jeffrey L and Han, Meilan K and Ballman, Karla V and Martinez, Fernando J and Choi, Augustine Mk and Nakahira, Kiichi and Cloonan, Suzanne M and Choi, Mary E and {SPIROMICS Investigators, Association of urine mitochondrial DNA with clinical measures of COPD in the SPIROMICS cohort, JCI insight, 5, (3), 2020 Journal Article, 2020 DOI

Aghapour, Mahyar and Remels, Alexander H V and Pouwels, Simon D and Bruder, Dunja and Hiemstra, Pieter S and Cloonan, Suzanne M and Heijink, Irene H, Mitochondria: at the crossroads of regulating lung epithelial cell function in chronic obstructive pulmonary disease, American journal of physiology. Lung cellular and molecular physiology, 318, (1), 2020, pL149â€"L164 Journal Article, 2020 DOI

Zhang William Z, Oromendia Clar, Kikkers Sarah An, Butler James J, O†Beirne Sara, Kim Kihwa, O†Neal Wanda K, Freeman Christine M, Christenson Stephanie A, Peters Stephen P, Wells J. Michae, Doerschuk Clair, Putcha Nirupam, Barjaktarevic Igo, Woodruff Prescott G, Cooper Christopher B, Bowler Russell P, Comellas Alejandro P, Criner Gerard J, Paine Rober, Hansel Nadia N, Han Meilan K, Crystal Ronald G, Kaner Robert J, Ballman Karla V, Curtis Jeffrey L, Martinez Fernando J, Cloonan Suzanne M, Increased airway iron parameters and risk for exacerbation in COPD: an analysis from SPIROMICS, Scientific Reports, 10, (1), 2020, p10562- Journal Article, 2020 DOI URL

Zhang, William Z and Butler, James J and Cloonan, Suzanne M, Smoking-induced iron dysregulation in the lung, Free radical biology & medicine, 133, 2019, p238â€"247 Journal Article, 2019 DOI

Faner, Rosa and Morrow, Jarrett D and Casas-Recasens, Sandra and Cloonan, Suzanne M and Noell, Guillaume and López-Giraldo, Alejandra and Tal-Singer, Ruth and Miller, Bruce E and Silverman, Edwin K and Agustí, Alvar and Hersh, Craig P, Do sputum or circulating blood samples reflect the pulmonary transcriptomic differences of COPD patients? A multi-tissue transcriptomic network META-analysis, Respiratory research, 20, (1), 2019, p5 Journal Article, 2019 DOI

Ward, Diane M and Cloonan, Suzanne M, Mitochondrial Iron in Human Health and Disease, Annual review of physiology, 81, 2019, p453â€"482 Journal Article, 2019 DOI

Plataki, Maria and Fan, LiChao and Sanchez, Elizabeth and Huang, Ziling and Torres, Lisa K and Imamura, Mitsuru and Zhu, Yizhang and Cohen, David E and Cloonan, Suzanne M and Choi, Augustine Mk, Fatty acid synthase downregulation contributes to acute lung injury in murine diet-induced obesity, JCI insight, 5, 2019 Journal Article, 2019 DOI

Najafinobar, Neda and Venkatesan, Shalini and von Sydow, Lena and Klarqvist, Magnus and Olsson, Henric and Zhou, Xiao-Hong and Cloonan, Suzanne M and Malmberg, Per, ToF-SIMS mediated analysis of human lung tissue reveals increased iron deposition in COPD (GOLD IV) patients, Scientific reports, 9, (1), 2019, p10060 Journal Article, 2019 DOI

Chung, Kuei-Pin and Hsu, Chia-Lang and Fan, Li-Chao and Huang, Ziling and Bhatia, Divya and Chen, Yi-Jung and Hisata, Shu and Cho, Soo Jung and Nakahira, Kiichi and Imamura, Mitsuru and Choi, Mary E and Yu, Chong-Jen and Cloonan, Suzanne M and Choi, Augustine M K, Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis, Nature communications, 10, (1), 2019, p3390 Journal Article, 2019 DOI

Pabón, Maria A and Patino, Edwin and Bhatia, Divya and Rojas-Quintero, Joselyn and Ma, Kevin C and Finkelsztein, Eli J and Osorio, Juan C and Malick, Faryal and Polverino, Francesca and Owen, Caroline A and Ryter, Stefan W and Choi, Augustine Mk and Cloonan, Suzanne M and Choi, Mary E, Beclin-1 regulates cigarette smoke-induced kidney injury in a murine model of chronic obstructive pulmonary disease, JCI insight, 3, (18), 2018 Journal Article, 2018 DOI

Ma, Kevin C and Schenck, Edward J and Siempos, Ilias I and Cloonan, Suzanne M and Finkelsztein, Eli J and Pabon, Maria A and Oromendia, Clara and Ballman, Karla V and Baron, Rebecca M and Fredenburgh, Laura E and Higuera, Angelica and Lee, Jin Young and Chung, Chi Ryang and Jeon, Kyeongman and Yang, Jeong Hoon and Howrylak, Judie A and Huh, Jin-Won and Suh, Gee Young and Choi, Augustine Mk, Circulating RIPK3 levels are associated with mortality and organ failure during critical illness, JCI insight, 3, (13), 2018 Journal Article, 2018 DOI

Racanelli, Alexandra C and Kikkers, Sarah Ann and Choi, Augustine M K and Cloonan, Suzanne M, Autophagy and inflammation in chronic respiratory disease, Autophagy, 14, (2), 2018, p221â€"232 Journal Article, 2018 DOI

Cloonan, Suzanne M, Circulating Mitochondrial DNA as a Mechanism-based, Prognostic Biomarker for Idiopathic Pulmonary Fibrosis, American journal of respiratory and critical care medicine, 196, (12), 2017, p1502â€"1504 Journal Article, 2017 DOI

Cloonan, Suzanne M and Mumby, Sharon and Adcock, Ian M and Choi, Augustine M K and Chung, Kian Fan and Quinlan, Gregory J, The "Iron"-y of Iron Overload and Iron Deficiency in Chronic Obstructive Pulmonary Disease, American journal of respiratory and critical care medicine, 196, (9), 2017, p1103â€"1112 Journal Article, 2017 DOI

Morrow, Jarrett D and Zhou, Xiaobo and Lao, Taotao and Jiang, Zhiqiang and DeMeo, Dawn L and Cho, Michael H and Qiu, Weiliang and Cloonan, Suzanne and Pinto-Plata, Victor and Celli, Bartholome and Marchetti, Nathaniel and Criner, Gerard J and Bueno, Raphael and Washko, George R and Glass, Kimberly and Quackenbush, John and Choi, Augustine M K and Silverman, Edwin K and Hersh, Craig P, Functional interactors of three genome-wide association study genes are differentially expressed in severe chronic obstructive pulmonary disease lung tissue, Scientific reports, 7, 2017, p44232 Journal Article, 2017 DOI

Cloonan, Suzanne M and Choi, Augustine M K, Mitochondria in lung disease, The Journal of clinical investigation, 126, (3), 2016, p809â€"820 Journal Article, 2016 DOI

Cloonan, Suzanne M and Glass, Kimberly and Laucho-Contreras, Maria E and Bhashyam, Abhiram R and Cervo, Morgan and Pabón, Maria A and Konrad, Csaba and Polverino, Francesca and Siempos, Ilias I and Perez, Elizabeth and Mizumura, Kenji and Ghosh, Manik C and Parameswaran, Harikrishnan and Williams, Niamh C and Rooney, Kristen T and Chen, Zhi-Hua and Goldklang, Monica P and Yuan, Guo-Cheng and Moore, Stephen C and Demeo, Dawn L and Rouault, Tracey A and D'Armiento, Jeanine M and Schon, Eric A and Manfredi, Giovanni and Quackenbush, John and Mahmood, Ashfaq and Silverman, Edwin K and Owen, Caroline A and Choi, Augustine M K, Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice, Nature medicine, 22, (2), 2016, p163â€"174 Journal Article, 2016 DOI

Mizumura, Kenji and Cloonan, Suzanne and Choi, Mary E and Hashimoto, Shu and Nakahira, Kiichi and Ryter, Stefan W and Choi, Augustine M K, Autophagy: Friend or Foe in Lung Disease?, Annals of the American Thoracic Society, 13 Suppl 1, 2016, pS40â€"7 Journal Article, 2016 DOI

Cloonan SM, Elmes RB, Erby M, Bright SA, Poynton FE, Nolan DE, Quinn SJ, Gunnlaugsson T, Williams DC, Detailed Biological Profiling of a Photoactivated and Apoptosis Inducing pdppz Ruthenium(II) Polypyridyl Complex in Cancer Cells., Journal of medicinal chemistry, 58, (11), 2015, p4494-505 Journal Article, 2015 DOI

Mizumura, Kenji and Cloonan, Suzanne M and Nakahira, Kiichi and Bhashyam, Abhiram R and Cervo, Morgan and Kitada, Tohru and Glass, Kimberly and Owen, Caroline A and Mahmood, Ashfaq and Washko, George R and Hashimoto, Shu and Ryter, Stefan W and Choi, Augustine M K, Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD, The Journal of clinical investigation, 124, (9), 2014, p3987â€"4003 Journal Article, 2014 DOI

Cloonan, Suzanne M and Lam, Hilaire C and Ryter, Stefan W and Choi, Augustine M, "Ciliophagy": The consumption of cilia components by autophagy, Autophagy, 10, (3), 2014, p532â€"534 Journal Article, 2014 DOI

Nakahira, Kiichi and Cloonan, Suzanne M and Mizumura, Kenji and Choi, Augustine M K and Ryter, Stefan W, Autophagy: a crucial moderator of redox balance, inflammation, and apoptosis in lung disease, Antioxidants & redox signaling, 20, (3), 2014, p474â€"494 Journal Article, 2014 DOI

Lam, Hilaire C and Cloonan, Suzanne M and Bhashyam, Abhiram R and Haspel, Jeffery A and Singh, Anju and Sathirapongsasuti, J Fah and Cervo, Morgan and Yao, Hongwei and Chung, Anna L and Mizumura, Kenji and An, Chang Hyeok and Shan, Bin and Franks, Jonathan M and Haley, Kathleen J and Owen, Caroline A and Tesfaigzi, Yohannes and Washko, George R and Quackenbush, John and Silverman, Edwin K and Rahman, Irfan and Kim, Hong Pyo and Mahmood, Ashfaq and Biswal, Shyam S and Ryter, Stefan W and Choi, Augustine M K, Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction, The Journal of clinical investigation, 123, (12), 2013, p5212â€"5230 Journal Article, 2013 DOI

Cloonan, Suzanne M and Choi, Augustine M K, Mitochondria: sensors and mediators of innate immune receptor signaling, Current opinion in microbiology, 16, (3), 2013, p327â€"338 Journal Article, 2013 DOI

Cloonan, Suzanne M and Choi, Augustine M K, Mitochondria: sensors and mediators of innate immune receptor signaling, Current opinion in microbiology, 16, (3), 2013, p327â€"338 Journal Article, 2013 DOI

Ryter, Stefan W and Cloonan, Suzanne M and Choi, Augustine M K, Autophagy: a critical regulator of cellular metabolism and homeostasis, Molecules and cells, 36, (1), 2013, p7â€"16 Journal Article, 2013 DOI

Mizumura, Kenji and Cloonan, Suzanne M and Haspel, Jeffrey A and Choi, Augustine M K, The emerging importance of autophagy in pulmonary diseases, Chest, 142, (5), 2012, p1289â€"1299 Journal Article, 2012 DOI

Breen, JM, Clerac R, Zhang L, Cloonan SM, Kennedy E, Feeney M, McCabe T, Williams DC, and Schmitt, W., Self-assembly of hybrid organic-inorganic polyoxovanadates: functionalised mixed-valent clusters and molecular cages, Dalton Transactions, 41, (10), 2012, p2918 - 2926 Journal Article, 2012

Cloonan, Suzanne M and Choi, Augustine M K, Mitochondria: commanders of innate immunity and disease?, Current opinion in immunology, 24, (1), 2012, p32â€"40 Journal Article, 2012 DOI

Constantin, Myrna and Choi, Alexander J S and Cloonan, Suzanne M and Ryter, Stefan W, Therapeutic potential of heme oxygenase-1/carbon monoxide in lung disease, International journal of hypertension, 2012, 2012, p859235 Journal Article, 2012 DOI

Yvonne M. McNamara, Suzanne M. Cloonan, Andrew J.S. Knox, John J. Keating, Stephen G. Butler, Günther H. Peters, Mary J. Meegan and D. Clive Williams, Synthesis and serotonin transporter activity of 1,3-bis(aryl)-2-nitro-1-propenes as a new class of anticancer agents, Bioorganic & Medicinal Chemistry, 19, (3), 2011, p1328 - 1348 Journal Article, 2011 TARA - Full Text

Robert B. P. Elmes, Marialuisa Erby, Suzanne M. Cloonan, Susan J. Quinn, D. Clive Williams and Thorfinnur Gunnlaugsson, Quaternarized pdppz: Synthesis, DNA-binding and biological studies of a novel dppz derivative that causes cellular death upon light irradiation, Chemical Communications, 47, 2011, p686 - 688 Journal Article, 2011 DOI TARA - Full Text

Elmes RB, Orange KN, Cloonan SM, Williams DC, Gunnlaugsson T, Luminescent ruthenium(II) polypyridyl functionalized gold nanoparticles; their DNA binding abilities and application as cellular imaging agents., Journal of the American Chemical Society, 133, (40), 2011, p15862 - 15865 Journal Article, 2011 DOI

Cloonan, S.M. and Williams, D.C. , The antidepressants maprotiline and fluoxetine induce Type-II autophagic cell death in drug resistant Burkitt's lymphoma, International Journal of Cancer, 128, 2011, p1712 - 1723 Journal Article, 2011

Suzanne M. Cloonan, John J. Keating, John E. O'Brien, Desmond Corrigan, Pierce V Kavanagh, D. Clive Williams and Mary J. Meegan, Synthesis and in vitro toxicity of 4-MTA, its characteristic clandestine synthesis byproducts and related sulphur substituted á-alkylthioamphetamines, Bioorganic and Medicinal Chemistry, 18, 2010, p4009 - 4031 Journal Article, 2010 TARA - Full Text

Cloonan SM, Drozgowska A, Fayne D, Williams DC, The antidepressants maprotiline and fluoxetine have potent selective antiproliferative effects against Burkitt lymphoma independently of the norepinephrine and serotonin transporters., Leukemia & lymphoma, 51, (3), 2010, p523-39 Journal Article, 2010

Seema-Maria Nathwani , Suzanne M. Cloonan, Maeve Stronach, Giuseppe Campiani, Mark Lawler, D. Clive Williams and Daniela M. Zisterer, Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce cell cycle arrest and apoptosis in prostate cancer cells. , Oncology Reports, 24, 2010, p1499 - 1507 Journal Article, 2010 DOI

Cloonan, SM, Keating, JJ, Butler, SG, Knox, AJ, Jørgensen, AM, Peters, GH, Rai, D, Corrigan, D, Lloyd, DG, Williams, DC, Meegan, MJ, Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents., European Journal of Medicinal Chemistry, 44, 2009, p4862 - 4888 Journal Article, 2009 DOI

Mulligan JM, Greene LM, Cloonan S, Mc Gee MM, Onnis V, Campiani G, Fattorusso C, Lawler MP, Williams C, Zisterer DM., Identification of tubulin as the molecular target of pro-apoptotic pyrrolo-1,5-benzoxazepines., Molecular Pharmacology, 70, (1), 2006, p60-70 Journal Article, 2006 DOI

Research Expertise

Projects

  • Title
    • The Ironome of the Lung and Disease Pathogenesis
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • 2019
  • Date To
    • 2024

Keywords

Acute Respiratory Distress Syndrome; ALVEOLAR EPITHELIAL-CELLS; ALVEOLAR MACROPHAGES; COPD; EMPHYSEMA; FERRITIN; Hepcidin; HUMAN ALVEOLAR MACROPHAGES; HYPEROXIA; IDIOPATHIC PULMONARY FIBROSIS; IRON; IRON CHELATORS; IRON CLUSTER; IRON COMPLEXES; IRON DEFICIENCY; Mitochondria; MITOCHONDRIAL ACTIVITY; MITOCHONDRIAL DNA; Mitochondrial fission & fusion mechanisms; Mitochondrial function; MITOCHONDRIAL INNER MEMBRANE; MITOCHONDRIAL MATRIX; MITOCHONDRIAL OUTER MEMBRANE; MITOCHONDRIAL RELEASE; MITOCHONDRIAL RESPIRATION; mitophagy; PULMONARY FIBROSIS; PULMONARY-EMPHYSEMA; SERUM FERRITIN

Recognition

Representations

CONFERENCE ORGANIZER International Biorion Society Scientific Committee member 2019

CONFERENCE CHAIR/ORGANIZER European Respiratory Society Annual Conference 2019 Scientific Reviewer 2019

CONFERENCE CHAIR/ORGANIZER American Thoracic Society Annual Conference Program Committee 2017

CONFERENCE CHAIR/ORGANIZER American Thoracic Society Annual Conference. Chair: Mitochondrial dysfunction and reprogramming in lung aging and disease. 2018

Associate Editor Respiratory Research 2018

Editor, Scientific Reports 2019

Awards and Honours

Science Foundation ireland Future Research Leaders Award 2019

Kellen Fellowship for Junior Faculty, Weill Cornell Medicine 2018

Weill Cornell Medicine, Junior Faculty Development Grant 2015

American Thoracic Society Annual Conference Best Abstract Award 2013 and 2014

National Cancer Institute/Health Research Board Ireland Molecular Prevention/Control Scholar 2009

Irish Association for Cancer Research Travel Award 2019

Memberships

European Respiratory Society 2012 – current

American Thoracic Society 2011 – current

Bioiron Society 2014 – current

American Association for Cancer Research 2008 – 2012

Irish Association for Cancer Research 2007 – 2012