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Dr. Nollaig Bourke
Ussher Assistant Professor, Medical Gerontology

Publications and Further Research Outputs

Peer-Reviewed Publications

McCrory, C., Fiorito, G., Layte, R., Vineis, P. & Kenny, R.A. , Epigenetic clocks and allostatic load reveal potential sex-specific drivers of biological ageing, Journal of Gerontology: Biological Sciences, 2019 Journal Article, 2019

Adam Dyer, Isabelle Killane, Nollaig Bourke, Conor Woods, James Gibney, Desmond O'Neill, Richard Reilly, Sean Kennelly, 84 Does Dual-Task Gait Speed Predict Cognitive Performance in Midlife Type 2 Diabetes? Baseline Results from the ENBIND Study, Age and Ageing, 48, (Supplement{\_), 2019, piii1--iii16 Journal Article, 2019

Marks ZRC, Campbell N, deWeerd NA, Lim SS, Gearing LJ, Bourke NM, Hertzog PJ., PROPERTIES AND FUNCTIONS OF THE NOVEL TYPE I INTERFERON EPSILON., Seminars in immunology, 2019, p101328 Journal Article, 2019 DOI

Adam Dyer, Isabella Batten, Isabelle Killane, Conor Woods, James Gibney, Desmond O'Neill, Richard Reilly, Nollaig Bourke, Sean Kennelly, 85 Linking Diabetes and Dementia Risk: A Role for Aß-42 Induced Activation of the NLRP3 Inflammasome? Results from the ENBIND Study, Age and Ageing, 48, (Supplement{\_), 2019, piii17--iii65 Journal Article, 2019

Jennifer K. Dowling, Michelle D. Tate, Sarah Rosli, Nollaig M. Bourke, Natalie Bitto, Mario A. Lauterbach, Shane Cheung, Thomas Ve, Bostjan Kobe, Douglas Golenbock, Ashley Mansell, The Single Nucleotide Polymorphism Mal-D96N Mice Provide New Insights into Functionality of Mal in TLR Immune Responses, The Journal of Immunology, 2019, pji1800501 Journal Article, 2019

Layte, R. and McCrory, C., Ni Cheallaigh, C., Bourke, N., Kivimaki, M., Ribeiro, A.I, Stringhini, S. and Vineis, P., A Comparative Analysis of the Status Anxiety Hypothesis of Socio-Economic Inequalities in Health Based on 18,349 individuals in Four Countries and Five Cohort Studies, Scientific Reports, Online, 2019, p1 - 6 Journal Article, 2019 URL

Cumming HE, Bourke NM, Type I IFNs in the female reproductive tract: The first line of defense in an ever-changing battleground., Journal of leukocyte biology, 2018 Journal Article, 2018

Nollaig M Bourke, Sharon L Achilles, Stephanie U Huang, Helen E Cumming, Irene Papageorgio, Linden J Gearing, Suruchi Thakore, Niamh E Mangan, Sam Mesiano, Paul J Hertzog, Human IFN": Spaciotemporal expression, hormone regulation and innate immunity in the female reproductive tract, 2018 Journal Article, 2018

Bourke NM, Napoletano S, Bannan C, Ahmed S, Bergin C, McKnight à , Stevenson NJ., Control of HIV infection by IFN-alpha: implications for latency and a cure., Cellular and molecular life sciences : CMLS, 75, (5), 2018, p775-783 Journal Article, 2018 TARA - Full Text DOI

de Weerd NA, Matthews AY, Pattie PR, Bourke NM, Lim SS, Vivian JP, Rossjohn J, Hertzog PJ., A hot spot on interferon α/β receptor subunit 1 (IFNAR1) underpins its interaction with interferon-β and dictates signaling., The Journal of Biological Chemistry, 292, (18), 2017, p7554 - 7565 Journal Article, 2017 TARA - Full Text DOI

Mahony R, Gargan S, Roberts KL, Bourke N, Keating SE, Bowie AG, O'Farrelly C, Stevenson NJ, A novel anti-viral role for STAT3 in IFN-alpha signalling responses. , Cellular and Molecular Life Sciences, 74, (9), 2017, p1755 - 1764 Journal Article, 2017 DOI TARA - Full Text

New Interferons in, editor(s)Michael J. H. Ratcliffe , Encyclopedia of Immunobiology, Elsevier, 2016, pp501 - 508, [Paul J. Hertzog, Nollaig M. Bourke, Nicole A. de Weerd, Niamh E. Mangan] Book Chapter, 2016

Bourke NM, O'Neill M, Sarwar S, Norris S, Stewart S, Hegarty JE, Stevenson NJ and O'Farrelly C., In vitro Blood Cell Responsiveness to IFN-alpha Predicts Clinical Response Independently of IL28B in Hepatitis C Virus Genotype 1 Infected Patients., Journal of Translational Medicine, 2014, p204- Journal Article, 2014 DOI TARA - Full Text

Niamh E Mangan, Nollaig Bourke, Caroline Gargett, Paul J. Hertzog, 125, Cytokine, 70, (1), 2014, p58 Journal Article, 2014

Dowling, J.K., Becker, C.E., Bourke, N.M., (...), Mansell, A., O'Neill, L.A.J., Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation, Journal of Biological Chemistry, 289, (10), 2014, p6429-6437 Journal Article, 2014 TARA - Full Text DOI

Niamh E. Mangan, Nollaig Bourke, Ka Yee Fung, Sebastian Stifter, Caroline Gargett, Paul J. Hertzog, 175, Cytokine, 63, (3), 2013, p284 Journal Article, 2013

Stevenson NJ, Bourke NM, Ryan EJ, Binder M, Fanning L, Johnston JA, Hegarty JE, Long A, O'Farrelly C, Hepatitis C Virus targets the Interferon-" JAK/STAT pathway by promoting proteasomal degradation in immune cells and hepatocytes., FEBS letters, 587, (10), 2013, p1571-1578 Journal Article, 2013 DOI TARA - Full Text

Leonie Unterholzner, Rebecca P. Sumner, Marcin Baran, Hongwei Ren, Daniel S. Mansur, Nollaig M. Bourke, Felix Randow, Geoffrey L. Smith, Andrew G. Bowie, Vaccinia Virus Protein C6 Is a Virulence Factor that Binds TBK-1 Adaptor Proteins and Inhibits Activation of IRF3 and IRF7, PLoS Pathogens, 7, (9, e1002247), 2011 Journal Article, 2011 TARA - Full Text

Stevenson NJ, Murphy AG, Bourke NB, Keogh CA, Hegarty JE, O'Farrelly C, Ribavirin Enhances IFN-α Signalling and MxA Expression: A Novel Immune Modulation Mechanism during Treatment of HCV, PLoS One, 6, (11), 2011, pe27866 Journal Article, 2011 TARA - Full Text

Liam Townsend, Adam H Dyer, Karen Jones, Jean Dunne, Rachel Kiersey, Fiona Gaffney, Laura O'Connor, Aoife Mooney, Deirdre Leavy, Katie Ridge, Catherine King, Fionnuala Cox, Kate O'Brien, Joanne Dowds, Jamie Sugrue, David Hopkins, Patricia Byrne, Tara Kingston, Cliona Ni Cheallaigh, Parthiban Nadarajan, Anne Marie McLaughlin, Nollaig M Bourke, Colm Bergin, Cliona O'Farrelly, Ciaran Bannan, Niall Conlon, Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection Journal Article,

Research Expertise


Age related diseases; AGE-RELATED-CHANGES; AGEING; Angiogenesis, oncology, cardiovascular biology, inflammation; Biomarkers of disease; BLOODBORNE VIRUSES; CELLULAR IMMUNE-RESPONSE; CHRONIC INFLAMMATION; CYTOKINE GENES; Cytokine modulation of immune responses; Cytokine signalling; Disease Prevention; GENE REGULATION; GENE-EXPRESSION; GENOMICS; HEPATITIS-C VIRUS; Hormones; HUMAN IMMUNODEFICIENCY VIRUS (HIV); Immune system; Infectious Diseases; Inflammation; Molecular basis to inflammation and innate immunity; REPRODUCTIVE HORMONES; TYPE I INTERFERONS; VIRUS INFECTION; VIRUS-INFECTED PATIENTS



Society for Mucosal Immunology 2016

Irish Society of Immunology 2008

International Cytokine and Interferon Society (ICIS) 2014

Victorian Infection and Immunity Network, Australia 2012

Australian Centre for HIV and Hepatitis Virology Research (ACH2) 2013 – 2015