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Dr. Nollaig Bourke
Ussher Assistant Professor, Medical Gerontology

Publications and Further Research Outputs

Peer-Reviewed Publications

Townsend L, Dowds J, O'Brien K, Sheill G, Dyer AH, O'Kelly B, Hynes JP, Mooney A, Dunne J, Ni Cheallaigh C, O'Farrelly C, Bourke NM, Conlon N, Martin-Loeches I, Bergin C, Nadarajan P, Bannan C., Persistent Poor Health Post-COVID-19 Is Not Associated with Respiratory Complications or Initial Disease Severity., Annals of the American Thoracic Society, 2021 Journal Article, 2021 DOI

Batten I, Robinson MW, White A, Walsh C, Fazekas B, Wyse J, Buettner A, D'Arcy S, Greenan E, Murphy CC, Wigston Z, Gabhann-Dromgoole JN, Vital EM, Little MA, Bourke NM., Investigation of type I interferon responses in ANCA-associated vasculitis., Scientific reports, 11, (1), 2021, p8272 Journal Article, 2021 DOI

Townsend L, Fogarty H, Dyer A, Martin-Loeches I, Bannan C, Nadarajan P, Bergin C, O' Farrelly C, Conlon N, Bourke NM, Ward SE, Byrne M, Ryan K, O' Donnell JS, Prolonged elevation of D-dimer Levels in Convalescent COVID-19 patients is Independent of the Acute Phase Response., Journal of thrombosis and haemostasis : JTH, 2021 Journal Article, 2021

Dyer A, McKenna L, Gamage G, Bourke N, Killane I, Widdowson M, Woods C, Gibney J, Reilly R, O'Neill D, Kennelly S. , Cognitive performance in midlife type 2 diabetes: results from the ENBIND study, Diabetic Medicine, 2020 Journal Article, 2020 URL DOI

Liam Townsend, Adam H Dyer, Karen Jones, Jean Dunne, Rachel Kiersey, Fiona Gaffney, Laura O'Connor, Aoife Mooney, Deirdre Leavy, Katie Ridge, Catherine King, Fionnuala Cox, Kate O'Brien, Joanne Dowds, Jamie Sugrue, David Hopkins, Patricia Byrne, Tara Kingston, Cliona Ni Cheallaigh, Parthiban Nadarajan, Anne Marie McLaughlin, Nollaig M Bourke, Colm Bergin, Cliona O'Farrelly, Ciaran Bannan, Niall Conlon, Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection, PloS One, 2020 Journal Article, 2020

Liam Townsend, Adam H Dyer, Aifric Naughton, Rachel Kiersey, Dean Holden, Mary Gardiner, Joanne Dowds, Kate O'Brien, Ciaran Bannan, Parthiban Nadarajan, Jean Dunne, Ignacio Martin-Loeches, Padraic Fallon, Colm Bergin, Cliona O'Farrelly, Cliona Ni Cheallaigh, Nollaig Bourke, Niall Conlon, Longitudinal analysis of COVID-19 patients shows age-associated T cell changes independent of ongoing ill-health, medRxiv, 2020 Journal Article, 2020

Dyer AH, McKenna L, Batten I, Jones K, Widdowson M, Dunne J, Conlon N, Reilly R, Woods CP, O'Neill D, Gibney J, Bourke NM, Kennelly SP., Peripheral Inflammation and Cognitive Performance in Middle-Aged Adults With and Without Type 2 Diabetes: Results From the ENBIND Study, Front. Aging Neurosci, 12, 2020 Journal Article, 2020 DOI URL

Jennifer K. Dowling, Michelle D. Tate, Sarah Rosli, Nollaig M. Bourke, Natalie Bitto, Mario A. Lauterbach, Shane Cheung, Thomas Ve, Bostjan Kobe, Douglas Golenbock, Ashley Mansell, The Single Nucleotide Polymorphism Mal-D96N Mice Provide New Insights into Functionality of Mal in TLR Immune Responses, The Journal of Immunology, 2019, pji1800501 Journal Article, 2019

Marks ZRC, Campbell N, deWeerd NA, Lim SS, Gearing LJ, Bourke NM, Hertzog PJ., PROPERTIES AND FUNCTIONS OF THE NOVEL TYPE I INTERFERON EPSILON., Seminars in immunology, 2019, p101328 Journal Article, 2019 DOI

Layte, R. and McCrory, C., Ni Cheallaigh, C., Bourke, N., Kivimaki, M., Ribeiro, A.I, Stringhini, S. and Vineis, P., A Comparative Analysis of the Status Anxiety Hypothesis of Socio-Economic Inequalities in Health Based on 18,349 individuals in Four Countries and Five Cohort Studies, Scientific Reports, Online, 2019, p1 - 6 Journal Article, 2019 URL

Adam Dyer, Isabella Batten, Isabelle Killane, Conor Woods, James Gibney, Desmond O'Neill, Richard Reilly, Nollaig Bourke, Sean Kennelly, 85 Linking Diabetes and Dementia Risk: A Role for Aß-42 Induced Activation of the NLRP3 Inflammasome? Results from the ENBIND Study, 48, (Supplement{\_), 2019, ppiii17--iii65 Published Abstract, 2019

Cathal McCrory, Giovanni Fiorito, Sinead McLoughlin, Silvia Polidoro, Cliona Ni Cheallaigh, Nollaig Bourke, Piia Karisola, Harri Alenius, Paolo Vineis, Richard Layte, Rose Anne Kenny, Epigenetic clocks and allostatic load reveal potential sex-specific drivers of biological ageing, Journal of Gerontology: Biological Sciences, 2019 Journal Article, 2019

Adam Dyer, Isabelle Killane, Nollaig Bourke, Conor Woods, James Gibney, Desmond O'Neill, Richard Reilly, Sean Kennelly, 84 Does Dual-Task Gait Speed Predict Cognitive Performance in Midlife Type 2 Diabetes? Baseline Results from the ENBIND Study, 48, (Supplement{\_), 2019, ppiii1--iii16 Published Abstract, 2019

Bourke NM, Napoletano S, Bannan C, Ahmed S, Bergin C, McKnight à , Stevenson NJ., Control of HIV infection by IFN-alpha: implications for latency and a cure., Cellular and molecular life sciences : CMLS, 75, (5), 2018, p775-783 Journal Article, 2018 DOI TARA - Full Text

Cumming HE, Bourke NM, Type I IFNs in the female reproductive tract: The first line of defense in an ever-changing battleground., Journal of leukocyte biology, 2018 Journal Article, 2018

Nollaig M Bourke, Sharon L Achilles, Stephanie U Huang, Helen E Cumming, Irene Papageorgio, Linden J Gearing, Suruchi Thakore, Niamh E Mangan, Sam Mesiano, Paul J Hertzog, Human IFN": Spaciotemporal expression, hormone regulation and innate immunity in the female reproductive tract, 2018 Journal Article, 2018

de Weerd NA, Matthews AY, Pattie PR, Bourke NM, Lim SS, Vivian JP, Rossjohn J, Hertzog PJ., A hot spot on interferon α/β receptor subunit 1 (IFNAR1) underpins its interaction with interferon-β and dictates signaling., The Journal of Biological Chemistry, 292, (18), 2017, p7554 - 7565 Journal Article, 2017 TARA - Full Text DOI

Mahony R, Gargan S, Roberts KL, Bourke N, Keating SE, Bowie AG, O'Farrelly C, Stevenson NJ, A novel anti-viral role for STAT3 in IFN-alpha signalling responses. , Cellular and Molecular Life Sciences, 74, (9), 2017, p1755 - 1764 Journal Article, 2017 TARA - Full Text DOI

Klionsky et al, Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)., Autophagy, 12, (1), 2016, p1 - 122 Journal Article, 2016 DOI

New Interferons in, editor(s)Michael J. H. Ratcliffe , Encyclopedia of Immunobiology, Elsevier, 2016, pp501 - 508, [Paul J. Hertzog, Nollaig M. Bourke, Nicole A. de Weerd, Niamh E. Mangan] Book Chapter, 2016

Bourke NM, O'Neill M, Sarwar S, Norris S, Stewart S, Hegarty JE, Stevenson NJ and O'Farrelly C., In vitro Blood Cell Responsiveness to IFN-alpha Predicts Clinical Response Independently of IL28B in Hepatitis C Virus Genotype 1 Infected Patients., Journal of Translational Medicine, 2014, p204- Journal Article, 2014 TARA - Full Text DOI

Dowling, J.K., Becker, C.E., Bourke, N.M., (...), Mansell, A., O'Neill, L.A.J., Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation, Journal of Biological Chemistry, 289, (10), 2014, p6429-6437 Journal Article, 2014 TARA - Full Text DOI

Niamh E Mangan, Nollaig Bourke, Caroline Gargett, Paul J. Hertzog, 125, 70, (1), 2014, pp58 Published Abstract, 2014

Stevenson NJ, Bourke NM, Ryan EJ, Binder M, Fanning L, Johnston JA, Hegarty JE, Long A, O'Farrelly C, Hepatitis C Virus targets the Interferon-" JAK/STAT pathway by promoting proteasomal degradation in immune cells and hepatocytes., FEBS letters, 587, (10), 2013, p1571-1578 Journal Article, 2013 DOI TARA - Full Text

Niamh E. Mangan, Nollaig Bourke, Ka Yee Fung, Sebastian Stifter, Caroline Gargett, Paul J. Hertzog, 175, 63, (3), 2013, pp284 Published Abstract, 2013

Leonie Unterholzner, Rebecca P. Sumner, Marcin Baran, Hongwei Ren, Daniel S. Mansur, Nollaig M. Bourke, Felix Randow, Geoffrey L. Smith, Andrew G. Bowie, Vaccinia Virus Protein C6 Is a Virulence Factor that Binds TBK-1 Adaptor Proteins and Inhibits Activation of IRF3 and IRF7, PLoS Pathogens, 7, (9, e1002247), 2011 Journal Article, 2011 TARA - Full Text

Stevenson NJ, Murphy AG, Bourke NB, Keogh CA, Hegarty JE, O'Farrelly C, Ribavirin Enhances IFN-α Signalling and MxA Expression: A Novel Immune Modulation Mechanism during Treatment of HCV, PLoS One, 6, (11), 2011, pe27866 Journal Article, 2011 TARA - Full Text

Non-Peer-Reviewed Publications

Ann Monaghan, Nollaig Bourke, Aisling O'Halloran, Mark Ward, Feng Xue, Glenn Jennings, Rose Anne Kenny and Roman Romero-Ortuno, New self-reported exhaustion during the COVID-19 Pandemic, TILDA Report, 2021 Report, 2021 TARA - Full Text DOI

De Looze, C., Ward, M., McDowell, C., Bourke, N., Kenny R.A., Preparing for COVID-19 vaccination: important learnings from the Irish Longitudinal Study on Ageing (TILDA), Dublin, TILDA, December, 2020 Report, 2020 URL TARA - Full Text DOI

Research Expertise

Description

My research focuses on understanding how the immune system changes with age and the role immune dysregulation plays in age-related disease initiation and pathology. In particular, I am interested in investigating how the initiation and regulation of innate immune responses, such as inflammation and anti-viral immunity, change with age, with a focus on how these processed are related to biological ageing and age-associated physiological decline.

Keywords

Age related diseases; AGE-RELATED-CHANGES; AGEING; Angiogenesis, oncology, cardiovascular biology, inflammation; Biomarkers of disease; BLOODBORNE VIRUSES; CELLULAR IMMUNE-RESPONSE; CHRONIC INFLAMMATION; CYTOKINE GENES; Cytokine modulation of immune responses; Cytokine signalling; Disease Prevention; GENE REGULATION; GENE-EXPRESSION; GENOMICS; HEPATITIS-C VIRUS; Hormones; HUMAN IMMUNODEFICIENCY VIRUS (HIV); Immune system; Infectious Diseases; Inflammation; Molecular basis to inflammation and innate immunity; REPRODUCTIVE HORMONES; TYPE I INTERFERONS; VIRUS INFECTION; VIRUS-INFECTED PATIENTS

Recognition

Memberships

Society for Mucosal Immunology 2016 – 2018

Irish Society of Immunology 2008

International Cytokine and Interferon Society (ICIS) 2014

Victorian Infection and Immunity Network, Australia 2012 – 2017

Australian Centre for HIV and Hepatitis Virology Research (ACH2) 2013 – 2015