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Dr. Bahman Nasseroleslami
Assistant Professor, Clinical Medicine

Biography

Bahman Nasseroleslami received the B.Sc. degree in mechanical engineering from Iran University of Science and Technology, Tehran, Iran, in 2003, and the M.Sc. degree in biomechanical engineering from Sharif University of Technology, Tehran, Iran, in 2006. He received his Ph.D. degree in biomedical engineering from University of Strathclyde, Glasgow, Scotland, UK, in 2013. He was with the Department of Biology, Northeastern University, Boston, MA, USA, as a Research Associate (2012) and a Postdoctoral Research Associate (2013-2014). He joined Academic Unit of Neurology in Trinity College Dublin, the University of Dublin, Dublin, Ireland as a Research Fellow in 2014, and then worked a Senior Research Fellow. He is currently the Fr Tony Coote Assistant Professor in Neuroelectric Signal Analysis in MND, a Principal Investigator, and the Research Strand Leader of the neural signal analysis and neurophysiological biomarkers in the Motor Neuron Disease research group at Trinity College Dublin. His research area includes neural control of human movement, EEG/EMG and electrophysiological correlates of neuro-motor activity, diagnostic and prognostic biomarkers in Motor Neuron Disease (MND), and neural engineering. He has received more than €900,000 competitive research funding as Principal Investigator from Irish Research Council (IRC), Health Research Board (HRB) and Research Motor Neurone (RMN) of Ireland; Amyotrophic Lateral Sclerosis Association (ALSA), and more than €1,200,000 as co-investigator or collaborator. He is the author of 19 articles (5 as the first author, 8 as the last author) in international peer-reviewed journals. Dr Nasseroleslami is a member of IEEE, IEEE EMBS, Society for Neuroscience (SfN), International Society of Electrophysiology & Kinesiology (ISEK), Organisation for Human Brain Mapping (OHBM), Federation of European Neuroscience Societies (FENS) and Neuroscience Ireland. He was a recipient of a 3-year Ph.D. scholarship award from Scottish Funding Council (SFC) in 2008 and Government of Ireland 2-year Postdoctoral Research Fellowship from IRC in 2015. His research paper in Journal of Biomechanical Engineering was selected as an editors' choice paper in 2014.

Publications and Further Research Outputs

Peer-Reviewed Publications

McMackin R, Dukic S, Costello E, Pinto-Grau M, Fasano A, Buxo T, Heverin M, Reilly R, Muthuraman M, Pender N, Hardiman O, Nasseroleslami B., Localization of Brain Networks Engaged by the Sustained Attention to Response Task Provides Quantitative Markers of Executive Impairment in Amyotrophic Lateral Sclerosis., Cerebral cortex (New York, N.Y. : 1991), 2020 Journal Article, 2020 DOI

Dukic S, McMackin R, Buxo T, Fasano A, Chipika R, Pinto-Grau M, Costello E, Schuster C, Hammond M, Heverin M, Coffey A, Broderick M, Iyer PM, Mohr K, Gavin B, Pender N, Bede P, Muthuraman M, Lalor EC, Hardiman O, Nasseroleslami B., Patterned functional network disruption in amyotrophic lateral sclerosis. , Human Brain Mapping, 40, (16), 2019, p4827 - 4842 Journal Article, 2019 URL

Amir Bahador Farjadian, Mohsen Nabian, Amber Hartman, Sheng-Che Yen, Bahman Nasseroleslami, Visuomotor Control of Ankle Joint using Position vs. Force, European Journal of Neuroscience, 50, (8), 2019, p3235 - 3250 Journal Article, 2019

McMackin R, Muthuraman M, Groppa S, Babiloni C, Taylor JP, Kiernan MC, Nasseroleslami B, Hardiman O., Measuring network disruption in neurodegenerative diseases: New approaches using signal analysis., Journal of neurology, neurosurgery, and psychiatry, 90, (9), 2019, p1011 - 1020 Journal Article, 2019 DOI TARA - Full Text

McMackin R, Dukic S, Broderick M, Iyer PM, Pinto-Grau M, Mohr K, Chipika R, Coffey A, Buxo T, Schuster C, Gavin B, Heverin M, Bede P, Pender N, Nasseroleslami B, Dysfunction of attention switching networks in amyotrophic lateral sclerosis., NeuroImage: Clinical, 22, 2019, p101707 Journal Article, 2019

Roisin McMackin, Peter Bede, Niall Pender, Orla Hardiman, Bahman Nasseroleslami, Neurophysiological markers of network dysfunction in neurodegenerative diseases, NeuroImage: Clinical, 22, 2019, p101706 Journal Article, 2019

Nasseroleslami B, Dukic S, Broderick M, Mohr K, Schuster C, Gavin B, McLaughlin R, Heverin M, Vajda A, Iyer PM, Pender N, Bede P, Lalor EC, Hardiman O., Characteristic Increases in EEG Connectivity Correlate With Changes of Structural MRI in Amyotrophic Lateral Sclerosis., Cereb Cortex, 29, (1), 2019, p27 - 41 Journal Article, 2019

Frontiers in Aging Neuroscience, Frontiers Media SA, [Review Editor], 2018 Editorial Board, 2018

Frontiers in Neurology, Switzerland, Frontiers Media SA, [Review Editor], 2017 Editorial Board, 2017

Iyer PM, Mohr K, Broderick M, Gavin B, Burke T, Bede P, Pinto-Grau M, Pender NP, McLaughlin R, Vajda A, Heverin M, Lalor EC, Hardiman O, Nasseroleslami B, Mismatch Negativity as an Indicator of Cognitive Sub-Domain Dysfunction in Amyotrophic Lateral Sclerosis, Frontiers in Neurology, 8, 2017, p395- Journal Article, 2017 TARA - Full Text

Dukic S., Iyer P. M., Mohr K., Hardiman O., Lalor E. C., Nasseroleslami B., Estimation of coherence using the median is robust against EEG artefacts , 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) , Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) , Jeju, South Korea, 2017, 2017, pp3949 - 3952 Conference Paper, 2017 DOI

Frontiers in Human Neuroscience, Switzerland, Frontiers Media SA, [Review Editor], 2016 Editorial Board, 2016

Iyer PM, Egan C, Pinto-Grau M, Burke T, Elamin M, Nasseroleslami B, Pender N, Lalor EC, Hardiman O, Functional Connectivity Changes in Resting-State EEG as Potential Biomarker for Amyotrophic Lateral Sclerosis., PloS one, 10, (6), 2015, pe0128682 Journal Article, 2015 URL

A. Vuckovic, M.A. Hasan, B. Osuagwu, M. Fraser, D.B. Allan, B.A. Conway, B. Nasseroleslami, The Influence of Central Neuropathic Pain in Paraplegic Patients on Performance of a Motor Imagery Based Brain Computer Interface, Clinical Neurophysiology, 126, (11), 2015, p2170 - 2180 Journal Article, 2015 DOI URL TARA - Full Text

Nasseroleslami, B., Sternad, D., Extrinsic contributions to movement variability in human object manipulation, 2014-December, 2014 Conference Paper, 2014

Vuckovic A, Hasan MA, Fraser M, Conway BA, Nasseroleslami B, Allan DB, Dynamic oscillatory signatures of central neuropathic pain in spinal cord injury., The journal of pain : official journal of the American Pain Society, 15, (6), 2014, p645-55 Journal Article, 2014

Ye, F., Nasseroleslami, B., Sternad, D., Predictability in human manipulation of nonlinear dynamic objects, 2014-December, 2014 Conference Paper, 2014

Nasseroleslami B, Vossoughi G, Boroushaki M, Parnianpour M, Simulation of movement in three-dimensional musculoskeletal human lumbar spine using directional encoding-based neurocontrollers., Journal of biomechanical engineering, 136, (9), 2014, p091010 Journal Article, 2014

Nasseroleslami B, Hasson CJ, Sternad D, Rhythmic Manipulation of Objects with Complex Dynamics: Predictability over Chaos., PLoS computational biology, 10, (10), 2014, pe1003900 Journal Article, 2014

Xu R, Jiang N, Vuckovic A, Hasan M, Mrachacz-Kersting N, Allan D, Fraser M, Nasseroleslami B, Conway B, Dremstrup K, Farina D, Movement-related cortical potentials in paraplegic patients: abnormal patterns and considerations for BCI-rehabilitation., Frontiers in neuroengineering, 7, 2014, p35 Journal Article, 2014 DOI TARA - Full Text

Nasseroleslami B, Lakany H, Conway BA, EEG signatures of arm isometric exertions in preparation, planning and execution., NeuroImage, 90, 2014, p1-14 Journal Article, 2014 DOI

Nasseroleslami, B., Hasson, C. J., Sternad, D., Chaos as source of variability in a discrete manipulation task, 43, 2013 Published Abstract, 2013

Nasseroleslami, Bahman, Lakany, Heba, Conway, Bernard A., IEEE, EEG Event-Related Potentials in Preparation, Planning and Execution of Arm Isometric Exertions, Localized by Surface Laplacian, 2013, pp761-764 Conference Paper, 2013

Nasseroleslami, B., Lakany, H., Conway, B.A., EEG event-related potentials in preparation, planning and execution of arm isometric exertions, localized by surface Laplacian, 2013, pp761-764 Conference Paper, 2013

Nasseroleslami, B., Hasson, C. J., Sternad, D., Dynamic predictability in the manipulation of complex objects, 42, 2012 Published Abstract, 2012

Hasson, C. J., Nasseroleslami, B., Krakauer, J. W., Sternad, D., Comparing haptic and visual feedback control of an object with complex dynamics, 42, 2012 Published Abstract, 2012

Nasseroleslami, B., Lakany, H., Conway, B.A., Identification of time-frequency EEG features modulated by force direction in arm isometric exertions, 2011, pp422-425 Conference Paper, 2011

Nasseroleslami, B., Lakany, H., Conway, B.A., Event-related (de-)synchronisation in arm isometric exertions: A wavelet analysis, 2011, pp164-170 Conference Paper, 2011

Sedighi, A., Sadati, N., Nasseroleslami, B., Vakilzadeh, M.K., Narimani, R., Parnianpour, M., Control of human spine in repetitive sagittal plane flexion and extension motion using a CPG based ANN approach., 2011, 2011, pp8146-8149 Conference Paper, 2011

Vuckovic, A., Hasan, M.A., Nasseroleslami, B., Conway, B.A., Allan, D.B., Fraser, M., Motor imagery in spinal cord injury with neuropathic pain: A component clustering method, 2011 Conference Paper, 2011

Rashedi E, Khalaf K, Nassajian MR, Nasseroleslami B, Parnianpour M, How does the central nervous system address the kinetic redundancy in the lumbar spine? Three-dimensional isometric exertions with 18 Hill-model-based muscle fascicles at the L4-L5 level., Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine, 224, (3), 2010, p487-501 Journal Article, 2010

E. Rashedi*, S.J. Mousavi, M. Nassajian, B. Nasseroleslami, M. Parnianpour, , Theoretical Study of Possible Solutions for Addressing the Kinetic Redundancy in Lumbar Spine by Central Nervous System, Journal of Research in Rehabilitation Science (Medical University of Isfahan), 4, (2), 2008, p79 - 92 Journal Article, 2008

M. H. Sadeghi, S. Jafari*, B. Nasseroleslami*, Modal Analysis of a Turbo Pump Shaft: An Innovative Suspending Method to Improve the Results, IUST International Journal of Engineering Science, 19, (5-1), 2008, p143 - 149 Journal Article, 2008

B. Nasseroleslami, S.J. Mousavi, and M. Parnianpour*, Co-contraction in Biomechanical Models, Journal of Research in Rehabilitation Science (Medical University of Isfahan), 3, (1), 2007, p5 - 10 Journal Article, 2007

Non-Peer-Reviewed Publications

Bahman Nasseroleslami, Quantifying the cognitive-behavioural impairment in ALS/ALS-FTD in terms of network dysfunction using neuro-electric (EEG) signals and data analytics, 2019 Meeting of the ALS-FTD Research Network, Dublin, Ireland, 28 June 2019, 2019 Invited Talk, 2019

Nasseroleslami, Bahman and Dukic, Stefan and Bista, Saroj and Buxo, Teresa and Coffey, Amina and McMackin, Roisin and Muthuraman, Muthuraman and Hardiman, Orla and Lalor, Edmund C. and Lowery, Madeleine M., Non-Parametric Rank Statistics for Spectral Power and Coherence, bioRxiv, 2019, p818906 Journal Article, 2019 DOI

Bahman Nasseroleslami, An Implementation of Empirical Bayesian Inference and Non-Null Bootstrapping for Threshold Selection and Power Estimation in Multiple and Single Statistical Testing, 2019 Journal Article, 2019

Bahman Nasseroleslami, Neuroelectric Biomarkers of Network Dysfunction in Motor Neuron Disease, Sheffield, UK, 27 June 2019, 2019 Invited Talk, 2019

Kieran Mohr, Bahman Nasseroleslami, Parameswaran Mahadeva Iyer, Orla Hardiman, Edmund C. Lalor, EyeBallGUI: A Tool For Visual Inspection And Binary Marking of Multi-Channel Bio-Signals, biorxiv, 2017 Journal Article, 2017

Research Expertise

Description

Specific: The contribution of motor sub-systems to neural control of human movement in health and disease ; General: - Diagnosis in Neuromotor Dysfunction and Motor Neuron Disease (MND) - Neural Control of Human Movement - Human Motor Neurophysiology and Pathophysiology - EEG, EMG and Electrophysiological Correlates of Neuro-Motor Activity - Neural and Rehabilitation Engineering - Computational Modelling of Motor Control and Learning - Neuromuscular Biomechanics - Neural Signal Processing and Statistics

Projects

  • Title
    • Impairments of Neuro-muscular Communication in Motor-Neuron Disease: A Bio-Marker for Early and Personalised Diagnosis
  • Funding Agency
    • Irish Research Council
  • Date From
    • 2015
  • Date To
    • 2017
  • Title
    • Novel biomarkers of ALS subphenotypes using advanced imaging and spectral EEG technology
  • Summary
    • Amyotrophic Laterals Sclerosis (ALS) is a progressive neurodegenerative disease of unknown origin. There is a well-established link between ALS and frontotemporal executive dysfunction (FTD). There is a recognized need to develop reliable biomarkers that both reflect disease categories, and that are informative for disease onset progression and survival. Our previously published large longitudinal population based cohort study has shown that ALS can be categorized into subgroups based on cognitive status and that these subgroups have different disease trajectories. The main hypothesis of this proposal is that a combination of high resolution structural and dynamic imaging of the brain at 3 Tesla, coupled with spectral EEG analysis and detailed neuropsychological assessment can be utilized to subphenotype ALS into different cohorts; and that the imaging and neurophysiologic correlates may also be suitable for development as early biomarkers of progressive cognitive decline in ALS. Spectral EEG is a promising technology in neurodegeneration, and a useful biomarker of progressive alterations in functional connectivity in Alzheimer's Disease and FTD . An argument for the development of EEG based approaches in ALS is the recognition of extensive and progressive break-down in intrahemispheric connectivity as evidenced by resting state fMRI studies and consistent corpus callosum involvement in ALS regardless of genotypes. Assessing network integrity of the same patient cohort with both MRI and EEG serves as a powerful validation tool. This methodology will also be developed for individual level evaluation, and to quantify the risk for developing the disease in at risk groups. This will be of utility in future studies of asymptomatic family members particularly with the advent of effective disease modifying therapies.
  • Funding Agency
    • Health Research Board, HRB - Health Research Charities Ireland, HRCI (Research Motor Neurone, RMN)
  • Date From
    • 1/11/2018
  • Date To
    • 30/11/2021
  • Title
    • Discovery of Novel Phenotypes of Amyotrophic Lateral Sclerosis based on Neurophysiological Measures of Network Dysfunction for Patient Stratification in Clinical Trials
  • Funding Agency
    • Amyotrophic Lateral Sclerosis Association (US)
  • Date From
    • 1/1/2020
  • Date To
    • 31/12/2022
  • Title
    • Novel Non-invasive Assessment of the Spinal Cord Electrical Activity for Neurological Diagnosis (Non-invasive Electrical Imaging of the Spinal Cord for Neurological Diagnosis)
  • Funding Agency
    • Trinity College Dublin, the University of Dublin
  • Date From
    • 1/9/2020
  • Date To
    • 31/8/2020
  • Title
    • Finding neurophysiological Biomarkers of cognitive network dysfunction across neurodegenerative diseases: differential diagnostics, novel re-phenotyping, and clinical trial design
  • Funding Agency
    • , Irish Research Council (IRC)/Research Motor Neurone (RMN)
  • Date From
    • 1/4/2020
  • Date To
    • 31/3/2024
  • Title
    • Novel Diagnostic Method for Assessing Cortical Connectivity of Motor Units in Amyotrophic Lateral Sclerosis
  • Funding Agency
    • Irish Research Council (IRC)/Research Motor Neurone (RMN)
  • Date From
    • 1/4/2020
  • Date To
    • 31/3/2022
  • Title
    • Development of Novel Non-invasive Biomarkers in Spinal Muscular Atrophy
  • Funding Agency
    • Irish Institute of Clinical Neuroscience
  • Date From
    • 2019
  • Date To
    • 2020
  • Title
    • Network Impairment in ALS: Quantifying the Unquantifiable
  • Funding Agency
    • Fondation Thierry Latran (France)
  • Date From
    • 2019
  • Date To
    • 2022
  • Title
    • Pin-Pointing the Weakest Link in Network Collapse in Amyotrophic Lateral Sclerosis: Multi-Modal Neurophysiological Biomarkers of Disrupted Cortical Connections for Patient Selection and Intervention
  • Funding Agency
    • Irish Research Council
  • Date From
    • 1/9/2019
  • Date To
    • 31/8/2023
  • Title
    • Neurophysiological Biomarkers for Comparative Diagnosis and Prognosis across Neurodegenerative Diseases
  • Funding Agency
    • Royal Society (UK)
  • Date From
    • 2019
  • Date To
    • 2021
  • Title
    • Mathematical Solutions for Mapping Structured Time-Series: Inference of Brain Neurophysiology Using Electroencephalography
  • Funding Agency
    • Trinity College Dublin, the University of Dublin
  • Date From
    • 1/9/2020
  • Date To
    • 31/8/2024
  • Title
    • A Multidisciplinary Study of Cognition in Multiple Sclerosis
  • Funding Agency
    • Merck Pharmaceuticals and Science Foundation Ireland (FutureNeuro SFI Centre)
  • Date From
    • 2018
  • Date To
    • 2022
  • Title
    • Project ALS-Electrode: Neuro-electrical Biomarkers of Network Degeneration in ALS
  • Funding Agency
    • Stichting ALS Nederland
  • Date From
    • 2018
  • Date To
    • 2021

Keywords

Amyotrophic Lateral Sclerosis / Motor Neurone Disease; Biomechanics of human movement; Biomechanics, Biomedical Engineering; Biomedical Engineering; EEG; ELECTROMYOGRAPHY (EMG); MOTOR CONTROL; Neural Control of Human Movement; NEUROPHYSIOLOGY

Recognition

Representations

Member of Editorial Board and Review Editor: Frontiers in Human Neuroscience (3/2016 - present) 2016-present

Member of Editorial Board and Review Editor: Movement Disorders, Frontiers in Neurology (11/2017 - present) 2017-presnet

Member of Editorial Board and Review Editor: Frontiers in Aging Neuroscience (10/2018 - present) 2018-present

Co-Chair, Motor Control Abstract Session 4, XXV Congress of the International Society of Biomechanics, Glasgow, Scotland, UK, 2015. 2015

Awards and Honours

Government of Ireland Postdoctoral Research Fellowship (2 years), Irish Research Council. 2015-2017

2nd Prize for Oral Presentation, Postdoctoral Research Day of Trinity Biomedical Sciences Institute, Trinity College Dublin, the University of Dublin, Dublin, Dublin, Ireland 2016

Dean's Awards for Innovation in Teaching, Faculty of Health Sciences, Trinity College Dublin, the University of Dublin, Dublin, Ireland 2015

1st Prize for Poster Presentation, Postdoctoral Research Day of Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland 2015

Editors' Choice Paper 2014, Journal of Biomechanical Engineering (DOI:10.1115/1.4027664) 2014

PhD Scholarship Award, Scottish Funding Council (SFC) 2008-2011

Memberships

IEEE 2010 – 2020

IEEE EMBS 2010 – 2020

Society for Neuroscience (SfN) 2010 – 2020

International Society of Electrophysiology & Kinesiology (ISEK) 2015 – 2021

Federation of European Neuroscience Societies (FENS)/Neuroscience Ireland 2014 – 2020

Organisation for Human Brain Mapping 2016 – 2020