Biography
Professor Lawler graduated from the Genetics Department, Trinity College Dublin (TCD) (1985). He is Associate Professor in Experimental Haematology/ Oncology, TCD, Chief Molecular Geneticist at St James's Hospital, Honorary Associate Professor in Oncogenetics, Smurfit Institute of Genetics, TCD and Visiting Professor in Medical Genetics and Molecular Medicine, University of Chieti, Italy. He has an active research group working on the molecular basis of cancer, with emphasis on translating this knowledge to biomarker discovery and novel anti-cancer approaches. He has published over 100 articles in international peer review journals. He has been honoured with numerous awards including the Vander Molen Prize for Leukaemia Research, the Ely Lilly Prize, the Ulster Cancer Foundation Prize and he has received both the St Lukes Medal and the Graves Medal for research. He is currently President of the Irish Association for Cancer Research, an all Ireland association for cancer researchers. He is a member of the Ireland/Northern Ireland/ National Cancer Institute Cancer Consortium Scientific Advisory Group and has recently been appointed as Chair of the Scholar Exchange Group. He is a founder member and one of the coordinators of the MSc in Molecular Medicine, TCD. He is founder and Chairperson of the highly successful Cancer Conference which has now become an annual event on the calendar. Professor Lawler was recently Director of Post-graduate Teaching and Learning in the School of Medicine, Trinity College Dublin and has a significant commitment to scholar exchange. He also is firmly committed to outreach and has participated in a number of community initiatives including "Your Health is your Wealth" and "Wise up! Its your life too!". He is married to Ruth and they have two daughters, Sarah and Emily.
Publications and Further Research Outputs
Peer-Reviewed Publications
Lysaght J, Verma NK, Maginn EN, Ryan JM, Campiani G, Zisterer DM, Williams DC, Browne PV, Lawler MP, McElligott AM, The microtubule targeting agent PBOX-15 inhibits integrin-mediated cell adhesion and induces apoptosis in acute lymphoblastic leukaemia cells., International journal of oncology, 42, (1), 2013, p239-46
Maginn EN, Browne PV, Hayden P, Vandenberghe E, McDonagh B, Evans P, Goodyer M, Tewari P, Campiani G, Butini S, Williams DC, Zisterer DM, Lawler MP, McElligott AM., PBOX-15, a novel microtubule targeting agent, induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple myeloma cells., British Journal of Cancer, 104, (2), 2011, p281 - 289
Greene LM, Nathwani SM, Bright SA, Fayne D, Croke A, Gargliardi M, Mc Elligott AM, O'Connor L, Carr M, Keely NO, O'Boyle NM, Carroll P, Sarkadi B, Conneally E, Lloyd DG, Lawler M, Meegan MJ, Zisterer DM, The vascular targeting agent Combretastatin-A4 and a novel cis-restricted {beta}-lactam analogue CA-432 induce apoptosis in human chronic myeloid leukemia cells and in ex vivo patient samples including those displaying multidrug resistance., The Journal of Pharmacology and Experimental Therapeutics, 335, (2), 2010, p302 - 313
Sandra A. Bright, Giuseppe Campiani, Michael W. Deininger, Mark Lawler, D. Clive Williams and Daniela M. Zisterer, Sequential treatment with flavopiridol synergistically enhances pyrrolo-1,5-benzoxazepine-induced apoptosis in human chronic myeloid leukaemia cells including those resistant to imatinib treatment , Biochemical Pharmacology, 80, 2010, p31 - 38
Nathwani, S-M., Butler, S., Meegan, M.J., Campiani, G., Lawler, M., Williams, D.C. & Zisterer, D.M., Dual targeting of tumour cells and host endothelial cells by novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines., Cancer Chemotherapy and Pharmacology, 65, (2), 2010, p289-300
Seema-Maria Nathwani , Suzanne M. Cloonan, Maeve Stronach, Giuseppe Campiani, Mark Lawler, D. Clive Williams and Daniela M. Zisterer, Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce cell cycle arrest and apoptosis in prostate cancer cells. , Oncology Reports, 24, 2010, p1499 - 1507
Bright S.A., Greene, L.M., Greene, T.F., Campiani, G., Buitini, S., Brindisi, M., Lawler, M., Meegan, M.J., Williams, D.C. and Zisterer, D.M. , The novel pyrrolo-1,5-benzoxazepine, PBOX-21, potentiates the apoptotic efficacy of STI571 (imatinib mesylate) in human chronic myeloid leukaemia cells, Biochemical Pharmacology, 77, (3), 2009, p310-321
Lynn Martin, Brian Marples, Mary Coffey, Mark Lawler, Donal Hollywood, Laure Marignol, Recognition of O6MeG lesions by MGMT and mismatch repair proficiency may be a prerequisite for low-dose radiation hypersensitivity., Radiation Research, 172, (4), 2009, p405 - 413
Veale EB, Frimannsson DO, Lawler M, Gunnlaugsson T, 4-Amino-1,8-naphthalimide based Tröger's bases as high affinity DNA targeting fluorescent supramolecular scaffolds, Organic Letters, 11, (18), 2009, p4040-4043
Marignol, L., Foley, R., Southgate, T.D., Coffey, M., Hollywood, D., Lawler, M., Hypoxia response element-driven cytosine deaminase/5-fluorocytosine gene therapy system: a highly effective approach to overcome the dynamics of tumour hypoxia and enhance the radiosensitivity of prostate cancer cells in vitro., The Journal of Gene Medicine , 11, (2), 2009, p169-179
Ryan J, Quinn F, Meunier A, Boublikova L, Crampe M, Tewari P, O'Marcaigh A, Stallings R, Neat M, O'Meara A, Breatnach F, McCann S, Browne P, Smith O, Lawler M., Minimal residual disease detection in childhood acute lymphoblastic leukaemia patients at multiple time-points reveals high levels of concordance between molecular and immunophenotypic approaches., British Journal of Haematology, 144, (1), 2009, p107-115
Foley R, Marignol L, Thomas AZ, Cullen IM, Perry AS, Tewari P, O'Grady A, Kay E, Dunne B, Loftus B, Watson WR, Fitzpatrick JM, Woodson K, Lehman T, Hollywood D, Lynch TH, Lawler M, The HIF-1alpha C1772T polymorphism may be associated with susceptibility to clinically localised prostate cancer but not with elevated expression of hypoxic biomarkers., Cancer biology & therapy, 8, (2), 2009, p118-24
Murphy TM, Perry AS, Lawler M., The emergence of DNA methylation as a key modulator of aberrant cell death in prostate cancer., Endocrine-Related Cancer , 15, (1 ), 2008, p11-25
Verma NK, Dempsey E, Conroy J, Olwell P, Mcelligott AM, Davies AM, Kelleher D, Butini S, Campiani G, Williams DC, Zisterer DM, Lawler M, Volkov Y., A new microtubule-targeting compound PBOX-15 inhibits T-cell migration via post-translational modifications of tubulin., Journal of Molecular Medicine, 86, (4), 2008, p457-469
Greene, LM, Campiani, GC, Lawler, M, Williams, DC and Zisterer, DM, BubR1 is Required for a Sustained Mitotic Spindle checkpoint arrest in Human Cancer cells treated with a tubulin-targetting pyrrolo-1,5-benzoxazepine, Molecular Pharmacology, 73, (2), 2008, p419 - 430
Marignol L, Coffey M, Lawler M, Hollywood D., Hypoxia in prostate cancer: a powerful shield against tumour destruction?, Cancer Treatment Reviews, 34, (4), 2008, p313-327
Marignol L, Robson T, McCarthy HO, Worthington J, Murray MM, Hollywood D, Lawler M, Hirst DG., The tissue plasminogen activator gene promoter: a novel tool for radiogenic gene therapy of the prostate?, Journal of Gene Medicine, 10, (9), 2008, p1032-1038
Hayden PJ, Tewari P, Morris DW, Staines A, Crowley D, Nieters A, Becker N, de Sanjosé S, Foretova L, Maynadié M, Cocco PL, Boffetta P, Brennan P, Chanock SJ, Browne PV, Lawler M., Variation in DNA repair genes XRCC3, XRCC4, XRCC5 and susceptibility to myeloma., Human Molecular Genetics, 16, (24), 2007, p3117-3127
Greene LM, Kelly L, Onnis V, Campiani G, Lawler M, Williams DC, Zisterer DM., STI-571 (imatinib mesylate) enhances the apoptotic efficacy of pyrrolo-1,5-benzoxazepine-6, a novel microtubule-targeting agent, in both STI-571-sensitive and -resistant Bcr-Abl-positive human chronic myeloid leukemia cells., Journal of Pharmacology and Experimental Therapeutics, 321, (1), 2007, p288-297
Perry AS, Liyanage H, Lawler M, Woodson K., Discovery of DNA hypermethylation using a DHPLC screening strategy., Epigenetics, 2, (1), 2007, p43-49
Langabeer SE, Ni Ainle F, Conneally E, Lawler M., Incidence and significance of the JAK2 V617F mutation in patients with chronic myeloproliferative disorders., Irish Journal of Medical Science, 176, (2), 2007, p105-109
Saldanha J, Silvy M, Beaufils N, Arlinghaus R, Barbany G, Branford S, Cayuela JM, Cazzaniga G, Gonzalez M, Grimwade D, Kairisto V, Miyamura K, Lawler M, Lion T, Macintyre E, Mahon FX, Muller MC, Ostergaard M, Pfeifer H, Saglio G, Sawyers C, Spinelli O, van der Velden VH, Wang JQ, Zoi K, Patel V, Phillips P, Matejtschuk P, Gabert J., Characterization of a reference material for BCR-ABL (M-BCR) mRNA quantitation by real-time amplification assays: towards new standards for gene expression measurements., Leukemia, 21, (7), 2007, p1481-1487
Marignol L, Coffey M, Hollywood D, Lawler M., Radiation to Control Transgene Expression in Tumors., Cancer Biological Therapy, 6, (7), 2007, p1005 - 1012
Perry AS, Loftus B, Moroose R, Lynch TH, Hollywood D, Watson RW, Woodson K, Lawler M., In silico mining identifies IGFBP3 as a novel target of methylation in prostate cancer., British Journal of Cancer, 96, (10), 2007, p1587-1594
McCann S, Passweg J, Bacigalupo A, Locasciulli A, Locatelli F, Ryan J, Schrezenmeier H, Lawler M., The influence of cyclosporin alone, or cyclosporin and methotrexate, on the incidence of mixed haematopoietic chimaerism following allogeneic sibling bone marrow transplantation for severe aplastic anaemia., Bone Marrow Transplant., 39, (2), 2007, p109-114
Perry, A.S., Foley, R., Woodson, K., Lawler, M., The emerging roles of DNA methylation in the clinical management of prostate cancer , Endocrine-Related Cancer, 13, (2), 2006, p357-377
Boublikova L, Kalinova M, Ryan J, Quinn F, O'Marcaigh A, Smith O, Browne P, Stary J, McCann SR, Trka J, Lawler M., Wilms' tumor gene 1 (WT1) expression in childhood acute lymphoblastic leukemia: a wide range of WT1 expression levels, its impact on prognosis and minimal residual disease monitoring, Leukemia, 20, (2), 2006, p254 - 263
Boublikova L, Kalinova M, Ryan J, Quinn F, O'Marcaigh A, Smith O, Browne P, Stary J, McCann SR, Trka J, Lawler M., Wilms' tumor gene 1 (WT1) expression in childhood acute lymphoblastic leukemia: a wide range of WT1 expression levels, its impact on prognosis and minimal residual disease monitoring., Leukemia., 20, (2), 2006, p254-263
Mulligan JM, Greene LM, Cloonan S, Mc Gee MM, Onnis V, Campiani G, Fattorusso C, Lawler MP, Williams C, Zisterer DM., Identification of tubulin as the molecular target of pro-apoptotic pyrrolo-1,5-benzoxazepines., Molecular Pharmacology, 70, (1), 2006, p60-70
O'Donghaile D, Hayden PJ, McCarron SL, Doyle EM, Lawler M, Browne PV, Conneally E, Vandenberghe E, McCann SR., Marrow aplasia developing 13 years after HLA-identical sibling allogeneic transplantation for chronic myeloid leukaemia: successful treatment with antithymocyte globulin and peripheral blood stem cell infusion from the original donor., European Journal of Haematology, 76, (3), 2006, p258-260
Hayat A, O'Brien D, O'Rourke P, McGuckin S, Fitzgerald T, Conneally E, Browne PV, McCann SR, Lawler MP, Vandenberghe E., CD38 expression level and pattern of expression remains a reliable and robust marker of progressive disease in chronic lymphocytic leukemia., Leukemia Lymphoma, 47, (11), 2006, p2371-2379
McCann SR, Crampe M, Molloy K, Lawler M. , Hemopoietic chimerism following stem cell transplantation., Transfus Apheresis Sci. , 32, (1), 2005, p55-61.
Tracey L, Pérez-Rosado A, Artiga MJ, Camacho FI, Rodríguez A, Martínez N, Ruiz-Ballesteros E, Mollejo M, Martinez B, Cuadros M, Garcia JF, Lawler M, Piris MA, The expression of the NF-kB targets BCL2 and BIRC5/Survivin characterize small B-cell and aggressive B-cell lymphomas respectively, Journal of Pathology, 206, (2), 2005, p123-134
Marignol L, Lawler M, Coffey M, Hollywood D., Achieving Hypoxia-Inducible Gene Expression in Tumors., Cancer Biological Therapy, 4, (4), 2005, p359-364.
Dean J, McCarthy D, Lawler M, Doherty DG, O' Farrelly C, Golden-Mason L., Characterization of NKR(+) T-cell subsets in human bone marrow: implications for immunosurveillance of neoplasia., Clinical Immunology, 114, (1 ), 2005, p42-51
Greene, L.M., Fleeton, M., Mulligan, J., Chikana, G., Sheahan, B.J., Atkins, G.J., Campiani, G., Nacci, V., Lawler, M., Williams, D.C. and Zisterer, D.M., The pyrrolo-1,5-benzoxazepine, PBOX-6, inhibits the growth of breast cancer cells in vitro independent of estrogen receptor status, and inhibits breast tumour growth in vivo, Oncology Reports, 14, 2005, p1357 - 1363
Hayden PJ, Crampe M, Lawler M, Conneally E., McCann SR., Vandenberghe E., Browne PV., Use of DLI to achieve complete donor chimerism in a patient receiving systemic immunosuppression for refractory AIHA post-NST., Bone Marrow Transplant, 36, 2005, p735-736
L. Tracey, I. Spiteri, P. Ortiz, M. Lawler, M. A. Piris and R. Villuendas, Transcriptional response of T cells to IFN-alpha: changes induced in IFN-alpha-sensitive and resistant cutaneous T cell lymphoma, Journal of Interferon & Cytokine Research, 24, (3), 2004, p185-95
P. J. Hayden, N. Gardiner, K. Molloy, J. Ryan, M. Lawler and S. R. McCann, Pure red cell aplasia after a major ABO-mismatched bone marrow transplant for chronic myeloid leukaemia: response to re-introduction of cyclosporin, Bone Marrow Transplantation, 33, (4), 2004, p459-461
Swords R, Hayden PJ, Molloy K, Lawler M, Browne PV, Murphy PT., Successful induction of molecular remission with single-agent anti-CD33 antibody (gemtuzumab ozogamicin) in chemotherapy-refractory relapse of acute myeloid leukaemia post-BMT., European Journal of Haematology, 73, (6), 2004, p450-451
Crean CW, Camier R, Lawler M, Stevenson C, Davies RJ, Boyle PH, Kelly JM., Synthesis of N3- and 2-NH(2)-substituted 6,7-diphenylpterins and their use as intermediates for the preparation of oligonucleotide conjugates designed to target photooxidative damage on single-stranded DNA representing the bcr-abl chimeric gene., Organic and Biomolecular Chemistry, 2, (24), 2004, p3588-3601
Foley, R., Hollywood, D., Lawler, M., Molecular pathology of prostate cancer: The key to identifying new biomarkers of disease , Endocrine-Related Cancer , 11, (3), 2004, p477-488
R. Foley, M. Lawler and D. Hollywood, Gene-based therapy in prostate cancer, Lancet Oncology, 5, (8), 2004, p469-79
Gupta V, Ball SE, Yi QL, Sage D, McCann SR, Lawler M, Ortin M, Freires M, Hale G, Waldmann H, Gordon-Smith EC, Marsh JC., Favorable effect on acute and chronic graft-versus-host disease with cyclophosphamide and in vivo anti-CD52 monoclonal antibodies for marrow transplantation from HLA-identical sibling donors for acquired aplastic anemia., Biology of Blood and Marrow Transplant., 10, (12), 2004, p867-876
M. M. Mc Gee, L. M. Greene, S. Ledwidge, G. Campiani, V. Nacci, M. Lawler, D. C. Williams and D. M. Zisterer, Selective induction of apoptosis by the pyrrolo-1,5-benzoxazepine 7-[[dimethylcarbamoyl]oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine (PBOX-6) in Leukemia cells occurs via the c-Jun NH2-terminal kinase-dependent phosphorylation and inactivation of Bcl-2 and Bcl-XL, The Journal of pharmacology and experimental therapeutics, 310, (3), 2004, p1084-1095
L. Tracey, R. Villuendas, A. M. Dotor, I. Spiteri, P. Ortiz, J. F. Garcia, J. L. Peralto, M. Lawler and M. A. Piris, Mycosis fungoides shows concurrent deregulation of multiple genes involved in the TNF signaling pathway: an expression profile study, Blood, 102, (3), 2003, p1042-1050
S. R. McCann, K. Gately, E. Conneally and M. Lawler, Molecular response to imatinib mesylate following relapse after allogeneic SCT for CML, Blood, 101, (3), 2003, p1200-1
M. Lawler, A. Locasciulli, D. Longoni, R. Schiro and S. R. McCann, Leukaemic transformation of donor cells in a patient receiving a second allogeneic bone marrow transplant for severe aplastic anaemia, Bone Marrow Transplantation, 29, (5), 2002, p453-456
C. W. Cream, Y. T. Kavanagh, C. M. O'Keeffe, M. P. Lawler, C. Stevenson, R. J. Davies, P. H. Boyle and J. M. Kelly, Targeting of photooxidative damage on single-stranded DNA representing the bcr-abl chimeric gene using oligonucleotide-conjugates containing [Ru(phen)3](2+)-like photosensitiser groups, Photochemical & photobiological sciences, 1, (12), 2002, p1024-33
L. A. Mynett-Johnson, C. Keenan, I. L. Black, W. J. Livingstone, M. Lawler, H. M. Roche, B. White, M. J. Gibney, P. McKeon and O. P. Smith, Thermolabile methylenetetrahydrofolate reductase (C677T): frequency in the Irish population, Irish journal of medical science, 171, (1), 2002, p37-9
M. M. Mc Gee, G. Campiani, A. Ramunno, V. Nacci, M. Lawler, D. C. Williams and D. M. Zisterer, Activation of the c-Jun N-terminal kinase (JNK) signaling pathway is essential during PBOX-6-induced apoptosis in chronic myelogenous leukemia (CML) cells, The Journal of Biological Chemistry, 277, (21), 2002, p18383-18389
R. Pawson, M. N. Potter, P. Theocharous, M. Lawler, M. Garg, J. A. Yin, K. Rezvani, C. Craddock, S. Rassam and H. G. Prentice, Treatment of relapse after allogeneic bone marrow transplantation with reduced intensity conditioning (FLAG +/- Ida) and second allogeneic stem cell transplant, British journal of haematology, 115, (3), 2001, p622-9
D. M. Zisterer, M. M. McGee, G. Campiani, A. Ramunno, C. Fattorusso, V. Nacci, M. Lawler and D. C. Williams, Pyrrolo-1,5-benzoxazepines: a new class of apoptotic agents, Biochemical Society transactions, 29, (Pt 6), 2001, p704-6
K. Cwynarski, R. Goulding, C. Pocock, F. Dazzi, C. Craddock, J. Kaeda, E. Olavarria, E. Kanfer, J. Apperley, M. Lawler and J. M. Goldman, Immune haemolytic anaemia following T cell-depleted allogeneic bone marrow transplantation for chronic myeloid leukaemia: association with leukaemic relapse and treatment with donor lymphocyte infusions, Bone marrow transplantation, 28, (6), 2001, p581-6
L. Galligan, W. Livingstone, Y. Volkov, K. Hokamp, C. Murphy, M. Lawler, K. Fukudome and O. Smith, Characterization of protein C receptor expression in monocytes, British journal of haematology, 115, (2), 2001, p408-14
M. Lawler, Prospective chimerism analysis, the time is now but can we respond?, Leukemia, 15, (12), 2001, p1992-4
M. M. Mc Gee, G. Campiani, A. Ramunno, C. Fattorusso, V. Nacci, M. Lawler, D. C. Williams and D. M. Zisterer, Pyrrolo-1,5-benzoxazepines induce apoptosis in chronic myeloid leukemia (cml) cells by bypassing the apoptotic suppressor bcr-abl, TheScientificWorldJournal [electronic resource], 1, (1 Suppl 3), 2001, p109
D. M. Zisterer, M. M. McGee, G. Campiani, A. Ramunno, C. Fattorusso, V. Nacci, M. Lawler and D. C. Williams, Pyrrolo-1,5-benzoxazepines: a new class of apoptotic agents, Biochemical Society transactions, 29, (6), 2001, p704-706
M. M. Mc Gee, G. Campiani, A. Ramunno, C. Fattorusso, V. Nacci, M. Lawler, D. C. Williams and D. M. Zisterer, Pyrrolo-1,5-benzoxazepines induce apoptosis in chronic myelogenous leukemia (CML) cells by bypassing the apoptotic suppressor bcr-abl, The Journal of Pharmacology and Experimental Therapeutics, 296, (1), 2001, p31-40
M. M. Mc Gee, G. Campiani, A. Ramunno, C. Fattorusso, V. Nacci, M. Lawler, D. C. Williams and D. M. Zisterer, Pyrrolo-1,5-benzoxazepines induce apoptosis in chronic myelogenous leukemia (CML) cells by bypassing the apoptotic suppressor bcr-abl, The Journal of pharmacology and experimental therapeutics, 296, (1), 2001, p31-40
B. White, M. Schmidt, C. Murphy, W. Livingstone, D. O'Toole, M. Lawler, L. O'Neill, D. Kelleher, H. P. Schwarz and O. P. Smith, Activated protein C inhibits lipopolysaccharide-induced nuclear translocation of nuclear factor kappaB (NF-kappaB) and tumour necrosis factor alpha (TNF-alpha) production in the THP-1 monocytic cell line, British journal of haematology, 110, (1), 2000, p130-4
M. Schmidt-Supprian, C. Murphy, B. While, M. Lawler, A. Kapurniotu, W. Voelter, O. Smith and J. Bernhagen, Activated protein C inhibits tumor necrosis factor and macrophage migration inhibitory factor production in monocytes, European cytokine network, 11, (3), 2000, p407-13
C. Craddock, P. Bardy, S. Kreiter, R. Johnston, J. Apperley, D. Marks, C. Huber, K. Kolbe, R. Goulding, M. Lawler, J. Goldman, T. Hughes and G. Derigs, Short Report: Engraftment of T-cell-depleted allogeneic haematopoietic stem cells using a reduced intensity conditioning regimen, British journal of haematology, 111, (3), 2000, p797-800
C. Keenan, W. J. Livingstone, B. White, L. Mynett-Johnson, S. Cusack, M. Lawler and O. P. Smith, Prevalence of the prothrombin G20210A mutation in the Irish populations: use of a novel polymerase chain reaction approach, Blood coagulation & fibrinolysis, 11, (7), 2000, p669-72
W. J. Livingstone, C. Keenan, B. White, L. Mynett-Johnson, M. Lawler, P. Mayne and O. P. Smith, Prevalence of the factor VR506Q mutation in two Irish control populations: use of a novel nested polymerase chain reaction approach, British journal of haematology, 111, (2), 2000, p559-61
M. Lawler, Molecular Medicine and Molecular Pathology for Haematologists: I. Gene Speak made Easy: An Overview of Genes and Gene Expression, Hematol, 4, (1), 1999, p59-66
M. O'Donovan, J. M. Russell, J. J. O'Leary, J. A. Gillan, M. P. Lawler and E. F. Gaffney, Abl expression, tumour grade, and apoptosis in chondrosarcoma, Molecular pathology, 52, (6), 1999, p341-4
N. Gardiner, S. R. McCann, J. O'Riordan and M. Lawler, Chimerism following donor lymphocyte infusion for chronic myeloid leukemia, Blood, 93, (8), 1999, p2748-9
M. Lawler, Molecular Medicine and Molecular Pathology for Hematologists: II. Lets go Techno; Principles of the Molecular Technologies and their Applications in Haematology, Hematol, 4, (2), 1999, p127-135
H. Rozemuller, W. Terpstra, E. J. Rombouts, M. Lawler, C. Byrne, D. J. FitzGerald, R. J. Kreitman, J. J. Wielenga, B. Lowenberg, I. P. Touw, A. Hagenbeek and A. C. Martens, GM-CSF receptor targeted treatment of primary AML in SCID mice using Diphtheria toxin fused to huGM-CSF, Leukemia, 12, (12), 1998, p1962-70
M. Deane, M. Koh, L. Foroni, G. Galactowicz, A. V. Hoffbrand, M. Lawler, L. Secker-Walker and H. G. Prentice, FLAG-idarubicin and allogeneic stem cell transplantation for Ph-positive ALL beyond first remission, Bone marrow transplantation, 22, (12), 1998, p1137-43
H. Gowing, E. Braakman, A. Hagenbeek, M. Lawler, S. R. McCann, D. H. Pamphilon and A. C. Martens, Influence of ultraviolet-B irradiation on engraftment, graft-versus-host disease and graft-versus-leukemia effect in a rat model for allogeneic bone marrow transplantation, Bone marrow transplantation, 21, (8), 1998, p801-7
J. Briones, A. Urbano-Ispizua, M. Lawler, C. Rozman, N. Gardiner, P. Marin, C. Salgado, P. Feliz, S. McCann and E. Montserrat, High frequency of donor chimerism after allogeneic transplantation of CD34+-selected peripheral blood cells, Experimental hematology, 26, (5), 1998, p415-20
N. Gardiner, M. Lawler, J. M. O'Riordan, C. Duggan, M. De Arce and S. R. McCann, Monitoring of lineage-specific chimaerism allows early prediction of response following donor lymphocyte infusions for relapsed chronic myeloid leukaemia, Bone marrow transplantation, 21, (7), 1998, p711-9
M. Lawler, Leukaemogenesis, gene interplay, and the role of the haemopoietic environment, Radiation oncology investigations, 5, (3), 1997, p154-7
N. Gardiner, M. Lawler, J. O'Riordan, M. DeArce, P. Humphries and S. R. McCann, Persistent donor chimaerism is consistent with disease-free survival following BMT for chronic myeloid leukaemia, Bone marrow transplantation, 20, (3), 1997, p235-41
S. Norris, M. Lawler, S. McCann, J. Hegarty and C. O'Farrelly, Donor type microchimerism is an infrequent event following liver transplantation and is not associated with graft acceptance, Hepatology (Baltimore, Md), 26, (4), 1997, p848-52
N. Gardiner, M. Lawler, J. O'Riordan, M. De'Arce and S. R. McCann, Donor chimaerism is a strong indicator of disease free survival following bone marrow transplantation for chronic myeloid leukaemia, Leukemia, 11 Suppl 3, 1997, p512-5
J. Hudson, S. Chown, M. Lawler, C. Duggan, I. J. Temperley and L. Secker-Walker, Severe aplastic anaemia in association with a unique constitutional translocation 46,XY,t(6;10)(q13;q22)c, British journal of haematology, 99, (3), 1997, p520-1
P. Ljungman, M. Lawler, B. Lonnqvist, O. Ringden and A. Shanwell, Rejection of the second allogeneic graft in a patient with severe aplastic anemia reversed by antilymphocyte globulin and donor lymphocyte infusions, Bone marrow transplantation, 18, (6), 1996, p1179-81
P. A. O'Neill, M. Lawler, R. Pullens, T. Kloosterman, J. Hudson, A. C. Martens, P. J. Hendrikx, H. Gowing, C. Byrne, A. Hagenbeek, D. H. Pamphilon and S. R. McCann, PCR amplification of short tandem repeat sequences allows serial studies of chimaerism/engraftment following BMT in rodents, Bone marrow transplantation, 17, (2), 1996, p265-71
D. S. O'Briain, O. Sheils, S. McElwaine, S. R. McCann and M. Lawler, Sorting out mix-ups. The provenance of tissue sections may be confirmed by PCR using microsatellite markers, American journal of clinical pathology, 106, (6), 1996, p758-64
D. Green, M. Lawler, M. Rosen, S. Bloom, M. Duerden, R. Turba, H. Kern, K. Kirschner and D. Ronin, Recombinant human erythropoietin: effect on the functional performance of anemic orthopedic patients, Archives of physical medicine and rehabilitation, 77, (3), 1996, p242-6
K. Molloy, N. Goulden, M. Lawler, J. Cornish, A. Oakhill, D. Pamphilon, M. Potter, C. Steward, K. Langlands, P. Humphries and S. R. McCann, Patterns of hematopoietic chimerism following bone marrow transplantation for childhood acute lymphoblastic leukemia from volunteer unrelated donors, Blood, 87, (7), 1996, p3027-31
P. Kelly, H. Staunton, M. Lawler, P. Brennan, S. Jennings, E. R. Unger, J. H. Sung and M. A. Farrell, Multifocal remitting-relapsing cerebral demyelination twenty years following allogeneic bone marrow transplantation, Journal of neuropathology and experimental neurology, 55, (9), 1996, p992-8
K. M. O'Boyle and M. Lawler, D2 receptor agonists and partial agonists: relationship between receptor binding measures and functional activity, Biochemical Society transactions, 24, (1), 1996, p183-8
M. Hamblin, J. C. Marsh, M. Lawler, S. R. McCann, N. Wickham, L. Dunlop, S. Ball, E. G. Davies, G. Hale, H. Waldmann and E. C. Gordon-Smith, Campath-1G in vivo confers a low incidence of graft-versus-host disease associated with a high incidence of mixed chimaerism after bone marrow transplantation for severe aplastic anaemia using HLA-identical sibling donors, Bone marrow transplantation, 17, (5), 1996, p819-24
G. Socie, M. Lawler, E. Gluckman, S. R. McCann and O. Brison, Studies on hemopoietic chimerism following allogeneic bone marrow transplantation in the molecular biology era, Leukemia research, 19, (8), 1995, p497-504
R. Kumar-Singh, D. G. Bradley, G. J. Farrar, M. Lawler, S. A. Jordan and P. Humphries, Autosomal dominant retinitis pigmentosa: a new multi-allelic marker (D3S621) genetically linked to the disease locus (RP4), Human genetics, 96, (4), 1995, p502
P. Ljungman, M. Lawler, B. Asjo, G. Bogdanovic, K. Karlsson, C. Malm, S. R. McCann, O. Ringden and G. Gahrton, Infection of donor lymphocytes with human T lymphotrophic virus type 1 (HTLV-I) following allogeneic bone marrow transplantation for HTLV-I positive adult T-cell leukaemia, British journal of haematology, 88, (2), 1994, p403-5
S. R. Mc Cann, M. Lawler, N. Gardiner, J. O'Riordan, P. Humphries and M. De Arce, Donor leukemia following allogeneic bone marrow transplantation, Leukemia, 8 Suppl 1, 1994, pS133-5
N. J. Philpott, J. C. Marsh, T. O. Kumaran, A. Yardumian, M. Lawler, S. R. McCann and E. C. Gordon-Smith, Successful bone marrow transplant for Fanconi anaemia in transformation, Bone marrow transplantation, 14, (1), 1994, p151-3
J. G. Hudson, M. Lawler and D. H. Pamphilon, Ultraviolet irradiation for the prevention of graft-versus-host disease and graft rejection in bone marrow transplantation, Bone marrow transplantation, 14, (4), 1994, p511-6
M. Lawler, P. Humphries, C. O'Farrelly, H. Hoey, O. Sheils, M. Jeffers, D. S. O'Briain and D. Kelleher, Adenovirus 12 E1A gene detection by polymerase chain reaction in both the normal and coeliac duodenum, Gut, 35, (9), 1994, p1226-32
S. R. McCann and M. Lawler, Mixed chimaerism; detection and significance following BMT, Bone marrow transplantation, 11, (2), 1993, p91-4
S. R. McCann, M. Lawler and A. Bacigalupo, Recurrence of Philadelphia chromosome-positive leukemia in donor cells after bone marrow transplantation for chronic granulocytic leukemia, Leukemia & lymphoma, 10, (6), 1993, p419-25
D. H. Pamphilon, J. M. Cornish, S. Goodman, L. Ball, M. Lawler, S. McCann, P. Humphries and A. Oakhill, Successful second unrelated donor BMT in a child with juvenile chronic myeloid leukaemia: documentation of chimaerism using the polymerase chain reaction, Bone marrow transplantation, 11, (1), 1993, p81-4
E. L. Blundell, D. H. Pamphilon, N. A. Anderson, R. R. Slade, P. A. Burton, A. Martin, T. Ray, B. A. Bradley, M. Lawler, P. Humphries and et al., Transfusion-associated graft-versus-host disease, monoclonal gammopathy and PCR, British journal of haematology, 82, (3), 1992, p622-3
S. R. McCann, M. Lawler, P. Humphries, A. Bacigalupo, M. Podesta, F. Frassoni, M. T. Van Lint and A. Marmont, Recurrence of Philadelphia chromosome-positive leukemia in donor cells after marrow transplantation for chronic granulocytic leukemia: confirmation by microsatellite studies, Blood, 79, (10), 1992, p2803-5
M. A. De Arce, C. Costigan, J. R. Gosden, M. Lawler and P. Humphries, Further evidence consistent with Yqh as an indicator of risk of gonadal blastoma in Y-bearing mosaic Turner syndrome, Clinical genetics, 41, (1), 1992, p28-32
R. Kumar-Singh, D. G. Bradley, G. J. Farrar, M. Lawler, S. A. Jordan and P. Humphries, Autosomal dominant retinitis pigmentosa: a new multi-allelic marker (D3S621) genetically linked to the disease locus (RP4), Human genetics, 86, (5), 1991, p502-4
M. Lawler, P. Humphries and S. R. McCann, Evaluation of mixed chimerism by in vitro amplification of dinucleotide repeat sequences using the polymerase chain reaction, Blood, 77, (11), 1991, p2504-14
P. V. Browne, M. Lawler, P. Humphries and S. R. McCann, Donor-cell leukemia after bone marrow transplantation for severe aplastic anemia, The New England journal of medicine, 325, (10), 1991, p710-3
P. V. Browne, M. Lawler, J. O'Riordan, P. Humphries and S. R. McCann, Early detection of leukaemic relapse after bone marrow transplantation using the polymerase chain reaction, Bone marrow transplantation, 7, (2), 1991, p167-9
P. Browne, M. Lawler and S. R. McCann, Donor cell leukaemia after bone marrow transplantation for severe aplastic anaemia, Bone marrow transplantation, 7 Suppl 2, 1991, p100
S. R. McCann, M. Lawler and P. Humphries, Mixed chimaerism, British journal of haematology, 77, (2), 1991, p257
M. M. Humphries, D. Sheils, M. Lawler, G. J. Farrar, P. McWilliam, P. Kenna, D. G. Bradley, E. M. Sharp, E. F. Gaffney, M. Young and et al., Epidermolysis bullosa: evidence for linkage to genetic markers on chromosome 1 in a family with the autosomal dominant simplex form, Genomics, 7, (3), 1990, p377-81
G. J. Farrar, P. McWilliam, D. G. Bradley, P. Kenna, M. Lawler, E. M. Sharp, M. M. Humphries, H. Eiberg, P. M. Conneally, J. A. Trofatter and et al., Autosomal dominant retinitis pigmentosa: linkage to rhodopsin and evidence for genetic heterogeneity, Genomics, 8, (1), 1990, p35-40
M. A. De Arce, D. Mulherin, P. McWilliam, M. Lawler, M. X. FitzGerald and P. Humphries, Frequency of deletion 508 among Irish cystic fibrosis patients, Human genetics, 85, (4), 1990, p403-4
P. McWilliam, G. J. Farrar, P. Kenna, D. G. Bradley, M. M. Humphries, E. M. Sharp, D. J. McConnell, M. Lawler, D. Sheils, C. Ryan and et al., Autosomal dominant retinitis pigmentosa (ADRP): localization of an ADRP gene to the long arm of chromosome 3, Genomics, 5, (3), 1989, p619-22
M. Lawler, S. R. McCann, E. Conneally and P. Humphries, Chimaerism following allogeneic bone marrow transplantation: detection of residual host cells using the polymerase chain reaction, British journal of haematology, 73, (2), 1989, p205-10
Research Expertise
Description
Molecular and cellular biology of cancer; Apoptosis and cancer. Cell cycle control and its manipulation in malignancy. Cellular and molecular mechanisms regulating and resisting apoptosis. Novel pro-apoptotic drug development; Genetics of B cell malignancies; Understanding DNA repair processes in Multiple Myeloma; Chimeric status and outcome following stem cell transplantation for severe aplastic anaemia: Chimerism and minimal residual disease in haematological malignancy. Study of molecular response to Imatinib Mesylate in patients relapsing following stem cell transplantation for Chronic Myeloid Leukaemia. Naphthalimides as novel anti cancer agents; Molecular basis of prostate cancer. Epigenetic control of gene transcription; hypoxia and prostate cancer; suicide gene therapy approaches in prostate cancer; molecular diagnosticsRecognition
Representations
Member, DMMC Cancer Principal Investigators, Trans-institutional grouping of Principal Investigators leading research on Cancer themes
Member, Core Technology PI's, DMMC Principal Investigators leading the development of core technology platforms.
Chairperson, Centre for Molecular Research in Cancer (Proposed), This consortium combines researchers with common interest in understanding cell cycle signaling and regulation with specific focus on two key cancer-related processes (cell cycle control, apoptosis) and/or three specific malignancy types (oesophageal, prostate and haematological).
Chairperson, Prostate Cancer Research Consortium, Multi-centred consortium focused on the development of new diagnostic, prognostic and therapeutic agents for application in prostate cancer.
Copy, Imaging Focus Group Meeting, 1-Day meeting on Biomedical Imaging - 8th June 2004 run in conjunction with TCINFrom single cell & molecular through to organ & whole body
Member, Cycle 2 PI's & Researchers, All Cycle 2 Researchers & PI's
Member, PHG Funded PI's and Researchers, All Researchers funded under Cycle 3 PRTLI - Programme for Human Genomics
Awards and Honours
FRCPath on the basis of published work Royal College of Pathologists, London
44th Annual Graves Medal Lecture Health Research Board and Royal Academy of Medicine in Ireland
.7th Annual Ulster Cancer Foundation Award Lecture
MRCPath on the basis of published worksRoyal College of Pathologists London
22nd Annual St Lukes Medal Lecture St Lukes Institute and Royal Academy of Medicine in Ireland
Ely Lilly Prize European Blood and Marrow Transplant Conference Garmisch Partenkirchen, Germany
Vander Molen Prize for Leukaemia Research British Society of Haematology