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Mark Cunningham
Professor of Neurophysiology of Epilepsy, Physiology

Publications and Further Research Outputs

Peer-Reviewed Publications

Sánchez RG, Parrish RR, Rich M, Webb WM, Lockhart RM, Nakao K, Ianov L, Buckingham SC, Broadwater DR, Jenkins A, de Lanerolle NC, Cunningham M, Eid T, Riley K, Lubin FD., Human and rodent temporal lobe epilepsy is characterized by changes in O-GlcNAc homeostasis that can be reversed to dampen epileptiform activity., Neurobiology of disease, 124, 2019, p531-543 Journal Article, 2019 DOI

Chan F, Lax NZ, Voss CM, Aldana BI, Whyte S, Jenkins A, Nicholson C, Nichols S, Tilley E, Powell Z, Waagepetersen HS, Davies CH, Turnbull DM, Cunningham MO, The role of astrocytes in seizure generation: insights from a novel in vitro seizure model based on mitochondrial dysfunction, Brain, 142, (2), 2019, p391 - 411 Journal Article, 2019 URL

Ramezani R, Liu Y, Dehkhoda F, Soltan A, Haci D, Zhao H, Firfilionis D, Hazra A, Cunningham MO, Jackson A, Constandinou TG, Degenaar P, On-Probe Neural Interface ASIC for Combined Electrical Recording and Optogenetic Stimulation., IEEE transactions on biomedical circuits and systems, 2018 Journal Article, 2018

Hall SP, Traub RD, Adams NE, Cunningham MO, Schofield I, Jenkins AJ, Whittington MA, Enhanced interlaminar excitation or reduced superficial layer inhibition in neocortex generates different spike-and-wave-like electrographic events in vitro., Journal of neurophysiology, 2018 Journal Article, 2018

Simpson AJ, Cunningham MO, Baker MR, Electrodiagnostic applications of somatosensory evoked high-frequency EEG oscillations: Technical considerations., Brain research bulletin, 2018 Journal Article, 2018

Augustin K, Williams S, Cunningham M, Devlin AM, Friedrich M, Jayasekera A, Hussain MA, Holliman D, Mitchell P, Jenkins A, Chen PE, Walker MC, Williams RSB., Perampanel and decanoic acid show synergistic action against AMPA receptors and seizures., Epilepsia, 59, (11), 2018, pe172-e178 Journal Article, 2018 DOI

Stone TJ, Rowell R, Jayasekera BAP, Cunningham MO, Jacques TS, Review: Molecular characteristics of long-term epilepsy-associated tumours (LEATs) and mechanisms for tumour-related epilepsy (TRE)., Neuropathology and applied neurobiology, 2018 Journal Article, 2018

Dheerendra P, Lynch NM, Crutwell J, Cunningham MO, Smulders TV, In vitro characterization of gamma oscillations in the hippocampal formation of the domestic chick., The European journal of neuroscience, 2017 Journal Article, 2017

Serrats J, Cunningham MO, Davies CH, GABAB receptor modulation-to B or not to be B a pro-cognitive medicine?, Current opinion in pharmacology, 2017 Journal Article, 2017

Felix Chan, Nichola Z. Lax, Ceri H. Davies, Douglass M. Turnbull, Mark O. Cunningham, Neuronal oscillations: A physiological correlate for targeting mitochondrial dysfunction in neurodegenerative diseases?, Neuropharmacology, 102, 2016, p48--58 Journal Article, 2016

Ehrmann I, Gazzara MR, Pagliarini V, Dalgliesh C, Kheirollahi-Chadegani M, Xu Y, Cesari E, Danilenko M, Maclennan M, Lowdon K, Vogel T, Elliott DJ, A SLM2 Feedback Pathway Controls Cortical Network Activity and Mouse Behavior., Cell reports, 2016 Journal Article, 2016

Lax NZ, Grady J, Laude A, Chan F, Hepplewhite PD, Gorman G, Whittaker RG, Ng Y, Cunningham MO, Turnbull DM, Extensive respiratory chain defects in inhibitory interneurones in patients with mitochondrial disease., Neuropathology and applied neurobiology, 2016 Journal Article, 2016

Jones RS, da Silva AB, Whittaker RG, Woodhall GL, Cunningham MO, Human brain slices for epilepsy research: Pitfalls, solutions and future challenges., Journal of neuroscience methods, 2016 Journal Article, 2016

Alfonsa H, Merricks EM, Codadu NK, Cunningham MO, Deisseroth K, Racca C, Trevelyan AJ, The contribution of raised intraneuronal chloride to epileptic network activity., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015 Journal Article, 2015

Tsintsadze V, Minlebaev M, Suchkov D, Cunningham MO, Khazipov R, Ontogeny of kainate-induced gamma oscillations in the rat CA3 hippocampus in vitro., Frontiers in cellular neuroscience, 2015 Journal Article, 2015

Tomsett RJ, Ainsworth M, Thiele A, Sanayei M, Chen X, Gieselmann MA, Whittington MA, Cunningham MO, Kaiser M, Virtual Electrode Recording Tool for EXtracellular potentials (VERTEX): comparing multi-electrode recordings from simulated and biological mammalian cortical tissue., Brain structure & function, 2015 Journal Article, 2015

Whittaker RG, Devine HE, Gorman GS, Schaefer AM, Horvath R, Ng Y, Nesbitt V, Lax NZ, McFarland R, Cunningham MO, Taylor RW, Turnbull DM, Epilepsy in adults with mitochondrial disease: A cohort study., Annals of neurology, 2015 Journal Article, 2015

Traub RD, Cunningham MO, Whittington MA, What is a seizure network? Very fast oscillations at the interface between normal and epileptic brain., Advances in experimental medicine and biology, 2014 Journal Article, 2014

Cowie CJ, Cunningham MO, Peritumoral epilepsy: relating form and function for surgical success., Epilepsy & behavior : E&B, 2014 Journal Article, 2014

Simon A, Traub RD, Vladimirov N, Jenkins A, Nicholson C, Whittaker RG, Schofield I, Clowry GJ, Cunningham MO, Whittington MA, Gap junction networks can generate both ripple-like and fast ripple-like oscillations., The European journal of neuroscience, 2014 Journal Article, 2014

Tomsett RJ, Ainsworth M, Thiele A, Sanayei M, Chen X, Gieselmann A, Whittington MA, Cunningham MO, Kaiser M, Modelling local field potential features during network gamma oscillations., BMC neuroscience, 2014 Journal Article, 2014

Tomsett RJ, Ainsworth M, Thiele A, Sanayei M, Chen X, Gieselmann A, Whittington MA, Cunningham MO, Kaiser M, Modelling spatially realistic local field potentials in spiking neural networks using the VERTEX simulation tool., BMC neuroscience, 2014 Journal Article, 2014

Carracedo LM, Kjeldsen H, Cunnington L, Jenkins A, Schofield I, Cunningham MO, Davies CH, Traub RD, Whittington MA, A neocortical delta rhythm facilitates reciprocal interlaminar interactions via nested theta rhythms., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013 Journal Article, 2013

Sedley W, Cunningham MO, Do cortical gamma oscillations promote or suppress perception? An under-asked question with an over-assumed answer., Frontiers in human neuroscience, 2013 Journal Article, 2013

Cunningham MO, Roopun A, Schofield IS, Whittaker RG, Duncan R, Russell A, Jenkins A, Nicholson C, Whittington MA, Traub RD, Glissandi: transient fast electrocorticographic oscillations of steadily increasing frequency, explained by temporally increasing gap junction conductance., Epilepsia, 2012 Journal Article, 2012

Ainsworth M, Lee S, Cunningham MO, Traub RD, Kopell NJ, Whittington MA, Rates and rhythms: a synergistic view of frequency and temporal coding in neuronal networks., Neuron, 2012 Journal Article, 2012

Simonotto JD, Kaiser M, Whittington MA, Cunningham MO, Network properties of control and epileptic human slice recordings., BMC neuroscience, 2011 Journal Article, 2011

Ainsworth M, Lee S, Cunningham MO, Roopun AK, Traub RD, Kopell NJ, Whittington MA, Dual " rhythm generators control interlaminar synchrony in auditory cortex., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011 Journal Article, 2011

Randall FE, Whittington MA, Cunningham MO, Fast oscillatory activity induced by kainate receptor activation in the rat basolateral amygdala in vitro., The European journal of neuroscience, 2011 Journal Article, 2011

Whittington MA, Cunningham MO, LeBeau FE, Racca C, Traub RD, Multiple origins of the cortical " rhythm., Developmental neurobiology, 2011 Journal Article, 2011

Whittaker RG, Turnbull DM, Whittington MA, Cunningham MO, Impaired mitochondrial function abolishes gamma oscillations in the hippocampus through an effect on fast-spiking interneurons., Brain : a journal of neurology, 2011 Journal Article, 2011

Traub RD, Cunningham MO, Whittington MA, Chemical synaptic and gap junctional interactions between principal neurons: partners in epileptogenesis., Neural networks : the official journal of the International Neural Network Society, 2011 Journal Article, 2011

Cunningham MO, Chinnery PF, Mitochondria and cortical gamma oscillations: food for thought?, Brain : a journal of neurology, 2011 Journal Article, 2011

Roopun AK, Simonotto JD, Pierce ML, Jenkins A, Nicholson C, Schofield IS, Whittaker RG, Kaiser M, Whittington MA, Traub RD, Cunningham MO, A nonsynaptic mechanism underlying interictal discharges in human epileptic neocortex., Proceedings of the National Academy of Sciences of the United States of America, 2010 Journal Article, 2010

Roopun AK, Lebeau FE, Rammell J, Cunningham MO, Traub RD, Whittington MA, Cholinergic neuromodulation controls directed temporal communication in neocortex in vitro., Frontiers in Neural Circuits, 2010 Journal Article, 2010

Traub RD, Duncan R, Russell AJ, Baldeweg T, Tu Y, Cunningham MO, Whittington MA, Spatiotemporal patterns of electrocorticographic very fast oscillations (> 80 Hz) consistent with a network model based on electrical coupling between principal neurons., Epilepsia, 2010 Journal Article, 2010

Roopun AK, Traub RD, Baldeweg T, Cunningham MO, Whittaker RG, Trevelyan A, Duncan R, Russell AJ, Whittington MA, Detecting seizure origin using basic, multiscale population dynamic measures: preliminary findings., Epilepsy & behavior : E&B, 2009 Journal Article, 2009

Middleton SJ, Racca C, Cunningham MO, Traub RD, Monyer H, Knöpfel T, Schofield IS, Jenkins A, Whittington MA, High-frequency network oscillations in cerebellar cortex., Neuron, 2008 Journal Article, 2008

Stanger HL, Alford R, Jane DE, Cunningham MO, The role of GLU K5-containing kainate receptors in entorhinal cortex gamma frequency oscillations., Neural Plasticity, 2008 Journal Article, 2008

Roopun AK, Cunningham MO, Racca C, Alter K, Traub RD, Whittington MA, Region-specific changes in gamma and beta2 rhythms in NMDA receptor dysfunction models of schizophrenia., Schizophrenia Bulletin, 2008 Journal Article, 2008

Middleton S, Jalics J, Kispersky T, Lebeau FE, Roopun AK, Kopell NJ, Whittington MA, Cunningham MO, NMDA receptor-dependent switching between different gamma rhythm-generating microcircuits in entorhinal cortex., Proceedings of the National Academy of Sciences of the United States of America, 2008 Journal Article, 2008

Fuchs EC, Zivkovic AR, Cunningham MO, Middleton S, Lebeau FE, Bannerman DM, Rozov A, Whittington MA, Traub RD, Rawlins JN, Monyer H, Recruitment of parvalbumin-positive interneurons determines hippocampal function and associated behavior., Neuron, 2007 Journal Article, 2007

Driver JE, Racca C, Cunningham MO, Towers SK, Davies CH, Whittington MA, LeBeau FE, Impairment of hippocampal gamma-frequency oscillations in vitro in mice overexpressing human amyloid precursor protein (APP)., The European journal of neuroscience, 2007 Journal Article, 2007

Cunningham MO, Pervouchine DD, Racca C, Kopell NJ, Davies CH, Jones RS, Traub RD, Whittington MA, Neuronal metabolism governs cortical network response state., Proceedings of the National Academy of Sciences of the United States of America, 2006 Journal Article, 2006

Pervouchine DD, Netoff TI, Rotstein HG, White JA, Cunningham MO, Whittington MA, Kopell NJ, Low-dimensional maps encoding dynamics in entorhinal cortex and hippocampus., Neural computation, 2006 Journal Article, 2006

Roopun AK, Middleton SJ, Cunningham MO, LeBeau FE, Bibbig A, Whittington MA, Traub RD, A beta2-frequency (20-30 Hz) oscillation in nonsynaptic networks of somatosensory cortex., Proceedings of the National Academy of Sciences of the United States of America, 2006 Journal Article, 2006

Cunningham MO, Hunt J, Middleton S, LeBeau FE, Gillies MJ, Davies CH, Maycox PR, Whittington MA, Racca C, Region-specific reduction in entorhinal gamma oscillations and parvalbumin-immunoreactive neurons in animal models of psychiatric illness., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006 Journal Article, 2006

Traub RD, Bibbig A, LeBeau FE, Cunningham MO, Whittington MA, Persistent gamma oscillations in superficial layers of rat auditory neocortex: experiment and model., The Journal of physiology, 2005 Journal Article, 2005

Traub RD, Contreras D, Cunningham MO, Murray H, LeBeau FE, Roopun A, Bibbig A, Wilent WB, Higley MJ, Whittington MA, Single-column thalamocortical network model exhibiting gamma oscillations, sleep spindles, and epileptogenic bursts., Journal of neurophysiology, 2005 Journal Article, 2005

Cunningham MO, Whittington MA, Bibbig A, Roopun A, LeBeau FE, Vogt A, Monyer H, Buhl EH, Traub RD, A role for fast rhythmic bursting neurons in cortical gamma oscillations in vitro., Proceedings of the National Academy of Sciences of the United States of America, 2004 Journal Article, 2004

Cunningham MO, Halliday DM, Davies CH, Traub RD, Buhl EH, Whittington MA, Coexistence of gamma and high-frequency oscillations in rat medial entorhinal cortex in vitro., The Journal of physiology, 2004 Journal Article, 2004

Cunningham MO, Woodhall GL, Thompson SE, Dooley DJ, Jones RS, Dual effects of gabapentin and pregabalin on glutamate release at rat entorhinal synapses in vitro., The European journal of neuroscience, 2004 Journal Article, 2004

Cunningham MO, Woodhall GL, Jones RS, Valproate modifies spontaneous excitation and inhibition at cortical synapses in vitro., Neuropharmacology, 2003 Journal Article, 2003

Research Expertise

Keywords

Ageing, memory and other cognitive processes; BEHAVIORAL STRESS; Clinical neurology; Consequences of ischemia or hypoxia, convulsive disorders; EEG; ENTORHINAL CORTEX; EPILEPSY; EPILEPSY SURGERY; HIPPOCAMPUS IN-VITRO; INTERNEURONS; MITOCHONDRIA; Neurobiology; Neurochemistry and neuropharmacology; Neurodegeneration; Neurology; Neuropharmacology; Neurophysiology; Neuroscience; OSCILLATIONS; Pathophysiology; Physiology; Psychiatry; TEMPORAL LOBE EPILEPSY

Recognition

Representations

Editorial Board member for Neuropharmacology (Elsevier) 2016

Editorial Board member for Brain Research Bulletins (Elsevier) 2010

Member of Scientific Advisory Committee for Epilepsy Resarch UK 2015

Member of the Biomedical Resource and Technology Development Committee at the Wellcome Trust 2017

Awards and Honours

EMBO Long-term fellowship 2005

RCUK Academic Fellowship 2006

Memberships

Membership of the British Neuroscience Association

Membership of The Physiological Society (UK) 1997 – present

Membership of the International League against Epilepsy (UK Chapter)