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Dr. Micheál Mac Aogáin
Clinical Senior Lecturer, Clinical Medicine

Publications and Further Research Outputs

Peer-Reviewed Publications

Poh TY, Tiew PY, Lim AYH, Thng KX, Binte Mohamed Ali NA, Narayana JK, Mac Aogáin M, Tien Z, Chew WM, Wai Chan AK, Keir HR, Dicker AJ, Hassan TM, Xu H, Tee AKH, Ong TH, Koh MS, Abisheganaden JA, Chalmers JD, Chotirmall SH., Increased Chitotriosidase Is Associated With Aspergillus and Frequent Exacerbations in South-East Asian Patients With Bronchiectasis., Chest, 158, (2), 2020, p512-522 Journal Article, 2020 DOI

Binte Mohamed Ali NA, Ivan FX, Aogáin MM, Narayana JK, Lee SY, Lim CL, Chotirmall SH., THE HEALTHY AIRWAY MYCOBIOME IN INDIVIDUALS OF ASIAN DESCENT., Chest, 2020 Journal Article, 2020 DOI

Tiew PY, Mac Aogain M, Ali NABM, Thng KX, Goh K, Lau KJX, Chotirmall SH., The Mycobiome in Health and Disease: Emerging Concepts, Methodologies and Challenges., Mycopathologia, 185, (2), 2020, p207-231 Journal Article, 2020 DOI

Tiew PY, Ko FWS, Pang SL, Matta SA, Sio YY, Poh ME, Lau KJX, Mac Aogáin M, Jaggi TK, Ivan FX, Gaultier NE, Uchida A, Drautz-Moses DI, Xu H, Koh MS, Hui DSC, Tee A, Abisheganaden JA, Schuster SC, Chew FT, Chotirmall SH., Environmental fungal sensitisation associates with poorer clinical outcomes in COPD., The European respiratory journal, 56, (2), 2020 Journal Article, 2020 DOI

Al Alam D, Danopoulos S, Grubbs B, Ali NABM, MacAogain M, Chotirmall SH, Warburton D, Gaggar A, Ambalavanan N, Lal CV., Human Fetal Lungs Harbor a Microbiome Signature., American journal of respiratory and critical care medicine, 201, (8), 2020, p1002-1006 Journal Article, 2020 DOI

Tiew PY, Ko FWS, Narayana JK, Poh ME, Xu H, Neo HY, Loh LC, Ong CK, Mac Aogáin M, Tan JHY, Kamaruddin NH, Sim GJH, Lapperre TS, Koh MS, Hui DSC, Abisheganaden JA, Tee A, Tsaneva-Atanasova K, Chotirmall SH., "High-Risk" Clinical and Inflammatory Clusters in COPD of Chinese Descent., Chest, 158, (1), 2020, p145-156 Journal Article, 2020 DOI

Al Alam D, Danopoulos S, Grubbs B, Ali NABM, Mac Aogáin M, Chotirmall SH, Warburton D, Gaggar A, Ambalavanan N, Lal CV., Reply to de Steenhuijsen Piters and Bogaert: Bacterial DNA in Fetal Lung Samples May Be Explained by Sample Contamination., American journal of respiratory and critical care medicine, 201, (10), 2020, p1311-1312 Journal Article, 2020 DOI

Mac Aogáin M, Lau KJX, Cai Z, Kumar Narayana J, Purbojati RW, Drautz-Moses DI, Gaultier NE, Jaggi TK, Tiew PY, Ong TH, Siyue Koh M, Lim Yick Hou A, Abisheganaden JA, Tsaneva-Atanasova K, Schuster SC, Chotirmall SH., Metagenomics Reveals a Core Macrolide Resistome Related to Microbiota in Chronic Respiratory Disease., American journal of respiratory and critical care medicine, 202, (3), 2020, p433-447 Journal Article, 2020 DOI

Tiew PY, Dicker AJ, Keir HR, Poh ME, Pang SL, Mac Aogáin M, Chua Qi Yu B, Tan JL, Xu H, Koh MS, Tee A, Abisheganaden JA, Chew FT, Miller BE, Tal-Singer R, Chalmers JD, Chotirmall SH., A high-risk airway mycobiome is associated with frequent exacerbation and mortality in COPD., The European respiratory journal, 2020 Journal Article, 2020 DOI

Palanivel M, Mac Aogáin M, Purbojati RW, Uchida A, Aung NW, Lim SBY, Putra A, Drautz-Moses DI, Seaton S, Rogers TR, Schuster SC, Chotirmall SH., Whole-Genome Sequencing of Aspergillus terreus Species Complex., Mycopathologia, 185, (2), 2020, p405-408 Journal Article, 2020 DOI

Mac Aogáin M, Tiew PY, Lim AYH, Low TB, Tan GL, Hassan T, Ong TH, Pang SL, Lee ZY, Gwee XW, Martinus C, Sio YY, Matta SA, Ong TC, Tiong YS, Wong KN, Narayanan S, Au VB, Marlier D, Keir HR, Tee A, Abisheganaden JA, Koh MS, Wang Y, Connolly JE, Chew FT, Chalmers JD, Chotirmall SH., Distinct "Immunoallertypes" of Disease and High Frequencies of Sensitization in Non-Cystic Fibrosis Bronchiectasis., American journal of respiratory and critical care medicine, 199, (7), 2019, p842-853 Journal Article, 2019 DOI

Gautam S.S, Haug G, Cooley L.A, Mac Aogáin M, O'Toole R.F, Intercontinental translocation of latent multidrug-resistant tuberculosis to Australia demonstrated by whole genome sequencing, Medical Journal of Australia, 210, (5), 2019, p236 - 236.e1 Journal Article, 2019 DOI URL

Mac Aogáin M, Chaturvedi V, Chotirmall SH., MycopathologiaGENOMES: The New 'Home' for the Publication of Fungal Genomes., Mycopathologia, 184, (5), 2019, p551-554 Journal Article, 2019 DOI

Ali NABM, Mac Aogáin M, Morales RF, Tiew PY, Chotirmall SH., Optimisation and Benchmarking of Targeted Amplicon Sequencing for Mycobiome Analysis of Respiratory Specimens., International journal of molecular sciences, 20, (20), 2019 Journal Article, 2019 DOI

Gautam SS, Kc R, Leong KW, Mac Aogáin M, O'Toole RF., A step-by-step beginner's protocol for whole genome sequencing of human bacterial pathogens., Journal of biological methods, 6, (1), 2019, pe110 Journal Article, 2019 DOI

Mac Aogáin M, Chotirmall SH., Bronchiectasis and cough: An old relationship in need of renewed attention., Pulmonary pharmacology & therapeutics, 57, 2019, p101812 Journal Article, 2019 DOI

Lee SY, Mac Aogáin M, Fam KD, Chia KL, Binte Mohamed Ali NA, Yap MMC, Yap EPH, Chotirmall SH, Lim CL., Airway microbiome composition correlates with lung function and arterial stiffness in an age-dependent manner., PloS one, 14, (11), 2019, pe0225636 Journal Article, 2019 DOI

Gautam, S.S. and Aogáin, M.M. and Cooley, L.A. and Haug, G. and Fyfe, J.A. and Globan, M. and O†Toole, R.F., Molecular epidemiology of tuberculosis in Tasmania and genomic characterisation of its first known multi-drug resistant case, PLoS ONE, 13, (2), 2018, p1-- Journal Article, 2018 DOI TARA - Full Text

Yong VFL, Soh MM, Jaggi TK, Mac Aogáin M, Chotirmall SH., The Microbial Endocrinology of Pseudomonas aeruginosa: Inflammatory and Immune Perspectives., Archivum immunologiae et therapiae experimentalis, 66, (5), 2018, p329-339 Journal Article, 2018 DOI

Poh TY, Ali NABM, Mac Aogáin M, Kathawala MH, Setyawati MI, Ng KW, Chotirmall SH., Inhaled nanomaterials and the respiratory microbiome: clinical, immunological and toxicological perspectives., Particle and fibre toxicology, 15, (1), 2018, p46 Journal Article, 2018 DOI

Mac Aogáin M, Chandrasekaran R, Lim AYH, Low TB, Tan GL, Hassan T, Ong TH, Hui Qi Ng A, Bertrand D, Koh JY, Pang SL, Lee ZY, Gwee XW, Martinus C, Sio YY, Matta SA, Chew FT, Keir HR, Connolly JE, Abisheganaden JA, Koh MS, Nagarajan N, Chalmers JD, Chotirmall SH., Immunological corollary of the pulmonary mycobiome in bronchiectasis: the CAMEB study., The European respiratory journal, 52, (1), 2018 Journal Article, 2018 DOI

Lawlor B, Lynch R, Mac Aogáin M, Walsh P., Field of genes: using Apache Kafka as a bioinformatic data repository., GigaScience, 7, (4), 2018 Journal Article, 2018 DOI

Chandrasekaran R, Mac Aogáin M, Chalmers JD, Elborn SJ, Chotirmall SH., Geographic variation in the aetiology, epidemiology and microbiology of bronchiectasis., BMC pulmonary medicine, 18, (1), 2018, p83 Journal Article, 2018 DOI

Ryan L, Golparian D, Fennelly N, Rose L, Walsh P, Lawlor B, Mac Aogáin M, Unemo M, Crowley B., Antimicrobial resistance and molecular epidemiology using whole-genome sequencing of Neisseria gonorrhoeae in Ireland, 2014-2016: focus on extended-spectrum cephalosporins and azithromycin., European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 37, (9), 2018, p1661-1672 Journal Article, 2018 DOI

Gautam SS, Mac Aogáin M, Bower JE, Basu I, O'Toole RF., Differential carriage of virulence-associated loci in the New Zealand Rangipo outbreak strain of Mycobacterium tuberculosis., Infectious diseases (London, England), 49, (9), 2017, p680-688 Journal Article, 2017 DOI

Lynch M, Walsh TA, Marszalowska I, Webb AE, MacAogain M, Rogers TR, Windle H, Kelleher D, O'Connell MJ, Loscher CE., Surface layer proteins from virulent Clostridium difficile ribotypes exhibit signatures of positive selection with consequences for innate immune response., BMC Evolutionary Biology, 17, (1), 2017, p90- Journal Article, 2017 DOI

Lynch M, Walsh TA, Marszalowska I, Webb AE, Mac Aogáin M, Rogers TR, Windle H, Kelleher D, O'Connell MJ, Loscher CE, Erratum to: Surface layer proteins from virulent Clostridium difficile ribotypes exhibit signatures of positive selection with consequences for innate immune response., BMC Evolutionary Biology, 17, (1), 2017, p135- Journal Article, 2017 URL

Gautam, S.S. and Aogáin, M.M. and O'Toole, R.F., Draft genome sequence of the first confirmed isolate of multidrug-resistant Mycobacterium tuberculosis in Tasmania, Genome Announcements, 5, (44), 2017, pe01230-17 Journal Article, 2017 DOI TARA - Full Text

Leung JM, Tiew PY, Mac Aogáin M, Budden KF, Yong VF, Thomas SS, Pethe K, Hansbro PM, Chotirmall SH., The role of acute and chronic respiratory colonization and infections in the pathogenesis of COPD., Respirology (Carlton, Vic.), 22, (4), 2017, p634-650 Journal Article, 2017 DOI

Poh TY, Mac Aogáin M, Chan AK, Yii AC, Yong VF, Tiew PY, Koh MS, Chotirmall SH., Understanding COPD-overlap syndromes., Expert review of respiratory medicine, 11, (4), 2017, p285-298 Journal Article, 2017 DOI

Mac Aogáin M, Fennelly N, Walsh A, Lynagh Y, Bekaert M, Lawlor B, Walsh P , Kelly B, Rogers TR, Crowley B , Fourteen Draft Genome Sequences for the First Reported Cases of Azithromycin-Resistant Neisseria gonorrhoeae in Ireland., Genome Announcements, 5, (23), 2017 Journal Article, 2017

Lynch M, Walsh TA, Marszalowska I, Webb AE, MacAogain M, Rogers TR, Windle H, Kelleher D, O'Connell MJ, Loscher CE., Surface layer proteins from virulent Clostridium difficile ribotypes exhibit signatures of positive selection with consequences for innate immune response., BMC Evolutionary Biology, 17, (1), 2017, p90 - 90 Journal Article, 2017 URL

Chotirmall SH, Gellatly SL, Budden KF, Mac Aogain M, Shukla SD, Wood DL, Hugenholtz P, Pethe K, Hansbro PM., Microbiomes in respiratory health and disease: An Asia-Pacific perspective., Respirology (Carlton, Vic.), 22, (2), 2017, p240-250 Journal Article, 2017 DOI

McElroy MC, Hill M, Moloney G, Mac Aogáin M, McGettrick S, O'Doherty Á, Rogers TR., Typhlocolitis associated with Clostridium difficile ribotypes 078 and 110 in neonatal piglets from a commercial Irish pig herd., Irish Veterinary Journal, 69, (10), 2016 Journal Article, 2016 URL URL

Miche􏰀al Mac Aog􏰀ain, Helen Miajlovic, Geraldine Moloney, Sanjay H. Chotirmall, Thomas R. Rogers and Stephen G. J. Smith, Identification of a novel sequence type of Escherichia coli as the causative agent of pyelonephritis and bloodstream infection, JMM Case Reports, 3, 2016, p1 - 4 Journal Article, 2016 TARA - Full Text DOI URL

Aogáin, M.M. and Gautam, S.S. and Bower, J.E. and Basu, I. and O'Toole, R.F., Draft genome sequence of a New Zealand Rangipo strain of Mycobacterium tuberculosis, Genome Announcements, 4, (4), 2016, pe00657-16 Journal Article, 2016 DOI TARA - Full Text

Moloney G, Mac Aogáin M, Kelleghan M, O'Connell B, Hurley C, Montague E, Conlon M, Murray H, Rogers TR, Possible Interplay Between Hospital and Community Transmission of a Novel Clostridium Difficile Sequence Type 295 Recognized by Next-Generation Sequencing., Infection control and hospital epidemiology, 37, (6), 2016, p680-4 Journal Article, 2016 DOI

Mac Aogáin M, Miajlovic H, Moloney G, Chotirmall SH, Rogers TR, Smith SG., Identification of a novel sequence type of Escherichia coli as the causative agent of pyelonephritis and bloodstream infection., JMM Case Reports, 3, (5), 2016 Journal Article, 2016 URL

Kinnevey PM, Shore AC, Mac Aogáin M, Creamer E, Brennan GI, Humphreys H, Rogers TR, O'Connell B, Coleman DC., Enhanced Tracking of Nosocomial Transmission of Endemic Sequence Type 22 Methicillin-Resistant Staphylococcus aureus Type IV Isolates among Patients and Environmental Sites by Use of Whole-Genome Sequencing., Journal of Clinical Microbiology, 54, (2), 2016, p445 - 448 Journal Article, 2016 URL

Kinnevey PM, Shore AC, Mac Aogáin M, Creamer E, Brennan GI, Humphreys H, Rogers TR, O'Connell B, Coleman DC, Enhanced tracking of the nosocomial transmission of endemic ST22-MRSA-IV among patients and environmental sites using whole-genome sequencing., Journal of clinical microbiology, 2015 Journal Article, 2015

Micheál Mac Aogáin, Geraldine Moloney, Shauna Kilkenny, Mary Kelleher, May Kelleghan, Brieda Boyle, Thomas Rogers, Whole-genome sequencing improves discrimination of relapse from reinfection and identifies transmission events among patients with recurrent Clostridium difficile infections, Journal of Hospital Infection, 2015 Journal Article, 2015

Brown AF, Murphy AG, Lalor SJ, Leech JM, O'Keeffe KM, Mac Aogáin M, O'Halloran DP, Lacey KA, Tavakol M, Hearnden CH, Fitzgerald-Hughes D, Humphreys H, Fennell JP, van Wamel WJ, Foster TJ, Geoghegan JA, Lavelle EC, Rogers TR, McLoughlin RM, Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection., PLoS pathogens, 11, (11), 2015, pe1005226 Journal Article, 2015 DOI TARA - Full Text

Micheál Mac Aogáin. Shauna Kilkenny, Claire Walsh, Sinéad Lindsay, Geraldine Moloney, Trefor Morris, Sophie Jones, Thomas R. Rogers, Identification of a novel mutation at the primary dimer interface of GyrA conferring fluoroquinolone resistance in Clostridium difficile, Journal of Global Antimicrobial Resistance, 2015 Journal Article, 2015 URL TARA - Full Text URL

Miajlovic H, Mac Aogáin M, Collins CJ, Rogers TR, Smith SG, Characterization of Escherichia coli bloodstream isolates associated with mortality., Journal of medical microbiology, 2015 Journal Article, 2015

Yvonne Lynagh, Micheál Mac Aogáin, Thomas Rogers, Magnus Unemo, Brendan Crowley, Detailed characterisation of the first high-level azithromycin-resistant Neisseria gonorrhoeae cases in Ireland, The Journal of Antimicrobial Chemotherapy, 2015 Journal Article, 2015

O'Toole RF, Johari BM, Mac Aogáin M, Rogers TR, Bower JE, Basu I, Freeman JT., Short communication, Genome Announcements, 2 , (3), 2014, pe00319-14 Journal Article, 2014 URL DOI

Roycroft E, Mac Aogáin M, O'Toole RF, Fitzgibbon M, Rogers TR, Draft Genome Sequence of the First Isolate of Extensively Drug-Resistant Mycobacterium tuberculosis in Ireland., Genome announcements, 2, (5), 2014 Journal Article, 2014 TARA - Full Text DOI

Roycroft E, Mac Aogáin M, O'Toole RF, Fitzgibbon M, Rogers TR., Draft Genome Sequence of the First Isolate of Extensively Drug-Resistant Mycobacterium tuberculosis in Ireland., Genome announcements, 2014, ppii: e01002-14 Journal Article, 2014

Mac Aogáin M, Johari BM, Bower JE, O'Toole RF, Draft Genome Sequence of a Multidrug-Resistant New Zealand Isolate of Mycobacterium tuberculosis Lineage 3., Genome announcements, 2, (5), 2014 Journal Article, 2014 URL DOI TARA - Full Text

Mac Aogáin M, Bower JE, Basu I, Freeman JT, O'Toole RF, Draft Genome Sequence of a Drug-Susceptible New Zealand Isolate of Mycobacterium tuberculosis Lineage 3., Genome announcements, 3, (3), 2014 Journal Article, 2014 DOI TARA - Full Text

Fargier E, Mac Aogáin M, Mooij MJ, Woods DF, Morrissey JP, Dobson AD, Adams C, O'Gara F, MexT functions as a redox-responsive regulator modulating disulfide stress resistance in Pseudomonas aeruginosa., Journal of bacteriology, 194, (13), 2012, p3502-11 Journal Article, 2012

Mac Aogáin M, Mooij MJ, McCarthy RR, Plower E, Wang YP, Tian ZX, Dobson A, Morrissey J, Adams C, O'Gara F, The non-classical ArsR-family repressor PyeR (PA4354) modulates biofilm formation in Pseudomonas aeruginosa., Microbiology (Reading, England), 158, (Pt 10), 2012, p2598-609 Journal Article, 2012

Mac Aogáin M, Kulah C, Rijnsburger M, Celebi G, Savelkoul PH, O'Gara F, Mooij MJ, Characterization of imipenem resistance mechanisms in Pseudomonas aeruginosa isolates from Turkey., Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 18, (7), 2012, pE262-5 Journal Article, 2012

Mac Aogáin M, Mooij MJ, Adams C, Clair J, O'Gara F, Emergence of extended-spectrum beta-lactamase and fluoroquinolone resistance genes among Irish multidrug-resistant isolates., Diagnostic microbiology and infectious disease, 67, (1), 2010, p106-9 Journal Article, 2010

Tian ZX, Mac Aogáin M, O'Connor HF, Fargier E, Mooij MJ, Adams C, Wang YP, O'Gara F, MexT modulates virulence determinants in Pseudomonas aeruginosa independent of the MexEF-OprN efflux pump., Microbial pathogenesis, 47, (4), 2009, p237-41 Journal Article, 2009

Tian ZX, Fargier E, Mac Aogáin M, Adams C, Wang YP, O'Gara F, Transcriptome profiling defines a novel regulon modulated by the LysR-type transcriptional regulator MexT in Pseudomonas aeruginosa., Nucleic acids research, 37, (22), 2009, p7546-59 Journal Article, 2009

Non-Peer-Reviewed Publications

Mac Aogáin M, Rogers TR, Crowley B., Identification of emergent bla CMY-2 -carrying Proteus mirabilis lineages by whole-genome sequencing., New Microbes and New Infections, 27, (9), 2015, p58 - 62 Journal Article, 2015 URL

Mac Aogáin M, Roycroft E, Raftery P, Mok S, Fitzgibbon M, Rogers TR., Draft Genome Sequences of Three Mycobacterium chimaera Respiratory Isolates., Genome Announcements, 3, (6), 2015 Journal Article, 2015 URL

Research Expertise

Projects

  • Title
    • Evaluation of Next Generation Sequencing to Investigate the Epidemiology of Clostridium difficile Infection
  • Funding Agency
    • Health Reseach Board
  • Date From
    • 2014
  • Date To
    • 2017
  • Title
    • New insights into the transmission dynamics of healthcareassociated Clostridium difficile infection through whole-genome sequencing
  • Funding Agency
    • Astellas Pharma Ireland
  • Date From
    • 2013
  • Date To
    • 2014
  • Title
    • Molecular epidemiology and transcriptome sequencing of Irish Clostridium difficile isolates.
  • Funding Agency
    • Healthcare infection society
  • Date From
    • 2013
  • Date To
    • 2015