Professor Iracema Leroi
Associate Professor/Consultant, Psychiatry
Publications and Further Research Outputs
Peer-Reviewed Publications
Virginie Naël et al. and the Sense‑Cog consortium, Vision loss and 12-year risk of dementia in older adults: the 3C cohort study, European Journal of Epidemiology, 2019
, Parkinson"s-adapted cognitive stimulation therapy: feasibility and acceptability in Lewy body spectrum disorders, Journal of Neurology, 2019
, Hearing Impairment, Loneliness, Social Isolation, and Cognitive Function: Longitudinal Analysis Using English Longitudinal Study on Ageing, American Journal of Geriatric Psychiatry, 2019
Forsyth, K. and Henderson, C. and Davis, L. and Singh Roy, A. and Dunk, B. and Curnow, E. and Gathercole, R. and Lam, N. and Harper, E. and Leroi, I. and Woolham, J. and Fox, C. and O'Brien, J. and Bateman, A. and Poland, F. and Bentham, P. and Burns, A. and Davies, A. and Gray, R. and Bradley, R. and Knapp, M. and Newman, S. and McShane, R. and Ritchie, C. and Talbot, E. and Hooper, E. and Winson, R. and Scutt, B. and Ordonez, V. and Nunn, S. and Lavelle, G. and Howard, R., Assessment of need and practice for assistive technology and telecare for people with dementia"The ATTILA (Assistive Technology and Telecare to maintain Independent Living At home for people with dementia) trial, Alzheimer's and Dementia: Translational Research and Clinical Interventions, 2019
Leroi, I. and Himmelsbach, I. and Wolski, L. and Littlejohn, J. and Jury, F. and Parker, A. and Charalambous, A.P. and Dawes, P. and Constantinidou, F. and Thodi, C., Assessing and managing concurrent hearing, vision and cognitive impairments in older people: An international perspective from healthcare professionals, Age and Ageing, 2019
, Feasibility and Acceptability of Computerised Cognitive Training of Everyday Cognition in Parkinson's Disease, Parkinson's Disease, 2019
Linda Clare, Aleksandra Kudlicka, Jan R. Oyebode, Roy W. Jones, Antony Bayer, Iracema Leroi, et al, Individual goal"oriented cognitive rehabilitation to improve everyday functioning for people with early"stage dementia: A multicentre randomised controlled trial (the GREAT trial), International Journal of Geriatric Psychiatry, 2019
, Patient and public involvement in dementia research in the European Union: A scoping review, BMC Geriatrics, 2019
, Goal-oriented cognitive rehabilitation for early-stage alzheimer"s and related dementias: The GREAT RCT, Health Technology Assessment, 2019
, Protocol for the development of versions of the Montreal Cognitive Assessment (MoCA) for people with hearing or vision impairment, BMJ Open, 2019
, Deep and Frequent Phenotyping study protocol: An observational study in prodromal Alzheimer's disease, BMJ Open, 2019
, What is important to people living with dementia?: The 'long-list' of outcome items in the development of a core outcome set for use in the evaluation of non-pharmacological community-based health and social care interventions, BMC Geriatrics, 2019
Vatter, S.,Stanmore, E., Clare, L., McDonald, K.R.,McCormick, S.A. and Leroi, I., Care Burden and Mental Ill Health in Spouses of People With Parkinson Disease Dementia and Lewy Body Dementia, Journal of Geriatric Psychiatry and Neurology, 2019
, Feasibility of an Intervention to Support Hearing and Vision in Dementia: The SENSE-Cog Field Trial, Journal of the American Geriatrics Society, 2019
Wilcockson, T.D.W. and Mardanbegi, D. and Xia, B. and Taylor, S. and Sawyer, P. and Gellersen, H.W. and Leroi, I. and Killick, R. and Crawford, T.J., Abnormalities of saccadic eye movements in dementia due to Alzheimer's disease and mild cognitive impairment, Aging, 2019
, Individualised sensory intervention to improve quality of life in people with dementia and their companions (SENSE-Cog trial): Study protocol for a randomised controlled trial, Trials, 2019
Piers Dawes, Lucas Wolski, Ines Himmelsbach, Jemma Regan, Iracema Leroi, Interventions for hearing and vision impairment to improve outcomes for people with dementia: a scoping review, International Psychogeriatrics, 31, (2), 2019, p203--221
, Parkinson"s-adapted cognitive stimulation therapy: a pilot randomized controlled clinical trial, Therapeutic Advances in Neurological Disorders, 2019
, Which computer-use behaviours are most indicative of cognitive decline? Insights from an expert reference group, Health informatics journal, 2019
, Can you detect early dementia from an email? A proof of principle study of daily computer use to detect cognitive and functional decline, International Journal of Geriatric Psychiatry, 2018
, A protocol to evaluate the impact of involvement of older people with dementia and age-related hearing and/or vision impairment in a multi-site european research study, Research Involvement and Engagement, 2018
, Known and unknown requirements in healthcare, Requirements Engineering, 2018
, Developing a core outcome set for people living with dementia at home in their neighbourhoods and communities: Study protocol for use in the evaluation of non-pharmacological community-based health and social care interventions, Trials, 2018
, Bidirectional associations of vision and hearing loss with anxiety: Prospective findings from the Three-City Study, Age and Ageing, 2018
, Correction to: The Edinburgh Consensus: Preparing for the advent of disease-modifying therapies for Alzheimer's disease (Alzheimer's Research and Therapy (2017) 9 (85) DOI: 10.1186/s13195-017-0312-4), Alzheimer's Research and Therapy, 2018
, A qualitative study of female caregiving spouses' experiences of intimate relationships as cognition declines in Parkinson's disease, Age and Ageing, 2018
, Feasibility of a staff training and support programme to improve pain assessment and management in people with dementia living in care homes, International Journal of Geriatric Psychiatry, 2018
Fan Yang, Piers Dawes, Iracema Leroi, Brenda Gannon, Measurement tools of resource use and quality of life in clinical trials for dementia or cognitive impairment interventions: A systematically conducted narrative review, International Journal of Geriatric Psychiatry, 2018
, Longitudinal Relationship Between Hearing Aid Use and Cognitive Function in Older Americans, Journal of the American Geriatrics Society, 2018
, Multidimensional Care Burden in Parkinson-Related Dementia, Journal of Geriatric Psychiatry and Neurology, 2018
, Dementia in 'super-aged' Japan: challenges and solutions, Neurodegenerative disease management, 2018
Iracema Leroi, Kentaro Watanabe, Nick Hird, Taro Sugihara, "Psychogeritechnology" in Japan: Exemplars from a super-aged society, International Journal of Geriatric Psychiatry, 2018
, Research protocol for a complex intervention to support hearing and vision function to improve the lives of people with dementia, Pilot and Feasibility Studies, 2017
, The Edinburgh Consensus: Preparing for the advent of disease-modifying therapies for Alzheimer's disease, Alzheimer's Research and Therapy, 2017
, Pharmacological therapy and anxiolytics in patients with respiratory diseases, Depression and Anxiety in Patients with Chronic Respiratory Diseases, 2017
Iracema Leroi, Disrupted identities: movement, mind, and memory in Parkinson's disease, International Psychogeriatrics, 29, (06), 2017, p879--881
, Improving hearing and vision in dementia: Protocol for a field trial of a new intervention, BMJ Open, 2017
Annie Pye, Anna Pavlina Charalambous, Iracema Leroi, Chrysoulla Thodi, Piers Dawes, Screening tools for the identification of dementia for adults with age-related acquired hearing or vision impairment: a scoping review, International Psychogeriatrics, 29, (11), 2017, p1771--1784
, Psychosocial therapy for Parkinson"s-related dementia: Intervention development, Clinical Interventions in Aging, 2017
, The impact of individual Cognitive Stimulation Therapy (iCST) on cognition, quality of life, caregiver health, and family relationships in dementia: A randomised controlled trial, PLoS Medicine, 2017
, Cognitive Impairment in Chronic Obstructive Pulmonary Disease and Chronic Heart Failure: A Systematic Review and Meta-analysis of Observational Studies, Journal of the American Medical Directors Association, 2017
, Measurement tools of resource use and quality of life in clinical trials for dementia or cognitive impairment interventions: Protocol for a scoping review, Systematic Reviews, 2017
, Psychosocial therapy for Parkinson's-related dementia: Study protocol for the INVEST randomised controlled trial, BMJ Open, 2017
, Neuropsychiatric aspects of dementia, Dementia, Fifth Edition, 2017
, Editorial: ICT for assessment and rehabilitation in alzheimer's disease and related disorders, Frontiers in Aging Neuroscience, 2016
, Treat the brain to improve the lungs?: Mental illness as a risk factor for readmission in COPD, Chest, 2016
, Combining Mouse and Keyboard Events with Higher Level Desktop Actions to Detect Mild Cognitive Impairment, Proceedings - 2016 IEEE International Conference on Healthcare Informatics, ICHI 2016, 2016
, Cognitive training interventions for dementia and mild cognitive impairment in Parkinson's Disease, Cochrane Database of Systematic Reviews, 2015
, Individual cognitive stimulation therapy for dementia: A clinical effectiveness and cost-effectiveness pragmatic, multicentre, randomised controlled trial, Health Technology Assessment, 2015
, Experiences of apathy in people with Parkinson's disease: A qualitative exploration, Disability and Rehabilitation, 2015
, From click to cognition: Detecting cognitive decline through daily computer use, The Preservation of Memory, 2015
, Memantine improves goal attainment and reduces caregiver burden in Parkinson's disease with dementia, International Journal of Geriatric Psychiatry, 2014
, Arterial spin labelling reveals prolonged arterial arrival time in idiopathic Parkinson's disease, NeuroImage: Clinical, 2014
, Perceptions of cause and control in people with alzheimer's disease, Gerontologist, 2014
, Clinical profile of compulsive sexual behaviour and paraphilia in Parkinson's disease, Journal of Parkinson's Disease, 2014
, Lithium in patients with amyotrophic lateral sclerosis (LiCALS): A phase 3 multicentre, randomised, double-blind, placebo-controlled trial, The Lancet Neurology, 2013
, Does telecare prolong community living in dementia? A study protocol for a pragmatic, randomised controlled trial, Trials, 2013
, Dopaminergic influences on executive function and impulsive behaviour in impulse control disorders in Parkinson's disease, Journal of Neuropsychology, 2013
, Goal-oriented cognitive rehabilitation in early-stage dementia: Study protocol for a multi-centre single-blind randomised controlled trial (GREAT), Trials, 2013
, Perceptions of cause and control of impulse control behaviours in people with Parkinson's disease, British Journal of Health Psychology, 2012
, Functional dementia assessment using a video monitoring system: Proof of concept, Gerontechnology, 2012
, Neuropsychiatric symptoms in parkinsons disease with mild cognitive impairment and dementia, Parkinson's Disease, 2012
, Apathy and impulse control disorders in Parkinson's disease: A direct comparison, Parkinsonism and Related Disorders, 2012
, Impulse control disorders in parkinson's disease: A psychosocial perspective, Journal of Clinical Psychology in Medical Settings, 2012
, Apathy in Parkinson's disease, Advances in Biological Psychiatry, 2012
, An exploration of apathy and impulsivity in Parkinson disease, Current Gerontology and Geriatrics Research, 2012
, Cognitive impairment in parkinson disease: Impact on quality of life, disability, and caregiver burden, Journal of Geriatric Psychiatry and Neurology, 2012
, Carer burden in apathy and impulse control disorders in Parkinson's disease, International Journal of Geriatric Psychiatry, 2012
, Automatic video monitoring system for assessment of alzheimer's disease symptoms, Journal of Nutrition, Health and Aging, 2012
, Apathy in the elderly: From assessment to treatment, Current Gerontology and Geriatrics Research, 2012
, Behavioural disorders, disability and quality of life in Parkinson's disease, Age and Ageing, 2011
, A pilot randomized controlled trial of sleep therapy in Parkinson's disease: Effect on patients and caregivers, International Journal of Geriatric Psychiatry, 2010
, Randomized controlled trial of memantine in Dementia associated with Parkinson's disease, Movement Disorders, 2009
, Memantine in patients with Parkinson's disease dementia or dementia with Lewy bodies: a double-blind, placebo-controlled, multicentre trial, The Lancet Neurology, 2009
, Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): Scale presentation and clinimetric testing results, Movement Disorders, 2008
, A comparison of small and large assisted living facilities for the diagnosis and care of dementia: The Maryland assisted living study, International Journal of Geriatric Psychiatry, 2007
, Behavioural and psychological symptoms of dementia associated with Parkinson's disease, Journal of Neurology, Neurosurgery and Psychiatry, 2007
, Non-dopaminergic treatment of cognitive impairment and dementia in Parkinson's disease: A review, Journal of the Neurological Sciences, 2006
, Cognitive Impairments in Cerebellar Degeneration: A Comparison with Huntington's Disease, Journal of Neuropsychiatry and Clinical Neurosciences, 2004
, Randomized placebo-controlled trial of donepezil in cognitive impairment in Parkinson's disease, International Journal of Geriatric Psychiatry, 2004
, Amantadine for Executive Dysfunction Syndrome in Patients with Dementia, Psychosomatics, 2004
, Cognitive Impairment and Psychiatric Symptoms in 133 Patients with Diseases Associated with Cerebellar Degeneration, Journal of Neuropsychiatry and Clinical Neurosciences, 2004
, Re: "cognitive function after 11.5 years of alcohol use: Relation to alcohol use" [3] (multiple letters), American Journal of Epidemiology, 2003
, The epidemiology of psychosis in dementia, American Journal of Geriatric Psychiatry, 2003
, Cognitive function after 11.5 years of alcohol use: Relation to alcohol use, American Journal of Epidemiology, 2002
, Psychopathology in patients with degenerative cerebellar diseases: A comparison to Huntington's disease, American Journal of Psychiatry, 2002
, Successful multimodality treatment of severe behavioral disturbance in a patient with advanced Huntington's disease, American Journal of Psychiatry, 2001
, Psychiatric syndromes in cerebellar degeneration, International Review of Psychiatry, 2001
, Neuropsychiatry of Huntington's disease and other basal ganglia disorders, Psychosomatics, 2000
, The care of patients with dementia, Reviews in Clinical Gerontology, 1999
, Treatment of the psychiatric manifestations of Huntington's disease: A review of the literature, Canadian Journal of Psychiatry, 1998
, Psychotic depression: An atypical initial presentation of multiple sclerosis, Psychosomatics, 1998
, Fluoxetine-imipramine interaction [4], Canadian Journal of Psychiatry, 1996
Recognition
Awards and Honours
Grant: Lead applicant: HRB CRN Scheme. 1million euro. 'Dementia Trials Ireland'
Grant: Lead applicant: HRB DIFA Scheme. 431,000 euro. 'SENSE-Cog Care: Hearing and Vision in Care Homes in Ireland'
Grant: Lead applicant: EU Horizon2020: 6.7 million euro. 'SENSE-Cog: Hearing and vision in dementia'
Grant: Lead applicant: Irish Research Board: 12,000 euro. 'COVID-related loneliness and social isolation in carers of people with brain health challenges'
Grant: Lead applicant: GBHI Funding. $125,000: 'Developing a PPI Program for GBHI'
Grant: Lead applicant: ESTHER Ireland. 8000 euro. 'Bengali-Irish Partnership for Brain Health'
Grant: Lead applicant: Trinity Covid Response Fund: 6400 euro. 'Exploring Coping in Care Partners during COVID-19'
Grant: Lead applicant: MRC Global Clinical Research Fund (GCRF)GCRF (UK). £20,000. 'PakAGE: Developing the infrastructure for a longitudinal study of aging in Pakistan'
Travel Grant: UK-Pakistan Global Development Workshop for Affordable Healthcare (UPSIGN-COMSATS), Islamabad
Grant: Lead applicant: MRC Global Clinical Research Fund (GCRF)GCRF (UK). £38,000. 'SENSE-Cog Asia: Feasibility study of hearing augmentation in dementia in South Asia''
Grant: Lead applicant: NIHR RfPB scheme. £342,000; 'INVEST: Cognitive Stimulation for Dementia in Parkinson's Disease'
Grant: Lead applicant: Data Science Institute Pump Prime. £10,000. Novel methods for analysing gait patterns in cognitive impairment.
Grant: Lead applicant: INNOVATE UK. £150,000. CYGNUS: Digital Platform for Memory Clinic Data Collection
Grant: Lead applicant: MICRA (U Manch). £6000. 'Lost Memory Lost Way: Technology to address wandering in dementia'
Grant: Lead applicant: MICRA SeedCorn funds. £6,000. 'Is the retina truly a window to the brain?'
Grant: Lead applicant: ISSF-Wellcome Trust. £26,000. Manchester High Schools' Dementia Ambassadors' Program
Grant: Lead applicant: Parkinson's UK Senior Fellowship: £239,000. Clinical and neural correlates of ICD in Parkinson's Disease.
Grant: Lead applicant: Lundbeck Unrestricted. £48,000: 'RCT of Memantine in Parkinson's Dementia'
Grant: Lead applicant: Pfizer Unrestricted. $121,000. RCT of donepezil in Parkinson's Dementia
Grant: Lead applicant: Johns Hopkins NBRU. $35,000. Donepezil in PDD
Grant: Co-applicant (PPI Lead): UK NIHR (HTA): COBALT - RCT of memantine in PDD/DLB
Grant: Co-applicant: ERASMUS Plus: 437,000 euro: oMERO: Developing a Professional Profile for a Visual Disabilities Rehabilitator
Grant: Co-applicant : MRC RCUK: £1.6 million; SASHI/SAHAR - Self Harm in South Asia
Grant: Co-applicant (Site PI): UK NIHR (HTA): £1.8 million; SYMBAD - RCT of mirtazepine/CBZ in Alzheimer
Grant: Co-applicant (Clinical Lead): EPSRC: £1 million 'MODEM: Sensing in dementia'
Grant: Co-applicant (Clinical Lead): EPSRC: £610,000: 'SAM: Self-management of mental health and dementia'
Grant: Co-applicant (Site PI): NIHR (HTA): £1 million; 'MADE: Minocycline in Dementia'
Grant: Co-applicant (Clinical Lead): ESRC (UK); £5million. 'Neighbourhoods and Dementia'
Grant: Co-applicant (Site PI): NIHR (HTA):£180,000: 'ATILLA: RCT of Assisted Technology in Dementia'
Grant: Co-applicant (Site PI): NIHR (HTA): £2.4 million. 'GREAT: RCT of Cognitive Rehabilitation in Dementia'
Grant: Co-applicant (PPI Lead): UK NIHR (HTA): £1.1 million; 'iCST: individualised CST in dementia'
Grant: Co-applicant: NARSAD (USA): $50,000. Neuropsychiatric Aspects of Spinocerebellar Ataxia
Memberships
ISTAART, Alzheimer Association (USA)
European Dementia with Lewy Body (E-DLB) consortium
International Society for Fronto Temporal Dementia (ISFTD)
British Medical Association (BMA)
Royal College of Physicians of Edinburgh
American Congress of Rehabilitation Medicine (ACRM)
Royal College of Psychiatrists, UK
American Neuropsychiatric Association (ANPA)
American Psychiatric Association