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Professor Iracema Leroi
Associate Professor/Consultant, Psychiatry

Publications and Further Research Outputs

Peer-Reviewed Publications

Virginie Naël et al. and the Sense‑Cog consortium, Vision loss and 12-year risk of dementia in older adults: the 3C cohort study, European Journal of Epidemiology, 2019 Journal Article, 2019

, Parkinson"s-adapted cognitive stimulation therapy: feasibility and acceptability in Lewy body spectrum disorders, Journal of Neurology, 2019 Journal Article, 2019

, Hearing Impairment, Loneliness, Social Isolation, and Cognitive Function: Longitudinal Analysis Using English Longitudinal Study on Ageing, American Journal of Geriatric Psychiatry, 2019 Journal Article, 2019

Forsyth, K. and Henderson, C. and Davis, L. and Singh Roy, A. and Dunk, B. and Curnow, E. and Gathercole, R. and Lam, N. and Harper, E. and Leroi, I. and Woolham, J. and Fox, C. and O'Brien, J. and Bateman, A. and Poland, F. and Bentham, P. and Burns, A. and Davies, A. and Gray, R. and Bradley, R. and Knapp, M. and Newman, S. and McShane, R. and Ritchie, C. and Talbot, E. and Hooper, E. and Winson, R. and Scutt, B. and Ordonez, V. and Nunn, S. and Lavelle, G. and Howard, R., Assessment of need and practice for assistive technology and telecare for people with dementia"The ATTILA (Assistive Technology and Telecare to maintain Independent Living At home for people with dementia) trial, Alzheimer's and Dementia: Translational Research and Clinical Interventions, 2019 Journal Article, 2019

Leroi, I. and Himmelsbach, I. and Wolski, L. and Littlejohn, J. and Jury, F. and Parker, A. and Charalambous, A.P. and Dawes, P. and Constantinidou, F. and Thodi, C., Assessing and managing concurrent hearing, vision and cognitive impairments in older people: An international perspective from healthcare professionals, Age and Ageing, 2019 Journal Article, 2019

, Feasibility and Acceptability of Computerised Cognitive Training of Everyday Cognition in Parkinson's Disease, Parkinson's Disease, 2019 Journal Article, 2019

Linda Clare, Aleksandra Kudlicka, Jan R. Oyebode, Roy W. Jones, Antony Bayer, Iracema Leroi, et al, Individual goal"oriented cognitive rehabilitation to improve everyday functioning for people with early"stage dementia: A multicentre randomised controlled trial (the GREAT trial), International Journal of Geriatric Psychiatry, 2019 Journal Article, 2019

, Patient and public involvement in dementia research in the European Union: A scoping review, BMC Geriatrics, 2019 Journal Article, 2019

, Goal-oriented cognitive rehabilitation for early-stage alzheimer"s and related dementias: The GREAT RCT, Health Technology Assessment, 2019 Journal Article, 2019

, Protocol for the development of versions of the Montreal Cognitive Assessment (MoCA) for people with hearing or vision impairment, BMJ Open, 2019 Journal Article, 2019

, Deep and Frequent Phenotyping study protocol: An observational study in prodromal Alzheimer's disease, BMJ Open, 2019 Journal Article, 2019

, What is important to people living with dementia?: The 'long-list' of outcome items in the development of a core outcome set for use in the evaluation of non-pharmacological community-based health and social care interventions, BMC Geriatrics, 2019 Journal Article, 2019

Vatter, S.,Stanmore, E., Clare, L., McDonald, K.R.,McCormick, S.A. and Leroi, I., Care Burden and Mental Ill Health in Spouses of People With Parkinson Disease Dementia and Lewy Body Dementia, Journal of Geriatric Psychiatry and Neurology, 2019 Journal Article, 2019

, Feasibility of an Intervention to Support Hearing and Vision in Dementia: The SENSE-Cog Field Trial, Journal of the American Geriatrics Society, 2019 Journal Article, 2019

Wilcockson, T.D.W. and Mardanbegi, D. and Xia, B. and Taylor, S. and Sawyer, P. and Gellersen, H.W. and Leroi, I. and Killick, R. and Crawford, T.J., Abnormalities of saccadic eye movements in dementia due to Alzheimer's disease and mild cognitive impairment, Aging, 2019 Journal Article, 2019

, Individualised sensory intervention to improve quality of life in people with dementia and their companions (SENSE-Cog trial): Study protocol for a randomised controlled trial, Trials, 2019 Journal Article, 2019

Piers Dawes, Lucas Wolski, Ines Himmelsbach, Jemma Regan, Iracema Leroi, Interventions for hearing and vision impairment to improve outcomes for people with dementia: a scoping review, International Psychogeriatrics, 31, (2), 2019, p203--221 Journal Article, 2019

, Parkinson"s-adapted cognitive stimulation therapy: a pilot randomized controlled clinical trial, Therapeutic Advances in Neurological Disorders, 2019 Journal Article, 2019

, Which computer-use behaviours are most indicative of cognitive decline? Insights from an expert reference group, Health informatics journal, 2019 Journal Article, 2019

, Can you detect early dementia from an email? A proof of principle study of daily computer use to detect cognitive and functional decline, International Journal of Geriatric Psychiatry, 2018 Journal Article, 2018

, A protocol to evaluate the impact of involvement of older people with dementia and age-related hearing and/or vision impairment in a multi-site european research study, Research Involvement and Engagement, 2018 Journal Article, 2018

, Known and unknown requirements in healthcare, Requirements Engineering, 2018 Journal Article, 2018

, Developing a core outcome set for people living with dementia at home in their neighbourhoods and communities: Study protocol for use in the evaluation of non-pharmacological community-based health and social care interventions, Trials, 2018 Journal Article, 2018

, Bidirectional associations of vision and hearing loss with anxiety: Prospective findings from the Three-City Study, Age and Ageing, 2018 Journal Article, 2018

, Correction to: The Edinburgh Consensus: Preparing for the advent of disease-modifying therapies for Alzheimer's disease (Alzheimer's Research and Therapy (2017) 9 (85) DOI: 10.1186/s13195-017-0312-4), Alzheimer's Research and Therapy, 2018 Journal Article, 2018

, A qualitative study of female caregiving spouses' experiences of intimate relationships as cognition declines in Parkinson's disease, Age and Ageing, 2018 Journal Article, 2018

, Feasibility of a staff training and support programme to improve pain assessment and management in people with dementia living in care homes, International Journal of Geriatric Psychiatry, 2018 Journal Article, 2018

Fan Yang, Piers Dawes, Iracema Leroi, Brenda Gannon, Measurement tools of resource use and quality of life in clinical trials for dementia or cognitive impairment interventions: A systematically conducted narrative review, International Journal of Geriatric Psychiatry, 2018 Journal Article, 2018

, Longitudinal Relationship Between Hearing Aid Use and Cognitive Function in Older Americans, Journal of the American Geriatrics Society, 2018 Journal Article, 2018

, Multidimensional Care Burden in Parkinson-Related Dementia, Journal of Geriatric Psychiatry and Neurology, 2018 Journal Article, 2018

, Dementia in 'super-aged' Japan: challenges and solutions, Neurodegenerative disease management, 2018 Journal Article, 2018

Iracema Leroi, Kentaro Watanabe, Nick Hird, Taro Sugihara, "Psychogeritechnology" in Japan: Exemplars from a super-aged society, International Journal of Geriatric Psychiatry, 2018 Journal Article, 2018

, Research protocol for a complex intervention to support hearing and vision function to improve the lives of people with dementia, Pilot and Feasibility Studies, 2017 Journal Article, 2017

, The Edinburgh Consensus: Preparing for the advent of disease-modifying therapies for Alzheimer's disease, Alzheimer's Research and Therapy, 2017 Journal Article, 2017

, Pharmacological therapy and anxiolytics in patients with respiratory diseases, Depression and Anxiety in Patients with Chronic Respiratory Diseases, 2017 Journal Article, 2017

Iracema Leroi, Disrupted identities: movement, mind, and memory in Parkinson's disease, International Psychogeriatrics, 29, (06), 2017, p879--881 Journal Article, 2017

, Improving hearing and vision in dementia: Protocol for a field trial of a new intervention, BMJ Open, 2017 Journal Article, 2017

Annie Pye, Anna Pavlina Charalambous, Iracema Leroi, Chrysoulla Thodi, Piers Dawes, Screening tools for the identification of dementia for adults with age-related acquired hearing or vision impairment: a scoping review, International Psychogeriatrics, 29, (11), 2017, p1771--1784 Journal Article, 2017

, Psychosocial therapy for Parkinson"s-related dementia: Intervention development, Clinical Interventions in Aging, 2017 Journal Article, 2017

, The impact of individual Cognitive Stimulation Therapy (iCST) on cognition, quality of life, caregiver health, and family relationships in dementia: A randomised controlled trial, PLoS Medicine, 2017 Journal Article, 2017

, Cognitive Impairment in Chronic Obstructive Pulmonary Disease and Chronic Heart Failure: A Systematic Review and Meta-analysis of Observational Studies, Journal of the American Medical Directors Association, 2017 Journal Article, 2017

, Measurement tools of resource use and quality of life in clinical trials for dementia or cognitive impairment interventions: Protocol for a scoping review, Systematic Reviews, 2017 Journal Article, 2017

, Psychosocial therapy for Parkinson's-related dementia: Study protocol for the INVEST randomised controlled trial, BMJ Open, 2017 Journal Article, 2017

, Neuropsychiatric aspects of dementia, Dementia, Fifth Edition, 2017 Journal Article, 2017

, Editorial: ICT for assessment and rehabilitation in alzheimer's disease and related disorders, Frontiers in Aging Neuroscience, 2016 Journal Article, 2016

, Treat the brain to improve the lungs?: Mental illness as a risk factor for readmission in COPD, Chest, 2016 Journal Article, 2016

, Combining Mouse and Keyboard Events with Higher Level Desktop Actions to Detect Mild Cognitive Impairment, Proceedings - 2016 IEEE International Conference on Healthcare Informatics, ICHI 2016, 2016 Journal Article, 2016

, Cognitive training interventions for dementia and mild cognitive impairment in Parkinson's Disease, Cochrane Database of Systematic Reviews, 2015 Journal Article, 2015

, Individual cognitive stimulation therapy for dementia: A clinical effectiveness and cost-effectiveness pragmatic, multicentre, randomised controlled trial, Health Technology Assessment, 2015 Journal Article, 2015

, Experiences of apathy in people with Parkinson's disease: A qualitative exploration, Disability and Rehabilitation, 2015 Journal Article, 2015

, From click to cognition: Detecting cognitive decline through daily computer use, The Preservation of Memory, 2015 Journal Article, 2015

, Memantine improves goal attainment and reduces caregiver burden in Parkinson's disease with dementia, International Journal of Geriatric Psychiatry, 2014 Journal Article, 2014

, Arterial spin labelling reveals prolonged arterial arrival time in idiopathic Parkinson's disease, NeuroImage: Clinical, 2014 Journal Article, 2014

, Perceptions of cause and control in people with alzheimer's disease, Gerontologist, 2014 Journal Article, 2014

, Clinical profile of compulsive sexual behaviour and paraphilia in Parkinson's disease, Journal of Parkinson's Disease, 2014 Journal Article, 2014

, Lithium in patients with amyotrophic lateral sclerosis (LiCALS): A phase 3 multicentre, randomised, double-blind, placebo-controlled trial, The Lancet Neurology, 2013 Journal Article, 2013

, Does telecare prolong community living in dementia? A study protocol for a pragmatic, randomised controlled trial, Trials, 2013 Journal Article, 2013

, Dopaminergic influences on executive function and impulsive behaviour in impulse control disorders in Parkinson's disease, Journal of Neuropsychology, 2013 Journal Article, 2013

, Goal-oriented cognitive rehabilitation in early-stage dementia: Study protocol for a multi-centre single-blind randomised controlled trial (GREAT), Trials, 2013 Journal Article, 2013

, Perceptions of cause and control of impulse control behaviours in people with Parkinson's disease, British Journal of Health Psychology, 2012 Journal Article, 2012

, Functional dementia assessment using a video monitoring system: Proof of concept, Gerontechnology, 2012 Journal Article, 2012

, Neuropsychiatric symptoms in parkinsons disease with mild cognitive impairment and dementia, Parkinson's Disease, 2012 Journal Article, 2012

, Apathy and impulse control disorders in Parkinson's disease: A direct comparison, Parkinsonism and Related Disorders, 2012 Journal Article, 2012

, Impulse control disorders in parkinson's disease: A psychosocial perspective, Journal of Clinical Psychology in Medical Settings, 2012 Journal Article, 2012

, Apathy in Parkinson's disease, Advances in Biological Psychiatry, 2012 Journal Article, 2012

, An exploration of apathy and impulsivity in Parkinson disease, Current Gerontology and Geriatrics Research, 2012 Journal Article, 2012

, Cognitive impairment in parkinson disease: Impact on quality of life, disability, and caregiver burden, Journal of Geriatric Psychiatry and Neurology, 2012 Journal Article, 2012

, Carer burden in apathy and impulse control disorders in Parkinson's disease, International Journal of Geriatric Psychiatry, 2012 Journal Article, 2012

, Automatic video monitoring system for assessment of alzheimer's disease symptoms, Journal of Nutrition, Health and Aging, 2012 Journal Article, 2012

, Apathy in the elderly: From assessment to treatment, Current Gerontology and Geriatrics Research, 2012 Journal Article, 2012

, Behavioural disorders, disability and quality of life in Parkinson's disease, Age and Ageing, 2011 Journal Article, 2011

, A pilot randomized controlled trial of sleep therapy in Parkinson's disease: Effect on patients and caregivers, International Journal of Geriatric Psychiatry, 2010 Journal Article, 2010

, Randomized controlled trial of memantine in Dementia associated with Parkinson's disease, Movement Disorders, 2009 Journal Article, 2009

, Memantine in patients with Parkinson's disease dementia or dementia with Lewy bodies: a double-blind, placebo-controlled, multicentre trial, The Lancet Neurology, 2009 Journal Article, 2009

, Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): Scale presentation and clinimetric testing results, Movement Disorders, 2008 Journal Article, 2008

, A comparison of small and large assisted living facilities for the diagnosis and care of dementia: The Maryland assisted living study, International Journal of Geriatric Psychiatry, 2007 Journal Article, 2007

, Behavioural and psychological symptoms of dementia associated with Parkinson's disease, Journal of Neurology, Neurosurgery and Psychiatry, 2007 Journal Article, 2007

, Non-dopaminergic treatment of cognitive impairment and dementia in Parkinson's disease: A review, Journal of the Neurological Sciences, 2006 Journal Article, 2006

, Cognitive Impairments in Cerebellar Degeneration: A Comparison with Huntington's Disease, Journal of Neuropsychiatry and Clinical Neurosciences, 2004 Journal Article, 2004

, Randomized placebo-controlled trial of donepezil in cognitive impairment in Parkinson's disease, International Journal of Geriatric Psychiatry, 2004 Journal Article, 2004

, Amantadine for Executive Dysfunction Syndrome in Patients with Dementia, Psychosomatics, 2004 Journal Article, 2004

, Cognitive Impairment and Psychiatric Symptoms in 133 Patients with Diseases Associated with Cerebellar Degeneration, Journal of Neuropsychiatry and Clinical Neurosciences, 2004 Journal Article, 2004

, Re: "cognitive function after 11.5 years of alcohol use: Relation to alcohol use" [3] (multiple letters), American Journal of Epidemiology, 2003 Journal Article, 2003

, The epidemiology of psychosis in dementia, American Journal of Geriatric Psychiatry, 2003 Journal Article, 2003

, Cognitive function after 11.5 years of alcohol use: Relation to alcohol use, American Journal of Epidemiology, 2002 Journal Article, 2002

, Psychopathology in patients with degenerative cerebellar diseases: A comparison to Huntington's disease, American Journal of Psychiatry, 2002 Journal Article, 2002

, Successful multimodality treatment of severe behavioral disturbance in a patient with advanced Huntington's disease, American Journal of Psychiatry, 2001 Journal Article, 2001

, Psychiatric syndromes in cerebellar degeneration, International Review of Psychiatry, 2001 Journal Article, 2001

, Neuropsychiatry of Huntington's disease and other basal ganglia disorders, Psychosomatics, 2000 Journal Article, 2000

, The care of patients with dementia, Reviews in Clinical Gerontology, 1999 Journal Article, 1999

, Treatment of the psychiatric manifestations of Huntington's disease: A review of the literature, Canadian Journal of Psychiatry, 1998 Journal Article, 1998

, Psychotic depression: An atypical initial presentation of multiple sclerosis, Psychosomatics, 1998 Journal Article, 1998

, Fluoxetine-imipramine interaction [4], Canadian Journal of Psychiatry, 1996 Journal Article, 1996

Recognition

Awards and Honours

Grant: Lead applicant: HRB CRN Scheme. 1million euro. 'Dementia Trials Ireland' 2021-2025

Grant: Lead applicant: HRB DIFA Scheme. 431,000 euro. 'SENSE-Cog Care: Hearing and Vision in Care Homes in Ireland' 2021-2023

Grant: Lead applicant: EU Horizon2020: 6.7 million euro. 'SENSE-Cog: Hearing and vision in dementia' 2017-2022

Grant: Lead applicant: Irish Research Board: 12,000 euro. 'COVID-related loneliness and social isolation in carers of people with brain health challenges' 2021-2022

Grant: Lead applicant: GBHI Funding. $125,000: 'Developing a PPI Program for GBHI' 2020-2024

Grant: Lead applicant: ESTHER Ireland. 8000 euro. 'Bengali-Irish Partnership for Brain Health' 2020

Grant: Lead applicant: Trinity Covid Response Fund: 6400 euro. 'Exploring Coping in Care Partners during COVID-19' 2020-2021

Grant: Lead applicant: MRC Global Clinical Research Fund (GCRF)GCRF (UK). £20,000. 'PakAGE: Developing the infrastructure for a longitudinal study of aging in Pakistan' 2019-2020

Travel Grant: UK-Pakistan Global Development Workshop for Affordable Healthcare (UPSIGN-COMSATS), Islamabad 2020

Grant: Lead applicant: MRC Global Clinical Research Fund (GCRF)GCRF (UK). £38,000. 'SENSE-Cog Asia: Feasibility study of hearing augmentation in dementia in South Asia'' 2019-2021

Grant: Lead applicant: NIHR RfPB scheme. £342,000; 'INVEST: Cognitive Stimulation for Dementia in Parkinson's Disease' 2014-2018

Grant: Lead applicant: Data Science Institute Pump Prime. £10,000. Novel methods for analysing gait patterns in cognitive impairment. 2017

Grant: Lead applicant: INNOVATE UK. £150,000. CYGNUS: Digital Platform for Memory Clinic Data Collection 2015-2018

Grant: Lead applicant: MICRA (U Manch). £6000. 'Lost Memory Lost Way: Technology to address wandering in dementia' 2016

Grant: Lead applicant: MICRA SeedCorn funds. £6,000. 'Is the retina truly a window to the brain?' 2014

Grant: Lead applicant: ISSF-Wellcome Trust. £26,000. Manchester High Schools' Dementia Ambassadors' Program 2014-2015

Grant: Lead applicant: Parkinson's UK Senior Fellowship: £239,000. Clinical and neural correlates of ICD in Parkinson's Disease. 2007-2011

Grant: Lead applicant: Lundbeck Unrestricted. £48,000: 'RCT of Memantine in Parkinson's Dementia' 2003-2006

Grant: Lead applicant: Pfizer Unrestricted. $121,000. RCT of donepezil in Parkinson's Dementia 2000-2002

Grant: Lead applicant: Johns Hopkins NBRU. $35,000. Donepezil in PDD 2000

Grant: Co-applicant (PPI Lead): UK NIHR (HTA): COBALT - RCT of memantine in PDD/DLB 2020-2024

Grant: Co-applicant: ERASMUS Plus: 437,000 euro: oMERO: Developing a Professional Profile for a Visual Disabilities Rehabilitator 2020-2025

Grant: Co-applicant : MRC RCUK: £1.6 million; SASHI/SAHAR - Self Harm in South Asia 2017-2022

Grant: Co-applicant (Site PI): UK NIHR (HTA): £1.8 million; SYMBAD - RCT of mirtazepine/CBZ in Alzheimer 2015-2019

Grant: Co-applicant (Clinical Lead): EPSRC: £1 million 'MODEM: Sensing in dementia' 2015-2019

Grant: Co-applicant (Clinical Lead): EPSRC: £610,000: 'SAM: Self-management of mental health and dementia' 2014-2018

Grant: Co-applicant (Site PI): NIHR (HTA): £1 million; 'MADE: Minocycline in Dementia' 2014-2018

Grant: Co-applicant (Clinical Lead): ESRC (UK); £5million. 'Neighbourhoods and Dementia' 2014-2019

Grant: Co-applicant (Site PI): NIHR (HTA):£180,000: 'ATILLA: RCT of Assisted Technology in Dementia' 2012-2017

Grant: Co-applicant (Site PI): NIHR (HTA): £2.4 million. 'GREAT: RCT of Cognitive Rehabilitation in Dementia' 2012-2017

Grant: Co-applicant (PPI Lead): UK NIHR (HTA): £1.1 million; 'iCST: individualised CST in dementia' 2012-2017

Grant: Co-applicant: NARSAD (USA): $50,000. Neuropsychiatric Aspects of Spinocerebellar Ataxia 2001-2003

Memberships

ISTAART, Alzheimer Association (USA) 2021

European Dementia with Lewy Body (E-DLB) consortium 2021

International Society for Fronto Temporal Dementia (ISFTD) 2021

British Medical Association (BMA) 2002 – 2019

Royal College of Physicians of Edinburgh 2017

American Congress of Rehabilitation Medicine (ACRM) 2018

Royal College of Psychiatrists, UK 2002 – 2019

American Neuropsychiatric Association (ANPA) 2002 – 2015

American Psychiatric Association 1993 – 2010