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Dr. Brian Kent
Clinical Senior Lecturer, Clinical Medicine

Publications and Further Research Outputs

Peer-Reviewed Publications

Hearn AP, Kavanagh J, d'Ancona G, Roxas C, Green L, Thomson L, Fernandes M, Kent BD, Dhariwal J, Nanzer AM, Jackson DJ., The relationship between Feno and effectiveness of mepolizumab and benralizumab in severe eosinophilic asthma., The journal of allergy and clinical immunology. In practice, 9, (5), 2021, p2093-2096.e1 Journal Article, 2021 DOI

d'Ancona G, Kent BD., Practical Applications of FeNO Measurement and Inhaler Monitoring Technologies in the Management of Difficult Asthma., The journal of allergy and clinical immunology. In practice, 9, (4), 2021, p1539-1540 Journal Article, 2021 DOI

d'Ancona G, Kavanagh JE, Dhariwal J, Hearn AP, Roxas C, Fernandes M, Green L, Thomson L, Nanzer AM, Jackson DJ, Kent BD., Adherence to inhaled corticosteroids and clinical outcomes following a year of benralizumab therapy for severe eosinophilic asthma., Allergy, 2021 Journal Article, 2021 DOI

Dhariwal J, Hearn AP, Kavanagh JE, d'Ancona G, Green L, Fernandes M, Thomson L, Roxas C, Kent BD, Nanzer AM, Jackson DJ., Real-World Effectiveness of Anti-IL-5/5R Therapy in Severe Atopic Eosinophilic Asthma with Fungal Sensitization., The journal of allergy and clinical immunology. In practice, 2021 Journal Article, 2021 DOI

Hearn AP, Hug OD, Somani ZA, Kavanagh J, d'Ancona G, Roxas C, Green L, Thomson L, Fernandes M, Kent BD, Dhariwal J, Nanzer AM, Jackson DJ., Real world effectiveness of anti-IL-5/5R therapies is independent of co-eligibility for anti-IgE therapy., The European respiratory journal, 2021 Journal Article, 2021 DOI

Kavanagh JE, Hearn AP, Dhariwal J, d'Ancona G, Douiri A, Roxas C, Fernandes M, Green L, Thomson L, Nanzer AM, Kent BD, Jackson DJ., Real-World Effectiveness of Benralizumab in Severe Eosinophilic Asthma., Chest, 159, (2), 2021, p496-506 Journal Article, 2021 DOI

Grote L, McNicholas WT, Hedner J, ESADA collaborators., Sleep apnoea management in Europe during the COVID-19 pandemic: data from the European Sleep Apnoea Database (ESADA)., The European respiratory journal, 55, (6), 2020 Journal Article, 2020 DOI

Sleep Disorders. in, editor(s)Mayur Bodani, Rafey Faruqui, Nirul Agrawal , Oxford Textbook of Neuropsychiatry. , Oxford University Press. , 2020, [Leschziner GD, Kent BD] Book Chapter, 2020

Pérez-Carbonell L, Lyons E, Gnoni V, Higgins S, Otaiku AI, Leschziner GD, Drakatos P, d'Ancona G, Kent BD., Adherence to wakefulness promoting medication in patients with narcolepsy., Sleep medicine, 70, 2020, p50-54 Journal Article, 2020 DOI

Kavanagh JE, d'Ancona G, Elstad M, Green L, Fernandes M, Thomson L, Roxas C, Dhariwal J, Nanzer AM, Kent BD, Jackson DJ., Real-World Effectiveness and the Characteristics of a "Super-Responder" to Mepolizumab in Severe Eosinophilic Asthma., Chest, 158, (2), 2020, p491-500 Journal Article, 2020 DOI

Wimms AJ, Kelly JL, Turnbull CD, McMillan A, Craig SE, O'Reilly JF, Nickol AH, Hedley EL, Decker MD, Willes LA, Calverley PMA, Benjafield AV, Stradling JR, Morrell MJ, MERGE trial investigators., Continuous positive airway pressure versus standard care for the treatment of people with mild obstructive sleep apnoea (MERGE): a multicentre, randomised controlled trial., The Lancet. Respiratory medicine, 8, (4), 2020, p349-358 Journal Article, 2020 DOI

Nanzer AM, Chowdhury A, Raheem A, Roxas C, Fernandes M, Thomson L, Green L, Dhariwal J, D'Ancona G, Kent BD, Kelly PA, Jackson DJ., Prevalence and recovery of adrenal insufficiency in steroid-dependent asthma patients receiving biologic therapy., The European respiratory journal, 56, (1), 2020 Journal Article, 2020 DOI

d'Ancona G, Kavanagh J, Roxas C, Green L, Fernandes M, Thomson L, Dhariwal J, Nanzer AM, Jackson DJ, Kent BD., Adherence to corticosteroids and clinical outcomes in mepolizumab therapy for severe asthma., The European respiratory journal, 55, (5), 2020 Journal Article, 2020 DOI

Kent BD, d'Ancona G, Fernandes M, Green L, Roxas C, Thomson L, Nanzer AM, Kavanagh J, Agarwal S, Jackson DJ., Oral corticosteroid-sparing effects of reslizumab in the treatment of eosinophilic granulomatosis with polyangiitis., ERJ open research, 6, (1), 2020 Journal Article, 2020 DOI

Hearn AP, Kent BD, Jackson DJ., Biologic treatment options for severe asthma., Current opinion in immunology, 66, 2020, p151-160 Journal Article, 2020 DOI

Patel S, Shah NM, Malhotra AM, Lockie C, Camporota L, Barrett N, Kent BD, Jackson DJ., Inflammatory and microbiological associations with near-fatal asthma requiring extracorporeal membrane oxygenation., ERJ open research, 6, (1), 2020 Journal Article, 2020 DOI

Fotis Sakellariou D, Nesbitt AD, Higgins S, Beniczky S, Rosenzweig J, Drakatos P, Gildeh N, Murphy PB, Kent B, Williams AJ, Kryger M, Goadsby PJ, Leschziner GD, Rosenzweig I., Co-activation of rhythms during alpha band oscillations as an interictal biomarker of exploding head syndrome., Cephalalgia : an international journal of headache, 40, (9), 2020, p949-958 Journal Article, 2020 DOI

Nanzer AM, Dhariwal J, Kavanagh J, Hearn A, Fernandes M, Thomson L, Roxas C, Green L, D'Ancona G, Agarwal S, Kent BD, Jackson DJ., Steroid-sparing effects of benralizumab in patients with eosinophilic granulomatosis with polyangiitis., ERJ open research, 6, (4), 2020 Journal Article, 2020 DOI

Kavanagh JE, Hearn AP, d'Ancona G, Dhariwal J, Roxas C, Green L, Thomson L, Fernandes M, Kent BD, Nanzer AM, Jackson DJ., Benralizumab after sub-optimal response to mepolizumab in severe eosinophilic asthma., Allergy, 2020 Journal Article, 2020 DOI

Crinion SJ, Tiron R, Lyon G, Zaffaroni A, Kilroy H, Doheny E, O'Hare E, Boyle P, Russell A, Traynor M, Kent BD, Ryan S, McNicholas WT., Ambulatory detection of sleep apnea using a non-contact biomotion sensor., Journal of sleep research, 29, (1), 2020, pe12889 Journal Article, 2020 DOI

Drakatos P, Marples L, Muza R, Higgins S, Nesbitt A, Dongol EM, Macavei R, Gnoni V, Perez Carbonell L, Duncan I, Birdseye A, Dastagir S, Rosenzweig I, O'Regan D, Williams AJ, Leschziner GD, Kent BD., Video polysomnographic findings in non-rapid eye movement parasomnia., Journal of sleep research, 28, (2), 2019, pe12772 Journal Article, 2019 DOI

Kavanagh J, Jackson DJ, Kent BD., Over- and under-diagnosis in asthma., Breathe (Sheffield, England), 15, (1), 2019, pe20-e27 Journal Article, 2019 DOI

He B, Al-Sherif M, Nido M, Tas R, Beach M, Schwarz EI, Cheng M, Ishak A, Lee K, Shah N, Kent B, Eze-John P, Ratneswaran C, Rafferty G, Williams AJ, Hart N, Luo Y, Moxham J, Pengo M, Steier J., Domiciliary use of transcutaneous electrical stimulation for patients with obstructive sleep apnoea: a conceptual framework for the TESLA home programme., Journal of thoracic disease, 11, (5), 2019, p2153-2164 Journal Article, 2019 DOI

Sleep Disordered Breathing. in, editor(s)Jonathan Cousins, Christopher Bouch , Core Topics in Anaesthesia for the Morbidly Obese Surgical Patient. , Cambridge University Press, 2019, [Kent BD, Steier JS] Book Chapter, 2019

Myall KJ, West A, Kent BD., Sleep and interstitial lung disease., Current opinion in pulmonary medicine, 25, (6), 2019, p623-628 Journal Article, 2019 DOI

Drakatos P, Marples L, Muza R, Higgins S, Gildeh N, Macavei R, Dongol EM, Nesbitt A, Rosenzweig I, Lyons E, d'Ancona G, Steier J, Williams AJ, Kent BD, Leschziner G., NREM parasomnias: a treatment approach based upon a retrospective case series of 512 patients., Sleep medicine, 53, 2019, p181-188 Journal Article, 2019 DOI

Crinion SJ, Ryan S, Kleinerova J, Kent BD, Gallagher J, Ledwidge M, McDonald K, McNicholas WT., Nondipping Nocturnal Blood Pressure Predicts Sleep Apnea in Patients With Hypertension., Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 15, (7), 2019, p957-963 Journal Article, 2019 DOI

Marrone O, Cibella F, Pépin JL, Grote L, Verbraecken J, Saaresranta T, Kvamme JA, Basoglu OK, Lombardi C, McNicholas WT, Hedner J, Bonsignore MR, ESADA Network., Fixed But Not Autoadjusting Positive Airway Pressure Attenuates the Time-dependent Decline in Glomerular Filtration Rate in Patients With OSA., Chest, 154, (2), 2018, p326-334 Journal Article, 2018 DOI

Pengo MF, Czaban M, Berry MP, Nirmalan P, Brown R, Birdseye A, Woroszyl A, Chapman J, Kent BD, Hart N, Rossi GP, Steier J., The effect of positive and negative message framing on short term continuous positive airway pressure compliance in patients with obstructive sleep apnea., Journal of thoracic disease, 10, (suppl 1), 2018, pS160-S169 Journal Article, 2018 DOI

Thakrar C, Patel K, D'ancona G, Kent BD, Nesbitt A, Selsick H, Steier J, Rosenzweig I, Williams AJ, Leschziner GD, Drakatos P., Effectiveness and side-effect profile of stimulant therapy as monotherapy and in combination in the central hypersomnias in clinical practice., Journal of sleep research, 27, (4), 2018, pe12627 Journal Article, 2018 DOI

Mandal S, Kent BD., Obstructive sleep apnoea and coronary artery disease., Journal of thoracic disease, 10, (suppl 34), 2018, pS4212-S4220 Journal Article, 2018 DOI

Kavanagh J, Jackson DJ, Kent BD., Sleep and asthma., Current opinion in pulmonary medicine, 24, (6), 2018, p569-573 Journal Article, 2018 DOI

Gündüz C, Basoglu OK, Hedner J, Zou D, Bonsignore MR, Hein H, Staats R, Pataka A, Barbe F, Sliwinski P, Kent BD, Pepin JL, Grote L, European Sleep Apnea Database Collaborators., Obstructive sleep apnoea independently predicts lipid levels: Data from the European Sleep Apnea Database., Respirology (Carlton, Vic.), 23, (12), 2018, p1180-1189 Journal Article, 2018 DOI

Drakatos P, Lykouras D, D'Ancona G, Higgins S, Gildeh N, Macavei R, Rosenzweig I, Steier J, Williams AJ, Muza R, Kent BD, Leschziner G., Safety and efficacy of long-term use of sodium oxybate for narcolepsy with cataplexy in routine clinical practice., Sleep medicine, 35, 2017, p80-84 Journal Article, 2017 DOI

Bisogni V, Pengo MF, Drakatos P, Maiolino G, Kent B, Rossitto G, Steier J, Rossi GP., Excessive daytime sleepiness does not correlate with sympathetic nervous system activation and arterial stiffening in patients with mild-to-moderate obstructive sleep apnoea: A proof-of-principle study., International journal of cardiology, 236, 2017, p458-461 Journal Article, 2017 DOI

Murphy AM, Thomas A, Crinion SJ, Kent BD, Tambuwala MM, Fabre A, Pepin JL, Roche HM, Arnaud C, Ryan S., Intermittent hypoxia in obstructive sleep apnoea mediates insulin resistance through adipose tissue inflammation., The European respiratory journal, 49, (4), 2017 Journal Article, 2017 DOI

Bisogni V, Pengo MF, Drakatos P, Maiolino G, Kent B, Rossitto G, Steier J, Rossi GP., Excessive daytime sleepiness, sympathetic nervous system activation and arterial stiffening in patients with mild-to-moderate obstructive sleep apnoea. Reply., International journal of cardiology, 249, 2017, p415-416 Journal Article, 2017 DOI

Drakatos P, Higgins S, Duncan I, Stevens S, Dastagir S, Birdseye A, Lykouras D, Muza R, Gildeh N, Rosenzweig I, Williams AJ, Leschziner GD, Kent BD., Catathrenia, a REM predominant disorder of arousal?, Sleep medicine, 32, 2017, p222-226 Journal Article, 2017 DOI

Drakatos P, Kent BD, Birdseye A, Dastagir S, Higgins S, Williams AJ, Leschziner G., Phasic activity and the importance of irregular breathing., Sleep medicine, 38, 2017, p21-23 Journal Article, 2017 DOI

Gildeh N, Rosenzweig I, Kent BD., Lessons from randomised controlled trials of continuous positive airways pressure therapy in the prevention of cardiovascular morbidity and mortality., Journal of thoracic disease, 9, (2), 2017, p244-246 Journal Article, 2017 DOI

Drakatos P, Patel K, Thakrar C, Williams AJ, Kent BD, Leschziner GD., Sleep-stage sequencing of sleep-onset REM periods in MSLT predicts treatment response in patients with narcolepsy., Journal of sleep research, 25, (2), 2016, p203-210 Journal Article, 2016 DOI

Gildeh N, Drakatos P, Higgins S, Rosenzweig I, Kent BD., Emerging co-morbidities of obstructive sleep apnea: cognition, kidney disease, and cancer., Journal of thoracic disease, 8, (9), 2016, pE901-E917 Journal Article, 2016 DOI

Drakatos P, Higgins S, Duncan I, Bridle K, Briscoe S, Leschziner GD, Kent BD, Williams AJ., The utility of respiratory inductance plethysmography in REM sleep scoring during multiple sleep latency testing., Respiratory physiology & neurobiology, 230, 2016, p1-4 Journal Article, 2016 DOI

Drakatos P, Higgins S, Pengo MF, Kent BD, Muza R, Karkoulias K, Leschziner G, Williams A., Derived Arterial Stiffness is Increased in Patients with Obstructive Sleep Apnea and Periodic Limb Movements during Sleep., Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 12, (2), 2016, p195-202 Journal Article, 2016 DOI

Pengo MF, Ratneswaran C, Berry M, Kent BD, Kohler M, Rossi GP, Steier J., Effect of Continuous Positive Airway Pressure on Blood Pressure Variability in Patients With Obstructive Sleep Apnea., Journal of clinical hypertension (Greenwich, Conn.), 18, (11), 2016, p1180-1184 Journal Article, 2016 DOI

Kent BD, McNicholas WT, Ryan S., Insulin resistance, glucose intolerance and diabetes mellitus in obstructive sleep apnoea., Journal of thoracic disease, 7, (8), 2015, p1343-1357 Journal Article, 2015 DOI

Kent BD, Steier J., A brief history of fluid and sleep., American journal of respiratory and critical care medicine, 191, (11), 2015, p1219-1220 Journal Article, 2015 DOI

Gaoatswe G, Kent BD, Corrigan MA, Nolan G, Hogan AE, McNicholas WT, O'Shea D., Invariant Natural Killer T Cell Deficiency and Functional Impairment in Sleep Apnea: Links to Cancer Comorbidity., Sleep, 38, (10), 2015, p1629-1634 Journal Article, 2015 DOI

Garvey JF, Pengo MF, Drakatos P, Kent BD., Epidemiological aspects of obstructive sleep apnea., Journal of thoracic disease, 7, (5), 2015, p920-929 Journal Article, 2015 DOI

Kent BD, Grote L, Bonsignore MR, Saaresranta T, Verbraecken J, Lévy P, Sliwinski P, Tkacova R, Kvamme JA, Fietze I, Hedner J, McNicholas WT, European Sleep Apnoea Database collaborators., Sleep apnoea severity independently predicts glycaemic health in nondiabetic subjects: the ESADA study., The European respiratory journal, 44, (1), 2014, p130-139 Journal Article, 2014 DOI

Pallin M, O'Hare E, Zaffaroni A, Boyle P, Fagan C, Kent B, Heneghan C, de Chazal P, McNicholas WT., Comparison of a novel non-contact biomotion sensor with wrist actigraphy in estimating sleep quality in patients with obstructive sleep apnoea., Journal of sleep research, 23, (4), 2014, p475-484 Journal Article, 2014 DOI

Kent BD, Lane SJ, van Beek EJ, Dodd JD, Costello RW, Tiddens HA., Asthma and cystic fibrosis: a tangled web., Pediatric pulmonology, 49, (3), 2014, p205-213 Journal Article, 2014 DOI

Taylor CT, Kent BD, Crinion SJ, McNicholas WT, Ryan S., Human adipocytes are highly sensitive to intermittent hypoxia induced NF-kappaB activity and subsequent inflammatory gene expression., Biochemical and biophysical research communications, 447, (4), 2014, p660-665 Journal Article, 2014 DOI

Chong SG, Kent BD, Fitzgerald S, McDonnell TJ., Pulmonary non-tuberculous mycobacteria in a general respiratory population., Irish medical journal, 107, (7), 2014, p207-209 Journal Article, 2014 DOI

Kent BD, Grote L, Ryan S, Pépin JL, Bonsignore MR, Tkacova R, Saaresranta T, Verbraecken J, Lévy P, Hedner J, McNicholas WT., Diabetes mellitus prevalence and control in sleep-disordered breathing: the European Sleep Apnea Cohort (ESADA) study., Chest, 146, (4), 2014, p982-990 Journal Article, 2014 DOI

Zaffaroni A, Kent B, O'Hare E, Heneghan C, Boyle P, O'Connell G, Pallin M, de Chazal P, McNicholas WT., Assessment of sleep-disordered breathing using a non-contact bio-motion sensor., Journal of sleep research, 22, (2), 2013, p231-236 Journal Article, 2013 DOI

Kent BD, Garvey JF, Ryan S, Nolan G, Dodd JD, McNicholas WT., Severity of obstructive sleep apnoea predicts coronary artery plaque burden: a coronary computed tomographic angiography study., The European respiratory journal, 42, (5), 2013, p1263-1270 Journal Article, 2013 DOI

Kent, B.D., Lane, S.J., Moloney, E.D., Asthma admissions, smoking bans and administrative databases, Thorax, 68, (12), 2013, p1166 Journal Article, 2013

The genetics of obstructive sleep apnoea. in, editor(s)Michael Murray, Mark Babayatski, Monica Giovanni , ACP Clinical Genomics. , McGraw-Hill, 2013, [Kent BD, Ryan S, McNicholas WT] Book Chapter, 2013

Kent BD, Eltayeb EE, Woodman A, Mutwali A, Nguyen HT, Stack AG., The impact of chronic obstructive pulmonary disease and smoking on mortality and kidney transplantation in end-stage kidney disease., American journal of nephrology, 36, (3), 2012, p287-295 Journal Article, 2012 DOI

Kent BD, McNicholas WT, Verbraecken J., Disturbed sleep and COPD outcomes: cart meets horse., Sleep medicine, 13, (5), 2012, p453-454 Journal Article, 2012 DOI

Kent BD, Lane SJ., Twin epidemics: asthma and obesity., International archives of allergy and immunology, 157, (3), 2012, p213-214 Journal Article, 2012 DOI

Questionnaires in Respiratory Sleep Medicine. in, editor(s)Anita Simonds, Wilifred de Backer , ERS Handbook of Respiratory Sleep Medicine. , European Respiratory Society , 2012, [Kent BD, McNicholas WT] Book Chapter, 2012

Fitzgerald DB, Kent BD, Garvey JF, Russell A, Nolan G, McNicholas WT., Screening for diabetes mellitus in patients with OSAS: a case for glycosylated haemoglobin., The European respiratory journal, 40, (1), 2012, p273-274 Journal Article, 2012 DOI

Kent, B.D., Sulaiman, I., Nicholson, T.T., Lane, S.J., Moloney, E.D., Acute pulmonary admissions following implementation of a national workplace smoking ban, Chest, 142, (3), 2012, p673-679 Journal Article, 2012

Kent, B.D., Nadarajan, P., Akasheh, N.B., Sulaiman, I., Karim, S., Cooney, S., Lane, S.J., Moloney, E.D., Improving venous thromboembolic disease prophylaxis in medical inpatients: A role for education and audit, Irish Journal of Medical Science, 180, (1), 2011, p163-166 Journal Article, 2011

Kent B.D., McNicholas W.T., Ambulatory investigation of sleep-disordered breathing, Breathe, 8, (2), 2011, p107 - 112, p107-112 Journal Article, 2011 DOI

Kent BD, Sulaiman I, Akasheh NB, Nadarajan P, Moloney E, Lane SJ, An unusual cause of spontaneous pneumothorax: the Mounier-Kuhn syndrome., Irish medical journal, 2011 Journal Article, 2011

Kent BD, Ryan S, McNicholas WT., Obstructive sleep apnea and inflammation: relationship to cardiovascular co-morbidity., Respiratory physiology & neurobiology, 178, (3), 2011, p475-481 Journal Article, 2011 DOI

Kent BD, Mitchell PD, McNicholas WT., Hypoxemia in patients with COPD: cause, effects, and disease progression., International journal of chronic obstructive pulmonary disease, 6, 2011, p199-208 Journal Article, 2011 DOI

Kent BD, Lane SJ., Lung cancer--perceptual barriers to cure., Irish medical journal, 103, (8), 2010, p229 Journal Article, 2010 DOI

Kent BD, Ryan S, McNicholas WT., The genetics of obstructive sleep apnoea., Current opinion in pulmonary medicine, 16, (6), 2010, p536-542 Journal Article, 2010 DOI

Overview of basic mechanisms of cardiovascular disease in OSA in, European Respiratory Monograph Vol 50, European Respiratory Society, 2010, pp340 - 359, [Kent BD, McNicholas WT] Book Chapter, 2010

Nadarajan, P., Sulaiman, I., Kent, B., Breslin, N., Moloney, E.D., Lane, S.J., Endoscopic ultrasound with fine needle aspiration and biopsy in lung cancer and isolated mediastinal lymphadenopathy, Irish Medical Journal, 103, (3), 2010 Journal Article, 2010

Research Expertise

Description

My research interests include: . How patient behaviours influence disease activity and responses to medical therapy. In particular, how adherence to prescribed treatment can modify outcomes in chronic respiratory and sleep disorders. . The use of biomarkers to guide disease management in people with difficult and severe asthma. . Real world outcomes with targeted biological therapies in severe asthma. . Interactions between sleep disorders & respiratory disease (including COVID-19) in disease outcomes and patient-reported symptom burden. . The clinical management of hitherto under-investigated sleep disorders, including Non-REM sleep parasomnias. . The use of anti-eosinophil biologic agents in the treatment of Eosinophilic Granulomatosis with Polyangiitis.

Recognition

Representations

Chief Editor-elect, Breathe September 2021

Secretary, Irish Sleep Society 2021

Section editor on Sleep Disorders, Current Opinion in Pulmonary Medicine 2016-2019

Memberships

European Respiratory Society

Irish Thoracic Society

British Thoracic Society

American Thoracic Society

Irish Sleep Society

British Sleep Society

American College of Chest Physicians