Dr. Hugh Kearney
Clinical Senior Lecturer, Clinical Medicine
Biography
Dr Kearney completed a PhD in University College London investigating the use of spinal cord MRI in MS and its association with disability. He completed his clinical training in neurology in Ireland, including a two-year postdoctoral fellowship in genomics with FutureNeuro. He currently works as a consultant neurologist in St James's Hospital, and is leading the newly established MS unit. He is also part of the Academic Unit of Neurology in Trinity College Dublin, and is developing a research group focused on translational research in multiple sclerosis, including the development of diagnostic biomarkers.
Publications and Further Research Outputs
Peer-Reviewed Publications
Siew Mei Yap and Laura Davenport and Clodagh Cogley and Fiona Craddock and Alex Kennedy and Maria Gaughan and Hugh Kearney and Niall Tubridy and Cé, Word finding, prosody and social cognition in multiple sclerosis, Journal of Neuropsychology, 2022
Valsasina P, Gobbi C, Zecca C, Rovira A, Sastre-Garriga J, Kearney H, Yiannakas M, Matthews L, Palace J, Gallo A, Bisecco A, Gass A, Eisele P, Filippi M, Rocca MA, MAGNIMS Study Group;., Characterizing 1-year development of cervical cord atrophy across different MS phenotypes: A voxel-wise, multicentre analysis., Multiple sclerosis (Houndmills, Basingstoke, England), 28, (6), 2022, p885-899
Schwarz, N., Seiffert, S., Pendziwiat, M., Rademacher, A., Brünger, T., Hedrich, U.B.S., Augustijn, P.B., Baier, H., Bayat, A., Bisulli, F., Buono, R.J., Bruria, B.Z., Doyle, M.G., Guerrini, R., Heimer, G., Iacomino, M., Kearney, H., Klein, K.M., Kousiappa, I., Kunz, W.S., Lerche, H., Licchetta, L., Lohmann, E., Minardi, R., McDonald, M., Montgomery, S., Mulahasanovic, L., Oegema, R., Ortal, B., Papacostas, S.S., Ragona, F., Granata, T., Reif, P.S., Rosenow, F., Rothschild, A., Scudieri, P., Striano, P., Tinuper, P., Tanteles, G.A., Vetro, A., Zahnert, F., Zara, F., Lal, D., May, P., Muhle, H., Helbig, I., Weber, Y., Heterozygous variants in KCNC2 cause a broad spectrum of epilepsy phenotypes associated with characteristic functional alterations, medRxiv, 2021
, Vaccine hesitancy among people with multiple sclerosis., Multiple sclerosis and related disorders, 2021
, The Human Phenotype Ontology in 2021., Nucleic acids research, 2021
David Lewis"Smith, Peter D. Galer, Ganna Balagura, Hugh Kearney, Shiva Ganesan, Mahgenn Cosico, Margaret O'Brien, Priya Vaidiswaran, Roland Krause, Colin A. Ellis, Rhys H. Thomas, Peter N. Robinson, Ingo Helbig, Modeling seizures in the Human Phenotype Ontology according to contemporary ILAE concepts makes big phenotypic data tractable, Epilepsia, 62, (6), 2021, p1293--1305
Rocca MA, Valsasina P, Meani A, Gobbi C, Zecca C, Rovira A, Sastre-Garriga J, Kearney H, Ciccarelli O, Matthews L, Palace J, Gallo A, Bisecco A, Lukas C, Bellenberg B, Barkhof F, Vrenken H, Preziosa P, Filippi M, MAGNIMS Study Group., Association of Gray Matter Atrophy Patterns With Clinical Phenotype and Progression in Multiple Sclerosis., Neurology, 96, (11), 2021, pe1561-e1573
Siew Mei Yap, Mark S. Etzelmueller, Clodagh O'Keeffe, Maria Gaughan, Hugh Kearney, Niall Tubridy, Richard B. Reilly, Christopher McGuigan, Postural stability is a valid and meaningful disability metric in progressive MS with potential for use in neuroprotective therapy trials, Multiple Sclerosis and Related Disorders, 52, 2021, p102946
Togher Z, Fullam S, Callanan I, Kearney H, Tubridy N., An evaluation of optimal tutorial methodologies for neurology teaching at undergraduate level : Optimal tutorial methods for neurology., Ir J Med Sci, 190, (3), 2021, p965-969
, Location-specific reflex epilepsy: a novel reflex epilepsy phenotype., Epilepsy & behavior reports, 2020
Benson KA, White M, Allen NM, Byrne S, Carton R, Comerford E, Costello D, Doherty C, Dunleavey B, El-Naggar H, Gangadharan N, Heavin S, Kearney H, Cavalleri GL, A comparison of genomic diagnostics in adults and children with epilepsy and comorbid intellectual disability., European journal of human genetics : EJHG, 2020
McCrea Z, Power K, Kiersey R, White M, Breen A, Murphy S, Healy L, Kearney H, Dunleavy B, O'Donoghue S, Lambert V, Delanty N, Doherty C, Fitzsimons M, Coproducing health and well-being in partnership with patients, families, and healthcare providers: A qualitative study exploring the role of an epilepsy patient portal., Epilepsy & behavior : E&B, 2020
Al Hussona M, Kearney H, Fisher A, Lynch J, Looby S, Delanty N., New onset seizures as a sole clinical presentation of multiple sclerosis., Multiple sclerosis (Houndmills, Basingstoke, England), 25, (2), 2019, p295-299
, Spatial distribution of multiple sclerosis lesions in the cervical spinal cord., Brain : a journal of neurology, 2019
Hugh Kearney, Tucker Price, Jane Cryan, Alan Beausang, Seamus Looby, Francesca M. Brett, Michael Farrell, Acute multiple sclerosis lesion pathology does not predict subsequent clinical course"a biopsy study, Irish Journal of Medical Science (1971 -), 188, (4), 2019, p1427--1434
Elseed M, Baheerathan A, Kearney H, Abkur T., Reversible splenial lesion syndrome., British journal of hospital medicine (London, England : 2005), 80, (12), 2019, p734-735
Kearney H, Byrne S, Cavalleri GL, Delanty N., Tackling Epilepsy With High-definition Precision Medicine: A Review., JAMA neurology, 76, (9), 2019, p1109-1116
Kearney H., Reader response: Subcutaneous ofatumumab in patients with relapsing-remitting multiple sclerosis: The MIRROR study., Neurology, 92, (11), 2019, p542-543
Rocca MA, Valsasina P, Meani A, Gobbi C, Zecca C, Rovira À, Montalban X, Kearney H, Ciccarelli O, Matthews L, Palace J, Gallo A, Bisecco A, Gass A, Eisele P, Lukas C, Bellenberg B, Barkhof F, Vrenken H, Preziosa P, Comi G, Filippi M, MAGNIMS Study Group., Clinically relevant cranio-caudal patterns of cervical cord atrophy evolution in MS., Neurology, 93, (20), 2019, pe1852-e1866
Lorigan J, Kearney H, Grimes B, Heffernan J, Beausang A, Cryan J, Farrell MA, Brett FM., Evaluation of the specificity of the central diagnostic criterion for chronic traumatic encephalopathy., Ir J Med Sci, 188, (3), 2019, p993-998
Cahalane AM, Kearney H, Purcell YM, McGuigan C, Killeen RP., MRI and multiple sclerosis--the evolving role of MRI in the diagnosis and management of MS: the radiologist's perspective., Ir J Med Sci, 187, (3), 2018, p781-787
Kearney H, Beausang A., A 3-year old female with an atypical pineal tumor., Clinical neuropathology, 37, (3), 2018, p156-158
Gros, C., de Leener, B., Badji, A., Maranzano, J., Eden, D., Dupont, S.M., Talbott, J., Zhuoquiong, R., Liu, Y., Granberg, T., Ouellette, R., Tachibana, Y., Hori, M., Kamiya, K., Chougar, L., Stawiarz, L., Hillert, J., Bannier, E., Kerbrat, A., Edan, G., Labauge, P., Callot, V., Pelletier, J., Audoin, B., Rasoanandrianina, H., Brisset, J.-C., Valsasina, P., Rocca, M.A., Filippi, M., Bakshi, R., Tauhid, S., Prados, F., Yiannakas, M., Kearney, H., Ciccarelli, O., Smith, S., Treaba, C.A., Mainero, C., Lefeuvre, J., Reich, D.S., Nair, G., Auclair, V., McLaren, D.G., Martin, A.R., Fehlings, M.G., Vahdat, S., Khatibi, A., Doyon, J., Shepherd, T., Charlson, E., Narayanan, S., Cohen-Adad, J., Automatic segmentation of the spinal cord and intramedullary multiple sclerosis lesions with convolutional neural networks, arXiv, 2018
Kearney H, Cryan JB, Looby S, Brett FM, Farrell MA, Buckley PG., The DNA copy number landscape of a collision tumor., Clinical neuropathology, 37, (2), 2018, p68-73
Abkur TM, Kearney H, Hennessy MJ., Refractory epilepsy following natalizumab associated PML., Multiple sclerosis and related disorders, 20, 2018, p1-2
Cawley N, Tur C, Prados F, Plantone D, Kearney H, Abdel-Aziz K, Ourselin S, Wheeler-Kingshott CAG, Miller DH, Thompson AJ, Ciccarelli O., Spinal cord atrophy as a primary outcome measure in phase II trials of progressive multiple sclerosis., Multiple sclerosis (Houndmills, Basingstoke, England), 24, (7), 2018, p932-941
O'Regan CJ, Kearney H, Beausang A, Farrell MA, Brett FM, Cryan JB, Loftus TE, Buckley PG., Temporal stability of MGMT promoter methylation in glioblastoma patients undergoing STUPP protocol., Journal of neuro-oncology, 137, (2), 2018, p233-240
de Looze, C. and Beausang, A. and Cryan, J. and Loftus, T. and Buckley, P.G. and Farrell, M. and Looby, S. and Reilly, R. and Brett, F. and Kearney, H., Machine learning: a useful radiological adjunct in determination of a newly diagnosed gliomaâ s grade and IDH status, Journal of Neuro-Oncology, 2018, p491-499
Kearney H., Clinical monitoring of multiple sclerosis should routinely include spinal cord imaging - No., Multiple sclerosis (Houndmills, Basingstoke, England), 24, (12), 2018, p1537-1539
Kearney H, Cahalane AM, Killeen RP, McGuigan C., MRI and multiple sclerosis-the evolving role of MRI in the diagnosis and management of MS: a clinician's perspective., Ir J Med Sci, 187, (2), 2018, p493-498
Hugh Kearney, Jane Cryan, Alan Beausung, Seamus Looby, Francesca M. Brett, Reactive gliosis mimicking tumor recurrence " a case series documenting MRI abnormalities and neuropathological correlates, Clinical Neuropathology, 37, (05), 2018, p97--104
Kearney, H., Cahalane, A.M., Killeen, R.P., McGuigan, C., Correction to: MRI and multiple sclerosis"the evolving role of MRI in the diagnosis and management of MS: a clinician"s perspective (Irish Journal of Medical Science (1971), (2018), 187, 2, (493-498), 10.1007/s11845-017-1691-z), Irish Journal of Medical Science, 187, (2), 2018, p499
Brett FM, Looby S, Chalissery A, Chen D, Heaney C, Heffernan J, Cunningham F, Howley R, Loftus T, Kearney H, Farrell MA., Brain biopsies requiring Creutzfeldt-Jakob disease precautions in the Republic of Ireland 2005-2016., Ir J Med Sci, 187, (2), 2018, p515-520
Francesca M. Brett, Hugh Kearney, Neuropathology correlates of cognitive assessments, Irish Journal of Medical Science (1971 -), 187, (3), 2018, p835--844
Frazer B, Kearney H, Cryan J, Beausang A, Brett F, Farrell MA, Buckley PG., Absence of 1p/19q codeletion in oligodendroglioma-like areas of pilocytic astrocytomas., Clinical neuropathology, 37, (4), 2018, p182-185
, Automatic segmentation of the spinal cord and intramedullary multiple sclerosis lesions with convolutional neural networks., NeuroImage, 2018
Kearney H, Cahalane AM, Killeen RP, McGuigan C., Correction to: MRI and multiple sclerosis-the evolving role of MRI in the diagnosis and management of MS: a clinician's perspective., Ir J Med Sci, 187, (2), 2018, p499
Abkur TM, Kearney H, Hennessy MJ., CLIPPERS and the need for long-term immunosuppression., Scottish medical journal, 62, (1), 2017, p28-33
Kearney H, Krakar A, Drazyk A, Maloney E, Callinan I, Tubridy N., An Audit of the Effectiveness of Large Group Neurology Tutorials for Irish Undergraduate Medical Students., Irish medical journal, 109, (7), 2016, p438
Kearney, H., Krakar, A., Drazyk, A., Maloney, E., Callanan, I., Tubridy, N., An audit of the effectiveness of large group neurology tutorials for irish undergraduate medical students, Irish Medical Journal, 109, (7), 2016, p438
Kearney H, Miszkiel KA, Yiannakas MC, Altmann DR, Ciccarelli O, Miller DH., Grey matter involvement by focal cervical spinal cord lesions is associated with progressive multiple sclerosis., Multiple sclerosis (Houndmills, Basingstoke, England), 22, (7), 2016, p910-920
, Fully automated grey and white matter spinal cord segmentation., Scientific reports, 2016
Abkur TM, Foran E, Kearney H, Harkin G, Byrnes V, Lynch J., Neuromyelitis optica presenting as intractable vomiting and hyperCKaemia., Journal of neurology, 263, (1), 2016, p171-173
, Fully automated segmentation of the cervical cord from T1-weighted MRI using PropSeg: Application to multiple sclerosis., NeuroImage. Clinical, 2015
Kearney H, Miller DH, Ciccarelli O., Spinal cord MRI in multiple sclerosis--diagnostic, prognostic and clinical value., Nature reviews. Neurology, 11, (6), 2015, p327-338
, Getting a handle on complicated migraine., BMJ case reports, 2015
Yiannakas MC, Kearney H, Samson RS, Chard DT, Ciccarelli O, Miller DH, Wheeler-Kingshott CA., Feasibility of grey matter and white matter segmentation of the upper cervical cord in vivo: a pilot study with application to magnetisation transfer measurements., NeuroImage, 63, (3), 2012, p1054-1059
Kearney H, O'Dowd S, Murray B, Kavanagh E, O'Connell M, Lynch T., Re-emergence of artistic traits in a patient with frontotemporal dementia., Clinical neurology and neurosurgery, 114, (4), 2012, p417-420
Kearney H, Murray B, Kavanagh E, O'Rourke K, Kelly P, Lynch T., Autoimmune encephalopathy presenting as a 'posterior circulation stroke'., Journal of neurology, 258, (2), 2011, p330-332
Kearney H, Mallon P, Kavanagh E, Lawler L, Kelly P, O'Rourke K., Amnestic syndrome due to meningovascular neurosyphilis., Journal of neurology, 257, (4), 2010, p669-671
Kearney, H., Delanty, N., Felbamate in an adult population with severe refractory epilepsy, Irish Medical Journal, 102, (10), 2009
, The patient knows best: significant change in the physical component of the Multiple Sclerosis Impact Scale (MSIS-29 physical)., Journal of neurology, neurosurgery, and psychiatry, 2007
Research Expertise
Description
I am a neurologist working in St James's Hospital and run the multiple sclerosis (MS) service. Arising from my clinical work my research interests are based in MS and link to clinical observations. There are two research priorities that my work focuses on: delay to diagnosis and misdiagnosis. To address these problems I am developing new diagnostic biomarkers through clinically based research.Recognition
Awards and Honours
Harold Miller Prize at INA
Harold Miller Prize at INA
Neuropathology fellowship award
Memberships
Irish Institute of Clinical Neuroscience
American Academy of Neurology
European Academy of Neurology