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Professor John Nolan
Adjunct Professor, Clinical Medicine
Associate Prof in Endocrinology, Biochemistry

Publications and Further Research Outputs

Peer-Reviewed Publications

María Isabel Hernández, Hood Thabit, Nicole Burns, Syed Shah, Imad Brema, Mensud Hatunic, Francis Finucane, , Marc Liesa, Chiara Chiellini, Deborah Naon, Antonio Zorzano and John J. Nolan, Subjects with early-onset type 2 diabetes show defective activation of the skeletal muscle PGC-1 Ñ/mitofusin-2 regulatory pathway in response to physical activity, Diabetes Care, 33, (3), 2010, p645 - 651 Journal Article, 2010

Kozàkovà M, Palombo C, Morizzo C, Nolan JJ, Balkau B and the RISC investigators, Effect of sedentary behavior and vigorous physical activity on segment-specific carotid wall thickness and its progression in a healthy population., European Heart Journal, 2010 Journal Article, 2010

Hatunic M, Finucane FM, Brennan AM, Norris S, Pacini G, Nolan JJ , Effect of Iron Overload on Glucose Metabolism in Patients with Hereditary Haemochromatosis, Metabolism, 59, (3), 2010, p380 - 384 Journal Article, 2010

Stone MA, Wilkinson JC, Charpentier G, Clochard N, Lindblad U, Müller UA, Nolan J, Rutten GE, Trento M, Khunti K, Evaluation and comparison of guidelines for the management of people with type 2 diabetes from eight European countries, Diabetes Research and Clinical Practice, 87, (2), 2010, p252 - 260 Journal Article, 2010

H Thabit, S Shah, M Nash, I Brema, JJ Nolan and G Martin, Globalisation, Immigration and Diabetes Self-Management: An Empirical Study , Quarterly Journal of Medicine, 102, (10), 2009, p713 - 720 Journal Article, 2009

Hatunic M, Stapleton M, Hand E, De Long C, Crowley VE, Nolan JJ, The Leu262Val polymorphism of presenilin associated rhomboid like protein (PARL) is associated with earlier onset of type 2 diabetes and increased urinary microalbumin creatinine ratio in an Irish case-control population, Diabetes Research and Clinical Practice, 83, (3), 2009, p316 - 319 Journal Article, 2009

Susanne R. de Rooij, PhD1, Giel Nijpels, MD, PhD1, Peter M. Nilsson, MD, PhD2, John J. Nolan, MD3, Rafael Gabriel, MD, PhD4, Elisabetta Bobbioni-Harsch, PhD5, Geltrude Mingrone, MD, PhD6, Jacqueline M. Dekker, PhD1, and the RISC Investigators. , Low grade chronic inflammation in the RISC population:, Diabetes Care, 32, (7), 2009, p1295 - 1301 Journal Article, 2009

Siobhan Bacon¹, Matthew Murphy², Kavita Pannu¹, Nuala Murphy³, John J Nolan², Maria M Byrne¹. , Phenotypic variability between and within MODY 3 pedigrees, Pediatric Diabetes, 2009 Journal Article, 2009

F.M. Finucane1*, J. Luan1*,N.J. Wareham1, S. O'Rahilly2, B. Balkau3, A. Flyvbjerg4, , Correlation of the leptin: adiponectin ratio with measures of insulin resistance in non-diabetic individuals, Diabetologia, 52, (11), 2009, p2345 - 2349 Journal Article, 2009

Thabit H, Martin G, Brema I, Daly M, Walsh S, Mannion C, Nolan JJ, Immigrant patients with type 2 diabetes mellitus have poorer initial and ongoing glycemic control than a matched population of Irish patients, Irish Medical Journal, 101, 2008, p177 - 180 Journal Article, 2008

Nolan JJ, Free fatty acids in the physiological range are protein-sparing, Acta Physiologica, 192, 2008, p337 - 337 Journal Article, 2008

Szamosi A, Czinner A, Szamosi T, Sallai A, Hatunic M, Berla Z, Tomsits E, Almassy Z, Nolan JJ, Effect of diet and physical exercise treatment on insulin resistance syndrome of schoolchildren, Journal of the American College of Nutrition, 27, 2008, p177 - 183 Journal Article, 2008

Finucane FM, Pittock S, Fallon M, Hatunic M, Ong K, Burns N, Costigan C, Murphy N, Nolan JJ, Elevated blood pressure in overweight and obese Irish children, Irish Medical Journal, 177, 2008, p379 - 381 Journal Article, 2008

Imad Brema1, Mensud Hatunic1, Francis Finucane1, Nicole Burns1, Dominik Haider2, Michael Wolzt2, Bernhard Ludvik3 and John J Nolan1, Plasma Visfatin is Reduced after Aerobic Exercise in Early Onset Type 2 Diabetes Mellitus., Diabetes Obesity and Metabolism, 10, 2008, p600 - 602 Journal Article, 2008

O'Gorman DJ1*, Yousif O1*, Dixon G2, McQuaid S1, Murphy E1,Gasparro D1, Pacini G3, Newsholme P2, Nolan JJ1, In vivo and in vitro studies of GAD-antibody positive subjects with Type 2 diabetes: a distinct sub-phenotype, Diabetes Research and Clinical Practice, 80, 2008, p365 - 370 Journal Article, 2008

Finucane FM, Teong L, Pittock S, Fallon M, Hatunic M, Costigan C, Murphy N, Crowley VEF, Nolan JJ, Adverse Metabolic Profiles in a Cohort of Obese Irish Children, Annals of Clinical Biochemistry, 45, 2008, p206 - 209 Journal Article, 2008

Balkau B, Mhamdi l, Oppert J-M, Nolan JJ, Golay A, Ferrannini E, Physical Activity and Insulin Sensitivity. The RISC Study., Diabetes, 57, 2008, p2613 - 2618 Journal Article, 2008

Hatunic M, Finucane F, Burns N, Gasparro D, Nolan JJ, Vascular inflammatory markers in early onset obese and Type 2 diabetes subjects before and after three months aerobic exercise training., Diabetes and Vascular Disease Research, 2007, p231 - 234 Journal Article, 2007

Finucane F1, Gaffney L2, Hatunic M1, Burns N1, Nolan J.J1, Attendance at an Irish Diabetes Dietetic Outpatient Clinic. , Diabetes Research and Clinical Practice, 77, 2007, p335 - 336 Journal Article, 2007

Ferrannini E, Balkau B, Coppack S, Dekker JM, Mari A, Nolan JJ, Walker M, Natali A, Beck-Nielsen H, Insulin Resistance, insulin exposure, and obesity as indicators of metabolic risk: the RISC Study, Journal of Clinical Endocrinology and Metabolism, 92, 2007, p2885 - 2892 Journal Article, 2007

Burns N, Finucane FM, Hatunic M, Gilman M, Murphy M, Gasparro D, Mari A, Gastaldelli A, Nolan JJ , Early Onset Type 2 Diabetes in Obese Caucasians is Characterised by a Marked Defect in Beta-Cell Insulin Secretion, Severe Insulin Resistance and a Lack of Response to Aerobic Exercise Training, Diabetologia, 50, 2007, p1500 - 1508 Journal Article, 2007

Nolan JJ, What is Type 2 Diabetes?, Medicine, 34, (2), 2006, p52 - 56 Journal Article, 2006

Nolan JJ, O'Halloran D, McKenna TJ, Firth RG, Redmond S., The Cost of Diabetes related Complications in Ireland (CODEIRE-2), Irish Medical Journal, 2006 Journal Article, 2006

Finucane F1, Pittock S2, Fallon M2, Hatunic M1, Burns N1, Costigan C2, Murphy N2, Nolan J.J1. , Clinical Characteristics of Irish Childhood Obesity Referrals since 1990. Int J Obesity, Int Journal of Obesity, 2006 Journal Article, 2006

O'Gorman DJ, Karlsson H, McQuaid S, Yousif O, Rahman Y, Gasparro D, Glund S, Chibalin A, Zierath J, Nolan JJ., Exercise training increases insulin-stimulated glucose disposal and GLUT-4 protein content in patients with Type 2 diabetes., Diabetologia, 49, 2006, p2983 - 2992 Journal Article, 2006

Nolan JJ, O'Halloran D, McKenna TJ, Firth RG, Redmond S., The Cost of Treating Type 2 Diabetes in Ireland (CODEIRE-1), Irish Medical Journal, 100, 2006, p307 - 310 Journal Article, 2006

Manco M, Nolfe G, Calvani M, Natali A, Nolan J, Ferrannini E, Mingrone G, Menopause, insulin resistance and risk factors for cardiovascular disease., Menopause, 13, 2006, p809 - 817 Journal Article, 2006

Wobser H, Bonner C, Nolan JJ, Byrne MM, Prehn JHM, Downregulation of Protein Kinase B/Akt mediates INS-1 Insulinoma cell apoptosis induced by dominant negative suppression of HNF-1a function, Diabetologia, 49, (3), 2006, p519 - 526 Journal Article, 2006

Nolan JJ, Tuomilehto J, Diabetes Care in Ireland: What is Required?, Irish Medical Journal, 2006 Journal Article, 2006

McQuaid S1*, O'Gorman DJ1*,Yousif O1, Yeow TP1, Rahman Y1, Gasparro D1, Pacini G2, Nolan JJ1, Early Onset Insulin-Resistant Diabetes in Obese Caucasians has Features of Typical Type 2 Diabetes, but Three Decades Earlier, Diabetes Care, 28, 2005, p1216 - 1218 Journal Article, 2005

Hatunic M, Burns N, Finucane F, Mannion C, Nolan JJ., Contrasting clinical and cardiovascular risk status between early and later onset Type 2 diabetes., Diabetes Vasc Dis Res , 2, 2005, p73 - 75 Journal Article, 2005

Nolan JJ, Emergency Management of Hypoglycemia: Quantitative Considerations, European Journal of Emergency Medicine , 12, (5), 2005, p213 - 215 Journal Article, 2005

Exercise in Diabetes and Obesity in, editor(s)J Gormley and J Hussey , Exercise in Prevention and Treatment of Disease, UK, Blackwell, 2005, pp59 - 79, [DJ O'Gorman and JJ Nolan] Book Chapter, 2005

Nolan JJ, Emergency Management of Hypoglycemia: Quantitative Considerations., European Journal of Emergency Medicine, 12, (5), 2005, p213 - 215 Journal Article, 2005

Rahman, Y., Knape, T., Gargan, M., Power, G., Hederman, L., Wade, V., Nolan, J., Grimson, J. , e-clinic: an electronic triage system for the management of type 2 Diabetes Mellitus., Medinfo , 11, (11), 2004, p246-250 Journal Article, 2004

D Smith, V Ng, M Bonar, C Merry, C Bergin, MJ Cullen, JJ Nolan , Neurocysticercosis: A rare cause of seizure., Irish Medical Journal, 97, 2004, p264 - 265 Journal Article, 2004

Cullen MG, Nolan JJ, Cullen M, Moloney M, Kearney J, Lambe J and Gibney MJ, The effect of high levels of intense sweetener intake in insulin dependent diabetics on the ratio of dietary sugar to fat: a case control study. , Eur J Clin Nut , 58, 2004, p1336 - 1341 Journal Article, 2004

Baksi A, James RE, Zhou B and Nolan JJ , Comparison of uptitration of gliclazide with the addition of rosiglitazone to gliclazide in patients with Type 2 diabetes inadequately controlled on half maximal doses of a sulphonylurea, Acta Diabetologica, 41, 2004, p63 - 69 Journal Article, 2004

Smith D, Cullen MJ, Nolan JJ, The cost of managing diabetic foot ulceration in an Irish hospital, Ir J Med Sci, 173, 2004, p170 - 173 Journal Article, 2004

Hayes R, Grimson B, Pacini G, Nolan JJ, The evaluation of a windows based computer program implementing the minimal model as used with the intravenous glucose tolerance test in diabetes research and clinical management, Medinfo, 2004, p1636- Journal Article, 2004

Rahman Y, Knape T, Gargan M, Power G, Hederman L, Wade V, Nolan JJ, Grimson J. , e-clinic: An electronic Triage System in the Management of Type 2 Diabetes Mellitus, Medinfo, 2004, p246 - 250 Journal Article, 2004

Fiona Moloney1, Toh PengYeow2, Anne Mullen1, Michael J Gibney1, John J Nolan2 & Helen M. Roche1, Conjugated Linoleic Acid supplementation, insulin sensitivity and lipoprotein metabolism in patients with Type 2 Diabetes Mellitus, Am J Clin Nut , 80, 2004, p887 - 895 Journal Article, 2004

Mogensen CE, Viberti G, Halimi S, Ritz E, Ruilope L, Jermendy G, Widimsky J, Sareli P, Taton J, Rull J, Erdogan G, De Leeuw P, Ribeiro A, Sanchez R, Mechmeche R, Nolan JJ et al, Effect of a very low dose Combination of Perindopril and Indapamide on albuminuria in Type 2 Diabetes - The Premier Study (Preterax in microalbuminuria regression), Hypertension , 41, 2003, p1063 - 1071 Journal Article, 2003

Dixon G, Nolan JJ, Mc Clenaghan N, Flatt PR and Newsholme P, A comparative study of nutrient consumption by rat islet cells and the clonal beta-cell line BRIN BD11 - the functional significance of L-alanine. , J Endocrinology , 179, 2003, p447 - 454 Journal Article, 2003

Ludvik B, Thomaseth K, Nolan JJ, Clodi M, Prager R and Pacini G, Inverse relation between amylin and glucagons secretion in healthy and diabetic human subjects. , Eur J Clin Invest , 33, 2003, p316 - 322 Journal Article, 2003

Conroy S, Green I, Dixon G, Byrne P, Nolan J, Abdel-Wahab HA, McCleneghan N, Flatt PR and Newsholme P. , Evidence for a sustained increase in clonal beta-cell basal intracellular calcium levels after incubation in the presence of newly diagnosed Type 1 diabetic patient sera. Possible role in serum induced inhibition of insulin secretion, J. Endocrinology , 173, 2002, p53 - 62 Journal Article, 2002

Hayes R, Grimson B, Pacini G, Nolan JJ., A strategy to enhance the usability of the minimal model as used with the intravenous glucose tolerance test in diabetes research and clinical management. , Stud Health Technol Inform, 90, 2002, p519 - 524 Journal Article, 2002

What is Type 2 Diabetes? in, editor(s)S Heller and S Dineen , Medicine International , UK, The Medicine Publishing Company, 2002, [Nolan JJ] Book Chapter, 2002

What is the role of the thiazolidinediones (glitazones) in clinical practice? in, editor(s)AH Barnett , Diabetes Annual , UK, Martin Dunitz, 2002, pp119 - 141, [E Murphy and JJ Nolan] Book Chapter, 2002

Tura A, Ludvik B, Nolan JJ, Pacini G and Thomaseth K, Insulin and C-peptide secretion and kinetics in humans: direct and model-based measurements during OGTT., Am J Physiol (Endocrinol Metab) , 281, 2001, pE966 - E974 Journal Article, 2001

Does IGT exist, and if so what should be done about it? in, editor(s)Gill, Pickup and Williams , Difficult Diabetes - Current Management Challenge, UK, Blackwell, 2001, pp22 - 35, [Nolan JJ and Murphy E] Book Chapter, 2001

Mari A, Pacini G, Ludvik B, Murphy E and Nolan JJ, A model-based method for assessing insulin sensitivity from the oral glucose tolerance test , Diabetes Care, 24, 2001, p539 - 548 Journal Article, 2001

Walshe P, Rowley H, McGlone B, Griffin J, Nolan J and Timon C, Clinical Problem Solving: Radiology Quiz Case 1 (Lingual Thyroid). , Arch Otolaryngol Head Neck Surg , 127, 2001, p1506- Journal Article, 2001

Insulin sensitzer Drugs in, Expert Opinion on Investigational Drugs, 2000, pp1347 - 1361, [E Murphy and JJ Nolan] Book Chapter, 2000

Conroy S, Yasser HA, Abdel-Wahab, Caraher EM, Byrne PM, Murphy E, Nolan JJ, Flatt P and Newsholme P, Evidence for complement-dependent and independent inhibition of insulin secretion from clonal beta-cells incubated in the presence of newly diagnosed IDDM patient sera, J Endocrinology, 164, 2000, p139 - 147 Journal Article, 2000

Nolan JJ, Jones NP, Patwardhan R and Deacon L , Rosiglitazone taken once daily provides effective glycemic control in patients with Type 2 diabetes mellitus, Diabetic Medicine, 17, 2000, p287 - 294 Journal Article, 2000

Insulin Sensitizers in, editor(s)D. John Betteridge , Diabetes: Current Perspectives, UK, Martin Dunitz, 1999, pp267 - 293, [Nolan, J.J] Book Chapter, 1999

O'Toole EA, Kennedy U, Nolan JJ, Young MM and Barnes L, Necrobiosis Lipoidica: only a minority of patients has diabetes mellitus, Brit. J. Dermatol , 140, 1999, p283 - 286 Journal Article, 1999

Insulin Sensitizers in, editor(s)K. Hatt , Topical Endocrinology, UK, Chapterhouse Codex, 1999, pp11 - 14, [Nolan, J.J] Book Chapter, 1999

Maggs DG, Burant CF, Buchanan TA, Cline G, Gumbiner B, Hsueh WA, Inzucchi S, Kelley D, Nolan JJ, Olefsky JM, Polonsky KS, Siilver D, Valiquett TR, Shulman GI. , Metabolic Effects of Troglitazone Monotherapy in Type II Diabetes Mellitus: A Randomized, Double-blind, Placebo controlled Trial. , Ann Int Med, 128, 1998, p176 - 185 Journal Article, 1998

Obesity in, editor(s)C. Wayne Bardin , Current Therapy of Endocrinology and Metabolism, 6th edition, USA, Mosby, 1997, pp505 - 509, [Nolan, J.J. and Henry, R.R] Book Chapter, 1997

Insulin Action and Insulin Resistance in NIDDM in, editor(s)Draznin, B and Rizza, R , Clinical Research in Diabetes and Obesity: Volume II: Diabetes and Obesity, USA, The Humana Press, 1997, pp137 - 158, [Nolan, J.J. and Olefsky, J.M. ] Book Chapter, 1997

Deftos, LJ, Nolan JJ, Seely BL, Clopton PL, Cote GJ, Whitham CL, Florek LJ, Christensen, Hill MR, Intrapulmonary drug delivery of salmon calcitonin, Calcified Tissue Int, 61, 1997, p345 - 347 Journal Article, 1997

Thomaseth, K, Pacini G, Clodi M, Kautzky-Willer A, Nolan JJ, Prager R, Olefsky JM, Ludvik B., Amylin Release During Oral Glucose Tolerance Test, Diabetic Medicine, 14, 1997, pS29 - S34 Journal Article, 1997

Syndromes Involving Multiple Endocrine Glands. in, editor(s)Greenspan, F. and Strewler, G , Basic and Clinical Endocrinology, USA, Appleton and Lange, 1997, pp753 - 770, [Deftos, L.J., Catherwood, B. and Nolan, J.J] Book Chapter, 1997

Nolan, J.J., Ludvik, B., Joyce, M., Reichart, D., Bell, J and Olefsky, J.M. , Mechanisms of the Kinetic Defect in Insulin Action in Obesity and NIDDM , Diabetes, 46, 1997, p994 - 1000 Journal Article, 1997

Ludvik, B., Nolan JJ, Roberts, A, Baloga, J, Joyce, M, Bell, JM and Olefsky, JM, Evidence for Decreased Splanchnic Glucose Uptake After Oral Glucose Administration in Non-Insulin Dependent Diabetes Mellitus, J. Clin. Invest , 100, 1997, p2354 - 2361 Journal Article, 1997

Nolan, J.J., Olefsky, J.M., Nyce, M.R., Considine, R.V. and Caro, J.F, Effect of Troglitazone on Leptin Production: Studies in Vitro and in Human Subjects, Diabetes, 45, 1996, p1276 - 1278 Journal Article, 1996

Kolaczynski, J.W., Nyce, M.R., Considine, R.V., Boden, G., Nolan, J.J., Henry, R., Mudaliar, S.R., Olefsky, J. and Caro, J.F. , Acute and Chronic Effect of Insulin on Leptin Production in Humans: Studies in vivo and in vitro, Diabetes, 45, 1996, p699 - 701 Journal Article, 1996

Insulin Resistance and Non-Insulin Dependent Diabetes Mellitus: Cellular and Molecular Mechanisms in, Am J Clin Nut, USA, 1995, pp980S - 986S, [Olefsky, J.M. and Nolan, J.J. ] Book Chapter, 1995

Ludvik, B., Nolan, J.J., Roberts, A., Baloga, J., Joyce, M., Bell, J and Olefsky, J.M., A Noninvasive Method to Measure Splanchnic Glucose Uptake after Oral Glucose Administration, J. Clin. Invest, 95, 1995, p2232 - 2238 Journal Article, 1995

Ludvik, B., Nolan, J.J., Baloga, J., Sacks, D. and Olefsky, J.M, Effect of obesity on Insulin Resistance in normal subjects and patients with NIDDM., Diabetes, 44, 1995, p1121 - 1125 Journal Article, 1995

Multiple Etiologies for Insulin Resistance in NIDDM in, editor(s)R. Kawamori, M. Vranic, E.S. Horton, M. Kubota , Glucose Fluxes, exercise and diabetes, USA, Smith-Gordon & Co, 1995, pp193 - 200, [Nolan, J.J. and Olefsky, J.M] Book Chapter, 1995

Nolan,J.J., Ludvik, B., Beerdsen, P., Joyce, M. and Olefsky, J.M, Improvement in Glucose Tolerance and Insulin Resistance in Obese Subjects Treated with Troglitazone, N. Engl. J. Med, 331, 1994, p1188 - 1193 Journal Article, 1994

Nolan, J.J., Freidenberg, G.R., Henry, R.R., Reichart, D. and Olefsky, J.M, Role of Human Skeletal Muscle Insulin Receptor Kinase in the Insulin Resistance of NIDDM and Obesity., J. Clin. Endocrinol. Metab , 78, 1994, p471 - 477 Journal Article, 1994

Morales, A.J., Nolan, J.J., Nelson, J.C. and Yen, S.S.C, Effects of Replacement Dose of Dehydoepiandrosterone (DHEA) in Men and Women of Advancing Age, J. Clin. Endocrinol. Metab, 78, 1994, p1360 - 1367 Journal Article, 1994

Freidenberg, G.R., Suter, S., Henry, R.R., Nolan, J.J., Reichart, D., and Olefsky, J.M. , Delayed onset of Insulin Activation of the Insulin Receptor Kinase in vivo in human skeletal muscle, Diabetes, 43, 1994, p118 - 126 Journal Article, 1994

Suter, S., Nolan, J. et al, Metabolic effects of a new Oral Hypoglycemic Agent, CS-045, in noninsulin dependent diabetic subjects, Diabetes Care, 15, 1992, p193 - 203 Journal Article, 1992

Non-Peer-Reviewed Publications

JJ Nolan, Current Perspectives in Paediatric Type 2 Diabetes, International Society for Paediatric and Adolescent Diabetes, Singapore, November 2004, edited by Merck Sante , 2004, pp1 - 8 Conference Paper, 2004

Research Expertise


Clinical research, trials; Computerised clinical systems; Diabetes and diabetic complications; Exercise physiology; Genetic/Molecular epidemiology; Genomic structure and function, molecular approaches to gene function; Intra and intercellular signalling; Metabolism and metabolic diseases; Nutrient metabolism, obesity and clinical nutrition; Nutrition; Obesity


Awards and Honours

State of the Art Lecture, EASD meeting, Stockholm 1995

State of the Art Lecture, Swedish Diabetes Association 1996

Keynote Speaker, Karolinska Institute Symposium on Type 2 Diabetes 2000

Nordisk Lecture of the Irish Endocrine Society 2003


Irish Endocrine Society 1996 – present

European Society for Clinical Investigation 1999 – present

The Endocrine Society 1991 – present

European Association for Study of Diabetes 1991 – present

American Diabetes Association 1991 – present