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Dr. Emer Guinan
Assistant Professor, School Office - Medicine

Publications and Further Research Outputs

Peer-Reviewed Publications

O'Neill L., Reynolds S., Sheill G., Guinan E., Mockler D., Geoghegan J., Conlon K., Reynolds, J.V., Hussey J., Physical function in patients with resectable cancer of the pancreas and liver-a systematic review, Journal of Cancer Survivorship, 2020 Journal Article, 2020 DOI

O'NEILL L., GUINAN E., DOYLE S., CONNOLLY D., O'SULLIVAN J., BENNETT A., SHEILL G., SEGURADO R., KNAPP P., FAIRMAN C., NORMAND C., GEOGHEGAN J., CONLON K., REYNOLDS JV., HUSSEY J., 'Rehabilitation strategies following oesophagogastric and hepatopancreaticobiliary cancer (ReStOre II): a protocol for a randomised controlled trial', 2020, - Protocol or guideline, 2020 DOI

Sheill G., Guinan E., O'Neill L., Normand C., Doyle SL., Moore S., Newell J., McDermott G., Ryan R., Reynolds JV., Hussey J., Preoperative exercise to improve fitness in patients undergoing complex surgery for cancer of the lung or oesophagus (PREHIIT): protocol for a randomized controlled trial, BMC Cancer, 2020 Journal Article, 2020 DOI

Sheill G., Reynolds S., O'Neill L., Mockler D., Reynolds JV., Hussey J., Guinan E.,, Cardiopulmonary Exercise Testing in Oesophagogastric Surgery: a Systematic Review, Cardiopulmonary Exercise Testing in Oesophagogastric Surgery: a Systematic Review, 2020, p12 Journal Article, 2020 DOI

Guinan, E.M., Bennett, A.E., Doyle, S.L., O'Neill, L, Gannon, J., Foley, G., Elliott, J.A., O'Sullivan, J., Reynolds, J.V., & Hussey, J., Measuring the impact of oesophagectomy on physical functioning and physical activity participation: a prospective study, BMC Cancer, 19, (682), 2019 Journal Article, 2019 TARA - Full Text DOI URL

Elliott J.A., O'Byrne L., Foley G., Murphy C.F., Doyle S.L., Kind S., Guinan E.M., Narayanasamy R., Reynolds J.B, The effect of neoadjuvant chemoradiation on preoperative pulmonary physiology, postoperative respiratory complications and quality of life in patients with oesophageal cancer , British Journal of Surgery, 106, (10), 2019, p1341 - 1351 Journal Article, 2019 URL

Devenney KE, Guinan EM, Kelly ÁM, Mota BC, Walsh C, Rikkert MO, Scneider S, Lalor B., Acute high-intensity aerobic exercise affects brain-derived neurotrophic factor in mild cognitive impairment: a randomised controlled study, BMJ Open Sport & Exercise Medicine, 5, 2019 Journal Article, 2019 DOI

Sheill G, Guinan E, Brady L, Hevey D, Hussey J., Exercise interventions for patients with advanced cancer: A systematic review of recruitment, attrition, and exercise adherence rates., Palliative and Supportive Care, 17, (6), 2019, p686 - 696 Journal Article, 2019 DOI

Haberlin C, Broderick J., Guinan E.M, Darker C., Hussey J., O'Donnell D.M., E-Health based intervention to increase physical activity levels in people with cancer: protocol of a feasibility trial in an Irish acute hospital setting, BMJ Open, 9: e024999, 2019 Journal Article, 2019 URL

O'Neill, L.M., Bennett, A.E., Guinan, E., Reynolds, J.V., Hussey, J., Physical recovery in the first six months following oesophago-gastric cancer surgery. Identifying rehabilitative needs: a qualitative interview study, Disability and Rehabilitation, 2019, p1-8 Journal Article, 2019 URL DOI

O'Neill L., Knapp P., Doyle SL., Guinan E., Parker A.,Segurado R., Connolly D., O'Sullivan J., Reynolds JV., Hussey J, 'Patient and family co-developed participant information to improve recruitment rates, retention, and patient understanding in the Rehabilitation Strategies Following Oesophago-gastric and Hepatopancreaticobiliary Cancer (ReStOre II) trial: Protocol for a study within a trial (SWAT) [version 1; peer review: awaiting peer review]', 2019, - Protocol or guideline, 2019 DOI

Elliott J.A., Docherty N., Murphy C., Eckhardt H., Doyle S.L., Guinan E., Ravi N., Reynolds J.V., Le Roux C, Changes in gut hormones, glycaemic response and symptoms after oesophagectomy, British Journal of Surgery, 106, (6), 2019, p735 - 746 Journal Article, 2019 DOI

Valkenet K., Trappenburg T., Ruurda J., Guinan E., Reynolds J.V., Nafteux P., Fontaine M., Rodrigo E., van det Peet D., Hania S., Sosef M., Willms J., Rosman C., Pieters H., Scheepers J., Faber T., Kouwenhoven E., Tinselboer M., Rasanen J., Ryynanen H., Fosselink R., van Hillegersberg R., Backx F. , 'Preoperative inspiratory muscle training in patients undergoing esophagectomy: the results of the PREPARE trial, an international multicenter RCT, British Journal of Surgery, 105, (5), 2018, p502 - 511 Journal Article, 2018 URL

O'Neill, L. and Moran, J. and Guinan, E.M. and Reynolds, J.V. and Hussey, J., Physical decline and its implications in the management of oesophageal and gastric cancer: a systematic review, Journal of Cancer Survivorship, 12, (4), 2018, p601 - 618 Journal Article, 2018 DOI

O'Neill, L.M., Guinan, E., Doyle, S.L., Bennett, A.E., Murphy, C., Elliott, J.A., O'Sullivan, J., Reynolds, J.V., Hussey, J., The RESTORE Randomized Controlled Trial: Impact of a multidisciplinary rehabilitative program on cardiorespiratory fitness in esophagogastric cancer survivorship, Annals of Surgery, 268, (5), 2018, p747 - 755 Journal Article, 2018 URL DOI

Bennett, A.E., O'Neill, L., Connolly, D., Guinan, E.M., Boland, L., Doyle, S.L., O'Sullivan, J., Reynolds, J.V., & Hussey, J., Patient experiences of a physiotherapy-led multidisciplinary rehabilitative intervention after successful treatment for oesophago-gastric cancer, Supportive Care in Cancer, 26, (8), 2018, p2615 - 2623 Journal Article, 2018 URL DOI

Sheill G., Guinan E.M., Peat N., Hussey J , Considerations for Exercise Prescription in Patients with Bone Metastases: A Comprehensive Narrative Review. , Physical Medicine and Rehabilitation , 10, (8), 2018, p843 - 864 Review Article, 2018 DOI

Sheill. G., Guinan, E.M., O'Neill L, Hevey, D., Hussey, J. , Physical Activity and Advanced Cancer: The views of Chartered Physiotherapists in Ireland. , Physiotherapy Theory and Practice, 3, 2018, p1 - 8 Journal Article, 2018 DOI

Sheill G, Guinan E, O Neill L., Hevey D., Hussey J. , Physical Activity and Advanced Cancer: The views of Oncology and Palliative Care Physicians in Ireland. , Irish Journal of Medical Science, 187, (2), 2018, p337 - 343 Journal Article, 2018 DOI

Mulcahy S, Prendergast J, Foley G, O'Hare A, Murphy E, Guinan EM, Hussey J, Exercise Rehabilitation services provided by physiotherapy departments in Ireland., Irish Medical Journal , 111, (9), 2018, p818- Journal Article, 2018 Other

Stuckenschneider T, Askew C.D., Rudiger S., Cristina Polidori M., Abeln V, Vogt T, Krome A, Olde Rikkert M, Lawlor B., Schneider S., NeuroExercise Study Group , Cardiorespirataory fitness and cognitive function are positively related among participants with mild and subjective cognitive impairment, Journal of Alzheimer's Disease,, 62, (4), 2018, p1865 - 1875 Journal Article, 2018 URL

Hussey JM, Yang T, Dowds J, O'Connor L, Reynolds JV, Guinan EM., Quantifying postoperative mobilisation following oesophagectomy., Physiotherapy, 105, (1), 2018, p126 - 133 Journal Article, 2018 DOI

Guinan, E.M., Doyle, S.L., Bennett, A.E., O'Neill, L, Gannon, J., Elliott, J.A., O'Sullivan, J., Reynolds, J.V., & Hussey, J., Sarcopenia during neoadjuvant therapy for oesophageal cancer: characterising the impact on muscle strength and physical performance, Supportive Care in Cancer, 26, (5), 2018, p1569 - 1576 Journal Article, 2018 DOI URL

Newton RU, Kenfield SA, Hart NH, Chan JM, Courneya KS, Catto J, Finn SP, Greenwood R, Hughes DC, Mucci L, Plymate SR, Praet SFE, Guinan EM, Van Blarigan EL, Casey O, Buzza M, Gledhill S, Zhang L, Galvão DA, Ryan CJ, Saad F., Intense Exercise for Survival among Men with Metastatic Castrate-Resistant Prostate Cancer (INTERVAL-GAP4): a multicentre, randomised, controlled phase III study protocol., BMJ Open, 8, (5), 2018 Journal Article, 2018 DOI

Guinan EM, Forde C, O'Neill L, Gannon J, Doyle SL, Valkenet K, Trappenburg JCA, van Hillegersberg R, Ravi N, Hussey JM, Reynolds JV., Effect of preoperative inspiratory muscle training on physical functioning following esophagectomy., Diseases of the Esphagus, 32, (32), 2018, pdoy091- Journal Article, 2018 DOI

Sanders M.L., Stuckenschneider T, Devenney K.E. Lawlor B., Schneider S, Olde Rikkert M.G.M., NeuroExercise Study Group , ) Real world recruiting of older subjects with mild cognitive impairment for exercise trials: community readiness is pivotal, Journal of Alzheimer's Disease, 62, (2), 2018, p579 - 581 Journal Article, 2018 URL

Gannon, J.A., Guinan E.M., Doyle S.L., Beddy P., Reynolds J.V., Hussey J. , Reduced Fitness and Physical Functioning are long-term Sequelae after Curative Treatment for Oesophageal Cancer: a Case-Control Study. , Diseases of the Esophagus, 30, (8), 2017, p1 - 7 Journal Article, 2017 DOI

O'Neill L, Gannon J, Guinan E, Reynolds JV, Hussey J. , Multidisciplinary rehabilitation across the esophageal cancer journey, Journal of Thoracic Diseases, 9, (12), 2017, pE1140 - E1142 Journal Article, 2017 TARA - Full Text DOI

Sheill G, Guinan E, Neill LO, Hevey D, Hussey J, The views of patients with metastatic prostate cancer towards physical activity: a qualitative exploration, Supportive Care in Cancer, 26, (6), 2017, p1747 - 1754 Journal Article, 2017 DOI

Sheill G; Brady L; Guinan E; Hayes B; Casey O; Greene J; Vlajnic T; Cahill F; Van Hemelrijck M; Peat N; Rudman S; Hussey J; Cunningham M; Grogan L; Lynch T; Manecksha R; McCaffrey J; Mucci L; Sheils O; O Leary J; M O Donnell D; McDermott R; Finn S. , The ExPeCT (Exercise, Prostate Cancer and Circulating Tumour Cells) Trial: Study protocol for a randomised controlled trial. , Trials, 18, 2017, p456- Journal Article, 2017 DOI

Moran, J., Guinan, E., McCormick, P., Larkin, J., Mockler, D., Hussey, J., Moriarty, J., Wilson, F. , Response to: Is prehabilitation limited to preoperative exercise? , Surgery, 162, (1), 2017, p192 - 193 Journal Article, 2017 DOI

Devenney KE, Sanders ML, Lawlor B, Olde Rikkert MGM, Schneider S; NeuroExercise Study Group, The effects of an extensive exercise programme on the progression of Mild Cognitive Impairment (MCI): study protocol for a randomised controlled trial., BMC Geriatrics, 17, (1), 2017, p75- Journal Article, 2017 URL DOI

Guinan, E.M., Dowds, J., Donohoe, C., Reynolds, J.V., Hussey, J., The physiotherapist and the esophageal cancer patient: From prehabilitation to rehabilitation, Diseases of the Esophagus, 30, (1), 2017, p1-12 Journal Article, 2017 DOI

Rudiger S., Stuckenschneider T, Vogt T, Abeln V., Lawlor B., Olde Rikkert M., Schneider S., NeuroExercise Study Group, Cognitive impairment is reflected by an increased difference between and imagined timed up and go performance, Dementia and Geriatric Cognitive Disorders, 44, (1-2), 2017, p55 - 62 Journal Article, 2017 DOI

Elliott J.A., Doyle, S.L., Murphy C.F., King S., Guinan E.M., Beddy, P., Narayanasamy, R. (, Sarcopenia: Prevalence, and Impact on Operative and Oncologic Outcomes in the Multimodal Management of Locally Advanced Esophageal Cancer , Annals of Surgery, 266, (5), 2017, p822 - 830 Journal Article, 2017 DOI

Linda O'Neill, Emer Guinan, Suzanne L Doyle, Jessie A. Elliott, Jacintha O'Sullivan, John V. Reynolds, Juliette Hussey, Rehabilitation Strategies following esophageal cancer (the ReStOre trail): a feasibility study, Diseases of the Esophagus, 30, (5), 2017, p1 - 8 Journal Article, 2017 DOI

Moran J., Guinan E., McCormick P., Larkin J., Mockler D., Hussey J., Moriarty J., Wilson F., The ability of prehabilitation to influence postoperative outcome after intra-abdominal operation: A systematic review and meta-analysis, Surgery (United States), 160, (5), 2016, p1189-1201 Journal Article, 2016 DOI

Moran, J., Wilson, F., Guinan, E., McCormick, P., Hussey, J., Moriarty, J., Role of cardiopulmonary exercise testing as a risk-assessment method in patients undergoing intra-abdominal surgery: A systematic review, British Journal of Anaesthesia, 116, (2), 2016, p177-191 Journal Article, 2016 TARA - Full Text DOI

Guinan, E.M., Doyle, S.L., O'Neill, L., Dunne, M.R., Foley, E.K., O'Sullivan, J., Reynolds, J.V., Hussey, J., Effects of a multimodal rehabilitation programme on inflammation and oxidative stress in oesophageal cancer survivors: the ReStOre feasibility study, Supportive Care in Cancer, 25, (3), 2016, p749 - 756 Journal Article, 2016 DOI

Moran, J., Wilson, F., Guinan, E., McCormick, P., Hussey, J., Moriarty, J., The preoperative use of field tests of exercise tolerance to predict postoperative outcome in intra-abdominal surgery: a systematic review, Journal of Clinical Anesthesia, 35, 2016, p446-455 Journal Article, 2016 DOI

Elliott, J.A., Docherty, N.G., Eckhardt, H.-G., Doyle, S.L., Guinan, E.M., Ravi, N., Reynolds, J.V., Roux, C.W.L., Weight Loss, Satiety, and the Postprandial Gut Hormone Response After Esophagectomy: A Prospective Study, Annals of Surgery, 266, (1), 2016, p82 - 90 Journal Article, 2016 DOI TARA - Full Text

Moran J, Murphy A, Murphy D, Austin A, Moran D, Cronin C, Guinan E, Hussey J, The energy expenditure of non-weight bearing crutch walking on the level and ascending stairs., Gait & posture, 42, (1), 2015, p23-6 Journal Article, 2015 DOI

Cahir, C., Guinan, E., Dombrowski, S.U., Sharp, L., Bennett, K., Identifying the determinants of adjuvant hormonal therapy medication taking behaviour in women with stages I-III breast cancer: A systematic review and meta-analysis, Patient Education and Counseling, 98, (12), 2015, p1524-1539 Journal Article, 2015 TARA - Full Text

Broderick, J. M. Guinan, E. Donnell, D. M. O' Hussey, J. Tyrell, E. Normand, C., Calculating the costs of an 8-week, physiotherapy-led exercise intervention in deconditioned cancer survivors in the early survivorship period (the PEACH trial), Physiotherapy, 100, (2), 2014, p182 - 184 Journal Article, 2014 TARA - Full Text

Valkenet K, Trappenburg JC, Gosselink R, Sosef MN, Willms J, Rosman C, Pieters H, Scheepers JJ, de Heus SC, Reynolds JV, Guinan E, Ruurda JP, Rodrigo EH, Nafteux P, Fontaine M, Kouwenhoven EA, Kerkemeyer M, van der Peet DL, Hania SW, van Hillegersberg R, Backx FJ, Preoperative inspiratory muscle training to prevent postoperative pulmonary complications in patients undergoing esophageal resection (PREPARE study): study protocol for a randomized controlled trial., Trials, 15, (1), 2014, p144 Journal Article, 2014 DOI TARA - Full Text

Guinan, E.M., Connolly, E.M., Hussey J , Physical Activity and Obesity Related Biomarkers in Breast Cancer Survivors, Physical Therapy Reviews, 18, (3), 2013, p229 - 231 Review Article, 2013 DOI

Guinan E., Hussey J., McGarrigle S.A., Healy L.A., O'Sullivan J.N., Bennett K., Connolly E.M., A Prospective Investigation of Predictive and Modifiable Risk Factors for Breast Cancer in Unaffected BRCA1 and BRCA2 Gene Carriers., BMC Cancer, 13, (138), 2013 Journal Article, 2013 DOI

Broderick JM, Guinan E, Kennedy MJ, Hollywood D, Courneya KS, Culos-Reed SN, Bennett K, O'Donnell DM, Hussey J, Feasibility and efficacy of a supervised exercise intervention in de-conditioned cancer survivors during the early survivorship phase, Journal of Cancer Survivorship, 7, (4), 2013, p551 - 562 Journal Article, 2013 DOI

Guinan EM, Connolly EM, Healy LA, Carroll PA, Kennedy MJ, Hussey J , The Development of the Metabolic Syndrome and Insulin Resistance After Adjuvant Treatment for Breast Cancer, Cancer Nursing, Epub ahead of print, 2013 Journal Article, 2013 DOI

Guinan E, Hussey J, Broderick JM, Lithander FE, O'Donnell D, Kennedy MJ, Connolly EM, The effect of aerobic exercise on metabolic and inflammatory markers in breast cancer survivors-a pilot study., Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 21, (7), 2013, p1983-1992 Journal Article, 2013 TARA - Full Text URL DOI

Guinan, E.M., Connolly, E.M., Hussey J , Exercise training in breast cancer survivors: a review of trials examining anthropometric and obesity-related biomarkers of breast cancer risk, Physical Therapy Reviews , 18, (2), 2013, p79 - 89 Review Article, 2013 DOI

Guinan EM, Connolly EM, Kennedy MJ, Hussey J., The presentation of metabolic dysfunction and the relationship with energy output in breast cancer survivors: a cross-sectional study, Nutr J. , 12, (1), 2013 Journal Article, 2013 DOI

Walsh JM, Hussey J, Guinan E, O' Donnell D, 'Pragmatic randomized controlled trial of individually prescribed exercise versus usual care in a heterogeneous cancer survivor population': a feasibility study PEACH trial: prescribed exercise after chemotherapy., BMC Cancer, 10, (42), 2010 Journal Article, 2010 TARA - Full Text DOI URL

Non-Peer-Reviewed Publications

Promoting Leadership Skills Through Interprofessional Education in, editor(s)Morison S , Leadership: Perception, Influences and Gender Differences, NOVA science publishers, 2017, pp103 - 139, [Guinan E.M. and McGowen E.] Book Chapter, 2017

Research Expertise

Description

I am an Assistant Professor in the School of Medicine with responsibility for the Interprofessional Learning programme for the Faculty of Health Sciences. My main research interest is in the role of exercise and physical activity in ameliorating treatment side effects and optimising survivorship for patients with cancer. My work considers both the therapeutic and the physiological impact of exercise programmes. I have a particular interest in the role of exercise for patients with complex cancer presentations including patients with cancer of the gastrointestinal tract and those with advanced disease. I have been awarded >€1.6 million in research funding as either principle investigator or co-applicant from external peer-reviewed grants (Health Research Board, Irish Cancer Society, Medical Charities Research Group), external research bursaries (Irish Society of Chartered Physiotherapists) and internal competitions from the Faculty of Health Sciences, Trinity College. I have published over 50 peer reviewed publications and 1 book chapter. In addition, I lead an interprofessional learning research programme across the Faculty of Health Sciences.

Projects

  • Title
    • Preoperative inspiratory muscle training to prevent postoperative pulmonary complications in patients undergoing esophageal resection (the PREPARE study)
  • Summary
    • This multi-centre international trial is examining the effect of a preoperative programme of inspiratory muscle training on post-operative pulmonary outcomes in patients undergoing oesophagectomy
  • Title
    • Rehabilitative Strategies Following Oesophageal Cancer (ReStOre trial)
  • Summary
    • This project comprises two studies; 1)a longitudinal assessment of the effect of curative treatment for oesopahgeal cancer on physical performance and 2) an investigation of the feasibility and efficacy of a rehabilitative programme of exercise and dietary intervention following oesophageal cancer treatment completion.
  • Funding Agency
    • Health Research Board (HRB)
  • Date From
    • Oct 2014
  • Title
    • Knowledge Exchange and Dissemination: Community Exercise
  • Summary
    • This research programme aims to enable patients who are participating in exercise training programmes at the Wellcome Trust-HRB Clinical Research Facility at St James's Hospital to exercise locally by addressing patient-reported barriers to community exercise participation
  • Funding Agency
    • Health Research Board
  • Date From
    • 01.01.2018
  • Date To
    • 31.12.2018
  • Title
    • Rehabilitation Strategies following Oesophagogastric and Hepatopancreaticobiliary Cancer
  • Funding Agency
    • Health Research Board
  • Date From
    • 01.05.2019
  • Date To
    • 01.05.2023
  • Title
    • Preoperative Exercise to Improve Fitness in Patients Undergoing Complex Surgery for Cancer of the Lung or Oesophagus
  • Funding Agency
    • MRCG-HRB
  • Date From
    • 07.12.2018
  • Date To
    • 06.02.2022
  • Title
    • Exercise prescription in patients with bone metastases: identifying clinical tools to overcome clinician concerns regarding skeletal related events.
  • Funding Agency
    • Irish Cancer Society and the All Ireland Institute of Hospice and Palliative Care Research Award.
  • Date From
    • 01.02.2019
  • Date To
    • 01.02.2021

Keywords

Cancer Survivorship; Exercise Medicine; inter-professional collaboration; inter-professional practice; Inter/Multidisciplinary Education; Interprofessional Education in Healthcare; LUNG CANCER; multi-disciplinary; Oesophageal cancer; POSTOPERATIVE COMPLICATIONS; Prostate cancer; Rehabilitation/Therapy, Physical; UPPER GASTROINTESTINAL CANCER

Recognition

Memberships

Irish Society of Chartered Physiotherapists (ISCP) July 2009 – present

CORU Physiotherapy Registration Board 2019 – Present