Dr. Emer Guinan
Assistant Professor, Surgery
Assistant Professor, School Office - Medicine
Publications and Further Research Outputs
Peer-Reviewed Publications
REYNOLDS SA., O'CONNOR L., McGEE A., QUINN KILCOYNE A., CONNOLLY A., MOCKLER D., GUINAN E., O'NEILL L, Recruitment rates and strategies in exercise trials in cancer survivorship: a systematic review, Journal of Cancer Survivorship, 2023
Brennan, L., Sadeghi, F., O'Neill, L., Guinan, E., Smyth, L. Sheill, G., Smyth, E., Doyle, S.L., Timon, C., Connolly, D., O'Sullivan, J., Reynolds, J.V., and Hussey, J., Telehealth Delivery of a Multi-Disciplinary Rehabilitation Programme for Upper Gastro-Intestinal Cancer: ReStOre@Home Feasibility Study, Cancers, 2022
Grimes T, Guinan E, Interprofessional Education focused on Medication Safety: A Systematic Review., Journal of Interprofessional Care, 2022, p1 - 20
Brennan, L. Sheill, G. O'Neill, L, O'Connor, L, Smyth, E. Guinan, E, Physical Therapists in Oncology Settings: Experiences in Delivering Cancer Rehabilitation Services, Barriers to Care, and Service Development Needs, Physical Therapy, 2022
Bennett, A.E., O'Neill, L., Connolly, D., Guinan, E., Boland, L., Doyle, S., O'Sullivan, J., Reynolds, J.V., Hussey, J., Perspectives of Esophageal Cancer Survivors on Diagnosis, Treatment, and Recovery., Cancers, 13, (1), 2021, p1-12
Kennedy, S.A., Annett, S.L., Dunne, M.R., Boland, F., O'Neill, L.M., Guinan, E.M., Doyle, S.L., Foley, E.K., Elliott, J.A., Murphy, C.F., Bennett, A.E., Carey, M., Hillary, D., Robson, T., Reynolds, J.V., Hussey, J., O'Sullivan, J.N., Effect of the Rehabilitation Program, ReStOre, on Serum Biomarkers in a Randomized Control Trial of Esophagogastric Cancer Survivors, Frontiers in Oncology, 11, (669078), 2021, p1-11
ALKHAFFAF B., BLAZEBY JM, ET AL AND ON BEHALF OF THE GASTROS INTERNATIONAL WORKING GROUP, Methods for conducting international Delphi surveys to optimise global participation in core outcome set development: a case study in gastric cancer informed by a comprehensive literature review, Trials, 2021, phttps://doi.org/10.1186/s13063
Sheill G., Hennessy M., O'Neill L., Reynolds S., Towns J., Gill M., Guinan E., Exercise and chronic health conditions in the community: A qualitative Study of Patients and Fitness instructors, Health and Social Care in the Community, 2021
Sheill G., Guinan E., O'Neill L., Normand C., Doyle SL., Moore S., Newell J., McDermott G., Ryan R., Reynolds JV., Hussey J., Preoperative exercise to improve fitness in patients undergoing complex surgery for cancer of the lung or oesophagus (PREHIIT): protocol for a randomized controlled trial, BMC Cancer, 2020
O'NEILL L., GUINAN E., DOYLE S., CONNOLLY D., O'SULLIVAN J., BENNETT A., SHEILL G., SEGURADO R., KNAPP P., FAIRMAN C., NORMAND C., GEOGHEGAN J., CONLON K., REYNOLDS JV., HUSSEY J., Rehabilitation strategies following oesophagogastric and hepatopancreaticobiliary cancer (ReStOre II): a protocol for a randomised controlled trial, BMC Cancer, 20, 2020, p1 - 20
Sheill G., Reynolds S., O'Neill L., Mockler D., Reynolds JV., Hussey J., Guinan E.,, Cardiopulmonary Exercise Testing in Oesophagogastric Surgery: a Systematic Review, Cardiopulmonary Exercise Testing in Oesophagogastric Surgery: a Systematic Review, 2020, p12
Sheill G., Reynolds S., O'Neill L., Mockler D., Reynolds J.V., Hussey J., Guinan E, Cardiopulmonary Exercise Testing in Oesophagogastric Surgery: a Systematic Review, Journal of Gastrointestinal Surgery. , 24, 2020, p2667 - 2678
O'Neill L., Reynolds S., Sheill G., Guinan E., Mockler D., Geoghegan J., Conlon K., Reynolds, J.V., Hussey J., Physical function in patients with resectable cancer of the pancreas and liver-a systematic review, Journal of Cancer Survivorship, 2020
O'Neill L., Guinan E., Doyle S., O'Connor L., Sheill G., Smyth E., Fairman C., Segurado R., Connolly D., O'Sullivan J., Reynolds JV., Hussey J, ReStOre@Home: Feasibility study of a virtually delivered 12-week multidisciplinary rehabilitation programme for survivors of upper gastrointestinal (UGI) cancer - study protocol, HRB Open Research, 2020
Sheill G, Guinan E, Brady L, Hevey D, Hussey J., Exercise interventions for patients with advanced cancer: A systematic review of recruitment, attrition, and exercise adherence rates., Palliative and Supportive Care, 17, (6), 2019, p686 - 696
Elliott J.A., Docherty N., Murphy C., Eckhardt H., Doyle S.L., Guinan E., Ravi N., Reynolds J.V., Le Roux C, Changes in gut hormones, glycaemic response and symptoms after oesophagectomy, British Journal of Surgery, 106, (6), 2019, p735 - 746
Devenney KE, Guinan EM, Kelly ÁM, Mota BC, Walsh C, Rikkert MO, Scneider S, Lalor B., Acute high-intensity aerobic exercise affects brain-derived neurotrophic factor in mild cognitive impairment: a randomised controlled study, BMJ Open Sport & Exercise Medicine, 5, 2019
Elliott J.A., O'Byrne L., Foley G., Murphy C.F., Doyle S.L., Kind S., Guinan E.M., Narayanasamy R., Reynolds J.B, The effect of neoadjuvant chemoradiation on preoperative pulmonary physiology, postoperative respiratory complications and quality of life in patients with oesophageal cancer , British Journal of Surgery, 106, (10), 2019, p1341 - 1351
O'Neill, L.M., Bennett, A.E., Guinan, E., Reynolds, J.V., Hussey, J., Physical recovery in the first six months following oesophago-gastric cancer surgery. Identifying rehabilitative needs: a qualitative interview study, Disability and Rehabilitation, 2019, p1-8
O'Neill L., Knapp P., Doyle SL., Guinan E., Parker A.,Segurado R., Connolly D., O'Sullivan J., Reynolds JV., Hussey J, 'Patient and family co-developed participant information to improve recruitment rates, retention, and patient understanding in the Rehabilitation Strategies Following Oesophago-gastric and Hepatopancreaticobiliary Cancer (ReStOre II) trial: Protocol for a study within a trial (SWAT) [version 1; peer review: awaiting peer review]', 2019, -
Guinan, E.M., Bennett, A.E., Doyle, S.L., O'Neill, L, Gannon, J., Foley, G., Elliott, J.A., O'Sullivan, J., Reynolds, J.V., & Hussey, J., Measuring the impact of oesophagectomy on physical functioning and physical activity participation: a prospective study, BMC Cancer, 19, (682), 2019
Haberlin C, Broderick J., Guinan E.M, Darker C., Hussey J., O'Donnell D.M., E-Health based intervention to increase physical activity levels in people with cancer: protocol of a feasibility trial in an Irish acute hospital setting, BMJ Open, 9: e024999, 2019
Sanders M.L., Stuckenschneider T, Devenney K.E. Lawlor B., Schneider S, Olde Rikkert M.G.M., NeuroExercise Study Group , ) Real world recruiting of older subjects with mild cognitive impairment for exercise trials: community readiness is pivotal, Journal of Alzheimer's Disease, 62, (2), 2018, p579 - 581
Hussey JM, Yang T, Dowds J, O'Connor L, Reynolds JV, Guinan EM., Quantifying postoperative mobilisation following oesophagectomy., Physiotherapy, 105, (1), 2018, p126 - 133
Guinan EM, Forde C, O'Neill L, Gannon J, Doyle SL, Valkenet K, Trappenburg JCA, van Hillegersberg R, Ravi N, Hussey JM, Reynolds JV., Effect of preoperative inspiratory muscle training on physical functioning following esophagectomy., Diseases of the Esphagus, 32, (32), 2018, pdoy091-
Newton RU, Kenfield SA, Hart NH, Chan JM, Courneya KS, Catto J, Finn SP, Greenwood R, Hughes DC, Mucci L, Plymate SR, Praet SFE, Guinan EM, Van Blarigan EL, Casey O, Buzza M, Gledhill S, Zhang L, Galvão DA, Ryan CJ, Saad F., Intense Exercise for Survival among Men with Metastatic Castrate-Resistant Prostate Cancer (INTERVAL-GAP4): a multicentre, randomised, controlled phase III study protocol., BMJ Open, 8, (5), 2018
Stuckenschneider T, Askew C.D., Rudiger S., Cristina Polidori M., Abeln V, Vogt T, Krome A, Olde Rikkert M, Lawlor B., Schneider S., NeuroExercise Study Group , Cardiorespirataory fitness and cognitive function are positively related among participants with mild and subjective cognitive impairment, Journal of Alzheimer's Disease,, 62, (4), 2018, p1865 - 1875
Guinan, E.M., Doyle, S.L., Bennett, A.E., O'Neill, L, Gannon, J., Elliott, J.A., O'Sullivan, J., Reynolds, J.V., & Hussey, J., Sarcopenia during neoadjuvant therapy for oesophageal cancer: characterising the impact on muscle strength and physical performance, Supportive Care in Cancer, 26, (5), 2018, p1569 - 1576
Valkenet K., Trappenburg T., Ruurda J., Guinan E., Reynolds J.V., Nafteux P., Fontaine M., Rodrigo E., van det Peet D., Hania S., Sosef M., Willms J., Rosman C., Pieters H., Scheepers J., Faber T., Kouwenhoven E., Tinselboer M., Rasanen J., Ryynanen H., Fosselink R., van Hillegersberg R., Backx F. , 'Preoperative inspiratory muscle training in patients undergoing esophagectomy: the results of the PREPARE trial, an international multicenter RCT, British Journal of Surgery, 105, (5), 2018, p502 - 511
Sheill G, Guinan E, O Neill L., Hevey D., Hussey J. , Physical Activity and Advanced Cancer: The views of Oncology and Palliative Care Physicians in Ireland. , Irish Journal of Medical Science, 187, (2), 2018, p337 - 343
Sheill. G., Guinan, E.M., O'Neill L, Hevey, D., Hussey, J. , Physical Activity and Advanced Cancer: The views of Chartered Physiotherapists in Ireland. , Physiotherapy Theory and Practice, 3, 2018, p1 - 8
O'Neill, L. and Moran, J. and Guinan, E.M. and Reynolds, J.V. and Hussey, J., Physical decline and its implications in the management of oesophageal and gastric cancer: a systematic review, Journal of Cancer Survivorship, 12, (4), 2018, p601 - 618
O'Neill, L.M., Guinan, E., Doyle, S.L., Bennett, A.E., Murphy, C., Elliott, J.A., O'Sullivan, J., Reynolds, J.V., Hussey, J., The RESTORE Randomized Controlled Trial: Impact of a multidisciplinary rehabilitative program on cardiorespiratory fitness in esophagogastric cancer survivorship, Annals of Surgery, 268, (5), 2018, p747 - 755
Bennett, A.E., O'Neill, L., Connolly, D., Guinan, E.M., Boland, L., Doyle, S.L., O'Sullivan, J., Reynolds, J.V., & Hussey, J., Patient experiences of a physiotherapy-led multidisciplinary rehabilitative intervention after successful treatment for oesophago-gastric cancer, Supportive Care in Cancer, 26, (8), 2018, p2615 - 2623
Sheill G., Guinan E.M., Peat N., Hussey J , Considerations for Exercise Prescription in Patients with Bone Metastases: A Comprehensive Narrative Review. , Physical Medicine and Rehabilitation , 10, (8), 2018, p843 - 864
Mulcahy S, Prendergast J, Foley G, O'Hare A, Murphy E, Guinan EM, Hussey J, Exercise Rehabilitation services provided by physiotherapy departments in Ireland., Irish Medical Journal , 111, (9), 2018, p818-
Sheill G; Brady L; Guinan E; Hayes B; Casey O; Greene J; Vlajnic T; Cahill F; Van Hemelrijck M; Peat N; Rudman S; Hussey J; Cunningham M; Grogan L; Lynch T; Manecksha R; McCaffrey J; Mucci L; Sheils O; O Leary J; M O Donnell D; McDermott R; Finn S. , The ExPeCT (Exercise, Prostate Cancer and Circulating Tumour Cells) Trial: Study protocol for a randomised controlled trial. , Trials, 18, 2017, p456-
Guinan, E.M., Dowds, J., Donohoe, C., Reynolds, J.V., Hussey, J., The physiotherapist and the esophageal cancer patient: From prehabilitation to rehabilitation, Diseases of the Esophagus, 30, (1), 2017, p1-12
Linda O'Neill, Emer Guinan, Suzanne L Doyle, Jessie A. Elliott, Jacintha O'Sullivan, John V. Reynolds, Juliette Hussey, Rehabilitation Strategies following esophageal cancer (the ReStOre trial): a feasibility study, Diseases of the Esophagus, 30, (5), 2017, p1 - 8
Elliott J.A., Doyle, S.L., Murphy C.F., King S., Guinan E.M., Beddy, P., Narayanasamy, R. (, Sarcopenia: Prevalence, and Impact on Operative and Oncologic Outcomes in the Multimodal Management of Locally Advanced Esophageal Cancer , Annals of Surgery, 266, (5), 2017, p822 - 830
Devenney KE, Sanders ML, Lawlor B, Olde Rikkert MGM, Schneider S; NeuroExercise Study Group, The effects of an extensive exercise programme on the progression of Mild Cognitive Impairment (MCI): study protocol for a randomised controlled trial., BMC Geriatrics, 17, (1), 2017, p75-
Moran, J., Guinan, E., McCormick, P., Larkin, J., Mockler, D., Hussey, J., Moriarty, J., Wilson, F. , Response to: Is prehabilitation limited to preoperative exercise? , Surgery, 162, (1), 2017, p192 - 193
Rudiger S., Stuckenschneider T, Vogt T, Abeln V., Lawlor B., Olde Rikkert M., Schneider S., NeuroExercise Study Group, Cognitive impairment is reflected by an increased difference between and imagined timed up and go performance, Dementia and Geriatric Cognitive Disorders, 44, (1-2), 2017, p55 - 62
Gannon, J.A., Guinan E.M., Doyle S.L., Beddy P., Reynolds J.V., Hussey J. , Reduced Fitness and Physical Functioning are long-term Sequelae after Curative Treatment for Oesophageal Cancer: a Case-Control Study. , Diseases of the Esophagus, 30, (8), 2017, p1 - 7
O'Neill L, Gannon J, Guinan E, Reynolds JV, Hussey J. , Multidisciplinary rehabilitation across the esophageal cancer journey, Journal of Thoracic Diseases, 9, (12), 2017, pE1140 - E1142
Sheill G, Guinan E, Neill LO, Hevey D, Hussey J, The views of patients with metastatic prostate cancer towards physical activity: a qualitative exploration, Supportive Care in Cancer, 26, (6), 2017, p1747 - 1754
Moran, J., Wilson, F., Guinan, E., McCormick, P., Hussey, J., Moriarty, J., The preoperative use of field tests of exercise tolerance to predict postoperative outcome in intra-abdominal surgery: a systematic review, Journal of Clinical Anesthesia, 35, 2016, p446-455
Moran, J., Wilson, F., Guinan, E., McCormick, P., Hussey, J., Moriarty, J., Role of cardiopulmonary exercise testing as a risk-assessment method in patients undergoing intra-abdominal surgery: A systematic review, British Journal of Anaesthesia, 116, (2), 2016, p177-191
Guinan, E.M., Doyle, S.L., O'Neill, L., Dunne, M.R., Foley, E.K., O'Sullivan, J., Reynolds, J.V., Hussey, J., Effects of a multimodal rehabilitation programme on inflammation and oxidative stress in oesophageal cancer survivors: the ReStOre feasibility study, Supportive Care in Cancer, 25, (3), 2016, p749 - 756
Moran J., Guinan E., McCormick P., Larkin J., Mockler D., Hussey J., Moriarty J., Wilson F., The ability of prehabilitation to influence postoperative outcome after intra-abdominal operation: A systematic review and meta-analysis, Surgery (United States), 160, (5), 2016, p1189-1201
Elliott, J.A., Docherty, N.G., Eckhardt, H.-G., Doyle, S.L., Guinan, E.M., Ravi, N., Reynolds, J.V., Roux, C.W.L., Weight Loss, Satiety, and the Postprandial Gut Hormone Response After Esophagectomy: A Prospective Study, Annals of Surgery, 266, (1), 2016, p82 - 90
Moran J, Murphy A, Murphy D, Austin A, Moran D, Cronin C, Guinan E, Hussey J, The energy expenditure of non-weight bearing crutch walking on the level and ascending stairs., Gait & posture, 42, (1), 2015, p23-6
Cahir, C., Guinan, E., Dombrowski, S.U., Sharp, L., Bennett, K., Identifying the determinants of adjuvant hormonal therapy medication taking behaviour in women with stages I-III breast cancer: A systematic review and meta-analysis, Patient Education and Counseling, 98, (12), 2015, p1524-1539
Broderick, J. M. Guinan, E. Donnell, D. M. O' Hussey, J. Tyrell, E. Normand, C., Calculating the costs of an 8-week, physiotherapy-led exercise intervention in deconditioned cancer survivors in the early survivorship period (the PEACH trial), Physiotherapy, 100, (2), 2014, p182 - 184
Valkenet K, Trappenburg JC, Gosselink R, Sosef MN, Willms J, Rosman C, Pieters H, Scheepers JJ, de Heus SC, Reynolds JV, Guinan E, Ruurda JP, Rodrigo EH, Nafteux P, Fontaine M, Kouwenhoven EA, Kerkemeyer M, van der Peet DL, Hania SW, van Hillegersberg R, Backx FJ, Preoperative inspiratory muscle training to prevent postoperative pulmonary complications in patients undergoing esophageal resection (PREPARE study): study protocol for a randomized controlled trial., Trials, 15, (1), 2014, p144
Guinan EM, Connolly EM, Healy LA, Carroll PA, Kennedy MJ, Hussey J , The Development of the Metabolic Syndrome and Insulin Resistance After Adjuvant Treatment for Breast Cancer, Cancer Nursing, Epub ahead of print, 2013
Guinan E., Hussey J., McGarrigle S.A., Healy L.A., O'Sullivan J.N., Bennett K., Connolly E.M., A Prospective Investigation of Predictive and Modifiable Risk Factors for Breast Cancer in Unaffected BRCA1 and BRCA2 Gene Carriers., BMC Cancer, 13, (138), 2013
Guinan, E.M., Connolly, E.M., Hussey J , Exercise training in breast cancer survivors: a review of trials examining anthropometric and obesity-related biomarkers of breast cancer risk, Physical Therapy Reviews , 18, (2), 2013, p79 - 89
Broderick JM, Guinan E, Kennedy MJ, Hollywood D, Courneya KS, Culos-Reed SN, Bennett K, O'Donnell DM, Hussey J, Feasibility and efficacy of a supervised exercise intervention in de-conditioned cancer survivors during the early survivorship phase, Journal of Cancer Survivorship, 7, (4), 2013, p551 - 562
Guinan E, Hussey J, Broderick JM, Lithander FE, O'Donnell D, Kennedy MJ, Connolly EM, The effect of aerobic exercise on metabolic and inflammatory markers in breast cancer survivors-a pilot study., Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 21, (7), 2013, p1983-1992
Guinan EM, Connolly EM, Kennedy MJ, Hussey J., The presentation of metabolic dysfunction and the relationship with energy output in breast cancer survivors: a cross-sectional study, Nutr J. , 12, (1), 2013
Guinan, E.M., Connolly, E.M., Hussey J , Physical Activity and Obesity Related Biomarkers in Breast Cancer Survivors, Physical Therapy Reviews, 18, (3), 2013, p229 - 231
Walsh JM, Hussey J, Guinan E, O' Donnell D, 'Pragmatic randomized controlled trial of individually prescribed exercise versus usual care in a heterogeneous cancer survivor population': a feasibility study PEACH trial: prescribed exercise after chemotherapy., BMC Cancer, 10, (42), 2010
Non-Peer-Reviewed Publications
Promoting Leadership Skills Through Interprofessional Education in, editor(s)Morison S , Leadership: Perception, Influences and Gender Differences, NOVA science publishers, 2017, pp103 - 139, [Guinan E.M. and McGowen E.]
Research Expertise
Description
I am an Assistant Professor in the School of Medicine with responsibility for the Interprofessional Learning programme for the Faculty of Health Sciences. My main research interest is in the role of exercise and physical activity in ameliorating treatment side effects and optimising survivorship for patients with cancer. My work considers both the therapeutic and the physiological impact of exercise programmes. I have a particular interest in the role of exercise for patients with complex cancer presentations including patients with cancer of the gastrointestinal tract and those with advanced disease. I have been awarded >1.7 million in research funding as either principle investigator or co-applicant from external peer-reviewed grants (Health Research Board, Irish Cancer Society, Medical Charities Research Group), external research bursaries (Irish Society of Chartered Physiotherapists) and internal competitions from the Faculty of Health Sciences, Trinity College. I have published over 50 peer reviewed publications and 1 book chapter. In addition, I lead an interprofessional learning research programme across the Faculty of Health Sciences.Projects
- Title
- Preoperative inspiratory muscle training to prevent postoperative pulmonary complications in patients undergoing esophageal resection (the PREPARE study)
- Summary
- This multi-centre international trial is examining the effect of a preoperative programme of inspiratory muscle training on post-operative pulmonary outcomes in patients undergoing oesophagectomy
- Title
- Rehabilitative Strategies Following Oesophageal Cancer (ReStOre trial)
- Summary
- This project comprises two studies; 1)a longitudinal assessment of the effect of curative treatment for oesopahgeal cancer on physical performance and 2) an investigation of the feasibility and efficacy of a rehabilitative programme of exercise and dietary intervention following oesophageal cancer treatment completion.
- Funding Agency
- Health Research Board (HRB)
- Date From
- Oct 2014
- Title
- Knowledge Exchange and Dissemination: Community Exercise
- Summary
- This research programme aims to enable patients who are participating in exercise training programmes at the Wellcome Trust-HRB Clinical Research Facility at St James's Hospital to exercise locally by addressing patient-reported barriers to community exercise participation
- Funding Agency
- Health Research Board
- Date From
- 01.01.2018
- Date To
- 31.12.2018
- Title
- Rehabilitation Strategies following Oesophagogastric and Hepatopancreaticobiliary Cancer
- Funding Agency
- Health Research Board
- Date From
- 01.05.2019
- Date To
- 01.05.2023
- Title
- Preoperative Exercise to Improve Fitness in Patients Undergoing Complex Surgery for Cancer of the Lung or Oesophagus
- Funding Agency
- MRCG-HRB
- Date From
- 07.12.2018
- Date To
- 06.02.2022
- Title
- Exercise prescription in patients with bone metastases: identifying clinical tools to overcome clinician concerns regarding skeletal related events.
- Funding Agency
- Irish Cancer Society and the All Ireland Institute of Hospice and Palliative Care Research Award.
- Date From
- 01.02.2019
- Date To
- 01.02.2021
Recognition
Representations
2021 - present: Member of the Physical Activity and Exercise Subgroup at the National Cancer Control Programme
2022 - Member of the Irish Psycho-Social Oncology Network (IPSON) Steering Committee representing Cancer Rehabilitation
Co-chair of the Irish Network of Healthcare Educators Special Interest Group in Interprofessional Education and Collaborative Practice
Memberships
Irish Society of Chartered Physiotherapists (ISCP)
CORU Physiotherapy Registration Board