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Dr. Kathy Gately
Clinical Senior Lecturer, Clinical Medicine

Biography

Dr. Kathy Gately graduated with a BSc from University College Dublin and a PhD from the Department of Biochemistry, National University of Ireland Galway in 2000. During her PhD she spent six months at the University of California Los Angeles. She then worked as a postdoctoral fellow in the Dept. of Haematology with Prof. Mark Lawler and Prof. Shaun McCann where she carried out research on the novel targeted agent Imatinib in CML patients. In 2004, Dr. Gately was appointed as a Clinical Lecturer with Prof. Ken O'Byrne in the Dept. of Clinical Medicine. She was instrumental in the establishment of the Lung Cancer Biobank which supports research and clinical trials within the Translational Oncology Research Group (TORG). Dr. Gately has previously supervised 4 MD, 2 PhD and 12 MSc students. The main focus of Dr. Gately's research group is (i) the identification of novel prognostic/predictive biomarkers and therapeutic targets to improve treatment options for patients with cancer (ii) elucidating mechanisms of resistance to targeted therapies, in particular PI3K and EGFR inhibitors (iii) the role of the liquid biopsy in cancer diagnosis and treatment. Dr. Gately delivers lectures to undergraduate students in Molecular Medicine as well as the MSc in Molecular Medicine and Translational Oncology. She is editor of a recent book entitled: "Lung Cancer: A Comprehensive Review" Nova Publishers 2013. Dr. Gately is currently leading a research collaboration with Inflection Biosciences Ltd, an Irish company developing targeted small molecule treatments for cancer. The research examines the effectiveness of a panel of the company's targeted PIM kinase inhibitors in the treatment of thoracic malignancy. In particular, solid tumours that have become resistant to other forms of treatment. This research is supported in part by an Innovation Partnership Program award from Enterprise Ireland (EI).

Publications and Further Research Outputs

Peer-Reviewed Publications

Luszczak S, Kumar C, Sathyadevan VK, Simpson BS, Gately KA, Whitaker HC, Heavey S., PIM kinase inhibition: co-targeted therapeutic approaches in prostate cancer., Signal Transduct Target Ther., 5, (7), 2020 Journal Article, 2020 DOI

Toomey S, Carr A, Mezynski MJ, Elamin Y, Rafee S, Cremona M, Morgan C, Madden S, Abdul-Jalil KI, Gately K, Farrelly A, Kay EW, Kennedy S, O'Byrne K, Grogan L, Breathnach O, Morris PG, Eustace AJ, Fay J, Cummins R, O'Grady A, Kalachand R, O'Donovan N, Kelleher F, O'Reilly A, Doherty M, Crown J, Hennessy BT, Identification and clinical impact of potentially actionable somatic oncogenic mutations in solid tumor samples., Journal of Translational Medicine, 18, (1), 2020, p[1-99] Journal Article, 2020 DOI TARA - Full Text

Malone T, Schäfer L, Simon N, Heavey S, Cuffe S, Finn S, Moore G, Gately K., Current perspectives on targeting PIM kinases to overcome mechanisms of drug resistance and immune evasion in cancer., Pharmacology and Therapeutics, 207, 2020 Journal Article, 2020 DOI

Gaule P, Mukherjee N, Corkery B, Eustace AJ, Gately K, Roche S, O'Connor R, O'Byrne KJ, Walsh N, Duffy MJ, Crown J, O'Donovan N., Dasatinib Treatment Increases Sensitivity to c-Met Inhibition in Triple-Negative Breast Cancer Cells., Cancers, 11, (4), 2019 Journal Article, 2019 DOI

Thunnissen E, Kerr KM, Dafni U, Bubendorf L, Finn SP, Soltermann A, Biernat W, Cheney R, Verbeken E, Warth A, Marchetti A, Speel EM, Pokharel S, Quinn AM, Monkhorst K, Navarro A, Madsen LB, Tsourti Z, Geiger T, Kammler R, Peters S, Stahel RA; European Thoracic Oncology Platform Lungscape Consortium., Programmed death-ligand 1 expression influenced by tissue sample size. Scoring based on tissue microarrays' and cross-validation with resections, in patients with, stage I-III, non-small cell lung carcinoma of the European Thoracic Oncology Platform Lungscape cohort., Modern Pathology, 2019 Journal Article, 2019

Heavey S, Dowling P, Moore G, Barr MP, Kelly N, Maher SG, Cuffe S, Finn SP, O'Byrne KJ, Gately K., Development and characterisation of a panel of phosphatidylinositide 3-kinase - mammalian target of rapamycin inhibitor resistant lung cancer cell lines., Scientific Reports, 8, (1), 2018, p1652- Journal Article, 2018 DOI TARA - Full Text

Kerr KM, Dafni U, Schulze K, Thunnissen E, Bubendorf L, Hager H, Finn S, Biernat W, Vliegen L, Losa JH, Marchetti A, Cheney R, Warth A, Speel EJ, Blackhall F, Monkhorst K, Jantus Lewintre E, Tischler V, Clark C, Bertran-Alamillo J, Meldgaard P, Gately K, Wrona A, Vandenberghe P, Felip E, De Luca G, Savic S, Muley T, Smit EF, Dingemans AC, Priest L, Baas P, Camps C, Weder W, Polydoropoulou V, Geiger TR, Kammler R, Sumiyoshi T, Molina MA, Shames DS, Stahel RA, Peters S, ETOP Lungscape Consortium., Prevalence and clinical association of gene mutations through multiplex mutation testing in patients with NSCLC: results from the ETOP Lungscape Project., Annals of oncology : official journal of the European Society for Medical Oncology, 29, (1), 2018, p200-208 Journal Article, 2018 DOI

Collins, D.M. and Gately, K. and Hughes, C. and Edwards, C. and Davies, A. and Madden, S.F. and O'Byrne, K.J. and O'Donovan, N. and Crown, J., Tyrosine kinase inhibitors as modulators of trastuzumab-mediated antibody-dependent cell-mediated cytotoxicity in breast cancer cell lines, Cellular Immunology, 319, 2017, p35-42 Journal Article, 2017 DOI

Adams, M.N. and Burgess, J.T. and He, Y. and Gately, K. and Snell, C. and Zhang, S.-D. and Hooper, J.D. and Richard, D.J. and O'Byrne, K.J., Expression of CDCA3 Is a Prognostic Biomarker and Potential Therapeutic Target in Nonâ€"Small Cell Lung Cancer, Journal of Thoracic Oncology, 12, (7), 2017, p1071-1084 Journal Article, 2017 DOI

Hutchinson RA, Coleman HG, Gately K, Young V, Nicholson S, Cummins R, Kay E, Hynes SO, Dunne PD, Senevirathne S, Hamilton PW, McArt DG, Longley DB, IHC-based subcellular quantification provides new insights into prognostic relevance of FLIP and procaspase-8 in non-small-cell lung cancer, Cell Death Discovery, 14, (3), 2017, p17050- Journal Article, 2017

Burgess J.T, Bolderson E, Adams M.N, Baird A.-M, Zhang S.-D, Gately K.A, Umezawa K, O'Byrne K.J, Richard D.J, Activation and cleavage of SASH1 by caspase-3 mediates an apoptotic response, Cell Death and Disease, 7, (11), 2016, pe2469- Journal Article, 2016 URL TARA - Full Text DOI

Hallinan N, Finn S, Cuffe S, Rafee S, O'Byrne K, Gately K, Targeting the fibroblast growth factor receptor family in cancer, Cancer Treatment Reviews, 46, 2016, p51 - 62 Journal Article, 2016 DOI URL

Cathcart M.-C, Useckaite Z, Drakeford C, Semik V, Lysaght J, Gately K, O'Byrne K.J, Pidgeon G.P, Anti-cancer effects of baicalein in non-small cell lung cancer in-vitro and in-vivo, BMC Cancer, 16, (1), 2016, p707- Journal Article, 2016 URL DOI TARA - Full Text

Heavey S, Cuffe S, Finn S, Young V, Ryan R, Nicholson S, Leonard N, McVeigh N, Barr M, O'Byrne K, Gately K, In pursuit of synergy: An investigation of the PI3K/mTOR/MEK co-targeted inhibition strategy in NSCLC, Oncotarget, 7, (48), 2016, p79526 - 79543 Journal Article, 2016 TARA - Full Text DOI URL

O'Callaghan DS, Tumour islet Foxp3+ T-cell infiltration predicts poor outcome in nonsmall cell lung cancer., European Respiratory Journal, 46, (6), 2015, p1762 - 1772 Journal Article, 2015 DOI

Elamin YY et al, Thymidine phosphorylase in cancer; enemy or friend?, Cancer Microenvironment, 9, (1), 2015, p33 - 43 Journal Article, 2015

Barr, M.P., Gray, S.G., Gately, K., (...), Pidgeon, G.P., O'Byrne, K.J., Vascular endothelial growth factor is an autocrine growth factor, signaling through neuropilin-1 in non-small cell lung cancer, Molecular Cancer, 14, (1), 2015, p45- Journal Article, 2015 TARA - Full Text DOI

Heavey S, O'Byrne KJ, Gately K, Strategies for co-targeting the PI3K/AKT/mTOR pathway in NSCLC., Cancer treatment reviews, 40, (3), 2014, p445-56 Journal Article, 2014 DOI

Dowling P, Pollard D, Larkin A, Henry M, Meleady P, Gately K, O'Byrne K, Barr MP, Lynch V, Ballot J, Crown J, Moriarty M, O'Brien E, Morgan R, Clynes M, Abnormal levels of heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) in tumour tissue and blood samples from patients diagnosed with lung cancer., Molecular bioSystems, 2014 Journal Article, 2014 DOI

Al-Alao BS, Gately K, Nicholson S, McGovern E, Young VK, O'Byrne KJ, Prognostic impact of vascular and lymphovascular invasion in early lung cancer., Asian cardiovascular & thoracic annals, 22, (1), 2014, p55-64 Journal Article, 2014 DOI

Peters S, Weder W, Dafni U, Kerr KM, Bubendorf L, Meldgaard P, O'Byrne KJ, Wrona A, Vansteenkiste J, Felip E, Marchetti A, Savic S, Lu S, Smit E, Dingemans AM, Blackhall FH, Baas P, Camps C, Rosell R, Stahel RA, Lungscape: resected non-small-cell lung cancer outcome by clinical and pathological parameters., Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 9, (11), 2014, p1675-84 Journal Article, 2014 DOI

Heavey S, Godwin P, Baird AM, Barr MP, Umezawa K, Cuffe S, Finn SP, O'Byrne KJ, Gately K, Strategic targeting of the PI3K-NF"B axis in cisplatin-resistant NSCLC., Cancer biology & therapy, 15, (10), 2014, p1367-77 Journal Article, 2014 DOI

Cathcart MC, Gately K, Cummins R, Drakeford C, Kay EW, O'Byrne KJ, Pidgeon GP, Thromboxane synthase expression and correlation with VEGF and angiogenesis in non-small cell lung cancer., Biochimica et biophysica acta, 1842, (5), 2014, p747-55 Journal Article, 2014 DOI

Barr M, Souan L, MacGabhann P, Muller J, Al-Ashhab M, Jasser M, Hamza K, Al-Hassoon S, Kuhn U, Infante D, Lawlor D, Kately K, Amireh E, O'Byrne K, Sughayer MA., The establishment of an ISO compliant cancer biobank for Jordan and its neighboring countries through knowledge transfer and training., Biopreservation and biobanking, 12, (1), 2014, p3-12 Journal Article, 2014 DOI TARA - Full Text

Shikhrakab H, Elamin YY, O'Brien C, Gately K, Finn S, O'Byrne K, Osman N, Epidermal growth factor receptor (EGFR) mutation testing, from bench to practice: a single institute experience., Irish medical journal, 107, (7), 2014, p201-4 Journal Article, 2014

Gately K, Forde L, Cuffe S, Cummins R, Kay EW, Feuerhake F, O'Byrne KJ, High coexpression of both EGFR and IGF1R correlates with poor patient prognosis in resected non-small-cell lung cancer., Clinical lung cancer, 15, (1), 2014, p58-66 Journal Article, 2014 DOI

Rani S, Gately K, Crown J, O'Byrne K, O'Driscoll L, Global analysis of serum microRNAs as potential biomarkers for lung adenocarcinoma., Cancer Biology & Therapy, 14, (12), 2013, p1104 - 1112 Journal Article, 2013 TARA - Full Text DOI URL

Yuen HF, Gunasekharan VK, Chan KK, Zhang SD, Platt-Higgins A, Gately K, O'Byrne K, Fennell DA, Johnston PG, Rudland PS, El-Tanani M, RanGTPase: a candidate for Myc-mediated cancer progression., Journal of the National Cancer Institute, 105, (7), 2013, p475-88 Journal Article, 2013

Al-Alao BS, O'Callaghan DS, Gately K, Nicholson S, Coate LE, O'Connell F, McGovern E, O'Byrne KJ, Young VK, Surgical resection for non-small cell lung cancer: clinical features and outcomes for a consecutive series at an Irish tertiary referral centre., Irish journal of medical science, 182, (2), 2013, p217-25 Journal Article, 2013

Godwin P, Baird AM, Heavey S, Barr MP, O'Byrne KJ, Gately K., Targeting nuclear factor-kappa B to overcome resistance to chemotherapy., Frontiers in oncology, 3, 2013, p120 Journal Article, 2013 DOI TARA - Full Text

Riley JS, Hutchinson R, McArt DG, Crawford N, Holohan C, Paul I, Van Schaeybroeck S, Salto-Tellez M, Johnston PG, Fennell DA, Gately K, O'Byrne K, Cummins R, Kay E, Hamilton P, Stasik I, Longley DB, Prognostic and therapeutic relevance of FLIP and procaspase-8 overexpression in non-small cell lung cancer., Cell death & disease, 4, 2013, pe951 Journal Article, 2013 DOI

Gately K, O'Flaherty J, Cappuzzo F, Pirker R, Kerr K, O'Byrne K, The role of the molecular footprint of EGFR in tailoring treatment decisions in NSCLC., Journal of clinical pathology, 65, (1), 2012, p1-7 Journal Article, 2012 DOI

Gately K, Al-Alao B, T Dhillon Mauri F, Cuffe S, Seckl M, O'Byrne K, Overexpression of the mammalian target of rapamycin (mTOR) and angioinvasion are poor prognostic factors in early stage NSCLC: a verification study., Lung cancer (Amsterdam, Netherlands), 75, (2), 2012, p217-22 Journal Article, 2012

Gately K, Kerr K, O'Byrne K, Design, construction, and analysis of cell line arrays and tissue microarrays for gene expression analysis., Methods in molecular biology (Clifton, N.J.), 784, 2011, p139-53 Journal Article, 2011 DOI

Gately K, Collins I, Forde L, Al-Alao B, Young V, Gerg M, Feuerhake F, O'Byrne K, A role for IGF-1R-targeted therapies in small-cell lung cancer?, Clinical lung cancer, 12, (1), 2011, p38-42 Journal Article, 2011

Paul I, Savage KI, Blayney JK, Lamers E, Gately K, Kerr K, Sheaff M, Arthur K, Richard DJ, Hamilton PW, James JA, O'Byrne KJ, Harkin DP, Quinn JE, Fennell DA, PARP inhibition induces BAX/BAK-independent synthetic lethality of BRCA1-deficient non-small cell lung cancer., The Journal of pathology, 224, (4), 2011, p564-74 Journal Article, 2011 DOI

Cathcart MC, Gray SG, Baird AM, Boyle E, Gately K, Kay E, Cummins R, Pidgeon GP, O'Byrne KJ, Prostacyclin synthase expression and epigenetic regulation in nonsmall cell lung cancer., Cancer, 117, (22), 2011, p5121-32 Journal Article, 2011 DOI

Cathcart MC, Gately K, Cummins R, Kay E, O'Byrne KJ, Pidgeon GP, Examination of thromboxane synthase as a prognostic factor and therapeutic target in non-small cell lung cancer., Molecular cancer, 10, 2011, p25 Journal Article, 2011 DOI

Pirker R, Consensus for EGFR mutation testing in non-small cell lung cancer: results from a European workshop., Journal of Thoracic Oncology, 2010 Journal Article, 2010

Wilson, TR, Redmond, KM, McLaughlin, KM, Crawford, N, Gately, K, O'Byrne, K, Le-Clorrenec, C, Holohan, C, Fennell, DA, Johnston, PG, Longley, DB, Procaspase 8 overexpression in non-small-cell lung cancer promotes apoptosis induced by FLIP silencing, CELL DEATH AND DIFFERENTIATION, 16, (10), 2009, p1352-1361 Journal Article, 2009 DOI

Field JK, Liloglou T, Niaz A, Bryan J, Gosney JR, Giles T, Brambilla C, Brambilla E, Vesin A, Timsit JF, Hainaut P, Martinet Y, Vignaud JM, Thunnissen FB, Prinsen C, Snijders PJ, Smit EF, Sozzi G, Roz L, Risch A, Becker HD, Elborn JS, Magee ND, Montuenga LM, Pajares MJ, Lozano MD, O'Byrne KJ, Harrison DJ, Niklinski J, Cassidy A, EUELC project: a multi-centre, multipurpose study to investigate early stage NSCLC, and to establish a biobank for ongoing collaboration., The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology, 34, (6), 2009, p1477-86 Journal Article, 2009 DOI

Al-Sarraf, N., Gately, K., Lucey, J., Aziz, R., Doddakula, K., Wilson, L., McGovern, E., Young, V., Clinical implication and prognostic significance of standardised uptake value of primary non-small cell lung cancer on positron emission tomography: analysis of 176 cases, European Journal of Cardio-thoracic Surgery, 34, (4), 2008, p892-897 Journal Article, 2008

Al-Sarraf, N., Gately, K., Lucey, J., Wilson, L., McGovern, E., Young, V., Lymph node staging by means of positron emission tomography is less accurate in non-small cell lung cancer patients with enlarged lymph nodes: Analysis of 1145 lymph nodes, Lung Cancer, 60, (1), 2008, p62-68 Journal Article, 2008

Al-Sarraf, N., Gately, K., Lucey, J., Wilson, L., McGovern, E., Young, V., Mediastinal lymph node staging by means of positron emission tomography is less sensitive in elderly patients with non-small-cell lung cancer, Clinical Lung Cancer, 9, (1), 2008, p39-43 Journal Article, 2008

Gray, SG, Al-Sarraf, N, Baird, AM, Gately, K, McGovern, E, O'Byrne, KJ, Transcriptional regulation of IRS5/DOK4 expression in non-small-cell lung cancer cells., Clinical lung cancer, 9, (6), 2008, p367-374 Journal Article, 2008 DOI

Al-Sarraf, N., Aziz, R., Gately, K., Lucey, J., Wilson, L., McGovern, E., Young, V., Pattern and predictors of occult mediastinal lymph node involvement in non-small cell lung cancer patients with negative mediastinal uptake on positron emission tomography, European Journal of Cardio-thoracic Surgery, 33, (1), 2008, p104-109 Journal Article, 2008

Al-Sarraf, N., Aziz, R., Doddakula, K., Gately, K., Wilson, L., McGovern, E., Young, V., Factors causing inaccurate staging of mediastinal nodal involvement in non-small cell lung cancer patients staged by positron emission tomography, Interactive Cardiovascular and Thoracic Surgery, 6, (3), 2007, p350-353 Journal Article, 2007

Doddakula, K., Al-Sarraf, N., Gately, K., Hughes, A., Tolan, M., Young, V., McGovern, E., Predictors of acute renal failure requiring renal replacement therapy post cardiac surgery in patients with preoperatively normal renal function, Interactive Cardiovascular and Thoracic Surgery, 6, (3), 2007, p314-318 Journal Article, 2007

Duggan, E., Caraher, E., Gately, K., O'Dwyer, M., McGovern, E., Kelleher, D., McManus, R., Ryan, T., Tumor necrosis factor-" and interleukin-10 gene expression in peripheral blood mononuclear cells after cardiac surgery, Critical Care Medicine, 34, (8), 2006, p2134-2139 Journal Article, 2006

S. R. McCann, K. Gately, E. Conneally and M. Lawler, Molecular response to imatinib mesylate following relapse after allogeneic SCT for CML, Blood, 101, (3), 2003, p1200-1 Journal Article, 2003 URL

Gately, K., McElwaine, S., O'Connor, L., McCann, S., Hollywood, D., Cotter, T., Lawler, M., In vitro treatment of CML cells with antisense oligonucleotides against BCR-ABL; Requirement for an efficient delivery system, Blood, 96, (11 PART II), 2000 Journal Article, 2000

Non-Peer-Reviewed Publications

Gaule P, Dasatinib, Cancers, 2019 Journal Article, 2019

Gately K, Advancing the treatment of non-small cell lung cancer - a combination approach, Cancer Professional, 2018 Journal Article, 2018

Kathy Gately, Lung Cancer : A Comprehensive Overview, First, New York U.S., Nova Science Publishers Inc, 2013 Book, 2013

Research Expertise

Keywords

Bioinformatics; Biological Sciences; Biology; Biomedical sciences; Biostatistical methods; Breast cancer; Cancer genetics and cell biology including metastasis; Cardiothoracic surgery; Cell Death; Cellular Biology; Clinical genetics; Clinical research, trials; Cytogenetics; Diagnostic bioimaging; Gene targeting in breast cancer; Gene therapy; Gene transcription in human cancer; Genetic/Molecular epidemiology; Genetics; Haemotology; Human genetics; Imaging Techniques; Immunoassays; Instrumentation development; Medical technology; Medicine; Molecular Biology; Molecular Genetics; Monoclonal antibodies; Natural Sciences; Quantitative and molecular genetics; Regulatory methods of gene expression; RNA processing, stability and degradation; Stem Cell Biology; Stem Cell biology and hematopoiesis; Systematic Biology; Therapeutic and Clinical oncology; Tumour immunology and immunotherapy

Recognition

Memberships

AACR

ETOP

BTOG

ESBB

IASLC

ESMO

Irish Thoracic Society (ITS)

ERS