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Dr. Orla Franklin
Clinical Senior Lecturer, Paediatrics

Publications and Further Research Outputs

Peer-Reviewed Publications

Smith A, Bussmann N, Levy P, Franklin O, McCallion N, El-Khuffash A, Comparison of left ventricular rotational mechanics between term and extremely premature infants over the first week of age., Open heart, 2021 Journal Article, 2021

Breatnach CR, McGuinness J, Ng LY, Franklin O, Redmond M, Nölke L, McMahon C, Oslizlok P, Walsh K, Kenny D, Procedural technique for hybrid pulmonary valve replacement in infants and small children., European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2021 Journal Article, 2021

Smith A, Franklin O, McCallion N, Breatnach F, El-Khuffash A, Effect of Gestational Diabetes Mellitus on Neonatal Myocardial Function., Neonatology, 2021 Journal Article, 2021

Bussmann N, Smith A, Breatnach CR, McCallion N, Cleary B, Franklin O, McNamara PJ, El-Khuffash A, Patent ductus arteriosus shunt elimination results in a reduction in adverse outcomes: a post hoc analysis of the PDA RCT cohort., Journal of perinatology : official journal of the California Perinatal Association, 2021 Journal Article, 2021

McHugh A, Breatnach C, Bussmann N, Franklin O, El-Khuffash A, Breathnach FM, Prenatal prediction of neonatal haemodynamic adaptation after maternal hyperoxygenation., BMC pregnancy and childbirth, 2020 Journal Article, 2020

McHugh A, Franklin O, El-Khuffash A, Breathnach F. , 'Can sonographic assessment of pulmonary vascular reactivity following maternal hyperoxygenation predict neonatal pulmonary hypertension? (HOTPOT study protocol). ', Contemp Clin Trials Commun. 2020;19:100610., 2020, - Protocol or guideline, 2020

Niamh Lagan, Dean Huggard, Fiona Mc Grane, Timothy Ronan Leahy, Orla Franklin, Edna Roche, David Webb, Aengus O'Maricaigh, Des Cox, Afif Elkuffash, Peter Greally, Joanne Balfe, Eleanor J Molloy, Multiorgan involvement and management in children with Down Syndrome, Acta Paediatrica, (1), 2020 Journal Article, 2020 DOI

McHugh A, El-Khuffash A, Franklin O, Breathnach FM, Calling into question the future of hyperoxygenation in pregnancy., European journal of obstetrics, gynecology, and reproductive biology, 2020 Journal Article, 2020

Smith A, Molloy E, Miletin J, Curley A, Balfe J, Orla F, EL-Khuffash A, 'Longitudinal assessment of cardiac function in infants with Down's syndrome using novel echocardiography techniques-project protocol. ', HRB Open Res 2020, 3:77, 2020, - Protocol or guideline, 2020

El-Khuffash A, Bussmann N, Breatnach CR, Smith A, Tully E, Griffin J, McCallion N, Corcoran JD, Fernandez E, Looi C, Cleary B, Franklin O, McNamara PJ, 'Early targeted patent ductus arteriosus treatment in premature neonates using a risk based severity score: study protocol for a randomised controlled trial (PDA RCT). ', HRB Open Res 2020, HRB Open Res 2020, 2020, - Protocol or guideline, 2020

El-Khuffash A, Bussmann N, Breatnach CR, Smith A, Tully E, Griffin J, McCallion N, Corcoran JD, Fernandez E, Looi C, Cleary B, Franklin O, McNamara PJ, A Pilot Randomized Controlled Trial of Early Targeted Patent Ductus Arteriosus Treatment Using a Risk Based Severity Score (The PDA RCT)., The Journal of pediatrics, 2020 Journal Article, 2020

Dean Huggard, Lynne Kelly, Emer Ryan, Fiona McGrane, Niamh Lagan, Edna Roche, Joanne Balfe, T. Ronan Leahy, Orla Franklin, Derek G. Doherty, Eleanor J. Molloy, Increased systemic inflammation in children with Down syndrome, Cytokine, 127, 2020, p154938 Journal Article, 2020 DOI

Bussmann N, Franklin O, McCallion N, McNamara PJ, El-Khuffash A, The impact preload on left ventricular three-plane deformation measurements in extremely premature infants., Early human development, 2020 Journal Article, 2020

Lynch Á, Ng L, Lawlor P, Lavelle M, Gardner F, Breatnach C, McMahon CJ, Franklin O, Cyanotic Congenital Heart Disease Modes of Presentation and Prenatal Detection, Irish medical journal, 2019 Journal Article, 2019

Cappelleri A, Bussmann N, Harvey S, Levy PT, Franklin O, El-Khuffash A, Myocardial function in late preterm infants during the transitional period: comprehensive appraisal with deformation mechanics and non-invasive cardiac output monitoring., Cardiology in the young, 2019 Journal Article, 2019

Daly A, Franklin O, Nölke L, Congenital Atrial Haemangioma, Irish medical journal, 2019 Journal Article, 2019

Vigano G, McMahon CJ, Walsh K, Oslizlok P, Franklin O, Nolke L, Redmond JM, Byrne J, McGuinness JG, High-risk Fontan completion patients achieve low perioperative risk and benefit from cavopulmonary connection 7 years out"., European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2019 Journal Article, 2019

Breatnach CR, Bussmann N, Levy PT, Vincent DF, Malone FD, McCallion N, Franklin O, El-Khuffash A, Postnatal Myocardial Function in Monochorionic Diamniotic Twins with Twin-to-Twin Transfusion Syndrome following Selective Laser Photocoagulation of the Communicating Placental Vessels., Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2019 Journal Article, 2019

McHugh A, El-Khuffash A, Bussmann N, Doherty A, Franklin O, Breathnach F, Hyperoxygenation in pregnancy exerts a more profound effect on cardiovascular hemodynamics than is observed in the nonpregnant state., American journal of obstetrics and gynecology, 2019 Journal Article, 2019

Breatnach CR, Aggarwal V, Al-Alawi K, McMahon CJ, Franklin O, Prendiville T, Oslizlok P, Walsh K, Qureshi AM, Kenny D, Percutaneous axillary artery approach for ductal stenting in critical right ventricular outflow tract lesions in the neonatal period., Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2019 Journal Article, 2019

O'Leary D, O'Connor C, Nertney L, MacDermott EJ, Mullane D, Franklin O, Killeen OG, Juvenile systemic lupus erythematosus presenting as pancarditis., Pediatric rheumatology online journal, 2019 Journal Article, 2019

Patel MD, Breatnach CR, James AT, Choudhry S, McNamara PJ, Jain A, Franklin O, Hamvas A, Mertens L, Singh GK, El-Khuffash A, Levy PT, Echocardiographic Assessment of Right Ventricular Afterload in Preterm Infants: Maturational Patterns of Pulmonary Artery Acceleration Time Over the First Year of Age and Implications for Pulmonary Hypertension., Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2019 Journal Article, 2019

Ventricular Septal Defect in, editor(s)Professor A John Camm Professor Thomas F Luscher Professor Patrick Serruys Professor Gerald Maurer , European Society of Cardiology Textbook of Cardiovascular Medicine- 3rd Edition, Oxford , Oxford University Press, 2019, ppChapter 17.20 , [Orla Franklin] Book Chapter, 2019

Bussmann N, Smith A, Cappelleri A, Levy PT, McCallion N, Franklin O, El-Khuffash A, Circumferential and radial deformation assessment in premature infants: Ready for primetime?, Echocardiography (Mount Kisco, N.Y.), 2019 Journal Article, 2019

Bussmann N, Smith A, Cappelleri A, Levy P, McCallion N, Franklin O, EL-Khuffash A , Circumferential and Radial Deformation Assessment in Premature Infants: Ready for Primetime?. , 3rd Congress of joint European Neonatal Societies (jENS),, , Maastricht, The Netherlands, 2019, 2019 Oral Presentation, 2019

Bussman N, El-Khuffash A, Breathnach C, McCallion N, Franklin O, Singh GK, Levy PT. , Right Ventricular and Pulmonary Vascular Coupling is influenced by Left Ventricular Diastolic Function in Premature Infants. , 3rd Congress of joint European Neonatal Societies (jENS),, , Maastricht, The Netherlands, 2019 Oral Presentation, 2019

Bussmann N, Smith A, Cappelleri A, Levy P, McCallion N, Franklin O, EL-Khuffash A , Circumferential and Radial Deformation Assessment in Premature Infants: Ready for Primetime?. , 3rd Congress of joint European Neonatal Societies (jENS),, , Maastricht, The Netherlands, 2019 Oral Presentation, 2019

Breatnach CR, Bussmann N, Smith A, Levy P, McCallion N, Franklin O, El-Khuffash A, Cardiac mechanics in infants with Down syndrome in the early neonatal period., Journal of perinatology : official journal of the California Perinatal Association, 2019 Journal Article, 2019

Bussmann N, Smith A, Cappelleri A, McCallion N, Franklin O, EL-Khuffash A , The Relationship Between Left Ventricular Systolic Longitudinal Deformation Measurements and Preload in Premature Infants, 3rd Congress of joint European Neonatal Societies (jENS),, , Maastricht, The Netherlands, 2019 Oral Presentation, 2019

Deliu AG, Sanneerappa PBJ, Franklin O, Letshwiti J, Sodium nitroprusside, a lifesaving treatment for neonatal hypertension: an Irish experience., BMJ case reports, 2018 Journal Article, 2018

Tulloh RMR, Mayon-White R, Harnden A, Ramanan AV, Tizard EJ, Shingadia D, Michie CA, Lynn RM, Levin M, Franklin OD, Craggs P, Davidson S, Brogan PA, Kawasaki disease: a prospective population survey in the UK and Ireland from 2013 to 2015., Archives of disease in childhood, 2018 Journal Article, 2018

EL-Khuffash A, McNamara PJ, Breatnach CR, Bussmann N, Smith A, Feeney O, Tully E, Griffin J, de Boode W, Creary B, Franklin O, Dempsey E. , 'The use of milrinone in neonates with persistent pulmonary hypertension of the newborn - a randomised controlled trial pilot study (MINT 1): study protocol and review of literature. ', Matern Health Neonatol Perinatol. 2018 Dec 3;4:24. , 2018, - Protocol or guideline, 2018

McHugh A, Dwyer L, Breathnach C, Franklin O El-Khuffash A, Breathnach F. , Changes in maternal haemodynamics in response to hyperoxygenation in the third trimester. , British Maternal Fetal Medicine Society Brighton 2018 , Brighton 2018 , 2018 Oral Presentation, 2018

McHugh A, Breathnach C, Dwyer L, Tully E, Franklin O, Breathnach F. , Hyperoxygenation Therapy in the Third Trimester leads to haemodynamic changes in the maternal circulation. , Society of Maternal and Fetal Medicine, Dallas 2018, 2018 Oral Presentation, 2018

Bussmann N, Breatnach C, Levy PT, McCallion N, Franklin O, El-Khuffash A, Early diastolic dysfunction and respiratory morbidity in premature infants: an observational study., Journal of perinatology : official journal of the California Perinatal Association, 2018 Journal Article, 2018

Bussmann N, El-Khuffash A, Breatnach CR, McCallion N, Franklin O, Singh GK, Levy PT, Left ventricular diastolic function influences right ventricular - Pulmonary vascular coupling in premature infants., Early human development, 2018 Journal Article, 2018

McHugh A, Breathnach C, Dwyer L, Tylly E, Franklin O, El Khuffash A, Breathnach F. , The effect of maternal hyperoxygenation on fetal pulmonary vasoreactivity and on blood flow patterns in the umbilical artery and middle cerebral artery in pregnancy. , Society of Maternal and Fetal Medicine, Dallas 2018, 2018 Oral Presentation, 2018

Bussmann N, Smith A, Cappelleri A, Levy P, McCallion N, Franklin O, EL-Khuffash A , Early Diastolic Dysfunction and respiratory Morbidity in Premature Infants: an Observational Study. , PAN America Haemodynamic Conference, , Toronto Canada, 2018 Oral Presentation, 2018

Walsh N, Breathnach C, El-Khuffash A, Franklin O, Corcoran JD, The utility of routine echocardiography in newborn infants with a persistent oxygen requirement, Irish medical journal, 2018 Journal Article, 2018

CR. Breatnach, A. EL-Khuffash, AT. James, N. McCallion, O. Franklin. , Serial Measures of Cardiac Performance Using Tissue Doppler Imaging Velocity in Preterm Infants Less Than 29 Weeks Gestations. , Paediatric Academic Societies meeting, ., San Francisco 2017, 2017 Oral Presentation, 2017

E. Fitzgerald , G. McGauran , J. Walsh , C. Breatnach , A. EL-Khuffash , O. Franklin , F. Breathnach , Perinatal management of prenatally-identified ductal dependent congenital heart disease. , EAPS, Geneva, Switzerland , Geneva, Switzerland , 2017 Oral Presentation, 2017

Semberova J, Sirc J, Miletin J, Kucera J, Berka I, Sebkova S, O'Sullivan S, Franklin O, Stranak Z, Spontaneous Closure of Patent Ductus Arteriosus in Infants "1500 g., Pediatrics, 2017 Journal Article, 2017

A. Smith, C.R. Breatnach, A.T. James, O. Franklin, A. El-Khuffash, Incidental Findings on Routine Targeted Neonatal Echocardiography performed in Preterm Infants less than 29 weeks gestation. , Congress of joint European Neonatal Society, Venice, Italy 2017 , Venice, Italy , 2017 Oral Presentation, 2017

CR. Breatnach, N Bussman, A. Smith, PT. Levy, N. McCallion, O. Franklin, A. EL-Khuffash , Myocardial Deformation and Rotational Mechanics in Infants with Down Syndrome in the Early Neonatal Period. , Congress of Joint European Neonatal Societies, Venice 2017, 2017 Oral Presentation, 2017

C.R. Breatnach, A.T. James, F. Malone, N. McCallion, O. Franklin, A. EL-Khuffash ., The use of Speckle Tracking Echocardiography to assess Myocardial Performance in Monochorionic Diamniotic Twins with and without Twin to Twin Transfusion Syndrome. , 1. Congress of joint European Neonatal Society, Venice, Italy 2017 , Venice, Itally, 2017 Oral Presentation, 2017

Breatnach CR, Levy PT, Franklin O, El-Khuffash A, Strain Rate and Its Positive Force-Frequency Relationship: Further Evidence from a Premature Infant Cohort., Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2017 Journal Article, 2017

Breatnach CR, El-Khuffash A, James A, McCallion N, Franklin O, Serial measures of cardiac performance using tissue Doppler imaging velocity in preterm infants <29weeks gestations., Early human development, 2017 Journal Article, 2017

CR. Breatnach, N Bussman, A. Smith, PT. Levy, N. McCallion, O. Franklin, A. EL-Khuffash , Myocardial Deformation and Rotational Mechanics in Infants with Down Syndrome in the Early Neonatal Period, British Congenital Cardiac Association London 2017, London , 2017 Oral Presentation, 2017

Lynch A, Ng L, Lawlor T, Lavelle M, Franklin O. , Neonatal Congenital Heart Disease:Modes of Presentation and Prenatal Detection over a 5 Year Period in Ireland, Irish American Paediatric Meeting, Washington US September 2017., Washington US , 2017 Oral Presentation, 2017

CR. Breatnach, C. Monteith, L. McSweeney, EC. Tully, FD. Malone, E. Kent, A. Doherty, O. Franklin, A. EL-Khuffash, The Impact of Maternal Gestational Hypertension on Left and Right Myocardial Performance in the Neonatal Population, Paediatric Academic Societies meeting, San Francisco , 2017 Oral Presentation, 2017

T Martin, A Smith, C Breatnach, E Kent, M Boyle, O Franklin, A EL-Khuffash. , Experience of infants born with a diagnosis of down syndrome in a tertiary neonatal centre: burden of disease and length of hospital stay. Congress of Joint European Neonatal Societies, Congress of Joint European Neonatal Societies, Venice, Italy, 2017 Oral Presentation, 2017

Martin T, Smith A, Breatnach CR, Kent E, Shanahan I, Boyle M, Levy PT, Franklin O, El-Khuffash A, Infants Born with Down Syndrome: Burden of Disease in the Early Neonatal Period., The Journal of pediatrics, 2017 Journal Article, 2017

CR Breatnach, C Monteith, L McSweeney, EC Tully, FD Malone, E Kent, A Doherty, O Franklin, A EL-Khuffash , The Impact of Maternal Gestation Hypertension and Antihypertensive Use on Neonatal Myocardial Performance. , Paediatric Academic Societies meeting, ., San Francisco , 2017 Oral Presentation, 2017

P Levy, C Brennan, M Patel, S Choudhry, AA Sanchez, A EL-Khuffash, C Breatnach, O Franklin, A Hamvas, G Singh. , Emerging quantitative echocardiographic markers of pulmonary vasculae disease and right ventricular dysfunction in extreme preterm infants with late pulmonary hypertension. , Congress of Joint European Neonatal Societies, , Venice, Italy. October 31st - November 4th, 2017, 2017 Oral Presentation, 2017

CR. Breatnach, AT. James, FD. Malone, N. McCallion, O. Franklin, A. El-Khuffash. , The Use of Speckle Tracking Echocardiography to Assess Myocardial Performance in Monochorionic Diamniotic Twins with and without Twin to Twin Transfusion Syndrome, Paediatric Academic Societies meeting, ., San Francisco , 2017 Oral Presentation, 2017

Breatnach CR, Franklin O, James AT, McCallion N, El-Khuffash A, The impact of a hyperdynamic left ventricle on right ventricular function measurements in preterm infants with a patent ductus arteriosus., Archives of disease in childhood. Fetal and neonatal edition, 2017 Journal Article, 2017

C.R. Breatnach, A.T. James, F. Malone, N. McCallion, O. Franklin, A. EL-Khuffash, Speckle Tracking Echocardiography to assess Myocardial Performance in Monochorionic Diamniotic Twins with and without Twin to Twin Transfusion Syndrome. , Congress of joint European Neonatal Society, Venice, Italy, 2017 Oral Presentation, 2017

CR Breatnach, C Monteith, L McSweeney, EC Tully, FD Malone, E Kent, A Doherty, O Franklin, A EL-Khuffash , The Impact of Maternal Gestation Hypertension and Antihypertensive Use on Neonatal Myocardial Performance. , British Congenital Cardiac Association London 2017, London 2017, 2017 Oral Presentation, 2017

Smith A, Breatnach CR, James AT, Franklin O, El-Khuffash A, Incidental Findings on Routine Targeted Neonatal Echocardiography Performed in Preterm Neonates Younger Than 29 Weeks' Gestation., Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2017 Journal Article, 2017

Levy PT, El-Khuffash A, Patel MD, Breatnach CR, James AT, Sanchez AA, Abuchabe C, Rogal SR, Holland MR, McNamara PJ, Jain A, Franklin O, Mertens L, Singh GK, Maturational Patterns of Systolic Ventricular Deformation Mechanics by Two-Dimensional Speckle-Tracking Echocardiography in Preterm Infants over the First Year of Age., Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2017 Journal Article, 2017

Breatnach CR, Monteith C, McSweeney L, Tully EC, Malone FD, Kent E, Doherty A, Franklin O, El-Khuffash A, The Impact of Maternal Gestational Hypertension and the Use of Anti-Hypertensives on Neonatal Myocardial Performance., Neonatology, 2017 Journal Article, 2017

Breatnach CR, Forman E, Foran A, Monteith C, McSweeney L, Malone F, McCallion N, Franklin O, El-Khuffash A, Left ventricular rotational mechanics in infants with hypoxic ischemic encephalopathy and preterm infants at 36 weeks postmenstrual age: A comparison with healthy term controls., Echocardiography (Mount Kisco, N.Y.), 2016 Journal Article, 2016

Breatnach CR, Franklin O, McCallion N, El-Khuffash A, The Effect of a Significant Patent Ductus Arteriosus on Doppler Flow Patterns of Preductal Vessels: An Assessment of the Brachiocephalic Artery., The Journal of pediatrics, 2016 Journal Article, 2016

Breatnach CR, Levy PT, James AT, Franklin O, El-Khuffash A, Novel Echocardiography Methods in the Functional Assessment of the Newborn Heart., Neonatology, 2016 Journal Article, 2016

O'Riordan AM, McGrath N, Sharif F, Murphy NP, Franklin O, Lynch SA, O'Grady MJ, Expanding the clinical spectrum of chromosome 15q26 terminal deletions associated with IGF-1 resistance., European journal of pediatrics, 2016 Journal Article, 2016

N. Walsh , CR. Breatnach , A. EL-Khuffash, O. Franklin , D. Corcoran, Is routine echo warranted in infants admitted with transient tachypnoea of the new born and a prolonged hospital stay, EAPS, Geneva, Switzerland, EAPS, Geneva, Switzerland, 2016 Oral Presentation, 2016

Corcoran S, Briggs K, O' Connor H, Mullers S, Monteith C, Donnelly J, Dicker P, Franklin O, Malone FD, Breathnach FM, Prenatal detection of major congenital heart disease - optimising resources to improve outcomes., European journal of obstetrics, gynecology, and reproductive biology, 2016 Journal Article, 2016

CR. Breatnach, O. Franklin, N. McCallion, A. EL-Khuffash, The Effect of a Significant Patent Ductus Arteriosus on Doppler Flow Patterns of Pre-ductal Vessels: An assessment of the Brachiocephalic Artery, European Academy of Paediatric Societies, Geneva, Switerland, Geneva, Switerland, 2016 Oral Presentation, 2016

CR. Breatnach; E. Forman; A. Foran; C. Monteith; L. McSweeney; FD. Malone; N. McCallion; O. Franklin; A. EL-Khuffash, Left Ventricular Rotational Mechanics in Infants with Hypoxic Ischaemic Encephalopathy and Preterm Infants at 36 Weeks Post Menstrual Age: a Comparison with Healthy Term Controls, European Academy of Paediatric Societies, Geneva, Switerland, Geneva, Switerland, 2016 Oral Presentation, 2016

C. Breatnach , E. Forman , A. Foran , C. Monteith , L. Mc Sweeney , F. Malone , N. McCallion , O. Franklin, A. EL-Khuffash, Left ventricular rotational mechanics in infants with HIE and preterm infants at 36 weeks post menstrual age: a comparison with healthy term controls. , EAPS, Geneva, Switzerland , Geneva, Switzerland , 2016 Oral Presentation, 2016

CR. Breatnach, O. Franklin, AT. James, N. McCallion, A. EL Khuffash, The Impact of a Hyperdynamic Left Ventricle on Right Ventricular Function Measurements in Preterm Infants with a Patent Ductus Arteriosus, European Academy of Paediatric Societies, Geneva, Switerland, Geneva, Switerland, 2016 Oral Presentation, 2016

Letshwiti JB, Semberova J, Pichova K, Dempsey EM, Franklin OM, Miletin J, A conservative treatment of patent ductus arteriosus in very low birth weight infants., Early human development, 2016 Journal Article, 2016

James AT, Corcoran JD, Hayes B, Franklin O, El-Khuffash A, The effect of antenatal magnesium sulfate on left ventricular afterload and myocardial function measured using deformation and rotational mechanics imaging., Journal of perinatology : official journal of the California Perinatal Association, 2015 Journal Article, 2015

El-Khuffash A, James AT, Corcoran JD, Dicker P, Franklin O, Elsayed YN, Ting JY, Sehgal A, Malikiwi A, Harabor A, Soraisham AS, McNamara PJ, A Patent Ductus Arteriosus Severity Score Predicts Chronic Lung Disease or Death before Discharge., The Journal of pediatrics, 2015 Journal Article, 2015

20. Adam T. James, John D. Corcoran, Patrick McNamara, Orla Franklin, Afif El-Khuffash, The Effect of Milrinone on Right and Left Ventricular Function When Used As a Rescue Therapy for Term Infants With Pulmonary Hypertension, Paediatric Academic Society Meeting. San Diego California, , San Diego California, , 2015 Oral Presentation, 2015

James AT, Corcoran D, Jain A, McNamara PJ, Mertens L, Franklin O, EL-Khuffash A, Longitudinal Assessment of Left and Right Myocardial Function in Preterm Infants Using Strain and Strain-rate Imaging , 1st Congress of Joint European Neonatal Society, Budapest, Hungary, 2015 Oral Presentation, 2015

James AT, Corcoran JD, Franklin O, EL-Khuffash A , Global Right Ventricular Fractional Area Change is a Surrogate Marker for Systemic Blood Flow in Preterm Infants, European Society of Paediatrics Research, Budapest, Hungary, Budapest, Hungary, 2015 Oral Presentation, 2015

James A,T, Cleary A, Semberova J, Franklin O, Militen J, El-Khuffash A, Late Medical Therapy of Patent Ductus Arteriorsus using Intravenous Paracetamol, Paediatric Academic Society Meeting , San Diego , USA, 2015 Oral Presentation, 2015

A EL-Khuffash, M.D. Patel , AT James, PJ McNamara, A Jain, O Franklin, A Mathur, C Lee, A Hamvas, GK Singh, L Mertens, PT Levy, Assessment of pulmonary hemodynamic function in preterm infants: Maturational patterns of pulmonary artery acceleration time, European Society of Paediatrics Research, Budapest, Hungary, Budapest, Hungary, 2015 Oral Presentation, 2015

James A, Corcoran JD, Mertens L, Franklin O, El-Khuffash A, Left Ventricular Rotational Mechanics in Preterm Infants Less Than 29 Weeks' Gestation over the First Week after Birth., Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2015 Journal Article, 2015

James AT, Corcoran JD, Franklin O, Mertens L, EL-Khuffash A, Longitudinal Assessment of Myocardial strain and strain rate and the effect of chronic lung disease in Preterm infants less than 29 weeks gestation, European Society of Paediatrics Research, Budapest, Hungary, Budapest, Hungary, 2015 Oral Presentation, 2015

EL-Khuffash A, James AT , Corcoran JD , Dicker P, Franklin O, Elsayed YN, Ting J, Sehgal A, Malikawi A , Harabor A , Soraisham AS , McNamara PJ, A Patent Ductus Arteriosus Severity Score Incorporating Markers of Haemodynamic Significance and Left Ventricle Diastolic Function Predicts Chronic Lung Disease, European Society of Paediatrics Research, Budapest, Hungary, Budapest, Hungary, 2015 Oral Presentation, 2015

EL-Khuffash A, James AT, Cleary A, Semberova J, Franklin O, Miletin J, Late medical therapy of patent ductus arteriosus using intravenous paracetamol., Archives of disease in childhood. Fetal and neonatal edition, 2015 Journal Article, 2015

James AT, Corcoran JD, Franklin O, El-Khuffash AF, Clinical utility of right ventricular fractional area change in preterm infants., Early human development, 2015 Journal Article, 2015

James AT, Corcoran JD, Breatnach CR, Franklin O, Mertens L, El-Khuffash A, Longitudinal Assessment of Left and Right Myocardial Function in Preterm Infants Using Strain and Strain Rate Imaging., Neonatology, 2015 Journal Article, 2015

Breatnach CR, Flanagan F, James A, Corcoran JD, Franklin O, El-Khuffash A, The Use of Inhaled Nitric Oxide in a Tertiary Neonatal Intensive Care Unit., Irish medical journal, 2015 Journal Article, 2015

James AT, Corcoran JD, McNamara PJ, Franklin O, El-Khuffash AF, The effect of milrinone on right and left ventricular function when used as a rescue therapy for term infants with pulmonary hypertension., Cardiology in the young, 2015 Journal Article, 2015

A. Khuffash; MD. Patel; AT. James; CR. Breatnach; A. Sanchez; PJ. McNamara; A. Jain; O. Franklin; A. Hamvas; GK. Singh; L. Mertens; PT. Levy, Maturational Patterns of Ventricular Deformation by Speckle Tracking Echocardiography in Preterm Infants over the First Week of Age, European Academy of Paediatric Societies, Geneva, Switerland, , Geneva, Switerland, , 2015 Oral Presentation, 2015

James AT, Corcoran JD, Hayes B, Franklin O, El-Khuffash A, The Effect of Antenatal Magnesium Sulphate on Left Ventricular Afterload and Myocardial Function Measured using Deformation and Rotational Mechanics Imaging, 1st Congress of Joint European Neonatal Society, Budapest, Hungary, Budapest, Hungary, 2015 Oral Presentation, 2015

Walsh CA, MacTiernan A, Farrell S, Mulcahy C, McMahon CJ, Franklin O, Coleman D, Mahony R, Higgins S, Carroll S, McParland P, McAuliffe FM, Mode of delivery in pregnancies complicated by major fetal congenital heart disease: a retrospective cohort study., Journal of perinatology : official journal of the California Perinatal Association, 2014 Journal Article, 2014

James AT, Corcoran JD, Franklin O, Mertens L, El-Khuffash A, Assessment of Longitudinal Changes in Torsion in Preterm Infants Less than 29 Weeks Gestation, American Society of Echocardiography. Portland, OR, Portland, Oregon, 2014 Oral Presentation, 2014

Adam James, David Corcoran, Amish Jain, Luc Mertens, Patrick McNamara, Orla Franklin and Afif El-Khuffash, Assessment of Myocardial performance using novel Echocardiography markers in infants less than 28 weeks gestation and the impact of the transitional circulation, Paediatric Academic Societies meeting, ., Vancouver BC, 2014 Oral Presentation, 2014

James AT, Corcoran JD, Franklin O, El-Khuffash AF, Clinical Utility of Right Ventricular Fractional Area Change in Preterm Infants, 1st Congress of Joint European Neonatal Society, Budapest, Hungary, Budapest, Hungary, 2014 Oral Presentation, 2014

Saleemi MS, El-Khuffash A, Franklin O, Corcoran JD, Serial changes in myocardial function in preterm infants over a four week period: the effect of gestational age at birth., Early human development, 2014 Journal Article, 2014

James AT, Corcoran JD, Franklin O, Mertens L, El-Khuffash A., , Assessment of Longitudinal Changes in Torsion in Preterm Infants Less than 29 Weeks Gestation, American Society of Echocardiography, Portland, OR, 2014 Oral Presentation, 2014

Adam James, David Corcoran, Amish Jain, Luc Mertens, Patrick McNamara, Orla Franklin and Afif El-Khuffash, Reliability of myocardial performance assessment in preterm infants using Strain and Strain rate: A comparison between left ventricular, septal and right ventricular walls. , Paediatric Academic Societies meeting, ., Vancouver BC, 2014 Oral Presentation, 2014

James AT, Bee C, Corcoran JD, McNamara PJ, Franklin O, El-Khuffash AF, Treatment of premature infants with pulmonary hypertension and right ventricular dysfunction with milrinone: a case series., Journal of perinatology : official journal of the California Perinatal Association, 2014 Journal Article, 2014

Simmonds J, Murchan H, James A, Crispino G, O'Brien J, Crumlish K, Franklin O, Fenton M, Burch M, McMahon CJ, Outcome of shared care for pediatric cardiac transplantation between two nations with different health care systems., The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2014 Journal Article, 2014

Eleanor Molloy, Congenital Diaphragmatic Hernia - Prenatal to Childhood Management and Outcomes, 2012 Journal Article, 2012

Armstrong K, Franklin O, Molloy EJ, Sweetman D, Cardiovascular dysfunction in infants with neonatal encephalopathy., 2012 Journal Article, 2012

MS Saleemi, O Franklin, Normative values for Tissue Doppler Imaging (TDI) velocities in preterm infants, ESPR-52nd annual meeting of the European Society for Paediatric Research-New Castle, UK, New Castle, UK, 2011 Oral Presentation, 2011

MS Saleemi, JD Corcoran, O Franklin, Myocardial contractility by Tissue Doppler Imaging (TDI) in healthy term versus sick term neonates, ESPR-52nd Annual meeting of the European Society for Paediatric Research-New Castle, UK, New Castle, UK, 2011 Oral Presentation, 2011

MS. Saleemi, O Franklin, JD Corcoran, The biochemical and echocardiographic effects of anaemia of prematurity and transfusion on cardiac functions in the VLBW infant, The 3rd Congress of the European Academy of Paediatric Societies (EAPS) , Copenhagen, Denmark , 2010 Oral Presentation, 2010

Smith S, Ng, L, Lavelle M, Molloy E, Franklin O, Neonatal Cardiac infants: Clinical status from birth to arrival at the national paediatric centre, European Academy Paediatric Societies , European Academy Paediatric Societies , 2010 Oral Presentation, 2010

Khambadkone S. Boujemline E, Derrick G, Franklin O, Cullen S, Deanfield J, Bonhoeffer P, Percutaneous pulmonary valve implantation:Early and Medium term results, American Heart Association, Florida USA, 2003 Oral Presentation, 2003

Khambadkone S. Boujemline E, Derrick G, Franklin O, Cullen S, Deanfield J, Bonhoeffer P, Percutaneous pulmonary valve implantation:Early and Medium term results, American Heart Association, Florida USA, 2003 Oral Presentation, 2003

Inwald DP, Franklin O, Peters MJ, Goldman AJ, Burch M, Enterovirus myocarditis as a cause of neonatal collapse, Royal College of Paediatric Spring Meeting , UK, 2003 Oral Presentation, 2003

Khambadkone S. Boujemline E, Derrick G, Franklin O, Cullen S, Deanfield J, Bonhoeffer P, Percutaneous pulmonary valve implantation in humans- Initial Experience, Association European Paediatric Cardiology, Amsterdam, Netherlands, 2003 Oral Presentation, 2003

O Franklin, M Burch, N Manning, K Sleeman, S Gould, N Archer, Prenatal Diagnosis of Coarctation of the Aorta Improves Survival and Reduces Morbidity, Heart 87 (1), 67-69, Heart 87 (1), 67-69, 2002, p67 - 69 Journal Article, 2002

Non-Peer-Reviewed Publications

Orla Franklin, Interventions for the Borderline Ventricles Echo Assessment, PICS- AICS 2020, Istanbul, January 2oth, 2020, Paediatric Interventional Cardiology Society Invited Talk, 2020

Orla Franklin, Challanging outflow tract imaging in fetuses with Congenital Heart Disease, British \medical Ultrasound Annual Summer School, UCD, Dublin, 2017 Invited Talk, 2017

Orla Franklin, Challanging outflow tract imaging in fetuses with Congenital Heart Disease, British \medical Ultrasound Annual Summer School, UCD, Dublin, 2017 Invited Talk, 2017

Orla Franklin, Challenges and Innovations in Prenatal Cardiac Imaging, Irish Perinatal Society Annual Meeting, Royal College of Physicians, 2016 Invited Talk, 2016

Orla Franklin, Dieticians Contribution in the management of Children with Congenital Heart Disease, CHI@Crumlin, Dublin Ireland, 2016, Irish Dieticians Network Invited Talk, 2016

Orla Franklin, Imaging Challenges in Complex Left Heart Obstruction, Inaugural All Ireland CHD Network Meeting , Ballymacscallion, 2016 Invited Talk, 2016

Orla Franklin, Prenatal Therapies for Congenital Heart Disease, Institute of Obstetrics and Gynaecology Annual Meeting October 2015, Royal College of Physicians, 2015 Invited Talk, 2015

Orla Franklin, Diagnosis and Management : Presentation of Children with Congenital Heart Disease, Paediatric Intensive Care Society - World Congress Meeting, Dublin - National Conference Centre, November, 2014 Invited Talk, 2014

Orla Franklin, Diagnosis and Management of Infants with Congenital Heart Disease, Inherited Birth Defects - National Genetic Meetng, Mater Education Centre, 2014 Invited Talk, 2014

Orla Franklin, Congenital Heart Disease and Extracardiac Life Support, National ECLS Meeting, Mater Education Centre, 2013 Invited Talk, 2013

Orla Franklin, Down Syndrome - Prenatal diagnosis of associated Congenital Heart Disease, Fetoscopy, Dublin Ireland, September 2011, 2011, Fetsocopy Group Invited Talk, 2011

O Franklin, M Burch, N Manning, K Sleeman, S Gould, N Archer, Prenatal Diagnosis of Coarctation of the Aorta Improves Survival and Reduces Morbidity, Heart 87 (1), 67-69, Heart 87 (1), 67-69, 2002, p67 - 69 Journal Article, 2002

Research Expertise

Projects

  • Title
    • A Randomised Controlled Trial of Early Targeted Patent Ductus Arteriosus Treatment Using a Risk Based Severity Score
  • Summary
    • Patent arterial duct is associated with an increased risk of extra-cardiac morbidity such as IVH, NEC, CLD and poor neurodevelopmental outcome. This study applies a comprehensive risk core to quantify PDA significance and where the score value indicated increased risk of developing CLD/ death the patient is randomized to either treatment with ibuprofen or placebo. Presence of a ductus and detailed functional assessment of its impact on myocardial performance is undertaken. The primary outcome of the study is CLD diagnosed at 36 weeks or death before discharge.
  • Funding Agency
    • National Children's Research Centre
  • Date From
    • July 2017
  • Date To
    • July 2020
  • Title
    • Assessment of Cardiac Function in Preterm and Term Infants with Twin to Twin Transfusion Syndrome Using Novel Echocardiography Techniques
  • Summary
    • Characterisation of myocardial performance in infants with disease states such as twin-to-twin transfusion syndrome, intra-uterine growth retardation and congenital diaphragmatic hernia usng novel functional assessment of myocardial performance in preterm and early term infants. Cardiac function was assessed with new techniques such as tissue dopper imaging, myocardial strain performance throughout the cardiac cycle.
  • Funding Agency
    • National Children's Research Centre
  • Date From
    • July2017
  • Date To
    • December 2019
  • Title
    • Longitudinal Assessment of Cardiac Function in Infants with Downs Syndrome Using Novel Echocardiography Techniques
  • Summary
    • Thisapplies echocardiographic functional assessment tools for both right and left ventricular myocardial performance to babies with Down Syndrome tracking changes in measured parameters over the first days and months of life.
  • Funding Agency
    • National Children's Research Centre
  • Date From
    • October 2017
  • Date To
    • Ongoing
  • Title
    • Post-Operative Myocardial Performance and Pulmonary Hypertension in Infants with Down Syndrome: The Role of Inflammation.
  • Summary
    • This is a study of indices of right and left ventricular function in babies with Down Syndrome who are admitted for surgical repair of congenital heart disease associated with a systemic to pulmonary shunt. Measurements of pro-BNP, troponin levels, pro-inflammatory cytokines and chemokines measurements will further inform us as to the inflammatory response to and functional myocardial impact of cardiothoracic surgery.
  • Funding Agency
    • National Children's Research Centre
  • Date From
    • July 2018
  • Date To
    • July 2020
  • Title
    • A Randomised Controlled Trial of Early Targeted Patent Ductus Arteriosus Treatment Using a Risk Based Severity Score
  • Summary
    • Patent arterial duct is associated with an increased risk of extra-cardiac morbidity such as IVH, NEC, CLD and poor neurodevelopmental outcome. This study applies a comprehensive risk core to quantify PDA significance and where the score value indicated increased risk of developing CLD/ death the patient is randomized to either treatment with ibuprofen or placebo. Presence of a ductus and detailed functional assessment of its impact on myocardial performance is undertaken. The primary outcome of the study is CLD diagnosed at 36 weeks or death before discharge.
  • Funding Agency
    • Temple Street Children's Hospital Foundation
  • Date From
    • September 2016
  • Date To
    • July 2020
  • Title
    • Can sonographic assessment of pulmonary vascular reactivity following maternal hyperoxygenation therapy predict neonatal outcome in fetuses at risk of pulmonary hypoplasia?
  • Summary
    • This study seeks to establish if sonographic assessment of pulmonary vascular reactivity following maternal hyperoxygenation therapy predict neonatal outcome in fetuses at risk of pulmonary hypertension (PHN)? This occurs when there is a failure of the normal circulatory transition in the early newborn period. This study seeks to establish if changes in the fetal pulmonary circulation in response to prenatal maternal oxygen administration can predict postnatal respiratory morbidity in infants with conditions such as IUGR and premature rupture of membranes as well as congenital cardiac lesions with a systemic to pulmonary shunt who are at risk of postnatal PHN
  • Funding Agency
    • The Rotunda Hospital Foundation
  • Date From
    • October 2016
  • Date To
    • June 2020
  • Title
    • Newborn Heart Study - Novel Echocardiographic and Biomarker Measurements in Health and Disease
  • Summary
    • This study investigated neonatal myocardial dysfunction and its potential for negatively impacting on survival outcomes in preterm and term infants. This study investigated how serial ECHO assessment of myocardial functional parameters such as Tissue Doppler imaging and speckle tracking of the neonatal myocardium in the NICU would improve outcomes in preterm infants by allowing early therapeutic intervention.
  • Funding Agency
    • National Children's Research Centre
  • Date From
    • July 2012
  • Date To
    • July 2014
  • Title
    • Longitudinal Assessment of Cardiac Function in Infants with Downs Syndrome Using Novel Echocardiography Techniques
  • Summary
    • This study will apply echocardiographic functional assessment tools for both right and left ventricular myocardial performance to babies with Down Syndrome tracking changes in measured parameters over the first days and months of life.
  • Funding Agency
    • Health Research Board / National Children's Hospital Foundation
  • Date From
    • June 2017
  • Date To
    • Ongoing

Keywords

DOWN-SYNDROME; NEONATE; PATENT DUCTUS-ARTERIOSUS; PRETERM INFANTS

Recognition

Representations

Irish Representative on the National Fetal Cardiology Group UK & Ireland 2016

Irish Representative on the British Paediatric Surveillance (BPSU) Kawasaki Group. This resulted in a comprehensive assessment of the clinical course, treatment and long-term outcomes of Kawasaki Disease in children in the UK and Ireland. The results were published in Archives of Disease in Childhood in 2019 under the title 'Kawasaki disease: a prospective population survey in the UK and Ireland from 2013 to 2015. Tulloh et al 2019 Jul;104(7):640-646 January 2014

External Professional Advisor for the Parlimentary and Health Service Ombudman of the United Kingdom 2008

External Professional Advisor for the Parlimentary and Health Service Ombudman of the United Kingdom 2018

Neonatal and Paediatric Specialist Retrieval Expert Group - This group agreed the workforce model for transport and retrieval of neonates and children, created the Job Descriptions for the National Leads in Neonatal and Paediatric retrieval and defined the training requirements and competencies for all staff involved in neontatal and paediatric retrieval. April 2018

Vice-president of the Irish Hospital Consultants Association 2017- 2019 2017-2019

Board Member of the Irish Hospital Consultants Associaition 2016-2019 February 2016-June 2019

I was the medical lead/senior author of the nationally protocol detailing the dosage and IV smart pump administration of Prostin to neonates with cyanotic congenital heart disease. The Prostin administration document is now used nationally in all paediatric centres and for all retrivals of infants with congenital heart disease. This policy has been co-opted by the Irish Paediatric Critical Care Network March 2011

I was the medical lead on the Standard Operating Procedure for the Prescribing and Administration of Amiodarone by IV infusion outside of the PICU in Our Lady's Children's Hospital Crumlin 2011 April 2011

I am the medical lead on the Standard Operating Procedure for the use of portable T60 pumps in Our Lady's Children's Hospital Crumlin, these pumps allow children who are chronically dependent of the administration of IV infusions to maintain cardiovascular health while awaiting heart transplant to spend some time outside and offsite. The use of these pumps is a novel development in the management of such children in the British Isles . This national policy was established in 2018 September 2018

I was the medical lead and senior author of the Standard Operating Procedure for the IV administration of Heparin outside of the PICU in Children's Health Ireland@ Crumlin in 2014 June 2014

Awards and Honours

Irish Paediatrcian of the Year. Proposed and Supported by Parents of Patients Maternity and Infant Awards 2012 November 2012

Undergraduate Scholarship UCC , Academic Achievement June 1991

Undergraduate Scholarship UCC , Academic Achievement June 1987

Awards - Service Development - Finalist Irish Healthcare Centre Awards Specialist Care Centre of the Year - Children's Heart Centre 7th March 2014

Finalist Irish Healthcare Centre Awards Building Project of the Year RKD Architects - Children's Heart Centre 7th March 2014

Tissue velocity imaging quantifies early changes in pre-term myocardium. Irish Paediatric Association 2020 - 1st Prize Oral Presentation December 2020

Ireland- Imaging Modalities Employed in Delineation of Sinus Venous Defects and Outcome Over Last Decade, Best poster award - All Ireland Children Cardiac Network conference November 2019

A Patent Ductus Arteriosus Severity Score Incorporating Markers of Haemodynamic Significant and Left Ventricular Diastolic Function Predicts Chronic Lung Disease. Irish Neonatal Research Symposium First Prize: Dublin. November 2013

A Patent Ductus Arteriosus Severity Score Incorporating Markers of Haemodynamic Significant and Left Ventricular Diastolic Function Predicts Chronic Lung Disease. Irish Paediatric Association Best Researcher Award . May 2015

Left Ventricular Rotational Mechanics in Infants with Hypoxic Ischaemic Encephalopathy and Preterm Infants at 36 Weeks Post Menstrual Age: a Comparison with Healthy Term Controls. Best Presentation Award, Irish Neonatal Research Symposium 2016. November 2016

The Use of Speckle Tracking Echocardiography to Assess Myocardial Performance in Monochorionic Diamniotic Twins with and without Twin to Twin Transfusion Syndrome. Paediatric Academic Societies Travel Awards Program for Young Investigator's. $500 put this in

Maturational Patterns of Ventricular Deformation by Speckle Tracking Echocardiography in Preterm Infants over the First Week of Age. Rotunda Hospital Research Day, Award 300 2016

The Impact of a Hyperdynamic Left Ventricle on Right Ventricular Function Measurements in Preterm Infants with a Patent Ductus Arteriosus, Best Researcher Award, Joint Irish Paediatric Association(IPA)/Irish & American Paediatric Society Meeting-Award 1000 euro. 2016

The Effect of a Significant Patent Ductus Arteriosus on Doppler Flow Patterns of Pre-ductal Vessels: An assessment of the Brachiocephalic Artery, Runner up in Presidential poster walk, Joint Irish Paediatric Association(IPA)/Irish & American Paediatric Society Meeting 2016

Neonatal Congenital Heart Disease: Modes of Presentation and Prenatal Detection over a 5 year Period in Ireland. Irish American Paediatric Society Seattle - Oral Presentation- Travel grant Awarded. September 2017

Incidental findings on routine targeted neonatal echocardiography performed in preterm infants less than 29 weeks gestation. 8th Irish Neonatal research symposium 1st prize presentation 2017

Can Sonographic Assessment of Pulmonary Vascular reactivity following Maternal hyperoxygenation therapy predict neonatal outcome in fetuses at risk of pulmonary hypertension-Irish Perinatal Society Kilkenny - Best Oral Presentation November 2017

The Use of Speckle Tracking Echocardiography to Assess Myocardial Performance in Monochorionic Diamniotic Twins with and without Twin to Twin Transfusion Syndrome -BCCA London November 2017 Runner up Prize Oral Presentation session November 2017

The Impact of Maternal Gestation Hypertension and Antihypertensive Use on Neonatal Myocardial Performance. BCCA meeting London -1st place poster award November 2017

Prenatal Detection and Modes of Presentation of Neonatal Congential Heart Disease: a 5 year progress review. 8th OLCHC Research and Audit Day - Poster Award May 2018

The Impact of Blood Transfusion on the Haemodynamics of Preterm Infants with and Without a Patent Ductus Arteriosus. European Society for Paediatric Research (ESPR) Young Investigator START-UP Award. Grant value €7,000 September 2019

Special Merit Award Oral Presentation, The 10th Irish Neonatal Research Symposium: Comparison of Left Ventricular Rotational Mechanics Between Term and Extremely Premature Infants Over the First Week of Age 2019

Best Oral Presentation (Neonatology Session), Irish Paediatric Association (IPA) Annual Meeting: Comparison of Left Ventricular Rotational Mechanics Between Term and Extremely Premature Infants Over the First Week of Age 2019

Health Research board (HRB) Ones to Watch prize Winner 2019

Memberships

Fellowship of the Royal College of Paediatricians and Child Health. I was a founding member of the College in 1996 1996 – Present

Fellowship of the Royal College of Paediatricans of Ireland- I became a member of the Royal College of Physicians in 1995 and a fellow of the College in May 2020 June 1995 – Present

British Congenital Cardiac Association January 2000 – Present

Association of European Paediatric and Congenital Cardiology January 2021 – Present

Irish Representative on the National Fetal Cardiology Group UK and Ireland 2016 – Present

Neonatal ECHO functional Assessment Imaging Group Founder member in collaboration with Prof Afif ElKhuffash Rotunda One MD and two PhD student to the successful completion of their theses. A further student has submitted an MD theses currently undergoing revisions and an additional PhD student is writing up their thesis. This groups currently has a output of peer reviewed publications January 2013 – Present

DISCO - Down Syndrome -Down Syndrome Inflammation and Clinical Uutcomes Research Group Affiliated to Trinity Research in Childhood 2018 – Present