Skip to main content

Trinity College Dublin, The University of Dublin

Trinity Menu Trinity Search



You are here Staff

Dr. Achilleas Floudas
Senior Research Fellow, Clinical Medicine TBSI

Biography

I obtained my Ptyxio (BSc+ Diploma) in molecular Biology by the University of Crete, Greece in 2010. In the same year I received a PhD studentship by the Institute of Molecular Medicine of Newcastle University, UK. During this time I worked on the role of B cells in the liver autoimmune disease Primary Biliary Cirrhosis (PBC). I first joined TCD in 2014. Currently I am a HRB Senior Research Fellow at the Molecular Rheumatology group and I am interested in the identification and functional characterisation of immune and stromal cell crosstalk in the inflamed joint in Rheumatic diseases with the ultimate goal of identifying novel therapeutic targets.

I have been awarded an Irish Research Council postdoctoral fellowship (2015), the postdoctoral Research Innovation award (2020) by the charity CARD and more recently I was elected at the rank of Senior Research Fellow (2021) by TCD and was an awardee of the TCD Research Boost program (2021).

I am a strong advocate of patient partnership in research with extensive involvement in patient and public engagement, patient partners of my current research and publications in popular media outlets.

Publications and Further Research Outputs

Peer-Reviewed Publications

Clare Cunningham1,2, Sarah Wade1,2, Carl Orr2, Achilleas Floudas1,2, Trudy McGarry1, Siobhan Wade, AChilleas Floudas, Sian Cregan, Ursula Fearon, Douglas J Veale., Serum miRNAs signature in Rheumatoid Arthritis and 'at risk individuals', Frontiers in Immunology, Mar, fimmu.2021.633, 2021 Journal Article, 2021

Floudas A, Canavan M, McGarry T, Mullan R, Nagpal S, Veale DJ, Fearon U., ACPA Status Correlates with Differential Immune Profile in Patients with Rheumatoid Arthritis, Cells, ;10(3):, (64), 2021, pdoi: 10.33- Journal Article, 2021

A Floudas, N Neto, C Orr , M Canavan, P Gallagher , C Hurson , MG Monaghan, S Nagpar, R Mullan, DJ Veale, U Fearon, Loss of balance between protective and pro-inflammatory synovial tissue T-cell polyfunctionality predates clinical onset of Rheumatoid Arthritis. , Annals of the Rheumatic Diseases, 2021 Journal Article, 2021 URL

Murray K, Floudas A, Murray C, Fabre A, Crown J, Fearon U, Veale D, First use of tofacitinib to treat an immune checkpoint inhibitor-induced arthritis., BMJ, Feb 4;14(2):e238851., 2021 Journal Article, 2021

Frontiers in Immunology, Frontiers Media SA, [eds.], 2021 Editorial Board, 2021

A. Floudas*, N. Neto, V. Marzaioli, K. Murray, B. Moran, M.G. Monaghan, C. Low, R.H. Mullan ,N.L. NL, V. Krishna, S. Nagpar, D.J. Veale, U. Fearon. , Pathogenic, glycolytic PD-1+ B cells accumulate in the hypoxic RA joint. JCI insights, 2020 , JCI Insights, 2020 Journal Article, 2020 URL

Marzaioli V, Canavan M, Floudas A, Wade SC, Low C, Veale DJ, Fearon U., Monocyte-Derived Dendritic Cell Differentiation in Inflammatory Arthritis Is Regulated by the JAK/STAT Axis via NADPH Oxidase Regulation., Front Immunol, Jul 7;11:1406., 2020 Journal Article, 2020

Foley, C., Floudas, A., Canavan, M., Biniecka, M., MacDermott, E. J., Veale, D. J., Mullan, R. H., Killeen, O. G., Fearon, U., Increased T Cell Plasticity With Dysregulation of Follicular Helper T, Peripheral Helper T, and Treg Cell Responses in Children With Juvenile Idiopathic Arthritis and Down Syndrome"Associated Arthritis, Arthritis & Rheumatology, 72, (4), 2020, p677-686 Journal Article, 2020 DOI

Floudas A, Neto N, Marzaioli V, Murray K, Moran B, Monaghan MG, Low C, Mullan RH, Rao N, Krishna V, Nagpal S, Veale DJ, Fearon U., Pathogenic, glycolytic PD-1+ B cells accumulate in the hypoxic RA joint., JCI insight, 5, (21), 2020 Journal Article, 2020 DOI

Sean P. Saunders, Achilleas Floudas, Tara Moran, Ciara M. Byrne, Michael D. Rooney, Caoimhe M.R. Fahy, Joan A. Geoghegan, Yoichiro Iwakura, Padraic G. Fallon, Christian Schwartz, Dysregulated skin barrier function in Tmem79 mutant mice promotes IL"17A"dependent spontaneous skin and lung inflammation., Allergy, 2020 Journal Article, 2020

Rheumatology, Oxford Academic, [eds.], 2019 Editorial Board, 2019

Schwartz C, Moran T, Saunders S.P, Kaszlikowska A, Floudas A, Bom J, Nunez G, Iwakura Y, O†Neill L, Irvine A.D, McKenzie A.N.J, Ogg G, Walsh P.T, Demengeot J, Fallon P.G, Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β, Allergy: European Journal of Allergy and Clinical Immunology, 2019, p1-- Journal Article, 2019 TARA - Full Text DOI URL

Floudas, Achilleas, Aviello, Gabriella, Schwartz, Christian, Jeffery, Ian B., O'Toole, Paul W., Fallon, Padraic G., Schistosoma mansoni Worm Infection Regulates the Intestinal Microbiota and Susceptibility to Colitis, Infection and Immunity, 87, (8), 2019 Journal Article, 2019 DOI

Ui Mhaonaigh, A., Coughlan, A. M., Dwivedi, A., Hartnett, J., Cabral, J., Moran, B., Brennan, K., Doyle, S. L., Hughes, K., Lucey, R., Floudas, A., Fearon, U., McGrath, S., Cormican, S., De Bhailis, A., Molloy, E. J., Brady, G., & Little, M. A., Low Density Granulocytes in ANCA Vasculitis Are Heterogenous and Hypo-Responsive to Anti-Myeloperoxidase Antibodies., Frontiers in immunology, 10, (2603), 2019 Journal Article, 2019 DOI TARA - Full Text

Floudas A, Saunders SP, Moran T, Schwartz C, Hams E, Fitzgerald DC, Johnston JA, Ogg GS, McKenzie AN, Walsh PT, Fallon PG., IL-17 receptor a maintains and protects the skin barrier to prevent allergic skin inflammation, Journal Of Immunology, 199, (2), 2017, p707-717 Journal Article, 2017 DOI

Floudas A, Cluxton CD, Fahel J, Khan AR, Saunders SP, Amu S, Alcami A, Fallon PG., Composition of the Schistosoma mansoni worm secretome: Identification of immune modulatory Cyclophilin A., PLoS neglected tropical diseases, 11, (10), 2017, pe0006012 Journal Article, 2017 TARA - Full Text DOI

Schwartz C, Khan AR, Floudas A, Saunders SP, Hams E, Rodewald HR, McKenzie ANJ, Fallon PG., ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control., The Journal of experimental medicine, 214, (9), 2017, p2507-2521 Journal Article, 2017 DOI

Floudas A, Amu S, Fallon PG., New Insights into IL-10 Dependent and IL-10 Independent Mechanisms of Regulatory B Cell Immune Suppression., Journal of clinical immunology, 36 Suppl 1, 2016, p25-33 Journal Article, 2016 DOI

Jopson, Laura, Newton, Julia L, Palmer, Jeremy, Floudas, Achilleas, Isaacs, John, Qian, Jessica, Wilkinson, Jennifer, Trenell, Mike, Blamire, Andrew, Howel, Denise, Jones, David E, RITPBC: B-cell depleting therapy (rituximab) as a treatment for fatigue in primary biliary cirrhosis: study protocol for a randomised controlled trial: Figure 1, BMJ Open, 5, (8), 2015, pe007985 Journal Article, 2015 DOI

Saunders SP, Moran T, Floudas A, Wurlod F, Kaszlikowska A, Salimi M, Quinn EM, Oliphant CJ, Núñez G, McManus R, Hams E, Irvine AD, McKenzie AN, Ogg GS, Fallon PG, Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity., Journal of Allergy and Clinical Immunology, 137, (2), 2015, 482-491 Journal Article, 2015 TARA - Full Text DOI

Khan AR, Hams E, Floudas A, Sparwasser T, Weaver CT, Fallon PG, PD-L1(hi) B cells are critical regulators of humoral immunity., Nature communications, 6, 2015, p5997 Journal Article, 2015 TARA - Full Text DOI

Ciechomska, Marzena, Wilson, Caroline L., Floudas, Achilleas, Hui, Wang, Rowan, Andrew D., van Eden, Willem, Robinson, John H., Knight, Andrew M., Antigen-specific B lymphocytes acquire proteoglycan aggrecan from cartilage extracellular matrix resulting in antigen presentation and CD4+T-cell activation, Immunology, 141, (1), 2014, p70-78 Journal Article, 2014 DOI

Research Expertise

Description

Rheumatic diseases affect up to 60% of the 120-million EU-citizens, at an estimated cost of €240-billion with direct costs of 2% EU-GDP. Inflammatory Arthritis (IA), including Rheumatoid Arthritis(RA) and Psoriatic Arthritis(PsA) cause significant joint destruction, disability, increased mortality and are associated with co-morbidities leading to a severe impact on the productivity and quality of life of over 40.000 people in Ireland. While novel biotherapeutics have improved management of IA, there are no cures. Furthermore it is impossible to predict who will develop severe, erosive disease or who will respond to treatment thus patients are subjected to several rounds of "exploratory" treatments until the right treatment is identified.  Importantly, this results in severe debilitating trauma for the patients. Therefore, I am interested in combining RNAseq and state of the art bioinformatic approaches with novel ex vivo experiments utilizing patient samples in order to identify biomarkers of disease and new therapeutic options for patients with arthritis in an effort to reduce the need for exploratory treatments.

Keywords

ARTIFICIAL INTELLIGENCE; B-CELLS; CD4+ T CELLS; FLOW CYTOMETRIC ANALYSIS; PPI; RHEUMATOID ARTHRITIS; RNAseq

Recognition

Awards and Honours

Elected to the rank of Senior Research Fellow 2021

First Scientific Oral Prize - Awarded by the Irish Society of Rheumatology 2021

Milstein Abstract Award - Cytokines2020 2020

CARD - Postdoctoral fellow research Innovation Award 2020

First Scientific Oral Prize - Awarded by the Irish Society of Rheumatology 2019

11 travel awards from EULAR, EMBO, ACR, EWRR, BSI, WIRM, Milstein 2015-2021

IRC postdoctoral Fellowship 2015

Hellenic Math Society First Prize - Competition Thalis 2001

Memberships

EUMUNET(EULAR network for young Rheumatologists) 2017 – 2021

Cytokine Society 2019

Irish Society of Immunology 2017

Irish Society of Rheumatology 2020 2020

American Association of Immunology 2017 – 2019

British Society of Immunology 2010 – 2015