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Dr. Beatrice Nolan
Clinical Senior Lecturer, Paediatrics

Publications and Further Research Outputs

Peer-Reviewed Publications

Christoph Königs, Margareth C Ozelo, Amy Dunn, Roshni Kulkarni, Beatrice Nolan, Simon A Brown, Dr, Michele Schiavulli, Sriya Gunawardena, Sutirtha Mukhopadhyay, Deepthi Jayawardene, Bent Winding, Manuel Carcao, First study of extended half-life rFVIIIFc in previously untreated patients with hemophilia A: PUPs A-LONG final results, Blood, 2022 Journal Article, 2022 DOI

Hassan Eliwan and Murwan Omer and Ellen McKenna and Lynne A. Kelly and Beatrice Nolan and Irene Regan and Eleanor J. Molloy, Protein C Pathway in Paediatric and Neonatal Sepsis, Frontiers in Pediatrics, 9, 2022 Journal Article, 2022 DOI

Swan D., Paran S., Nolan B., Port removal in patients receiving emicizumab prophylaxis: A single centre experience and review of the literature, Haemophilia, 28, (1), 2022, p42 - 45, p42-45 Journal Article, 2022 DOI

Minna K., Anne M., Beatrice N., Rainer K., Susanna R., Correction of haemostasis can be reduced to four days for CVAD implantation in severe haemophilia A patients: Data from the PedNet study group, Haemophilia, 27, (3), 2021, p392 - 397, p392-397 Journal Article, 2021 DOI

Dawn Swan and Sri Paran and Beatrice Nolan, Port removal in patients receiving emicizumab prophylaxis: A single centre experience and review of the literature, Haemophilia, 2021 Journal Article, 2021 DOI

Nolan B., Klukowska A., Shapiro A., Rauch A., Recht M., Ragni M., Curtin J., Gunawardena S., Mukhopadhyay S., Jayawardene D., Winding B., Fischer K., Liesner R., Final results of the PUPs B-LONG study: Evaluating safety and efficacy of rFIXFc in previously untreated patients with hemophilia B, Blood Advances, 5, (13), 2021, p2732 - 2739, p2732-2739 Journal Article, 2021 DOI

Beatrice Nolan and Michael Recht and Pablo Rendo and Aletta Falk and Meredith Foster and Sandra Casiano and Antoine Rauch and Amy D. Shapiro, Prophylaxis with rFIXFc Reduces the Frequency and Delays Time to First Spontaneous Bleed Event in Previously Untreated Patients with Hemophilia B: A Post Hoc Analysis of the PUPs B-LONG Trial, Blood, 138, (Supplement 1), 2021, p498--498 Journal Article, 2021 DOI

Male C., Andersson N.G., Rafowicz A., Liesner R., Kurnik K., Fischer K., Platokouki H., Santagostino E., Chambost H., Nolan B., Konigs C., Kenet G., Ljung R., Van Den Berg H.M., Inhibitor incidence in an unselected cohort of previously untreated patients with severe hemophilia B: A PedNet study, Haematologica, 106, (1), 2021, p123 - 129, p123-129 Journal Article, 2021 DOI

Beatrice Nolan and Michael Recht and Pablo Rendo and Aletta Falk and Meredith Foster and Sandra Casiano and Antoine Rauch and Amy D. Shapiro, Prophylaxis with rFIXFc Reduces the Frequency and Delays Time to First Spontaneous Bleed Event in Previously Untreated Patients with Hemophilia B: A Post Hoc Analysis of the PUPs B-LONG Trial, Blood, 138, (Supplement 1), 2021, p498--498 Journal Article, 2021 DOI

G. Kenet, B. Nolan, J. Oldenburg, J. Motwani, R. D' Oiron, C. Male, H. Chambost, K. Fischer, C. Van Geet, H.M. van den Berg, PedNet Study Group, Emicizumab Treatment in Pediatric Haemophilia A Patients: >1 Year Safety Based on Real-world Data from the PedNet Cohorts, Research and Practice in Thrombosi s and Hemostasis, ISTH 2021, on line, July 2021, 5 ( suppl 1), 2021 Poster, 2021 URL

Hermans C., Mancuso M.E., Nolan B., Pasi K.J., Recombinant factor VIII Fc for the treatment of haemophilia A, European Journal of Haematology, 106, (6), 2021, p745 - 761, p745-761 Journal Article, 2021 DOI

Pasi K.J., Fischer K., Ragni M., Kulkarni R., Ozelo M.C., Mahlangu J., Shapiro A., P'Ng S., Chambost H., Nolan B., Bennett C., Matsushita T., Winding B., Fruebis J., Yuan H., Rudin D., Oldenburg J., Long-term safety and sustained efficacy for up to 5 years of treatment with recombinant factor IX Fc fusion protein in subjects with haemophilia B: Results from the B-YOND extension study, Haemophilia, 26, (6), 2020, pe262 - e271, pe262-e271 Journal Article, 2020 DOI

Christoph Koenigs, Margareth C. Ozelo, Amy Dunn, Roshni Kulkarni, Beatrice Nolan, Simon A. Brown Raina Liesner, Michele Schiavulli, Sriya Gunawardena, Sutirtha Mukhopadhyay, Deepthi Jayawardene, Bent Winding and Manuel Carcao, Final Results of PUPs A-LONG Study: Evaluating Safety and Efficacy of rFVIIIFc in Previously Untreated Patients with Haemophilia A, 62nd ASH Annual Meeting and Exposition, On line, 5-8 Dec 2020, 2020 Oral Presentation, 2020 URL

Male C., Lensing A.W.A., Palumbo J.S., Kumar R., Nurmeev I., Hege K., Bonnet D., Connor P., Hooimeijer H.L., Torres M., Chan A.K.C., Kenet G., Holzhauer S., Santamaria A., Amedro P., Chalmers E., Simioni P., Bhat R.V., Yee D.L., Lvova O., Beyer-Westendorf J., Biss T.T., Martinelli I., Saracco P., Peters M., Kallay K., Gauger C.A., Massicotte M.P., Young G., Pap A.F., Majumder M., Smith W.T., Heubach J.F., Berkowitz S.D., Thelen K., Kubitza D., Crowther M., Prins M.H., Monagle P., Molinari A.C., Nowak Gottl U., Chain J., Robertson J., Thom K., Streif W., Schwarz R., Schmitt K., Grangl G., Van Damme A., Maes P., Labarque V., Petrilli A., Loggeto S., Azeka E., Brandao L., Le D., Sabapathy C., Giordano P., Wu R., Ding J., Huang W., Mao J., Lahteenmaki P., Decramer S., Bernig T., Chada M., Chan G., Kally K., Nolan B., Revel-Vilk S., Tamary H., Levin C., Tormene D., Abbattista M., Artoni A., Ikeyama T., Inuzuka R., Yasukochi S., Morales Soto M., Solis Labastida K.A., Suijker M.H., Bartels M., Tamminga R.Y., Van Ommen C.H., Te Loo D.M., Anjos R., Zubarovskaya L., Popova N., Samochatova E., Belogurova M., Svirin P., Shutova T., Lebedev V., Barbarash O., Koh P.L., Mei J.C., Podracka L., Berrueco R., Fernandez M.F., Frisk T., Grunt S., Rischewski J., Albisetti-Pedroni M., Antmen A., Tokgoz H., Karakas Z., Motwani J., Williams M., Grainger J., Payne J., Richards M., Baird S., Bhatnagar N., Aramburo A., Crary S., Wynn T., Carpenter S., Ahuja S., Goldenberg N., Woods G., Godder K., Scott-Emuakpor A., Roach G., Raffini L., Shah N., Shah S., Thornburg C., Zia A., Berkow R., Rivaroxaban compared with standard anticoagulants for the treatment of acute venous thromboembolism in children: a randomised, controlled, phase 3 trial, The Lancet Haematology, 7, (1), 2020, pe18 - e27, pe18-e27 Journal Article, 2020 DOI

Hermans C., Giangrande P.L.F., O'Mahony B., De Kleijn P., Bedford M., Batorova A., Blatny J., Jansone K., Astermark J., Crato M., D'Oiron R., Dougall A., Fijnvandraat K., Gronhaug S., Jimenez-Yuste V., Jokic M., Lobet S., Nolan B., Peyvandi F., Ryan A., European principles of inhibitor management in patients with haemophilia: Implications of new treatment options, Orphanet Journal of Rare Diseases, 15, (1), 2020 Journal Article, 2020 DOI

Final Results of PUPs B-LONG Study: Evaluating Safety and Efficacy of rFIXFc in Previously Untreated Patients with Haemophilia B( abstract), B. Nolan, A. Klukowska, A. Shapiro, A. Rauch, M. Recht, M. Ragni, J. Curtin, S. Gunawardena, S. Poloskey, D. Jayawardene, B. Winding, K. Fischer, R. Liesner, Research and Practice in Thrombosis and Hemostasis, ISTH Conference 2020, On line, July 2020, 4 ( suppl1), 2020 Poster, 2020 URL

Saad Z Ahmed, Michelle O'Rourke, Vince Jenkins, Caitriona Keenan, Irene Ellen Regan, Beatrice Nolan, Similar Pattern of Increase in FIX Levels in Female Carriers and Males with Hemophilia B Leyden, Blood , 62nd ASH Annual Meeting and Exposition, On line, 5-8 Dec 2020, 136( Supplement 1), 2020, pp19 - 20 Poster, 2020 URL

Beatrice Nolan, Anna Klukowska, Amy D Shapiro , Antoine Rauch, Michael Recht, Margaret V. Ragni, Julie Curtin, Sriya Gunawardena, Stacey Poloskey, Deepthi Jayawardene, Bent Winding, Kathelijn Fischerand Raina Liesner, Final Results of PUPs B-LONG Study: Evaluating Safety and Efficacy of rFIXFc in Previously Untreated Patients with Haemophilia B, 62nd ASH Annual Meeting and Exposition, On line, 5-8 Dec 2020, 2020 Poster, 2020 URL

Nolan B., Mahlangu J., Pabinger I., Young G., Konkle B.A., Barnes C., Nogami K., Santagostino E., Pasi K.J., Khoo L., Winding B., Yuan H., Fruebis J., Rudin D., Oldenburg J., Recombinant factor VIII Fc fusion protein for the treatment of severe haemophilia A: Final results from the ASPIRE extension study, Haemophilia, 26, (3), 2020, p494 - 502, p494-502 Journal Article, 2020 DOI

Ahmed S.Z., O'Rourke M., Jenkins V., Regan I., Nolan B., Progressive increase in FIX level in males with haemophilia B Leyden and c.35G > A mutation in early childhood not related to androgen effect, British Journal of Haematology, 189, (6), 2020, pe262 - e265, pe262-e265 Journal Article, 2020 DOI

Andersson N.G., Wu R., Carcao M., Claeyssens-Donadel S., Kobelt R., Liesner R., Makipernaa A., Ranta S., Ljung R., Auerswald G., Barnes C., Chalmers E., Chambost H., Clausen N., Dunn A.L., Escuriola Ettinghausen C., Fischer K., Fijnvandraat K., van Geet C., Hoffmann M., Kavakli K., Kenet G., Konigs C., Kurnik K., Manco-Johnson M., Mancuso M.E., Molinari C., Muntean W., Nolan B., Perez Garrido R., Platokouki E., Rafowicz A., Santagostino E., Shapiro A., Thomas A., Williams M., Long-term follow-up of neonatal intracranial haemorrhage in children with severe haemophilia, British Journal of Haematology, 190, (2), 2020, pe101 - e104, pe101-e104 Journal Article, 2020 DOI

Saad Ahmed, Michelle O'Rourke, Irene Regan, Vince Jerkins, Beatrice Nolan, New insights in to Haemophilia B Leyden, European Haematology Association Annual Congress, On line, 2020, 2020 Oral Presentation, 2020

Van Den Berg H.M., Mancuso M.E., Konigs C., D'Oiron R., Platokouki H., Mikkelsen T.S., Motwani J., Nolan B., Santagostino E., ITI treatment is not first-choice treatment in children with hemophilia A and low-responding inhibitors: Evidence from a PedNet study, Thrombosis and Haemostasis, 120, (8), 2020, p1166 - 1172, p1166-1172 Journal Article, 2020 DOI

Königs C, Ozelo MC, Dunn A, Kulkarni R, Nolan B, Brown SA, Liesner R, Schiavulli M, Gunawardena S, Mukhopadhyay S, Jayawardene D, Winding B, Carcao M. , Final Results of PUPs A-LONG Study: Evaluating Safety and Efficacy of rFVIIIFc in Previously Untreated Patients with Haemophilia A, Research and Practice in Thrombosis and Haemostasis, ISTH Conference 2020, On line, July 2020, 4 ( suppl1), 2020 Oral Presentation, 2020 URL

Regan I, Pillion C, Riordan M, Nolan B. , Antithrombin Activity Level below 60% in Children Has Implications for Heparin (LMWH) Dosing, Research and Practice in Thrombosis and Haemostasis, ISTH 2020, On line, 4 ( suppl1), 2020 Oral Presentation, 2020 URL

Regan IE, Brady B, Kavanagh M, Kelly M, Nolan, B, Von willebrand disease reclassification in a national paediatric comprehensive care centre, Archives of Disease in Childhood, Royal College of Paediatrics and Child Health, 9th Europaediatrics Congress, 13-15 June, Dublin, Ireland 2019, Dublin, 2019, 2019, (104 ( Suppl3)), Brirish Medical Journal, 2019 Oral Presentation, 2019

Andersson N.G., Chalmers E.A., Kenet G., Ljung R., Makipernaa A., Chambost H., Mode of delivery in hemophilia: Vaginal delivery and Cesarean section carry similar risks for intracranial hemorrhages and other major bleeds, Haematologica, 104, (10), 2019, p2100 - 2106, p2100-2106 Journal Article, 2019 DOI

Sweetman D, Kelly LA, Zareen Z, Nolan B, Murphy J, Boylan G, Donoghue V, Molloy EJ., Coagulation Profiles Are Associated With Early Clinical Outcomes in Neonatal Encephalopathy., Frontiers in pediatrics, 2019 Journal Article, 2019 DOI

Martin, Therese, Moore, Mary, Melody, Laura, Nolan, Beatrice, Snow, Aisling, Govender, Pradeep, Blackburn, Carol, Going out on a (clotted) limb - an interesting case of paget-schroetter syndrome in a young adolescent, BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, 2019 Conference Paper, 2019 DOI

Carcao M., Escuriola-Ettingshausen C., Santagostino E., Oldenburg J., Liesner R., Nolan B., Batorova A., Haya S., Young G., The changing face of immune tolerance induction in haemophilia A with the advent of emicizumab, Haemophilia, 25, (4), 2019, p676 - 684, p676-684 Journal Article, 2019 DOI

Mary Kavanagh, Imelda Kelly, Caitriona Ferry, Bridin Brady, Irene Regan, Beatrice Nolan, Review of paediatric patients with severe factor X deficiency in ireland , Archives of Disease in Childhood, Royal College of Paediatrics and Child Health, 9th Europaediatrics Congress, 13-15 June, Dublin, Ireland 2019, Dublin, 2019, Brirish Medical Journal, 2019 Poster, 2019 URL

Eliwan H.O., Watson W.R.G., Regan I., Philbin B., O'hare F.M., Strickland T., O'neill A., O'rourke M., Blanco A., Healy M., Nolan B., Smith O., Molloy E.J., Pediatric intensive care: Immunomodulation with activated protein C ex vivo, Frontiers in Pediatrics, 7, (SEP), 2019 Journal Article, 2019 DOI

Giangrande P.L.F., Hermans C., O'Mahony B., De Kleijn P., Bedford M., Batorova A., Blatny J., Jansone K., Astermark J., Bok A., Crato M., D'Oiron R., Dougall A., Fijnvandraat K., Gronhaug S., Jimenez-Yuste V., Jokic M., Lobet S., Nolan B., Peyvandi F., Ryan A., European principles of inhibitor management in patients with haemophilia, Orphanet Journal of Rare Diseases, 13, (1), 2018 Journal Article, 2018 DOI

Margaret Ragni, Roshni Kulkarni, K. John Pasi, Kathelijn Fischer, Johnny Mahlangu, Amy Shapiro, Beatrice Nolan, Johannes Oldenburg, Tadashi Matsushita, Annemieke Willemze, Huixing Yuan, Dan Rudin, B-YOND Final Results Confirm Established Safety, Sustained Efficacy, and Extended Dosing Interval for Up to 4 Years of Treatment With rFIXFc in Previously Treated Subjects With Severe Hemophilia B, Blood, 60th ASH Annual Meeting and Exposition, 2018, 132 ( supplement 1), 2018, pp1214 - 1214 Poster, 2018 URL

Beatrice Nolan, Johnny Mahlangu, Guy Young, Barbara A Konkle, K. John Pasi, MB, ChB, PhD FRCP, FRCPath, FRCPCH, Johannes Oldenburg, MD PhD, Keiji Nogami, MDPhD, Nikola Tripkovic, Huixing Yuan, Dan Rudin, ASPIRE Final Results Confirm Established Safety and Sustained Efficacy for Up to 4 Years of Treatment With rFVIIIFc in Previously Treated Subjects With Severe Hemophilia A, Blood, 6oth ASH Annual Meeting and Exposition, 2018, 132 ( supplement 1), 2018, pp1192- Poster, 2018 URL

Pasi K.J., Fischer K., Ragni M., Nolan B., Perry D.J., Kulkarni R., Ozelo M., Mahlangu J., Shapiro A.D., Baker R.I., Bennett C.M., Barnes C., Oldenburg J., Matsushita T., Yuan H., Ramirez-Santiago A., Pierce G.F., Allen G., Mei B., Long-term safety and efficacy of extended-interval prophylaxis with recombinant factor IX Fc fusion protein (rFIXFc) in subjects with haemophilia B, Thrombosis and Haemostasis, 117, (3), 2017, p508 - 518, p508-518 Journal Article, 2017 DOI

Ruth Elizabeth Hunter Nolan1,2, Eibhlin Mc Laughlin1 , Yvonne Duane1 , Ann O' Sullivan2 , Kevin Ryan2 , Niamh O' Connell2 , Beatrice Nolan1, Adolescent feedback on the Haemophilia Transition Programme between Our Lady's Children's Hospital and St. James's Hospital Dublin Ireland. , International Journal of Integrated Care, 17th International Conference on Integrated Care,, Dublin, 8-10 May 2017, 17, (5), 2017 Oral Presentation, 2017 URL

Malone A., Wlodarski M., Nolan B., Smyth L., Smith O.P., Transient myeloproliferative disorder in an infant with PTPN11 mutation, British Journal of Haematology, 177, (1), 2017, p11- Journal Article, 2017 DOI

Fischer K., Kulkarni R., Nolan B., Mahlangu J., Rangarajan S., Gambino G., Diao L., Ramirez-Santiago A., Pierce G.F., Allen G., Recombinant factor IX Fc fusion protein in children with haemophilia B (Kids B-LONG): results from a multicentre, non-randomised phase 3 study, The Lancet Haematology, 4, (2), 2017, pe75 - e82, pe75-e82 Journal Article, 2017 DOI

Andersson N.G., Auerswald G., Barnes C., Carcao M., Dunn A.L., Fijnvandraat K., Hoffmann M., Kavakli K., Kenet G., Kobelt R., Kurnik K., Liesner R., Makipernaa A., Manco-Johnson M.J., Mancuso M.E., Molinari A.C., Nolan B., Perez Garrido R., Petrini P., Platokouki H.E., Shapiro A.D., Wu R., Ljung R., Intracranial haemorrhage in children and adolescents with severe haemophilia A or B " the impact of prophylactic treatment, British Journal of Haematology, 179, (2), 2017, p298 - 307, p298-307 Journal Article, 2017 DOI

Fischer, K. and Iorio, A. and Hollingsworth, R. and Makris, M. and Watson, H. and Rae, J. and Platokouki, H. and Pergantou, H. and Katsarou, O. and Theodossiades, G. and Nomikou, E. and Parra, R. and Alonso, S. and Klamroth, R. and Kubicek, C. and Wilde, J. and Dunkley, T. and Oldenburg, J. and Schmickler, D. and Ackroyd, S. and Mirza, L. and Batorova, A. and Jankovicova, D. and Auerswald, G. and Buehrlen, M. and Penka, M. and Smejkal, P. and Blatny, J. and Zapletal, O. and Hermans, C. and Lambert, C. and Tagariello, G. and Radossi, P. and Nolan, B. and Brady, B. and O'Donnell, J. and Singleton, E. and Thomas, A. and Shea, I. and Morfini, M. and Linari, S. and de Moerloose, P. and Boehlen, F. and Campbell Tait, R. and Brodie, N. and Chalmers, E. and Gibson, A. and Meijer, K. and Tamminga, R. and Lassila, R. and Armstrong, E. and Zulfikar, B. and Ozdemir, N. and Kavakli, K. and Balkan, C. and Jurgutis, R. and Gailiute, N. and Peerlinck, K. and Geet, C.V. and Goudemand, J. and Wibaut, B. and Diniz, M.J. and Antunes, M. and Liesner, R. and Khair, K. and Laffan, M. and Patel, S. and Thynn Yee, T. and Harrington, C. and Pasi, J. and Bowles, L. and Bevan, D. and Madan, B. and Negrier, C. and Ringenbach, S. and Mingot Castellano, M.E. and Astermark, J. and Lindvall, K. and Gatt, A. and Hay, C.R.M. and Grey, P. and Will, A. and Hague, A. and Peyvandi, F. and Mancuso, M.E. and Schved, J.F. and Rousseau, F. and Kurnik, K. and Bidlingmaier, C. and Rocino, A. and Hanley, J. and Talks, K. and Antoniades, M. and Zanon, E. and Bon, E.D. and Lambert, T. and Rothschild, C. and Matingou, M. and Tagliaferri, A. and Rivolta, G.F. and Iorio, A. and Marchesini, E. and Fraga, C. and Cunha-Ribeiro, L. and Carvalho, M. and Komrska, V. and Pindurova, E. and Lejniece, S. and Kluce, G. and Leebeek, F. and Cnossen, M. and Makris, M. and Lockley, C. and Payne, J. and Vidler, V. and Lissitchkov, T. and Raia, P. and Holmstre om, M. and Garipidou, V. and Vakalopoulou, S. and Serban, M. and Mihailov, M.-D. and Schinco, P. and Valeri, F. and Schutgens, R. and Bonanad, S. and Cid, A.R. and Castaman, G. and Pabinger, I. and Reitter, S.-E. and Male, C. and Thom, K. and Windyga, J. and Piorowski, M. and Schmugge, M. and Albisetti, M., FVIII inhibitor development according to concentrate: Data from the EUHASS registry excluding overlap with other studies, Haemophilia, 22, (1), 2016, pe36-e38 Journal Article, 2016 DOI

Guy Young, Raina Liesner, K John Pasi, Beatrice Nolan, Stefan Lethagen, Lynda M Cristiano, Elisa Tsao, Bent Winding, Johnny Mahlangu, Longitudinal Analysis of Long-Term Safety and Efficacy of Recombinant Factor VIII Fc Fusion Protein (rFVIIIFc) in Previously Treated Children with Severe Hemophilia a, Blood, ASH Annual Meeting and Exposition, 2016, 128, (22), 2016, pp1414- Poster, 2016 URL

Nolan B., Mahlangu J., Perry D., Young G., Liesner R., Konkle B., Rangarajan S., Brown S., Hanabusa H., Pasi K.J., Pabinger I., Jackson S., Cristiano L.M., Li X., Pierce G.F., Allen G., Long-term safety and efficacy of recombinant factor VIII Fc fusion protein (rFVIIIFc) in subjects with haemophilia A, Haemophilia, 22, (1), 2016, p72 - 80, p72-80 Journal Article, 2016 DOI

Michael Wang, MD, K John Pasi, Ingrid Pabinger, Prof, Bryce A. Kerlin, Roshni Kulkarni, MD, Beatrice Nolan, Raina Liesner, Simon A Brown, Hideji Hanabusa, Elisa Tsao, Bent Winding, Stefan Lethagen, Nisha Jain, Long-Term Efficacy and Quality of Life with Recombinant Factor VIII Fc Fusion Protein (rFVIIIFc) Prophylaxis in Pediatric, Adolescent, and Adult Subjects with Target Joints and Severe Hemophilia a, Blood, ASH Annual Meeting and Exposition, 2016, 128, (22), 2016, pp3791- Poster, 2016 URL

Ljung R., Kenet G., Mancuso M.E., Kaleva V., Rusen L., Tseneklidou-Stoeter D., Michaels L.A., Shah A., Hong W., Maas Enriquez M., Kaleva V., Stoyanova-Deleva A., Blanchette V., Dower N., Clausen N., Kardos M., Kiss C., Zombori M., Nolan B., Kenet G., Santagostino E., Zanon E., Luciani M., Kovalova Z., Rageliene L., Dobaczewski G., Klukowska A., Mlynarkski W., Serban M., Rusen L., Uscatescu V., Kerlin B., Ahuja S., Gruppo R., Singleton T., BAY 81-8973 safety and efficacy for prophylaxis and treatment of bleeds in previously treated children with severe haemophilia A: Results of the LEOPOLD Kids Trial, Haemophilia, 22, (3), 2016, p354 - 360, p354-360 Journal Article, 2016 DOI

Jonathan M. Ducore, Kathelijn Fischer, Roshni Kulkarni, Beatrice Nolan, Carolyn M. Bennett, David J Perry, Huixing Yuan, Alejandra Ramirez-Santiago, Francesca Ferrante, Stefan Lethagen, Long Term Safety and Efficacy of Recombinant Factor IX Fc Fusion Protein (rFIXFc) Prophylaxis in Children with Hemophilia B: Interim Results of the B-Yond Extension Study, Blood, ASH Annual Meeting and Exposition, 2016, 128, (22), 2016, pp4976 - 4976 Poster, 2016 URL

Roshni Kulkarni, Beatrice Nolan, Carolyn M. Bennett, Kathelijn Fischer, David J Perry, Christopher Barnes, Huixing Yuan, Alejandra Ramirez-Santiago, Glenn F Pierce, Baisong Mei, Clinical Outcomes in Children with Hemophilia B Treated Long Term with rFIXFc: Interim Results of the B-YOND Extension Study, Blood , ASH Annual Meeting and Exposition, 126, (23), 2015 Poster, 2015 URL

Fischer K., Iorio A., Lassila R., Peyvandi F., Calizzani G., Gatt A., Lambert T., Windyga J., Gilman E.A., Makris M., Inhibitor development in non-severe haemophilia across Europe, Thrombosis and Haemostasis, 114, (4), 2015, p670 - 675, p670-675 Journal Article, 2015 DOI

Nijdam A., Altisent C., Carcao M.D., Cid A.R., Claeyssens-Donadel S., Kurnik K., Ljung R., Nolan B., Petrini P., Platokouki H., Rafowicz A., Thomas A.E., Fischer K., Bleeding before prophylaxis in severe hemophilia: Paradigm shift over two decades, Haematologica, 100, (3), 2015, pe84 - e86, pe84-e86 Journal Article, 2015 DOI

Ryan KM, O'Brien K, Regan I, O'Byrne JM, Moore D, Kelly PM, Noel J, Butler J, Nolan B, Kiely PJ, The prevalence of abnormal preoperative coagulation tests in pediatric patients undergoing spinal surgery for scoliosis, Spine J, 15, (6), 2015, p1217 - 1222 Journal Article, 2015

Young G., Mahlangu J., Kulkarni R., Nolan B., Liesner R., Pasi J., Barnes C., Neelakantan S., Gambino G., Cristiano L.M., Pierce G.F., Allen G., Recombinant factor VIII Fc fusion protein for the prevention and treatment of bleeding in children with severe hemophilia A, Journal of Thrombosis and Haemostasis, 13, (6), 2015, p967 - 977, p967-977 Journal Article, 2015 DOI

Nijdam A., Kurnik K., Liesner R., Ljung R., Nolan B., Petrini P., Fischer K., How to achieve full prophylaxis in young boys with severe haemophilia A: Different regimens and their effect on early bleeding and venous access, Haemophilia, 21, (4), 2015, p444 - 450, p444-450 Journal Article, 2015 DOI

V. Dvorakova, B. Nolan, A. Broderick,E.J. MacDermott and R. Watson, Neonatal lupus erythematosus with life-threatening gastrointestinal bleeding, British Journal of Dermatology, 94th Annual Meeting of the British-Association-of-Dermatologists, Glasgow, UK, 1-3 July 014, 171 ( suppl 1), 2014 Poster, 2014 URL

Clausen, N and Petrini, P and Claeyssens-Donadel, S and Gouw, SC and Liesner, R and {PedNet and Research of Determinants of Inhibitor development (RODIN) Study Group, Similar bleeding phenotype in young children with haemophilia A or B: a cohort study, Haemophilia : the official journal of the World Federation of Hemophilia, 20, (6), 2014, p747â€"755 Journal Article, 2014 DOI

Guy Young1, Johnny Mahlangu2, Roshni Kulkarni3, Beatrice Nolan* 4, Raina Liesner5, John Pasi6, Christopher Barnes7, Srividya Neelakantan8, Giulia Gambino8, Lynda M. Cristiano8, Chris Barnowski8, Glenn F. Pierce8, Geoff Allen8, KIDS A-LONG: SAFETY, EFFICACY, AND PHARMACOKINETICS OF LONG-ACTING RECOMBINANT FACTOR VIII FC FUSION PROTEIN (RFVIIIFC) IN PREVIOUSLY-TREATED PAEDIATRIC SUBJECTS WITH HAEMOPHILIA A, Haematologica, 99, (supplement 1), 2014 Journal Article, 2014

Eliwan HO, O'Hare FM, Watson WR, O'Neill A, Molloy EJ, Neonatal Brain Injury and Systemic Inflammation: Modulatin by Activated Protein c ex vivo, Clinical Exp Immunology, In Press, 2014 Journal Article, 2014

Nabialek T, Pinnamaneni R, Saleemi MS, Nolan B, Corcoran JD, Intra-hepatic haemorrhage and shock during post-natal period, in two brothers with haemophilia, Irish Medical Journal, 107, (8), 2014, p259 - 260 Journal Article, 2014 URL URL URL

Carcao, Manuel D and van den Berg, H Marijke and Ljung, Rolf and Mancuso, Maria Elisa and {PedNet and the Rodin Study Group, Correlation between phenotype and genotype in a large unselected cohort of children with severe hemophilia A, Blood, 121, (19), 2013, p3946â€"52, S1 Journal Article, 2013 DOI

Gouw, Samantha C and van den Berg, H Marijke and Fischer, Kathelijn and Auerswald, GÃŒnter and Carcao, Manuel and Chalmers, Elizabeth and Chambost, Hervé and Kurnik, Karin and Liesner, Ri and Petrini, Pia and Platokouki, Helen and Altisent, Carmen and Oldenburg, Johannes and Nolan, Beatrice and Garrido, Rosario Pérez and Mancuso, M Elisa and Rafowicz, Anne and Williams, Mike and Clausen, Niels and Middelburg, Rutger A and Ljung, Rolf and van der Bom, Johanna G and {PedNet and Research of Determinants of INhibitor development (RODIN) Study Group, Intensity of factor VIII treatment and inhibitor development in children with severe hemophilia A: the RODIN study, Blood, 121, (20), 2013, p4046â€"4055 Journal Article, 2013 DOI

Gouw, Samantha C and van der Bom, Johanna G and Ljung, Rolf and Escuriola, Carmen and Cid, Ana R and Claeyssens-Donadel, SégolÚne and van Geet, Christel and Kenet, Gili and MÀkipernaa, Anne and Molinari, Angelo Claudio and Muntean, Wolfgang and Kobelt, Rainer and Rivard, George and Santagostino, Elena and Thomas, Angela and van den Berg, H Marijke and {PedNet and RODIN Study Group, Factor VIII products and inhibitor development in severe hemophilia A, The New England journal of medicine, 368, (3), 2013, p231â€"239 Journal Article, 2013 DOI

, Audit of bleeding complications & cost ofdental treatment for children with hereditarybleeding disorders using a new treatmentprotocolU. RAO1,*, I. KELLY1, M. KAVANAGH1,B. BRADY1, K. FITZGERALD2, B. NOLAN1,P. FLEMING, Haemophilia, 19, (s2), 2013, p10-82 Journal Article, 2013 DOI

(ed.), Abstracts of the XXX International Congress of the World Federation of Hemophilia. July 8-12, 2012. Paris, France, 18 Suppl 3, 2012, 1â€"226 p Proceedings of a Conference, 2012 DOI

, Low risk of inhibitor formation in haemophilia A patients following en masse switch in treatment to a third generation full length plasma and albumin-free recombinant factor VIII product (ADVATE®), Haemophilia, 2011 Journal Article, 2011

White, M., Twomey, A., Donoghue, V., Mac Keogh, L., Nolan, B., O'Carroll, T., Murphy, J.F.A., Molloy, E.J., Decreased fibrinogen levels are associated with severe intraventricular hemorrhage in very low birth weight (VLBW) infants, Journal of Neonatal-Perinatal Medicine, 4, (2), 2011, p133-136 Journal Article, 2011 DOI

Jenkins PV, Egan H, Keenan C, O'Shea E, Smith OP, Nolan B, White B, O'Donnell J., Mutation analysis of haemophilia B in the Irish population: increased prevalence caused by founder effect., Haemophilia, 14, (4), 2008, p717-22 Journal Article, 2008 DOI

Gleeson, Michelle O†Rourke and Philbin, Brian and Nolan, Beatrice, Poster presentation Application of the US National Institute of Health (NIH) 2008 guidelines for von Willebrand Disease in a National Paediatric Comprehensive Care Centre. Irene E. Regan and Aine Burke, Orla M Cormack, Christopher Fox, Mary E, 2008 Journal Article, 2008

Iqbal R, Mulvihill NT, Nolan B, Crean PA., Multivessel coronary thrombosis resulting from heparin induced thrombocytopenia., Irish medical journal, 100, (8), 2007, p569-571 Journal Article, 2007 DOI

Singleton E., Smith J., Kavanagh M., Nolan B., White B., Low risk of inhibitor formation in haemophilia patients after a change in treatment from Chinese hamster ovary cell-produced to baby hamster kidney cell-produced recombinant factor VIII, Thrombosis and Haemostasis, 98, (6), 2007, p1188 - 1192, p1188-1192 Journal Article, 2007 DOI

Hinchliffe R.F., Nolan B., Vora A.J., Stamps R., Neonatal pure red cell aplasia due to anti-M, Archives of Disease in Childhood: Fetal and Neonatal Edition, 91, (6), 2006 Journal Article, 2006 DOI

, Unsuspected haemophilia in children with a single swollen joint., BMJ (Clinical research ed.), 2003 Journal Article, 2003 DOI

Nolan B., Vidler V., Vora A., Makris M., Lesson of the week: Unsuspected haemophilia in children with a single swollen joint, British Medical Journal, 326, (7381), 2003, p151 - 152, p151-152 Journal Article, 2003 DOI

Ng J.-P., Nolan B., Chan-Lam D., Coup A.J., Mckenna D., Successful treatment of aplastic variant of hairy-cell leukemia with deoxycoformycin, Hematology, 7, (4), 2002, p259 - 262, p259-262 Journal Article, 2002 DOI

B. Nolan, B. White, J. Smith, C. O'Reily, B. Fitzpatrick and O. P. Smith, Desmopressin: therapeutic limitations in children and adults with inherited coagulation disorders, British journal of haematology, 109, (4), 2000, p865-9 Journal Article, 2000 URL

Mainwaring C.J., Walewska R., Snowden J., Wlnfield D.A., Ng J.P., Chan-Lam D., Nolan B., Booker D.J., Stamps R., Sokol R.J., Fatal cold anti-i autoimmune haemolytic anaemia complicating hairy cell leukaemia, British Journal of Haematology, 109, (3), 2000, p641 - 643, p641-643 Journal Article, 2000 DOI

Mitchell T.H., Nolan B., Henry M., Cronin C., Baker H., Greely G., Microalbuminuria in patients with non-insulin-dependent diabetes mellitus relates to nocturnal systolic blood pressure, American Journal of Medicine, 102, (6), 1997, p531 - 535, p531-535 Journal Article, 1997 DOI

Nolan B, Mitchell TH., Autonomic neuropathy with gastropathy and elevated urinary 5-hydroxy indole acetic acid in insulin-dependent diabetes mellitus., The American journal of gastroenterology, 91, (6), 1996, p1286 Journal Article, 1996 DOI

Gibson, L., Cronin, C., Nolan, B., Mitchell, T.H., A case of cerebral malaria, Journal of the Irish Colleges of Physicians and Surgeons, 25, (1), 1996, p17-18 Journal Article, 1996

Non-Peer-Reviewed Publications

Beatrice Nolan, Inhibitors in Haemophilia A, The Third International Medical Conference on Hemophilia, Thalassaemia and Sickle Cell Disease, Amman, Jordan, 2022, Jordanian Ministry of Health, Jordanian Thalassaemia and Hemophilia Society, World Federation of Hemophilia, Thalassemia International Federation Invited Talk, 2022

Beatrice Nolan, Prophylaxis for children with haemophilia, The Second International Medical Conference on Hemophilia, Thalassaemia and Sickle Cell Disease, Amman, Jordan, 26 -27 September , 2019, Jordanian Ministry of Health, Jordanian Thalassaemia and Hemophilia Society, World Federation of Hemophilia, Thalassemia International Federation Invited Talk, 2019

Beatrice Nolan, Hemophilia A (Case Based Presentation) ISTH Academy. Nolan B. 07/19/18; 223593 Topic: Hemophilia - Clinical, Dublin, 19/07/2018, 2018 Invited Talk, 2018

Beatrice Nolan, ITI in era of Emicizumab, 64th Annual Meeting of Scientific and Standardization Committee of ISTH, Dublin, 20 July 2018, 2018, ISTH SSC Invited Talk, 2018

Research Expertise

Keywords

Blood transfusion; Clinical research, trials; Coagulation biochemistry and disorders; Drug development and evaluation; Haemotology; Human blood transfusion, risk managment; Inflammation and coagulation syndromes; Medical Sciences, Research; Medicine; Thrombosis and haemostasis

Recognition

Memberships

Fellow of Royal College of Pathologists 2002

Member of Royal College of Physicians of Ireland 1995

Fellow of Faculty of Pathology , Royal College of Physicians of Ireland 2002

Member of Royal Academy of Medicine in Ireland

Member of Royal Society of Medicine

Member of European Association of Haemophilia and Allied Disorders