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Dr. Sinead Duggan
Senior Research Fellow, Surgery

Biography

Dr Sinead Duggan is a Senior Research Fellow (part-time) in the Department of Surgery, School of Medicine, Trinity College Dublin, and is based in the Trinity Centre for Health Sciences in Tallaght University Hospital. Having originally graduated from TCD/DIT with a first class honours degree in Nutrition & Dietetics (2012), Sinead works with Professor Kevin Conlon and manages his research team. Sinead completed her PhD (Dept Surgery, TCD) in 2014 having won a Health Professional's Fellowship grant from the Health Research Board in 2009. Since then, Sinead has been a co-applicant on several successful Meath Foundation grant applications, including two in 2020 (for Dietary Intake in Chronic Pancreatitis and Time-Restricted Eating in PCOS). To date, Sinead has successfully co-supervised two PhD students (graduating in 2019 and 2020), and currently co-supervises an MD student (Department of Surgery) and a Research Masters student (Department of Clinical Medicine). Sinead has won several awards for her research including the INDI Researcher of the Year (2014) and The Cuthbertson Medal from the Nutrition Society of UK and Ireland (2016). To date, Sinead has authored/co-authored 28 peer-reviewed papers and four book chapters, and has participated in the development of National and International clinical guidelines for pancreatitis, including the HaPanEU European Guidelines and the Irish College of General Practicitioners Guidelines for chronic pancreatitis. Sinead is active within the School of Medicine working to help the School with the implementation of its Communications Strategy.

Publications and Further Research Outputs

Peer-Reviewed Publications

Mary E Phillips and Andrew D Hopper and John S Leeds and Keith J Roberts and Laura McGeeney and Sinead N Duggan and Rajesh Kumar, Consensus for the management of pancreatic exocrine insufficiency: UK practical guidelines, BMJ Open Gastroenterology, 8, (1), 2021, pe000643 Journal Article, 2021 DOI

Sinead N. Duggan, Donal B. O"Connor, Andrius Antanaitis, John R. Campion, Oladapo Lawal, Mohamed Ahmed, Ana Rakovac Tisdall, Mark Sherlock, Gerard Boran, Carel le Roux, James Gibney, Kevin C. Conlon, Metabolic dysfunction and diabetes mellitus during long-term follow-up of severe acute pancreatitis: A case-matched study, Pancreatology, 20, (5), 2020, p813--821 Journal Article, 2020

Dominguez-Munoz, J.E., Drewes, A.M., Lindkvist, B., Ewald, N., Czakó, L., Rosendahl, J., Löhr, J.M., Löhr, M., Besselink, M., Mayerle, J., Lerch, M.M., Akisik, F., Kartalis, N., Manfredi, R., Iglesias-Garcia, J., Haas, S.L., Keller, J., Boermeester, M.A., Werner, J., Dumonceau, J.M., Fockens, P., Drewes, A., Cheyan, G.O., Drenth, J.P., Hardt, P., de Madaria, E., Gheorghe, C., Lindgren, F., Schneider, A., Witt, H., Bollen, T., Boraschi, P., Frøkjær, J.B., Rudolf, S., Bruno, M., Dimcevski, G., Giovannini, M., Pukitis, A., Petrone, M., Oppong, K., Ammori, B., Friess, H., Izbiki, J.R., Ganeh, P., Salvia, R., Sauvanet, A., Barbu, S., Lyadov, V., Deprez, P., Gubergrits, N., Okhlobystiy, A.V., Arvanitakis, M., Costamagna, G., Pap, A., Andersson, R., Hauge, T., McKay, C., Regnér, S., Dite, P., Olesen, S.S., Duggan, S., Hopper, A., Phillips, M., Shvets, O., Vujasinovic, M., Czako, L., Piemonti, L., Kocher, H., Rebours, V., Stimac, D., Hegyi, P., Corrigendum to "Recommendations from the United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis" (Pancreatology (2018) 18(8) (847"854), (S1424390318306938), (10.1016/j.pan.2018.09.016)), Pancreatology, 20, (1), 2020, p148 Journal Article, 2020 DOI

Ní Chonchubhair H.M., Duggan S.N., Egan S.M., Kenyon M., O'Toole D., McManus R., Conlon K.C. , A high prevalence of genetic polymorphisms in idiopathic and alcohol-associated chronic pancreatitis patients in Ireland., HPB Journal, 2020 Journal Article, 2020

Duggan SN, O'Connor DB, Antanaitis A, Campion JR, Lawal O, Ahmed M, Tisdall AR, Sherlock M, Boran G, le Roux C, Gibney J, Conlon KC., Metabolic dysfunction and diabetes mellitus during long-term follow-up of severe acute pancreatitis: A case-matched study., Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 20, (5), 2020, p813-821 Journal Article, 2020 DOI

Griffin, O.M. and Duggan, S.N. and Ryan, R. and McDermott, R. and Geoghegan, J. and Conlon, K.C., Characterising the impact of body composition change during neoadjuvant chemotherapy for pancreatic cancer, Pancreatology, 2019, p850 - 857 Journal Article, 2019 DOI

Memba, R., Duggan, S.N., Jorba, R., Conlon, K.C., Dysbiosis in benign and malignant diseases of the exocrine pancreas, Microbiome and Metabolome in Diagnosis, Therapy, and other Strategic Applications, 2019, p357-364 Journal Article, 2019

Rahman, A. and O'Connor, D.B. and Gather, F. and Koscic, S. and Gilgan, J. and Mockler, D. and Bashir, Y. and Memba, R. and Duggan, S.N. and Conlon, K.C., Clinical Classification and Severity Scoring Systems in Chronic Pancreatitis: A Systematic Review, Digestive Surgery, 2019, p1-11 Journal Article, 2019 DOI

Dominguez-Munoz JE, Drewes AM, Lindkvist B, Ewald N, Czakó L, Rosendahl J, Löhr JM, HaPanEU/UEG Working Group., Recommendations from the United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis., Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 18, (8), 2018, p847-854 Journal Article, 2018 DOI

Duggan, S.N. and Conlon, K., Nutrition support in pancreatitis, 2018, 286-295pp Book, 2018 DOI

Ní Chonchubhair HM, Bashir Y, Dobson M, Ryan BM, Duggan SN, Conlon KC, The prevalence of small intestinal bacterial overgrowth in non-surgical patients with chronic pancreatitis and pancreatic exocrine insufficiency (PEI)., Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2018 Journal Article, 2018 DOI

Jegatheeswaran, S. and Puleston, J.M. and Duggan, S. and Hart, A. and Conlon, K.C. and Siriwardena, A.K., The practical management of chronic pancreatitis: A multidisciplinary symposium held at the annual meeting of the pancreatic society of Great Britain and Ireland, manchester 2016, Digestive Surgery, 36, (1), 2018, p41-45 Journal Article, 2018 DOI

Bashir, Y. and Chonchubhair, H.N. and Duggan, S.N. and Memba, R. and Ain, Q.U. and Murphy, A. and McMahon, J. and Ridgway, P.F. and Conlon, K.C., Systematic review and meta-analysis on the effect of obesity on recurrence after laparoscopic anti-reflux surgery, Surgeon, 2018 Journal Article, 2018 DOI TARA - Full Text

Jegatheeswaran, S. and Puleston, J.M. and Duggan, S. and Hart, A. and Conlon, K.C. and Siriwardena, A.K., The Practical Management of Chronic Pancreatitis: A Multidisciplinary Symposium Held at the Annual Meeting of the Pancreatic Society of Great Britain and Ireland, Manchester 2016, Digestive Surgery, 2018 Journal Article, 2018 DOI

Duggan SN., Negotiating the complexities of exocrine and endocrine dysfunction in chronic pancreatitis., The Proceedings of the Nutrition Society, 76, (4), 2017, p484-494 Journal Article, 2017 DOI

Duggan S.N, Ewald N, Kelleher L, Griffin O, Gibney J, Conlon K.C, The nutritional management of type 3c (pancreatogenic) diabetes in chronic pancreatitis, European Journal of Clinical Nutrition, 71, (1), 2017, p3 - 8 Journal Article, 2017 URL DOI

Duggan, S.N., Conlon, K.C., Pancreatogenic type 3c diabetes: Underestimated, underappreciated and poorly managed, Practical Gastroenterology, 41, (5), 2017, p14-23 Journal Article, 2017

Ní Chonchubhair H.M, Bashir Y, McNaughton D, Barry J.M, Duggan S.N, Conlon K.C, Hospital discharges and patient activity associated with chronic pancreatitis in Ireland 2009â€"2013, Pancreatology, 17, (1), 2017, p56 - 62 Journal Article, 2017 DOI URL

Löhr JM, Dominguez-Munoz E, Rosendahl J, Besselink M, Mayerle J, Lerch MM, Haas S, Akisik F, Kartalis N, Iglesias-Garcia J, Keller J, Boermeester M, Werner J, Dumonceau JM, Fockens P, Drewes A, Ceyhan G, Lindkvist B, Drenth J, Ewald N, Hardt P, de Madaria E, Witt H, Schneider A, Manfredi R, Brøndum FJ, Rudolf S, Bollen T, Bruno M, HaPanEU/UEG Working Group., United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis (HaPanEU)., United European gastroenterology journal, 5, (2), 2017, p153-199 Journal Article, 2017 DOI

Memba R and Duggan SN and Ni Chonchubhair HM and Griffin OM and Bashir Y and O'Connor DB and Murphy A and McMahon J and Volcov Y and Ryan BM and Conlon KC, The potential role of gut microbiota in pancreatic disease: A systematic review., Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2017 Journal Article, 2017 DOI

Sinead N Duggan, Hazel M Ní Chonchubhair, Oladapo Lawal, Donal B O'Connor, Kevin C Conlon, Chronic pancreatitis: A diagnostic dilemma, World Journal of Gastroenterology, 22, (7), 2016, p2304 - 2313 Journal Article, 2016 TARA - Full Text URL

Duggan SN, Purcell C, Kilbane, M, O'Keane M, McKenna M, Gaffney P, Ridgway PF, Boran G, Conlon KC, An Association Between Abnormal Bone Turnover, Systemic Infl ammation, and Osteoporosis in Patients With Chronic Pancreatitis: A Case-Matched Study, The American Journal of Gastroenterology, 110, 2015, p336 - 345 Journal Article, 2015

De Marchi J, Bajwa R, Duggan SN, Magill P, Suspected coexistent osteoporosis and osteomalacia with atraumatic bilateral neck of femur fractures in a 53-year-old man without apparent risk factors., BMJ Case reports, (4), 2014 Journal Article, 2014

Duggan SN, Smyth ND, O'Sullivan M, Feehan S, Ridgway PF, Conlon KC., The prevalence of malnutrition and fat-soluble vitamin deficiencies in chronic pancreatitis., Nutr Clin Pract., 29, (3 ), 2014, p348 - 354 Journal Article, 2014 DOI

Duggan SN, Smyth ND, Murphy A, Macnaughton D, O'Keefe SJ, Conlon KC, High Prevalence of Osteoporosis in Patients With Chronic Pancreatitis: A Systematic Review and Meta-analysis., Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 12, (2), 2014, p219-28 Journal Article, 2014 DOI

Duggan SN, Malnutrition, deficiency, and nutritional practice in patients with acute and chronic pancreatitis, TCD, 2014 Thesis, 2014

Smyth ND, Neary E, Power S, Feehan S, Duggan SN, , Assessing Appropriateness of Parenteral Nutrition Usage in an Acute Hospital Published by: http://www.sagepublications.com On behalf of: The American Society for Parenteral & Enteral Nutrition Additional services and information for Nutrition in Clinical Practice can be found at: Email Alerts: http://ncp.sagepub.com/cgi/alerts Subscriptions: http://ncp.sagepub.com/subscriptions Reprints: http://www.sagepub.com/journalsReprints.nav Permissions: http://www.sagepub.com/journalsPermissions.nav What is This? >> OnlineFirst Version of Record - Dec 21, 2012 Downloaded from, Nutrition in Clincial Practice, 28, 2013, p232 - 236 Journal Article, 2013

Duggan Sinead N, Conlon Kevin C, Bone health guidelines in chronic pancreatitis, Gastroenterology, 145, (4), 2013, p911 - 911 Journal Article, 2013

Duggan S.N, Conlon K.C, A practical guide to the nutritional management of chronic pancreatitis, Practical Gastroenterology, 37, (6), 2013, p24 - 32 Journal Article, 2013 URL

Duggan S.N, Conlon K.C, Bone health guidelines for patients with chronic pancreatitis, Gastroenterology, 145, (4), 2013, p911- Journal Article, 2013 URL DOI

Duggan SN, Smyth ND, O'Sullivan M, Feehan S, Ridgway PF, Conlon KC, A transatlantic survey of nutrition practice in acute pancreatitis., Journal of human nutrition and dietetics : the official journal of the British Dietetic Association, 25, (4), 2012, p388-97 Journal Article, 2012

Duggan SN, O Sullivan M, Hamilton S, Feehan SM, Ridgway PF, Conlon KC, Patients with chronic pancreatitis are at increased risk for osteoporosis., Pancreas, 41, (7), 2012, p1119-24 Journal Article, 2012

Power, S., Smyth, N., Duggan, S., Roddy, M., Feehan, S., The nasal bridle: A useful approach to prevent the dislodgement of feeding tubes, e-SPEN, 5, (2), 2010 Journal Article, 2010

Duggan S, O'Sullivan M, Feehan S, Ridgway P, Conlon K, Nutrition treatment of deficiency and malnutrition in chronic pancreatitis: a review., Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, 25, (4), 2010, p362-70 Journal Article, 2010 DOI

Duggan S, Egan SM, Smyth ND, Feehan SM, Breslin N, Conlon KC, Blind bedside insertion of small bowel feeding tubes., Irish journal of medical science, 2009 Journal Article, 2009 DOI

Duggan S.N, Smyth N.D, Egan S.M, Roddy M, Conlon K.C, An assessment of the validity of enteral aspirate pH measurements made with commercial pH strips, e-SPEN, 3, (6), 2008 Journal Article, 2008 DOI URL

Research Expertise

Description

Dr Sinead Duggan's research interests include the nutritional management of acute and chronic pancreatitis, type 3c / pancreatogenic diabetes, brittle/labile diabetes in chronic pancreatitis, patient involvement in chronic pancreatitis research, exercise / physical activity in chronic pancreatitis, nutrient deficiency in chronic pancreatitis, epidemiology of chronic pancreatitis, economic burden of chronic pancreatitis, dietary intake in pancreatitis, the natural history of chronic pancreatitis, development of a clinical score in chronic pancreatitis, nutrition in pancreatic cancer, time-restricted eating / intermittent fasting in PCOS, the use of digital technologies (mobile phone app) for the management of chronic pancreatitis

Projects

  • Title
    • Diabetes following severe acute pancreatitis
  • Summary
    • Patients who survived severe acute pancreatitis were recruited along with healthy matched non-pancreatitis control subjects. Subjects underwent an oral glucose tolerance test and insulin, glucagon, pancreatic polypeptide and c-peptide measured at intervals.
  • Funding Agency
    • Meath Foundation
  • Date From
    • 2014
  • Date To
    • 2019
  • Title
    • The Trinity Score: A clinical score for chronic pancreatitis
  • Summary
    • Comprehensive Department of Surgery pancreatic database interrogated to develop a clinical score for patients with chronic pancreatitis
  • Funding Agency
    • Meath Foundation
  • Date From
    • 2019
  • Date To
    • Ongoing
  • Title
    • Dietary intake in patients with chronic pancreatitis
  • Summary
    • Patients with late stage chronic pancreatitis recruited to measure dietary intake using food diaries and Vioscreen app. Objective is to determine both dietary intake and physical activity levels.
  • Funding Agency
    • Meath Foundation
  • Date From
    • 2019
  • Date To
    • 2022
  • Title
    • Intermittent fasting to reduce insulin in poly cystic ovarian syndrome
  • Funding Agency
    • Meath Foundation
  • Date From
    • 2021
  • Date To
    • 2023
  • Title
    • Natural History of chronic pancreatitis
  • Date From
    • 2020
  • Date To
    • 2022
  • Title
    • Nutrition in acute and chronic pancreatitis
  • Summary
    • PhD studies (2009-2014)
  • Funding Agency
    • Health Research Board
  • Date From
    • 2009
  • Date To
    • 2014
  • Title
    • Nutrition in patient with borderline resectable pancreatic cancer
  • Summary
    • PhD study co-supervisor. PhD awarded 2020.
  • Funding Agency
    • Health Research Board
  • Date From
    • 2016
  • Date To
    • 2020

Keywords

ACUTE PANCREATITIS; Chronic inflamation; CHRONIC PANCREATITIS; CHRONIC RELAPSING PANCREATITIS; CHRONIC-ALCOHOLIC PANCREATITIS; Clinical nutrition/malnutrition; Clinical research, trials; DIABETES; Diabetes and diabetic complications; diabetes control; DIABETES MELLITUS; DIET; Diet, nutrition and health; DIETARY ASSESSMENT; DIETARY GUIDELINES; DIETARY MANAGEMENT; Dietetic studies; Endocrine function and disease; ENTERAL NUTRITION; General surgery, upper GI, colorectal and breast; MALNUTRITION; Medicine; Metabolic syndrome & diabetes; Metabolism and metabolic diseases; Nutrient metabolism, obesity and clinical nutrition; NUTRITION; NUTRITION AND HEALTH; Oesophageal, gastric, intestinal and pancreatic diseases; OSTEOPOROSIS; PANCREAS; PANCREATITIS; Primary care; TYPE 2 DIABETES; TYPE 3c DIABETES; VITAMIN INTAKE; VITAMIN SUPPLEMENTATION

Recognition

Awards and Honours

Cutherbertson Award December 2016

INDI Researcher of the Year 2013

Honorary Lifetime Member of the Nutrition Interest Group of the PSGBI 2016

Health Research Board PhD Fellowship 2009-2014

Best Scientific Abstract: Irish Osteoporosis Scientific Meeting 2013

Best Clinical Abstract at the Irish Osteoporosis Society Meeting 2013

Best overall poster at the Pancreatic Society of Great Britain & Ireland Annual Meeting 2009

Two outstanding abstracts at ESPEN (top 10% ranking) 2008

Highest scoring Irish Abstract at ESPEN 2008

'Innovation in Dietetics' Bursary for attendance at ASPEN, USA 2007

SHS Clinical Award (Silver Medal) for best undergraduate clinical exam 2002

C&G Award for Best Undergraduate Thesis Presentation 2002

Memberships

Member of the Pancreatic Society of Great Britain & Ireland 2005 – Present

Irish Nutrition & Dietetics Institute (INDI) 2012 – Present