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Dr. Dania Movia
Senior Research Fellow, Trinity Translational Medicine Institute
Senior Research Fellow, CRANN

Biography

Dr Dania Movia is a Senior Research Fellow of the Department of Clinical Medicine. She received her PhD at Trinity College Dublin in 2012, and subsequently she was awarded a Special Purpose Certificate in Academic Practice by the same university in 2018.

Her current research work focuses on developing new, non-animal technologies (NATs) that can replace animal studies in cancer and lung toxicity research. These technologies are based on human cells growing as complex, 3D cultures in a dish, outside the human body. Her long-term research vision is a world where biomedical research is animal-free, and anti-cancer drug discovery can translate treatments in a timely and cost-effective manner, ensuring that patients always get the best therapy possible.

Among her academic duties, Dania lectures in the Trinity MSc in Molecular Medicine since 2016. On the research front, she was Principal Investigator in a grant funded by the John Hopkins' Center for Alternatives to Animal Testing (CAAT). At European level, she is involved as Trinity co-Principal Investigator in the EC-H2020 BIORIMA project. She is also part of the Scientific Advisory Panel of Animal-Free Research UK, Expert Panel member of the SAToRI-BTR project, and Topic Editor of the Frontiers Bioengineering and Biotechnology journal.

Publications and Further Research Outputs

Peer-Reviewed Publications

Dania Movia, Maroua Benhaddada, Jolanda Spadavecchia, Adriele Prina-Mello, Latest advances in combining gold nanomaterials with physical stimuli towards new responsive therapeutic and diagnostic strategies , Precision Nanomedicine, 3, (2), 2020, p495 - 524 Journal Article, 2020

Moustaoui H, Saber J, Djeddi I, Liu Q, Movia D, Prina-Mello A, Spadavecchia J, Lamy de la Chapelle M, Djaker N., A protein corona study by scattering correlation spectroscopy: a comparative study between spherical and urchin-shaped gold nanoparticles., Nanoscale, 11, (8), 2019, p3665-3673 Journal Article, 2019 DOI

Dania Movia, Despina Bazou, Adriele Prina-Mello, ALI multilayered co-cultures mimic biochemical mechanisms of the cancer cell-fibroblast cross-talk involved in NSCLC MultiDrug Resistance, BMC Cancer, 19, (1), 2019 Journal Article, 2019

Luisana Di Cristo, Sarah Mc Carthy, Keith Paton, Dania Movia, Adriele Prina-Mello, Interplay between oxidative stress and endoplasmic reticulum stress mediated- autophagy in unfunctionalised few-layer graphene-exposed macrophages, 2D Materials, 2018 Journal Article, 2018

Nanotoxicity in cancer research: technical protocols and tips considerations for the use of 3D tumour spheroids in, editor(s)Ferreira de Castro Gomes Andreia, Sárria Pereira Passos Marisa. , Unraveling the Safety Profile of Nanoscale Particles and Materials - From Biomedical to Environmental Applications, InTech, 2018, [Movia D., Prina-Mello A.] Book Chapter, 2018 TARA - Full Text

Di Cristo, L. and Maguire, C.M. and Mc Quillan, K. and Aleardi, M. and Volkov, Y. and Movia, D. and Prina-Mello, A., Towards the identification of an in vitro tool for assessing the biological behavior of aerosol supplied nanomaterials, International Journal of Environmental Research and Public Health, 15, (4), 2018 Journal Article, 2018 DOI TARA - Full Text

Adriele Prina-Mello and Dania Movia and Despina Bazou and Yuri Volkov and Adriele Prina-Mello, Multilayered Cultures of NSCLC cells grown at the Air-Liquid Interface allow the efficacy testing of inhaled anti-cancer drugs, Scientific Reports, 2018, p12920- Journal Article, 2018 TARA - Full Text DOI

Hutchinson D, Muller J, McCarthy JE, Gun'ko YK, Verma NK, Bi X, Di Cristo L, Kickham L, Movia D, Prina-Mello A, Volkov Y, Cadmium nanoparticles citrullinate cytokeratins within lung epithelial cells: cadmium as a potential cause of citrullination in chronic obstructive pulmonary disease, International Journal of Chronic Obstructive Pulmonary Disease , 13, 2018, p441 - 449 Journal Article, 2018 TARA - Full Text URL URL

Adriele Prina-Mello, Namrata Jain, Baiyun Liu, Jason I. Kilpatrick, Melissa A. Tutty, Alan P. Bell, Suzanne P Jarvis, Yuri Volkova, Dania Movia, Culturing substrates influence the morphological, mechanical and biochemical features of lung adenocarcinoma cells cultured in 2D or 3D, Tissue and Cell, 50, 2018, p15 - 30 Journal Article, 2018 DOI

Cristina Multari, Marta Miola, Sara Ferraris, Dania Movia, Kristina Žužek Rožman, Nina Kostevšek, Antonia Follenzi, Enrica Verné, Adriele Prina-Mello, Synthesis and characterization of silica-coated superparamagnetic iron oxide nanoparticles and interaction with pancreatic cancer cells, International Journal of Applied Ceramic Technology, 2018 Journal Article, 2018

Movia D., Di Cristo L., Alnemari R., McCarthy J. E., Moustaoui H., Lamy de la Chapelle M., Spadavecchia J., Volkov Y., Prina-Mello A., The curious case of how mimicking physiological complexity in in vitro models of the human respiratory system influences the inflammatory responses. A preliminary study focused on gold nanoparticles, Journal of Interdisciplinary Nanomedicine, 2, (2), 2017, p110 - 130 Journal Article, 2017 DOI

Moore C., Movia D., Smith R., Hanlon D., Lebre F., Lavelle E., Byrne H., Coleman J., Volkov Y., McIntyre J., Industrial grade 2D molybdenum disulphide (MoS2): an in vitro exploration of the impact on cellular uptake, cytotoxicity, and inflammation, 2D Materials, 4, (2), 2017 Journal Article, 2017 URL DOI

Di Cristo L, Movia D, Bianchi MG, Allegri M, Mohamed BM, Bell AP, Moore C, Pinelli S, Rasmussen K, Riego-Sintes J, Prina-Mello A, Bussolati O, Bergamaschi E., Proinflammatory Effects of Pyrogenic and Precipitated Amorphous Silica Nanoparticles in Innate Immunity Cells., Toxicological sciences : an official journal of the Society of Toxicology, 150, (1), 2016, p40-53 Journal Article, 2016 DOI

Di Cristo L, Movia D, Bianchi MG, Allegri M, Mohamed BM, Bell AP, Moore C, Pinelli S, Rasmussen K, Riego-Sintes J, Prina-Mello A, Bussolati O, Bergamaschi E., Proinflammatory Effects of Pyrogenic and Precipitated Amorphous Silica Nanoparticles in Innate Immunity Cells., Toxicological sciences : an official journal of the Society of Toxicology, 150, (1), 2016, p40-53 Journal Article, 2016 DOI

Di Cristo L, Movia D, Bianchi MG, Allegri M, Mohamed BM, Bell AP, Moore C, Pinelli S, Rasmussen K, Riego-Sintes J, Prina-Mello A, Bussolati O, Bergamaschi E., Proinflammatory Effects of Pyrogenic and Precipitated Amorphous Silica Nanoparticles in Innate Immunity Cells., Toxicological sciences : an official journal of the Society of Toxicology, 150, (1), 2016, p40-53 Journal Article, 2016 DOI

Di Cristo L, Movia D, Bianchi MG, Allegri M, Mohamed BM, Bell AP, Moore C, Pinelli S, Rasmussen K, Riego-Sintes J, Prina-Mello A, Bussolati O, Bergamaschi E., Proinflammatory Effects of Pyrogenic and Precipitated Amorphous Silica Nanoparticles in Innate Immunity Cells., Toxicological sciences : an official journal of the Society of Toxicology, 150, (1), 2016, p40-53 Journal Article, 2016 DOI

Spadavecchia J, Movia D, Moore C, Maguire CM, Moustaoui H, Casale S, Volkov Y, Prina-Mello A, Targeted polyethylene glycol gold nanoparticles for the treatment of pancreatic cancer: from synthesis to proof-of-concept in vitro studies., International journal of nanomedicine, 11, 2016, p791-822 Journal Article, 2016 DOI TARA - Full Text

Di Cristo L, Movia D, Bianchi MG, Allegri M, Mohamed BM, Bell AP, Moore C, Pinelli S, Rasmussen K, Riego-Sintes J, Prina-Mello A, Bussolati O, Bergamaschi E., Proinflammatory Effects of Pyrogenic and Precipitated Amorphous Silica Nanoparticles in Innate Immunity Cells., Toxicological sciences : an official journal of the Society of Toxicology, 150, (1), 2016, p40-53 Journal Article, 2016 DOI

Multilayered nanoparticles for personalized medicine: translation into clinical markets in, editor(s)Raj Bawa, Gerald F. Audette, Israel Rubinstein , Handbook of Clinical Nanomedicine: Nanoparticles, Imaging, Therapy and Clinical Applications, Pan Stanford Publishing, 2016, pp299 - 318, [Dania Movia, Craig Poland, Lang Tran, Yuri Volkov, Adriele Prina-Mello] Book Chapter, 2016 DOI

Di Cristo L, Movia D, Bianchi MG, Allegri M, Mohamed BM, Bell AP, Moore C, Pinelli S, Rasmussen K, Riego-Sintes J, Prina-Mello A, Bussolati O, Bergamaschi E., Proinflammatory Effects of Pyrogenic and Precipitated Amorphous Silica Nanoparticles in Innate Immunity Cells., Toxicological sciences : an official journal of the Society of Toxicology, 150, (1), 2016, p40-53 Journal Article, 2016 DOI

Moustaoui H, Movia D, Dupont N, Bouchemal N, Casale S, Djaker N, Savarin P, Prina-Mello A, De La Chapelle M.L, Spadavecchia J, Tunable Design of Gold(III)-Doxorubicin Complex-PEGylated Nanocarrier. the Golden Doxorubicin for Oncological Applications, ACS Applied Materials and Interfaces, 8, (31), 2016, p19946 - 19957 Journal Article, 2016 URL DOI

Di Cristo L, Movia D, Bianchi MG, Allegri M, Mohamed BM, Bell AP, Moore C, Pinelli S, Rasmussen K, Riego-Sintes J, Prina-Mello A, Bussolati O, Bergamaschi E., Proinflammatory Effects of Pyrogenic and Precipitated Amorphous Silica Nanoparticles in Innate Immunity Cells., Toxicological sciences : an official journal of the Society of Toxicology, 150, (1), 2016, p40-53 Journal Article, 2016 DOI

Di Cristo L, Movia D, Bianchi MG, Allegri M, Mohamed BM, Bell AP, Moore C, Pinelli S, Rasmussen K, Riego-Sintes J, Prina-Mello A, Bussolati O, Bergamaschi E., Proinflammatory Effects of Pyrogenic and Precipitated Amorphous Silica Nanoparticles in Innate Immunity Cells., Toxicological sciences : an official journal of the Society of Toxicology, 150, (1), 2016, p40-53 Journal Article, 2016 DOI

Di Cristo L, Movia D, Bianchi MG, Allegri M, Mohamed BM, Bell AP, Moore C, Pinelli S, Rasmussen K, Riego-Sintes J, Prina-Mello A, Bussolati O, Bergamaschi E., Proinflammatory Effects of Pyrogenic and Precipitated Amorphous Silica Nanoparticles in Innate Immunity Cells., Toxicological sciences : an official journal of the Society of Toxicology, 150, (1), 2016, p40-53 Journal Article, 2016 DOI

Dekkers S, Oomen AG, Bleeker EA, Vandebriel RJ, Micheletti C, Cabellos J, Janer G, Fuentes N, Vázquez-Campos S, Borges T, Silva MJ, Prina-Mello A, Movia D, Nesslany F, Ribeiro AR, Leite PE, Groenewold M, Cassee FR, Sips AJ, Dijkzeul A, van Teunenbroek T, Wijnhoven SW, Towards a nanospecific approach for risk assessment., Regulatory toxicology and pharmacology : RTP, 80, 2016, p46-59 Journal Article, 2016 DOI TARA - Full Text

Di Cristo L, Movia D, Bianchi MG, Allegri M, Mohamed BM, Bell AP, Moore C, Pinelli S, Rasmussen K, Riego-Sintes J, Prina-Mello A, Bussolati O, Bergamaschi E., Proinflammatory Effects of Pyrogenic and Precipitated Amorphous Silica Nanoparticles in Innate Immunity Cells., Toxicological sciences : an official journal of the Society of Toxicology, 150, (1), 2016, p40-53 Journal Article, 2016 DOI

Di Cristo L, Movia D, Bianchi MG, Allegri M, Mohamed BM, Bell AP, Moore C, Pinelli S, Rasmussen K, Riego-Sintes J, Prina-Mello A, Bussolati O, Bergamaschi E, Proinflammatory Effects of Pyrogenic and Precipitated Amorphous Silica Nanoparticles in Innate Immunity Cells., Toxicological sciences, 150, (1), 2016, p40-53 Journal Article, 2016 DOI TARA - Full Text

Di Cristo L, Movia D, Bianchi MG, Allegri M, Mohamed BM, Bell AP, Moore C, Pinelli S, Rasmussen K, Riego-Sintes J, Prina-Mello A, Bussolati O, Bergamaschi E., Proinflammatory Effects of Pyrogenic and Precipitated Amorphous Silica Nanoparticles in Innate Immunity Cells., Toxicological sciences : an official journal of the Society of Toxicology, 150, (1), 2016, p40-53 Journal Article, 2016 DOI

Di Cristo L, Movia D, Bianchi MG, Allegri M, Mohamed BM, Bell AP, Moore C, Pinelli S, Rasmussen K, Riego-Sintes J, Prina-Mello A, Bussolati O, Bergamaschi E., Proinflammatory Effects of Pyrogenic and Precipitated Amorphous Silica Nanoparticles in Innate Immunity Cells., Toxicological sciences : an official journal of the Society of Toxicology, 150, (1), 2016, p40-53 Journal Article, 2016 DOI

Di Cristo L, Movia D, Bianchi MG, Allegri M, Mohamed BM, Bell AP, Moore C, Pinelli S, Rasmussen K, Riego-Sintes J, Prina-Mello A, Bussolati O, Bergamaschi E., Proinflammatory Effects of Pyrogenic and Precipitated Amorphous Silica Nanoparticles in Innate Immunity Cells., Toxicological sciences : an official journal of the Society of Toxicology, 150, (1), 2016, p40-53 Journal Article, 2016 DOI

Di Cristo L, Movia D, Bianchi MG, Allegri M, Mohamed BM, Bell AP, Moore C, Pinelli S, Rasmussen K, Riego-Sintes J, Prina-Mello A, Bussolati O, Bergamaschi E., Proinflammatory Effects of Pyrogenic and Precipitated Amorphous Silica Nanoparticles in Innate Immunity Cells., Toxicological sciences : an official journal of the Society of Toxicology, 150, (1), 2016, p40-53 Journal Article, 2016 DOI

Bianca M Rotoli, Rita Gatti, Dania Movia, Massimiliano G Bianchi, Luisana Di Cristo, Ivana Fenoglio, Fabio Sonvico, Enrico Bergamaschi, Adriele Prina-Mello, Ovidio Bussolati, Identifying contact-mediated, localized toxic effects of MWCNT aggregates on epithelial monolayers: a single-cell monitoring toxicity assay, Nanotoxicology, 9, (2), 2015, p230-241 Journal Article, 2015 DOI

Mahfoud, O.K., Rakovich, T.Y., Prina-Mello, A., Movia, D., Alves, F., Volkov, Y., Detection of ErbB2: Nanotechnological solutions for clinical diagnostics, RSC Advances, 4, (7), 2014, p3422-3442 Review, 2014 DOI TARA - Full Text

Movia, D., Gerard, V., Maguire, C.M., Jain, N., Bell, A.P., Nicolosi, V., O'Neill, T., Scholz, D., Gun'ko, Y., Volkov, Y., Prina-Mello, A., A safe-by-design approach to the development of gold nanoboxes as carriers for internalization into cancer cells, Biomaterials, 35, (9), 2014, p2543-2557 Journal Article, 2014 DOI

Catherine A Schütz, Davide Staedler, Kieran Crosbie-Staunton, Dania Movia, Catherine Chapuis Bernasconi, Blanka Halamoda Kenzaoui, Adriele Prina-Mello, Lucienne Juillerat-Jeannere, Differential stress reaction of human colon cells to oleic-acid-stabilized and unstabilized ultrasmall iron oxide nanoparticles, International Journal of Nanomedicine, 9, 2014, p3481 - 3498 Journal Article, 2014 TARA - Full Text DOI

Singh, M., Movia, D., Mahfoud, O.K., Volkov, Y., Prina-Mello, A., Silver nanowires as prospective carriers for drug delivery in cancer treatment: An in vitro biocompatibility study on lung adenocarcinoma cells and fibroblasts, European Journal of Nanomedicine, 5, (4), 2013, p195-204 Journal Article, 2013 DOI

Toxicity of carbon nanotubes in, Handbook of Green Chemistry - Green Processes (- Green Nanoscience), Germany, Wiley - VCH, 2013, pp175 - 216 , [Movia D. and Giordani S.] Book Chapter, 2013

Bashir Mustafa Mohamed, Dania Movia, Anton Knyazev, Dominique Langevin, Anthony Mitchell Davies, Adriele Prina-Mello, Yuri Volkov, Citrullination as early-stage indicator of cell response to Single-Walled Carbon Nanotubes, Scientific Reports, 3, (1124), 2013, p1 - 7 Journal Article, 2013 DOI

Del Canto E., Natali M., Movia D. and Giordani S., Photo-controlled Uptake and Release of Zinc Metal Ions by Spiropyran receptors anchored to Single-Walled Carbon Nanotubes, Phys. Chem. Chem. Phys. , 14, (17), 2012, p6034 - 6043 Journal Article, 2012 TARA - Full Text DOI

Anja Schinwald, Fiona A Murphy, Adriele Prina-Mello, Craig A Poland, Fiona Byrne, Dania Movia, James R Glass, Janet C Dickerson, David A Schultz, Chris E Jeffree, William Macnee, Ken Donaldson, The threshold length for fiber-induced acute pleural inflammation: shedding light on the early events in asbestos-induced mesothelioma, Toxicological Sciences, 128, (2), 2012, p461 - 470 Journal Article, 2012 DOI

Thakur G., Micic M., Yang Y., Li W., Movia D., Giordani S., Zhang H. and Leblanc R., Conjugated Quantum Dots Inhibit the Amyloid β (1-42) Fibrillation Process, International Journal of Alzheimer's Disease, 2011, 2011, p502386 Journal Article, 2011 TARA - Full Text DOI

Del Canto E., Flavin K., Movia D., Giordani S., Oxidized Single-Walled Carbon Nanotubes: removal of carbonaceous functionalized material by washing with solvents or base, MRS Proceedings, 1362, 2011, pmrss11-1362-qq09-44 Journal Article, 2011 DOI

Del Canto E., Flavin K., Movia D., Navio C., Bittencourt C., Giordani S., A Critical Investigation of Defect Site Functionalization on Single Walled Carbon Nanotubes, Chemistry of Materials, 23, (1), 2011, p67-74 Journal Article, 2011 DOI

Movia D, Prina-Mello A, Bazou D, Volkov Y, Giordani S, Screening the Cytotoxicity of Single-Walled Carbon Nanotubes Using Novel 3D Tissue-Mimetic Models., ACS Nano, 5, (11), 2011, p9278-9290 Journal Article, 2011 DOI

Del Canto, E., Flavin, K., Movia, D., Navio, C., Bittencourt, C., Giordani, S., Critical investigation of defect site functionalization on single-walled carbon nanotubes, Chemistry of Materials, 23, (1), 2011, p67-74 Journal Article, 2011 DOI

Movia, D., Prina-Mello, A. , Volkov, Y. , Giordani, S, Determination of spiropyran cytotoxicity by high content screening and analysis for safe application in bionanosensing, Chemical Research in Toxicology , 23, (9), 2010, p1459 - 1466 Journal Article, 2010 DOI TARA - Full Text

Movia D., Del Canto E., Giordani S., Purified and Oxidized Single Walled Carbon Nanotubes as Robust Near IR Fluorescent Probes for Molecular Imaging, Journal of Physical Chemistry C, 114, (43), 2010, p18407-18413 Journal Article, 2010 DOI

Movia D., Del Canto E. and Giordani S., Spectroscopy of Single-Walled Carbon Nanotubes in Aqueous Surfactant Dispersion, physica status solidi (b), 246, (11-12), 2009, p2704 - 2707 Journal Article, 2009 DOI TARA - Full Text

Non-Peer-Reviewed Publications

Susan Dekkers, Agnes G Oomen, Eric AJ Bleeker, Rob J Vandebriel, Christian Micheletti, Joan Cabellos, Gemma Janer, Natalia Fuentes, Socorro Vázquez-Campos, Teresa Borges, Maria João Silva, Adriele Prina-Mello, Dania Movia, Fabrice Nesslany, Ana Ribeiro, Paulo Emílio Leite, Monique Groenewold, Flemming R Cassee, Adrienne JAM Sips, Aart Dijkzeul, Tom van Teunenbroek, Susan WP Wijnhoven, NANoREG Deliverable D 5.8-Decision tree for risk assessment of MNMs , 2016 Report, 2016

Gavigan-Imedio J.D., Movia D., Volkov Y., Prina-Mello A., Nanomedicine translational oncology: a perspective to cancer treatment, EuroNanoForum, Dublin, Ireland, June 2013, 2013 Oral Presentation, 2013

Movia D., Del Canto E., Giordani S., Purified and Oxidized SWNTs: potential NIR fluorescence probes for molecular imaging, ChemOnTubes 2010, Arcachon, France, 11-15/04/2010, 2010 Oral Presentation, 2010

Research Expertise

Description

Research areas: ► Oncological nanomedicine ► Tissue-mimetic in vitro cell models for cancer research ► Alternatives to animal research and 3Rs principle ► Medicinal chemistry ► Risk assessment of nanomaterials ► Nanotechnology

Projects

  • Title
    • Pre-clinical models for predicting the toxicity, absorption and biodistribution of inhaled nanomaterials in humans
  • Funding Agency
    • Johns Hopkins University Center for Alternatives to Animal Testing (CAAT)
  • Date From
    • 2018
  • Date To
    • 2020
  • Title
    • INEDITED - Improve NanomEDIcine Translation into clinical lung cancEr Drugs
  • Funding Agency
    • Irish Research Council
  • Date From
    • 2015
  • Date To
    • 2017

Keywords

Alternatives to Animal Testing; Biology; Biomaterials; Cellular Biology; Imaging Techniques; In vitro alternatives to animal studies; In vitro testing, trial methods; Lung cancer; Medicinal Chemistry; Nanochemistry; Nanomedicine; Nanotechnology; Pancreatic cancer; Physical Chemistry; Spectroscopy

Recognition

Representations

Scientific Advisory Panel member, Animal-Free Research UK. 2019

Expert Panel member, SAToRI-BTR project. 2019

Topic Editor for the Frontiers in Bioengineering and Biotechnology journal - Topic: Use of 3D Models in Drug Development and Precision Medicine: Advances and Outlook. 2019

Reviewer for several international scientific journals. Present

Awards and Honours

Research Award in recognition for the publication of an internationally peer-reviewed publication of the highest quality. 2012

Best Material Science Poster, 33rd Annual Microscopy Society of Ireland (MSI) meeting 2009

Paper of the Year 2012, Society of Toxicology Board 2012

Memberships

EACR (European Association for Cancer Research) membership.