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Dr. Sinead Brennan
Clinical Senior Lecturer, Clinical Medicine

Publications and Further Research Outputs

Peer-Reviewed Publications

Lang, P., Contreras, J., Kalman, N., Paterson, C., Bahig, H., Billfalk-Kelly, A., Brennan, S., Rock, K., Read, N., Venkatesan, V., Sathya, J., Mendez, L.C., MacNeil, S.D., Nichols, A.C., Fung, K., Mendez, A., Winquist, E., Kuruvilla, S., Stewart, P., Warner, A., Mitchell, S., Theurer, J.A., Palma, D.A., Preservation of swallowing in resected oral cavity squamous cell carcinoma: Examining radiation volume effects (PRESERVE): Study protocol for a randomized phase II trial, Radiation Oncology, 15, (1), 2020 Journal Article, 2020

Clerkin C, Brennan S, Mullaney LM. , Establishment of national diagnostic reference levels (DRLs) for radiotherapy localisation computer tomography of the head and neck., Reports of Practical Oncology & Radiotherapy, 23, (5), 2018, p407 - 412 Journal Article, 2018 URL

Mehanna H, Robinson M, Hartley A, Kong A, Foran B, Fulton-Lieuw T, Dalby M, Mistry P, Sen M, O'Toole L, Al Booz H, Dyker K, Moleron R, Whitaker S, De-ESCALaTE HPV Trial Group, Radiotherapy plus cisplatin or cetuximab in low-risk human papillomavirus-positive oropharyngeal cancer (De-ESCALaTE HPV): an open-label randomised controlled phase 3 trial., Lancet (London, England), 2018 Journal Article, 2018 URL

H Mehanna, A Kong, A Hartley, P Mistry, M Dalby, T Fulton-Lieuw, M Robinson, A Gray, B Foran, M Sen, L O'Toole, K Dyker, H Al Booz, R Moleron, S Brennan, E Aynsley, A Chan, D Srinivasan, J Buter, J Dunn, Cetuximab versus cisplatin in patients with HPV-positive, low risk oropharyngeal cancer, receiving radical radiotherapy, Annals of Oncology, 29, 2018, p729 - 730 Journal Article, 2018

Keenan LG, O'Sullivan S, Glynn A, Higgins M, Flavin A, Brennan S, Clinical review of treatment outcomes and patterns of failure with adjuvant radiotherapy in node-positive malignant melanoma., Journal of medical imaging and radiation oncology, 2016 Journal Article, 2016 DOI

Fleming C, Cagney DN, O'Keeffe S, Brennan SM, Armstrong JG, McClean B, Normal tissue considerations and dose-volume constraints in the moderately hypofractionated treatment of non-small cell lung cancer., Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2016 Journal Article, 2016 DOI

Rafee S, Elamin YY, Cronin K, Brennan S, Osman N, A rare case of nasopharyngeal carcinoma with widespread CNS metastases., Irish medical journal, 2014 Journal Article, 2014 URL

Osman N, Elamin YY, Rafee S, O'Brien C, Stassen LF, Timon C, Kinsella J, Brennan S, O'Byrne KJ., Weekly cisplatin concurrently with radiotherapy in head and neck squamous cell cancer: a retrospective analysis of a tertiary institute experience, Eur Arch Otorhinolaryngol, 271, (8), 2014, p2253-9 Journal Article, 2014 DOI

Lin MY, Wu M, Brennan S, Campeau MP, Binns DS, MacManus M, Solomon B, Hicks RJ, Fisher RJ, Ball DL, Absence of a relationship between tumor ¹"F-fluorodeoxyglucose standardized uptake value and survival in patients treated with definitive radiotherapy for non-small-cell lung cancer., Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2014 Journal Article, 2014 URL

Gulliford SL, Miah AB, Brennan S, McQuaid D, Clark CH, Partridge M, Harrington KJ, Morden JP, Hall E, Nutting CM, Dosimetric explanations of fatigue in head and neck radiotherapy: an analysis from the PARSPORT Phase III trial., Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2012 Journal Article, 2012 URL

Ahmed M, Schmidt M, Sohaib A, Kong C, Burke K, Richardson C, Usher M, Brennan S, Riddell A, Davies M, Newbold K, Harrington KJ, Nutting CM, The value of magnetic resonance imaging in target volume delineation of base of tongue tumours--a study using flexible surface coils., Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2010 Journal Article, 2010 URL

Gregory DL, Brennan SM, Stillie A, Herschtal A, Hicks RJ, MacManus MP, Ball DL, Impact of 18F-fluorodeoxyglucose positron emission tomography in the staging and treatment response assessment of extra-pulmonary small-cell cancer., Journal of medical imaging and radiation oncology, 2010 Journal Article, 2010 URL

Brennan S, Corry J, Kleid S, Porceddu S, Yuen K, Rischin D, Peters LJ, Prospective trial to evaluate staged neck dissection or elective neck radiotherapy in patients with CT-staged T1-2 N0 squamous cell carcinoma of the oral tongue., Head & neck, 2010 Journal Article, 2010 URL

Brennan SM, Gregory DL, Stillie A, Herschtal A, Mac Manus M, Ball DL, Should extrapulmonary small cell cancer be managed like small cell lung cancer?, Cancer, 2010 Journal Article, 2010 URL

sinead brennan, Reply: Elective Radiotherapy or Neck Dissection for CT‐Staged T1-2N0 Oral Tongue Cancer, head neck, 30, 2010, p1430- Journal Article, 2010

Brennan, S., Elective radiotherapy or neck dissection for CT-Staged T1-2N0 oral tongue cancer, Head and Neck, 32, (10), 2010, p1430 Journal Article, 2010

Brennan SM, Thirion P, Buckney S, Shea CO, Armstrong J, Factors influencing conformity index in radiotherapy for non-small cell lung cancer., Medical dosimetry : official journal of the American Association of Medical Dosimetrists, 2009 Journal Article, 2009 URL

Brennan S, Salib O, O'Shea C, Moriarty M, A randomized prospective study of extended tocopherol and pentoxifylline therapy, in addition to carbogen, in the treatment of radiation late effects., Ecancermedicalscience, 2008 Journal Article, 2008

Glynn F, Brennan S, O'Leary G., CT staging and surveillance of the thorax in patients with newly diagnosed and recurrent squamous cell carcinoma of the head and neck: is it necessary?, Eur Arch Otorhinolaryngol, 263, (10), 2006, p943-945 Journal Article, 2006 DOI

Agha A, Sherlock M, Brennan S, O'Connor SA, O'Sullivan E, Rogers B, Faul C, Rawluk D, Tormey W, Thompson CJ, Hypothalamic-pituitary dysfunction after irradiation of nonpituitary brain tumors in adults., The Journal of clinical endocrinology and metabolism, 2005 Journal Article, 2005 URL

Agha A, Brennan S, Moore KB, Grogan L, Thompson CJ, Small-cell lung cancer presenting as diabetes insipidus and Cushing's syndrome., Pituitary, 2005 Journal Article, 2005 URL

Non-Peer-Reviewed Publications

Head and Neck Radiotherapy Long-Term Toxicity: The Role of Conformal Radiotherapy in, ESTRO Teaching Course on Radiotherapy Treatment Planning: Principles and Practice March 2009, estro, 2009, [. Gillham C, Thirion P, Brennan S, Walsh L] Book Chapter, 2009

Prostate Cancer: Anatomy, Pathology and Treatment in, ESTRO Teaching Course on Radiotherapy Treatment Planning: Principles and Practice March 2009, 2006, [. Rangaswamy G, McVey G, Brennan S, Hacking D, Thirion P] Book Chapter, 2006

Recognition

Representations

Board Member Irish Cancer Society 08/2016

St Lukes Insititute Cancer Research Board Member 2014

Member Cancer Prevention Committee Irish Cancer Society 2017

NCCP -national Cancer Control Program- Head Neck Cancer Clinical Lead 2017

Faculty of Radiology , Radiation Oncology Committee, Royal College of Surgeons in Ireland 2012

St Lukes Research Ethics Committee- Vice Chair 2018

Awards and Honours

Faculty of Radiologists RCSI/ Ipsen Travelling Fellowship, 2009 2009

Research presentation prize and educational bursary - British Thoracic Oncology Group 2008 January 2008

Research presentation prize and educational bursary (ANZHNS 2008 Australia New Zealand Head Neck Society ASM) 2008

Scholarship awarded to National Cancer Institute - - NCI Summer Fellowship Program in Cancer Prevention - Washington DC, July 2007 2007

. National presentation prize and educational bursary (Faculty of Radiology RCSI Annual Meeting 2005) 2005

Title of College Scholar, University College Cork 1995 1995

Irish Womens Awards 2019 - Contribution to Medicine January 2019

Memberships

St Lukes Institute of Cancer Research - Board Member 2013 – present

Irish Cancer Society - Board Member 2014 – present

Cancer Trials Ireland member and Chair of Head Neck Cancer Disease Specific Subgroup ( DSSG) Jan 2009 – present

Head Neck Cancer Intergroup, Irish Representative 2018 – present

Royal college of physicians in Ireland membership 2002

Faculty Of Radiology, Royal College of Surgeons in Ireland 2006 – present

ASTRO - American Society of Therapeutic radiation Oncology July 2007

ESTRO European Society of Therapeutic Radiation Oncology 2006