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Dr. Gareth Brady
Ussher Assistant Professor, Clinical Medicine

Publications and Further Research Outputs

Peer-Reviewed Publications

Dearbhaile Dooley, Mirjan M. van Timmeren, Vincent P. O'Reilly, Gareth Brady, Eoin C. O'Brien, Barbara Fazekas, Fionnuala B. Hickey, Emma Leacy, Charles D. Pusey, Frederick W.K. Tam, Thomas Mehrling, Peter Heeringa and Mark A. Little, Alkylating histone deacetylase inhibitors may have therapeutic value in experimental myeloperoxidase-ANCA vasculitis, Kidney International, 2018 Journal Article, 2018 DOI

Brady, G., Haas, D.A., Farrell, P.F., Pichlmair, A. and Bowie, A.G. , Molluscum Contagiosum Virus protein MC005 inhibits NFκB activation by targeting NEMO-regulated IKK activation, The Journal of Virology, 91, (15), 2017, p00545-17 Journal Article, 2017 DOI TARA - Full Text

Brady G, Hass DA, Pichlmair A, Farrell PJ, and Bowie AG. , Human Poxvirus protein MC132 from Molluscum Contagiosum Virus inhibits NFκB activation by targeting p65 for degradation., Journal of Virology , (89), 2015, p8406-15 Journal Article, 2015

Brady G and Bowie AG , Poxviral inhibitors of NFκB, Cytokine and Growth Factor Reviews, Oct;25(5), 2014, p611-2 Review Article, 2014

Brady G, C.E. Karstegl and P.J. Farrell, Novel function of the unique N terminal region of RUNX1c in B cell growth regulation, Nucleic Acids Research, Feb 1;41(3), 2013, p1555-68 Journal Article, 2013

Brady, G., and Farrell, P. J., RUNX3-mediated repression of RUNX1 in B cells. , Journal of cellular physiology , 221, 2009, p283-2 Review Article, 2009

Brady, G., Whiteman, H. J., Spender, L. C., and Farrell, P. J., Downregulation of RUNX1 by RUNX3 requires the RUNX3 VWRPY sequence and is essential for Epstein-Barr virus-driven B-cell proliferation., Journal of Virology, 83, 2009, p6909 - 6916 Journal Article, 2009

Lucchesi, W., Brady, G., Dittrich-Breiholz, O., Kracht, M., Russ, R., and Farrell, P. J., Differential gene regulation by Epstein-Barr virus type 1 and type 2 EBNA2. , Journal of virology, 82, 2008, p7456 - 7466 Journal Article, 2008

Gubster C, Goodbody R, Ecker A, Brady G, O'Neill LA, Jacobs N, Smith GL., Camelpox virus encodes a schlafen-like protein that affects orthopoxvirus, Journal of General Virology, 88, (6), 2007, p1667-1676 Journal Article, 2007 TARA - Full Text DOI

Brady, G., MacArthur, G. J., and Farrell, P. J., Epstein-Barr virus and Burkitt lymphoma., J Clin Pathol., 60(12):13, 2007, p1397-402 Review Article, 2007

Brady G, Boggan L, Bowie A and O'Neill LA, Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1, Journal of Biological Chemistry, 280, (35), 2005, p30723 - 30734 Journal Article, 2005 TARA - Full Text DOI

Fitzgerald, K. A., Palsson-McDermott, E. M., Bowie, A. G., Jefferies, C. A., Mansell, A. S., Brady, G., Brint, E., Dunne, A., Gray, P., Harte, M. T., McMurray, D., Smith, D. E., Sims, J. E., Bird, T. A., and O'Neill, L. A., Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature 413, 78-83, Nature, 413, 2001, p73 - 83 Journal Article, 2001

C. Jefferies, A. Bowie, G. Brady, E. L. Cooke, X. Li and L. A. O'Neill, Transactivation by the p65 subunit of NF-kappaB in response to interleukin-1 (IL-1) involves MyD88, IL-1 receptor-associated kinase 1, TRAF-6, and Rac1, Molecular and cellular biology, 21, (14), 2001, p4544-52 Journal Article, 2001 TARA - Full Text URL

Non-Peer-Reviewed Publications

Brady, G., Macarthur, G. J., and Farrell, P. J., Epstein-Barr virus and Burkitt lymphoma. , Postgraduate medical Journal, 84, 2008, p372-377 Review Article, 2008

Research Expertise

Projects

  • Title
    • Screening the Molluscum Contagiosum Virus genome for novel immomodulators
  • Summary
    • This Marie Curie IEF Research Training Fellowship project involved screening the Molluscum Contagiosum Virus (MCV) genome for novel immunoregulatory sequences and identified 5 novel immunomodulators and characterised the mechanism of action of four of these proteins.
  • Funding Agency
    • EU
  • Date From
    • 2013
  • Date To
    • 2015
  • Title
    • Novel anti-inflammatory therapeutics derived from a human adapted poxvirus
  • Summary
    • Developing anti-inflammatory peptides derived from viral inhibitors of inflammation and using a variety of inflammatory models like autoimmune vasculitis models as a means to assess their efficacy prior to developing small molecular inhibitors based on these peptides.
  • Funding Agency
    • SFI
  • Date From
    • 2016
  • Date To
    • 2017
  • Title
    • Development of novel monocyte pro-inflammatory expression biomarkers in autoimmune vasculitis and development of novel peptide inhibitors of monocyte-driven inflammation
  • Summary
    • Testing anti-inflammatory peptides derived from viral inhibitors of inflammation and using autoimmune vasculitis models as a means to assess their efficacy prior to developing small molecular inhibitors based on these peptides.
  • Funding Agency
    • Meath Foundation
  • Date From
    • 2017
  • Date To
    • 2018
  • Title
    • Characterisation of Molluscum Contagiosum Virus (MCV)-derived Inhibitors and anti-inflammatory cell permeable peptides (CPPs) in human monocytes.
  • Summary
    • Investigation of inhibitory potential of small peptides derived from MCV as inhibitors of monocyte-driven inflammation
  • Funding Agency
    • Wellcome Trust/School Support
  • Date From
    • 2018
  • Date To
    • 2021

Keywords

INNATE IMMUNITY

Recognition

Awards and Honours

National Irish Times Science writing award 2000

Young Investigator Award International RUNX Conference, Ja Jolla, San Diego 2011

Best Research Prize, Irish Society for Immunology (ISI) meeting 2014

Best Research Presentation Prize NF Kappa B 2014 workshop at Pitlochry. 2014

Roche Gold Medal for Best Researcher. 2015

Best Poster Presentation Prize, Irish Society for Immunology (ISI) meeting 2015

Best Basic Science Presentation, Irish Nephrology Society meeting 2018

Memberships

Biochemical Society 2000 – Present

Irish Society of Immunology 2013 – Present