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Dr. Martin Barr
Clinical Senior Lecturer, Clinical Medicine
Clinical Senior Lecturer, Molecular Medicine Ireland

Publications and Further Research Outputs

Peer-Reviewed Publications

Flynn L*, Barr MP*, Baird AM*, Smyth P, Casey OM, Blackshields G, Greene J, Pennington SR, Hams E, Fallon PG, O'Leary JJ, Sheils O, Finn SP. , Prostate cancer-derived holoclones: a novel and effective model for evaluating cancer stemness., Scientific Reports, 2020 Journal Article, 2020

Ryan, S.-L. and Beard, S. and Barr, M.P. and Umezawa, K. and Heavey, S. and Godwin, P. and Gray, S.G. and Cormican, D. and Finn, S.P. and Gately, K.A. and Davies, A.M. and Thompson, E.W. and Richard, D.J. and O'Byrne, K.J. and Adams, M.N. and Baird, A.-M., Targeting NF-κB-mediated inflammatory pathways in cisplatin-resistant NSCLC, Lung Cancer, 135, 2019, p217-227 Journal Article, 2019 DOI

Martin P. Barr, Patient-oriented Biobanking for Cancer Research, Cancer Studies & Therapeutics, 4, (3), 2019, p1 - 2 Journal Article, 2019

Baird AM, Easty D, Jarzabek M, Shiels L, Soltermann A, Klebe S, Raeppel S, MacDonagh L, Wu C, Griggs K, Kirschner MB, Stanfill B, Nonaka D, Goparaju CM, Murer B, Fennell DA, O'Donnell DM, Barr MP, Mutti L, Reid G, Finn S, Cuffe S, Pass HI, Opitz I, Byrne AT, O'Byrne KJ, Gray SG., When RON MET TAM in Mesothelioma: All Druggable for One, and One Drug for All?, Frontiers in endocrinology, 10, 2019, p89 Journal Article, 2019 DOI

MacDonagh L, Gray SG, Breen E, Cuffe S, Finn SP, O'Byrne KJ, Barr MP, Exploitation of the vitamin A/retinoic acid axis depletes ALDH1-positive cancer stem cells and re-sensitizes resistant non-small cell lung cancer cells to cisplatin, Molecular Cancer Research, 2018 Journal Article, 2018

Ye T, Jiang K, Wei L, Barr MP, Xu Q, Zhang G, Ding C, Meng S, Piao H., Oncolytic Newcastle disease virus induces autophagy-dependent immunogenic cell death in lung cancer cells., American journal of cancer research, 8, (8), 2018, p1514-1527 Journal Article, 2018 DOI

Heavey S, Dowling P, Moore G, Barr MP, Kelly N, Maher SG, Cuffe S, Finn SP, O'Byrne KJ, Gately K., Development and characterisation of a panel of phosphatidylinositide 3-kinase - mammalian target of rapamycin inhibitor resistant lung cancer cell lines., Scientific Reports, 8, (1), 2018, p1652- Journal Article, 2018 DOI TARA - Full Text

Liu M, Jiang K, Lin G, Liu P, Yan Y, Ye T, Yao G, Barr MP, Liang D, Wang Y, Gong P, Meng S, Piao H., Ajuba inhibits hepatocellular carcinoma cell growth via targeting of ß-catenin and YAP signaling and is regulated by E3 ligase Hakai through neddylation., Journal of experimental & clinical cancer research : CR, 37, (1), 2018, p165 Journal Article, 2018 DOI

Jiang K, Song C, Kong L, Hu L, Lin G, Ye T, Yao G, Wang Y, Chen H, Cheng W, Barr MP, Liu Q, Zhang G, Ding C, Meng S., Recombinant oncolytic Newcastle disease virus displays antitumor activities in anaplastic thyroid cancer cells., BMC Cancer, 18, (1), 2018, p746 Journal Article, 2018 DOI

MacDonagh, L. and Gray, S.G. and Breen, E. and Cuffe, S. and Finn, S.P. and O'Byrne, K.J. and Barr, M.P., BBI608 inhibits cancer stemness and reverses cisplatin resistance in NSCLC, Cancer Letters, 428, 2018, p117-126 Journal Article, 2018 DOI

Circu M, Cardelli J, Barr M, O'Byrne K, Mills G, El-Osta H., Modulating lysosomal function through lysosome membrane permeabilization or autophagy suppression restores sensitivity to cisplatin in refractory non-small-cell lung cancer cells., PLoS One, 12, (9), 2017, pe0184922- Journal Article, 2017 DOI TARA - Full Text

Knopf KM, Murphy BL, MacMillan SN, Baskin JM, Barr MP, Boros E, Wilson JJ., In Vitro Anticancer Activity and in Vivo Biodistribution of Rhenium(I) Tricarbonyl Aqua Complexes., Journal of the American Chemistry Society, 139, (40), 2017, p14302 - 14314 Journal Article, 2017

MacDonagh Lauren, Gallagher Michael F, Ffrench Brendan, Gasch Claudia, Breen Eamon, Gray Steven G, Nicholson Siobhan, Leonard Niamh, Ryan Ronan, Young Vincent, O'Leary John J, Cuffe Sinead, Finn Stephen P, O'Byrne Kenneth J, Barr Martin P, Targeting the cancer stem cell marker, aldehyde dehydrogenase 1, to circumvent cisplatin resistance in NSCLC , Oncotarget , 8 , (42 ), 2017, p72544 - 72563 Journal Article, 2017 URL DOI

Yan Y, Jiang K, Liu P, Zhang X, Dong X, Gao J, Liu Q, Barr MP, Zhang Q, Hou X, Meng S, Gong P., Bafilomycin A1 induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways., Scientific Reports, 6, 2016, p37052- Journal Article, 2016

Leon, G., MacDonagh, L., Finn, S.P., Cuffe, S., Barr, M.P., Cancer stem cells in drug resistant lung cancer: Targeting cell surface markers and signaling pathways, Pharmacology and Therapeutics, 158, 2016, p71 - 90 Journal Article, 2016

MacDonagh L, Gray SG, Breen E, Cuffe S, Finn SP, O'Byrne KJ, Barr MP, Lung cancer stem cells: The root of resistance., Cancer letters, 372, (2), 2016, p147-56 Journal Article, 2016 DOI

Cregan S, McDonagh L, Gao Y, Barr MP, O'Byrne KJ, Finn SP, Cuffe S, Gray SG, KAT5 (Tip60) is a potential therapeutic target in malignant pleural mesothelioma., International journal of oncology, 48, (3), 2016, p1290-6 Journal Article, 2016 DOI

Barr MP, O'Byrne KJ, Al-Sarraf N, Gray SG., VEGF-mediated cell survival in non-small-cell lung cancer: implications for epigenetic targeting of VEGF receptors as a therapeutic approach., Epigenomics, 7, (6), 2015, p897 - 910 Journal Article, 2015

Barr MP, Gray SG, Gately K, Hams E, Fallon PG, Davies AM, Richard DJ, Pidgeon GP, O'Byrne KJ., Vascular endothelial growth factor is an autocrine growth factor, signaling through neuropilin-1 in non-small cell lung cancer., Molecular Cancer, 14, 2015, p45- Journal Article, 2015

Barr MP, Gray SG, Gately K, Hams E, Fallon PG, Davies AM, Richard DJ, Pidgeon GP, O'Byrne., VEGF is an autocrine growth factor, signalling through Neuropilin-1 in non-small cell lung cancer, Molecular Cancer, In Press, (In Press), 2015 Journal Article, 2015

Dowling P, Pollard D, Larkin A, Henry M, Meleady P, Gately K, O'Byrne K, Barr MP, Lynch V, Ballot J, Crown J, Moriarty M, O'Brien E, Morgan R, Clynes M., Abnormal levels of heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) in tumour tissue and blood samples from patients diagnosed with lung cancer., Molecular Biosystems, 11, (3), 2015, p743 - 752 Journal Article, 2015

Barr MP, O'Byrne KJ, Al-Sarraf N, Gray SG., VEGF-mediated cell survival in NSCLC: Implications for epigenetic targeting of VEGF receptors as a therapeutic approach, Epigenomics, 2015 Journal Article, 2015

Hu L, Sun S, Wang T, Li Y, Jiang K, Lin G, Ma Y, Barr MP, Song F, Zhang G, Meng S., Oncolytic newcastle disease virus triggers cell death of lung cancer spheroids and is enhanced by pharmacological inhibition of autophagy., American Journal of Cancer Research, 5, (12), 2015, p3612 - 3623 Journal Article, 2015

MacDonagh L, Gray SG, Cuffe S, Finn SP, O'Byrne KJ, Barr MP, The emerging role of microRNAs in resistance to lung cancer treatments, Cancer Treatment Reviews, 41, (2), 2015, p160 - 169 Review Article, 2015 URL

MacDonagh,Lauren , Gray,Steven George, Finn,Stephen P. , Cuffe,Sinead D. , O'Byrne,Kenneth John, Barr,Martin P. , The emerging role of microRNAs in resistance to lung cancer treatments, Cancer Treatment Reviews, 41, (2), 2015, p160-169 Journal Article, 2015 DOI

Barr M, Souan L, MacGabhann P, Muller J, Al-Ashhab M, Jasser M, Hamza K, Al-Hassoon S, Kuhn U, Infante D, Lawlor D, Kately K, Amireh E, O'Byrne K, Sughayer MA., The establishment of an ISO compliant cancer biobank for Jordan and its neighboring countries through knowledge transfer and training., Biopreservation and biobanking, 12, (1), 2014, p3-12 Journal Article, 2014 TARA - Full Text DOI

Heavey S, Godwin P, Baird AM, Barr MP, Umezawa K, Cuffe S, Finn S, O'Byrne K, Gately K., Strategic targeting of the PI3K-NFkB axis in cisplatin resistant NSCLC, Cancer Biology & Therapy, 15, (10), 2014, p1367 - 1377 Journal Article, 2014 URL

Dowling P, Pollard D, Larkin AM, Michael H, Meleady P, Gately K, O'Byrne K, Barr MP, Lynch V, Ballot J, Crown J, Moriarity M, O'Brien E, Morgan R, Clynes M. , Abnormal levels of heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) in tumour tissue and blood samples from patients diagnosed with lung cancer , Molecular Biosystems, 2014 Journal Article, 2014 URL

O'Grady S, Finn SP, Cuffe S, Richard DJ, O'Byrne KJ, Barr MP., The role of DNA repair pathways in cisplatin resistant lung cancer, Cancer Treatment Reviews, 40, (10), 2014, p1161 - 1170 Review Article, 2014 URL

Godwin P, Baird AM, Heavey S, Barr MP, O'Byrne KJ, Gately K., Targeting nuclear factor-kappa B to overcome resistance to chemotherapy., Frontiers in oncology, 3, 2013, p120 Journal Article, 2013 TARA - Full Text DOI

Barr MP, Gray SG, Hoffmann AC, Hilger RA, Thomale J, O'Flaherty JD, Fennell DA, Richard D, O'Leary JJ, O'Byrne KJ., Generation and characterisation of Cisplatin-resistant non-small cell lung cancer cell lines displaying a stem-like signature., PloS one, 8, (1), 2013, pe54193 Journal Article, 2013 DOI TARA - Full Text URL

Gao Y, Baird AM, Barr MP, Gately K, O'Byrne KJ, Gray SG., Epigenetic therapy for cisplatin resistance in non-small cell lung cancer: the way forward?, Lung Cancer Management, 2, (1), 2013, p1 - 4 Review Article, 2013

Barr MP, MacDonagh L, O'Byrne KJ., Markers of response to platinum-based chemotherapy in lung cancer, Lung Cancer Management, 2, (3), 2013, p1 - 13 Review Article, 2013

Molecular Mechanisms of Cisplatin Resistance in Lung Cancer. in, editor(s)Gately, KA , Lung Cancer: A Comprehensive Overview. , New York, Nova Science Publishers, 2013, pp171 - 190, [Martin P Barr] Book Chapter, 2013

O'Flathery JD, Barr M, Fennell D, Richard D, Reynolds J, O'Leary J, O'Byrne K., The Cancer Stem-Cell Hypothesis: Its Emerging Role in Lung Cancer Biology and its Relevance for Future Therapy, Journal of Thoracic Oncology, 7, (12), 2012, p1880 - 1890 Review Article, 2012 URL

KJ O'Byrne, The Role of Epigenetics in Resistance to Cisplatin Chemotherapy in Lung Cancer, Cancers , 3, (1), 2011, p1426-1453 Journal Article, 2011 TARA - Full Text

O'Byrne KJ, Barr MP, Gray SG., The role of epigenetics in resistance to cisplatin chemotherapy in lung cancer, Cancers, 3, (1), 2011, p1426 - 1453 Journal Article, 2011 TARA - Full Text

Field JK, Liloglou T, Niaz A, Bryan J, Gosney JR, Giles T, Brambilla C, Brambilla E, Vesin A, Timsit JF, Hainaut P, Martinet Y, Vignaud JM, Thunnissen FB, Prinsen C, Snijders PJ, Smit EF, Sozzi G, Roz L, Risch A, Becker HD, Elborn JS, Magee ND, Montuenga LM, Pajares MJ, Lozano MD, O'Byrne KJ, Harrison DJ, Niklinski J, Cassidy A, EUELC project: a multi-centre, multipurpose study to investigate early stage NSCLC, and to establish a biobank for ongoing collaboration., The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology, 34, (6), 2009, p1477-86 Journal Article, 2009 DOI

Barr MP, Bouchier-Hayes DJ, Harmey JJ., Vascular endothelial growth factor is an autocrine survival factor for breast tumour cells under hypoxia., International Journal of Oncology, 32, (1), 2008, p41 - 48 Journal Article, 2008

Barr MP, Byrne AM, Duffy AM, Condron CM, Devocelle M, Harriott P, Bouchier-Hayes DJ, Harmey JH., A peptide corresponding to the neuropilin-1-binding site on VEGF(165) induces apoptosis of neuropilin-1-expressing breast tumour cells., British Journal of Cancer, 92, (2), 2005, p328 - 333 Journal Article, 2005

Pidgeon GP, Barr MP, Harmey JH, Foley DA, Bouchier-Hayes DJ., Vascular endothelial growth factor (VEGF) upregulates BCL-2 and inhibits apoptosis in human and murine mammary adenocarcinoma cells., British Journal of Cancer, 85, (2), 2001, p273 - 278 Journal Article, 2001

Research Expertise

Keywords

Anticancer therapies; Apoptosis and cancer; Cancer Biology; Cancer chemotherapeutic drugs- mode of action; Cancer genetics and cell biology including metastasis; Cancer Stemness; CANCER-CELLS; Lung Cancer; Non-small cell lung cancer

Recognition

Memberships

Member of the Irish Association for Cancer Research (IACR).

Member & Ambassador of the European Association for Cancer Research (EACR).

Member of the International Association for the Study of Lung Cancer (IASLC).

Member (Associate) of the European Society for Medical Oncology (ESMO).

Member of the Irish Thoracic Society (ITS).

Member of the European Respiratory Society (ERS).

Fellow of the Institute of Biomedical Science UK (IBMS).

Chartered Scientist (Science Council, UK).

Member of the Irish Platform for Patients' Organisations, Science and Industry (IPPOSI).

Member of the Health Research Board-Clinical Research Coordination Ireland (HRB-CRCI).

Member of the Academy of Clinical Science & Laboratory Medicine (ACSLM).