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Dr. Aisling Dunne
Associate Prof in Neuroinflammation, Biochemistry
Associate Prof in Neuroinflammation, Physiology

Publications and Further Research Outputs

Peer-Reviewed Publications

Olwyn R. Mahon, David C. Brow, Tomas Gonzalez-Fernandez, Pierluca Pitaccoc, Ian T. Whelan, Stanislas Von E, Christopher Hobbs, Valeria Nicolosi, Kyle T. Cunningham, Kingston. H. G. Mills , Daniel J. Kelly and Aisling Dunne, Nano-particle mediated M2 macrophage polarization enhances bone formation and MSC osteogenesis in an IL-10 dependent manner, Biomaterials, 239, 2020, p119833- Journal Article, 2020 DOI TARA - Full Text

Cunniffe GM, Díaz-Payno PJ, Sheehy EJ, Critchley SE, Almeida HV, Pitacco P, Carroll SF, Mahon OR, Dunne A, Levingstone TJ, Moran CJ, Brady RT, O'Brien FJ, Brama PAJ, Kelly DJ, Tissue-specific extracellular matrix scaffolds for the regeneration of spatially complex musculoskeletal tissues, Biomaterials. , 188, 2019, p63-73 Journal Article, 2019 DOI TARA - Full Text

Browe, D.C. and Mahon, O.R. and Díaz-Payno, P.J. and Cassidy, N. and Dudurych, I. and Dunne, A. and Buckley, C.T. and Kelly, D.J., Glyoxal cross-linking of solubilized extracellular matrix to produce highly porous, elastic, and chondro-permissive scaffolds for orthopedic tissue engineering, Journal of Biomedical Materials Research - Part A, 2019 Journal Article, 2019 DOI TARA - Full Text

Silveira, A.A.A. and Mahon, O.R. and Cunningham, C.C. and Corr, E.M. and Mendonça, R. and Saad, S.T.O. and Costa, F.F. and Dunne, A. and Conran, N., S100A8 acts as an autocrine priming signal for heme-induced human MÏ. pro-inflammatory responses in hemolytic inflammation, Journal of Leukocyte Biology, 106, (1), 2019, p35-43 Journal Article, 2019 DOI

Campbell, N.K. and Fitzgerald, H.K. and Fletcher, J.M. and Dunne, A., Plant-derived polyphenols modulate human dendritic cell metabolism and immune function via AMPK-dependent induction of heme oxygenase-1, Frontiers in Immunology, 10, (MAR), 2019, p00345- Journal Article, 2019 TARA - Full Text DOI

Nazmi, A., Field, R.H., Griffin, E.W., Haugh, O., Hennessy, E., Cox, D., Reis, R., Tortorelli, L., Murray, C.L., Lopez-Rodriguez, A.B., Lavelle, E.C., Dunne, A. and Cunningham,C. , Chronic neurodegeneration induces Type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression, Glia, 67, 2019, p1254 - 1276 Journal Article, 2019 DOI TARA - Full Text

Díaz-Payno, P., Cunniffe G.M., Sheehy, E.J., Critchley, S., Almeida, H., Pitacco, P., Carroll, S., Mahon, O., Dunne, A., Levingstone, T., Moran, C., Brady, R., O'Brien, F.J., Brama, P. and Kelly, D.J., Layering of tissue-specific extracellular matrix scaffolds for the regeneration of spatially complex musculoskeletal tissues, Biomaterials, 188, 2019, p63 - 73 Journal Article, 2019

Mahon, O.R. and O'Hanlon, S. and Cunningham, C.C. and McCarthy, G.M. and Hobbs, C. and Nicolosi, V. and Kelly, D.J. and Dunne, A., Orthopaedic implant materials drive M1 macrophage polarization in a spleen tyrosine kinase- and mitogen-activated protein kinase-dependent manner, Acta Biomaterialia, 65, 2018, p426-435 Journal Article, 2018 DOI

Cunningham, C. and Dunne, A. and Lopez-Rodriguez, A.B., Astrocytes: Heterogeneous and Dynamic Phenotypes in Neurodegeneration and Innate Immunity, Neuroscientist, 2018 Journal Article, 2018 DOI TARA - Full Text

Lopez Rodriguez A., Dunne, A. and Cunningham, C, Heterogeneous and Dynamic Astrocyte phenotypes in neurodegeneration and innate immunity, The Neuroscientist, 2018, pdoi:10.1177/1073858418809941 Review, 2018 URL

Mahon, O.R. and Dunne, A., Disease associated particulates and joint inflammation; mechanistic insights and therapeutic targets, Frontiers in Immunology, 9, 2018 Review, 2018 URL TARA - Full Text

McCarthy, G.M. and Dunne, A., Calcium Crystal Deposition Diseases - beyond gout, Nature Reviews Rheumatology, 14, 2018 Review, 2018 URL

Campbell, N.K. and Fitzgerald, H.K. and Malara, A. and Hambly, R. and Sweeney, C.M. and Kirby, B. and Fletcher, J.M. and Dunne, A., Naturally derived Heme-Oxygenase 1 inducers attenuate inflammatory responses in human dendritic cells and T cells: Relevance for psoriasis treatment, Scientific Reports, 8, (1), 2018, p10287 - Journal Article, 2018 DOI TARA - Full Text

Corr E.M, Cunningham C.C, Helbert L, McCarthy G.M, Dunne A, Osteoarthritis-associated basic calcium phosphate crystals activate membrane proximal kinases in human innate immune cells, Arthritis Research and Therapy, 19, (1), 2017, p23- Journal Article, 2017 DOI TARA - Full Text URL

Cunniffe G.M, Díaz-Payno P.J, Ramey J.S, Mahon O.R, Dunne A, Thompson E.M, O'Brien F.J, Kelly D.J, Growth plate extracellular matrix-derived scaffolds for large bone defect healing, European Cells and Materials, 33, 2017, p130 - 142 Journal Article, 2017 TARA - Full Text URL DOI

Corr E.M, Cunningham C.C, Dunne A, Cholesterol crystals activate Syk and PI3 kinase in human macrophages and dendritic cells, Atherosclerosis, 251, 2016, p197 - 205 Journal Article, 2016 URL DOI

Cunningham, C., Corr, E., McCarthy, G., Dunne, A, Phenotypic and Functional Characteristics of Exosomes Isolated from Human Osteoarthritis (OA) Synovial Fluid. , Arthritis Rheumatol. , 2016 ACR/ACHP Annual Meeting, Washington, 68 (suppl 10)., 2016 Conference Paper, 2016

Cunningham, C., Corr, E.M., McCarthy, G.M. and Dunne A, Intra-articular Basic Calcium Phosphate and Monosodium Urate Crystals Inhibit anti-osteoclastogenic Cytokine Signalling, Osteoarthritis and Cartilage, 24, 2016, p2141 - 2152 Journal Article, 2016 TARA - Full Text URL

Basdeo S.A, Campbell N.K, Sullivan L.M, Flood B, Creagh E.M, Mantle T.J, Fletcher J.M, Dunne A, Suppression of human alloreactive T cells by linear tetrapyrroles; relevance for transplantation, Translational Research, 178, 2016, p81-94.e2 Journal Article, 2016 URL DOI TARA - Full Text

Investigating inflammasome activation under conditions of cellular stress and injury in, Stress Responses: Methods and Protocols, 2015, pp105-113 , [Cunningham C.C, Corr E.M, Cox D.J, Dunne A] Book Chapter, 2015 DOI URL

Cox, D. J., Field, R. H., Williams, D. G., Baran, M., Bowie, A. G., Cunningham, C. and Dunne, A. , DNA sensors are expressed in astrocytes and microglia in vitro and are upregulated during gliosis in neurodegenerative disease, GLIA, 63, (5), 2015, p812-825 Journal Article, 2015 TARA - Full Text DOI

McCarthy, G., Cunningham, C., Corr, E., Dunne, A., Calcium Hydroxyapatite Crystals Inhibit Interleukin-6- and Interferon-γ -induced Anti-Osteoclastogenic Signaling in human osteoclast precursors. , Arthritis Rheumatol. , 2015 ACR/ACHP Annual Meeting, San Francisco, 2015, 67 (suppl 10), 2015 Conference Paper, 2015

Dunne A, Mielke LA, Allen AC, Sutton CE, Higgs R, Cunningham CC, Higgins SC, Mills KH, A novel TLR2 agonist from Bordetella pertussis is a potent adjuvant that promotes protective immunity with an acellular pertussis vaccine., Mucosal immunology, 8, (3), 2015, p607-617 Journal Article, 2015 DOI

Aisling Dunne and Kingston Mills, 'TLR2 agonists and vaccines and uses thereof', European Patent Office, WO/2015/140234, 2015 Patent, 2015 URL

Wochal, P., Rathinam, V.A.K., Dunne, A., (...), Fitzgerald, K.A., O'Neill, L.A.J. , TRIL is involved in cytokine production in the brain following escherichia coli infection, Journal of Immunology, 193, (4), 2014, p1911-1919 Journal Article, 2014 DOI TARA - Full Text

Activating the NLRP3 inflammasome using the amyloidogenic peptide IAPP in, 2013, pp9-18 , [Westwell-Roper, C., Dunne, A., Kim, M.L., Verchere, C.B., Masters, S.L.] Book Chapter, 2013 DOI

Franklin, E., Mantle, T., Dunne, A., Activation of human biliverdin-IXα reductase by urea: Generation of kinetically distinct forms during the unfolding pathway, Biochimica et Biophysica Acta - Proteins and Proteomics, 1834, (12), 2013, p2573-2578 Journal Article, 2013 DOI

Miggin, S.M., Pålsson-McDermott, E., Dunne, A., Jefferies, C., Pinteaux, E., Banahan, K., Murphy, C., Moynagh, P., Yamamoto, M., Akira, S., Rothwell, N., Golenbock, D., Fitzgerald, K.A., O'Neill, L.A.J., Erratum: NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1 (Proceedings of the National Academy of Sciences of the United States of America (2007) 110 (3372-3377) DOI: 10.1073/pnas.0608100104), Proceedings of the National Academy of Sciences of the United States of America, 110, (43), 2013, p17600 Journal Article, 2013 DOI

Cunningham CC, Mills E, Mielke LA, O'Farrell LK, Lavelle E, Mori A, McCarthy GM, Mills KH, Dunne A, Osteoarthritis-associated basic calcium phosphate crystals induce pro-inflammatory cytokines and damage-associated molecules via activation of Syk and PI3 kinase., Clinical immunology (Orlando, Fla.), 144, (3), 2012, p228-236 Journal Article, 2012 DOI

McCarthy, G., Mills, E., Mill, K, Dunne, A., Osteoarthritis-Associated Basic Calcium Phosphate Crystals Induce IL-1, IL-18 and S100A8 Production in A Tyrosine Kinase Dependent Manner. , Arthritis Rheumatol. , 2012 ACR/ACHP Annual Meeting, Atlanta, 2012, 2012 Conference Paper, 2012

Carpenter S, Wochal P, Dunne A, O'Neill LA, Toll-like receptor (TLR) 3 signaling requires the TLR4 interactor with leucine-rich repeats (TRIL)., The Journal of Biological Chemistry, 286, (44), 2011, p38795-38804 Journal Article, 2011 TARA - Full Text DOI

Dunne A, Marshall NA, Mills KH, TLR based therapeutics., Current opinion in pharmacology, 11, (4), 2011, p404-11 Review, 2011 DOI

Aisling Dunne, Neil Marshall, Kingston Mills, Targeting Toll-like receptors, by Dunne, A., Marshall N.M. and Mills, K.H. , Current Opinion Pharmacology, 11, 2011, p404-11 Review, 2011

Aisling Dunne, Inflammasome activation: from inflammatory disease to infection, Biochemical Society Transactions, 39, 2011 Review, 2011 TARA - Full Text

Masters, S.L., Dunne, A., Subramanian, S.L., Hull, R.L., Tannahill, G.M., Sharp, F.A., Becker, C., Lavelle,E.C. and O'Neill, L.A.J., Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β 2 in type 2 diabetes , Nature Immunology, 11, (10), 2010, p897-904 Journal Article, 2010 DOI

Dunne A, Ross PJ, Pospisilova E, Masin J, Meaney A, Sutton CE, Iwakura Y, Tschopp J, Sebo P, Mills KH, Inflammasome activation by adenylate cyclase toxin directs Th17 responses and protection against Bordetella pertussis., Journal of Immunology , 185, (3), 2010, p1711-9 Journal Article, 2010 DOI URL TARA - Full Text

Susan Carpenter, Aisling Dunne, Pearl Gray, Constantinos Brikos, Astrid Strelow, Holger Wesche, Nick Morrice and Luke A.J. O'Neill. , IRAK1 AND IRAK4 promote phosphorylation, Ubiquitination and degradation of MyD88 adapter-like (MAL)., Journal of Biological Chemistry, 285, (24), 2010, p18276-18282 Journal Article, 2010 DOI

Carpenter S, Carlson T, Dellacasagrande J, Garcia A, Gibbons S, Hertzog P, Lyons A, Lin LL, Lynch M, Monie T, Murphy C, Seidl KJ, Wells C, Dunne A, O'Neill LA. , TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain., Journal of Immunology, 183, (6), 2009, p3989-3995 Journal Article, 2009 DOI

Mills KH, Dunne A, Immune modulation: IL-1, master mediator or initiator of inflammation, Nature Medicine, 15, (12), 2009, p1363-1364 Review, 2009 TARA - Full Text DOI

Khor, CC, Chapman, SJ, Vannberg, FO, Dunne A, Murphy C, Ling EY, Frodsham AJ, Walley, A, Kyrieleis, O, Khan, A, Aucan, C, Segal, S, Moore, CE, Know, K, Campbell, SJ, Lienhardt, C, Scott, A, Aaby, P, Sow, OY, Grignani, RT, Peshu, N, Williams, TN, Maitland, K, Davies, RJO, Kwiatkowski, DP, Day, NP, Yala, D, Crook, DW, Marsh, K, Berkley, JA, O'Neill LAJ* and Hill, AVS*, A functional variant in MAL/TIRAP and protection against invasive pneumococcal disease, bacteraemia, malaria and tuberculosis, Nature Genetics, 39, (4), 2007, p523 - 528 Journal Article, 2007 TARA - Full Text DOI

Edward Franklin, Seamus Browne, Jerrard Hayes, Coilin Boland, Aisling Dunne, Gordon Elliot, and Timothy J. Mantle, Activation of biliverdin-IXα reductase by inorganic phosphate and related anions, Biochemical Journal, 405, 2007, p61-67 Journal Article, 2007 TARA - Full Text

Miggin SM, Palsson-McDermott E, Dunne A, Jefferies, CA, Pinteaux, E, Banahan, K, Murphy C, Moynagh PN, Yamamoto, S, Akira S, Rothwell N, Golenbock, DT, Fitzgerald KA and O'Neill LA, NF-kappaB activation by the Toll-IL-1 receptor domain-containing protein Mal is regulated by caspase-1, Proceedings of the National Academy of Sciences , 104, 2007, p3372 - 3377 Journal Article, 2007 TARA - Full Text DOI

Pearl Gray, Aisling Dunne, Constantinos Brikos, Caroline A. Jefferies, Sarah L. Doyle, and Luke A. J. O'Neill, MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction, Journal of Biological Chemistry, 281, (15), 2006, p10489 - 10495 Journal Article, 2006 DOI TARA - Full Text

Dunne A and O'Neill L, New insights into the post-translational modification of Toll-like receptor, Journal of Endotoxin Research, 11, (6), 2005, p325 - 332 Journal Article, 2005 URL DOI

Dunne A and O'Neill LA, Adaptor usage and Toll-like receptor signaling specificity, FEBS Lett., 579, (15), 2005 Review, 2005 DOI URL

E. K. Brint, D. Xu, H. Liu, A. Dunne, A. N. McKenzie, L. A. O'Neill and F. Y. Liew, ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance, Nature immunology, 5, (4), 2004, p373-379 Journal Article, 2004 DOI URL URL

A. Dunne and L. A. O'Neill, The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense, Science's STKE [electronic resource], 2003, (171), 2003, pre3 Review, 2003 DOI URL URL

A. Dunne, M. Ejdeback, P. L. Ludidi, L. A. O'Neill and N. J. Gay, Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88, The Journal of Biological Chemistry, 278, (42), 2003, p41443-41451 Journal Article, 2003 DOI TARA - Full Text

Jefferies CA, Doyle S, Brunner C, Dunne A, Brint E, Wietek C, Walch E, Wirth T, O'Neill LA, Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4., The Journal of biological chemistry, 278, (28), 2003, p26258-64 Journal Article, 2003 DOI

L. A. O'Neill, A. Dunne, M. Edjeback, P. Gray, C. Jefferies and C. Wietek, Mal and MyD88: adapter proteins involved in signal transduction by Toll-like receptors, Journal of Endotoxin Research, 9, (1), 2003, p55-9 Journal Article, 2003 URL DOI URL

K. A. Fitzgerald, E. M. Palsson-McDermott, A. G. Bowie, C. A. Jefferies, A. S. Mansell, G. Brady, E. Brint, A. Dunne, P. Gray, M. T. Harte, D. McMurray, D. E. Smith, J. E. Sims, T. A. Bird and L. A. O'Neill, Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction, Nature, 413, (6851), 2001, p78-83 Journal Article, 2001 URL URL DOI

Aisling Dunne, Orla Cunningham, Timothy Mantle, Studies on the specificity of the tetrapyrrole substrate for human biliverdin-IXalpha reductase and biliverdin-IXbeta reductase. Structure-activity relationships define models for both active sites, Journal of Biological chemistry, 275, 2000, p19009- Journal Article, 2000

Research Expertise

Description

In recent decades, much has been revealed about the nature of the host innate immune response to microorganisms, with the identification of pattern recognition receptors (PRRs) and pathogen-associated molecular patterns (PAMPs), which are conserved microbial structures sensed by these receptors. It is now apparent that these same PRRs can also be activated by non-microbial signals, many of which are considered as damage-associated molecular patterns (DAMPs). The sterile inflammation that ensues either resolves the initial insult or leads to disease. A key focus of my research has been to identify the mechanisms via which PAMPs and DAMPs activate specific host immune responses and to identify new strategies to treat inflammatory disease. Our work to date on novel PAMPs, for example from Bordetella pertussis (the causative agent of whooping cough), has implications for vaccine design. We have identified a vaccine candidate that acts both as an adjuvant (to boost innate immune responses) and as an antigen (to target the adaptive immune system). Antigens containing both of these properties have never before been described for B.pertussis. This work has been patent protected and we are taking steps to commercialise the products of this research. My work in the field of sterile inflammation has focused on DAMPs that are implicated in osteoarthritis (OA), atherosclerosis and neurodegenerative disease. In particular, my group has carried out a significant amount of work delineating the molecular and inflammatory pathways driven by OA disease-associated particulates. We have identified potential new therapeutic targets to treat OA-associated inflammation and have now extended our work to assess immune responses to orthopedic implant materials which can cause a form of sterile inflammation known as periprosthetic osteolysis. Furthermore, we are collaborating extensively with the Trinity Centre for Engineering and AMBER to assess immune responses to novel biomaterials which are intended to replace traditional biomaterials.

Recognition

Representations

External PhD Examiner - NUI Maynooth 2015

External PhD Examiner - NUI Maynooth 2014

External PhD Examiner - University of Cambridge 2013

Awards and Honours

Trinity Innovation Awards 2018: 'Inventors' Category Nominee. This category recognized academics whose innovative research has led to commercial success. Dec 2018

Memberships

Standing Committee Member: Irish Society of Immunology 2018 – present

British Society of Immunology Member 2011