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Dr. Feras Abu Saadeh
Clinical Senior Lecturer, Obstetrics

Biography

Feras obtained his medical degree (MB ChB) in Sebha Medical University in 2000. He then completed 5 years of post graduate training in obstetrics and gynaecology in Maqased Hospital, Jerusalem, before arriving in Ireland in 2005.

Since 2006 he is a member of the Royal College of Obstetrician and Gynaecologist (UK), Royal College of Physician (Ireland) and member of the British Society of Colposcopy and Cervical Pathology (BSCCP). In 2008, he was appointed as lecturer at Cork University Maternity Hospital where he played a significant role in undergraduate teaching and was involved in the establishment and first year of operation of the first Robotic theatre in the country. Feras joined St. James's hospital in 2009 and was instrumental in transforming the gynaecology services from open traditional surgery to minimal access surgery.

His research lab located in the Institute of Molecular Medicine/ Trinity College focus on biomarker for ovarian cancer and cancer associated thrombosis. His research was published in international peer reviewed journals. Feras has an MD from Trinity College Dublin and he is an RCOG accredited subspecialist in Gynaecology Oncology. Since 2013, he is working as a Consultant Gynaecological Oncologist at St. James's hospital, Dublin and is a senior clinical lecturer for Trinity College Dublin.

Publications and Further Research Outputs

Peer-Reviewed Publications

LA Norris, F Abu Saadeh, M Ward, SA O'Toole, Z Marchocki, N. Ibrahim, N Gleeson, Development and validation of a risk model for prediction of venous thromboembolism in gynaecological cancer patients, Thrombosis Research, International Congress on Thrombosis and Haemostasis Issues in Cancer, Bergamo, April 2018, 164, (Supplement 1), Elsevier, 2018, ppS183 - S184 Oral Presentation, 2018 DOI

Z. Marchocki, L.N. Norris, S.A. O'Toole, N. Gleeson, F. Abu Saadeh S235, Patients experience and compliance with extended LMWH prophylaxis post-surgery for gynaecological cancer, Thrombosis Research, International Congress on Thrombosis and Haemostasis Issues in Cancer, Bergamo, April 2018, 164, (Supplement 1), Elsevier, 2018, ppS235 - S235 Published Abstract, 2018 DOI

Ward MP, Abu Saadeh, F, O'Toole S, Marchocki Z, Gleeson N, Norris LA, Optimisation of Thrombin Generation as a Predictive Biomarker for Venous Thromboembolism in Gynaecological Malignancies, Research Practice in Thrombosis and Haemostasis, International Society for Thrombosis and Haemostasis, Dublin, July 2018, 2, (Supplement 1), Wiley, 2018, ppPB518 - PB518 Published Abstract, 2018 DOI

Z. Marchocki, N. Gleeson, F. Abu Saadeh, M.P. Ward, S.A. O'Toole, L.A. Norris, Fibrinogen, D-Dimers and thrombin generation assays as predictors of the risk of recurrent VTE in patients with gynaecological malignancies, Thrombosis Research, International Congress on Thrombosis and Haemostasis Issues in Cancer, Bergamo, April 2018, 164, (Supplement 1), 2018, pp200 - 200 Published Abstract, 2018 DOI

Saadeh Feras Abu, Riain Ciaran O, Mc Cormack Ciara, Gleeson Noreen, Lung metastases from benign uterine leiomyoma: does 18-FDG-PET/CT have a role to play? , Irish Journal of Medical Science , 2018 Journal Article, 2018 DOI

M.P. Ward1, F.A. Saadeh2, J.J. O'Leary3, N. Gleeson1,4, S.A. O'Toole1,3, L.A. Norris1, The Effect of Neoadjuvant Chemotherapy on the Activated Protein C (aPC) Pathway in High Grade Serous Ovarian Cancer Patients, ISTH , Berlin, 2017, 2017 Published Abstract, 2017 URL

C. Spourquet1, M.P. Ward1, F.A. Saadeh2, J.J. O'Leary3, N. Gleeson1,2, S.A. O'Toole1,3, L.A. Norris1, Expression of Coagulation Proteases from the Activated Protein C Pathway in Ovarian Tumours, ISTH, Berlin, 2017 Published Abstract, 2017 URL

Thompson C, Abu Saadeh F, AN ALTERNATIVE ROLE FOR A BREAST IMPLANT FOLLOWING TOTAL PELVIC EXENTERATION , 19th International Meeting of the European Society of Gynaecological Oncology, Vienna, Austria , 2017, 27 , LIPPINCOTT WILLIAMS & WILKINS TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA â€" , 2017, pp1387 - 1387 Published Abstract, 2017

Marchocki Z, Abu Saadeh F, MESONEPHRIC LIKE ENDOMETRIOID UTERINE CARCINOMA-A CASE REPORT. , 19th International Meeting of the European Society of Gynaecological Oncology, Vienna, Austria , 2017, 27 , LIPPINCOTT WILLIAMS & WILKINS TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA â€" , 2017, pp1151 - 1151 Published Abstract, 2017

Dr. Sarah Petch, Dr. Aleksandra Sobota, Dr. Claire Thompson, Dr. Ciaran O'riain, Dr. Dr Feras Abu Saadah, Sister Mary Joseph Nodule- An Unusual Site For Endometrioid Cancer Metastasis. A Case Report., Fourth Irish Congress of Obstetrics, Gynaecology & Perinatal Medicine, Ireland, 2017 Poster, 2017 URL

Marchocki Z, McDonnell S, Thompson C, Kamran W, Abu Saadeh F, SQUAMOUS CELL CARCINOMA ARISING IN A MATURE CYSTIC TERATOMA-TWO CASE REPORTS , 19th International Meeting of the European Society of Gynaecological Oncology, Nov 2017, Vienna, Austria , 2017, 27 , LIPPINCOTT WILLIAMS & WILKINS TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA â€" , 2017, pp1588 - 1588 Published Abstract, 2017

Katie Field, Lucy Norris, Feras Abu Saadeh, Mark Ward,Hugh O'Connor & Noreen Gleeson, miRNA, a possible solution to the search in Biomarkers for Endometriosis?, 13th World congress on Endometriosis , Vancouver, 2017 Conference Paper, 2017

Katie Field, Lucy Norris, Feras Abu Saadeh, Mark Ward,Hugh O'Connor & Noreen Gleeson, The role of IL-6, MMP-2 and MMP-9 as Biomarkers for Endometriosis, 13th World congress on Endometriosis , Vancouver, 2017, 2017 Conference Paper, 2017

Thompson C, O'Riain C, Abu Saadeh F, A CASE OF MALIGNANT STRUMA OVARII CONFINED TO THE OVARY WITH SYNCHRONOUS PAPILLARY THYROID CARCINOMA DETECTED FOLLOWING THYROIDECTOMY , 19th International Meeting of the European Society of Gynaecological Oncology, Vienna, Austria , 2017, 27 , LIPPINCOTT WILLIAMS & WILKINS TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA â€" , 2017, pp1691 - 1691 Published Abstract, 2017

Cathy Spillane, Brendan Ffrench, Anthony Cooney, Carmel Ruttle, Anna Bogdanska, Noreen Gleeson, Feras Abu Saadeh, Waseem Kamran, Ciaran O'Riain, Ricahrd Flavin, Michael Gallagher, Cara M Martin, Orla Sheils, Sharon O'Toole, John J O'Leary, A Digital Pathology Method to Identify All Forms of CTC, LABORATORY INVESTIGATION, USCAP, 97, Nature Publishing Group, 2017, pp463 - 463 Published Abstract, 2017

Marchocki Z, Abu Saadeh F, Gleeson N, Norris L, Risk of recurrence of venous thromboembolism in patients with gynaecological cancer, Thrombosis Research, Womens Issues in Thrombosis and Haemostasis, Barcelona, March 2017, 151, (Supplement 1), 2017, ppS133 - S133 Published Abstract, 2017 DOI

Marchocki Z, Riain CO', Thompson C, Abu Saadeh F, CANCER-RELATED SEVERE HYPERCALCEMIA IN OVARIAN ADENOSARCOMA-A CASE REPORT , 19th International Meeting of the European Society of Gynaecological Oncology, Vienna, Austria , 2017, 27 , LIPPINCOTT WILLIAMS & WILKINS TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA â€" , 2017, pp1589 - 1589 Published Abstract, 2017

Marchocki Z, Saadeh F Abu, Gleeson N, Norris L, P-077: Risk of recurrence of venous thromboembolism in patients with gynaecological cancer , The 6th International Symposium on Women's Health Issues in Thrombosis and Haemostasis (WITH), Spain , 151 , 2017, ppS133 - Published Abstract, 2017

Marchocki Z, O'Riain C, Kamran W, Abu Saadeh F, HIGH GRADE ENDOMETRIAL STROMAL SARCOMA ASSOCIATED WITH YWHAE-FAM22 REARRANGEMENT-TWO CASE REPORTS. , 19th International Meeting of the European Society of Gynaecological Oncology, Vienna, Austria , 2017, 27 , LIPPINCOTT WILLIAMS & WILKINS TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA â€" , 2017, pp1150 - 1150 Published Abstract, 2017

Spillane C, Ffrench B, Cooney A, Ruttle C, Bogdanska A, Gleeson N, Abu Saadeh F, Waseem K, O'Riain C, Flavin R, A NOVEL DIGITIAL PATHOLOGY APPROACH TO DEFINITIVELY IDENTIFY OVARIAN CANCER CTCS , 2016, 26 , LIPPINCOTT WILLIAMS & WILKINS TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA â€" , 2016, pp796 - 796 Published Abstract, 2016 URL

Field K, Ryan MJ, Saadeh FA, Kamran W, Brennan V, Gillham C, Gleeson N, Selective arterial embolisation for intractable vaginal haemorrhage in genital tract malignancies , Eur J Gynaecol Oncol , 37 , (03 ), 2016, p736 - 740 Journal Article, 2016 DOI

Abu Saadeh, F, Langhe R, Galvin DM, O Toole SA, O'Donnell DM, Gleeson N, Norris LA, Procoagulant activity in gynaecological cancer patients; the effect of surgery and chemotherapy. , Thrombosis Research, 139, 2016, p135 - 141 Journal Article, 2016 DOI

Petch S, Norris L, O'Toole S, Gleeson N, Abu Saadeh F. , Peri operative venous thromboembolism prophylaxis in gynaecological cancer patients. A survey of current practice., Thrombosis Research, 145, 2016, p126 - 128 Journal Article, 2016 DOI

Martin F, Long JC, O'Toole SA, O'Leary JJ, Abu Saadeh F, Gleeson N, Norris LA, Tumour expression of coagulation proteases of the aPC pathway - a role in the pathogenesis of gynaecological cancers?, Thrombosis Research, International Congress on Thrombosis and Haemostasis Issues in Cancer, Bergamo, April 2016, 140, (Supplement 1), 2016, ppS181 - S181 Published Abstract, 2016 DOI

Norris LA, Martin FA, O'Toole SA, Saadeh FA, Gleeson N, PO-24 - Determinants of thrombin generation in gynaecological malignancies., 2016 Published Abstract, 2016 DOI

Wahab NAA, Saadeh FA, Wong A, Gleeson N, Negative pressure wound treatment (NPWT) in vulva and groin wounds in gynaecologic oncology. , European journal of gynaecological oncology , 37 , (5 ), 2016, p632 - 637 Journal Article, 2016 URL

Martin F, O'toole SA, Long JC, O'leary JJ, Gleeson N, Saadeh FA, Norris LA, expression of coagulation proteases from the Apc pathway in tumours from gynaecological cancer patients with and without venous thrombosis: Or360 , 13 , 2015, pp233 - 234 Published Abstract, 2015 URL

Saadeh Feras Abu, Galvin Daniel, Alsharbaty Mohammed J, Gleeson Noreen, Case Report: Paravaginal aggressive angiomyxoma , BMJ case reports , 2015 , 2015 Journal Article, 2015 URL

O'Gorman C, Burke N, Norris L, Gleeson N, Abu Saadeh F, Reducing venous thromboembolic events associated with ovarian cancer: are we winning the battle? , THROMBOSIS RESEARCH, 2015, 135 , PERGAMON-ELSEVIER SCIENCE LTD THE BOULEVARD, LANGFORD LANE, KIDLINGTON â€" , 2015, ppS66 - S66 Published Abstract, 2015

Saadeh FA, Cheema I, McCormick P, Gleeson N, Co-Operative Radical Pelvic Surgery: A Role for the Gynecologist in Vaginal Reconstruction Using a Uterine Myoserosal Flap in Urological and Anorectal Cancer Surgery., International Journal of Gynecological Cancer, 25, (5), 2015, p931 - 936 Journal Article, 2015 URL

Horan M, Demaio A, Abu Saadeh F, O'Riain C, Gleeson N, GLASSY CELL CARCINOMA OF THE CERVIX: A CASE SERIES , 2015, 25 , (9 ), LIPPINCOTT WILLIAMS & WILKINS TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA â€" , 2015, pp820 - 820 Published Abstract, 2015

Shireen R, Norris L, Cullen M, Zainulabdin A, Long JC, McKendry K, Martin F, Cooney A, Ripollone S, Ibrahim N, CAN HUMAN EPIDIDYMIS PROTEIN 4 (HE4) IDENTIFY OCCULT ENDOMETRIAL CARCINOMA IN WOMEN WITH ATYPICAL HYPERPLASIA? , 2015, 25 , (9 ), LIPPINCOTT WILLIAMS & WILKINS TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA â€" , 2015, pp1143 - 1143 Published Abstract, 2015

Saadeh Feras Abu, Collins Vicki, Al-Saadi Maimuna, Gleeson Noreen, Case Report: An unusual relapse in acute myeloid leukaemia , BMJ CASE REPORTS , 2015 , 2015 Journal Article, 2015

Wahab Nor Azlia Abdul, Saadeh Feras Abu, Lavelle Mairr, Gleeson Noreen, Could sentinel node mapping of the groin cause extranodal metastasis in vulva cancer? , Gynecologic and obstetric investigation , 79 , (4 ), 2015, p280 - 284 Journal Article, 2015 URL

O'toole P Sa, Rizmee S, Norris L, Cullen M, Zainulabdin A, Long JC, Martin F, Cooney A, Ripollone S, Ibrahim N, utility of Serum He4 in Diagnosis and Prognosis of Endometrial Cancer , 237 , 2015, ppS15 - Published Abstract, 2015 URL

Obeidi Nedaa, Tchrakian Nairi, Saadeh Feras Abu, Mocanu Edgar, Case Report: Suspected ovarian molar pregnancy after assisted reproductive technology conception: a diagnostic challenge , BMJ case reports , 2015 , 2015 Journal Article, 2015 URL

Langhe R, Norris L, Saadeh FA, Blackshields G, Varley R, Harrison A, Gleeson N, Spillane C, Martin C, O'Donnell DM, D'Arcy T, O'Leary J, O'Toole S, A novel serum microRNA panel to discriminate benign from malignant ovarian disease., Cancer letters, 356, (2 Pt B), 2015, p628-36 Journal Article, 2015 DOI

Kamran MW, O'Toole F, Meghen K, Wahab AN , Abu Saadeh F, Gleeson N, Whole-body [18F]fluoro-2-deoxyglucose positron emission tomography scan as combined PET-CT staging prior to planned radical vulvectomy and inguinofemoral lymphadenectomy for squamous vulval cancer: A correlation with groin node metastasis , European Journal of Gynaecological Oncology, 35, (3), 2014, p230 - 235 Journal Article, 2014

Ibrahim. N, Norris. L, O'Toole. S, McHugh, T. Abu Saadeh. F, Gleeson. N. , Does the extended thromboprophylaxix help to reduce the incidence of venous thromboembolism in gynaecological cancer patients ?, THROMBOSIS RESEARCH, THROMBOSIS RESEARCH, 133, (S244), 2014 Published Abstract, 2014

Abu Saadeh Feras, Wahab Nor, Gleeson N, An unusual presentation of endometriosis, British Medical Journal Case Reports , doi:10.11/bcr-2014-2, 2014 Journal Article, 2014 URL

Abu Saadeh F, O'Toole S, Gleeson N, Norris L, Peak ant-Xa levels following LMWH (tinzaparin) prophylaxis in gynaecological cancer patients post surgery, Thrombosis Research, 7th Internation Conference on Thrombosis & Hemostatis Issues in Cancer, , Bergamot Italy, May 2014, edited by A Falanga, B. Brenner, F, Rickles , 133, (Suppl 2), Elsevier, 2014 Published Abstract, 2014

Laios A, Mohamed BM, Kelly L, Flavin R, Finn S, McEvoy L, Gallagher M, Martin C, Sheils O, Ring M, Davies A, Lawson M, Gleeson N, D'Arcy T, d'Adhemar C, Norris L, Langhe R, Saadeh FA, O'Leary JJ, O'Toole SA, Pre-Treatment of Platinum Resistant Ovarian Cancer Cells with an MMP-9/MMP-2 Inhibitor Prior to Cisplatin Enhances Cytotoxicity as Determined by High Content Screening., International journal of molecular sciences, 14, (1), 2013, p2085-103 Journal Article, 2013 TARA - Full Text DOI

Abu Saadeh F, Norris L, O'Toole S, Gleeson N, Venous thromboembolism in ovarian cancer: Incidence, risk factors and impact on survival., European Journal of Obstetrics & Gynecology and Reproductive Biology , 170, (1), 2013, p214 - 218 Journal Article, 2013 Other

Meghan K, O'Toole F, Wahab A, Kamran W, Gleeson N, Abu Saadeh F, NEGATIVE PREDICTIVE VALUE OF PET-CT NODAL STATUS IN WOMEN WITH OPERABLE CERVIX CANCER , 2013, 23 , (8 ), LIPPINCOTT WILLIAMS & WILKINS 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA , 2013 Conference Paper, 2013

Kamran MW, Vaughan D, Crosby D, Wahab NA, Saadeh FA, Gleeson N, Opportunistic and interventional salpingectomy in women at risk: a strategy for preventing pelvic serous cancer (PSC)., European journal of obstetrics, gynecology, and reproductive biology, 170, (1), 2013, p251-4 Journal Article, 2013 URL

Feras Abu Saadeh, Hypercoagulability in Ovarian Cancer, TCD, 2013 Thesis, 2013 URL

O'Toole F, Meghan K, Wahab A, Abu Saadeh F, Gleeson N, FDG PET-CT IN PRE-OPERATIVE ASSESSMENT OF VULVAL CARCINOMA. A SINGLE INSTITUTION'S EXPERIENCE OVER FOUR YEARS , 2013, 23 , (8 ), LIPPINCOTT WILLIAMS & WILKINS 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA , 2013 Conference Paper, 2013

Abu Saadeh F, Cheema I, Gleeson N, VAGINAL AND VESTIBULAR RECONSTRUCTION FOLLOWING RADICAL CYSTECTOMY AND URETHRECTOMY: A NEW TECHNIQUE , 2013, 23 , (8 ), LIPPINCOTT WILLIAMS & WILKINS 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA , 2013 Conference Paper, 2013

Langhe R, Norris L, Petzold M, Abu Saadeh F, Kamran W, Ibrahim N, Nassan M, Gleeson N, O'Leary JJ, O'Toole S, ROMA INDEX IMPROVES SPECIFICITY OF OVARIAN CANCER DIAGNOSIS COMPARED TO CA125 ALONE , 2013, 23 , (8 ), LIPPINCOTT WILLIAMS & WILKINS 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA , 2013 Conference Paper, 2013

O'Malley Eimer, Saadeh Feras Abu, Nor Azlia, DIVERSE PRESENTATIONS OF TUBERCULOSIS IN OBSTETRICS AND GYNAECOLOGY , 2013, 2013, pp68 - Conference Paper, 2013

Wahab N Abdul, Abu Saadeh F, Lavelle M, Gleeson N, COULD SENTINEL NODE MAPPING OF GROIN LYMPH NODES CAUSE EXTRANODAL METASTASES IN VULVA CANCER? , 2013, 23 , (8 ), LIPPINCOTT WILLIAMS & WILKINS 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA , 2013 Conference Paper, 2013

Abu Saadeh, Norris L, O'Toole S, Mohamed BM, Langhe R, O'Leary J, Gleeson N, Tumour expresion of tissue factor and tissue factor pathway inhibitor in ovarian cancer- relationship with venous thrombosis risk., Thrombosis Research, 132, 2013, p627 - 634 Journal Article, 2013 DOI

Abu Saadeh F, Norris L, O'Toole S, Langhe R, O'Leary JJ, Gleeson N., Does tissue factor and tissue factor pathway inhibitor over-expression play a role in the development of venous thromboembolism in ovarian cancer patients?, Thrombosis Research, 6th International Conference on Thrombosis & Hemostasis Issues in Cancer, Bergamo Italy, April 2012, edited by A Falanga, B. Brenner, F, Rickles , 129, ((Suppl 1)), Elsevier, 2012, pp170- Published Abstract, 2012 URL

Abu Saadeh F, Norris L, O'Toole S, Langhe R, Gleeson N., Procoagulant activity in patients with gynecological malignancies and the effect of neoadjuvant chemotherapy , Thrombosis Research, 6th International Conference on Thrombosis & Hemostasis Issues in Cancer, Bergamo Italy, April 2012, edited by A Falanga, B. Brenner, F, Rickles , 129, (Suppl 1), Elsevier, 2012 Published Abstract, 2012 URL

O'Brien Y, Abu Saadeh F, O'Donnell D, Gleeson N, PARANEOPLASTIC SENSORY NEUROPATHY IN OVARIAN CANCER , 2011, 180 , SPRINGER LONDON LTD 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND , 2011, pp133 - 133 Conference Paper, 2011

Abu Saadeh F, Norris L, OToole S, Gleeson N, P. 86 The role of tissue factor and tissue factor pathway inhibitor in ovarian cancer , 127 , (3 ), 2011, pp1 - Published Abstract, 2011

O'Brien Y, O'Neill A, Abu Saadeh F, Gleeson N, PERIPARTUM CARDIOMYOPATHY , 2011, 180 , SPRINGER LONDON LTD 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND , 2011, pp132 - 132 Conference Paper, 2011

Field K, Saadeh F, Hewitt M, O'Reilly B, Keogh J, Improving the maternal experience: watching your baby being delivered during caesarean section , 95 , (Suppl 1 ), 2010, ppFa66 - Fa66 Published Abstract, 2010

Nikhil Purandare, Irfan Ahmed, Seiglinde Muller, Firas Saadeh, Mother to Child Transmission of HIV; Are We Doing Enough? , Journal of South Asian Federation of Obstetrics and Gynecology , 1 , (3 ), 2009, p29 - 32 Journal Article, 2009

Saadeh F Abu, Hickey Mr, Should cold coagulation be the new gold standard treatment for treating Cin in young women: Fc2. 07 , 115 , 2008, pp39 - Published Abstract, 2008

Non-Peer-Reviewed Publications

Feras Abu Saadeh, PALB2, ATM and Ovarian Cancer, Review of PALB2, ATM and Ovarian Cancer, by arbajal Mamani, Semiramis; Markham, Merry; Castagno, Jacqueline; Cardenas Goicoechea, Joel , BMJ CASE REPORTS , 2019 Review, 2019

Feras Abu Saadeh, HPV-NEGATIVE VULVAR SQUAMOUS CELL CARCINOMA IN A 21-YEAR-OLD PATIENT, by Ferreira, Dânia; Almeida, Amélia; Patrício, Vanda; Petiz, Almerinda , BMJ Case Reports, 2019 Review, 2019

Feras Abu Saadeh, The bidirectional association among female hormone-related cancers: breast, ovary, and uterine corpus" for Cancer Medicine., Review of The bidirectional association among female hormone-related cancers: breast, ovary, and uterine corpus" for Cancer Medicine., by Min‐Chi Chen Kuan‐Der Lee Chang‐Hsien Lu Ting‐Yao Wang Shih‐Hao Huang Chao‐Yu Chen , cancer Medicine, 2018 Review, 2018

Feras Abu Saadeh, Cancer and thrombosis, Real life experience, Joint National Haematology /Obstetrics Study day, Cork, 2018 Invited Talk, 2018

Feras Abu Saadeh, Intravenous leiomyomatosis with skip metastasis, Review of Intravenous leiomyomatosis with skip metastasis, by Yunzhu Li; Qi Miao; Ninghai Cheng; Guotao Ma , World Journal of Surgical Oncology, 2018 Review, 2018

Feras Abu Saadeh, Benign Metastasizing Leiomyoma to the lungs: a rare cause of pulmonary nodules, Review of Benign Metastasizing Leiomyoma to the lungs: a rare cause of pulmonary nodules, by Campanha, Rafaela; Malheiro, Mariana; Rosa, Rita; Barata, Catarina , BMJ CASE REPORTS , 2018 Review, 2018

Feras Abu Saadeh, Bowel Injury in Laparoscopic Gynaecology Cancer, GLOS course, Dublin, 2017, RCSI Invited Talk, 2017

Feras Abu Saadeh, A complete hydatidiform mole in a perimenopausal woman, Review of A complete hydatidiform mole in a perimenopausal woman, by Dockx, Sofie; Peeters, Frederik; Buytaert, Guy; Jacquemyn, Yves , BMJ CASE REPORTS , 2017 Review, 2017

Feras Abu Saadeh, LMWH for women with cancer and VTE, how long and what dose, Expert meeting, Thrombosis in women and cancer , Spain , 2017 Invited Talk, 2017

Feras Abu Saadeh, Specificity and predictive value of biomarkers for the risk of thrombosis in pancreatic adenocarcinoma, Review of Specificity and predictive value of biomarkers for the risk of thrombosis in pancreatic adenocarcinoma, by Faille, Dorothée; Bourrienne, Marie-Charlotte; de RAUCOURT, Emmanuelle; De Chaisemartin, Luc; Granger, Vanessa; Lacroix, Romaric; Panicot-Dubois, Laurence; Hammel, Pascal; Lévy, Philippe; Ruszniewski, Philippe; Ajzenberg, Nadine; Rebours, Vinciane , Thrombosis and Haemostasis,, 2017 Review, 2017

Feras Abu Saadeh, An integrated approach for identifying genes associated with chemotherapy resistance in high-grade serous epithelial ovarian cancer, Review of An integrated approach for identifying genes associated with chemotherapy resistance in high-grade serous epithelial ovarian cancer, Ahmed Hossain, Gias Uddin Ahsan, Hayatun Nabi , Advances in Modern Oncology Research, 2017 Review, 2017 URL

Feras Abu Saadeh, Institute Spring Meeting, Joint meeting of IOG and the Irish Society of Interventional Radiology, 2017 Meetings /Conferences Organised, 2017

Feras Abu Saadeh, The 7th international Symposium on Women's Health Issues in Thrombosis and Haemostasis , 2017, Spain Meetings /Conferences Organised, 2017

Feras Abu Saadeh, Creation of risk index for premalignant changes of portio vaginalis uteri, Review of Creation of risk index for premalignant changes of portio vaginalis uteri, by LIDIJA DRAGOLJUB TASIC, PROF; LJILJANA GOJKO ANTIC, DR; ALEKSANDAR ILIJA JURISIC, ASS PROF; SVETLANA DIMITRIJE JANKOVIC, ASS PROF; DRAGAN ZIVORAD ANTIC, DR; AMIRA SAHIB EGIC, PROF; NATASA TRIFUN KARADZOV, ASS; NEBOJSA BORIVOJE ZECEVIC, ASS; SLADJANA JOVICA MIHAJLOVIC, DR , BMC Women's Health, 2017 Review, 2017

Feras Abu Saadeh, Interactive session on cancer and thrombosis, Junior Obstetrics and Gynaecology Society Meeting , Ireland, 2016 Invited Talk, 2016

Feras Abu Saadeh, Comparisons of the survival time of patients with ovarian cancer adopting post-operative chemotherapy by use of paclitaxel combined with carboplatin or nedaplatin, Review of Comparisons of the survival time of patients with ovarian cancer adopting post-operative chemotherapy by use of paclitaxel combined with carboplatin or nedaplatin, by Yimin Han; Hongfei Gao; Lijun Yuan , World Journal of Surgical Oncology, 2016 Review, 2016

Feras Abu Saadeh, Hyperthermic Intraoperative Intraperitoneal Chemotherapy (HIPEC): its place in gynaecological oncology, Review of Hyperthermic Intraoperative Intraperitoneal Chemotherapy (HIPEC): its place in gynaecological oncology, o Journal of Cancer Biology & Research, 2016 Review, 2016

Feras Abu Saadeh, VTE in gynaecological cancer - who is at risk and when?, The Irish Society of Gynaecological Oncology (ISGO) Annual Scientific Meeting Dublin, Ireland. December 2016, Ireland, 2016, 2016 Invited Talk, 2016

Feras Abu Saadeh, Preoperative Differentiation between Malignant and Benign Ovarian Masses in Patients with Normal CA-125 Levels, Review of Preoperative Differentiation between Malignant and Benign Ovarian Masses in Patients with Normal CA-125 Levels, International Journal of Cancer and Clinical Research, 2016 Review, 2016

Feras Abu Saadeh, Risk Factors for Venous Thromboembolism (VTE) in Cancer Patients Receiving Chemotherapy, Review of Risk Factors for Venous Thromboembolism (VTE) in Cancer Patients Receiving Chemotherapy, Journal of Community and Supportive Oncology, 2016 Review, 2016

Feras Abu Saadeh, Cancer, Women & Thrombosis. The Unanswered Questions, World thrombosis day, Ireland, 2016 Invited Talk, 2016

Feras Abu Saadeh, Role of surgery in ovarian cancer, Ovarian Cancer Patient Day, Ireland, 2015 Invited Talk, 2015

Feras Abu Saadeh, Make ureter your friend, 3rd Irish Congress of Obstetrics Gynaecology and perinatal medicine, Ireland, 2015 Invited Talk, 2015

Feras Abu Saadeh, Aggressive angiomyxoma of the pelvis: dramatic response to chemical ablation therapy, Review of Aggressive angiomyxoma of the pelvis: dramatic response to chemical ablation therapy, by Chuang He; Yang Li; Yun Liu; Li Yang; De-yu Guo; xuequan huang , BMC Women's Health, 2015 Review, 2015

Feras Abu Saadeh, Elevated preoperative plasma D‑dimer levels show correlation with poor prognosis in serous ovarian cancer patients with absence of venous thromboembolism (VTE), Review of Elevated preoperative plasma D‑dimer levels show correlation with poor prognosis in serous ovarian cancer patients with absence of venous thromboembolism (VTE), Biomarkers, 2015 Review, 2015

Feras Abu Saadeh, Cancer and thrombosis, Gynaecological Traveller, Ireland, 2014 Invited Talk, 2014

Feras Abu Saadeh, Venous thromboembolism Gynaecological Cancer - Risk, Pathogenesis and Clinical Significance" , Master class on thrombosis and cancer/ Trinity College Dublin , Ireland, 2013 Invited Talk, 2013

Edward Barrett and Marie Redmond, Contextual Media, USA, MIT Press, 1997 Book, 1997

Research Expertise

Projects

  • Title
    • A risk model for prediction of venous thromboembolism in gynaecological cancer patients post surgery
  • Summary
    • Venous thromboembolism (VTE) is a common cause of death in patients with solid tumours. Cancer itself causes a hypercoagulable state, in addition chemotherapy and surgery enhance the risk. Gynaecological cancers have been associated with high rates of VTE which is excacerbated by pelvic surgery and chemotherapy. A recent study in our centre showed that one third of VTE in ovarian cancer patients occurs within 5 days of surgery despite heparin prophylaxis. Recently, clinical risk models have been developed to predict VTE in patients undergoing chemotherapy, these models have been shown to be more powerful when combined with haemostatic biomarkers. Thrombus formation is complex in cancer and is thought to result from a release of procoagulant material from the tumour combined with damage to the endothelium as a result of chemotherapy and surgery. Global tests of hypercoagulability which capture these effects are therefore attractive as determinants of thrombotic risk. Calibrated automated thrombograpy (CAT) is a recently developed global test which measures thrombin generation in plasma. Increased thrombin generation is predictive of VTE in a variety of clinical settings. The overarching aim of this project is to develop and validate a specific risk scoring model for VTE risk in gynaecological cancer patients using a combination of easily available clinical and laboratory parameters and haemostatic biomarkers. In a large population of gynaecological cancer patients, we will identify the key risk factors for VTE and use them to derive a risk score model. Based on our pilot data, we believe that a thrombin generation test may be a useful biomarker for VTE in gynaecological cancer. By understanding the mechanisms by which gynaecological cancer increases procoagulant activity, we will optimise a specific thrombin generation assay which when combined with the derived risk score model will accurately identify gynaecological cancer patients at high risk of VTE.
  • Funding Agency
    • HRB
  • Date From
    • 2013
  • Date To
    • 2017
  • Title
    • Towards increased awareness and understanding of the risk of thrombosis in gynaecological cancers
  • Summary
    • A recent survey of patients who suffered a thrombosis during their cancer journey showed that, generally, patients are not warned about the risk of clots during cancer and are not told what to look out for. In addition research by our group has shown that only 45% of gynaecologists in Europe are using the correct guidelines for thrombosis prevention. The aim of this project is to increase awareness among patients regarding thrombosis and to provide an opportunity for knowledge exchange between gynaecologist and scientists working in the area
  • Funding Agency
    • HRB
  • Date From
    • 2015
  • Date To
    • 2017
  • Title
    • Gynaecological cancer patients experience of extended LMWH prophylaxis post surgery.
  • Summary
    • Venous thromboembolism (VTE) is a common post-operative complication in cancer patients associated with high mortality rates. The presence of a gynaecological malignancy increases the rate of post operative VTE fourfold compared with patients with benign disease. Among cancer patients who develop a venous thromboembolism postoperatively, 40% will do so 21 days after surgery(1). Among endometrial cancer patients diagnosed with venous thromboembolism, a recent study of a large national quality database found that 73% of minimally invasive surgery and 43% of open surgery patients are diagnosed with a venous thromboembolism after hospital discharge (2). In line with these findings, the American College of Chest Physicians recommends the use of extended duration prophylaxis for patients with cancer undergoing abdomino-pelvic surgery (3). From May 2012, all patients undergoing surgery for a gynaecological malignancy in our centre receive 28 days extended LMWH prophylaxis post surgery. Studies in other centres have reported that translation of the guidelines for prophylaxis into clinical practice has been problematic (4). Introduction of extended prophylaxis is an additional burden on the cancer patient as they are responsible for purchasing, and in many cases, self-injecting the medication. Additional educational and support services are also required in the community for these patients. In other patient groups, lack of education and a negative opinion toward injection has affected compliance (5). The cancer patient may have additional difficulty as they are managing multiple symptoms and treatments. Among gynaecological cancer patients, the patient experience of extended prophylaxis has not been documented and compliance is largely unknown.
  • Funding Agency
    • LeoPharma
  • Date From
    • 2018
  • Date To
    • 2019
  • Title
    • A study to determine the effects of extended (28 days) LMWH prophylaxis on the incidence of venous thromboembolism in gynaecological cancer patients post surgery- 5 year review.
  • Summary
    • Gynaecological cancers, and in particular adenocarcinomas are associated with a very high risk of venous thromboembolism (VTE) with rates as high as 42% reported for clear cell cancer of the ovary . Patients are particularly at risk during the postoperative period where VTE occurs in 6-7% of patients despite LMWH prophylaxis. In addition, recent evidence has suggested that a substantial proportion of VTE occurs beyond hospital stay. Among gynaecological cancer patients who develop VTE, 40% occur > 21 days post surgery . Minimally invasive surgery is increasingly used for gynaecological cancer surgery, although this has significantly reduced the incidence of VTE, it has not eliminated this risk post surgery [4. Among patients who suffer a VTE following minimally invasive surgery for endometrial cancer, 73% were diagnosed with a VTE after discharge compared with 43% for open surgery patients. The mean time to VTE was 10 days for minimally invasive surgery and 14 days for open surgery patients. A randomised trial comparing 28 days prophylaxis with LMWH following major abdominal surgery for cancer with 7 days prophylaxis showed a 60% reduction in VTE in the extended prophylaxis group without any substantial risk of bleeding.
  • Funding Agency
    • LeoPharma
  • Date From
    • 2018
  • Date To
    • 2020
  • Title
    • Lymph node metastasis and thrombosis risk in Gynaecological cancer patients post surgery
  • Summary
    • Gynaecological cancer is associated with an increased incidence of venous thromboembolism (VTE) even with appropriate thromboprophylaxis. The risk is greatest following surgery and can persist for up to 6-12 months post surgery. The focus of our research group is to determine clinical and haemostatic biomarkers for VTE post surgery in order to identify high risk gynaecological cancer patients who may benefit from more tailored LMWH prophylaxis Lymph node dissection (LND) is a common procedure in gynaecological cancer surgery and increases the complications and complexity of the surgery. Reports in other cancers suggest an association between lymph node metastasis and post operative thrombo embolic complications. However there is very little data on gynaecological cancers. In addition, none of the current risk scores for thrombosis account for LND, The aim of our study is to investigate the role of lymph node metastasis in VTE following both open and laparoscopic surgery for gynaecological cancer.
  • Funding Agency
    • LeoPharma
  • Date From
    • 2019
  • Date To
    • 2021

Keywords

DEEP VENOUS THROMBOSIS; Gynaecology oncology; OVARIAN-CANCER; Thrombosis; VENOUS THROMBOSIS

Recognition

Representations

Editorial Board of Advances in Modern Oncology Research 2015

Medical Advisory Board of OvaCare 2012

Editorial Board of International Journal of Gynecology & Clinical Practice 2015

National representative at ENYGO 2013

Chair the session on women cancer and thrombosis of The 7th International Symposium on Women's Health Issues in Thrombosis and Haemostasis (WITH)

forum/dicussion group Expert meeting, Thrombosis in women with cancer

Member of the National Cancer Control Programme guideline group

Awards and Honours

1st Class honours, Medicine, Surgery, Paediatrics, Obstetrics and Gynaecology 1999

Best oral presentation, ICOGPM 1/12/2012

Best oral presentation, JOGS 24/11/2014

Memberships

Member of Royal College of Obstetrician & Gynaecologist 2006 – Date

National representative at ENYGO 2011 – 2013

Member of Royal College of Physicians of Ireland 2006 – Date

Member of Irish Medical Council "Full Registration" 2005 – Date

Member of British Society of Colposcopy and Cervical Pathology 2009 – Date

Member of International Society of Ultrasound in Obsetrics & Gynaecology 2011 – Date

Member od ESGO 2011 – Date

Member of Jordan Medical Association "Full Registration" 1999 – Date

Member and Founder of Palestinian Society of Obstetrics & Gynaecology 2001 – Date