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Professor Roman Romero-Ortuno
Associate Professor Consultant, Medical Gerontology

Biography

Roman Romero-Ortuno is Associate Professor in Medical Gerontology at Trinity College Dublin and Consultant Physician in St. James's Hospital, Dublin.

In 2002, he graduated from University of Barcelona with a degree in Medicine, and in 2003 he completed an MSc in European Social Policy at the London School of Economics and Political Science. He has a music degree from the Conservatory of Barcelona. His basic postgraduate medical training took place in Manchester and London and his higher medical training in Geriatric and General (Internal) Medicine was completed in Dublin.

Between 2014 and 2018 he worked as a Consultant Geriatrician in Addenbrooke's Hospital (Cambridge University Hospitals NHS Foundation Trust) and during that time he held an Honorary Visiting Fellowship to the Clinical Gerontology Unit of the Department of Public Health and Primary Care, University of Cambridge.

Prof. Ortuno is Faculty member of the Global Brain Health Institute (GBHI) where he brings clinical and academic expertise in frailty, dementia, delirium and comprehensive geriatric assessment. He co-chairs the Frailty and Resilience working group of The Irish Longitudinal Study on Ageing (TILDA) and the Irish Frailty Network Interest Group (IFN-IG) of the Irish Gerontological Society.

In December 2020, Prof. Ortuno was appointed as Associate Director of Postgraduate Teaching and Learning (M.D. Studies) in Trinity's School of Medicine.

His research contributions in the area of frailty have been recognised with the 2015 British Geriatrics Society Rising Star Award, the 2017 Count of Cartagena Award from the Royal National Academy of Medicine of Spain and the 2018 President of Ireland Future Research Leaders Award.

Publications and Further Research Outputs

Peer-Reviewed Publications

Roman Romero-Ortuno, Andreas E. Stuck, Tahir Masud, The giants of education in geriatric medicine and gerontology, Age and Ageing, 2022 Journal Article, 2022

Peter Hartley, Roman Romero-Ortuno, Christi Deaton, A mixed-methods feasibility study of a sit-to-stand based exercise programme to maintain knee-extension muscle strength for older patients during hospitalisation, Journal of Frailty, Sarcopenia and Falls, 2021 Journal Article, 2021 TARA - Full Text DOI

Lutz, Sebastian , Exploration of Deep Learning Techniques for Natural Image Matting, Trinity College Dublin.School of Computer Science & Statistics, 2021 E-Thesis, 2021 TARA - Full Text

Brendan Dee, Eilish Burke, Roman Romero-Ortuno, Philip McCallion, Mary McCarron, Factors associated with the progression of deficit accumulation frailty among adults with an intellectual disability: a systematic review revealing research gaps, HRB Open Research, 2021 Journal Article, 2021 DOI

Bailey L, Ward M, DiCosimo A, Baunta S, Cunningham C, Romero-Ortuno R, Kenny RA, Purcell R, Lannon R, McCarroll K, Nee R, Robinson D, Lavan A, Briggs R , Physical and Mental Health of Older People while Cocooning during the COVID-19 Pandemic, QJM, 2021 Journal Article, 2021 DOI TARA - Full Text

Duygu Sezgin, Mark O'Donovan, Jean Woo, Karen Bandeen-Roche, Giuseppe Liotta, Nicola Fairhall, Angel Rodríguez-Laso8, João Apóstolo, Roger Clarnette, Carol Holland, Regina Roller-Wirnsberger, Maddalena Illario, Leocadio Rodríguez Mañas, Miriam Vollenbroek-Hutten, Burcu Balam Yavuz, Cafer Balci, Francisco Orfila Pernas, Constança Paul, Emer Ahern, Roman Romero-Ortuno, William Molloy, Maria Therese Cooney, Diarmuid O'Shea, John Cooke, Deirdre Lang, Anne Hendry, Siobhán Kennelly, Kenneth Rockwood, Andrew Clegg, Aaron Liew, Rónán O'Caoimh, Early Identification of Frailty: Developing an International Delphi Consensus on Pre-frailty, Archives of Gerontology and Geriatrics, 2021 Journal Article, 2021 DOI

Frailty in, editor(s)Simon Conroy, Chris Carpenter, Jay Banerjee , Silver Book II: Quality care for older people with urgent care needs, London, British Geriatrics Society, 2021, [Andrew Clegg, Kenneth Rockwood, Roman Romero-Ortuno, Conal Cunningham] Book Chapter, 2021 DOI

Roman Romero-Ortuno, Peter Hartley, Rose Anne Kenny, Aisling O'Halloran, Frail by Different Measures: A Comparison of 8-year Mortality in The Irish Longitudinal Study on Ageing (TILDA), European Geriatric Medicine, 2021 Journal Article, 2021 TARA - Full Text DOI

Sebastian Moguilner, Silvin P. Knight, James R.C. Davis, Aisling M. O'Halloran, Rose Anne Kenny, Roman Romero-Ortuno, The importance of Age in the prediction of Mortality by a Frailty Index: A Machine Learning approach in The Irish Longitudinal Study on Ageing, Geriatrics, 2021 Journal Article, 2021 DOI

David Moloney, Rose Anne Kenny, Roman Romero-Ortuno, Longitudinal trajectories of pulse wave velocity and cognition in the Irish longitudinal study of ageing (TILDA), Journal of Human Hypertension, 2021 Annual Scientific Meeting of the British and Irish Hypertension Society (BIHS), Hilton Brighton Metropole, Brighton, 13-15 September 2021, 35, 2021, pp1 - 19 Poster, 2021 DOI TARA - Full Text

John Travers, Roman Romero-Ortuno, Éidin Ní Shé, Marie-Therese Cooney, Involving older people in co-designing a primary-care intervention to reverse frailty and build resilience, Family Practice, 2021 Journal Article, 2021 DOI TARA - Full Text

A.Monaghan, G. Jennings, F. Xue, S. Knight, R. Rizzo, J.Davis, E.Duggan, R.A. Kenny, R. Romero-Ortuño, ACUTE-PHASE BED-REST DURATIONWAS ASSOCIATED WITH LOWER GRIP STRENGTH IN A POST-COVID-19 COHORT, Annual and Scientific Meeting Virtual Meeting of the Irish Gerontological Society 70 Years of Change 1951-2021 18th November 2021, Online, 2021 Poster, 2021 DOI TARA - Full Text

Patrick J O'Donoghue, Paul Claffey, Ciara Rice, Lisa Byrne, Conal Cunningham, Rose Anne Kenny, Roman Romero-Ortuno, Association between gait speed and the SHARE Frailty Instrument in a Falls and Syncope Clinic, European Geriatric Medicine , 2021 Journal Article, 2021 DOI

Kieron Connolly, Conal Cunningham, Niamh Murphy, Roman Romero-Ortuno, Frances Horgan, Using Accelerometers in the Assessment of Sarcopenia in Older Adults Attending a Day Hospital Service in Ireland, Journal of Frailty, Sarcopenia and Falls, 2021 Journal Article, 2021 DOI

Silvin P. Knight, Louise Newman, John D. O'Connor, James Davis, Rose Anne Kenny, Roman Romero-Ortuno , Associations between neurocardiovascular signal entropy and physical frailty, Entropy, 2021 Journal Article, 2021 TARA - Full Text DOI

Denys Gibbons, Jake McDonnell, Daniel Ahern, Gráinne Cunniffe, Rose Anne Kenny, Roman Romero-Ortuno, Joseph Butler, The Relationship between Radiological Paraspinal Lumbar Measures and Clinical Measures of Sarcopenia in Older Patients with Chronic Lower Back Pain, Journal of Frailty, Sarcopenia and Falls, 2021 Journal Article, 2021 TARA - Full Text URL

David Moloney, Silvin P. Knight, Louise Newman, Rose Anne Kenny, Roman Romero-Ortuno, Eight orthostatic haemodynamic patterns in The Irish Longitudinal Study on Ageing (TILDA): stability and clinical associations after 4 years, Geriatrics, 2021 Journal Article, 2021 TARA - Full Text DOI

Silvin P. Knight, Louise Newman, Siobhan Scarlett, John D. O'Connor, James Davis, Celine De Looze, Rose Anne Kenny, Roman Romero-Ortuno, Associations between Cardiovascular Signal Entropy and Cognitive Performance over Eight Years, Entropy, 2021 Journal Article, 2021 TARA - Full Text DOI URL

T. J. Oscanoa, E. C. Cieza, O. Grimaldo, Y. B. Andia, F. A. Lizaraso-Soto, M. L. Guevara, R. M. Fujita & R. Romero-Ortuno, Use of Angiotensin II Receptor Blockers, Angiotensin I-Converting Enzyme Polymorphism and Associations with Memory Performance in Older People, Advances in Gerontology, 2021 Journal Article, 2021 DOI

Romero-Ortuno R, Hartley P, Knight SP, Kenny RA and O'Halloran AM, Frailty index transitions over eight years were frequent in The Irish Longitudinal Study on Ageing, HRB Open Research, 2021 Journal Article, 2021 DOI

Teodoro J. Oscanoa, Xavier Vidal, Eamon Laird, Rawia A. Ghashut, Geert A. Martens, Roman Romero-Ortuno, Severity and Mortality of SARS-COV-2 infection and 25-hydroxyvitamin D concentration: a metanalysis, Advances in Respiratory Medicine, 2021 Journal Article, 2021 DOI TARA - Full Text

Louise Newman, John D. O'Connor, Roman Romero-Ortuno, Richard B. Reilly, Rose Anne Kenny, Supine hypertension is associated with an impaired cerebral oxygenation response to orthostasis: Findings from the Irish Longitudinal Study on Ageing (TILDA), HYPERTENSION, 2021 Journal Article, 2021 DOI

Owen Thorpe, Elva McCabe, Elena Marie Herrero, William Ormiston Doyle, Aoife D Dillon, Lucinda Edge, Sinéad Flynn, Anna Mullen, Aisling Davis, Aoife Molamphy, Anna Kirwan, Robert Briggs, Amanda H Lavan, Darragh Shields, Geraldine McMahon, Arthur Hennessy, Una Kennedy, Paul Staunton, Emer Kidney, Sarah-Jane Yeung, Deirdre Glynn, Frances Horgan, Conal Cunningham, Roman Romero-Ortuno, Scoring the Clinical Frailty Scale in the Emergency Department: The Home FIRsT Experience, Journal of Frailty, Sarcopenia and Falls, 2021 Journal Article, 2021

J. Davis, S.P. Knight, R. Rizzo, O.A.Donoghue, R.A. Kenny, R. Romero-Ortuno, ASSOCIATIONS OF FRAILTY WITH CONSECUTIVE GAIT SPEED TRAILS MEASURED BOTH WITH AND WITHOUT ADDITIONAL STRESSORS, Annual and Scientific Meeting Virtual Meeting of the Irish Gerontological Society 70 Years of Change 1951-2021 18th November 2021, Online, 2021 Poster, 2021 TARA - Full Text DOI

Romero-Ortuno R, Infection in Dementia and Delirium in Frailty, Nature Aging, 2021 Journal Article, 2021 DOI

Teodoro J. Oscanoa, José Amado, Rawia A. Ghashut, Roman Romero-Ortuno, Relationship between serum 25-hydroxyvitamin D concentration and acute inflammatory markers in hospitalized patients with SARS-CoV-2 infection: a systematic review, Disaster and Emergency Medicine Journal, 2021 Journal Article, 2021 DOI TARA - Full Text

Georgia Richard, Aisling O'Halloran, Paul Doody, Joseph Harbison, Rose Anne Kenny, Roman Romero-Ortuno, Atrial Fibrillation and Acceleration of Frailty: Findings from The Irish Longitudinal Study on Ageing (TILDA), Age and Ageing, 2021 Journal Article, 2021

Roman Romero-Ortuno, Peter Hartley, James Davis, Silvin P. Knight, Rossella Rizzo, Belinda Hernández, Rose Anne Kenny, Aisling M. O'Halloran, Transitions in frailty phenotype states and components over 8 years: evidence from The Irish Longitudinal Study on Ageing, Archives of Gerontology and Geriatrics, 2021 Journal Article, 2021 TARA - Full Text DOI

Teodoro J. Oscanoa, José Amado, Xavier Vidal, Andrea Savarino, Roman Romero-Ortuno, Metformin therapy and severity and mortality of SARS-CoV-2 infection: a meta-analysis, Clinical Diabetology, 2021 Journal Article, 2021 TARA - Full Text DOI

Dee, B., Burke, E., Romero-Ortuno, R., McCallion, P., & McCarron, M., Exploring a Social Conceptualisation of Frailty among Older Adults with an Intellectual Disability, Trinity Health and Education International Research Conference 2021 (THEconf2021): 'Transforming healthcare in a changing world: new ways of thinking and working', Dublin, 9th - 11th March, 2021 Oral Presentation, 2021 URL

Susanne Röhr, Francesca Rodriguez, Rosa Siemensmeyer, Felix Müller, Roman Romero-Ortuno, Steffi G. Riedel-Heller, How can urban environments support dementia risk reduction? A qualitative study, International Journal of Geriatric Psychiatry, 2021 Journal Article, 2021 DOI

James R. Davis, Silvin P. Knight, Orna A. Donoghue, Belinda Hernández, Rossella Rizzo, Rose Anne Kenny, Roman Romero-Ortuno, Comparison of gait speed reserve, usual gait speed, and maximum gait speed of adults aged 50+ in Ireland using explainable machine learning, Frontiers in Network Physiology: Networks in Aging and Frailty, 2021 Journal Article, 2021 URL TARA - Full Text DOI

Kieron Connolly, Conal Cunningham, Niamh Murphy, Roman Romero-Ortuno, Frances Horgan, Prevalence of Sarcopenia and Associated Factors in Older Adults Attending a Day Hospital Service in Ireland, European Geriatric Medicine, 2021 Journal Article, 2021 DOI TARA - Full Text

Román Romero-Ortuño, Nicolás Martínez-Velilla, Richard Sutton, Andrea Ungar, Artur Fedorowski, Rose Galvin, Olga Theou, Andrew Davies, Richard B Reilly, Jurgen Claassen, Áine M Kelly, Plamen Ch. Ivanov, Network Physiology in Aging and Frailty: The Grand Challenge of Physiological Reserve in Older Adults, Frontiers in Network Physiology: Networks in Aging and Frailty, 2021 Journal Article, 2021 DOI TARA - Full Text

Being a frail older person at a time of COVID-19 pandemic in, editor(s)Paulo Oliveira and João Malva , AGING: FROM FUNDAMENTAL BIOLOGY TO SOCIETAL IMPACT, Elsevier, 2021, [Yaohua Chen, Susanne Röhr, Berenice Maria Werle, Roman Romero-Ortuno] Book Chapter, 2021

Rossella Rizzo, Silvin Paul Knight, James Davis, Louise Newman, Eoin Duggan, Rose Anne Kenny, Roman Romero-Ortuno, SART and individual trial mistake thresholds: predictive model for mobility decline, Geriatrics, 2021 Journal Article, 2021 DOI TARA - Full Text

Frailty in, editor(s)Chan Daniel Yam Yin , Chans Practical Geriatrics 4e, Broookvale, N.S.W., BA Printing Services, 2021, [Roman Romero-Ortuno] Book Chapter, 2021 DOI

Teodoro J. Oscanoa, Xavier Vidal, Eliecer Coto, Roman Romero-Ortuno, ACE gene I/D polymorphism and severity of SARS-CoV-2 infection in hospitalized patients: a metanalysis, Arterial Hypertension, 2021 Journal Article, 2021 TARA - Full Text DOI

Dee, B., Burke, E., Romero-Ortuno, R., McCallion, P., and McCarron, M., Social frailty among older adults with an intellectual disability, Journal of Applied Research in Intellectual Disabilities, 6th IASSIDD Europe Congress: Value Diversity, Amsterdam, The Netherlands, 5th - 8th July 2021, 34, (5), Blackwell Publishing LTD, 2021, pp1181 - 1371 Poster, 2021 URL DOI

Tahir Masud, Giulia Ogliari, Eleanor Lunt, Adrian Blundell, Adam Lee Gordon, Regina Roller-Wirnsberger, Michael Vassallo, Daniela Mari, Marina Kotsani, Katrin Singler, Roman Romero-Ortuno, Alfonso Jose Cruz-Jentoft, Andreas Stuck, A scoping review of the changing landscape of Geriatric Medicine in undergraduate medical education: curricula, topics and teaching methods, European Geriatric Medicine, 2021 Journal Article, 2021

Shamik Giri, Lee Minn Chenn, Roman Romero-Ortuno, Nursing homes during the COVID-19 pandemic: a scoping review of challenges and responses, European Geriatric Medicine, 2021 Journal Article, 2021 DOI TARA - Full Text

Y.T. Tang, R. Romero-Ortuno, APPLYING MACHINE LEARNING TO DIFFERENTIATE PREDICTORS OF SYNCOPE, SIMPLE AND COMPLEX FALLS IN THE IRISH LONGITUDINAL STUDY ON AGEING (TILDA), Age and Ageing, Annual and Scientific Meeting Virtual Meeting of the Irish Gerontological Society 70 Years of Change 1951-2021 18th November 2021, Online, 2021 Poster, 2021 DOI TARA - Full Text

Silvin Knight, Louise Newman, John O'Connor, Rose Anne Kenny, Roman Romero-Ortuno, Approximate entropies of resting state continuous neurocardiovascular physiological signals are associated with physical frailty in older adults, Entropy 2021: The Scientific Tool of the 21st Century, Entropy 2021: The Scientific Tool of the 21st Century, Virtual, 5-7 May 2021, 2021 Oral Presentation, 2021 DOI TARA - Full Text

Aisling M. O'Halloran, Peter Hartley, David Moloney, Christine McGarrigle, Rose Anne Kenny, Roman Romero-Ortuno, Informing patterns of health and social care utilisation in Irish older people according to the Clinical Frailty Scale, HRB Open Research, 2021 Journal Article, 2021 DOI

Sebastian Moguilner, Silvin P. Knight, James R.C. Davis, Aisling M. O'Halloran, Rose Anne Kenny, Roman Romero-Ortuno, The Importance of Age in the Prediction of Mortality by a Frailty Index: A Machine Learning Approach in the Irish Longitudinal Study on Ageing, Geriatrics , 6, (3), 2021 Journal Article, 2021 DOI TARA - Full Text URL

Neasa Fitzpatrick, Roman Romero-Ortuno, The Syncope-Falls Index (SYFI): A tool for predicting risk of syncope and complex falls in the older adult based on cumulative health deficits, QJM, 2021 Journal Article, 2021 TARA - Full Text DOI

E. Duggan, S. Knight, R. Rizzo, J.Davis, R.A. Kenny, R. Romero-Ortuño, LONGER CHAIR-STAND TIME IS ASSOCIATED WITH ORTHOSTATIC INTOLERANCE IN AN OLDER IRISH POPULATION, Annual and Scientific Meeting Virtual Meeting of the Irish Gerontological Society 70 Years of Change 1951-2021 18th November 2021, Online, 2021 Poster, 2021 TARA - Full Text DOI

Moloney, D. and Romero-Ortuno, R. and Kenny, R.A., Vasovagal Syncope, JAMA Internal Medicine, 2021 Journal Article, 2021 DOI

S. Knight, R. Boyle, L.Newman, J.Davis, R. Rizzo, E.Duggan, C.De Looze, R. Whelan, R.A. Kenny, R. Romero-Ortuno, HIGHER NEUROVASCULAR SIGNAL ENTROPY IS ASSOCIATED WITH ACCELERATED BRAIN AGEING, Annual and Scientific Meeting Virtual Meeting of the Irish Gerontological Society 70 Years of Change 1951-2021 18th November 2021, Online, 2021 Poster, 2021 DOI TARA - Full Text

Romero-Ortuno, R, Is phenotypical prefrailty all the same? Think again!, British Geriatrics Society Blog, 2020 Report, 2020 DOI

Moloney D, O'Connor J, Newman L, Scarlett S, Hernandez B, Kenny RA, Romero-Ortuno R, Clinical clustering of eight orthostatic haemodynamic patterns in The Irish Longitudinal Study on Ageing (TILDA), Age and Ageing, 2020 Journal Article, 2020 DOI TARA - Full Text

David Moloney, John O'Connor, Louise Newman, Siobhan Scarlett, Belinda Hernandez, Rose Anne Kenny, Roman RomeroOrtuno, Clinical clustering of eight orthostatic haemodynamic patterns in The Irish Longitudinal Study on Ageing (TILDA), European Geriatric Medicine, 16th International E-Congress of the European Geriatric Medicine Society, Virtual , 7-9 October 2020, 11, 2020, ppS117 - S118 Oral Presentation, 2020 DOI

Peeters G, Romero-Ortuno R, Lawlor B, Kenny RA, McHugh Power J, Clustering of behavioural symptoms and their associations with cognitive decline in older adults, JAMDA: Journal of the American Medical Directors Association, 2020 Journal Article, 2020 DOI TARA - Full Text

O'Connor JD, O'Connell MD, Romero-Ortuno R, Hernandez B, Newman L, Reilly R, Kenny RA, Knight SP, Functional Analysis of Continuous, High-Resolution Measures in Ageing Research: A Demonstration using Cerebral Oxygenation Data from The Irish Longitudinal Study on Ageing, Frontiers in Human Neuroscience, section Cognitive Neuroscience, 2020 Journal Article, 2020 TARA - Full Text DOI

Íde O'Shaughnessy, Roman Romero-Ortuno, Lucinda Edge, Aoife Dillon, Sinéad Flynn, Robert Briggs, Darragh Shields, Geraldine McMahon, Arthur Hennessy, Una Kennedy, Paul Staunton, Rosa McNamara, Suzanne Timmons, Frances Horgan, Conal Cunningham, Home FIRsT: interdisciplinary geriatric assessment and disposition outcomes in the Emergency Department, European Journal of Internal Medicine, 2020 Journal Article, 2020 DOI TARA - Full Text

Teodoro J. Oscanoa, Xavier Vidal, Jørgen K. Kanters, Roman Romero-Ortuno, Frequency of Long QT in Patients with SARS-CoV-2 Infection Treated with Hydroxychloroquine: a Meta-analysis, International Journal of Antimicrobial Agents, 2020 Journal Article, 2020 TARA - Full Text DOI

Chen Y, Dominguez-Vivero C, Almirall-Sanchez A, Oz D, Romero-Ortuno R, Hospital-associated deconditioning: brain health issues beyond physical factors, Alzheimer's Association International Conference (AAIC) 2020, Virtual, 2020 Poster, 2020 DOI

Fiachra Maguire, Roman Romero-Ortuno, John D O'Connor, Richard B Reilly, Silvin P Knight, Rose-Anne Kenny, One-dimensional statistical parametric mapping identifies impaired orthostatic cerebrovascular and cardiovascular response in frailty index, The Journals of Gerontology, Series A Medical Sciences, 2020 Journal Article, 2020 TARA - Full Text DOI

Teodoro J. Oscanoa, Edwin C. Cieza, Frank A. Lizaraso-Soto, María L. Guevara, Ricardo M. Fujita, Roman Romero-Ortuno, LACK OF ASSOCIATION BETWEEN ANGIOTENSIN-CONVERTING ENZYME (ACE) GENOTYPE AND ESSENTIAL HYPERTENSION IN PERUVIAN OLDER PEOPLE, Arterial Hypertension, 2020 Journal Article, 2020 DOI TARA - Full Text

V.L. KEEVIL, A. LIOU, L. VAN DER POEL, S. WALLIS, R. ROMERO-ORTUNO, R. BIRAM, EMERGENCY HOSPITAL ADMISSIONS IN OLDER ADULTS FROM RESIDENTIAL AND NURSING HOMES: FREQUENCY, CHARACTERISTICS AND OUTCOMES, The Journal of Nursing Home Research Sciences, 2020 Journal Article, 2020 DOI

Oscanoa, T.J. and Cieza, E.C. and Lizaraso-Soto, F.A. and Guevara, M.L. and Fujita, R.M. and Romero-Ortuno, R., Lack of association between angiotensin-converting enzyme (ACE) genotype and essential hypertension in Peruvian older people, Arterial Hypertension (Poland), 24, (3), 2020, p115-119 Journal Article, 2020 DOI

Knight, S.P.; Newman, L.; O'Connor, J.D.; Davis, J.; Kenny, R.A.; Romero-Ortuno, R., Associations between frailty phenotype and cardiovascular / neurovascular signal complexity, SFI Summit 2020, Virtual , 2020 Oral Presentation, 2020 DOI

Teodoro J. Oscanoa, Edwin C. Cieza, Frank A. Lizaraso-Soto, María L. Guevara, Ricardo M. Fujita, Román Romero-Ortuño, ANGIOTENSIN-CONVERTING ENZYME (ACE) GENETIC VARIATION AND LONGEVITY IN PERUVIAN OLDER PEOPLE: A CROSS-SECTIONAL STUDY, Annals of Human Biology, 2020 Journal Article, 2020 TARA - Full Text DOI

Dee, B., Burke, E., Romero-Ortuno, R., McCallion, P., & McCarron, M., Factors associated with frailty among older adults with an intellectual disability: a systematic review of the literature, Trinity Health and Education International Research Conference: Integrated Health Care Developing Integrated Person-Centered Health Systems, TheConfo2020, Dublin, 3rd - 5th March, 2020 Oral Presentation, 2020 URL

Oscanoa TJ, Romero-Ortuno R, Carvajal A, Savarino A, A pharmacological perspective of Chloroquine in SARS-CoV-2 infection, International Journal of Antimicrobial Agents, 2020 Journal Article, 2020 TARA - Full Text DOI

Macdonald S H-F, Travers J, Ní Shé É, Bailey J, Romero-Ortuno R, Keyes M, O'Shea D, Cooney MT, Primary care interventions to address physical frailty among community-dwelling adults aged 60 years or older: A meta-analysis, PLOS ONE, 2020 Journal Article, 2020 TARA - Full Text DOI

T.J. Oscanoa, E.C. Cieza, F.A. Lizaraso-Soto, M.L. Guevara, R.M. Fujita, J.F. Parodi, F.M. Runzer-Colmenares, R. Romero-Ortuno, Lack of association between angiotensin-converting enzyme genotype and muscle strength in Peruvian older people, Advances in Gerontology, 2020 Journal Article, 2020 DOI TARA - Full Text

Evans NR, Wall J, To B, Wallis SJ, Romero-Ortuno R, Warburton EA, Clinical frailty independently predicts early mortality after ischaemic stroke, Age and Ageing, 2020 Journal Article, 2020 TARA - Full Text DOI

Hartley P, Romero-Ortuno R, Wellwood I, Deaton C, Changes in Muscle Strength and Physical Function in Older Patients During and After Hospitalisation: a Prospective Repeated-Measures Cohort Study, Age and Ageing, 2020 Journal Article, 2020 TARA - Full Text DOI

Oscanoa, T.J. and Cieza, E.C. and Lizaraso-Soto, F.A. and Guevara, M.L. and Fujita, R.M. and Romero-Ortuño, R., Angiotensin-Converting Enzyme (ACE) genetic variation and longevity in Peruvian older people: a cross-sectional study, Annals of Human Biology, 47, (3), 2020, p309-312 Journal Article, 2020 DOI

Oscanoa, T.J. and Vidal, X. and Carvajal, A. and Amado, J. and Romero-Ortuno, R., Severity of SARS-COV-2 infection and angiotensin converting enzyme inhibitors and angiotensin receptor blockers: A meta-analysis, Arterial Hypertension (Poland), 24, (3), 2020, p106-114 Journal Article, 2020 DOI

Oscanoa, T.J. and Romero-Ortuno, R. and Carvajal, A. and Savarino, A., A pharmacological perspective of chloroquine in SARS-CoV-2 infection: An old drug for the fight against a new coronavirus?, International Journal of Antimicrobial Agents, 56, (3), 2020 Journal Article, 2020 DOI

McCarthy K, Ward M, Romero-Ortuno R, Kenny RA, Syncope, fear of falling and quality of life among older adults: findings from The Irish Longitudinal Study on Ageing (TILDA), Frontiers in Cardiovascular Medicine, 2020 Journal Article, 2020 DOI TARA - Full Text

David Moloney, Roman Romero-Ortuno, Rose Anne Kenny, Letter to the editor in reponse to 'An Atypical Case of Vasovagal Cardioinhibitory Syncope in a Young Male Soldier-Stand Up, Be Counted. Doman, E.R., A.J. Kisling, and E. Fentanes, JAMA Internal Medicine, 2020', JAMA Internal Medicine, 2020 Journal Article, 2020 DOI

Hartley P, Dewitt AL, Forsyth F, Romero-Ortuno R, Deaton C, Predictors of physical activity in older adults early in an emergency hospital admission: a prospective cohort study, BMC Geriatrics, 2020 Journal Article, 2020 TARA - Full Text DOI

Teodoro J. Oscanoa, Xavier Vidal, Alfonso Carvajal, José Amado, Roman Romero-Ortuno, SEVERITY OF SARS-COV-2 INFECTION AND ANGIOTENSIN‐CONVERTING ENZYME INHIBITORS AND ANGIOTENSIN RECEPTOR BLOCKERS: A META-ANALYSIS, Arterial Hypertension, 2020 Journal Article, 2020 TARA - Full Text DOI

Travers, J. Romero-Ortuno, R. Power, D. Doran, P. Langan, J. MacNamara, F. McCormack, D. McDermott, C. McEntire, J. McKiernan, J. Vencken, S. Murphy, A. W. Murphy, P. J. Ní Shé, É O'Shea, D. Cooney, M. T., Protocol for a randomised controlled trial of a primary care intervention to Reverse Frailty and Enhance Resilience through Exercise and dietary protein Education (REFEREE) in community-dwelling adults aged 65 and over, HRB Open Research, 2020 Journal Article, 2020 DOI TARA - Full Text

Rónán O'Caoimh, Siobhán Kennelly, Emer Ahern, Shaun O'Keeffe, Román Romero Ortuño, Covid-19 and the challenges of frailty screening in older adults, Journal of Frailty and Ageing, 2020 Journal Article, 2020 DOI TARA - Full Text

Chintapalli R, Romero-Ortuno R, Choice reaction time and subsequent mobility decline: Prospective observational findings from The Irish Longitudinal Study on Ageing (TILDA), Lancet EClinicalMedicine, 2020 Journal Article, 2020 TARA - Full Text DOI

Oscanoa TJ, Amado J, Vidal X, Romero-Ortuno R, Angiotensin-Receptor Blockers (ARBs) and risk of Alzheimer's Disease: A meta-analysis, Current Clinical Pharmacology, 2020 Journal Article, 2020 DOI

Martin F, Romero-Ortuno R, Longitudinal studies of ageing: from insights to impacts: Commentary to accompany themed collection on longitudinal studies, Age and Ageing, 2019 Journal Article, 2019 TARA - Full Text DOI

Romero-Ortuno R, Scarlett S, O'Halloran AM, Kenny RA., Is phenotypical prefrailty all the same? A longitudinal investigation of two prefrailty subtypes in TILDA., Age and ageing, 2019 Journal Article, 2019 DOI TARA - Full Text

Mobility and Frailty in, editor(s)Gu D, Dupre M , Encyclopedia of Gerontology and Population Aging, Springer, Cham, 2019, [Hartley P, Romero-Ortuno R] Book Chapter, 2019 DOI

K. M. Torsney, R. Romero-Ortuno, A SERVICE EVALUATION OF THE PERFORMANCE OF THE 4- AT AS A COGNITIVE SCREENING TOOL IN AN ENGLISH UNIVERSITY HOSPITAL, Age and Ageing, British Geriatrics Society Communications to the Autumn Meeting, London, 14-16 November 2018, 48, (Supplement_1), 2019 Poster, 2019 DOI

Rivasi G, Kenny RA, Ungar A, Romero-Ortuno R, Effects of benzodiazepines on orthostatic blood pressure in older people, European Journal of Internal Medicine, 2019 Journal Article, 2019 DOI

Louise Lafortune, Joyce Coker, Rhian Simpson, Roman Romero-Ortuno, FRAILTY PROFILES: AN ANALYSIS OF ROUTINELY COLLECTED HOSPITAL DATA, The Journal of Frailty & Aging, 9th International Conference on Frailty & Sarcopenia Research (ICFSR) , Miami, USA, February 20-22, 2019, 2019 Poster, 2019 DOI

Rivasi G, Kenny RA, Ungar A, Romero-Ortuno R, Predictors of incident fear of falling in community-dwelling older adults, Journal of the American Medical Directors Association, 2019 Journal Article, 2019 DOI

Romero-Ortuno R, Scarlett S, O'Halloran A, Kenny RA, Is phenotypical prefrailty all the same? A longitudinal investigation of two prefrailty subtypes in The Irish Longitudinal Study of Ageing (TILDA), Age and Ageing, 2019 Journal Article, 2019 DOI

Duggan E, Romero-Ortuno R, Kenny RA, Admissions for Orthostatic Hypotension: an Analysis of NHS England Hospital Episode Statistics Data, BMJ Open, 2019 Journal Article, 2019 DOI TARA - Full Text

Lyons A, Romero-Ortuno R, Hartley P, Functional Mobility Trajectories of Hospitalized Older Adults Admitted to the Acute Geriatric Wards: A Retrospective Observational Study in an English University Hospital, Geriatrics and Gerontology International, 2019 Journal Article, 2019 DOI TARA - Full Text

Teodoro J Oscanoa, Irene Andia M, Ociela Grimaldo, Edwin Cieza M, Frank Lizaraso Soto, Roman Romero Ortuno and Ricardo Fujita, Use of angiotensin II receptor blockers (ARBs), angiotensin I-converting enzyme (ACE) polymorphism and associations with memory performance in older people, Journal of Neurology & Neurophysiology, 2019 Journal Article, 2019 URL

Romero-Ortuno R, Kenny RA, McManus R, Collagens and elastin genetic variations and their potential role in aging-related diseases and longevity in humans, Experimental Gerontology, 129, 2019, p110781 - Journal Article, 2019 DOI URL

Dent, E. and Martin, F.C. and Bergman, H. and Woo, J. and Romero-Ortuno, R. and Walston, J.D., Management of frailty: opportunities, challenges, and future directions, The Lancet, 394, (10206), 2019, p1376-1386 Journal Article, 2019 DOI

Hartley P, Costello P, Fenner R, Gibbins N, Quinn E, Kuhn I, Keevil VL, Romero-Ortuno R, Change in skeletal muscle associated with unplanned hospital admissions in adult patients: a systematic review and meta-analysis, PLOS One, 2019 Journal Article, 2019 DOI TARA - Full Text

Dent E, Martin FC, Bergman H, Woo J, Romero-Ortuno R, Walston J, The Management of Frailty: Opportunities, Challenges, and Future Directions, The Lancet, 2019 Journal Article, 2019 DOI

Frailty in older persons in, editor(s)O'Hanlon S, Smith M , A Comprehensive Guide to Rehabilitation of the Older Patient 4e, Elsevier, 2019, [Roe L, Williamson W, Romero-Ortuno R] Book Chapter, 2019 DOI

Pickard S, Lloyd L, Vanhoutte B, Danely J, Leon-Salas J, Laceulle H, Cluley V, Romero-Ortuno R, New Horizons in Frailty: the contingent, the existential and the clinical, Age and Ageing, 2019 Journal Article, 2019 DOI TARA - Full Text

Hartley P, Keevil VL, Westgate K, White T, Brage S, Romero-Ortuno R, Deaton C, Using Accelerometers to Measure Physical Activity in Older Patients Admitted to Hospital, Current Gerontology and Geriatrics Research, 2018 Journal Article, 2018 DOI

O'Connell, M.D. and Savva, G.M. and Finucane, C. and Romero-Ortuno, R. and Fan, C.W. and Kenny, R.A., Impairments in Hemodynamic Responses to Orthostasis Associated with Frailty: Results from The Irish Longitudinal Study on Ageing (TILDA), Journal of the American Geriatrics Society, 66, (9), 2018, p1475-1483 Journal Article, 2018 TARA - Full Text DOI

Torsney KM, Romero-Ortuno R, The Clinical Frailty Scale predicts inpatient mortality in older hospitalised patients with idiopathic Parkinson's disease, The Journal of the Royal College of Physicians of Edinburgh, 48, (2), 2018, p103 - 107 Journal Article, 2018 DOI TARA - Full Text

Oscanoa TJ, Amado JP, Romero-Ortuno R, Hidalgo JA, Estimation of the glomerular filtration rate in older individuals with serum creatinine-based equations: A systematic comparison between CKD-EPI and BIS1, Archives of Gerontology and Geriatrics , 75, 2018, p139 - 145 Journal Article, 2018 DOI

Alabaf Sabbaghi S, De Souza D, Sarikonda P, Keevil VL, Wallis SJ, Romero-Ortuno R, Allocating patients to geriatric medicine wards in a tertiary university hospital in England: A service evaluation of the Specialist Advice for the Frail Elderly (SAFE) team, Aging Medicine, 2018, p1 - 5 Journal Article, 2018 DOI

Moore G, Hartley P, Romero-Ortuno R, Health and social factors associated with a delayed discharge amongst inpatients in acute geriatric wards: A retrospective observational study, Geriatrics and Gerontology International, 18, (4), 2018, p530 - 537 Journal Article, 2018 TARA - Full Text DOI

Stubbs D, Bowen J, Murray R, Gilder F, Romero-Ortuno R, Biram R, Menon D, Ercole A, Development and validation of an electronic postoperative morbidity score (EPOMS), Anesthesia & Analgesia, 2018 Journal Article, 2018 TARA - Full Text DOI

Romero-Ortuno R, Forsyth DR, Frailty, the determinants of health and the new evidence base, Aging Medicine, 2018, p1 - 2 Journal Article, 2018 DOI

Amblàs-Novellas J, Martori JC, Espaulella J, Oller R, Molist-Brunet N, Inzitari M, Romero-Ortuno R , Frail-VIG index: a concise frailty evaluation tool for rapid geriatric assessment, BMC Geriatrics , 18, 2018, p29- Journal Article, 2018 TARA - Full Text DOI

Keevil VL, Martin GJ, Biram R, Wallis S, Romero-Ortuno R, Care home residents admitted to hospital through the emergency pathway: characteristics and associations with inpatient mortality, Journal of the Royal College of Physicians of Edinburgh, 48, 2018, p202 - 209 Journal Article, 2018 TARA - Full Text DOI

Travers J., Romero-Ortuno R., Bailey J., Cooney M.T., Delaying and reversing frailty: a systematic review of primary care interventions, British Journal of General Practice, 2018 Journal Article, 2018 DOI TARA - Full Text

Weichert I, Romero-Ortuno R, Tolonen J, Soe T, Lebus C, Choudhury S, Nadarajah CV, NAnayakkara P, Orru M, Di Somma S, Anticholinergic medications in patients admitted with cognitive impairment and falls (AMiCI). The impact of hospital admission on anticholinergic cognitive medication burden. Results of a multi centre observational study, Journal of Clinical Pharmacy and Therapeutics, 43, (5), 2018, p682 - 694 Journal Article, 2018 TARA - Full Text DOI

Torsney, K.M. and Romero-Ortuno, R., The clinical frailty scale predicts inpatient mortality in older hospitalised patients with idiopathic parkinson†s disease, Journal of the Royal College of Physicians of Edinburgh, 48, (2), 2018, p103-107 Journal Article, 2018 DOI

Romero-Ortuno R, Forsyth DR, Wilson KJ, Cameron E, Wallis S, Biram R, Keevil VL, The association of geriatric syndromes with hospital outcomes, Journal of Hospital Medicine , 12, (2), 2017, p83 - 89 Journal Article, 2017 TARA - Full Text

Hartley P, Alexander K, Adamson J, Cunningham C, Embleton G, Romero-Ortuno R, Association of cognition with functional trajectories in patients admitted to geriatric wards: a retrospective observational study, Geriatrics and Gerontology International , 17, (10), 2017, p1438 - 1443 Journal Article, 2017 TARA - Full Text

Amblàs-Novellas J, Espaulella-Panicot J, Inzitari M, Rexach L, Fontecha B, Romero-Ortuno R, The challenge of clinical complexity in the 21st century: could frailty indices be the answer?, Spanish Journal of Geriatrics and Gerontology, 52, (3), 2017, p159 - 166 Journal Article, 2017

Hartley PJ, Keevil VL, Alushi L, Charles RL, Conroy EB, Costello PM, Dixon B, Dolinska-Grzybek AM, Vajda D, Romero-Ortuno R, Earlier physical therapy input is associated with a reduced length of hospital stay and reduced care needs on discharge in frail older inpatients: an observational study, Journal of Geriatric Physical Therapy , 2017 Journal Article, 2017 TARA - Full Text

Hartley P, Keevil VL, Romero-Ortuno R, The association between clinical frailty and walking speed in older hospitalised medical patients: a retrospective observational study, European Geriatric Medicine , 8, (2), 2017, p130 - 133 Journal Article, 2017 TARA - Full Text

Hartley P, Gibbins N, Saunders A, Alexander K, Conroy E, Dixon R, Lang J, Luckett J, Luddington T, Romero-Ortuno R, The association between cognitive impairment and functional outcome in hospitalised older patients: a systematic review and meta-analysis, Age and Ageing , 46, (4), 2017, p559 - 567 Journal Article, 2017 TARA - Full Text

Hartley P, Adamson J, Cunningham C, Embleton G, Romero-Ortuno R, Clinical frailty and functional trajectories in hospitalized older adults: a retrospective observational study, Geriatrics and Gerontology International , 17, (7), 2017, p1063 - 1068 Journal Article, 2017 TARA - Full Text

Contra-Carné A, Romero-Ortuno R, Frailty screening in the acute hospital: evidence and challenges based on an English experience, Revista Multidisciplinar de Gerontología , 22, 2017 Journal Article, 2017

Amblàs-Novellas, J. and Espaulella-Panicot, J. and Inzitari, M. and Rexach, L. and Fontecha, B. and Romero-Ortuno, R., The challenge of clinical complexity in the 21st century: Could frailty indexes be the answer? [En busca de respuestas al reto de la complejidad clínica en el siglo XXI: a propósito de los índices de fragilidad], Revista Espanola de Geriatria y Gerontologia, 52, (3), 2017, p159-166 Journal Article, 2017 DOI

Induruwa IP, Evans NR, Aziz A, Reddy S, Khadjooi K, Romero-Ortuno R, Clinical frailty is independently associated with non-prescription of anticoagulants in older patients with atrial fibrillation, Geriatrics and Gerontology International , 17, (11), 2017, p2178 - 2183 Journal Article, 2017 DOI TARA - Full Text

Kenny R.A, Romero-Ortuno R, Kumar P, Falls in older adults, Medicine (United Kingdom), 45, (1), 2017, p28 - 33 Journal Article, 2017 DOI URL

Disorders of the Autonomic Nervous System (Chapter 63) in, editor(s)Fillit HM, Rockwood K, Woodhouse K , Brocklehurst's Textbook of Geriatric Medicine and Gerontology, 8th Edition, 2016, pp496 - 509, [Romero-Ortuno R, Wilson KJ, Hampton JL] Book Chapter, 2016

Hawker, M., Romero-Ortuno, R., Social Determinants of Discharge Outcomes in Older People Admitted to a Geriatric Medicine Ward, The Journal of frailty & aging, 5, (2), 2016, p118-120 Journal Article, 2016

Oscanoa, T., Romero-Ortuno, R., Cruz-Jentoft, A., Negative stereotypes associated with frailty in the elderly, Revista Espanola de Geriatria y Gerontologia, 2016 Journal Article, 2016

Hartley, P., Adamson, J., Cunningham, C., Embleton, G., Romero-Ortuno, R., Higher Physiotherapy Frequency Is Associated with Shorter Length of Stay and Greater Functional Recovery in Hospitalized Frail Older Adults: A Retrospective Observational Study, The Journal of frailty & aging, 5, (2), 2016, p121-125 Journal Article, 2016

Oscanoa, T. and Romero-Ortuno, R. and Cruz-Jentoft, A., Negative stereotypes associated with frailty in the elderly [Estereotipos negativos asociados a la fragilidad en personas mayores], Revista Espanola de Geriatria y Gerontologia, 51, (4), 2016, p225-228 Journal Article, 2016 DOI

Fleming, J., Farquhar, M., Brayne, C., Barclay, S., Buck, J., Dening, T., Hunter, S., Mukaetova-Ladinska, E., O'Sullivan, A., Paykel, E., Romero-Ortuno, R., Zhao, J.E., Death and the oldest old: Attitudes and preferences for end-of-life care - Qualitative research within a population-based cohort study, PLoS ONE, 11, (4), 2016 Journal Article, 2016

Romero-Ortuno R, Wallis S, Biram R, Keevil VL, Clinical frailty adds to acute illness severity in predicting mortality in hospitalised older adults: an observational study, European Journal of Internal Medicine, 35, 2016, p24 - 34 Journal Article, 2016

Wallis SJ, Wall J, Biram RW, Romero-Ortuno R, Association of the clinical frailty scale with hospital outcomes., QJM : monthly journal of the Association of Physicians, 108, (12), 2015, p943-9 Journal Article, 2015 DOI

Chan DKY, Srinivasan V, Upton C, Chen X, Romero-Ortuno R, The association between frailty and vascular dementia, Chinese Journal of Geriatrics , 34, (12), 2015, p1293 - 1299 Journal Article, 2015

Keevil VL, Romero-Ortuno R, Ageing well: a review of sarcopenia and frailty., The Proceedings of the Nutrition Society, 74, (4), 2015, p337-47 Journal Article, 2015 DOI

Romero-Ortuno R1, O'Connell MD, Finucane C, Fan CW, Kenny RA, Higher orthostatic heart rate predicts mortality: The Irish Longitudinal Study on Ageing (TILDA), Aging Clin Exp Res, 27, (2), 2015, p239-242 Journal Article, 2015 DOI

Romero-Ortuno R, Frailty in Primary Care., Interdisciplinary topics in gerontology and geriatrics, 41, 2015, p85-94 Journal Article, 2015 DOI

Martínez-Velilla, N., Romero-Ortuño, R., Frailty: Yes, but let's avoid 'frailtism' | Fragilidad: Sí, pero evitemos el «fragilismo», Revista Espanola de Geriatria y Gerontologia, 50, (5), 2015, p209-210 Journal Article, 2015

Romero-Ortuno R, Fouweather T, Jagger C, Cross-national disparities in sex differences in life expectancy with and without frailty., Age and ageing, 43, (2), 2014, p222-8 Journal Article, 2014 DOI TARA - Full Text

Romero-Ortuno, R., O'Dwyer, C., Byrne, D., O'Riordan, D., Silke, B., A Risk Index for Geriatric Acute Medical Admissions (RIGAMA), Acute Med, 13, (1), 2014, p6-11 Journal Article, 2014

Grace AR, Briggs R, Kieran RE, Corcoran RM, Romero-Ortuno R, Coughlan TL, O'Neill D, Collins R, Kennelly SP, A Comparison of Beers and STOPP Criteria in Assessing Potentially Inappropriate Medications in Nursing Home Residents Attending the Emergency Department., Journal of the American Medical Directors Association, 2014 Journal Article, 2014 TARA - Full Text DOI

BMC Geriatrics, BMC, [Associate Editor (public health, nutrition and epidemiology)], 2014-2019 Editorial Board, 2014 URL

Ntlholang O, Kelly RE, Romero-Ortuno R, Cosgrave S, Kelly D, Crowe M, Collins O, Barry JJ, Cogan L, Hughes G, O'Shea D, The role the frailty syndrome can play in advocacy and resource allocation for our ageing population - findings in a Dublin day hospital, The Journal of Frailty and Aging, 3, (1), 2014, p21 - 24 Journal Article, 2014

Kennelly SP, Drumm B, Coughlan T, Collins R, O'Neill D, Romero-Ortuno R, Characteristics and outcomes of older persons attending the emergency department: a retrospective cohort study., QJM, 2014 Journal Article, 2014 DOI TARA - Full Text

Romero-Ortuno R, Frailty Index in Europeans: association with determinants of health., Geriatrics & gerontology international, 14, (2), 2014, p420-9 Journal Article, 2014 DOI TARA - Full Text

Romero-Ortuno R, Tiernan C, Cogan L, The impact of frailty on post-acute rehabilitation outcomes in older adults, The Journal of Frailty and Aging , 3, (4), 2014, p234 - 237 Journal Article, 2014

Romero-Ortuno R, Soraghan C, A Frailty Instrument for primary care for those aged 75 years or more: findings from the Survey of Health, Ageing and Retirement in Europe, a longitudinal population-based cohort study (SHARE-FI75+)., BMJ open, 4, (12), 2014, pe006645 Journal Article, 2014 TARA - Full Text DOI

Reynaud C, McHugh T, Romero-Ortuno R, Frailty: what does it mean for clinical care provision? , Scottish Universities Medical Journal , 3, (1), 2014, p54 - 64 Journal Article, 2014

Romero-Ortuno R, An alternative method for Frailty Index cut-off points to define frailty categories., European geriatric medicine, 4, (5), 2013 Journal Article, 2013 DOI TARA - Full Text

Kenny, R.A., Romero-Ortuno, R., Cogan, L, Falls, Medicine, 41, (3), 2013, p155-159 Journal Article, 2013 DOI

Romero-Ortuno, R., O'Shea, D., Fitness and frailty: Opposite ends of a challenging continuum! Will the end of age discrimination make frailty assessments an imperative?, 42, (3), 2013, p279-280 Journal Article, 2013

Romero-Ortuno R, The Frailty Instrument for primary care of the Survey of Health, Ageing and Retirement in Europe predicts mortality similarly to a frailty index based on comprehensive geriatric assessment., Geriatrics & gerontology international, 13, (2), 2013, p497-504 Journal Article, 2013 DOI TARA - Full Text

Romero-Ortuno, R, O'Connell, MDL, Finucane, C, Soraghan, C, Fan, CW, Kenny, RA, Insights into the clinical management of the syndrome of supine hypertension - orthostatic hypotension (SH-OH): The Irish Longitudinal Study on Ageing (TILDA), BMC Geriatrics, 13, 2013, p73- Journal Article, 2013 DOI TARA - Full Text

Romero Ortuño, R., Formiga, F., Fitness or frailty? Does age matter? New horizons in geriatrics | "Fortaleza o fragilidad? "Importa la edad? Nuevos horizontes en geriatría, 48, (5), 2013, p207-208 Journal Article, 2013

Romero-Ortuno R, The SHARE operationalized frailty phenotype: a comparison of two approaches., European geriatric medicine, 4, (4), 2013 Journal Article, 2013 DOI TARA - Full Text

Romero-Ortuno, R., Silke, B., Use of a laboratory only score system to define trajectories and outcomes of older people admitted to the acute hospital as medical emergencies, 13, (2), 2013, p405-412 Journal Article, 2013

Romero-Ortuno, R., Tempany, M., Dennis, L., O'Riordan, D., Silke, B., Deprivation in cold weather increases the risk of hospital admission with hypothermia in older people, 182, (3), 2013, p513-518 Journal Article, 2013

Back to basics or into a brave new world? The potential and pitfalls of biomarkers in explaining the pathways between social engagement and health in, editor(s)Hoque, N., McGehee, M.A. and Bradshaw, B.S. (eds) , Applied demography and public health [Applied demography series volume 3], New York, Springer, 2013, pp313 - 336, [Kamiya, Y., Timonen, V., Romero-Ortuno, R. and Kenny, R.A.] Book Chapter, 2013

Ni Mhaolain AM, Fan CW, Romero-Ortuno R, Cogan L, Cunningham C, Kenny RA, Lawlor B., Frailty, depression and anxiety in later life., International Psychogeriatrics, 24, (8), 2012, p1265 - 1274 Journal Article, 2012 DOI TARA - Full Text

Romero-Ortuno, R., O'Shea, D., Silke, B., Predicting the in-patient outcomes of acute medical admissions from the nursing home: The experience of St James's Hospital, Dublin, 2002-2010, 12, (4), 2012, p703-713 Journal Article, 2012

Romero-Ortuno, R., O'Riordan, D., Silke, B., Profiling the medical admissions of the homeless, 11, (4), 2012, p197-204 Journal Article, 2012

Romero-Ortuno, R., O'Shea, D., Aspirin versus warfarin in atrial fibrillation: Decision analysis may help patients' choice, 41, (2), 2012, p250-254 Journal Article, 2012

Romero-Ortuno R, Kenny RA., The frailty index in Europeans: association with age and mortality., Age and Ageing, afs051, 2012, p684-689 Journal Article, 2012 DOI TARA - Full Text

Romero-Ortuno R, Kenny RA., The frailty index in Europeans: assocation with age and mortality., Age Ageing, 41, (Sep), 2012, p684 - 689 Journal Article, 2012 TARA - Full Text DOI

Ni Mhaolain AM, Fan CW, Romero-Ortuno R, Cogan L, Cunningham C, Lawlor B, Kenny RA., Depression: a modifiable factor in fearful older fallers transitioning to frailty?, International Journal of Geriatric Psychiatry , 27, (7), 2012, p727 - 733 Journal Article, 2012 DOI

Romero-Ortuno R, Casey AM, Cunningham CU, Squires S, Prendergast D, Kenny RA, Lawlor BA, Psychosocial and functional correlates of nutrition among community-dwelling older adults in Ireland, Journal of Nutrition, Health and Aging , 15, (7), 2011, p527-531 Journal Article, 2011 DOI

Romero-Ortuno R, O'Shea D, Kenny RA., The SHARE frailty instrument for primary care predicts incident disability in a European population-based sample., Quality in Primary Care , 19, (5), 2011, p301 - 309 Journal Article, 2011 URL

Romero-Ortuno R, Cogan L, Browne J, Healy M, Casey MC, Cunningham C, Walsh JB, Kenny RA, Seasonal variation of serum vitamin D and the effect of vitamin D supplementation in Irish community-dwelling older people., Age and ageing, 40, (2), 2011, p168-74 Journal Article, 2011 DOI TARA - Full Text

Romero-Ortuno R, Cogan L, O'Shea D, Lawlor BA, Kenny RA, Orthostatic haemodynamics may be impaired in frailty., Age and Ageing, 40, (5), 2011, p576-83 Journal Article, 2011 DOI TARA - Full Text

R Romero-Ortuno, L Cogan, T Foran, RA Kenny, CW Fan., Continuous noninvasive orthostatic blood pressure measurements and their relationship with orthostatic intolerance, falls, and frailty in older people., Journal of the American Geriatrics Society, 59, (4), 2011, p655-65 Journal Article, 2011 TARA - Full Text

Romero-Ortuno, R., The frailty instrument of the survey of health, ageing and retirement in Europe (SHARE-FI) predicts mortality beyond age, comorbidities, disability, self-rated health, education and depression, 2, (6), 2011, p323-326 Journal Article, 2011

Romero Ortuño, R., The Frailty Instrument for primary care of the Survey of Health, Ageing and Retirement in Europe (SHARE-FI): Results of the Spanish sample | El Instrumento de Fragilidad para Atención Primaria de la Encuesta de Salud, Envejecimiento y Jubilación en Europa (SHARE-FI): resultados de la muestra española, 46, (5), 2011, p243-249 Journal Article, 2011

Romero-Ortuno, R, Cogan, L, Foran, T, Fan, CW, Kenny, RA, Using the Finometer to examine sex differences in hemodynamic responses to orthostasis in older people, BLOOD PRESSURE MONITORING, 15, 2010 Journal Article, 2010

Romero-Ortuno, R., Walsh, C.D., Lawlor, B.A., Kenny, R.A., A Frailty Instrument for primary care: Findings from the Survey of Health, Ageing and Retirement in Europe (SHARE), BMC Geriatrics, 10, 2010 Journal Article, 2010 DOI

Romero-Ortuno R, Cogan L, Fan CW, Kenny RA., Intolerance to initial orthostasis relates to systolic BP changes in elders., Clin Auton Res., 20, (1), 2010, p39 - 45 Journal Article, 2010

Romero-Ortuno, R, Cogan, L, Cunningham, CU, Kenny, RA, Do older pedestrians have enough time to cross roads in Dublin? A critique of the Traffic Management Guidelines based on clinical research findings, AGE AND AGEING, 39, 2010 Journal Article, 2010

Kenny RA, Romero-Ortuno R, Cogan L., Falls., Medicine., 37, (2), 2010, p84 - 87 Journal Article, 2010

Greene BR, O'Donovan A, Romero-Ortuno R, Cogan L, Ni Scannaill C, Kenny RA., Quantitative falls risk assessment using the timed up and go test., IEEE Transactions on Biomedical Engineering., 57, (12), 2010, p2918 - 2926 Journal Article, 2010

Romero Ortuño, R., The regulation of pedestrian traffic lights in Spain: Do older people have enough time to cross the road? | La regulación de los semáforos peatonales en España: "tienen las personas mayores tiempo suficiente para cruzar?, 45, (4), 2010, p199-202 Journal Article, 2010

Romero-Ortuno, R., Frailty: The great confounder, the great forgotten, 96, (7), 2010 Journal Article, 2010

Romero-Ortuno R, Ageing and Social Policy in Ireland, Journal of Social Policy , 38, 2009, p714 - 716 Journal Article, 2009

Romero-Ortuno R, Kenny RA, Is it cardiac? Assessment of syncope with a scoring system., HEART, 94, (12), 2008, p1528 - 1529 Journal Article, 2008 URL

Romero-Ortuno, R. and Noglik, A. and Bassi, Z. and Snelling, S. and Kersnik, J. and O'Conor, R. and O'Farrell, N. and Ash, S. and Fox, P. and Lynn, W., Eligibility of non-residents for NHS treatment [1] (multiple letters), British Medical Journal, 329, (7467), 2004, p683-684 Journal Article, 2004

Romero-Ortuno R, Eligibility of non-residents for NHS treatment: failed asylum seekers should not be denied access to free NHS care., BMJ (Clinical research ed.), 329, (7467), 2004, p683 Journal Article, 2004 DOI

Romero-Ortuño, R., Access to health care for illegal immigrants in the EU: Should we be concerned?, European Journal of Health Law, 11, (3), 2004, p245-272 Journal Article, 2004

Non-Peer-Reviewed Publications

Ann Monaghan, Nollaig Bourke, Aisling O'Halloran, Mark Ward, Feng Xue, Glenn Jennings, Rose Anne Kenny and Roman Romero-Ortuno, New self-reported exhaustion during the COVID-19 Pandemic, TILDA Report, 2021 Report, 2021 DOI TARA - Full Text

Aisling O'Halloran, Roman Romero-Ortuno, How can frailty impact access to health and social care services?, HRB Open Research Blog, November, 2021 Report, 2021 DOI

Roman Romero-Ortuno, Peter May, Minjuan Wang, Siobhan Scarlett, Ann Hever, Rose Anne Kenny, TILDA Nursing Home Data: A short report to inform COVID-19 responses for our most vulnerable, The Irish Longitudinal Study on Ageing, 2020 Report, 2020 DOI

Oscanoa TJ, Vidal X, Carvajal A, Romero-Ortuno R, Renin-angiotensin system inhibitors and severity of SARS-CoV-2 infection: a meta-analysis, Research Square (Preprint), 2020 Journal Article, 2020 DOI

Aisling O'Halloran, Christine McGarrigle, Siobhán Scarlett, Lorna Roe, Mary O'Shea, Roman Romero-Ortuno and Rose Anne Kenny, Living with Frailty in Ireland 2018, TILDA, Trinity College Dublin, 2020 Report, 2020 DOI

Roman Romero-Ortuno, Peter May, Minjuan Wang, Siobhán Scarlett, Ann Hever and Rose Anne Kenny, TILDA Participants in Nursing Homes, TILDA, Trinity College Dublin, 2020 Report, 2020 DOI

Aisling O'Halloran, Christine McGarrigle, Siobhan Scarlett, Lorna Roe, Roman Romero-Ortuno and Rose Anne Kenny, TILDA Report on Population Estimates of Physical Frailty in Ireland to Inform Demographics for Over 50s in Ireland during the COVID-19 Pandemic, Trinity College Dublin, 2020 Report, 2020 DOI

Romero-Ortuño R and Kennelly SP, COVID-19 deaths in Irish Nursing Homes: exploring variation and association with the adherence to national regulatory quality standards, LTCcovid.org, International Long-Term Care Policy Network,, CPEC-LSE, June, 2020 Report, 2020 DOI TARA - Full Text

Research Expertise

Projects

  • Title
    • FRAILMatics: Mathematical research and big data analytics towards the development of the next generation of transdisciplinary diagnostics for the assessment of physiological vulnerability in older adults: challenge-based disruptive technology initiative
  • Summary
    • https://tilda.tcd.ie/frailmatics/ Increasing numbers of older people are living with frailty. Frailty is defined as dysregulation in multiple physiological systems and consequent reduction in physiological reserve. A frail person is vulnerable to decompensate and experience adverse health outcomes in the face of stressors. The higher the number of physiological systems that are dysregulated, the less physiological reserve. Despite consensus in the concept, frailty operationalisations in clinical practice are limited and a universally accepted diagnostic method does not exist. However, there is evidence that early recognition of frailty could prevent or delay adverse outcomes. The Irish Longitudinal Study on Ageing (TILDA) has collected detailed information on real-time functioning of physiological systems, with and without challenge: neurological (choice reaction time, sustained attention to response task, cerebral blood flow before and after standing), cardiovascular (continuous blood pressure and heart rate, before and after standing), and locomotor (gait with and without cognitive challenges). For this research, TILDA will offer the opportunity to host infrastructure and capacity in mining, processing and modelling its largely unexplored complex and computationally expensive "big data". We aim to discover new frailty signals and models, validate them in clinical cohorts, and lead towards new diagnostic tools to help tackle the ageing challenge.
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • 01/12/2019
  • Date To
    • 30/11/2024
  • Title
    • Technology Assisted Solutions for the Recognition of Objective Physiological Indicators of post-COVID-19 Fatigue (TROPIC Study)
  • Summary
    • Many COVID-19 patients are experiencing symptoms consistent with severe fatigue a median of 10 weeks after their initial illness, while almost one-third of those previously employed have not returned to work. At present, most clinical and research measurements of fatigue have relied upon self-reported perception of sensations such as exhaustion or weariness. Using such tools, there is an inherent challenge for clinicians in differentiating between patients who are experiencing fatigue at a psychosocial level, versus those who are actively physiologically and neurocognitively deconditioned.The TROPIC study will use our existing clinical expertise and technology-assisted solutions to address features of post-COVID-19 fatigue by quantifying physiological signatures of adverse sequelae in adult patients previously diagnosed with COVID-19, who are now COVID-19 negative. Our suite of assessments will encompass four systems; physical deconditioning, orthostatic instability, neurocognitive deficits and respiratory sequelae. This will not only inform accurate objective diagnostics of post-COVID-19 Chronic Fatigue Syndrome, but will also guide clinicians in directing the most appropriate therapeutic interventions with maximum efficacy and specificity, bringing not only patient-related but also health system and economic benefits.
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • 1 December 2020
  • Date To
    • 31 January 2021
  • Title
    • FRAIL-INNATE Pilot Study: Investigating the Impact of Frailty on Innate Immune Responses
  • Summary
    • Older adults and those living with frailty (a condition of decreased physiological reserve affecting multiple systems) get higher rates of viral infections, most recently exemplified during the COVID-19 pandemic, where highest mortality is in older individuals and those with severe frailty. Yet older adults and those with frailty are not a homogenous group, and it is still unknown which individuals are most at risk from viral infections and why. There is therefore a fundamental lack of understanding in how increasing age and states of frailty affects anti-viral immunity and how this relates to frailty-associated changes in metabolic health (body composition, energy expenditure) - important influences on anti-viral responses in younger adults, yet remains unexplored in older adults. We hypothesise that by analysing the metabolic status of older adults in different states of frailty, and linking this with how their immune system activates anti-viral immunity, we will reveal crucial insights into anti-viral immunity in older and frail adults. The FRAIL-INNATE Pilot Study builds on the expertise of this clinician-scientist team (Prof. Roman Romero-Ortuno, Dr Nollaig Bourke, Dr Adam Dyer) and will be the first of its kind to address this hypothesis using a standardized method of characterizing innate immune responses in older adults across the frailty spectrum.
  • Funding Agency
    • TTMI Collaborative Pilot Study Awards - Building Engagements in Health Research 2020
  • Date From
    • May 2021
  • Date To
    • May 2023
  • Title
    • NUTRI-AGE: NOVEL DIETARY COMPONENTS IN HEALTHY AGEING
  • Summary
    • The overarching aim of Nutri-Age is to investigate whether higher intakes of alkali-forming compounds present in fruit and vegetables, which are known to attenuate low grade metabolic acidosis, can protect against adverse agerelated changes in skeletal muscle, bone and metabolic health. Objectives: 1) To examine the impact of correcting age-related metabolic acidosis, via nutritional supplementation with the fruit- and vegetable-derived alkaline salt potassium citrate, on skeletal muscle protein synthesis, bone turnover and insulin sensitivity 2) To examine whether diets that are richer in fruit and vegetables (and are therefore lower in dietary acid load and less likely to induce low grade metabolic acidosis) are associated with a slower rate of decline in muscle strength, physical function, frailty status, bone density and glycaemic control in older adults in Ireland. 3) To examine food choice motivation and attitudes towards functional / fortified foods targeted at healthy ageing among older adults via an online survey (Awardee: Dr Caoileann Murphy).
  • Funding Agency
    • Tegasc
  • Date From
    • 18th March 2021
  • Date To
    • 17 March 2024
  • Title
    • Neurocardiovascular instability as a risk factor for progression of Age-related Macular degeneration
  • Summary
    • Age-related macular degeneration (AMD) is the leading cause of vision loss in the over 50's in developed countries accounting for 8.7% of all blindness worldwide. In Ireland alone, ~80,000 people live with this condition. AMD is a progressive disease characterised in early stages by drusen deposition and pigmentary changes, which progresses to late stage geographic atrophy and choroidal neovascularisation. To date, treatment options are limited to late neovascular AMD, while preventative measures such as smoking cessation and increased supplement intake are advised for early and late geographic AMD. Multifactorial in nature, AMD has no defined aetiology, however several environmental and genetic factors have been identified as associated with increased incidence and progression. Neurocardiovascular instability (NCVI) which comprises of age-related changes in blood pressure and heart-rate behaviour manifests as exaggerated blood pressure variability, orthostatic hypotension (OH), orthostatic hypertension (OHTN), and autonomic dysfunction, and has been implicated in cardiovascular risk and associated end-organ damage. Evidence suggests a link between AMD and cardiovascular disease (CVD), with several AMD risk factors also found to be associated with CVD, suggesting that disordered circulation may be a common factor in both conditions. The eye being a highly vascular organ consisting of retinal and choroidal vascular beds, would be vulnerable to NCVI if ocular vasoregulation becomes impaired with age. Indeed, associations between OHTN and BPV and increased AMD risk and poor visual acuity have been established, suggesting the deleterious effect of dysregulated blood pressure behaviour on choroidal circulation may be linked to AMD pathogenesis and progression. In the proposed study we will utilize The Irish Longitudinal study on Ageing (TILDA) dataset to examine measures of visual function and AMD status with cardiovascular/cerebrovascular function and advanced haemodynamic parameters, in this population representative cohort of participants aged ≥50 years, in an effort to establish associations between NCVI and AMD and predictors of AMD progression (Awardee: Dr Emma Connolly).
  • Funding Agency
    • Irish Research Council
  • Date From
    • 1 September 2021
  • Date To
    • 31 August 2023
  • Title
    • A Genome-Wide Association Study (GWAS) of biological age measures in UK Biobank, with a focus on genetic variations of collagens, elastin and pro-inflammatory cytokines
  • Summary
    • https://www.ukbiobank.ac.uk/2019/07/a-genome-wide-association-study-gwas-of-biological-age-measures-in-uk-biobank-with-a-focus-on-genetic-variations-of-collagens-elastin-and-pro-inflammatory-cytokines/
  • Funding Agency
    • Trinity Translational Medicine Institute
  • Date From
    • March 2019
  • Date To
    • December 2020

Keywords

Frailty & Resilience; Gerontology and geriatrics

Recognition

Awards and Honours

President of Ireland Future Research Leaders Award 2018

Count of Cartagena Award of the Royal National Academy of Medicine of Spain 2017

First Prize of the Catalan Society of Geriatrics and Gerontology 2016

British Geriatrics Society Rising Star Award 2015

Elizabeth Brown Prize of the British Geriatrics Society 2010

Trainee Prize, Royal Society of Medicine (Geriatrics and Gerontology Section) 2008

Presidential Medal of the Irish Gerontological Society 2008

Loch Exhibition, University of London 2003

Titmuss Examination Prize (Department of Social Policy, London School of Economics and Political Science) 2003

Memberships

Irish Gerontological Society

Irish Society of Physicians in Geriatric Medicine

Royal College of Physicians of Ireland

Irish Frailty Network for Education, Quality Improvement, Research and Policy

UEMS -Geriatric Medicine section (European Union of Medical Specialists)