Skip to main content

Trinity College Dublin, The University of Dublin

Trinity Menu Trinity Search



You are here Staff

Professor Cliona O'Farrelly
Chair in Comparative Immunology, Biochemistry
Chair in Comparative Immunology, Clinical Medicine

Publications and Further Research Outputs

Peer-Reviewed Publications

Meade, K.G. and O'Farrelly, C., Î'-Defensins: Farming the microbiome for homeostasis and health, Frontiers in Immunology, 10, (JAN), 2019 Journal Article, 2019 DOI TARA - Full Text

Harmon C, Robinson M.W, Hand F, Almuaili D, Mentor K, Houlihan D.D, Hoti E, Lynch L, Geoghegan J, O'Farrelly C, Lactate-Mediated Acidification of Tumor Microenvironment Induces Apoptosis of Liver-Resident NK Cells in Colorectal Liver Metastasis, Cancer immunology research, 7, (2), 2019, p335 - 346 Journal Article, 2019 DOI URL

Kelly, P. and Meade, K.G. and O'Farrelly, C., Non-canonical inflammasome-mediated IL-1β production by primary endometrial epithelial and stromal fibroblast cells is NLRP3 and caspase-4 dependent, Frontiers in Immunology, 10, (FEB), 2019, p1-- Journal Article, 2019 DOI TARA - Full Text

*Galvin KC, *Conroy MJ, Doyle SL, Dunne MR, Fahey R, Foley E, O'Sullivan KE, Doherty DG, Geoghegan JG, Ravi N, O'Farrelly C, Reynolds JV, Lysaght J., Extratumoral PD-1 blockade does not perpetuate obesity-associated inflammation in esophageal adenocarcinoma., Cancer Letters, 418, 2018, p230-238 Journal Article, 2018 URL DOI

Adnane, M. and Kelly, P. and Chapwanya, A. and Meade, K.G. and O'Farrelly, C., Improved detection of biomarkers in cervico-vaginal mucus (CVM) from postpartum cattle, BMC Veterinary Research, 14, (1), 2018 Journal Article, 2018 TARA - Full Text DOI

Gargan, S. and Ahmed, S. and Mahony, R. and Bannan, C. and Napoletano, S. and O'Farrelly, C. and Borrow, P. and Bergin, C. and Stevenson, N.J., HIV-1 Promotes the Degradation of Components of the Type 1 IFN JAK/STAT Pathway and Blocks Anti-viral ISG Induction, EBioMedicine, 30, 2018, p203-216 Journal Article, 2018 DOI TARA - Full Text

Glover, L.E. and Crosby, D. and Thiruchelvam, U. and Harmon, C. and Chorcora, C.N. and Wingfield, M.B. and O'Farrelly, C., Uterine natural killer cell progenitor populations predict successful implantation in women with endometriosis-associated infertility, American Journal of Reproductive Immunology, 2018, pe12817- Journal Article, 2018 DOI

Hall, T.J. and McQuillan, C. and Finlay, E.K. and O'Farrelly, C. and Fair, S. and Meade, K.G., Comparative genomic identification and validation of β-defensin genes in the Ovis aries genome, BMC Genomics, 18, (1), 2017, p278- Journal Article, 2017 DOI TARA - Full Text

Kennelly, K.P. and Holmes, T.M. and Wallace, D.M. and O†Farrelly, C. and Keegan, D.J., Early subretinal allograft rejection is characterized by innate immune activity, Cell Transplantation, 26, (6), 2017, p983-1000 Journal Article, 2017 DOI

Whiston, R. and Finlay, E.K. and McCabe, M.S. and Cormican, P. and Flynn, P. and Cromie, A. and Hansen, P.J. and Lyons, A. and Fair, S. and Lonergan, P. and O'Farrelly, C. and Meade, K.G., A dual targeted β-defensin and exome sequencing approach to identify, validate and functionally characterise genes associated with bull fertility, Scientific Reports, 7, (1), 2017, p12287 - Journal Article, 2017 DOI TARA - Full Text

Mahony R, Gargan S, Roberts KL, Bourke N, Keating SE, Bowie AG, O'Farrelly C, Stevenson NJ, A novel anti-viral role for STAT3 in IFN-alpha signalling responses. , Cellular and Molecular Life Sciences, 74, (9), 2017, p1755 - 1764 Journal Article, 2017 DOI TARA - Full Text

Adnane, M. and Chapwanya, A. and Kaidi, R. and Meade, K.G. and O'Farrelly, C., Profiling inflammatory biomarkers in cervico-vaginal mucus (CVM) postpartum: Potential early indicators of bovine clinical endometritis?, Theriogenology, 103, 2017, p117-122 Journal Article, 2017 DOI

Garvey, P. and Murphy, N. and Flanagan, P. and Brennan, A. and Courtney, G. and Crosbie, O. and Crowe, J. and Hegarty, J. and Lee, J. and McIver, M. and McNulty, C. and Murray, F. and Nolan, N. and O'Farrelly, C. and Stewart, S. and Tait, M. and Norris, S. and Thornton, L., Disease outcomes in a cohort of women in Ireland infected by hepatitis C-contaminated anti-D immunoglobulin during 1970s, Journal of Hepatology, 67, (6), 2017, p1140-1147 Journal Article, 2017 DOI

Conroy M.J, Galvin K.C, Kavanagh M.E, Mongan A.M, Doyle S.L, Gilmartin N, O'Farrelly C, Reynolds J.V, Lysaght J, CCR1 antagonism attenuates T cell trafficking to omentum and liver in obesity-associated cancer, Immunology and Cell Biology, 94, (6), 2016, p531 - 537 Journal Article, 2016 DOI URL

Coughlan A.M, Harmon C, Whelan S, O'Brien E.C, O'Reilly V.P, Crotty P, Kelly P, Ryan M, Hickey F.B, O'Farrelly C, Little M.A, Myeloid engraftment in humanized mice: Impact of granulocyte-colony stimulating factor treatment and transgenic mouse strain, Stem Cells and Development, 25, (7), 2016, p530 - 541 Journal Article, 2016 DOI URL

Harmon C, Sanchez-Fueyo A, O'Farrelly C, Houlihan D.D, Natural Killer Cells and Liver Transplantation: Orchestrators of Rejection or Tolerance?, American Journal of Transplantation, 16, (3), 2016, p751 - 757 Journal Article, 2016 DOI URL

Rush G, O'Donovan A, Nagle L, Conway C, McCrohan A, O'Farrelly C, Lucey J.V, Malone K.M, Alteration of immune markers in a group of melancholic depressed patients and their response to electroconvulsive therapy, Journal of Affective Disorders, 205, 2016, p60 - 68 Journal Article, 2016 URL DOI

Thiruchelvam U, Wingfield M, O'Farrelly C, Increased uNK Progenitor Cells in Women With Endometriosis and Infertility are Associated With Low Levels of Endometrial Stem Cell Factor, American Journal of Reproductive Immunology, 75, (4), 2016, p493 - 502 Journal Article, 2016 DOI URL

Kelly A, Robinson M.W, Roche G, Biron C.A, O'Farrelly C, Ryan E.J, Immune Cell Profiling of IFN-λ Response Shows pDCs Express Highest Level of IFN-λR1 and Are Directly Responsive via the JAK-STAT Pathway, Journal of Interferon and Cytokine Research, 36, (12), 2016, p671 - 680 Journal Article, 2016 URL DOI

Narciandi, F. and Fernandez-Fuertes, B. and Khairulzaman, I. and Jahns, H. and King, D. and Finlay, E.K. and Mok, K.H. and Fair, S. and Lonergan, P. and O'Farrelly, C. and Meade, K.G., Sperm-coating beta-defensin 126 is a dissociation-resistant dimer produced by epididymal epithelium in the bovine reproductive tract, Biology of Reproduction, 95, (6), 2016, p1-9 Journal Article, 2016 DOI

Doherty R, Whiston R, Cormican P, Finlay E.K, Couldrey C, Brady C, O'Farrelly C, Meade K.G, The CD4 + T cell methylome contributes to a distinct CD4 + T cell transcriptional signature in Mycobacterium bovis-infected cattle, Scientific Reports, 6, 2016, p31014 Journal Article, 2016 TARA - Full Text URL DOI

Johnson G.P, Lloyd A.T, O'Farrelly C, Meade K.G, Fair S, Comparative genomic identification and expression profiling of a novel β-defensin gene cluster in the equine reproductive tract, Reproduction, Fertility and Development, 28, (10), 2016, p1499 - 1508 Journal Article, 2016 DOI URL

Conroy M.J, Fitzgerald V, Doyle S.L, Channon S, Useckaite Z, Gilmartin N, O†Farrelly C, Ravi N, Reynolds J.V, Lysaght J, The microenvironment of visceral adipose tissue and liver alter natural killer cell viability and function, Journal of Leukocyte Biology, 100, (6), 2016, p1435 - 1442 Journal Article, 2016 DOI URL

Fischer J, Weber A.N.R, Bohm S, Dickhöfer S, El Maadidi S, Deichsel D, Knop V, Klinker H, Möller B, Rasenack J, Wang L, Sharma M, Hinrichsen H, Spengler U, Buggisch P, Sarrazin C, Pawlita M, Waterboer T, Wiese M, Probst-MÃ"ller E, Malinverni R, Bochud P.-Y, Gardiner C, O'Farrelly C, Berg T, Sex-specific effects of TLR9 promoter variants on spontaneous clearance of HCV infection, Gut, 2016 Journal Article, 2016 URL DOI

Fernandez-Fuertes, B. and Narciandi, F. and O'Farrelly, C. and Kelly, A.K. and Fair, S. and Meade, K.G. and Lonergan, P., Cauda epididymis-specific beta-defensin 126 promotes sperm motility but not fertilizing ability in cattle, Biology of Reproduction, 95, (6), 2016, p1-12 Journal Article, 2016 DOI

Harmon C, Robinson M.W, Fahey R, Whelan S, Houlihan D.D, Geoghegan J, O'Farrelly C, Tissue-resident Eomeshi T-betlo CD56bright NK cells with reduced proinflammatory potential are enriched in the adult human liver, European Journal of Immunology, 46, (9), 2016, p2111 - 2120 Journal Article, 2016 DOI URL

Robinson M.W, Harmon C, O'Farrelly C, Liver immunology and its role in inflammation and homeostasis, Cellular and Molecular Immunology, 13, (3), 2016, p267 - 276 Journal Article, 2016 DOI URL TARA - Full Text

Foley C, Chapwanya A, Callanan J.J, Whiston R, Miranda-CasoLuengo R, Lu J, Meijer W.G, Lynn D.J, O'Farrelly C, Meade K.G, Erratum to: 'Integrated analysis of the local and systemic changes preceding the development of post-partum cytological endometritis'[BMC Genomics. 2015;16:811.], 2015, - Miscellaneous, 2015 DOI URL

Foley C, Chapwanya A, Callanan JJ, Whiston R, Miranda-CasoLuengo R, Lu J, Meijer WG, Lynn DJ, O' Farrelly C, Meade KG, Integrated analysis of the local and systemic changes preceding the development of post-partum cytological endometritis., BMC genomics, 16, 2015, p811 Journal Article, 2015 DOI TARA - Full Text

Murphy, T.M. O'Donovan, A. Mullins, N. O'Farrelly, C. McCann, A. Malone, K., Anxiety is associated with higher levels of global DNA methylation and altered expression of epigenetic and interleukin-6 genes, Psychiatric Genetics, 25, (2), 2015, p71 - 78 Journal Article, 2015 URL DOI

Thiruchelvam U, Wingfield M, O'Farrelly C, Natural Killer Cells: Key Players in Endometriosis, American Journal of Reproductive Immunology, 74, (4), 2015, 291-301 Journal Article, 2015 URL

Collins, A.S. Ahmed, S. Napoletano, S. Schroeder, M. Johnston, J.A. Hegarty, J.E. O'Farrelly, C. Stevenson, N.J., Hepatitis C virus (HCV)-induced suppressor of cytokine signaling (SOCS) 3 regulates proinflammatory TNF-- responses, Journal of Leukocyte Biology, 96, (2), 2014, p255 - 263 Journal Article, 2014 URL DOI

Kelly, A, Fahey, R, Fletcher, JM, Keogh, C, Carroll, AG, Siddachari, R, Geoghegan, J, Hegarty, JE, Ryan, EJ, O'Farrelly, C, CD141(+) myeloid dendritic cells are enriched in healthy human liver, JOURNAL OF HEPATOLOGY, 60, (1), 2014, p135-142 Journal Article, 2014 DOI

Whelehan, CJ, Barry-Reidy, A, Meade, KG, Eckersall, PD, Chapwanya, A, Narciandi, F, Lloyd, AT, O'Farrelly, C, Characterisation and expression profile of the bovine cathelicidin gene repertoire in mammary tissue, BMC GENOMICS, 15, 2014, p128- Journal Article, 2014 DOI TARA - Full Text

Tynan GA, Hearnden CH, Oleszycka E, Lyons CL, Coutts G, O'Connell J, Corrigan MA, Lynch L, Campbell M, Callanan JJ, Mok KH, Geoghegan J, O'Farrelly C, Allan SM, Roche HM, O'Shea DB, Lavelle EC, Endogenous oils derived from human adipocytes are potent adjuvants that promote IL-1 alpha-dependent inflammation., Diabetes, 63, (3), 2014, p2037-2050 Journal Article, 2014 DOI TARA - Full Text

Meade, K.G., Cormican, P., Narciandi, F., Lloyd, A., O'Farrelly, C., Bovine β-defensin gene family: Opportunities to improve animal health?, Physiological Genomics, 46, (1), 2014, p17-28 Journal Article, 2014 DOI TARA - Full Text

Collins AS, Ahmed S Napoletano S, Schroeder M, Johnston JA, Hegarty JE, O'Farrelly C and Stevenson NJ. , Hepatitis C virus (HCV) induced suppressor of cytokine signalling (SOCS) 3 regulates proinflammatory tumour necrosis factor (TNF)-α responses. , The Journal of Leukocyte Biology, 96, (2), 2014, p255-63 Journal Article, 2014 TARA - Full Text DOI

Tynan, GA, Hearnden, CH, Oleszycka, E, Lyons, CL, Coutts, G, O'Connell, J, Corrigan, MA, Lynch, L, Campbell, M, Callanan, JJ, Mok, KH, Geoghegan, J, O'Farrelly, C, Allan, SM, Roche, HM, O'Shea, DB, Lavelle, EC, Endogenous Oils Derived From Human Adipocytes Are Potent Adjuvants That Promote IL-1 alpha-Dependent Inflammation, Diabetes, 63, (6), 2014, p2037-2050 Journal Article, 2014 DOI TARA - Full Text

Kelly, Aoife Ryan, Elizabeth J. O'Farrelly, Cliona, Reply to: "Dendritic cell subset composition in the human liver is more complex than it seems", Journal of Hepatology, 60, (5), 2014, p1098-1099 Journal Article, 2014 TARA - Full Text

Bourke NM, O'Neill M, Sarwar S, Norris S, Stewart S, Hegarty JE, Stevenson NJ and O'Farrelly C., In vitro Blood Cell Responsiveness to IFN-alpha Predicts Clinical Response Independently of IL28B in Hepatitis C Virus Genotype 1 Infected Patients., Journal of Translational Medicine, 2014, p204- Journal Article, 2014 DOI TARA - Full Text

Morrison, M.H., Keane, C., Quinn, L.M., (...), Bergin, C., Gardiner, C.M., IFNL cytokines do not modulate human or murine NK cell functions, Human Immunology, 75, (9), 2014, 996-1000 Journal Article, 2014 TARA - Full Text DOI

Fitzmaurice K, Hurst J, Dring M, Rauch A, McLaren P.J, GÌnthard H.F, Gardiner C, Klenerman P, Courtney G, Crosbie O, Crowe J, Fanning L, Hegarty J, Kelleher D, Lawlor E, Lee J, McKiernan S, Murray F, Norris S, O'Farrelly C, Thornton L, Aubert V, Battegay M, Bernasconi E, Böni J, Bucher H.C, Burton-Jeangros C, Calmy A, Cavassini M, Egger M, Elzi L, Fehr J, Fellay J, Furrer H, Fux C.A, Gorgievski M, Haerry D, Hasse B, Hirsch H.H, Hösli I, Kahlert C, Kaiser L, Keiser O, Klimkait T, Kouyos R, Kovari H, Ledergerber B, Martinetti G, Martinez De Tejada B, Metzner K, MÌller N, Nadal D, Pantaleo G, Regenass S, Rickenbach M, Rudin C, Schöni-Affolter F, Schmid P, Schultze D, SchÌpbach J, Speck R, Tarr P, Telenti A, Trkola A, Vernazza P, Weber R, Yerly S, Additive effects of HLA alleles and innate immune genes determine viral outcome in HCV infection, Gut, 64, (5), 2014, p813 - 819 Journal Article, 2014 DOI URL

McLoughlin KE, Nalpas NC, Rue-Albrecht K, Browne JA, Magee DA, Killick KE, Park SD, Hokamp K, Meade KG, O'Farrelly C, Gormley E, Gordon SV, MacHugh DE, RNA-seq Transcriptional Profiling of Peripheral Blood Leukocytes from Cattle Infected with Mycobacterium bovis., Frontiers in immunology, 5, 2014, p396 Journal Article, 2014 DOI TARA - Full Text

Kelly, A., Fahey, R., Fletcher, J.M., Keogh, C., Carroll, A.G., Siddachari, R., Geoghegan, J., Hegarty, J.E., Ryan, E.J., O'Farrelly, C., CD141+ myeloid dendritic cells are enriched in healthy human liver, Journal of Hepatology, 60, (1), 2014, p135-142 Journal Article, 2014 DOI

Lawless, N. Vegh, P. O'Farrelly, C. Lynn, D.J., The role of microRNAs in bovine infection and immunity, Front. Immunol., 5, (NOV), 2014, p611- Journal Article, 2014 DOI TARA - Full Text URL

Lawless, N., Reinhardt, T.A., Bryan, K., (...), Lippolis, J., Lynn, D.J., Microrna regulation of bovine monocyte inflammatory and metabolic networks in an in Vivo infection model, G3: Genes, Genomes, Genetics, 4, (6), 2014, p957-971 Journal Article, 2014 DOI TARA - Full Text

Collins AS, McCoy CE, Lloyd AT, O'Farrelly C and Stevenson NJ. , miR-19a: an effective regulator of SOCS3 and enhancer of JAK-STAT signalling. , PLoS ONE, 8, (7), 2013, pe69090 Journal Article, 2013 TARA - Full Text DOI

Collins AS, McCoy CE, Lloyd AT, O'Farrelly C, Stevenson NJ, miR-19a: An Effective Regulator of SOCS3 and Enhancer of JAK-STAT Signalling., PloS one, 8, (7), 2013, pe69090 Journal Article, 2013 DOI TARA - Full Text

Doherty, R., O'Farrelly, C., Meade, K.G., Epigenetic regulation of the innate immune response to LPS in bovine peripheral blood mononuclear cells (PBMC), Veterinary Immunology and Immunopathology, 154, (3-4), 2013, p102-110 Journal Article, 2013 DOI

O'Donovan, A., Rush, G., Hoatam, G., Hughes, B.M., McCrohan, A., Kelleher, C., O'Farrelly, C., Malone, K.M., Suicidal ideation is associated with elevated inflammation in patients with major depressive disorder, Depression and Anxiety , 30, (4), 2013, p307-314 Journal Article, 2013 DOI

Killick, K.E., Ní Cheallaigh, C., O'Farrelly, C., (...), Machugh, D.E., Harris, J., Receptor-mediated recognition of mycobacterial pathogens, Cellular Microbiology, 15, (9), 2013, p1484-1495 Journal Article, 2013 DOI

Chapwanya, A., Meade, K.G., Doherty, M.L., Callanan, J.J., O'Farrelly, C., Endometrial epithelial cells are potent producers of tracheal antimicrobial peptide and serum amyloid A3 gene expression in response to E. coli stimulation, Veterinary Immunology and Immunopathology , 151, (1-2), 2013, p157-162 Journal Article, 2013 DOI

Lawless N, Foroushani AB, McCabe MS, O'Farrelly C, Lynn DJ, Next Generation Sequencing Reveals the Expression of a Unique miRNA Profile in Response to a Gram-Positive Bacterial Infection., PloS one, 8, (3), 2013, pe57543 Journal Article, 2013 DOI TARA - Full Text

Stevenson NJ, Bourke NM, Ryan EJ, Binder M, Fanning L, Johnston JA, Hegarty JE, Long A, O'Farrelly C, Hepatitis C Virus targets the Interferon-" JAK/STAT pathway by promoting proteasomal degradation in immune cells and hepatocytes., FEBS letters, 587, (10), 2013, p1571-1578 Journal Article, 2013 DOI TARA - Full Text

Narciandi F, Lloyd A, Meade KG, O'Farrelly C, A novel subclass of bovine ?-defensins links reproduction and immunology., Reproduction, fertility, and development, 2013 Journal Article, 2013

Connell, S, Meade, KG, Allan, B, Lloyd, AT, Downing, T, O'Farrelly, C, Bradley, DG, Genome-Wide Association Analysis of Avian Resistance to Campylobacter jejuni Colonization Identifies Risk Locus Spanning the CDH13 Gene, G3-GENES GENOMES GENETICS, 3, (5), 2013, p881-890 Journal Article, 2013 TARA - Full Text DOI

Lawless, N., Foroushani, A.B.K., McCabe, M.S., O'Farrelly, C., Lynn, D.J., Next Generation Sequencing Reveals the Expression of a Unique miRNA Profile in Response to a Gram-Positive Bacterial Infection, PLoS ONE, 8, (3), 2013, part. no. e57543 Journal Article, 2013 DOI TARA - Full Text

Klintmalm, G., O'Farrelly, C., Taking the rap: Multiple effects of blocking mammalian target of rapamycin, Hepatology, 57, (1), 2013, p1-3 Journal Article, 2013 DOI

McMenamin M, Lysakova-Devine T, Wingfield M, O'Herlihy C, O'Farrelly C, Endometrial aspiration biopsy: a non-invasive method of obtaining functional lymphoid progenitor cells and mature natural killer cells., Reproductive biomedicine online, 25, (3), 2012, p322-328 Journal Article, 2012 DOI

Meade KG, O'Gorman GM, Narciandi F, Machugh DE, O'Farrelly C, Functional characterisation of bovine interleukin 8 promoter haplotypes in vitro., Molecular immunology, 50, (1-2), 2012, p108-116 Journal Article, 2012 DOI

Chapwanya A, Meade KG, Foley C, Narciandi F, Evans AC, Doherty ML, Callanan JJ, O'Farrelly C, The postpartum endometrial inflammatory response: a normal physiological event with potential implications for bovine fertility., Reproduction, fertility, and development, 24, (8), 2012, p1028-1039 Journal Article, 2012 DOI

Szereday L, Miko E, Meggyes M, Barakonyi A, Farkas B, Varnagy A, Bodis J, Lynch L, O'Farrelly C, Szekeres-Bartho J, Commitment of decidual haematopoietic progenitor cells in first trimester pregnancy., American journal of reproductive immunology (New York, N.Y. : 1989), 67, (1), 2012, p9-16 Journal Article, 2012 DOI

Connell S, Meade KG, Allan B, Lloyd AT, Kenny E, Cormican P, Morris DW, Bradley DG, O'Farrelly C, Avian resistance to Campylobacter jejuni colonization is associated with an intestinal immunogene expression signature identified by mRNA sequencing., PloS one, 7, (8), 2012, pe40409 Journal Article, 2012 DOI TARA - Full Text

Sarwar S, Ryan EJ, Iqbal M, McCormick PA, O'Farrelly C, Hegarty J, Rapid, early and sustained virological responses in a cohort of Irish patients treated with pegylated interferon and ribavirin for chronic hepatitis C virus infection., Irish journal of medical science, 181, (1), 2012, p53-58 Journal Article, 2012 DOI

Lynch L, Nowak M, Varghese B, Clark J, Hogan AE, Toxavidis V, Balk SP, O'Shea D, O'Farrelly C, Exley MA, Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production., Immunity, 37, (3), 2012, p574-87 Journal Article, 2012 TARA - Full Text DOI

Foley C, Chapwanya A, Creevey CJ, Narciandi F, Morris D, Kenny EM, Cormican P, Callanan JJ, O'Farrelly C, Meade KG, Global endometrial transcriptomic profiling: transient immune activation precedes tissue proliferation and repair in healthy beef cows., BMC genomics, 13, (1), 2012, p489 Journal Article, 2012 DOI TARA - Full Text

Nanda KS, Brady JJ, Murray BF, Sullivan O, Fearon U, McKenna MJ, Hegarty JE, O'Farrelly C, Ryan EJ, Elevated circulating osteoprotegerin and reduced matrix-metalloprotease-9 in post-menopausal women with chronic Hepatitis C virus infection., Cytokine, 60, (2), 2012, p328-33 Journal Article, 2012 DOI

Ryan, E.J., Stevenson, N.J., Hegarty, J.E., O'Farrelly, C., Chronic hepatitis C infection blocks the ability of dendritic cells to secrete IFN-α and stimulate T-cell proliferation, Journal of Viral Hepatitis , 18, (12), 2011, p840-851 Journal Article, 2011 TARA - Full Text DOI

Kate E Killick, John A Browne, Stephen DE Park, David A Magee, Irene Martin, Kieran G Meade, Stephen V Gordon, Eamonn Gormley, Cliona O'Farrelly, Karsten Hokamp and David E MacHugh, Genome-wide transcriptional profiling of peripheral blood leukocytes from cattle infected with Mycobacterium bovis reveals suppression of host immune genes, BMC Genomics , 12, (611), 2011 Journal Article, 2011 TARA - Full Text

Cormac J. Whelehan, Kieran G. Meade, P. David Eckersall, Fiona J. Young, Cliona O'Farrelly, EXPERIMENTAL STAPHYLOCOCCUS AUREUS INFECTION OF THE MAMMARY GLAND INDUCES REGION-SPECIFIC CHANGES IN INNATE IMMUNE GENE EXPRESSION, Veterinary Immunology and Immunopathology, 140, (3-4), 2011, p181-189 Journal Article, 2011 TARA - Full Text

Ronan G. Shaughnessy, Kieran G. Meade, Beatrice A. McGivney, Brenda Allan, Cliona O' Farrelly, Global gene expression analysis of chicken caecal response to Campylobacter jejuni, Veterinary Immunology and Immunopathology, 142, (1-2), 2011, p64-71 Journal Article, 2011 TARA - Full Text

Ryan, E.J., O'Farrelly, C., The affect of chronic hepatitis C infection on dendritic cell function: A summary of the experimental evidence, Journal of Viral Hepatitis, 18, (9), 2011, p601-607 Journal Article, 2011 DOI

Petrovic D., Stamataki Z., Dempsey E., Golden-Mason L., Freeley M., Doherty D., Prichard D., Keogh C., Conroy J., Mitchell S., Volkov Y., McKeating J.A., O'Farrelly C., Kelleher D., Long A., Hepatitis C virus targets the Tcell secretory machinery as a mechanism of immune evasion, Hepatology, 53, (6), 2011, p1846 - 1853 Journal Article, 2011 URL DOI

Kevin P. Kennelly, Deborah M. Wallace, Toby M. Holmes, Deborah J. Hankey, Timothy S. Grant, Cliona O'Farrelly, David J. Keegan , Preparation of Pre-Confluent Retinal Cells Increases Graft Viability In Vitro and In Vivo: A Mouse Model, PLoS One, 6, (6, e21365), 2011 Journal Article, 2011 TARA - Full Text

Narciandi F, Lloyd AT, Chapwanya A, O' Farrelly C, Meade KG, Reproductive tissue-specific expression profiling and genetic variation across a 19 gene bovine ß-defensin cluster., Immunogenetics, 63, (10), 2011, p641-651 Journal Article, 2011 DOI

Foley, C., O'Farrelly, C., Meade, K.G, Technical note: Comparative analyses of the quality and yield of genomic DNA from invasive and noninvasive, automated and manual extraction methods, Journal of Dairy Science, 94, (6), 2011, p3159-3165ds Journal Article, 2011 DOI

Hogan AE, O'Reilly V, Dunne MR, Dere RT, Zeng SG, O'Brien C, Amu S, Fallon PG, Exley MA, O'Farrelly C, Zhu X, Doherty DG, Activation of human invariant natural killer T cells with a thioglycoside analogue of á-galactosylceramide, Clinical Immunology, 140, (2), 2011, p196-207 Journal Article, 2011 TARA - Full Text DOI

Tobin, A.M., Lynch, L., Kirby, B., O'Farrelly, C., Natural killer cells in psoriasis, Journal of Innate Immunity , 3, (4), 2011, 403-410 Journal Article, 2011 DOI

Dring MM, Morrison MH, McSharry BP, Guinan KJ, Hagan R, O'Farrelly C, Gardiner CM, Innate immune genes synergize to predict increased risk of chronic disease in hepatitis C virus infection., PNAS, 108, (14), 2011, p5736-41 Journal Article, 2011 DOI TARA - Full Text

Ceara E. Walsh, Elizabeth J. Ryan, Cliona O'Farrelly, Lucy Golden-Mason, Oliver FitzGerald, Douglas J. Veale, Barry Bresnihan, Ursula Fearon, Differential Expression of NK Receptors CD94 and NKG2A by T Cells in Rheumatoid Arthritis Patients in Remission Compared to Active Disease, PLoS One, 6, (11, e27182), 2011 Journal Article, 2011 TARA - Full Text

Stevenson NJ, Murphy AG, Bourke NB, Keogh CA, Hegarty JE, O'Farrelly C, Ribavirin Enhances IFN-α Signalling and MxA Expression: A Novel Immune Modulation Mechanism during Treatment of HCV, PLoS One, 6, (11), 2011, pe27866 Journal Article, 2011 TARA - Full Text

O'Shea, D., Cawood, T.J., O'Farrelly, C., Lynch, L., Natural killer cells in obesity: impaired function and increased susceptibility to the effects of cigarette smoke., PloS one, 5, (1), 2010, e8660 Journal Article, 2010 DOI TARA - Full Text

O'Brien M, Lonergan R, Costelloe L, O'Rourke K, Fletcher JM, Kinsella K, Sweeney C, Antonelli G, Mills KH, O'Farrelly C, Hutchinson M, Tubridy N. , OAS1: a multiple sclerosis susceptibility gene that influences disease severity., Neurology, 75, (5), 2010, p411 - 418 Journal Article, 2010 DOI

Stevenson NJ, McFarlane C, Ong ST, Nahlik K, Kelvin A, Addley MR, Long A, Greaves DR, O'Farrelly C and Johnston JA, Suppressor of cytokine signalling (SOCS) 1 and 3 enhance cell adhesion and inhibit migration towards the chemokine eotaxin/CCL11, FEBS Letters, 584, (21), 2010, p4469-4474 Journal Article, 2010 TARA - Full Text

Downing, T., O'Farrelly, C., Bhuiyan, A.K., Silva, P., Naqvi, A.N., Sanfo, R., Sow, R.-S., (...), Bradley, D.G.., Variation in chicken populations may affect the enzymatic activity of lysozyme, Animal Genetics, 41, (2), 2010, p213-217 Journal Article, 2010 DOI

Tajuddin, T., Ryan, E.J., Norris, S., Hegarty, J.E., O'Farrelly, C., Interferon-α suppressed granulocyte colony stimulating factor production is reversed by CL097, a TLR7/8 agonist, Journal of Gastroenterology and Hepatology, 25, (12), 2010, p1883-1890 Journal Article, 2010 DOI

O'Donovan, A., Hughes, B.M., Slavich, G.M., Lynch, L., Cronin, M.-T., O'Farrelly, C., Malone, K.M, Clinical anxiety, cortisol and interleukin-6: Evidence for specificity in emotion-biology relationships, Brain, Behavior, and Immunity, 24, (7), 2010, p1074-1077 Journal Article, 2010 DOI TARA - Full Text

Downing T, Lloyd AT, O'Farrelly C, Bradley DG, The differential evolutionary dynamics of avian cytokine and TLR gene classes., Journal of immunology (Baltimore, Md. : 1950), 184, (12), 2010, p6993-7000 Journal Article, 2010 DOI

O'Connell, J., Lynch, L., Cawood, T.J., Kwasnik, A., Nolan, N., Geoghegan, J., McCormick, A., (...), O'Shea, D., The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity, PLoS ONE , 5, (4), 2010, part. no. e9997 Journal Article, 2010 TARA - Full Text DOI

Elizabeth J. Ryan, Megan Dring, Cliona M. Ryan, Carol McNulty, Nigel J. Stevenson, Matthew W. Lawless, John Crowe, Niamh Nolan, John E. Hegarty and Cliona O'Farrelly, A variant in the CD209 promoter is associated with the severity of liver disease in chronic Hepatitis C virus infection, Human Immunology, 71, (8), 2010, p829-832 Journal Article, 2010 TARA - Full Text

Smith, KJ, Norris, S, O'Dwyer, AM & O'Mara, SM. , Risk factors for the development of depression in patients with Hepatitis C taking Interferon-alpha., Neuropsychiatric Disease and Treatment, 2010, p1-18 Journal Article, 2010 TARA - Full Text

Chapwanya, A., Meade, K.G., Narciandi, F., Stanley, P., Mee, J.F., Doherty, M.L., Callanan, J.J., O'Farrelly, C., Endometrial biopsy: a valuable clinical and research tool in bovine reproduction, Theriogenology, 73, (7), 2010, p988-994 Journal Article, 2010 DOI

Nanda, K.S., Ryan, E.J., Murray, B.F., Brady, J.J., McKenna, M.J., Nolan, N., O'Farrelly, C., Hegarty, J.E., Effect of Chronic Hepatitis C Virus Infection on Bone Disease in Postmenopausal Women, Clinical Gastroenterology and Hepatology, 7, (8), 2009, p894-899 Journal Article, 2009 DOI

Cormican P, Lloyd AT, Downing T, Connell SJ, Bradley D, O'Farrelly C, The avian Toll-Like receptor pathway--subtle differences amidst general conformity., Developmental and comparative immunology, 33, (9), 2009, p967-73 Journal Article, 2009 DOI

O'Neill, L.A.J., O'Farrelly, C., The immune system as an invisible, silent Grand Fugue, Nature Immunology, 10, (10), 2009, p1043-1045 Journal Article, 2009 DOI

Meade, K.G., Narciandi, F., Cahalane, S., Reiman, C., Allan, B., O'Farrelly, C., Comparative in vivo infection models yield insights on early host immune response to Campylobacter in chickens, Immunogenetics, 61, (2), 2009, p101-110 Journal Article, 2009 DOI

Mcgrath, E., Ryan, E.J., Lynch, L., Golden-Mason, L., Mooney, E., Eogan, M., O'herlihy, C., O'Farrelly, C., Changes in endometrial natural killer cell expression of CD94, CD158a and CD158b are associated with infertility, American Journal of Reproductive Immunology, 61, (4), 2009, p265-276 Journal Article, 2009 DOI

Chapwanya, A., Meade, K.G., Doherty, M.L., Callanan, John.J., Mee, J.F., O'Farrelly, C, Histopathological and molecular evaluation of Holstein-Friesian cows postpartum: Toward an improved understanding of uterine innate immunity, Theriogenology, 71, (9), 2009, p1396-1407 Journal Article, 2009 DOI

Fletcher JM, Lonergan R, Costelloe L, Kinsella K, Moran B, O'Farrelly C, Tubridy N, Mills KH, CD39+Foxp3+ regulatory T Cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis., Journal of Immunology , 183, (11), 2009, p7602-7610 Journal Article, 2009 TARA - Full Text DOI

Downing, T., Lynn, D.J., Connell, S., Lloyd, A.T., Bhuiyan, A.K.F.H., Silva, P., Naqvi, A.N., (...), Bradley, D.G. , Erratum: Contrasting evolution of diversity at two disease-associated chicken genes (Immunogenetics DOI: 10.1007/s00251-009-0359-x), 2009, - 421-422 Miscellaneous, 2009

Lynch L, O'Shea D, Winter DC, Geoghegan J, Doherty DG, O'Farrelly C, Invariant NKT cells and CD1d+ cells amass in human omentum and are depleted in patients with cancer and obesity., European Journal of Immunology, 39, (7), 2009, p1893-1901 Journal Article, 2009 DOI

Downing, T, Lynn, DJ, Connell, S, Lloyd, AT, Bhuiyan, AF, Silva, P, Naqvi, AN, Sanfo, R, Sow, RS, Podisi, B, O'Farrelly, C, Hanotte, O, Bradley, DG, Contrasting evolution of diversity at two disease-associated chicken genes., Immunogenetics, 61, (1), 2009, p303 - 314 Journal Article, 2009 DOI

Lynch, L.A., O'Connell, J.M., Kwasnik, A.K., Cawood, T.J., O'Farrelly, C., O'Shea, D.B., Are natural killer cells protecting the metabolically healthy obese patient?, Obesity, 17, (3), 2009, p601-605 Journal Article, 2009 DOI

Nemeth, E., Baird, A.W., O'Farrelly, C., Microanatomy of the liver immune system, Seminars in Immunopathology, 31, (3), 2009, p333-343 Journal Article, 2009 DOI

Ronan G. Shaughnessy, Kieran G. Meade, Sarah Cahalane, Brenda Allan, Carla Reiman, John J. Callanan and Cliona O' Farrelly, Innate immune gene expression differentiates the early avian intestinal response between Salmonella and Campylobacter, Veterinary Immunology and Immunopathology, 132, (2-4), 2009, p191-198 Journal Article, 2009 TARA - Full Text DOI

Downing T, Lynn DJ, Connell S, Lloyd AT, Bhuiyan AK, Silva P, Naqvi AN, Sanfo R, Sow RS, Podisi B, Hanotte O, O'Farrelly C, Bradley DG, Evidence of balanced diversity at the chicken interleukin 4 receptor alpha chain locus., BMC Evolutionary Biology, 9, 2009, part. no. 136 Journal Article, 2009 TARA - Full Text DOI URL

Downing T, Cormican P, O'Farrelly C, Bradley DG, Lloyd AT, Evidence of the adaptive evolution of immune genes in chicken, BMC Research Notes, 2, (254), 2009, part. no. 254 Journal Article, 2009 TARA - Full Text DOI URL

MacHugh, D.E., Gormley, E., Park, S.D.E., Browne, J.A., Taraktsoglou, M., O'Farrelly, C., Meade, K.G., Gene expression profiling of the host response to mycobacterium bovis infection in cattle, Transboundary and Emerging Diseases , 56, (6-7), 2009, p204-214 Journal Article, 2009 DOI

Kieran G. Meade, Rowan Higgs, Andrew T. Lloyd, Seamus Giles and Cliona O'Farrelly, Differential antimicrobial peptide gene expression patterns during early chicken embryological development , Developmental & Comparative Immunology, 33, (4), 2009, p516-524 Journal Article, 2009 TARA - Full Text

Meade, K.G., O'Gorman, G.M., Hill, E.W., Narciandi, F., Agaba, M., Kemp, S.J., O'Farrelly, C., MacHugh, D.E., Divergent antimicrobial peptide (AMP) and acute phase protein (APP) responses to Trypanosoma congolense infection in trypanotolerant and trypanosusceptible cattle, Molecular Immunology, 47, (2-3), 2009, p196-204 Journal Article, 2009 DOI

Rosen, HR, Doherty, DG, Madrigal-Estebas, L, O'Farrelly, C, Golden-Mason, L, Pretransplantation CD56(+) innate lymphocyte populations associated with severity of hepatitis C virus recurrence., Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 14, (1), 2008, p31 - 40 Journal Article, 2008 DOI URL

Golden-Mason, L, Madrigal-Estebas, L, McGrath, E, Conroy, MJ, Ryan, EJ, Hegarty, JE, O'Farrelly, C, Doherty, DG, Altered natural killer cell subset distributions in resolved and persistent hepatitis C virus infection following single source exposure., Gut, 57, (8), 2008, p1121-8 Journal Article, 2008 DOI URL

Meade, KG, Gormley, E, O'Farrelly, C, Park, SD, Costello, E, Keane, J, Zhao, Y, MacHugh, DE, Antigen stimulation of peripheral blood mononuclear cells from Mycobacterium bovis infected cattle yields evidence for a novel gene expression program., BMC genomics, 9, (447), 2008 Journal Article, 2008 URL DOI

Davies D, Meade KG, Herath S, Eckersall PD, Gonzalez D, White JO, Conlan RS, O'Farrelly C, Sheldon IM, Toll-like receptor and antimicrobial peptide expression in the bovine endometrium., Reproductive biology and endocrinology : RB&E, 6, 2008, p53 Journal Article, 2008 TARA - Full Text DOI

Meade, KG, Cahalane, S, Narciandi, F, Cormican, P, Lloyd, AT, O'Farrelly, C, Directed alteration of a novel bovine beta-defensin to improve antimicrobial efficacy against methicillin-resistant Staphylococcus aureus (MRSA)., International journal of antimicrobial agents, 32, (5), 2008, p392-397 Journal Article, 2008 URL DOI

Meade KG, Gormley E, O'Farrelly C, Park SD, Costello E, Keane J, Zhao Y, Machugh DE., Antigen stimulation of peripheral blood mononuclear cells from Mycobacterium bovis infected cattle yields evidence for a novel gene expression program., BMC Genomics, 29, (9), 2008, p447- Journal Article, 2008 TARA - Full Text DOI

Cormican, P, Meade, KG, Cahalane, S, Narciandi, F, Chapwanya, A, Lloyd, AT, O'Farrelly, C, Evolution, expression and effectiveness in a cluster of novel bovine beta-defensins., Immunogenetics, 60, (3-4), 2008, p147-156 Journal Article, 2008 DOI URL

Kenna, T, O'Brien, M, Hogan, AE, Exley, MA, Porcelli, SA, Hegarty, JE, O'Farrelly, C, Doherty, DG, CD1 expression and CD1-restricted T cell activity in normal and tumour-bearing human liver., Cancer immunology, immunotherapy : CII, 56, (4), 2007, p563-72 Journal Article, 2007 DOI URL

Golden-Mason, L, Castelblanco, N, O'Farrelly, C, Rosen, HR, Phenotypic and functional changes of cytotoxic CD56pos natural T cells determine outcome of acute hepatitis C virus infection., Journal of virology, 81, (17), 2007, p9292-9298 Journal Article, 2007 TARA - Full Text DOI URL

Zaman, MB, Leonard, MO, Ryan, EJ, Nolan, NP, Hoti, E, Maguire, D, Mulcahy, H, Traynor, O, Taylor, CT, Hegarty, JE, Geoghegan, JG, O'Farrelly, C, Lower expression of Nrf2 mRNA in older donor livers: a possible contributor to increased ischemia-reperfusion injury?, Transplantation, 84, (10), 2007, p1272-8 Journal Article, 2007 DOI URL

Lynch, L, Golden-Mason, L, Eogan, M, O';Herlihy, C, O'Farrelly, C, Cells with haematopoietic stem cell phenotype in adult human endometrium: relevance to infertility?, Human reproduction (Oxford, England), 22, (4), 2007, p919-26 Journal Article, 2007 DOI TARA - Full Text URL

Meade, KG, Gormley, E, Doyle, MB, Fitzsimons, T, O'Farrelly, C, Costello, E, Keane, J, Zhao, Y, MacHugh, DE, Innate gene repression associated with Mycobacterium bovis infection in cattle: toward a gene signature of disease., BMC genomics, 8, 2007, p400 Journal Article, 2007 URL DOI TARA - Full Text

Leonard, MO, Kieran, NE, Howell, K, Burne, MJ, Varadarajan, R, Dhakshinamoorthy, S, Porter, AG, O'Farrelly, C, Rabb, H, Taylor, CT, Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury., The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2006 Journal Article, 2006 URL DOI

Cawood, TJ, Moriarty, P, O'Farrelly, C, O'Shea, D, The effects of tumour necrosis factor-alpha and interleukin1 on an in vitro model of thyroid-associated ophthalmopathy; contrasting effects on adipogenesis., European journal of endocrinology / European Federation of Endocrine Societies, 155, (3), 2006, p395-403 Journal Article, 2006 TARA - Full Text DOI URL

Canny, G, Drudy, D, Macmathuna, P, O'Farrelly, C, Baird, AW, Toxigenic C. difficile induced inflammatory marker expression by human intestinal epithelial cells is asymmetrical., Life Sciences, 78, (9), 2006, p920-5 Journal Article, 2006 DOI URL

Kelly, AM, Golden-Mason, L, Traynor, O, Geoghegan, J, McEntee, G, Hegarty, JE, O'Farrelly, C, Changes in hepatic immunoregulatory cytokines in patients with metastatic colorectal carcinoma: implications for hepatic anti-tumour immunity., Cytokine, 35, (3-4), 2006, p171-9 Journal Article, 2006 URL DOI

Higgs, R, Cormican, P, Cahalane, S, Allan, B, Lloyd, AT, Meade, K, James, T, Lynn, DJ, Babiuk, LA, O'farrelly, C, Induction of a novel chicken Toll-like receptor following Salmonella enterica serovar Typhimurium infection., Infection and immunity, 74, (3), 2006, p1692- Journal Article, 2006 DOI TARA - Full Text

Volkov, Y, Long, A, Freeley, M, Golden-Mason, L, O'Farrelly, C, Murphy, A, Kelleher, D, The hepatitis C envelope 2 protein inhibits LFA-1-transduced protein kinase C signaling for T-lymphocyte migration., Gastroenterology, 130, (2), 2006, p482-92 Journal Article, 2006 URL DOI

Lynch, L, O'Donoghue, D, Dean, J, O'Sullivan, J, O'Farrelly, C, Golden-Mason, L, Detection and characterization of hemopoietic stem cells in the adult human small intestine., Journal of immunology (Baltimore, Md. : 1950), 176, (9), 2006, p5199-204 Journal Article, 2006 URL

Dean, J, McCarthy, D, Golden-Mason, L, O'Farrelly, C, Trephine biopsies are enriched for activated T/NK cells and cytotoxic T cells., Immunology letters, 99, (1), 2005, p94-102 Journal Article, 2005 DOI URL

Higgs, R, Lynn, DJ, Gaines, S, McMahon, J, Tierney, J, James, T, Lloyd, AT, Mulcahy, G, O'Farrelly, C, The synthetic form of a novel chicken beta-defensin identified in silico is predominantly active against intestinal pathogens., Immunogenetics, 57, (1-2), 2005, p90-8 Journal Article, 2005 DOI URL

Dean, J, McCarthy, D, Lawler, M, Doherty, DG, O'Farrelly, C, Golden-Mason, L, Characterization of NKR+ T-cell subsets in human bone marrow: implications for immunosurveillance of neoplasia., Clinical immunology (Orlando, Fla.), 114, (1), 2005, p42-51 Journal Article, 2005 DOI URL

Lynn, DJ, Lloyd, AT, Fares, MA, O'Farrelly, C, Evidence of positively selected sites in mammalian alpha-defensins., Molecular biology and evolution, 21, (5), 2004, p819-827 Journal Article, 2004 TARA - Full Text URL DOI

O'Keeffe, J, Doherty, DG, Kenna, T, Sheahan, K, O'Donoghue, DP, Hyland, JM, O'Farrelly, C, Diverse populations of T cells with NK cell receptors accumulate in the human intestine in health and in colorectal cancer., European journal of immunology, 34, (8), 2004, p2110 - 2119 Journal Article, 2004 DOI URL

Kelly, AM, Golden-Mason, L, McEntee, G, Traynor, O, Doherty, DG, Hegarty, JE, O'Farrelly, C, Interleukin 12 (IL-12) is increased in tumour bearing human liver and expands CD8(+) and CD56(+) T cells in vitro but not in vivo., Cytokine, 25, (6), 2004, p273-282 Journal Article, 2004 DOI URL

Golden-Mason, L, Douek, DC, Koup, RA, Kelly, J, Hegarty, JE, O'Farrelly, C, Adult human liver contains CD8pos T cells with naive phenotype, but is not a site for conventional alpha beta T cell development., Journal of immunology (Baltimore, Md. : 1950), 172, (10), 2004, p5980-5 Journal Article, 2004 URL

Varadarajan, R, Golden-Mason, L, Young, L, McLoughlin, P, Nolan, N, McEntee, G, Traynor, O, Geoghegan, J, Hegarty, JE, O'Farrelly, C, Nitric oxide in early ischaemia reperfusion injury during human orthotopic liver transplantation., Transplantation, 78, (2), 2004, p250-6 Journal Article, 2004 URL

Lynn, DJ, Higgs, R, Gaines, S, Tierney, J, James, T, Lloyd, AT, Fares, MA, Mulcahy, G, O'Farrelly, C, Bioinformatic discovery and initial characterisation of nine novel antimicrobial peptide genes in the chicken., Immunogenetics, 56, (3), 2004, p170-177 Journal Article, 2004 URL DOI

Golden-Mason, L, Kelly, AM, Doherty, DG, Traynor, O, McEntee, G, Kelly, J, Hegarty, JE, O'Farrelly, C, Hepatic interleuklin 15 (IL-15) expression: implications for local NK/NKT cell homeostasis and development., Clinical and experimental immunology, 138, (1), 2004, p94-101 Journal Article, 2004 URL DOI TARA - Full Text

Carton, J, Byrne, B, Madrigal-Estebas, L, O'Donoghue, DP, O'Farrelly, C, CD4+CD8+ human small intestinal T cells are decreased in coeliac patients, with CD8 expression downregulated on intra-epithelial T cells in the active disease., European journal of gastroenterology & hepatology, 16, (10), 2004, p961-8 Journal Article, 2004 URL

O'Farrelly, C, Immunoregulation in the liver and its extrahepatic relevance., Journal of pediatric gastroenterology and nutrition, 39 Suppl 3, 2004, pS727-S728 Journal Article, 2004 URL

Kenna, T, Golden-Mason, L, Norris, S, Hegarty, JE, O'Farrelly, C, Doherty, DG, Distinct subpopulations of gamma delta T cells are present in normal and tumor-bearing human liver., Clinical immunology (Orlando, Fla.), 113, (1), 2004, p56-63 Journal Article, 2004 DOI URL

Curry, MP, Golden-Mason, L, Doherty, DG, Deignan, T, Norris, S, Duffy, M, Nolan, N, Hall, W, Hegarty, JE, O'Farrelly, C, Expansion of innate CD5pos B cells expressing high levels of CD81 in hepatitis C virus infected liver., Journal of Hepatology, 38, (5), 2003, p642-50 Journal Article, 2003 URL DOI

Gaines, S, James, TC, Folan, M, Baird, AW, O'Farrelly, C, A novel spectrofluorometric microassay for Streptococcus mutans adherence to hydroxylapatite., Journal of microbiological methods, 54, (3), 2003, p315-23 Journal Article, 2003 DOI URL

Norris, S, Doherty, DG, Curry, M, McEntee, G, Traynor, O, Hegarty, JE, O'Farrelly, C, Selective reduction of natural killer cells and T cells expressing inhibitory receptors for MHC class I in the livers of patients with hepatic malignancy., Cancer immunology, immunotherapy : CII, 52, (1), 2003, p53-8 Journal Article, 2003 DOI URL

Lynn, DJ, Lloyd, AT, O'Farrelly, C, In silico identification of components of the Toll-like receptor (TLR) signaling pathway in clustered chicken expressed sequence tags (ESTs)., Veterinary immunology and immunopathology, 93, (3-4), 2003, p177-84 Journal Article, 2003 DOI URL

Kenna, T, Golden-Mason, L, Porcelli, SA, Koezuka, Y, Hegarty, JE, O'Farrelly, C, Doherty, DG, Mason, LG, NKT cells from normal and tumor-bearing human livers are phenotypically and functionally distinct from murine NKT cells., Journal of immunology (Baltimore, Md. : 1950), 171, (4), 2003, p1775-1779 Journal Article, 2003 URL

Smith, F, Golden-Mason, L, Deignan, T, Norris, S, Nolan, N, Traynor, O, McEntee, G, Hegarty, J, O'Farrelly, C, Localization of T and B lymphocytes in histologically normal adult human donor liver., Hepato-gastroenterology, 50, (53), 2003, p1311-5 Journal Article, 2003

Garland, M, Doherty, D, Golden-Mason, L, Fitzpatrick, P, Walsh, N, O'Farrelly, C, Stress-related hormonal suppression of natural killer activity does not show menstrual cycle variations: implications for timing of surgery for breast cancer., Anticancer research, 23, (3B), 2003, p2531 - 2535 Journal Article, 2003 Other

Hayden, PJ, O'Brien, M, Collins, B, O'Farrelly, C, Murphy, K, Inherited thrombotic tendency in a pedigree with antithrombin La Rochelle (N405K) and factor V Leiden., Clinical and laboratory haematology, 25, (3), 2003, p191 - 193 Journal Article, 2003 DOI URL

D. Brady, N. Lowe, S. Gaines L. Fenelon, J. McPartlin, C. O'Farrelly, Inhibition of S. mutans growth by hen egg derived fatty acids., J Food Sci, 68, (4), 2003, p1433-1437 Journal Article, 2003 DOI URL

Lynn, DJ, Lloyd, AT, O'Farrelly, C, Bioinformatics: implications for medical research and clinical practice., Clinical and investigative medicine. Médecine clinique et experimentale, 26, (2), 2003, p70-4 Journal Article, 2003

Madrigal-Estebas, L, Doherty, DG, O'Donoghue, DP, Feighery, C, O'Farrelly, C, Differential expression and upregulation of interleukin-1alpha, interleukin-1beta and interleukin-6 by freshly isolated human small intestinal epithelial cells., Mediators of inflammation, 11, (5), 2002, p313-319 Journal Article, 2002 URL DOI TARA - Full Text

Golden-Mason, L, O'Farrelly, C, Having it all? Stem cells, haematopoiesis and lymphopoiesis in adult human liver., Immunology and cell biology, 80, (1), 2002, p45-51 Journal Article, 2002 DOI URL

D. Brady, S. Gaines, L. Fenelon, J. Mc Partlin, C. O'Farrelly, A lipoprotein derived antimicrobial factor from hen egg yolk is active against Streptococcus species, J Food Sci , 67, (8), 2002, p3096-3103 Journal Article, 2002 URL DOI

Byrne, B, Madrigal-Estebas, L, McEvoy, A, Carton, J, Doherty, DG, Whelan, A, Feighery, C, O'Donoghue, DP, O'Farrelly, C, Human duodenal epithelial cells constitutively express molecular components of antigen presentation but not costimulatory molecules., Human immunology, 63, (11), 2002, p977-86 Journal Article, 2002 DOI URL

Deignan, T, Curry, MP, Doherty, DG, Golden-Mason, L, Volkov, Y, Norris, S, Nolan, N, Traynor, O, McEntee, G, Hegarty, JE, O'Farrelly, C, Decrease in hepatic CD56(+) T cells and V alpha 24(+) natural killer T cells in chronic hepatitis C viral infection., Journal of Hepatology, 37, (1), 2002, p101-8 Journal Article, 2002 URL DOI

Doherty, D.G., O'Farrelly, C., Dendritic cells: Regulators of hepatic immunity or tolerance?, Journal of Hepatology, 34, (1), 2001, p156-160 Journal Article, 2001 DOI

Dunne J, Lynch S, O'Farrelly C, Hegarty JE, Feighery C, Doherty DG., Selective expansion and partial activation of human NK cells and NK receptor-positive T cells by IL-2 and IL-15. , Journal of Immunology, 167, (6), 2001, p3129-3138 Journal Article, 2001 URL

Drudy, D, O'Donoghue, DP, Baird, A, Fenelon, L, O'Farrelly, C, Flow cytometric analysis of Clostridium difficile adherence to human intestinal epithelial cells., Journal of medical microbiology, 50, (6), 2001, p526-34 Journal Article, 2001 URL DOI

Golden-Mason, L, Kelly, AM, Traynor, O, McEntee, G, Kelly, J, Hegarty, JE, O'Farrelly, C, Expression of interleukin 7 (IL-7) mRNA and protein in the normal adult human liver: implications for extrathymic T cell development., Cytokine, 14, (3), 2001, p143-51 Journal Article, 2001 URL DOI

Dunne, J, Lynch, S, O'Farrelly, C, Todryk, S, Hegarty, JE, Feighery, C, Doherty, DG, Selective expansion and partial activation of human NK cells and NK receptor-positive T cells by IL-2 and IL-15., Journal of immunology (Baltimore, Md. : 1950), 167, (6), 2001, p3129-38 Journal Article, 2001 URL

T.Deignan, A. Alwan, L. Malone, J. Kelly, C. O'Farrelly. , Hen egg yolk prevents bacterial adherence: a novel function for a familiar food. , J Food Sci , 66, 2001, p158-161 Journal Article, 2001 URL DOI

Deignan, T, Alwan, A, Kelly, J, McNair, J, Warren, T, O'Farrelly, C, Serum haptoglobin: an objective indicator of experimentally-induced Salmonella infection in calves., Research in veterinary science, 69, (2), 2000, p153-8 Journal Article, 2000 DOI URL

Flynn, L, Byrne, B, Carton, J, Kelehan, P, O'Herlihy, C, O'Farrelly, C, Menstrual cycle dependent fluctuations in NK and T-lymphocyte subsets from non-pregnant human endometrium., American journal of reproductive immunology (New York, N.Y. : 1989), 43, (4), 2000, p209-17 Journal Article, 2000 URL DOI

Curry, MP, Golden-Mason, L, Nolan, N, Parfrey, NA, Hegarty, JE, O'Farrelly, C, Expansion of peripheral blood CD5+ B cells is associated with mild disease in chronic hepatitis C virus infection., Journal of Hepatology, 32, (1), 2000, p121-5 Journal Article, 2000 DOI URL

Doherty, D.G., O'Farrelly, C., Innate and adaptive lymphoid cells in the human liver , Immunological Reviews, 174, (1), 2000, p5-20 Review Article, 2000 DOI

O'Farrelly, C, Is villous atrophy always and only the result of gluten sensitive disease of the intestine?, European journal of Gastroenterology & Hepatology, 12, (6), 2000, p605-8 Journal Article, 2000

Golden-Mason, L, Curry, MP, Nolan, N, Traynor, O, McEntee, G, Kelly, J, Hegarty, JE, O'Farrelly, C, Differential expression of lymphoid and myeloid markers on differentiating hematopoietic stem cells in normal and tumor-bearing adult human liver., Hepatology (Baltimore, Md.), 31, (6), 2000, p1251-6 Journal Article, 2000 URL DOI

Curry, MP, Norris, S, Golden-Mason, L, Doherty, DG, Deignan, T, Collins, C, Traynor, O, McEntee, GP, Hegarty, JE, O'Farrelly, C, Isolation of lymphocytes from normal adult human liver suitable for phenotypic and functional characterization., Journal of Immunological Methods, 242, (1-2), 2000, p21-31 Journal Article, 2000 DOI

T. Deignan, J. Kelly, A. Alwan, C. O'Farrelly. , Comparative analysis of methods of purification of egg yolk immunoglobin (IgY). , Food Agric Immunol, 12, 2000, p77-85 Journal Article, 2000 URL

Abuzakouk, M, Feighery, C, Kelleher, D, O'Briain, DS, Jones, E, Weir, D, Casey, E, O'Farrelly, C, Increased HLA-DR and CD44 antigen expression in the gut: evidence of extraarticular immunological activity in rheumatoid arthritis., The Journal of Rheumatology, 26, (9), 1999, p1869-76 Journal Article, 1999

Doherty, DG, Norris, S, Madrigal-Estebas, L, McEntee, G, Traynor, O, Hegarty, JE, O'Farrelly, C, The human liver contains multiple populations of NK cells, T cells, and CD3+CD56+ natural T cells with distinct cytotoxic activities and Th1, Th2, and Th0 cytokine secretion patterns., Journal of immunology (Baltimore, Md. : 1950), 163, (4), 1999, p2314-21 Journal Article, 1999 URL

Levelt, CN, de Jong, YP, Mizoguchi, E, O'Farrelly, C, Bhan, AK, Tonegawa, S, Terhorst, C, Simpson, SJ, High- and low-affinity single-peptide/MHC ligands have distinct effects on the development of mucosal CD8alphaalpha and CD8alphabeta T lymphocytes., Proceedings of the National Academy of Sciences of the United States of America, 96, (10), 1999, p5628-33. Journal Article, 1999 URL TARA - Full Text

Costello, P, Bresnihan, B, O'Farrelly, C, FitzGerald, O, Predominance of CD8+ T lymphocytes in psoriatic arthritis., The Journal of rheumatology, 26, (5), 1999, p1117-24. Journal Article, 1999

Flynn, L, Carton, J, Byrne, B, Kelehan, P, O'Herlihy, C, O'Farrelly, C, Optimisation of a technique for isolating lymphocyte subsets from human endometrium., Immunological investigations, 28, (4), 1999, p235-46 Journal Article, 1999

Crosbie, OM, Reynolds, M, McEntee, G, Traynor, O, Hegarty, JE, O'Farrelly, C, In vitro evidence for the presence of hematopoietic stem cells in the adult human liver., Hepatology (Baltimore, Md.), 29, (4), 1999, p1193-8 Journal Article, 1999 URL DOI

Norris, S, Doherty, DG, Collins, C, McEntee, G, Traynor, O, Hegarty, JE, O'Farrelly, C, Natural T cells in the human liver: cytotoxic lymphocytes with dual T cell and natural killer cell phenotype and function are phenotypically heterogenous and include Valpha24-JalphaQ and gammadelta T cell receptor bearing cells., Human immunology, 60, (1), 1999, p20-31 Journal Article, 1999 URL DOI

E. Healy, M. Leonard, L. Madrigal-Estebas, C. O'Farrelly, A. Watson, M. Ryan, Factors produced by activated leukocytes alter renal epithelial cell differentiation., Kidney International , 56, 1999, p1266-1269 Journal Article, 1999 URL DOI

A. Alwan, T. Deignan, M. O'Sullivan, J. Kelly, C. O'Farrelly, Quantitative assay of Salmonella adherence to intestinal epithelial cells: a new method for assessing novel intervention products., J Microbiological Methods, 33, (1), 1998, p163-170. Journal Article, 1998 DOI URL

O'Farrelly C, Just how inflamed is the normal gut?, Gut, 42, (5), 1998, p603-4 Journal Article, 1998 TARA - Full Text

Feighery, C, Weir, DG, Whelan, A, Willoughby, R, Youngprapakorn, S, Lynch, S, O'Moráin, C, McEneany, P, O'Farrelly, C, Diagnosis of gluten-sensitive enteropathy: is exclusive reliance on histology appropriate?, European journal of gastroenterology & hepatology, 10, (11), 1998, p919-25 Journal Article, 1998

Abuzakouk, M, Carton, J, Feighery, C, O'Donoghue, DP, Weir, DG, O'Farrelly, C, CD4+ CD8+ and CD8alpha+ beta- T lymphocytes in human small intestinal lamina propria., European journal of gastroenterology & hepatology, 10, (4), 1998, p325-9 Journal Article, 1998

Crosbie, OM, Costello, PJ, O'Farrelly, C , Hegarty, JEC, Changes in peripheral blood double-negative T-lymphocyte (CD3+ CD4- CD8-) populations associated with acute cellular rejection after liver transplantation., Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 4, (2), 1998, p141-5 Journal Article, 1998 DOI URL

Crosbie, OM, Norris, S, Hegarty, JE, O'Farrelly, C, T lymphocyte subsets and activation status in patients following liver transplantation., Immunological investigations, 27, (4-5), 1998, p237-41 Journal Article, 1998 URL

Srinivasan, U, Weir, DG, Feighery, C, O'Farrelly, C, Emergence of classic enteropathy after longstanding gluten sensitive oral ulceration., BMJ (Clinical research ed.), 316, (7126), 1998, p206-7 Journal Article, 1998 URL TARA - Full Text

Norris, S, Collins, C, Doherty, DG, Smith, F, McEntee, G, Traynor, O, Nolan, N, Hegarty, J, O'Farrelly, C, Resident human hepatic lymphocytes are phenotypically different from circulating lymphocytes., Journal of hepatology, 28, (1), 1998, p84 - 90 Journal Article, 1998 Other

L. Madrigal-Estebas, R. McManus, B. Byrne, S. Lynch, D. G. Doherty, D. Kelleher, D. P. O'Donoghue, C. Feighery and C. O'Farrelly, Human small intestinal epithelial cells secrete interleukin-7 and differentially express two different interleukin-7 mRNA Transcripts: implications for extrathymic T-cell differentiation, Human Immunology, 58, (2), 1997, p83-90 Journal Article, 1997 DOI

Norris, S, Lawler, M, McCann, S, Hegarty, J, O'Farrelly, C, Donor type microchimerism is an infrequent event following liver transplantation and is not associated with graft acceptance., Hepatology (Baltimore, Md.), 26, (4), 1997, p848-52 Journal Article, 1997 DOI URL

Srinivasan, U, Leonard, N, Jones, E, Kasarda, DD, Weir, DG, O'Farrelly, C, Feighery, C, Absence of oats toxicity in adult coeliac disease., BMJ (Clinical research ed.), 313, (7068), 1996, p1300-1 Journal Article, 1996 TARA - Full Text URL

Reynolds, JV, O'Farrelly, C, Feighery, C, Murchan, P, Leonard, N, Fulton, G, O'Morain, C, Keane, FB, Tanner, WA, Impaired gut barrier function in malnourished patients., The British journal of surgery, 83, (9), 1996, p1288-1291 Journal Article, 1996 DOI URL

Abuzakouk, M, Kelleher, D, Feighery, C, O'Farrelly, C, Increased HLA-DR and decreased CD3 on human intestinal intraepithelial lymphocytes: evidence of activation?, Gut, 39, (3), 1996, p396-400 Journal Article, 1996 TARA - Full Text

Collins, C, Norris, S, McEntee, G, Traynor, O, Bruno, L, von Boehmer, H, Hegarty, J, O'Farrelly, C, RAG1, RAG2 and pre-T cell receptor alpha chain expression by adult human hepatic T cells: evidence for extrathymic T cell maturation., European journal of immunology, 26, (12), 1996 Journal Article, 1996 DOI

Abuzakouk, M, Feighery, C, O'Farrelly, C, Collagenase and Dispase enzymes disrupt lymphocyte surface molecules., Journal of immunological methods, 194, (2), 1996, p211-6. Journal Article, 1996 DOI URL

J. McDevitt, C. Feighery, C. O'Farrelly, G. Martin, D.G. Weir, D.K. Kelleher. , Effects of tumour necrosis factor on BrdU incorporation in cultured human enterocytes., The Journal of Biological Chemistry, 4, 1995, p31-37 Journal Article, 1995 DOI TARA - Full Text

Lynch, S, Kelleher, D, McManus, R, O'Farrelly, C, RAG1 and RAG2 expression in human intestinal epithelium: evidence of extrathymic T cell differentiation., European journal of immunology, 25, (5), 1995, p1143-7 Journal Article, 1995 URL DOI

S. Lynch, D. Kelleher, R. McManus and C. O'Farrelly, RAG1 and RAG2 expression in human intestinal epithelium: evidence of extrathymic T cell differentiation, European journal of immunology, 25, (5), 1995, p1143-1147 Journal Article, 1995 DOI URL

Kelleher, D, Murphy, A, Lynch, S, O'Farrelly, C, Adhesion molecules utilized in binding of intraepithelial lymphocytes to human enterocytes., European journal of immunology, 24, (4), 1994, p1013-6 Journal Article, 1994 DOI URL

Lawler M, Humphries P, O'Farrelly C, Hoey H, Sheils O, Jeffers M, O'Briain DS, Kelleher D., Adenovirus 12 E1A gene detection by polymerase chain reaction in both the normal and coeliac duodenum., Gut. , 35, (9), 1994, p1226-1232 Journal Article, 1994 DOI TARA - Full Text

J. McDevitt, C. O'Farrelly, D.G. Weir, M. Bishr Omary, C. Feighery, D. Kelleher, Proliferation-associated marker in the coeliac duodenum, Eur J Gastroenterol Hepatol, 6, (3), 1994, p223-228 Journal Article, 1994 URL

Madrigal, L, Lynch, S, Feighery, C, Weir, D, Kelleher, D, O'Farrelly, C, Flow cytometric analysis of surface major histocompatibility complex class II expression on human epithelial cells prepared from small intestinal biopsies., Journal of immunological methods, 158, (2), 1993, p207-14 Journal Article, 1993

S. Lynch, D. Kelleher, C. Feighery, D. Weir, C. O'Farrelly, Flow cytometric analysis of intraepithelial lymphocytes from human small intestinal biopsies reveals populations of CD4+CD8+ and CD8 Ñ Ñ+cells., Eur J Gastroenterol Hepatol , 5, 1993, p907-912 Journal Article, 1993 URL

O'Farrelly, C, Branton, D, Wanke, CA, Oral ingestion of egg yolk immunoglobulin from hens immunized with an enterotoxigenic Escherichia coli strain prevents diarrhea in rabbits challenged with the same strain., Infection and immunity, 60, (7), 1992, p2593-7 Journal Article, 1992 URL TARA - Full Text

O'Farrelly, C, O'Mahony, C, Graeme-Cook, F, Feighery, C, McCartan, BE, Weir, DG, Gliadin antibodies identify gluten-sensitive oral ulceration in the absence of villous atrophy., Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 20, (10), 1991, p476-8 Journal Article, 1991

O'Farrelly, C, Price, R, McGillivray, AJ, Fernandes, L, IgA rheumatoid factor and IgG dietary protein antibodies are associated in rheumatoid arthritis., Immunological investigations, 18, (6), 1989, p753-64 Journal Article, 1989

O'Farrelly, C, Marten, D, Melcher, D, McDougall, B, Price, R, Goldstein, AJ, Sherwood, R, Fernandes, L, Association between villous atrophy in rheumatoid arthritis and a rheumatoid factor and gliadin-specific IgG., Lancet, 2, (8615), 1988, p819-22 Journal Article, 1988

McCormick, PA, Feighery, C, Dolan, C, O'Farrelly, C, Kelliher, P, Graeme-Cook, F, Finch, A, Ward, K, Fitzgerald, MX, O'Donoghue, DP, Altered gastrointestinal immune response in sarcoidosis., Gut, 29, (12), 1988, p1628-31 Journal Article, 1988 URL TARA - Full Text

Kelly, J, O'Farrelly, C, Rees, JP, Feighery, C, Weir, DG, Humoral response to alpha gliadin as serological screening test for coeliac disease., Archives of disease in childhood, 62, (5), 1987, p469-73 Journal Article, 1987 TARA - Full Text URL

O'Farrelly, C, Graeme-Cook, F, Hourihane, DO, Feighery, C, Weir, DG, Histological changes associated with wheat protein antibodies in the absence of villous atrophy., Journal of Clinical Pathology, 40, (10), 1987, p1228-30 Journal Article, 1987 URL TARA - Full Text

Mealy, K, O'Farrelly, C, Stephens, R, Feighery, C, Impaired neutrophil function during anesthesia and surgery is due to serum factors., The Journal of surgical research, 43, (5), 1987, p393-7 Journal Article, 1987 URL

Kelly, J, O'Farrelly, C, O'Mahony, C, Weir, DG, Feighery, C, Immunoperoxidase demonstration of the cellular composition of the normal and coeliac small bowel., Clinical and experimental immunology, 68, (1), 1987, p1228-30 Journal Article, 1987 URL TARA - Full Text

O'Farrelly, C, Feighery, C, O'Briain, DS, Stevens, F, Connolly, CE, McCarthy, C, Weir, DG, Humoral response to wheat protein in patients with coeliac disease and enteropathy associated T cell lymphoma., British medical journal (Clinical research ed.), 293, (6552), 1986, p908-10 Journal Article, 1986 URL TARA - Full Text

Watson, RG, McMillan, SA, Dolan, C, O'Farrelly, C, Cuthbert, RJ, Haire, M, Weir, DG, Porter, KG, Gliadin antibody detection in gluten enteropathy., The Ulster medical journal, 55, (2), 1986, p160-4 Journal Article, 1986 URL TARA - Full Text

O'Farrelly, C, Whelan, CA, Feighery, CF, Weir, DG, Suppressor-cell activity in coeliac disease induced by alpha-gliadin, a dietary antigen., Lancet, 2, (8415), 1984, p1305-7 Journal Article, 1984 DOI

O'Farrelly, C, McKeever, U, Feighery, C, Weir, DG, Increased concanavalin A induced suppression in treated and untreated coeliac disease., Gut, 25, (6), 1984, p644-8 Journal Article, 1984 URL TARA - Full Text

O'Farrelly, C, Kelly, J, Hekkens, W, Bradley, B, Thompson, A, Feighery, C, Weir, DG, Alpha gliadin antibody levels: a serological test for coeliac disease., British medical journal (Clinical research ed.), 286, (6383), 1983, p2007-10 Journal Article, 1983 URL TARA - Full Text

O'Farrelly, C, Hekkens, WT, Feighery, C, Weir, DG, The specificity of wheat protein reactivity in coeliac disease., Scandinavian journal of gastroenterology, 18, (5), 1983, p603-7 Journal Article, 1983

O'Farrelly, C, Feighery, C, Greally, JF, Weir, DG, Cellular response to alpha-gliadin in untreated coeliac disease., Gut, 23, (1), 1982, p83-7 Journal Article, 1982 URL DOI TARA - Full Text

Non-Peer-Reviewed Publications

Orla Convery, Siobhan Gargan, Michelle Kickham, Martina Schroder, Cliona O'Farrelly and Nigel J. Stevenson, The hepatitis C virus (HCV) protein, p7, suppresses inflammatory responses to tumor necrosis factor (TNF)- a via signal transducer and activator of transcription (STAT)3 and extracellular signal-regulated kinase (ERK) - mediated induction of suppressor of cytokine signaling (SOCS)3, The FASEB Journal, Aug, 2019, p8732 - 8744 Journal Article, 2019 DOI

Orla Convery, Siobhan Gargan, Michelle Kickham, Martina Schroder, Cliona O'Farrelly and Nigel J. Stevenso, The hepatitis C virus (HCV) protein, p7, suppresses inflammatory responses to tumor necrosis factor (TNF)- a via signal transducer and activator of transcription (STAT)3 and extracellular signal-regulated kinase (ERK) - mediated induction of suppressor of cytokine signaling (SOCS)3, The FASEB Journal, Aug, 2019, p8732 - 8744 Journal Article, 2019 TARA - Full Text DOI

Innate immune mechanisms in the liver. in, editor(s)Gershwin ME, Vierling JM, Manns MP , Liver Immunology: Principles and Practices, New Jersey, Humana Press, 2007, pp41-48 , [O'Farrelly C, Doherty DG. ] Book Chapter, 2007

A short primer on fundamental immunology in, editor(s)Gershwin ME, Vierling JM, Manns MP , Liver Immunology: Principles and Practices, New Jersey, Humana Press, 2007, pp15-24 , [O'Farrelly C, Doherty DG. ] Book Chapter, 2007

Lymphocyte repertoires in healthy liver. in, editor(s)Gershwin ME, Vierling JM, Manns MP , Liver Immunology, Philadelphia, Hanley & Belfus, 2003, pp31-46 , [Doherty DG, O'Farrelly C.] Book Chapter, 2003

Research Expertise

Projects

  • Title
    • SFI Research Frontiers 2008 08/RFP/BMT1403
  • Summary
    • The role of Hepatitis C Virus in regulating Signal Transducer and Activator of Transcription (STAT) protein expression to evade anti-viral Interferon-á responses.
  • Funding Agency
    • SFI
  • Date From
    • 2008
  • Title
    • HRB Project Grant 2007 RP/2007/278
  • Summary
    • Suppressor of Cytokine Signalling (SOCS) Protein Involvement in Chronic Hepatitis C Virus (HCV) Infection and Failure to Respond to Interferon Alpha Therapy
  • Funding Agency
    • HRB
  • Date From
    • 2007
  • Title
    • HRB Translational Research Award 2007 TRA/2007/14
  • Summary
    • (with Dr. Aideen Long TCD & Prof. Dermot Kelleher, TCD) Immune targeting strategies: improving the response rate to IFN-alpha/ribavirin therapy in chronic Hepatitis C Virus infection
  • Funding Agency
    • HRB
  • Date From
    • 2007
  • Title
    • Dept. Agriculture Research Stimulus Fund 2006 06/340
  • Summary
    • Structural and functional identification of candidate immune genes for resistance to mastitis and metritis
  • Funding Agency
    • Dept. Agriculture
  • Date From
    • 2006
  • Title
    • FIRM Grant 2006 06/RDD/486
  • Summary
    • Identification of genes responsible for natural host resistance to Campylobacter colonisation tools to identify and breed genetically resistant chickens
  • Funding Agency
    • FIRM Grant
  • Date From
    • 2006
  • Title
    • Enterprise Ireland Proof of Concept phase Winter Call 2005 PC/2005/242
  • Summary
    • Evolution based approaches to directed alteration of AMPs for improved efficacy against Propionibacterium acnes and MRSA
  • Funding Agency
    • Enterprise Ireland
  • Date From
    • 2005
  • Title
    • SFI Research Frontiers Programme 2005 05/RFP/BIC0012
  • Summary
    • Role of CD1d isoforms and reactive cells in regulating immune responses to malignancy
  • Funding Agency
    • SFI
  • Date From
    • 2005
  • Title
    • HRB Research Project Grants - General 2005 RP/2005/217
  • Summary
    • (with Dr. Clair Gardiner, T.C.D. & HCV Research Consortium) Investigation of KIR genotype in the resolution of HCV infection
  • Date From
    • 2005
  • Title
    • Liver Trust S.V.U.H.
  • Summary
    • Identification and characterisation of hepatic features prognostic of disease progress in transplant rejection and Hepatitis C
  • Date From
    • 2004
  • Title
    • FIRM Grant 2004 04/R&D/D/295
  • Summary
    • Functional immunogenomics in the chicken: relevance to avian influenza virus infection
  • Funding Agency
    • FIRM
  • Date From
    • 2004
  • Title
    • HRB Research Programme Grant 2003 BPRO/02/2003
  • Summary
    • Characterisation Hepatitis C Induced Immunological Subversion and its Implications for Treatment Response
  • Funding Agency
    • HRB
  • Date From
    • 2003
  • Title
    • Enterprise Ireland Basic Research Grant Programme 2003 SC/2003/567
  • Summary
    • Cytokine Milieu, Natural Killer Receptor Positive Cells, Haematopoietic Progenitors in Human Endometrium
  • Funding Agency
    • Enterprise Ireland
  • Date From
    • 2003
  • Title
    • HRB Research Project Grants General 2001RP141/2001
  • Summary
    • Adult Stem Cells: Development of T Cells in the Human Intestine
  • Funding Agency
    • HRB
  • Date From
    • 2001
  • Title
    • FIRM Programme Grant 200101/R&D/D/135
  • Summary
    • Antimicrobial activity in Hen Eggs, a Combined Bioinformatic, Biochemical and Molecular Biological Approach
  • Funding Agency
    • FIRM
  • Date From
    • 2001
  • Title
    • Enterprise Ireland/British Council 2000: (for promoting collaboration):
  • Summary
    • Adult Stem Cells in Human Liver (with Prof. A. Strain, Birmingham University)
  • Funding Agency
    • Enterprise Ireland/British Council
  • Date From
    • 2000
  • Title
    • HRB Project Grant 2000 RP86/2000
  • Summary
    • Quantification of Hepatitis C Viral load in lymphocyte subpopulations (with John Hegarty)
  • Funding Agency
    • HRB
  • Date From
    • 2000
  • Title
    • Enterprise Ireland Grant 1999 SC/1999/345
  • Summary
    • The effect of intestinal epithelial microenvironment on T cell activation (with Dr. D. O'Donoghue)
  • Date From
    • 1999
  • Title
    • Irish Cancer Society Grant 1999 CRAB 1999/2000
  • Summary
    • Natural T cells in human bone marrow and their role in haematopoietic malignancy (with Dr. D. McCarthy)
  • Funding Agency
    • Irish Cancer Society
  • Date From
    • 1999
  • Title
    • HRB (Project Grant) 1999 165/99
  • Summary
    • Streptococcus Mutans adherence to hydroxyapatite beads and its prevention (with Dr. L. Fenelon)
  • Funding Agency
    • HRB
  • Date To
    • 1999
  • Title
    • Enterprise Ireland Grant 1999 ST/1999/150
  • Summary
    • Characterisation of novel antimicrobial proteins for inclusion in oral healthcare products (with Mr. M. Folan)
  • Funding Agency
    • Enterprise Ireland
  • Date From
    • 1999
  • Title
    • HRB (Grant in aid) 1998
  • Summary
    • T Lymphocyte differentiation in adult human liver (with Dr. J. Hegarty)
  • Funding Agency
    • HRB
  • Date From
    • 1998
  • Title
    • Dept. Agriculture Functional Foods Programme
  • Summary
    • Novel Antibacterial factors from Hen Eggs
  • Funding Agency
    • Dept. Agriculture Functional Foods Programme
  • Date From
    • 1997
  • Title
    • H.R.B. (Grant-in-aid)
  • Summary
    • Prevention of C.difficile infection with egg (with Dr. L. Fenelon)
  • Funding Agency
    • HRB
  • Date From
    • 1997
  • Title
    • H.R.B. (Grant-in-aid)
  • Summary
    • T cell populations in the human uterus (with Prof. C.O'Herlihy)
  • Funding Agency
    • HRB
  • Date From
    • 1996
  • Title
    • FORBAIRT Basic Grant
  • Summary
    • Unconventional T lymphocytes in the intestine
  • Funding Agency
    • FORBAIRT
  • Date From
    • 1996
  • Title
    • H.R.B. (Grant-in-aid) 1995
  • Summary
    • Cytokine Elaboration by Intestinal Epithelial Cells
  • Funding Agency
    • HRB
  • Date From
    • 1995
  • Title
    • FORBAIRT Strategic Development Award
  • Summary
    • Prevention of neonatal scour using probiotic bacteria and hen egg antibodies (with Dr. M.O'Sullivan)
  • Funding Agency
    • FORBAIRT
  • Date From
    • 1994
  • Title
    • H.R.B. (Grant-in-aid)
  • Summary
    • The liver as a site of extrathymic T cell differentiation
  • Funding Agency
    • HRB
  • Date From
    • 1994
  • Title
    • EOLAS Higher Education Industry Co-operation grant 1994
  • Summary
    • EOLAS Higher Education Industry Co-operation grant 1994: Passive immunisation of pigs against scour (with Dr. J. Kelly)
  • Funding Agency
    • EOLAS Higher Education Industry Co-operation
  • Date From
    • 1994
  • Title
    • H.R.B. (Grant-in-aid)
  • Summary
    • The gastrointestinal tract: a site of extrathymic T cell differentiation
  • Date From
    • 1993
  • Title
    • EOLAS/British Council Research
  • Summary
    • EOLAS/British Council Research Exchange Scheme (with Dr. P. Bland) 1993
  • Funding Agency
    • EOLAS/British Council Research
  • Date From
    • 1993
  • Title
    • D.I.T. Strategic Research and Development Grant
  • Summary
    • (with Dr. J. Kelly): Passive oral immunisation of pigs against scour using specific egg immunoglobulin
  • Funding Agency
    • DIT
  • Date From
    • 1992
  • Title
    • H.R.B. (Fellowship)
  • Summary
    • Human GI epithelial cells and their role in extrathymic T lymphocyte differentiation
  • Funding Agency
    • HRB
  • Date From
    • 1991
  • Title
    • H.R.B. (Grant-in-aid)
  • Summary
    • Phenotype and functional analysis of intraepithelial lymphocytes from coeliac small intestinal biopsies
  • Funding Agency
    • HRB
  • Date From
    • 1991
  • Title
    • The Arthritis Foundation of Ireland,
  • Summary
    • Dietary Antigens and the Gut in Rheumatoid Arthritis
  • Funding Agency
    • The Arthritis Foundation of Ireland,
  • Date From
    • 1990
  • Title
    • H.R.B. (Grant-in-aid)
  • Summary
    • Antigen presentation by normal and coeliac small intestinal epithelial cells
  • Funding Agency
    • HRB
  • Date From
    • 1990

Keywords

Animal Diseases/Pathology; Animal Reproductive Biology; Biomedical sciences; Chronic inflamation; Equine Diseases/Pathology; Food Safety; Hepatitis C; Host, Pathogen interactions; Human genetics; IMMUNE CELLS; Immune system; IMMUNE-MEDIATED; IMMUNOCOMPETENT CELLS; INFECTION; Infectious diseases; Infertility; INFLAMMATION; INNATE IMMUNE-SYSTEM; INNATE IMMUNITY; Innate immunology; Leukocyte Biology; Liver diseases and transplantation; Mucosal immunology; Poultry Products; Poultry Science; Reproduction, fertility and contraception; Stem Cell biology and hematopoiesis; Transplantation immunology, tolerance and rejection; Tumour immunology and immunotherapy; Vaccines; Virology and viral pathogenesis

Recognition

Awards and Honours

Irish Society Immunology Public Lecture Award 2008

Isla Haliday Memorial Lecture 2004

Conway Lecturer and Medallist 2004

President, Irish Society of Immunology 2001-2007

Thomas Davis Lecturer 1999

Irish Research Scientists Association Gold Medal 1998

Grave's Lecturer and Medallist 1997

Fellow Royal Academy of Medicine of Ireland 1997

Memberships

Irish Society of Immunology 1984 – present