Professor Niamh O'Connell
Clinical Professor, Clinical Medicine
Publications and Further Research Outputs
Peer-Reviewed Publications
Kennedy M, O'Gorman P, Monaghan A, Lavin M, O'Mahony B, O'Connell N.M, O'Donnell J.S, Turecek P.L, Gormley J, A systematic review of physical activity in people with haemophilia and its relationship with bleeding phenotype and treatment regimen, Haemophilia, 27, (4), 2021, p544 - 562
Doherty D, Lavin M, O'Sullivan JM, Ryan K, O'Connell NM, Dougall A, Byrne M, Rafferty M, Doyle MM, Di Paola J, James PD, O'Donnell JS, Management of elective procedures in low von Willebrand factor patients in the LoVIC study., Journal of thrombosis and haemostasis : JTH, 2021
Townsend L, Fogarty H, Dyer A, Martin-Loeches I, Bannan C, Nadarajan P, Bergin C, O' Farrelly C, Conlon N, Bourke NM, Ward SE, Byrne M, Ryan K, O' Donnell JS, Prolonged elevation of D-dimer Levels in Convalescent COVID-19 patients is Independent of the Acute Phase Response., Journal of thrombosis and haemostasis : JTH, 2021
Kempton C, Trask P, Parnes A, Niggli M, Campinha-Bacote A, U Callaghan M, O'Connell N, Paz-Priel I, Mahlangu JN, Development and testing of the Satisfaction Questionnaire with Intravenous or Subcutaneous Hemophilia Injection and results from the Phase 3 HAVEN 3 study of emicizumab prophylaxis in persons with haemophilia A without FVIII inhibitors., Haemophilia : the official journal of the World Federation of Hemophilia, 2021
O'Donovan M, Bergin C, Quinn E, Singleton E, Roche S, Benson J, Bird R, Byrne M, Duggan C, Gilmore R, Ryan K, O'Donnell JS, O'Connell NM, Real-world outcomes with recombinant factor IX Fc fusion protein (rFIXFc) prophylaxis: Longitudinal follow-up in a national adult cohort., Haemophilia : the official journal of the World Federation of Hemophilia, 2021
Helen Fogarty, Liam Townsend, Cliona Ni Cheallaigh, Colm Bergin, Ignacio Martin‐Loeches, Paul Browne, Christopher L Bacon, Richard Gaule, Alexander Gillett, Mary Byrne, Kevin Ryan, Niamh O'Connell, Jamie M O'Sullivan, Niall Conlon, James S O'Donnell, COVID 19 coagulopathy in caucasian patients, British Journal of Haematology, 89, (6), 2020, p1044 - 1049
Steven W. Pipe, Michael Recht, Nigel S. Key, Frank W.G. Leebeek, Giancarlo Castaman, Susan U. Lattimore, Paul Van Der Valk, Kathelijne Peerlinck, Michiel Coppens, Niamh O'Connell, John Pasi, Peter Kampmann, Karina Meijer, Annette von Drygalski, Guy Young, Cedric Hermans, Jan Astermark, Robert Klamroth, Richard S. Lemons, Nathan Visweshwar, Shelley Crary, Rashid Kazmi, Emily Symington, Miguel A. Escobar, Esteban Gomez, Rebecca Kruse-Jarres, Adam Kotowski, Doris Quon, Michael Wang, Allison P. Wheeler, Eileen K Sawyer, Stephanie Verweij, Valerie Colletta, Naghmana Bajma, Robert Gut, Wolfgang A. Miesbach, First Data from the Phase 3 HOPE-B Gene Therapy Trial: Efficacy and Safety of Etranacogene Dezaparvovec (AAV5-Padua hFIX variant; AMT-061) in Adults with Severe or Moderate-Severe Hemophilia B Treated Irrespective of Pre-Existing Anti-Capsid Neutralizing Antibodies, The American Society of Hematoloy, Dec 2020, 2020
Fogarty, Helen, Townsend, Liam, Ni Cheallaigh, Cliona, Bergin, Colm, Martin"Loeches, Ignacio, Browne, Paul, Bacon, Christopher L., Gaule, Richard, Gillett, Alexander, Byrne, Mary, Ryan, Kevin, O'Connell, Niamh, O'Sullivan, Jamie M., Conlon, Niall, O'Donnell, James S., More on COVID"19 coagulopathy in Caucasian patients, British Journal of Haematology, 189, (6), 2020, p1060-1061
O'Donovan M, Buckley C, Benson J, Roche S, McGowan M, Parkinson L, Byrne P, Rooney G, Bergin C, Walsh D, Bird R, McGroarty F, Fogarty H, Smyth E, O'Connell NM, Telehealth for delivery of haemophilia comprehensive care during the COVID-19 pandemic., Haemophilia : the official journal of the World Federation of Hemophilia, 2020
Aguila S, Lavin M, Dalton N, Patmore S, Chion A, Trahan GD, Jones KL, Keenan C, Brophy TM, O'Connell NM, Ryan K, Byrne M, Nolan M, Patel A, O'Donnell JS, Increased galactose expression and enhanced clearance in patients with low von Willebrand factor., Blood, 2019
Niamh M. O{', Acquired Factor Xiii Deficiency: An Uncommon But Easily Missed Cause Of Severe Bleeding, Irish medical journal, 2018
Fogarty H, Doyle MM, Campbell R, Keenan C, White B, Ryan K, O'Donnell JS, Slevin J, O'Keeffe D, O'Connell NM, Lavin M, Management of combined factor V and factor VIII deficiency in pregnancy., Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2018
Doherty D, Singleton E, Byrne M, Ryan K, O'Connell NM, O'Donnell JS, Lavin M, Missed at first Glanz: Glanzmann thrombasthenia initially misdiagnosed as Von Willebrand Disease., Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis, 2018
Lavin M, Aguila S, Dalton N, Nolan M, Byrne M, Ryan K, White B, O'Connell NM, O'Sullivan JM, Di Paola J, James PD, O'Donnell JS, Significant gynecological bleeding in women with low von Willebrand factor levels., Blood advances, 2018
Kevane B, O'Connell N, The current and future role of plasma-derived clotting factor concentrate in the treatment of haemophilia A., Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis, 2018
Appleby, N., Groarke, E., Crowley, M., Wahab, F. A., McCann, A. M., Egan, L., Gough, D., McMahon, G., O'Donghaile, D., O'Keeffe, D., O'Connell, N., Reversal of warfarin anticoagulation using prothrombin complex concentrate at 25 IU kg"1 : results of the RAPID study, Transfusion Medicine, 27, (1), 2017, p66-71
Lavin M, Aguila S, Schneppenheim S, Dalton N, Jones KL, O'Sullivan JM, O'Connell NM, Ryan K, White B, Byrne M, Rafferty M, Doyle MM, Nolan M, O'Donnell JS, Novel insights into the clinical phenotype and pathophysiology underlying low VWF levels., Blood, 2017
Lavin, M. and Ryan, K. and White, B. and Byrne, M. and O'Connell, N.M. and O'Donnell, J.S., A role for intravenous immunoglobulin in the treatment of Acquired Von Willebrand Syndrome associated with IgM gammopathy, Haemophilia, 2017, pe22-e25
Grogan A, Coughlan M, Prizeman G, O'Connell N, O'Mahony N, Quinn K, McKee G, The patients' perspective of international normalized ratio self-testing, remote communication of test results and confidence to move to self-management., Journal of clinical nursing, 2017
Lavin, M. and Kavanagh, J. and Beddy, P. and O'Connell, N.M. and O'Donnell, J.S., Recurrent lower limb venous thrombosis associated with a congenitally absent infrarenal inferior vena cava, QJM, 109, (1), 2016, p57
Lavin, M. and Jenkins, P.V. and Keenan, C. and White, B. and Betts, D.R. and O'Donnell, J.S. and O'Connell, N.M., X-linked moyamoya syndrome associated with severe haemophilia A, Haemophilia, 22, (1), 2016, pe51-e54
Lavin M, Brophy T.M, Rawley O, O'Sullivan J.M, Hayden P.J, Browne P.V, Ryan K, O'Connell N, O'Donnell J.S, Lenalidomide as a novel treatment for refractory acquired von Willebrand syndrome associated with monoclonal gammopathy, Journal of Thrombosis and Haemostasis, 14, (6), 2016, p1200 - 1205
C Logan, J Kavanagh, N O'Connell, N McEniff, JM Ryan, M Guiney, K Ryan, O Seery, J O'Donnell, B White., Out of sight, out of mind? An audit which proposes a follow-up and management pathway for Inferior Vena Cava Filters. , Thrombosis, MS No 483870, 2016, pdoi:10.1155/2016/6538456
Lavin, M. and Jenkins, P.V. and Healy, M.L. and Byrne, M. and O'Connell, N.M. and O'Donnell, J.S., Age-related factor IX correction in symptomatic female carriers with haemophilia B Leyden, Haemophilia, 21, (6), 2015, pe498-e500
O'Reilly MA, McHale C, Almazmi A, Hameed A, Benjamin D, O'Connell N, Murphy P, Quinn J, Thornton P, O'Gorman P, Frankova H, Sargent J, Verburgh E, McHugh J, Evans P, Enright H., A 5-day: the favourable way?, Annals of hematology, 93, (9), 2014, p1619-1620
O'Reilly MA, McHale C, Almazmi A, Hameed A, Benjamin D, O'Connell N, Murphy P, Quinn J, Thornton P, O'Gorman P, Frankova H, Sargent J, Verburgh E, McHugh J, Evans P, Enright H., A 5-day outpatient regimen of azacitidine is effective and well tolerated in patients with acute myeloid leukemia unsuitable for intensive chemotherapy., Leukemia & lymphoma, 55, (12), 2014, p2950-2951
Mumford AD, Ackroyd S, Alikhan R, Bowles L, Chowdary P, Grainger J, Mainwaring J, Mathias M, O'Connell N, BCSH Committee, Guideline for the diagnosis and management of the rare coagulation disorders: a United Kingdom Haemophilia Centre Doctors' Organization guideline on behalf of the British Committee for Standards in Haematology., British journal of haematology, 2014
O'Donnell DM, O'Connell NM, O'Donnell JS, Oral rivaroxaban for pulmonary embolism., The New England journal of medicine, 2012
Niamh M. O{', Allogeneic Hematopoietic Stem Cell Transplantation for a BCR-FGFR1 Myeloproliferative Neoplasm Presenting as Acute Lymphoblastic Leukemia., Case reports in hematology, 2012
Qasim A, Duggan M, O'Connell N, O'Driscoll A, Clinical conditions and patient factors significantly influence diagnostic utility of D-dimer in venous thromboembolism., Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2009
O'Connell NM, Riddell AF, Pascoe G, Perry DJ, Lee CA, Recombinant factor VIIa to prevent surgical bleeding in factor XI deficiency., Haemophilia : the official journal of the World Federation of Hemophilia, 2008
Kadir RA, Kingman CE, Chi C, O'connell NM, Riddell A, Lee CA, Economides DL, Screening for factor XI deficiency amongst pregnant women of Ashkenazi Jewish origin., Haemophilia : the official journal of the World Federation of Hemophilia, 2006
Hayden PJ, O'Connell NM, O'Brien DA, O'Rourke P, Lawlor E, Browne PV, The value of autofluorescence as a diagnostic feature of acute promyelocytic leukemia., Haematologica, 2006
O'Connell NM, Saunders RE, Lee CA, Perry DJ, Perkins SJ, Structural interpretation of 42 mutations causing factor XI deficiency using homology modeling., Journal of thrombosis and haemostasis : JTH, 2005
Saunders RE, O'Connell NM, Lee CA, Perry DJ, Perkins SJ, Factor XI deficiency database: an interactive web database of mutations, phenotypes, and structural analysis tools., Human mutation, 2005
Basic principles of coagulation in, editor(s)Denise O'Shaughnessy Michael Makris David Lillicrap , Practical Haemostasis, Oxford University Press, 2004, [Niamh O'Connell]
Salomon O, Zivelin A, Livnat T, Dardik R, Loewenthal R, Avishai O, Steinberg DM, Rosove MH, O'Connell N, Lee CA, Seligsohn U, Prevalence, causes, and characterization of factor XI inhibitors in patients with inherited factor XI deficiency., Blood, 2003
O'Connell NM, Perry DJ, Hodgson AJ, O'Shaughnessy DF, Laffan MA, Smith OP, Recombinant FVIIa in the management of uncontrolled hemorrhage., Transfusion, 2003
O'Connell NM, Factor XI deficiency--from molecular genetics to clinical management., Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2003
Laffan M, O'Connell NM, Perry DJ, Hodgson AJ, O'Shaughnessy D, Smith OP, Analysis and results of the recombinant factor VIIa extended-use registry., Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2003
Haematological emergencies in, editor(s)R.A.J.Spence P.Johnston , Oncological Emergencies, Oxford University Press, 2002, [Niamh O'Connell, Shaun R. McCann]
Y. L. Woo, B. White, R. Corbally, M. Byrne, N. O'Connell, E. O'Shea, B. L. Sheppard, J. Bonnar and O. P. Smith, von Willebrand's disease: an important cause of dysfunctional uterine bleeding, Blood coagulation & fibrinolysis, 13, (2), 2002, p89-93
Niamh M. O{', Childhood refractory autoimmune haemolytic anaemia: is there a role for anti-CD20 therapy (rituximab)?, British journal of haematology, 2002
N. O'Connell, J. Chen, M. Byrne, E. O'Shea, H. Smyth and O. P. Smith, Massive pseudotumour resection with recombinant factor VIIa (NovoSeven) cover, British journal of haematology, 116, (3), 2002, p645-8
N. O'Connell, C. Mc Mahon, J. Smith, K. Khair, I. Hann, R. Liesner and O. P. Smith, Recombinant factor VIIa in the management of surgery and acute bleeding episodes in children with haemophilia and high responding inhibitors, British journal of haematology, 116, (3), 2002, p632-5
Niamh M. O{', Fatal Pancreatic Necrosis after Pregnancy-Associated Thrombotic Thrombocytopenic Purpura., Hematology (Amsterdam, Netherlands), 2001
N. O'Connell, N. Gardiner, C. Duggan, H. Enright, M. J. Kennedy, S. R. McCann, P. A. Daly and P. V. Browne, Effective progenitor cell mobilization in lymphoproliferative disorders using ifosfamide, epirubicin and etoposide (IEV), European journal of haematology Supplementum, (64), 2001, p33-6
Grace A, O'Connell N, Byrne P, Prendiville W, O'Donnell R, Royston D, Walsh CB, Leader M, Kay E, Malignant lymphoma of the cervix. An unusual presentation and a rare disease., European journal of gynaecological oncology, 1999
Non-Peer-Reviewed Publications
Groarke E, O'Connell N, Practical management of venous thromboembolism in patients with cancer, Cancer Professional, 11, (1), 2017, p14 - 16
Bakhai A, Lip GH, McCormack T, Rose P, Eames M, O'Connell N, Harrison-Tiffin N, Fortes-Mayer G, Fitzmaurice D, Fay M, Defining consensus in anticoagulation service delivery for patients with atrial fibrillation, Prescriber, 2012
A. McCashin, Fact or Fiction?, Poverty Today [Combat Poverty Agency magazine], 1996, p11 - 12
Research Expertise
Recognition
Representations
Chair of the Irish Haematology Society Coagulation Special Interest group
Chair of the Haemophilia Product Selection and Monitoring advisory Board
Member of the National Haemophilia Council
Member of the Medical and Scientific Advisory Board of the Irish Blood Transfusion service
Grant application reviewer for the UK MRC
Member of the committee of the Haematology association of Ireland
Journal Reviewer (Haemophilia, Clinical and Applied Thrombosis and Haemostasis, American Journal of Hematology, Anesthesia and Analgesia Irish Medical Journal)
Advisor to the National Immunisation Advisory Committee
Awards and Honours
The Dr. Henry Hutchinson Stewart Scholarship in Anatomy
The Charles Medals in Anatomy and Physiology
The Pfizer Gold Medal in Psychiatry
The P.F. Fitzpatrick Prize in Social and Preventive medicine
The R.G.G. Barry prize in Paediatrics
The James M. O'Donovan Prize
The Blayney Prize
University College Cork Scholarships
Memberships
The Haematology Association of Ireland
The International Society for Thrombosis and Haemostasis
The World Federation of Haemophilia
The Irish Haematology Society
The U.K. Haemophilia Centre Doctors Organisation
The European Association for Haemophilia and Allied Disorders