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Dr. Cliona Ni Cheallaigh
Associate Professor Consultant, Clinical Medicine

Publications and Further Research Outputs

Peer-Reviewed Publications

Rikke Siersbaek; John Ford; Clíona Ní Cheallaigh;Sara Burke; Steve Thomas, How accessible is healthcare for single adults experiencing long-term homelessness and complex needs? A realist evaluation protocol, HRB Open Research , 2020 Journal Article, 2020 DOI

Bristowe, K., Murtagh, F. E. M., Clift, P., James, R., Josh, J., Platt, M., Whetham, J., Nixon, E., Post, F. A., McQuillan, K., Cheallaigh, C. Ní, Kall, M., Anderson, J., Sullivan, A. K., Harding, R., The development and cognitive testing of the positive outcomes HIV PROM: a brief novel patient-reported outcome measure for adults living with HIV, Health and Quality of Life Outcomes, 18, (1), 2020 Journal Article, 2020 DOI

Fogarty, Helen, Townsend, Liam, Ni Cheallaigh, Cliona, Bergin, Colm, Martin"Loeches, Ignacio, Browne, Paul, Bacon, Christopher L., Gaule, Richard, Gillett, Alexander, Byrne, Mary, Ryan, Kevin, O"Connell, Niamh, O"Sullivan, Jamie M., Conlon, Niall, O'Donnell, James S., COVID19 coagulopathy in Caucasian patients, British Journal of Haematology, 189, (6), 2020, p1044-1049 Journal Article, 2020 DOI

Fogarty, Helen, Townsend, Liam, Ni Cheallaigh, Cliona, Bergin, Colm, Martin"Loeches, Ignacio, Browne, Paul, Bacon, Christopher L., Gaule, Richard, Gillett, Alexander, Byrne, Mary, Ryan, Kevin, O'Connell, Niamh, O'Sullivan, Jamie M., Conlon, Niall, O'Donnell, James S., More on COVID"19 coagulopathy in Caucasian patients, British Journal of Haematology, 189, (6), 2020, p1060-1061 Journal Article, 2020 DOI

Grant, Conor, Bergin, Colm, O"Connell, Sarah, Cotter, John, Ní Cheallaigh, Clíona, High-Cost, High-Need Users of Acute Unscheduled HIV Care: A Cross-Sectional Study, Open Forum Infectious Diseases, 7, (2), 2020 Journal Article, 2020 DOI

Broderick J, Waugh A, Mc Govern M, Alpine L, Kiernan S, Murphy N, Hodalova D, Feehan S, Ní Cheallaigh C. , Addressing complex societal challenges in health education - A physiotherapy-led initiative embedding inclusion health in an undergraduate curriculum, HRB Open Research, 2, (22), 2019 Journal Article, 2019 URL TARA - Full Text DOI

Ni She E., Morton S., Lambert V., Ni Cheallaigh C., Lacey V., Dunn E., Loughnane C., O'Connor J., McCann A., Adshead M., Kroll T., Clarifying the mechanisms and resources that enable the reciprocal involvement of seldom heard groups in health and social care research: A collaborative rapid realist review process, Health Expectations, 2019 Journal Article, 2019 DOI

Ewins, Karl, Ni Ainle, Fionnuala, Ni Cheallaigh, Cliona, Dunlea, Eoghan, Kelliher, Sarah, Imbalzano, Egidio, Bortoluzzi, Cristiano, Jou, Inés, Alfonso-Megido, Joaquín, Díaz-Pedroche, María del Carmen, Monreal, Manuel, Higher Rates of Death and Major Bleeding Highlight the Inequities That Exist in the Care of People with Venous Thromboembolism Who Experience Social Exclusion: Findings from a Prospective Registry of 79735 Patients (RIETE), Blood, 134, (Supplement_1), 2019, p4677-4677 Journal Article, 2019 DOI

Carroll, Aine, O'Brien, Siobhan, Harrington, Deirdre, Cheallaigh, Cliona Ní, The unmet Rehabilitation needs in an Inclusion Health Integrated Care Programme for Homeless Adults in Dublin, Ireland, International Journal of Integrated Care, 19, (4), 2019, p13 Journal Article, 2019 DOI

McCrory, C., Fiorito, G., Layte, R., Vineis, P. & Kenny, R.A. , Epigenetic clocks and allostatic load reveal potential sex-specific drivers of biological ageing, Journal of Gerontology: Biological Sciences, 2019 Journal Article, 2019

Ewins, Karl, Ni Ainle, Fionnuala, Dunlea, Eoghan, Kelliher, Sarah, Sandys, Vicky, Rooney, Hannorah, Macken, Lily, Cliona, Ni Cheallaigh, Socially Excluded Persons in Ireland Have an Increased Annual Risk of Hospitalisation Due to Venous Thromboembolic Disease, Blood, 134, (Supplement_1), 2019, p4702-4702 Journal Article, 2019 DOI

Layte, R. and McCrory, C., Ni Cheallaigh, C., Bourke, N., Kivimaki, M., Ribeiro, A.I, Stringhini, S. and Vineis, P., A Comparative Analysis of the Status Anxiety Hypothesis of Socio-Economic Inequalities in Health Based on 18,349 individuals in Four Countries and Five Cohort Studies, Scientific Reports, Online, 2019, p1 - 6 Journal Article, 2019 URL

Bristowe, K, Clift, P, James, R, Josh, J, Platt, M, Whetham, J, Nixon, E, Post, FA, McQuillan, K, Ní Cheallaigh, C, Murtagh, FEM, Anderson, J, Sullivan, AK, Harding, R, Towards person"centred care for people living with HIV : what core outcomes matter, and how might we assess them? A cross"national multi"centre qualitative study with key stakeholders, HIV Medicine, 2019 Journal Article, 2019 DOI

Coleman MM, Basdeo SA, Coleman AM, Cheallaigh CN, Peral de Castro C, McLaughlin AM, Dunne PJ, Harris J, Keane J., All-trans Retinoic Acid Augments Autophagy during Intracellular Bacterial Infection., American journal of respiratory cell and molecular biology, 59, (5), 2018, p548-556 Journal Article, 2018 DOI

Ni Cheallaigh Cliona, Sheedy Frederick J., Shields Up: Systemic Protection Provided by microRNA-21 During Sepsis?, 45 , (7 ), 2017 Journal Article, 2017 URL

Ni Cheallaigh C, Kieran J, Cullivan C, Browne J, Kenny R, Bergin C, Byrne D, Usage of Unscheduled Hospital Care by Homeless Individuals in Dublin, Ireland: A Cross-Sectional Study, BMJ Open, 7, (e016420), 2017 Journal Article, 2017 DOI URL

Ní Cheallaigh C, O'Leary A, Keating S, Bergin C, Telementoring with project ECHO: a pilot study in Europe, BMJ Innovations, 3, (3), 2017, p144--151 Journal Article, 2017 DOI

Ní Cheallaigh, C., Sheedy, F.J., Harris, J., Muñoz-Wolf, N., Lee, J., West, K., McDermott, E.P., Smyth, A., Gleeson, L.E., Coleman, M., Martinez, N., Hearnden, C.H., Tynan, G.A., Carroll, E.C., Jones, S.A., Corr, S.C., Bernard, N.J., Hughes, M.M., Corcoran, S.E., O'Sullivan, M., Fallon, C.M., Kornfeld, H., Golenbock, D., Gordon, S.V., O'Neill, L.A., Keane, J. Lavelle, E.C, A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling., Immunity, 44, (2), 2016, p368 - 379 Journal Article, 2016 TARA - Full Text URL

Killick, K.E., Ní Cheallaigh, C., O'Farrelly, C., (...), Machugh, D.E., Harris, J., Receptor-mediated recognition of mycobacterial pathogens, Cellular Microbiology, 15, (9), 2013, p1484-1495 Journal Article, 2013 DOI

Peral de Castro C, Jones SA, Ní Cheallaigh C, Hearnden CA, Williams L, Winter J, Lavelle EC, Mills KH, Harris J, Autophagy Regulates IL-23 Secretion and Innate T Cell Responses through Effects on IL-1 Secretion., Journal of immunology (Baltimore, Md. : 1950), 189, (8), 2012, p4144-4153 Journal Article, 2012 DOI

Ní Cheallaigh C, Keane J, Lavelle EC, Hope JC, Harris J., Autophagy in the immune response to tuberculosis: clinical perspectives., Clinical and Experimental Immunology, 164, (3), 2011, p291 - 300 Journal Article, 2011 DOI TARA - Full Text

Non-Peer-Reviewed Publications

Ms Niamh Murphy, Surveillance Scientist, HPSCDr Lelia Thornton (Chair), Specialist in Public Health Medicine, HPSCDr Kate O'Donnell, Surveillance Scientist, HPSCDr Derval Igoe, Specialist in Public Health Medicine, HPSCProfessor Joe Barry, HSE/CTL/Trinity College DublinDr Margaret Bourke, GP Co-ordinator HSE Addiction Services Dublin Mid-LeinsterMr Emmett Conroy, Irish Prison ServiceDr Des Crowley, Assistant National Director Substance Misuse Programme, ICGPDr Cillian de Gascun, Director NVRLDr Margaret Fitzgerald, Public Health Lead National Social Inclusion, HSE Mr Brian Galvin, Head of Ireland's Focal Point for European Monitoring Centre for Drugs and Drug Addiction, HRB Evidence Cent Aidan Horan, Caroline Hurley, Shay Keating, Eamon Keenan, Suzi Lyons, Seán Millar, Cliona Ni Cheallaigh, Sinead Woods, , Drug-related bloodborne viruses in Ireland, 2018, Dublin, September, 2018 Report, 2018

Research Expertise

Projects

  • Title
    • COVID-19 Immunology Research Partnership
  • Funding Agency
    • SFI
  • Title
    • Premature Ageing in Long-Term Homeless Adults (PATH)
  • Funding Agency
    • HRB
  • Title
    • Premature Ageing in Long-Term Homeless Adults (PATH): Immunology
  • Funding Agency
    • Royal City of Dublin Hospital Trust
  • Title
    • Identifying Protective Immunity in Frontline Healthcare Staff During the COVID-19 Pandemic
  • Summary
    • A key issue during the ongoing SARS-CoV2 pandemic is to determine the proportion of the population possessing effective antibodies for virus clearance and long-term immunity. Screening post-infection immunity will identify key/frontline healthcare workers that can work without risk of re-infection. This assay will also be crucial to monitor the true scale of the pandemic as many infections will be mild/ asymptomatic without testing. Furthermore, with ongoing plasmapheresis trials using anti-SARS-CoV2 antibody-containing sera for critical COVID-19 patients, identifying donors with high levels of anti-viral antibody will be a valuable factor to assess. RNA-based qPCR diagnostic tests currently used in Ireland to detect SARS-COV2 viral RNA in a nose/throat swabs can sensitively detect active infection at an early stage of infection but cannot detect immunity to the virus after clearance. This can only be achieved using Immunoglobulin(Ig)-based tests for antibodies against key SARS-COV2 antigens (predominantly virion 'Spike' or S protein). While serological tests are in development for SARS-COV2 antibodies, few are approved for use and will likely be expensive with substantial delays in global distribution. A recent pre-print (Amanat et al., published 18 March 2020) described a novel assay for SARS-COV2 antibodies. The aim of this project is to establish this assay in Ireland, screen SARS-COV2 positive serum samples from Irish patients and determine its accuracy using a larger cohort of SARS-COV2 positive sera. If the method can be replicated, a non-accredited test could be developed to screen the Irish population for post-infection immunity in a rapid and cost-effective manner.
  • Funding Agency
    • SFI
  • Title
    • VIRCOA-TILDA
  • Summary
    • In this study, a comprehensive assessment of how past exposure to viruses impacts risk of COVID-19 in older people will be carried out and how it is linked to inflammageing and anti-viral immunity. A well-established longitudinal ageing cohort, TILDA, which has the detailed demographic, clinical and biomarker information - rich phenotyping data will be combined with a state-of-the-art approach, VirScanTM, to determine a person's complete viral exposure history.
  • Funding Agency
    • SFI
  • Date From
    • 01/12/2020
  • Date To
    • 30/11/2021
  • Title
    • Irish COVID-19 Vasculopathy Study (iCVS)
  • Summary
    • Novel coronavirus (COVID-19) pneumonia is associated with significant mortalitypredominantly attributable to a progressive bilateral pneumonia, that ultimately progresses to acute respiratory distress syndrome (ARDS) which is refractory to standard therapies. Previous multivariate regression analysis studies performed in Wuhan have shown that elevated plasma levels of fibrin degradation D-dimers constitute a key independent biomarker of poor prognosis in COVID-19. Interestinglyhowever, despite this prognostic increase in D-dimers, COVID-19 patients do not typically develop systemic disseminated intravascular coagulation (DIC). Nonetheless, post-mortem studies in COVID-19 infected patients have highlighted marked pathological changes restricted to within the lung microvasculature. These include disseminated micro-thrombi and haemorraghic necrosis. Cumulatively, these findings suggest that the refractory ARDS phenotype observed in COVID-19 is due in part to a novel pulmonary-specific vasculopathy. Critically however, pathobiological mechanisms underpinning this unique vasculopathy remain completely undefined.Although D-dimer levels are being used globally as prognostic marker in patients with COVID-19, no studies have sought to investigate why coagulation D-dimers areelevated, nor why D-dimer levels and coagulation activation correlate so strongly with clinical outcomes. In this cross-disciplinary IrishCOVID-19VasculopathyStudy (iCVS), we will systematically investigate the biological pathways that ultimately lead to elevated plasma D-dimer levels. These include (i) EC activation (ii) procoagulant cascade activation (iii) down-regulation of normal anticoagulant pathways (iv) fibrinolytic pathways (v) platelet activation respectively. The plan of investigation will define novel vascular biomarkers beyond crude D-dimers that can be used to betterdefine prognosis for COVID-19 patients and thereby prioritise ICU resources. In addition, elucidating the biology underlying the unique pulmonary vasculopathy involved in severe COVID-19 sepsis will identify subsets of patients likely to benefitfrom specific anti-inflammatory, anticoagulant and/or antiplatelet therapies respectively. Consequently, the proposed studies are not only of scientific interest,but directly address an important clinical unmet need.
  • Funding Agency
    • HRB

Keywords

Addiction and substance abuse; Age related diseases; Ageing, memory and other cognitive processes; Gerontology; Host, Pathogen interactions; Identification and quantification of health care needs; Innate immunology; Intra and intercellular signalling; Patterns of health; Sociological influences on health