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Professor Christopher (Larry) Bacon
Clinical Professor, Haematology

Publications and Further Research Outputs

Peer-Reviewed Publications

, Philadelphia chromosome-positive acute lymphoblastic leukemia with an e14a3 BCR-ABL1 fusion: The role of molecular monitoring, Hematology/oncology and stem cell therapy, 2020 Journal Article, 2020

, The Irish Experience of Thiotepa, Carmustine and Etoposide Conditioning Prior to ASCT for the Treatment of Central Nervous System Lymphomas, BONE MARROW TRANSPLANTATION, 2020 Journal Article, 2020

, Real-world experience of BRAF V600E mutation testing in hairy cell leukaemia, Journal of clinical pathology, 2020 Journal Article, 2020

Helen Fogarty, Liam Townsend, Cliona Ni Cheallaigh, Colm Bergin, Ignacio Martin‐Loeches, Paul Browne, Christopher L Bacon, Richard Gaule, Alexander Gillett, Mary Byrne, Kevin Ryan, Niamh O'Connell, Jamie M O'Sullivan, Niall Conlon, James S O'Donnell, COVID 19 coagulopathy in caucasian patients, British Journal of Haematology, 89, (6), 2020, p1044 - 1049 Journal Article, 2020

, A Phase 1b Study to Evaluate the Safety and Efficacy of Durvalumab in Combination with Tremelimumab or Danvatirsen in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma, Clinical Lymphoma Myeloma and Leukemia, 2020 Journal Article, 2020

Ta R, Santini C, Gou P, Lee G, Tai YC, O'Brien C, Fontecha M, Grant C, Bacon L, Finn S, Vandenberghe E, Quinn F, Dua R, Flavin R., Molecular Subtyping of Diffuse Large B-Cell Lymphoma Using a Novel Quantitative RT-PCR Assay , J Mol Diagn, 2020, pS1525-1578- Journal Article, 2020 URL

Shackleton L, Langabeer SE, O'Brien D, McCarron SL, Byrne B, Barry R, Flavin R, Bacon CL, Flynn CM., Hairy Cell Leukemia Masquerading as Pancytopenia in Pregnancy., Case reports in hematology, 2019, 2019, p3238168 Journal Article, 2019 DOI

, Blinatumomab versus chemotherapy in first salvage or in later salvage for B-cell precursor acute lymphoblastic leukemia, Leukemia & lymphoma, 2019 Journal Article, 2019

Rachel Brodie, Greg Lee, Valerie Broderick, Elizabeth Higgins, Richard Flavin, Nicole Gardiner, Patrick Hayden, Paul Browne, Eibhlin Conneally, Emma Tuohy, Catherine Flynn, Elisabeth Vandenberghe, Christopher Laurence Bacon, A baseline national study of allogeneic transplantation for high grade B-cell lymphoma (HGBL): An outcome baseline prior to the introduction of a CAR-T program, Bone Marrow Transplantation, 54, Nature Publishing Group, 2019, pp452 - 453 Conference Paper, 2019 DOI

Ta Robert, Santini Christopher, Gou Patricia, Lee Greg, O'Brien Cathal, Tai Yu, Fontecha Marcel, Grant Cliona, Bacon Larry, Finn Stephen, Vandenberghe Elisabeth, Flavin Richard, Molecular Subtyping of Diffuse Large B-Cell Lymphoma Using a Novel qRT-PCR Assay , Modern Pathology, 2019, 99 , NATURE PUBLISHING GROUP 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA , 2019 Conference Paper, 2019

, A NATIONAL RETROSPECTIVE ANALYSIS OF CLINICAL OUTCOMES FOLLOWING ALLOGENEIC TRANSPLANTATION FOR HIGH GRADE B-CELL LYMPHOMA (HGBL), Hematological Oncology, 2019 Journal Article, 2019

, Moxetumomab pasudotox in relapsed/refractory hairy cell leukemia, Leukemia, 2018 Journal Article, 2018

Langabeer SE, Haslam K, O'Brien D, Kelly J, Andrews C, Ryan C, Flavin R, Hayden PJ, Bacon CL, Acute Lymphoblastic Leukemia Arising in CALR Mutated Essential Thrombocythemia., Case reports in hematology, 2016 Journal Article, 2016

, Turning the Heat up a Notch in Biclonal Lymphoproliferative Disorders, 2016 Journal Article, 2016

, Viral Infection and Reactivation in Alemtuzumab Reduced Intensity Stem Cell Transplantation in lymphoid malignancies: a study from the Irish National Adult Stem Cell Transplant (NASCT) Unit, BONE MARROW TRANSPLANTATION, 2015 Journal Article, 2015

, Splenectomy-related red cell lysis resistance causing analytical difficulty in a patient with a hematological malignancy., Clinical laboratory, 2014 Journal Article, 2014

, Reaudit of Overnight Blood Transfusion in the Mater Misericordiae University Hospital (MMUH), IRISH JOURNAL OF MEDICAL SCIENCE, 2014 Journal Article, 2014

McHugh J, Storey L, Bacon L, O'Marcaigh A, O'Sullivan M, Smith O, Paediatric follicular lymphoma., 2013 Journal Article, 2013

Leahy TR, Smith OP, Bacon CL, Storey L, Lynam P, Gavin PJ, Butler KM, O'Marcaigh AS, Does vaccine dose predict response to the monovalent pandemic H1N1 influenza a vaccine in children with acute lymphoblastic leukemia? A single-centre study., 2013 Journal Article, 2013

, A multi-centre retrospective study of rituximab use in the treatment of relapsed or resistant warm autoimmune haemolytic anaemia, British journal of haematology, 2013 Journal Article, 2013

, Vincristine-induced vocal cord paralysis in a patient with acute lymphoblastic leukemia, Annals of hematology, 2012 Journal Article, 2012

Bacon, C.L., Singleton, E., Brady, B., White, B., Nolan, B., Gilmore, R.M., Ryan, C., Keohane, C., Vince Jenkins, P. and O'Donnell, Low risk of inhibitor formation in haemophilia A patients following en masse switch in treatment to a third generation full length plasma and albumin-free recombinant factor VIII product (ADVATE®), Haemophilia, 17, 2011, p407 - 411 Journal Article, 2011 DOI URL

Curry S, Bacon CL, Robinson I, Capra M, Smith OP., Leukaemic alveolar rhabdomyosarcoma., British journal of haematology, 151, (3), 2010, p208 Journal Article, 2010 DOI

, A Doctor (s) dilemma: ETV6-ABL1 positive acute lymphoblastic leukaemia, British journal of haematology, 2010 Journal Article, 2010

, Myelofibrosis, dose. reduced conditioning: the Irish experience, BONE MARROW TRANSPLANTATION, 2010 Journal Article, 2010

, Successful outcome of patients with relapsed/refractory Hodgkin's lymphoma treated with high dose therapy at a national adult bone marrow transplant unit, Dublin, Bone Marrow Transplantation, 2009 Journal Article, 2009

, Low incidence of factor viii inhibitor development in the dublin haemophilia A population following FVIII product switch: PP-MO-593, Journal of Thrombosis and Haemostasis, 2009 Journal Article, 2009

, Valproate activates phosphodiesterase-mediated cAMP degradation: relevance to C6 glioma G1 phase progression, Neurotoxicology and teratology, 2004 Journal Article, 2004

, Haemorrhagic infarction of the spleen in a patient with myelofibrosis, transforming to AML, European journal of haematology, 2004 Journal Article, 2004

, Automated in vitro screening of teratogens, Toxicology and applied pharmacology, 2002 Journal Article, 2002

, Fantini, Jacques, 209, Toxicology and Applied Pharmacology, 2002 Journal Article, 2002

, Antiproliferative action of valproate is associated with aberrant expression and nuclear translocation of cyclin D3 during the C6 glioma G1 phase, Journal of neurochemistry, 2002 Journal Article, 2002

, Modulation of cyclin protein expression during the C6 glioma G1 phase by the anticonvulsant valproate., BRITISH JOURNAL OF PHARMACOLOGY, 2001 Journal Article, 2001

, Antiproliferative actions of inhalational anesthetics: comparisons to the valproate teratogen, International Journal of Developmental Neuroscience, 2000 Journal Article, 2000

, Syntheses of benzoquinolizidine and benzoindolizidine derivatives as anti-amnesic agents, Bioorganic & medicinal chemistry, 1999 Journal Article, 1999

, Syntheses of 1, 2-diamino and 1, 2-aminoalcohol derivatives in the piperidine and pyrrolidine series as anti-amnesic agents, Bioorganic & medicinal chemistry, 1999 Journal Article, 1999

, IN VITRO SCREENING FOR TERATOGENIC POTENTIAL IN VOLATILE ANESTHETICS: A COMPARATIVE STUDY ON NOVEL AND ESTABLISHED AGENTS, Anesthesia & Analgesia, 1998 Journal Article, 1998

, Studies on the teratogen pharmacophore of valproic acid analogues: evidence of interactions at a hydrophobic centre, European journal of pharmacology, 1998 Journal Article, 1998

, Cell proliferation, migration and CAM-dependent neurite outgrowth as developmental in vitro endpoints for screening teratogenic potential: Application to valproic acid and related analogues of varying potency, Toxicology in vitro, 1998 Journal Article, 1998

, Correlation of in vitro anti-proliferative potential with in vivo teratogenicity in a series of valproate analogues (vol 15, pg 37, 1997), International Journal of Developmental Neuroscience, 1997 Journal Article, 1997

, Valproic acid suppresses G1 phase-dependent sialylation of a 65 kDa glycoprotein in the C6glioma cell cycle, International Journal of Developmental Neuroscience, 1997 Journal Article, 1997

, Correlation of in vitro anti-proliferative potential with in vivo teratogenicity in a series of valproate analogues, International journal of developmental neuroscience, 1997 Journal Article, 1997

, The contribution of the starter peptidases to flavour development in cheese, Proceedings of the 4th Cheese Symposium, Teagasc, University of Cork, Ireland, 1995 Journal Article, 1995

Research Expertise

Keywords

Chimerism and minimal residual disease in haematological malignancy; haematological malignancy

Recognition

Representations

Reviewer , British Journal of Haematology

Clinical Examiner for Royal college of physicians medical (MRCPI) examinations

Awards and Honours

Best Clinical Consultant Teacher Mater Hospital 2012

Journal of Medical Science Best Research Paper 2001

Class Prize Biochemistry (2nd Med) 1998

Class Prize Epidemiology and Public Health Medicine (3rd Med) 1999

Memberships

MRCPI 2004 – Present

FRCPath UK 2010 – Present

European Bone Marrow Transplant 2014 – Present

American society for Haematology 2015 – Current

Irish Haematology Society 2013 – Current

Haematology Association of Ireland 2012 – Current