Biography
I have added significantly to the field of genomic research, both within psychiatric genomics and the wider genomics community, through large multi-centre collaborations and by developing bioinformatics tools to improve our ability to study the effect of common and rare, protein-coding and regulatory variants (SuRFR (PMID:25400697) and PECAN (under review)). These studies have led to a greater understanding of the types of genetic variants segregating in families and their possible functional roles in susceptibility to psychiatric illness. My work has further underscored the lack of knowledge about the effects of genetic variants, and crucially, on the limitations of some of the commonly used sequencing technologies to fully describe the variation (PMID:37468985). I have extensive teaching experience and more than ten years PPI and science communication experience, including organising PPI events, scientific conferences and through my role as a member of the Outreach Committee for the Psychiatric Genomics Consortium (PGC) a global research initiative involving 900+ scientists.
Publications and Further Research Outputs
- Ormond C, Ryan NM, Corvin A, Heron EA., Converting single nucleotide variants between genome builds: from cautionary tale to solution., Briefings in bioinformatics, 2021Journal Article, 2021, DOI
- , Preliminary assessment of pre-morbid DNA methylation in individuals at high genetic risk of mood disorders., Bipolar disorders, 2016Journal Article, 2016, DOI
- , SuRFing the genomics wave: an R package for prioritising SNPs by functionality., Genome medicine, 2014Journal Article, 2014, DOI
- , Altered DNA methylation associated with a translocation linked to major mental illness., NPJ schizophrenia, 2018Journal Article, 2018, DOI
- , Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank., Translational psychiatry, 2017Journal Article, 2017, DOI
- , Identification of a novel locus on chromosome 2q13, which predisposes to clinical vertebral fractures independently of bone density., Annals of the rheumatic diseases, 2017Journal Article, 2017, DOI
- , Balanced translocation linked to psychiatric disorder, glutamate, and cortical structure/function., NPJ schizophrenia, 2016Journal Article, 2016, DOI
- Ormond C, Ryan NM, Byerley W, Heron EA, Corvin A, Investigating copy number variants in schizophrenia pedigrees using a new consensus pipeline called PECAN, Scientific Reports, 2024Journal Article, 2024, DOI
Research Expertise
Psychiatric genomics; pedigree studies, whole genome sequencing