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You are here Psychiatry > Research > Depression Neurobiology Research Group > Molecular

Molecular Psychiatry

Molecular Psychiatry looks at the biological mechanisms underlying psychiatric disorders and their treatment. The emphasis is on studies at the interface of pre-clinical and clinical research, including studies at the cellular, molecular, integrative, clinical, imaging and psychopharmacology levels.

Recent molecular psychiatry projects:

Gururajan A, Naughton ME, Scott KA, O'Connor RM, Moloney G, Clarke G, Dowling J, Walsh A, Ismail F, Shorten G, Scott L, McLoughlin DM, Cryan JF, Dinan TG. (2016) MicroRNAs as biomarkers for major depression: a role for let-7b and let-7c. Transl Psychiatry. Aug 2;6(8):e862. PMID: 27483380

Ryan KM, Kolshus E, McLoughlin DM (2016) MicroRNAs in Mood and Anxiety Disorders. Mapping of Nervous System Disease via MicroRNAs. Eds. Barbato C, Ruberti F. Series: Frontiers in Neurotherapeutics. Boca Raton, Fl, CRC Press, Taylor & Francis Group.

Gururajan A, Naughton ME, Scott KA, O'Connor RM, Moloney G, Clarke G, Dowling J, Walsh A, Ismail F, Shorten G, Scott L, McLoughlin DM, Cryan JF, Dinan TG. (2016) MicroRNAs as biomarkers for major depression: a role for let-7b and let-7c. Transl Psychiatry. Aug 2;6(8):e862. PMID: 27483380

O’Donovan SM, Dalton VS, Dunn MJ, McLoughlin DM (2015) The effects of chronic electroconvulsive stimulation on the rodent hippocampal proteome. Current Proteomics 12(4): 227-235.

Allen AP, Naughton M, Dowling J, Walsh A, Ismail F, Shorten G, Scott L, McLoughlin DM, Cryan JF, Dinan TG, Clarke G (2015) Serum BDNF as a peripheral biomarker of treatment-resistant depression and the rapid antidepressant response: a comparison of ketamine and ECT. J Affect Disord Nov; 186: 306-311. PMID: 26275358

O’Donovan SM, O’Mara S, Dunn MJ, McLoughlin DM (2014) The persisting effects of electroconvulsive stimulation on the hippocampal proteome. Brain Research 1593C: 106-116. PMID: 25451099

Glaviano A, O’Donovan SM, Ryan KM, O’Mara S, Dunn MJ, McLoughlin DM (2014) Acute phase plasma proteins are altered by electroconvulsive stimulation. J Psychopharmacol Dec;28(12):1125-34. PMID: 25271216

Kolshus E, Dalton VS, Ryan KM, McLoughlin DM (2014) When less is more - microRNAs and psychiatric disorders. Acta Psychiatrica Scand 129(4):241-56. PMID: 23952691

O’Donovan S, Dalton V, Harkin A, McLoughlin DM (2014) Effects of brief pulse and ultrabrief pulse electroconvulsive stimulation on rodent brain and behaviour in the corticosterone model of depression. Int J Neuropsychopharmacol 17(9):1477-86. PMID: 24607259

Dalton VS, Kolshus E, McLoughlin DM (2014) Epigenetics and depression: return of the repressed. J Affect Disord. Feb;155:1-12. PMID: 24238955

Ryan KM, O’ Donovan SM, McLoughlin DM (2013) Electroconvulsive stimulation alters levels of BDNF-associated microRNAs. Neurosci Lett; 549: 125-129. PMID: 23721784.

Hughes MM, Carballedo A, McLoughlin DM, Amico F, Harkin A, Frodl T, Connor TJ (2012) Tryptophan depletion in depressed patients occurs independent of kynurenine pathway activation. Brain Behav Immun. Aug;26(6):979-87. PMID: 22683764

O'Donovan S, Kennedy M, Guinan B, O'Mara S, McLoughlin DM (2012) A comparison of brief pulse and ultrabrief pulse electroconvulsive stimulation on rodent brain and behaviour. Prog Neuropsychopharmacol Biol Psychiatry 37(1): 147-152. PMID: 22230649

Frodl T, Carballedo A, Hughes MM, Saleh K, Fagan A, Skokauskas N, McLoughlin DM, Meaney J, O'Keane V, Connor TJ (2012) Reduced expression of glucocorticoid-inducible genes GILZ and SGK-1: high IL-6 levels are associated with reduced hippocampal volumes in major depressive disorder. Transl Psychiatry 2: e88; doi:10.1038/tp.2012.14. PMID: 22832853

Wassif WS, McLoughlin DM, Vincent RP, Conroy S, Russell GF, Taylor NF (2011) Steroid metabolism and excretion in severe anorexia nervosa: effects of refeeding. Am J Clin Nutr. 93(5):911-917. PMID: 23167953