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You are here Psychiatry > Research > Depression Neurobiology Research Group > Clinical Trials, Meta-analysis and Systematic Reviews

Evidence-Based Medicine

What is a systematic review?

systematic review answers a defined research question by collecting and summarising all empirical evidence that fits pre-specified eligibility criteria.

What is a meta-analysis?

meta-analysis is the use of statistical methods to summaries the results of these studies.


Recent systematic reviews and meta-analysis  

Erik Kolshus E, Jelovac A, Ryan KM, McLoughlin DM (2016) Bitemporal versus high-dose right unilateral electroconvulsive therapy for depression: a systematic review and meta-analysis of randomised controlled trials.
Psychol Med (in press).

Kolshus E, Dalton VS, Ryan KM, McLoughlin DM (2014)When less is more - microRNAs and psychiatric disorders. Acta Psychiatric Scand 129(4):241-56. PMID: 23952691

Dalton VS, Kolshus E, McLoughlin DM (2014) Epigenetics and depression: return of the repressed. J Affect Disord. Feb;155:1-12. PMID: 24238955

Jelovac A, Kolshus E, McLoughlin DM (2013) Relapse following successful electroconvulsive therapy for major depression: a meta-analysis. Neuropsychopharmacology; 38: 2467-2474.  PMID: 23774532.

Dunne RA, McLoughlin DM (2012) Systematic review and meta-analysis of bifrontal electroconvulsive therapy versus bilateral and unilateral electroconvulsive therapy in depression.  World J Biol Psychiatry 13(4): 248-258. PMID: 22098115

Semkovska M, Keane D, Babalola O, McLoughlin DM (2011). Unilateral brief-pulse electroconvulsive therapy and cognition: effects of electrode placement, stimulus dosage and time.  J Psychiatr Res 45: 770-780. PMID: 21109254

Semkovska M, McLoughlin DM (2010). Objective cognitive performance associated with electroconvulsive therapy for depression: a systematic review and meta-analysis. Biol Psychiatry 68(6):568-77. PMID: 20673880

For more information on eveidence based medicine, please follow this link for the CEBM (Centre for Evidence-Based Medicine)