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Professor Kumlesh Dev
Professor, Physiology
Professor, Trinity Inst. of Neurosciences (TCIN)

Publications and Further Research Outputs

Peer-Reviewed Publications

Béchet S, O'Sullivan SA, Yssel J, Fagan SG, Dev KK., Fingolimod Rescues Demyelination in a Mouse Model of Krabbe's Disease., Journal of Neuroscience, 40, 2020, p3104 - 3118 Journal Article, 2020 DOI

Velasco-Estevez M, Gadalla KKE, Liñan-Barba N, Cobb S, Dev KK, Sheridan GK., Inhibition of Piezo1 attenuates demyelination in the central nervous system., Glia, 68, 2020, p356 - 375 Journal Article, 2020 DOI

Velasco-Estevez M, Rolle SO, Mampay M, Dev KK, Sheridan GK., Piezo1 regulates calcium oscillations and cytokine release from astrocytes., Glia, 68, 2020, p145 - 160 Journal Article, 2020 DOI

Neyman S, Braunewell K-H, O'Connell KE, Dev KK, Manahan-Vaughan D, Inhibition of the Interaction Between Group I Metabotropic Glutamate Receptors and PDZ-Domain Proteins Prevents Hippocampal Long-Term Depression, but Not Long-Term Potentiation, Frontiers in Synaptic Neuroscience, 11, 2019, p13 Journal Article, 2019 TARA - Full Text DOI

Velasco-Estevez M, Mampay M, Boutin H, Chaney A, Warn P, Sharp A, Burgess E, Moeendarbary E, Dev KK, Sheridan GK., Infection Augments Expression of Mechanosensing Piezo1 Channels in Amyloid Plaque-Reactive Astrocytes., Front Aging Neurosci, 2018, p332- Journal Article, 2018 TARA - Full Text

O'Sullivan, S.A. and O'Sullivan, C. and Healy, L.M. and Dev, K.K. and Sheridan, G.K., Sphingosine 1-phosphate receptors regulate TLR4-induced CXCL5 release from astrocytes and microglia, Journal of Neurochemistry, 2018 Journal Article, 2018 TARA - Full Text DOI

Dutta, P. and Dargahi, L. and O'Connell, K.E. and Bolia, A. and Ozkan, B. and Sailer, A.W. and Dev, K.K., A novel modelling mechanism of PAEL receptor and GABARAPL2 interaction involved in Parkinson's disease, Neuroscience Letters, 673, 2018, p12-18 Journal Article, 2018 DOI

Rutkowska, A. and Shimshek, D.R. and Sailer, A.W. and Dev, K.K., EBI2 regulates pro-inflammatory signalling and cytokine release in astrocytes, Neuropharmacology, 133, 2018, p121-128 Journal Article, 2018 DOI TARA - Full Text

Rutkowska, A. and Sailer, A.W. and Dev, K.K., EBI2 receptor regulates myelin development and inhibits LPC-induced demyelination, Journal of Neuroinflammation, 14, (1), 2017, p250- Journal Article, 2017 DOI TARA - Full Text

Misslin, C. and Velasco-Estevez, M. and Albert, M. and O†Sullivan, S.A. and Dev, K.K., Phospholipase A2 is involved in galactosylsphingosine-induced astrocyte toxicity, neuronal damage and demyelination, PLoS ONE, 12, (11), 2017, e0187217- Journal Article, 2017 DOI TARA - Full Text

O'Sullivan S, Dev K.K, Sphingosine-1-phosphate receptor therapies: Advances in clinical trials for CNS-related diseases, Neuropharmacology, 113, 2017, p597 - 607 Journal Article, 2017 DOI URL

O'Sullivan S.A, Velasco-Estevez M, Dev K.K, Demyelination induced by oxidative stress is regulated by sphingosine 1-phosphate receptors, GLIA, 2017, p23148- Journal Article, 2017 URL DOI

O'Sullivan, S.A. and Dev, K.K., The chemokine fractalkine (CX3CL1) attenuates H2O2-induced demyelination in cerebellar slices, Journal of Neuroinflammation, 14, (1), 2017, p159- Journal Article, 2017 TARA - Full Text DOI

Dev K.K, Irving A.J, Lipid sensing G protein-coupled receptors in the CNS, Neuropharmacology, 113, 2017, p595 - 596 Journal Article, 2017 DOI URL

O'Sullivan C, Schubart A, Mir A.K, Dev K.K, The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures, Journal of Neuroinflammation, 13, (1), 2016, p31- Journal Article, 2016 DOI URL TARA - Full Text

Rutkowska A, O'Sullivan S.A, Christen I, Zhang J, Sailer A.W, Dev K.K, The EBI2 signalling pathway plays a role in cellular crosstalk between astrocytes and macrophages, Scientific Reports, 6, 2016, p25520 - Journal Article, 2016 DOI URL TARA - Full Text

O'Sullivan S.A, Gasparini F, Mir A.K, Dev K.K, Fractalkine shedding is mediated by p38 and the ADAM10 protease under pro-inflammatory conditions in human astrocytes, Journal of Neuroinflammation, 13, (1), 2016, p189- Journal Article, 2016 DOI TARA - Full Text URL

Dev K.K, Common receptor signalling in glial & immune cells, Current Drug Targets, 17, (16), 2016, p1828- Journal Article, 2016 URL

Madill M, Fitzgerald D, O'Connell K.E, Dev K.K, Shen S, FitzGerald U, In vitro and ex vivo models of multiple sclerosis, Drug Discovery Today, 21, (9), 2016, p1504 - 1511 Journal Article, 2016 DOI URL

O'Sullivan C, Dev K.K, Galactosylsphingosine (psychosine)-induced demyelination is attenuated by sphingosine 1-phosphate signalling, Journal of Cell Science, 128, (21), 2015, p3878 - 3887 Journal Article, 2015 DOI TARA - Full Text URL

Rutkowska, A. Preuss, I. Gessier, F. Sailer, A.W. Dev, K.K., EBI2 regulates intracellular signaling and migration in human astrocyte, Glia, 63, (2), 2015, p341 - 351 Journal Article, 2015 DOI URL

Muirhead, G. Dev, K.K., The expression of neuronal sorting nexin 8 (SNX8) exacerbates abnormal cholesterol levels, Journal of Molecular Neuroscience, 53, (1), 2014, p125 - 134 Journal Article, 2014 URL DOI

Shrestha, R., Millington, O., Brewer, J., Dev, K.K., Bushell, T.J., Lymphocyte-mediated neuroprotection in in vitro models of excitotoxicity involves astrocytic activation and the inhibition of MAP kinase signalling pathways, Neuropharmacology, 76, (a), 2014, p184-193 Journal Article, 2014 DOI

O'Connell, K.E. Mok, T. Sweeney, B. Ryan, A.M. Dev, K.K., The use of cytokine signature patterns: Separating drug naïve, interferon and natalizumab-treated multiple sclerosis patients, Autoimmunity, 47, (8), 2014, p505 - 511 Journal Article, 2014 URL DOI

Elain, G. Jeanneau, K. Rutkowska, A. Mir, A.K. Dev, K.K., The selective anti-IL17A monoclonal antibody secukinumab (AIN457) attenuates IL17A-induced levels of IL6 in human astrocytes, Glia, 62, (5), 2014, p725 - 735 Journal Article, 2014 URL DOI

Dutta, P., O'Connell, K.E., Ozkan, S.B., Sailer, A.W., Dev, K.K., The protein interacting with C-kinase (PICK1) interacts with and attenuates parkin-associated endothelial-like (PAEL) receptor-mediated cell deat, Journal of Neurochemistry, 130, (3), 2014, p360-373 Journal Article, 2014 TARA - Full Text DOI

David O, Mattes H, Joachim N, Dev KK., 'BENZAMIDAS UTILIZÁVEIS COMI MODULADORES DO RECEPTOR DE S1P. ', Dannemann, Siemsen, Bigler & Ipanema Moreira., BR/PI0811932, 2014 Patent, 2014 Other

David O, Mattes H, Joachim N, Dev KK., 'DERIVADOS DE FTALAZINA E ISOQUINOLINA COM ATIVIDADES MODULADORAS DO RECEPTOR DE S1P.', Dannemann, Siemsen, Bigler & Ipanema Moreira., BR/PI0810123, 2014 Patent, 2014 Other

O'Connell, K.E. Thakore, J. Dev, K.K., Increased interleukin 23 (IL23) levels in schizophrenia patients treated with depot antipsychotic medication, Cytokine, 73, (1), 2014, p196-198 Journal Article, 2014 URL DOI

O'Connell, K.E., Frei, P. , Dev, K.K., The premium of a big pharma license deal, Nature Biotechnology, 32, (7), 2014, p617-619 Journal Article, 2014 DOI

Pritchard, AJ, Mir, AK, Dev, KK, Fingolimod Attenuates Splenocyte-Induced Demyelination in Cerebellar Slice Cultures, PLOS ONE, 9, (6), 2014, p0099444- Journal Article, 2014 TARA - Full Text DOI

Sheridan, GK, Dev, KK, Targeting S1P receptors in experimental autoimmune encephalomyelitis in mice improves early deficits in locomotor activity and increases ultrasonic vocalisations, SCIENTIFIC REPORTS, 4, 2014, p5051- Journal Article, 2014 TARA - Full Text DOI

O'Connell, KE, Thakore, J, Dev, KK, Pro-inflammatory cytokine levels are raised in female schizophrenia patients treated with clozapine, SCHIZOPHRENIA RESEARCH, 156, (1), 2014, p1-8 Journal Article, 2014 DOI

Frei, P., Dev, K.K., Drug dealers: $20 trillion of in-licensing payments (Editorial), Drug Discovery Today, 18, (21-22), 2014, p1027-1029 Journal Article, 2014 DOI

Pritchard, A.J., Dev, K.K. , The role of sphingosine 1-phosphate receptors in the treatment of demyelinating diseases (Review), Future Neurology, 8, (5), 2013, p569-581 Journal Article, 2013 DOI

O'Sullivan, C., Dev, K.K. , The structure and function of the S1P1 receptor (Review), Trends in Pharmacological Sciences, 34, (7), 2013, p401-412 Journal Article, 2013 DOI

Doucet MV, Levine H, Dev KK, Harkin A, Small-Molecule Inhibitors at the PSD-95/nNOS Interface have Antidepressant-Like Properties in Mice., Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 38, (8), 2013, p1575-1584 Journal Article, 2013 DOI TARA - Full Text

Healy LM, Sheridan GK, Pritchard AJ, Rutkowska A, Mullershausen F, Dev KK, Pathway specific modulation of S1P1 receptor signalling in rat and human astrocytes., British journal of pharmacology, 169, (5), 2013, p1114-1129 Journal Article, 2013 DOI TARA - Full Text

O'Connell K, Thakore J, Dev KK, Levels of S100B are raised in female patients with schizophrenia., BMC psychiatry, 13, 2013, p146 Journal Article, 2013 TARA - Full Text DOI

Sheridan GK, Dev KK, S1P1 receptor subtype inhibits demyelination and regulates chemokine release in cerebellar slice cultures., Glia, 60, (3), 2012, p382-92 Journal Article, 2012

Bolia A, Gerek ZN, Keskin O, Banu Ozkan S, Dev KK, The binding affinities of proteins interacting with the PDZ domain of PICK1., Proteins, 80, (5), 2012, p1393-408 Journal Article, 2012

Mattes H, Joachim N, David O, Dev KK. , 'BENZAMIDES USEFUL AS S1P RECEPTOR MODULATORS. Novartis Pharma AG Patent Department. ', Novartis AG Corporate Intellectual Property, IN7219/DELNP/2009, 2012 Patent, 2012 Other

Doucet MV, Harkin A, Dev KK, The PSD-95/nNOS Complex: New Drugs for Depression?, Pharmacology & Therapeutics, 133, 2012, p218 - 229 Journal Article, 2012 TARA - Full Text

Doucet MV, Harkin A, Dev KK, The PSD-95/nNOS complex: New drugs for depression?, Pharmacology and Therapeutics, 133, (2), 2012, p218-29 Journal Article, 2012 DOI

Claus Rieker, Kumlesh K. Dev, Katja Lehnhoff, Samuel Barbieri, Iwona Ksiazek, Sabine Kauffmann, Simone Danner, Heinrich Schell, Cindy Boden, Markus A. Ruegg, Philipp J. Kahle, Herman van der Putten, Derya R. Shimshek, Neuropathology in Mice Expressing Mouse Alpha-Synuclein, PLoS ONE, 6, (9, e24834), 2011 Journal Article, 2011 TARA - Full Text

Mattes H, Joachim N, David O, Dev KK. , 'BENZAMIDES USEFUL AS S1P RECEPTOR MODULATORS. Novartis Pharma AG Patent Department. ', Novartis Institutes for Biomedical Research Inc, US/2010/0197753, 2010 Patent, 2010 Other

Mattes H, Joachim N, David O, Dev KK. , 'HTHALAZINE AND ISOQUINOLINE DERIVATIVES WITH SLP RECEPTOR MODULATING AVTIVITIES', Novartis AG Corporate Intellectual Property, IN/6695/DELNP/2009, 2010 Patent, 2010 Other

Mattes H, Joachim N, David O, Dev KK. , 'PHTHALAZINE AND ISOQUINOLINE DERIVATIVES WITH SLP RECEPTOR MODULATING ACTIVITIES.', Novartis AG Corporate Intellectual Property, EP/2148863, 2010 Patent, 2010 Other

Mattes H, Joachim N, David O, Dev KK. , 'PHTHALAZINE AND ISOQUINOLINE DERIVATIVES WITH SLP RECEPTOR MODULATING ACTIVITIES.', Huang Gesheng Lin Bainan, CN/101679274, 2010 Patent, 2010 Other

H. Mattes, K.K. Dev, R. Bouhelal, C. Barske, F. Gasparini, D. Guerini, A.K. Mir, D. Orain, M. Osinde, A. Picard, C. Dubois, E. Tasdelen, S. Haessig. , Design and synthesis of selective and potent orally active S1P5 agonists., Chem Med Chem , 5, 2010, p1693 - 1696 Journal Article, 2010 TARA - Full Text

David O, Joachim N, Mattes H, Dev KK, 'BENZAMIDES USEFUL AS S1P RECEPTOR MODULATORS. Novartis Pharma AG Patent Department. ', Huang Gesheng Lin Bainan, CN/101687774, 2010 Patent, 2010 Other

Mattes H, Joachim N, David O, Dev KK. , 'BENZAMIDES USEFUL AS S1P RECEPTOR MODULATORS. Novartis Pharma AG Patent Department. ', Novartis Pharma AG Patent Department, EP2162427, 2010 Patent, 2010 Other

Joachim N, Mattes H, David O, Dev KK. , 'PHTHALAZINE AND ISOQUINOLINE DERIVATIVES WITH SLP RECEPTOR MODULATING ACTIVITIES.', CESAR RAMOS DE MIGUEL, MXMX/A/2009/011421, 2010 Patent, 2010 Other

Mattes H, Joachim N, David O, Dev KK. , 'BICYCLIC S1P RECEPTOR MODULATORS.', Novartis Institutes for Biomedical Research Inc, US2010/0179153, 2010 Patent, 2010 Other

P. Dutta, D. Deb, L. Dargahi, D. Ivankovic, K.K. Dev, The GPR37/PAEL Receptor - Finding a Way to the Cell Surface., Drug Discovery , 7, 2010, p36 - 39 Journal Article, 2010

S. Chatterjee, J.D. Szustakowski, N.R. Nanguneri, C. Mickanin, M.A. Labow, A. Nohturfft, K.K. Dev* and R. Sivasankaran. , Identification of Novel Genes and Pathways Regulating SREBP Transcriptional Activity. , PLoS ONE , 4, 2009, p5197- Journal Article, 2009 TARA - Full Text

Dev KK, Mattes H, Joachim N, David O., 'BENZAMIDES USEFUL AS S1P RECEPTOR MODULATORS. Novartis Pharma AG Patent Department. ', Davies Collison Cave Pty Ltd, AU/2008/252943, 2009 Patent, 2009 Other

Chatterjee S, Dev KK, Kuhn RR, Sivasankaran R. , 'GENES REGULATING INTRACELLULAR CHOLESTEROL TRAFFICKING AS TARGETS FOR TREATMENT OF CHOLESTEROL-RELATED DISEASES.', Novartis Pharma AG Patent Department. , EP2032599, 2009 Patent, 2009 Other

Dev KK, Mattes H, Joachim N, David O. , 'PHTHALAZINE AND ISOQUINOLINE DERIVATIVES WITH SLP RECEPTOR MODULATING ACTIVITIES.', Davies Collison Cave Pty Ltd, AU/2008/240679, 2009 Patent, 2009 Other

Senechal Y, Kelly PH, Dev KK, Amyloid precursor protein knockout mice show age-dependent deficits in passive avoidance learning., Behavioural brain research, 186, (1), 2008, p126-32 Journal Article, 2008

Mattes H, Joachim N, David O, Dev KK. , 'BENZAMIDES USEFUL AS S1P RECEPTOR MODULATORS. Novartis Pharma AG Patent Department. ', Novartis Pharma AG Patent Department, WO/2008/142073, 2008 Patent, 2008 Other

Mattes H, Joachim N, David O, Dev KK. , 'PHTHALAZINE AND ISOQUINOLINE DERIVATIVES WITH S1P RECEPTOR MODULATING ACTIVITIES', Novartis AG Corporate Intellectual Property, CA/2684965, 2008 Patent, 2008 Other

Mattes H, Joachim N, David O, Dev KK. , 'BENZAMIDES USEFUL AS S1P RECEPTOR MODULATORS. Novartis Pharma AG Patent Department. ', Novartis AG Corporate Intellectual Property, CA/2686953, 2008 Patent, 2008 Other

Senechal Y, Prut L, Kelly PH, Staufenbiel M, Natt F, Hoyer D, Wiessner C, Dev KK, Increased exploratory activity of APP23 mice in a novel environment is reversed by siRNA., Brain research, 1243, 2008, p124-33 Journal Article, 2008

Mattes H, Joachim N, David O, Dev KK. , 'PHTHALAZINE AND ISOQUINOLINE DERIVATIVES WITH SLP RECEPTOR MODULATING ACTIVITIES. ', Novartis Pharma AG Patent Department, WO/2008/129029, 2008 Patent, 2008 Other

Osinde M, Clavaguera F, May-Nass R, Tolnay M, Dev KK, Lentivirus Tau (P301S) expression in adult amyloid precursor protein (APP)-transgenic mice leads to tangle formation., Neuropathology and applied neurobiology, 34, (5), 2008, p523-31 Journal Article, 2008

Olson BL, Hock MB, Ekholm-Reed S, Wohlschlegel JA, Dev KK, Kralli A, Reed SI, SCFCdc4 acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis., Genes & development, 22, (2), 2008, p252-64 Journal Article, 2008 DOI TARA - Full Text

K.K. Dev, F. Mullershausen, H. Mattes, R. Kuhn, G. Bilbe, D. Hoyer, A. Mir, Brain S1P receptors: implication for fingolimod in the treatment of multiple sclerosis., Pharmacology & Therapeutics , 117, 2008, p77 - 93 Journal Article, 2008

M. Osinde, F. Mullershausen and K.K. Dev. , Phosphorylated FTY720 stimulates ERK phosphorylation in Astrocytes via S1P receptors. Neuropharmacology, 52, 2007, p1210 - 1218 Journal Article, 2007

J.F. Cryan and K.K. Dev, The Glutamatergic System as a Potential Therapeutic Target for the Treatment of Anxiety Disorders, PUBLISHED BOOK Handbook of Anxiety and Fear, Elsevier, Academic Press , 17, 2007, p269 - 301 Journal Article, 2007

F. Mullershausen, L.M. Craveiro, Y. Shin, M. Cortes-Cros, F. Bassilana, M. Osinde, W.L. Wishart, D. Guerini, M. Thallmair, M.E. Schwab, R. Sivasankaran, K. Seuwen and K.K. Dev. , Phosphorylated FTY720 promotes astrocyte migration through sphingosine-1-phosphate receptors., J. Neurochemistry , 102, 2007, p1151 - 1161 Journal Article, 2007

Chatterjee S, Dev KK, Kuhn RR, Sivasankaran R, 'GENES REGULATING INTRACELLULAR CHOLESTEROL TRAFFICKING AS TARGETS FOR TREATMENT OF CHOLESTEROL-RELATED DISEASES', Novartis AG Corporate Intellectual Property, WO/2007/141346, 2007 Patent, 2007 Other

Y. Senechal, P.H. Kelly, J.F. Cryan, F. Natt, and K.K Dev., Amyloid precursor protein knockdown by siRNA impairs spontaneous alternation in adult mice. , J. Neurochemistry , 102, 2007, p1928 - 1940 Journal Article, 2007 TARA - Full Text

K.K. Dev, PDZ domain protein-protein interactions: a case study with PICK1, Current Topics in Medicinal Chemistry , 7, 2007, p3 - 20 Journal Article, 2007

K.K. Dev, Using RNAi in the Clinic, Investigational Drugs Journal , 9, 2006, p279 - 282 Journal Article, 2006

K.K. Dev, S. Chatterjee, M. Osinde, D. Stauffer, H. Morgan, M. Kobialko, U. Dengler, H. Rueeger, B. Martoglio and G. Rovelli, Signal peptide peptidase dependent cleavage of type II transmembrane substrates releases intracellular and extracellular signals, Eur. J. Pharmacology , 540, 2006, p10 - 17 Journal Article, 2006

Y. Senechal, Y. Larmet and K.K. Dev, Unraveling in vivo functions of Amyloid Precursor Protein: insights from knockout and knockdown studies, Neurodegenerative Diseases , 3, 2006, p134 - 147 Journal Article, 2006

D. Hoyer and K. K. Dev, RNA interference as a therapeutic strategy for treating CNS disorders, Drug Discovery Today Therapeutic Strategies, 3, 2006, p451 - 456 Journal Article, 2006

K.K. Dev and J.M. Henley, The Schizophrenic Faces of PICK1, Trends Pharmacol Sci , 27, 2006, p574 - 579 Journal Article, 2006 DOI TARA - Full Text

C. Mahé, E. Loetscher, K.K. Dev, I. Bobirnac, U. Otten and P. Schoeffter., Serotonin 5-HT7 receptors coupled to induction of interleukin-6 in human microglial MC-3 cells, Neuropharmacology, 49, 2005, p40 - 47 Journal Article, 2005

K.L. Madsen, T. Beuming, M.Y. Niv, C-W. Chang, K.K. Dev, H. Weinstein and U. Gether, Delineating the complex PDZ domain binding specificity of PICK1, J. Biol Chem , 280, 2005, p20539 - 20548 Journal Article, 2005

K.K. Dev, S. Nakanishi and J.M. Henley, The PDZ domain of PICK1 differentially accepts Protein Kinase C-á and GluR2 as interacting ligands, J. Biol Chem , 279, 2004, p41393 - 41397 Journal Article, 2004 TARA - Full Text

E. Friedmann, M.K. Lemberg, A. Weihofen, K.K. Dev, U. Dengler, G. Rovelli and B. Martoglio, Consensus analysis of Signal Peptide Peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared to Presenilins, J. Biol Chem , 279, 2004, p50790 - 50798 Journal Article, 2004 TARA - Full Text

C. Mahé, M. Bernhard, I. Bobirnac, C. Keser, E. Loetscher, D. Feuerbach, K.K. Dev and P. Schoeffter, Functional expression of serotonin 5-HT7 receptor in human glioblastoma cell lines, Br. J. Pharmacolology, 143, 2004, p404 - 410 Journal Article, 2004 TARA - Full Text

A. Terashima, L. Cotton, K.K. Dev, G. Meyer, S. Zaman, F. Duprat, J.M. Henley, G.L. Collingridge and J.T.R. Isaac, Regulation of synaptic strength & AMPA receptor subunit composition by PICK1, J. Neuroscience , 24, 2004, p5381 - 5390 Journal Article, 2004 TARA - Full Text

K.K. Dev, Making protein interactions druggable: targeting PDZ domains, Nature Reviews Drug Discovery , 3, 2004, p1047 - 1056 Journal Article, 2004

K.K. Dev, K. Hofele, S. Barbieri, V. Buchman and H. van der Putten. , Part II: á-Synuclein and its molecular pathophysiological role in neurodegenerative disease, Neuropharmacology, 45, 2003, p14 - 44 Journal Article, 2003

N. Finney, F. Walther, P-Y. Mantel, D. Stauffer, G. Rovelli and K.K. Dev., The cellular protein level of Parkin is regulated by its ubiquitin-like domain, J. Biol Chem, 278, 2003, p16054 - 16058 Journal Article, 2003 TARA - Full Text

K. Cho, J. Francis, H. Hirbec, K. Dev, M. Brown, J. Henley, and Z. I. Bashir, Regulation of kainate receptors by protein kinase C and metabotropic glutamate receptors, J. Physiology , 548, 2003, p723 - 730 Journal Article, 2003

K.K. Dev, H. van der Putten, B. Sommer and G. Rovelli, Part I: Parkin-associated proteins and Parkinson's Disease, Neuropharmacology, 45, 2003, p1 - 13 Journal Article, 2003

H. Hirbec, J.C. Francis, S.E. Lauri, S.P. Braithwaite, F. Coussen, C. Mulle, K.K. Dev, V. Couthino, G. Meyer, J.T.R. Isaac, G.L. Collingridge and J.M. Henley, Rapid and differential regulation of AMPA and kainite receptors at hippocampal mossy fibre synapses by PICK1 and GRIP, Neuron , 37, 2003, p625 - 638 Journal Article, 2003 TARA - Full Text

H. Hirbec, O. Perestenko, A. Nishimune, G. Meyer, S. Nakanishi, J.M. Henley, and K.K. Dev, The PDZ Proteins PICK1, GRIP and Syntenin bind multiple glutamate receptor subtypes, J. Biol Chem , 277, 2002, p15221 - 15224 Journal Article, 2002 TARA - Full Text

E. Vernon, G. Meyer, L. Pickard, K. Dev, E. Molnar, G.L. Collingridge and J.M. Henley, GABAB receptors couple directly to the transcription factor ATF4, Molecular Cell Neuroscience , 17, 2001, p637 - 645 Journal Article, 2001

K.K. Dev, S. Nakanishi and J. M. Henley, Regulation of mGlu7 receptors by proteins that interact with the intracellular C-terminus, Trends Pharmacol Sci , 22, 2001, p355 - 361 Journal Article, 2001

K.K. Dev, Y. Nakajima, J. Kitano, S. P. Braithwaite, J. M. Henley and S. Nakanishi, PICK1 interacts with and regulates PKC phosphorylation of mGluR7, J. Neuroscience , 20, 2000, p7252 - 7257 Journal Article, 2000

M.I. Daw, R. Chittajallu, Z.A. Bortolotto, K.K. Dev, F. Duprat, J.M. Henley, G.L. Collingridge and J.T.R. Isaac, PDZ Proteins interacting with c-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses, Neuron , 28, 2000, p873 - 886 Journal Article, 2000 TARA - Full Text

M.J. Keir, M.J. Barakat, K.K. Dev, H. Bittiger, B. Bettler and J.M. Henley, Characterisation of GABAB receptor from rat cerebellum using novel antagonist [3H]CGP 62349, Molecular Brain Research , 71, 1999, p279 - 289 Journal Article, 1999

K.K. Dev, A. Nishimune, J.M. Henley and S. Nakanishi, The protein kinase Cá binding protein PICK1 interacts with short but not long form alternative splice variants of AMPA receptor subunits, Neuropharmacology, 38, 1999, p635 - 644 Journal Article, 1999

K.K. Dev, T. Honoré and J.M. Henley, Different effects of Phospholipase A2 on agonist binding to hippocampal, cortical and recombinant homomeric AMPA receptors, Neuroscience Letters , 246, 1998, p25 - 28 Journal Article, 1998

K.K. Dev and J.M. Henley, The Regulation of AMPA receptor binding sites, Molecular Neurobiology , 17, 1998, p33 - 58 Journal Article, 1998

K.K. Dev, C. Foged, H. Andersen, T. Honoré and J.M. Henley, High affinity binding sites for [125I]-labelled pancreatic secretory phospholipase A2 in rat brain, Molecular Brain Research , 49, 1997, p120 - 126 Journal Article, 1997

K.K. Dev, P.J. Roberts, and J.M. Henley, Characterisation of the interaction between guanyl nucleotides and AMPA receptors in rat brain, Neuropharmacology, 35, 1996, p1583 - 1593 Journal Article, 1996

R. Chittajallu, M. Vignes, K.K. Dev, J.M. Barnes, G.L. Collingridge and J.M. Henley, Regulation of glutamate release by presynaptic kainate receptors in the hippocampus, Nature, 379, 1996, p78 - 81 Journal Article, 1996

K.K. Dev, V. Petersen, T. Honoré and J.M. Henley, Pharmacology and regional distribution of [3H] 6-nitro-7-sulphamoylbenzo(F)quinoxaline-2-3 dione ([3H]NBQX) binding to rat brain, J. Neurochemistry , 67, 1996, p2609 - 2612 Journal Article, 1996

K.K. Dev, T. Honoré and J.M. Henley, Phospholipase A2 down-regulates the affinity of [3H]AMPA binding to rat cortical membranes, J. Neurochemistry , 65, 1995, p184 - 191 Journal Article, 1995

Barnes JM, Dev KK and Henley JM, Cyclothiazide unmasks AMPA-evoked stimulation of [3H]-L-glutamate release from rat hippocampal synaptosomes, Br. J. Pharmacology , 113, 1994, p339 - 341 Journal Article, 1994 TARA - Full Text

Dev KK and Morris BJ, Modulation of a-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) binding sites by nitric oxide, Journal of Neurochemistry , 63, 1994, p946 - 952 Journal Article, 1994

Non-Peer-Reviewed Publications

Dev KK, 6th Annual Meeting. Frontiers in Neurology Ireland (FIN), Irish J Med. Sci., 186, 2017, p281 - 298 Journal Article, 2017

Dev KK, 5th Annual Meeting. Frontiers in Neurology Ireland (FIN), Irish J Med. Sci., 185, 2016, p169 - 185 Journal Article, 2016

Dev KK, Neurology, Professor Kumlesh Dev sets out Ireland's position on brain disease. Irish Independent (Supplement), 2015, - Miscellaneous, 2015

Dev KK, 4th Annual Meeting. Frontiers in Neurology Ireland (FIN), Irish J Med. Sci., 184, 2015, p1 - 18 Journal Article, 2015

Dev KK, 3rd Annual Meeting. Frontiers in Neurology Ireland (FIN), Irish J Med. Sci. , 183, 2014, p71 - 85 Journal Article, 2014

Dev KK, 2nd Annual Meeting. Block MS Ireland. Neuroprotection: At the cellular, in vivo and clinical level., Irish J Med. Sci., 182, 2013, p1 - 13 Journal Article, 2013

Research Expertise

Description

My research interests lie within the area of neurosciences and drug development. This research investigates the biology of brain cells, to understand their abnormal function in disease with a view to developing new targeted therapies for brain disorders. In particular, my research focusses on brain glial cells, called astrocytes and oligodendrocytes. The purpose of these studies is to gain knowledge in glial cell biology, identify new molecular drug targets, and develop novel therapies to treat brain diseases. The research studies cellular mechanisms of disease by combining fields of molecular biology, cell science, biochemistry, pharmacology and medicine. We work integrates and collaborates within the areas of biology, medicine, engineering, pharmaceutical industry, entrepreneurship, and commercialisation to ultimately deliver medicines to market. My expertise in drug development is significant and I have a wide range of collaborative networks globally within academia and industry. I have provided leadership to large research projects within pharmaceutical industry, that have led to the successful development of follow-on compounds of the marketed drug Gilenya, the first oral therapy for multiple sclerosis. My research group was the first to demonstrate that Gilenya directly regulates brain cells. This work has been unique and substantive, it has transformed our understanding in the field, and most importantly has been fundamental to the development new strategies for making follow-on drugs. I currently lead the Drug Development group at Trinity, which investigates mechanisms underlying demyelinating disorders, as well as neuro-inflammatory and neurodegenerative diseases. We have primarily focussed on diseases such as multiple sclerosis, Alzheimer's Disease, Parkinson's Disease and Niemann Pick Disease Type C, and more recently investigating the rare paediatric demyelinating disorder, Krabbes disease. The research activities of my group draw upon close collaborations in the academic, medical and industrial arenas, both nationally and internationally. This research has provided a method for continued research funding and dissemination success, excellence and impact. The research is well supported by highly competitive national and international funding agencies as well as multinational pharmaceutical industry. The research has been funded in kind and in part by Trinity College Dublin, Science Foundation Ireland, Health Research Board Ireland, Enterprise Ireland, The Wellcome Trust and industry including Lundbeck, Actelion, Servier and Novartis. With several years of experience in the area of demyelinating diseases, I have published extensively on glial cell biology and processes of myelination. My research group has shown that development compounds and marketed drugs can rescue toxin-induced glia cell death, reactivity and demyelination as well as damage of neurons. My research has demonstrated methods that can increase the lifespan of twitcher mice, an animal mouse model of Krabbes disease. All of these findings have been published in high quality journals and are the subject of international recognition. My research has been continued and sustained, moving from cellular experiments to animal disease model studies and paving the way for clinical development. Altogether, these activities are transformational in nature and based on a global reputation in the area of glial cell biology and drug development. Having developed research and infrastructure that integrates in vitro, ex vivo and in vivo approaches to study mechanisms of brain diseases, my vision for the future, over the next 5 years, is to build a research programme that integrates neuroscience and drug development within Trinity. The aim is to provide a research platform that allows for the generation of novel intellectual property, which can be exploited for out-licencing activities and/or be developed toward market.

Keywords

DEMYELINATION; Drug development; Glial biology; Neuroscience

Recognition

Representations

External Examiner, MSc Clinical Neuroscience, NUI Galway, Ireland 2020-Current

Visiting Professor, Dept. Food & Drug Sciences, University of Parma, Italy 2020-Current

Fellow, Trinity College Dublin (FTCD) 2014-Current

President, Frontiers in Neurology Ireland (FIN) 2011-2017

Council Member, Society for Neuroscience Ireland 2013-2015

Council Member, Swiss Tissue Culture Society 2005-2006

Member, Society for Neuroscience 2000-Current

Editorial Board Member, Int J. Mol. Sci (Molecular Neurobiology) (invited) 2020-Current

Editorial Board Member, Brain, Behavior, and Immunity 2016-Current

Editorial Board Member, Scientific Reports 2014-Current

Editorial Board Member, Canadian Journal of Pure and Applied Sciences 2012-2014

Editorial Board Member, Journal of Biological Chemistry 2005-2011

Awards and Honours

Fellow Trinity College Dublin (FTCD) 2014

Memberships

External Examiner, MSc Clinical Neuroscience, NUI Galway, Ireland 2020 – Current

Visiting Professor, Dept. Food & Drug Sciences, University of Parma, Italy 2020 – Current

Fellow, Trinity College Dublin (FTCD) 2014 – Current

President, Frontiers in Neurology Ireland (FIN) 2011 – 2017

Council Member, Society for Neuroscience Ireland 2013 – 2015

Council Member, Swiss Tissue Culture Society 2005 – 2006

Member, Society for Neuroscience 2000 – Current

Editorial Board Member, Int J. Mol. Sci (Molecular Neurobiology) (invited) 2020 – Current

Editorial Board Member, Brain, Behavior, and Immunity 2016 – Current

Editorial Board Member, Scientific Reports 2014 – Current

Editorial Board Member, Canadian Journal of Pure and Applied Sciences 2012 – 2014

Editorial Board Member, Journal of Biological Chemistry 2005 – 2011