General Paediatrics and Complex Needs
Staff
| Coghlan | David | Dr | Community and General Paediatrician |
| Manning | Rosemarie | Dr | General Paediatric Consultant |
| McGrane | Fiona | Research Nurse in Down Syndrome | |
| O'Mullane | Elaine | Clinical Lecturer in Paediatrics |
Dr. David Coghlan
Clinical Associate Professor, Paediatrics
Clinical Associate Professor, School Office - Medicine
Publications and Further Research Outputs
Peer-Reviewed Publications
Coghlan D, Priorities for child health research across the UK and Ireland. , Archives ofr Disease in Childhood, 107, (5), 2022, p474 - 478
Byrne AM, Trujillo J, Fitzsimons j... Coghlan D., Mass food challenges in a vacant COVID-19 stepdown facility: Exceptional opportunity provides a model for the future, Pediatr Allergy Immunol. 2021, 2021
Coghlan D, Management of anaphylaxis in children undergoing oral food challenges in an adapted COVID-19 field hospital, Archives of Disease in Childhood, 2021
D. Coghlan, U. Murtagh, M. Nadeem, Integration of Two Acute Paediatric Services During COVID-19, Ir Med J, 114, (4), 2021, p324
Coghlan D, What does 'PEWing' or 'PEWsing' mean? A new word in paediatrics. Diskin C, MacDonell R, Whelan B, O' Shea O, Fitzsimons JJ, Vaughan D, Coghlan D. Arch Dis Child. 2020 May;105(5):518-519. doi: 10.1136/archdischild-2019-318252. Epub 2019 Nov 20, Achives of Disease in Childhood, (105(5):), 2020, p518 - 519
C Howard, WL Macken, A Connolly, M Keegan, D Coghlan, DW Webb, Percutaneous endoscopic gastrostomy for refractory epilepsy and medication refusal, Arch Dis Child, 2019
N Gadelsayed, D Coghlan, Case series of herpes simplex virus meningoencephalitis in a single paediatric centre over a 10-year period , Joint IPA/Welsh Paediatric Society , 2018, 2018
Hutchinson K, Kerley CP, Faul J, Greally P, Coghlan D, Louw M, Elnazir B, Rochev Y. , Vitamin D receptor variants and uncontrolled asthma , Eur Ann Allergy Clin Immunol. 2018 , 2018
Kerley CP, Elnazir B, Greally P, Coghlan D. , Blunted serum 25(OH)D response to vitamin D3 supplementation in children with autism, Nutr Neurosci. , 2018
N Gadelsayed, D Coghlan, Influenza in children; is there a pattern of adverse outcomes and are inflammatory markers predictive?, Joint Irish Paediatric Association/Welsh Paediatric Society Meeting 2018, 2018
Kenosi M, Whitla L, Khan N, Carty E, Coghlan D, Nadeem M, Interpretation of pyuria in children with urinary tract infection , Acta paediatrica (Oslo, Norway : 1992) , 107, (2), 2018, p358-
Rutledge E, Whitla L, Coghlan D, Nadeem M, Peripheral White Blood Cell Differential Counts In Children With UTI, Is There A Link?, Irish Medical Journal, 111, (6), 2018
Khan N, Whitla L, Kenosi M, Coghlan D, Nadeem M, Follow up chest radiography in paediatric pneumonia: is it avoidable? , Irish Medical Journal, 2018
N Khan, D Coghlan, N Gadelsayed, Follow Up Chest Radiography in Paediatric Pneumonia: Is It Avoidable? , IPA, 2017
E Carty, D Coghlan, N Gadelsayed, Interpretation of pyuria in children with urinary tract infection, IPA, 2017
M Alsaffar, N Gadelsayed, D Coghlan, Molloy E, Prevalence of Coeliac Disease in Children with Down syndrome, Archives of Disease in Childhood 2017;102:A106., Pediatric Academic Societies (PAS) 2017 Meeting, May 6 - 9, in San Francisco, CA.Meeting Abstract, San Francisco, 2017, 102, 2017
S Neville, N Gadelsayed, D Coghlan, Working to implement guidelines for UTI assessment and management: the "Wiguam" quality improvement initiative , Irish Paediatric Association , 2017, 2017
Macken WL, Clarke N, Nadeem M, Coghlan D, Life After the Event: A Review of Basic Life Support Training for Parents Following Apparent Life-Threatening Events and Their Experience and Practices Following Discharge , Irish Medical Journal, 110 , (5 ), 2017, p572 - 574
Kerley CP, Power C, Gallagher L, Coghlan D , Lack of effect of vitamin D3 supplementation in autism: a 20-week, placebo-controlled RCT, Arch Dis Child 2017 , 2017
Reynolds A, O'Driscoll J, Quinn S, Coghlan D. , Cows Milk Allergy: A Cohort of Patients from a University Hospital, Ir Med J. , 2016
S Tamgumus, J Geoghegan, D Coghlan, M Nadeem. , Urinary tract infection in childhood and inflammatory markers , IPA, 2016
Kerley CP, Hutchinson K, Cormican L, Faul J, Greally P, Coghlan D, Elnazir B, Vitamin D3 for uncontrolled childhood asthma: a pilot study, Pediatric Allergy and Immunology 27 (4), 404-412 , 2016
Tamgumus S, Geoghan J, Coghlan D, Nadeem M, Urinary Tract Infection in Childhood and Inflammatory Markers, Irish Medical Journal, 109 , (7 ), 2016, p442 -
Murphy K, Scanlan B, Coghlan D, Does this child really have a penicillin allergy?, Ir Med J, 2015
CP Kerley, K Hutchinson, P Greally, D Coghlan, B Elnazir , A randomized, double-blind, placebo-controlled of Vitamin D3 for Irish children with asthma , Nutrition Society, 2015
WL Macken, D Coghlan, N Montasseur, An audit of basic life support training for parents following apparent life threatening events (ALTE) in early childhood., IPA, 2015, 2015
CP Kerley, K Hutchinson, P Greally, D Coghlan, B Elnazir , The Effects of Vitamin D Supplementation on Pulmonary Function, Disease Severity and Markers of Inflammation in Childhood Asthmatics: A Randomized, Double-Blind, Placebo , IPA, 2014
Cunningham K, Scanlan B, Coghlan D, Quinn S, Infants with FPIES to solid food proteins--chicken, rice and oats, Ir Med J., 2014
CP Kerley, K Hutchinson, P Greally, D Coghlan, B Elnazir (ed.), Proceedings of the Nutrition Society 73 (OCE2), 2014, 2014
Nadeem M, Oni OA, Ryan M, Puri P, Coghlan D, Greally P, Girl with xanthogranulomatous pyelonephritis and bronchiectasis: case report., Pediatrics international : official journal of the Japan Pediatric Society, 2013
Scanlan B, Nadeem M, Ryan M, Smith O, O'Marcaigh A, Coghlan D, Acute leukaemia presenting with isolated bone pain, Archives of Disease in Childhood, 98 , (10), 2013, 771-
CW Teoh, M Mavinkurve, U Damachi, S Medani, M Waldron, D Coghlan , Vesico-ureteric reflux and renal scarring in children under 1 year of age with first urinary tract infection , PEDIATRIC NEPHROLOGY , 2011
J O'Brien, EB Williams, D Coghlan, Is ultrasound a useful tool in the diagnosis of failure to thrive? Preliminary findings from the faltering growth (FIG) study , Irish journal of medical science 179, S204-S204, 2010
M Omer, EB Williams, D Coghlan, How useful is the measurement of crp, total white cell and neutrophil counts in differentiating between bacterial and other causes of fever in children? , Irish Journal of Medical Science , 2010
M Curtin, D Coghlan , Missed vaccines, missed opportunity , Irish Journal of Medical Science , 2010
M White, E Williams, M Curtin, D Coghlan , Smaller size and its developmental associations , Acta Paediatrica, 2009
Deasy C, O'Mahony O, Coghlan D, Fitzgerald E, Isoparaffin poisoning in an 18-month-old girl., Ir Med J, 2007
McManus V, Coghlan D, Are hospital based notifications enough? Achieving accurate case ascertainment--the Southern Ireland Cerebral Palsy Register (SICPR), Ir Med J, 2005
Cerebral Palsy Registries in, Seminars in Pediatric Neurology , Seminars in Pediatric Neurology 1, 2004, pp18 - 23, [C Cans, G Surman, V McManus, D Coghlan, O Hensey, A Johnson ]
Cans C, Surman G, McManus V, Coghlan D, Hensey O, Johnson A, Cerebral palsy registries., 2004
Coghlan D, Kiing JS, Wake M, Parents' Evaluation of Developmental Status in the Australian day-care setting: developmental concerns of parents and carers., Journal of Paediatrics and Child Health 39 (1), 49-54, 2003
Coghlan D, Powell C, Treatment of childhood asthma: how do the available options compare?, Pediatric Drugs 5 (10), 685-698 , 2003
Coghlan D, Lynch B, Allcutt D, Hereditary cerebral cavernous angiomas: presentation as idiopathic familial epilepsy, Ir Med J, 2002
Coghlan D, Cranswick NE, Complementary medicine and vitamin A toxicity in children, Medical Journal of Australia , 2001
Cranswick N, Coghlan D, Paracetamol efficacy and safety in children: the first 40 years., American Journal of Therapeutics, 2000
Wake M, Coghlan D, Hesketh K, Does height influence progression through primary school grades?, Arch Dis Child, 2000
Coghlan D, Milner M, Clarke T, Lambert I, McDermott C, McNally M, Beckett M, Matthews T, Neonatal abstinence syndrome, Ir Med J, 1999
Non-Peer-Reviewed Publications
J Dinsmore, E Williams, H McCarthy, D Coghlan Journal of Human Nutrition and Dietetics 24 (3), 280-281, A pilot study to explore factors affecting faltering growth in children , Journal of Human Nutrition and Dietetics 24 (3), 280-281, 2011
Research Expertise
Description
General Paediatrics is an acute specialty caring for the undifferentiated child. It is an emerging academic specialty with a focus on clinical research and quality improvement. Since my time as a fellow at RCH Melbourne I concentrated on early child development and how clinicians and parents must collaborate to define a child's abilities in the home, school and play settings. This work included those with developmental delay and those with more severe disabilities such as cerebral palsy. More recent work has focused on interventions including Vitamin D supplementation to improve symptoms in children with Autism and Asthma. While adequate nutrition is essential many child still require daily medication and my work has also looked at improving methods of medication administration in those with acute infection, allergy and complex needs. A novel method of delivering anti-epileptic method through a feeding tube was described with great benefits for children with complex needs. Randomised Controlled trials: 1. RCT of Vitamin D supplementation in autism spectrum disorder. Randomised 42 children to receive 2000 IU Vitamin D3 daily or placebo over 20 weeks. Vitamin D had no effect on primary outcome of reducing stereotypic autistic behaviours. Trend towards reduced inappropriate speech in the Vitamin D3 treatment group. 2. RCT of Vitamin D supplementation in uncontrolled asthma. Randomised 44 children with uncontrolled asthma to receive 2000 IU Vitamin D3 or placebo over 15 weeks. Vitamin D had no effect on primary outcome of improved subjective asthma control or Fev1 on spirometry. There was a non-significant improvement in Fev1 within the placebo group. Finally we've explored variation in medication response by examining genetic variants in asthma. An association was found between Taql (exon 9) and Apal (intron 8) polymorphisms and asthma risk. IL10 levels were lower in asthmatic children with Taql polymorphisms. I've also developed national guidelines published as the WIGUAM Study (Working to Implement National Guidelines for Urine Tract Infection Assessment and Management ).Projects
- Title
- An RCT of Vitamin D3 in Uncontrolled Asthma
- Summary
- A double-blind, randomized, PL-controlled trial of vitamin D supplementation (2000 IU/day) in 44 urban, caucasian children at high latitude. Conclusion: Vitamin D3 supplementation led to a significant increase in serum 25(OH)D and decreased school days missed (p = 0.04), but no other advantageous changes in asthma parameters compared with PL.The potential negative effect of high serum 25(OH)D on pulmonary function warrant further investigation.
- Funding Agency
- National Children's Hospital Foundation
- Date From
- January 2014
- Date To
- January 2015
- Title
- Protocol for Investigation of Penicillin Allergy.
- Summary
- Feasibility Study to Implement National Protocol for Investigation of Penicillin Allergy in children
- Funding Agency
- The National Children's Hospital Foundation
- Date From
- April 2012
- Date To
- April 2013
- Title
- An RCT of Vitamin D3 in Paediatric Autism
- Summary
- A double-blind, randomised, placebo-controlled trial set in a paediatric outpatient centre at high latitude over the winter season in Dublin, Ireland (53°N). Conclusion: Vitamin D supplementation had no effect on the primary outcome with limited and inconsistent effects in children with ASD. Considering the other promising data as well as the relative safety and cheapness of vitamin D supplementation, further trials are warranted.
- Funding Agency
- The National Children's Hospital Foundation
- Date From
- Jan 2015
- Date To
- Jan 2016
- Title
- PROSPER: PaediatRic Outcomes and Serum biomarker Panel in acutE traumatic bRain injury /concussion to severe traumatic 2015-9.
- Summary
- To describe the demographics and aetiology of traumatic brain injury presenting to Irish Paediatric Emergency Departments. Concussion and mild traumatic brain injury (mTBI) are interchangeable terms.Post-concussion syndrome (PCS) occurs in 1/7 children sustaining a mTBI.Secondly to describe physician competence in this condition and to develop a best practice guideline. To elucidate biomarkers from the innate immune system that are activated in acute brain injury. Findings include preschool children have the highest incidence of head injury, mostly following a fall. There was a paucity of knowledge among all grades of medical professionals in how to manage these children. Many patients had a raised white cell count with neutrophilia. Surprisingly CD 11b neutrophil expression was not raised in mTBI on flow cytometry, but was markedly raised in the 4 most severe TBI patients.
- Funding Agency
- National Children's Hospital Foundation
- Date From
- 2016
- Date To
- 2019
- Title
- PRISM: PReterm Infection and SysteMic inflammation and neonatal outcomes.
- Summary
- This research aims to improve the understanding of the systemic inflammatory response in preterm infants and the potential for newer adjunctive therapies. In addition trying to identify immune markers that will assist in the prognosis and clinical outcomes of these preterm infants.
- Funding Agency
- The National Children's Hospital Foundation and Trinity College Dublin
- Date From
- 2016
- Date To
- 2019
- Title
- Bright Horizons Study
- Summary
- Bright Horizons Study. Neurodevelopmental follow up of preterm infants including psychological profiling at age 24 months corrected. Also to investigate the developmental outcomes of children with a history of HIE (Hypoxic Ischemic Encephalopathy).
- Funding Agency
- NCH Foundation
- Date From
- 2015
- Date To
- 2017
- Title
- FIG Study
- Summary
- Faltering growth In General paediatrics Clinic (FIG) was a 1 year study exploring the determinants of poor growth in toddlers. The effect of maternal and social factors on faltering growth (FG) are unclear from published research. A control comparison of 24 children recruited through clinics in AMNCH was undertaken (12 FG, 12 controls). Participating parents completed a health, social,and demographic questionnaire and a 7 day food diary was completed using household measures. Diaries were analysed using NETWISP for protein , fat, carbohydrate, and vitamin content. All data were entered in SPSS. There were no significant difference between FG and control groups in maternal health or social factors. There were no differences in the feeding histories between the two groups. However the mean intake of all nutrients except protein, monounsaturated fat, starch, sodium and B12 were all higher in the control group. These findings support hypothesis that poor nutritional intake is main cause of faltering growth in this group. There was a trend towards lower breast feeding rates in the FG group.
- Funding Agency
- NCH Foundation
- Date From
- 2009
- Date To
- 2010
Recognition
Representations
HSE-Acute Floor Implementation Process Group( Paediatric Representative)
National Electronic Health Record (EHR) Programme. Paediatric EHR Working Group
Chair, National Guideline Committee -Management of Urinary Tract Infection in children
Paediatric Clinical Advisor, Coeliac Society of Ireland
Paediatric expert reviewer for Irish Medical Council
Expert external case reviewer supporting Director Of Quality, CHI (Children's Hospital Ireland)
Reviewer for Irish Medical Journal
Awards and Honours
Irish Paediatric Association (IPA)- Best Oral Presentation WIGUAM Study
IPA-Best Poster "FPIES in infancy"
Paediatrician of the Year-Laya Healthcare Awards
Memberships
FRCPI-Fellow of the Royal College of Physicians, Ireland
FRCPCH (UK)-Fellow of the Royal College of Physicians and Child Health
GAPRUKI Collaboration-General and Adolescent Paediatrics UK and Ireland Member(Research Collaboration Body) -Founding member
Faculty of Paediatrics, RCPI
ERS-European Respiratory Society Member
EAACI, European Academy of Allergy and Immunology, Member
MPS-Medical Protection Society Member
Irish Paediatric Surveillance Unit (IPSU)
British Paediatric Surveillance Unit (BPSU)
Biography
Elaine is a member of the Discipline of Paediatrics with many different roles. These include working with Professor Edna Roche as a clinical trial coordinator and research assistant on several paediatric research projects. She is a clinical lecturer for the undergraduate medical students and a facilitator on the 4th Year medical student Professionalism and Scientific Module for undergraduate medical students.
Her other area of interest is in the subject of listening. This includes regular acts of listening, research, education and presentations on the topic of listening. Currently Elaine is a member of the International Listening Association (ILA) and was instrumental in securing Trinity College Dublin as the location for the 39th Annual International Listening Association Convention in June 2018.
Publications and Further Research Outputs
Peer-Reviewed Publications
Elaine O'Mullane, Care don't Carry: The Art of Responsible Listening, 2018, -
Elaine O'Mullane, Listening in Healthcare Settings, 20th June 2018, 2018, Trinity College Dublin
Elaine O'Mullane, Susan O'Connell, Edna F Roche, Hilary Hoey, How late is too late to treat with Growth Hormone? A case study, BSPED, Brighton, UK, 14-15th Nov, 2013, edited by Elaine O'Mullane , 2013
Elaine O'Mullane, Conal Hamill, Edna F Roche, Exploring the Culture of Listening Amongst Children's Nurses in an Outpatient Department A mini-ethnographic study, British Society of Paediatric Endocrinology and Diabetes, Brighton, UK, 14-15 Nov 2013, edited by Elaine O'Mullane , 2013
Jensen RB, Thankamony A, O'Connell SM, Salgin B, Kirk J, Donaldson M, Ivarsson SA, Soder O, Roche EF, Hoey H, Dunger DB, Duul A; NESGAS Group, Baseline IGF-I levels determine insulin secretion and insulin sensitivity during the first year on growth hormone therapy in children born small for gestatinal age. Results from a North European Multicentre Study (NESGAS)., Hormone Research Paediatrics, 80, (1), 2013, p38 - 46
Gallagher, P., Snow, A., Roche, E., O'Mullane, E., Hoey, H., NESGAS Grp N European Small Gestat, BONE MINERAL DENSITY ADJUSTMENT IN CHILDREN WITH SHORT STATURE, Pediatric Research, 68, 2010, p544
O'Connell, Susan M., O'Mullane, Elaine, Roche, Edna F., Hoey, Hilary M. C. V., CHANGES IN BODY COMPOSITION AS ASSESSED BY DXA FOLLOWING A YEAR OF GROWTH HORMONE TREATMENT IN CHILDREN BORN SGA, Irish Journal of Medical Science, 179, 2010, pS230
O'Connell AC, O'Connell SM, O'Mullane E, Hoey HM, Oral health of children born small for gestational age., Irish medical journal, 103, (9), 2010, p275-8
A Snow, S Hamilton, M Ryan, E Colhoun, E O'Mullane, H Hoey, Paediatric DXA interpertation - applying internationl guidelines, Hormone Research, 72, (s3), 2009, p356-
S O'Connell, A O'Connell, E O'Mullane, H Hoey, Medical, Nutritional, and Dental Considerations in Children with Low Birth Weight, Pediatric Dentistry, 31, (7), 2009, p389 - 397
Non-Peer-Reviewed Publications
Elaine O'Mullane, Emotional Intelligence, Medical Intern Teaching, Robert Graves Centre, TUH, D24, 07 January, 2020, Sandra Daly
Elaine O'Mullane, Emotional Intelligence, Theatre Staff In House Training, Tallaght University Hospital, 28 Feb, 2019, Fiona Darbey
Elaine O'Mullane, Emotional Spill Kit, Theatre Staff In House Training, Theatre Conference Room, Tallaght University Hospital, 10th May, 2019, Fiona Darbey
Elaine O'Mullane, Corine Jansen, Helen Meldrum, The Role of Listening in Delivering and Receiving Bad News, Theatre In Service Training, Tallaght University Hospital, 24 Jan, 2019
Elaine O'Mullane, Data Collection Tools, Centre for Learning and Development Academic Writing Week, Tallaght Hospital, D24, 16 January, 2018, Christina Lydon
Elaine O'Mullane, Demystifying Research, Ethics & Language of Research, Centre for Learning and Development Academic Writing Week, Tallaght Hospital, D24 , 15 Jan, 2018, Christina Lydon
Elaine O'Mullane, Corine Jansen, Helen Meldrum, The Role of Listening in Delivering and Receiving Bad News, 4th Medical Year Professionalism and Scientific Module , Trinity Campus, Tallaght Hospital, 14-12, 2017, Assistant Professor, Dr Judith Meehan
Elaine O'Mullane, Listening Engagement for Children's Nurses: Peeling away the Barriers, 19th Annual Novo Nordisk Endocrine Nurse Workshop, Heathrow, London, 12-13 June , 2014, Novo Nordisk
Fiona Mc Grane - Clinical Nurse Specialist ( Down Syndrome)
Ms Fiona Mc Grane is based within the Discipline of Paediatrics in the Trinity Centre, Tallaght University Hospital. The post is supported by Down Syndrome Ireland. Fiona holds a Diploma in Social Care awarded by Stockport University and graduated from Trinity College in 2004 in Intellectual Disability Nursing and again in 2008 after completing a Higher Diploma in Children’s Nursing. She is currently undertaking her M.Sc. in Queens Belfast in Caring for Children and Young People with Complex Health needs. She is a steering group member of the Down Syndrome Medical Interest Group in the UK and Ireland. Ms Mc Grane’s academic functions at Trinity include both education and research. She lectures Nursing and Midwifery students in the School of Nursing and also Medical Students in the School of Medicine. Her subjects of interest are Health and Down Syndrome and also how parents receive the diagnosis of their child being born with Down Syndrome.
Fiona has worked for many years within the area of disability caring for children and adults in community, residential and hospital environments. Her current role is as a Clinical Nurse Specialist for children with Down Syndrome. She is currently the only nurse in the country that specialises within the area and she provides nationwide for children and families from birth to 18 years. A Down syndrome clinic, the first clinic in Ireland is run in Tallaght University Hospital. Fiona plays an active role in clinical decision making and ensuring that the children that attend have all their medical needs addressed. Fiona receives referrals from maternity hospitals across the country, community services and also self-referrals from parents.
She is also involved in research and she played a pivotal role in setting up The National Register for Children with Down syndrome to which the data is held and managed within the Department. Ongoing research collaborations continue including the DISCO study which is carried out in the Down syndrome clinic. Fiona also holds a database for patients that attend her service in Tallaght Hospital. She has collaborated with fellow clinicians on research projects in relation to Down syndrome and continues to do so.