Endocrinology and Growth
Staff
| Cody | Declan | Dr | Paediatric Endocrinologist |
| Hoey | Hilary | Prof | Adjunct Professor in Paediatrics |
| McDonnell | Ciara | Dr | Paediatric Consultant Endocrinologist |
| Costigan | Colm | Dr | Paediatric Endocrinologist |
| Roche | Edna | Professor | Consultant Paediatric Endocrinologist |
Biography
Edna Roche is Professor in Paediatrics at the University of Dublin, Trinity College Dublin and a consultant paediatrician and paediatric endocrinologist at Childrens' Health Ireland (CHI) at Tallaght University Hospital. She qualified in Medicine at Trinity College where she also obtained her Doctorate. She holds a postgraduate qualification from the NUI, Membership and Fellowships from the Royal College of Physicians of Ireland, Edinburgh and the Royal College of Paediatrics and Child Health London. Dr Roche completed her clinical training in Ireland, the Middlesex Hospital and the Childrens Hospital Great Ormond Street London and in North America. She has a particular interest in Management, undertaking an MBA in Strategic management at Trinity for which she was awarded 1st Place. She has extensive academic experience and introduced many innovations and new programmes to the University. She is an enthusiastic clinical teacher encouraging her students in self-directed and life-long learning. In recognition of her teaching she was awarded the Provosts award for teaching excellence. She has supervised many postgraduate students in both clinical medicine and management and published over 50 peer reviewed papers. She is a keen researcher whose research objective is to: optimise clinical care; promote health; prevent unnecessary complications; and enhance quality of life, through collaboration nationally and internationally. Clinical research areas include Paediatric Diabetes and Endocrinology (rare syndromes, growth and development which underpin health in childhood and adult life) and Down Syndrome. Amongst her many research achievements she has developed the Irish Childhood Diabetes National Register, a major asset in diabetes care and the Down Syndrome Register. She has extensive research collaborations nationally and internationally. She is a member of a number of important research networks such as the Hvidoere International study group in diabetes and EURODIAB. She is a contributor to many professional associations at home and abroad. She was a Ministerial appointee to the National Paediatric Hospital Development Board for the new Childrens Hospital. Dr Roche is former Director or Research at Down Syndrome Ireland and a member of the Steering Group of the Down Syndrome Medical Interest Group (DSMIG) Ireland and UK. She Chairs the Nutrition Council of the Irish Heart Foundation, is a member of the Clinical Advisory Group for Obesity of the Royal College of Physicians of Ireland and is a member of the Clinical Advisory Group of the Faculty of Paediatrics, Royal College of Physicians of Ireland through which she makes a significant contribution in shaping the future of Child Health in Ireland.
Publications and Further Research Outputs
Peer-Reviewed Publications
Christina Meade, Ruth Martin, Ann McCrann, Jacqueline Lyons, Edna Roche, Dietary intake and growth in children with Prader"Willi syndrome, Journal of Human Nutrition and Dietetics, 2021
McKenna A, O'Regan M, Ryder K, Fitzgerald H, Hoey H, Roche E., Incidence of childhood type 1 diabetes mellitus in Ireland remains high but no longer rising, Acta Paediatrica, 2021
Pembroke S, Roche EF, Sleath B, Brenner M, Hilliard C, Cody D, Coyne I , Developing a video intervention to improve youth question-asking and provider education during paediatric diabetes clinic encounters: the Promoting Adolescents Communication and Engagement study, Patient Education and Counseling, 2021
Meade C, Martin R, McCrann A, Lyons J, Meehan J, Hoey H, Roche E, Prader-Willi Syndrome in children: Quality of life and caregiver burden., Acta paediatrica (Oslo, Norway : 1992), 2020
Dean Huggard, Lynne Kelly, Emer Ryan, Fiona McGrane, Niamh Lagan, Edna Roche, Joanne Balfe, T. Ronan Leahy, Orla Franklin, Derek G. Doherty, Eleanor J. Molloy, Increased systemic inflammation in children with Down syndrome, Cytokine, 127, 2020, p154938
Feighan SM, Hughes M, Maunder K, Roche E, Gallagher L. , A profile of mental health and behaviour in Prader Willi Syndrome, J Intellect Disabil Res. , 64, (2), 2020, p158 - 169
Niamh Lagan, Dean Huggard, Fiona Mc Grane, Timothy Ronan Leahy, Orla Franklin, Edna Roche, David Webb, Aengus O'Maricaigh, Des Cox, Afif Elkuffash, Peter Greally, Joanne Balfe, Eleanor J Molloy, Multiorgan involvement and management in children with Down Syndrome, Acta Paediatrica, (1), 2020
Pembroke S, Lagoda N, Brenner M, Hilliard C, Cody D, Roche E, Coyne I , How do you measure self-management behaviour in adolescents with type 1 diabetes mellitus? an integrative review of self-management measurement instruments, Archives of Disease in Childhood, 103, (Suppl 3), 2019
Griffiths S, Loveday C, Zachariou A, Behan LA, Chandler K, Cole T, D'Arrigo S, Dieckmann A, Foster A, Gibney J, Hunter M, Milani D, Pantaleoni C, Roche E, Sherlock M, Springer A, White SM, Childhood Overgrowth Collaboration, Tatton-Brown K., EED and EZH2 constitutive variants: A study to expand the Cohen-Gibson syndrome phenotype and contrast it with Weaver syndrome., American journal of medical genetics. Part A, 179, (4), 2019, p588-594
Huggard D, Koay WJ, Kelly L, McGrane F, Ryan E, Lagan N, Roche E, Balfe J, Leahy TR, Franklin O, Moreno-Oliveira A, Melo AM, Doherty DG, Molloy EJ., Altered Toll-Like Receptor Signalling in Children with Down Syndrome., Mediators of inflammation, 2019, 2019, p4068734
Roche E, McKenna A, Ryder K, Fitzgerald H, O'Regan M, Hoey H. The Irish Childhood Diabetes National Register , The frequency of diabetic ketoacidosis at type 1 diabetes onset in a national incident cohort over a 5 year period , Pediatric Diabetes, 45th Annual Meeting of the International Society for Pediatric and Adolescent Diabetes (ISPAD), Boston, USA, Oct30-Nov 2 2019, Volume 20, (Issue S28), Wiley, 2019, pp108-
Wegmann MG, Jensen RB, Thankamony A, Frystyk J, Roche E, Hoey H, Kirk J,, Increases in bioactive IGF do not parallel increases in total IGF-I during growth hormone treatment of children born SGA, J Clin Endocrinol Metab. , 2019
Coyne, I Pembroke S, Lagoda N, Hillard C, Cody D, Roche E & Brenner M. , Determining adolescents, parents and professionals' views concerning the educational needs of adolescents with Type 1 diabetes and content preferences for short self-management videos and a question prompt sheet., , Archives of Disease in Childhood , 9th Europaediatrics Congress, Dublin, Ireland, , 13 -15 June. , 104 , ((Suppl 3) ), BMJ Group , 2019, ppA252 - A253
Metwally N, Macken A, O'Regan M, Fitzgerald H, McDonnell C, O'Gorman CS, Molloy E, Roche EF, Evaluation of diabetes related complications and endothelial dysfunction in adolescents with Type 1 diabetes, Horm Res Paediatr , 57th Annual ESPE Meeting , Athens, Greece , 27-29 September 2018, 90 , ( (suppl 1) ), 2018, pp216.-
McMorrow AM, Connaughton RM, Magalhães TR, McGillicuddy FC, Hughes MF, Cheishvili D, Morine MJ, Ennis S, Healy ML, Roche EF, Tremblay RE, Szyf M, Roche HM, Personalized Cardio-Metabolic Responses to an Anti-Inflammatory Nutrition Intervention in Obese Adolescents: A Randomized Controlled Crossover Trial., Molecular nutrition & food research, 2018
Mahon M, Amaechi G, Slattery F, Sheridan AL, Roche EF, Fifteen-minute consultation: Polydipsia, polyuria or both., Archives of disease in childhood. Education and practice edition, 2018
McKenna A, Sandys N, Ryder K, Metwally N, Brennan A, O'Regan M, Hoey MCV, Roche EF, Single Centre Experience - Clinical Presentation and Frequency of Paediatric Diabetic Ketoacidosis (DKA) At Diagnosis over a 5-Year Period., Irish medical journal, 111, (3), 2018, p714 - 716
Lateva M, Kassim A, Meade C, Maher R, McCrann A, Roche E, Poor weight gain in Prader Willi Syndrome - not always over-restriction consider coeliac disease, Horm Res Paediatr , 57th Annual ESPE Meeting, Athens, Greece , 27-29 September 2018, 90, ((suppl 1):), 2018, pp437-
Huggard D, McGrane F, Lagan N, Roche E, Balfe J, Leahy TR, Franklin O, Moreno A, Melo AM, Doherty DG, Molloy EJ, Altered endotoxin responsiveness in healthy children with Down syndrome., BMC immunology, 2018
Meade C, Martin R, Crowe C, Lyons J, McCrann A, Meehan J, Hoey H, Roche E , Quality of Life and the Impact of Caring for a Child with Prader Willi Syndrome, Joint Irish Paediatric Association and Welsh Paediatric Society Annual Meeting, Clayton Hotel, Ballybrit Galway, 7- 8th December 2018, 2018
McGrane F, Roche EF, THe Adolescent with Down Syndrome in Ireland, Joint Irish Paediatric Association and Welsh Paediatric Society Annual Meeting, Clayton Hotel, Ballybrit Galway, 7- 8th December 2018, 2018
Patterson CC, Harjutsalo V, Rosenbauer J, Neu A, Cinek O, Skrivarhaug T, Rami-Merhar B, Soltesz G, Svensson J, Parslow RC,... Roche EF, .. Green A, Trends and cyclical variation in the incidence of childhood type 1 diabetes in 26 European centres in the 25 year period 1989-2013: a multicentre prospective registration study., Diabetologia, 62, (3), 2018, p408 - 417
O'Riordan F, McDonnell C, Roche EF, Screening for Coeliac Disease and IgA deficiency in the Paediatric Diabetes Population, Joint Irish Paediatric Association and Welsh Paediatric Society Annual Meeting, Clayton Hotel, Ballybrit Galway, 7- 8th December 2018, 2018
Roche EF, McGowan A, Koulouri O, Turgeon MO, Nicholas AK, Heffernan E, El-Khairi R, Abid N, Lyons G, Halsall D, Bonomi M, Persani L, Dattani MT, Gurnell M, Bernard DJ, Schoenmakers N, A novel IGSF1 mutation in a large Irish kindred highlights the need for familial screening in the IGSF1 deficiency syndrome, 89, (6), 2018, p813 - 823
Hoey H, Lange K, Skinner TC et al Hvidoere International Study Group., Hvidoere Smiley Faces: International diabetes quality of life assessment tool for young children, Paediatric Diabetes, 2017
Nicholas, A.K., Jaleel, S., Lyons, G., Schoenmakers, E., Dattani, M.T., Crowne, E., Bernhard, B., Kirk, J., Roche, E.F., Chatterjee, V.K., Schoenmakers, N., Molecular spectrum of TSHß subunit gene defects in central hypothyroidism in the UK and Ireland, Clinical Endocrinology, 86, (3), 2017, p410-418
Skinner TC, Lange KS, et al Hvidoere Study Group., Targets and teamwork:Understanding differences in paediatric diabetes centres treatment outcomes, Pediatric Diabetes., 2017
Edna Roche, Anne McGowan, Olympia Koulouri et al, A novel IGSF1 mutation in a large Irish kindred highlights the need for family screening in the IGSF1 deficiency syndrome, Endocrine Abstracts (2017) 51 P060 , 45th Meeting of the British Society for Paediatric Endocrinology and Diabetes, Newcastle, UK, 22 - 24 November 201, 51, (51 P060 ), 2017
Martin R, Meade C, Mc Crann A , Roche E, Exploring the growth and nutritional status in children with Prader-Willi syndrome, Endocrine Abstracts , 45th Meeting of the British Society for Paediatric Endocrinology and Diabetes, Newcastle, UK, 22 - 24 November 201, 51 P023 , 2017
Wegmann MG, Thankamony A, Roche E, Hoey H, Kirk J, Shaikh G, Ivarsson S, Soder O, Dunger DB, Juul A, Jensen RB, The exon3-deleted growth hormone receptor gene polymorphism (d3-GHR) is associated with insulin and spontaneous growth in short SGA children (NESGAS), Growth Hormone and IGF Research, 35, 2017, p45 - 51
Nadeem, M., Roche, E.F., Bone mineral density in short individuals; how can we interpret it?, Irish Medical Journal, 109, (8), 2016
Roche, E.F , McKenna, A.M., Ryder, K.J., Brennan, A.A., O"Regan, M., Hoey, H.M., Is the incidence of type 1 diabetes in children and adolescents stabilising? The first 6 years of a National Register , European Journal of Pediatrics, 175, (12), 2016, p1913-1919
Ajay Thankamony Rikke Beck Jensen Susan M O'Connell Felix Day Jeremy Kirk Malcolm Donaldson Sten-A Ivarsson Olle Söder Edna Roche Hilary Hoey Ken K Ong David B Dunger Anders Juul, Adiposity in children born small for gestational age is associated with β-cell function, genetic variants for insulin resistance and response to growth hormone treatment, The Journal of clinical endocrinology and metabolism, 101, (1), 2016, p131 - 142
B eck Jensen R, Thankamony A, Day F, Scott RA, Langenberg C, Kirk J, Donaldson M., Ivarsson SA, Soder O, Roche E, Hoey H, et al, Gnetic markers of insulin sensitivity and insulin secretion are associated wth spontaeous postnatal growth and response to growth hormone treatment in short SGA children: the North European SGA Study (NESGAS), Journal of Clinical Endocrinology and Metabolism, 100, (3), 2015, pE503 - E507
Neu, A., Lange, K., Barrett, T., Cameron, F., Dorchy, H., Hoey, H., Jarosz-Chobot, P., Mortensen, H., Robert, J.-J., Robertson, K., de Beaufort, C., Aanstoot, H.J., Åman, J., Barrett, T., de Beaufort, C., Cameron, F., Castaño, L., Castro-Correia, C., ChiarelliF, Chiari, G., Danne, T., Dorchy, H., Fisher, L.K., HoeyH, Jarosz-Chobot, P., Kaprio, E.A., Kocova, M., Lange, K., Mortensen, H.B., Neu, A., Njølstad, P.R., Palmert, M., Phillip, M., Pociot, F., Robert, J.J., Robertson, K.J., Roche, E.F., Schönle, E.J., Shalitin, S., Skinner, T., Swift, P., Urakami, T., Vanelli, M., Classifying insulin regimens - difficulties and proposal for comprehensive new definitions, Pediatric Diabetes, 16, (6), 2015, p402-406
Nadeem M, Roche EF ("Senior"), Thyroid disorders in girls with Turner syndrome and the influence of the underlying karyotype, Irish Medical Journal, 108, (3), 2015, p93 - 94
Mohamed S, Roche EF, Hoey HM, Mode of initial presentaiton and chromosomal abnormalities in Irish patients with Turner syndrome: a single-centre expreience., Journal of Pediatric Endocrinology and Metabolism, 28, 2015, p1215 - 1218
Lewis S, Coveney J, Roche EF, Kyriakou A, An assessment of the hypothalamic-pituitary-adrenal axis in children with prader-willi syndrome (PWS), endocrine Abstracts , 43rd Annual meeting of the British Society for Paediatric Endocrinology and Diabetes, Sheffield, UK, 25-27 November 2015, 39, (7), 2015, pp7-
S. Mohamed, E.F. Roche, H.M.C.V. Hoey , High prevalence of spontaneous puberty in patients with turner syndrome in tertiary referral center in ireland, Acta Endocrinologic, XI, (1), 2015, p60 - 63
Jensen, R.B., Thankamony, A., Day, F., Scott, R.A., Langenberg, C., Kirk, J., Donaldson, M., Ivarsson, S.-A., Söder, O., Roche, E., Hoey, H., Juul, A., Ong, K.K., Dunger, D.B., Genetic markers of insulin sensitivity and insulin secretion are associated with spontaneous postnatal growth and response to growth hormone treatment in short SGA children: The North European SGA Study (NESGAS), Journal of Clinical Endocrinology and Metabolism, 100, (3), 2015, pE503-E507
Roche EF, McKenna A, Ryder K, Brennan A, O'Regan M, Hoey H, The incidence of childhood type 1 diabetes in Irealnd and the National Childhood Diabetes Register., Irish Medical Journal, 107, (9), 2014, p278 - 281
Nicholas AK, Jaleel S, Schoenmakers E, Dattani M, Roche E, Chatterjee VK, Schoenmakers N , Congenital central hypothyroidism due to a TSHB mutation with uniparental inheritance, Endocrine Abstracts , 42nd Annual meeting of the British Society for Paediatric Endocrinology and Diabetes, Winchester, UK, 12-14 November 2014, 36, (P83 ), 2014
Nadeem M, Roche EF ("Senior"), Body fat distribution in Turner syndrome and the influence of puberty., Irish Medical Journal, 107, (8), 2014, p260-
Duignan A, Kennedy C, Canas-Martinez A, Gildea D, Jamaludin MA, Moore M, Meehan J, Nadeem M, Roche EF , Attitudes of parents and staff towards medical students on the paediatric wards., Irish Medical Journal, 107, (1), 2014, p26 - 28
O'Connell SM, Lynch S,Coyle D, McDermott M, O'Sullivan M, Roche E, Quinn F, Cody D , The Incidence of Childhood Gonadoblastoma over 15 years in the Republic of Ireland , hormone Research in Paediatrics , ESPE 53rd Annual Meeting, , convention Centre Dublin, 18-20 September 2014, 82, (supplement 1), 2014, pp156-
M Nadeem, EF Roche ("Senior"), Height in Turner syndrome: Does Growth Hormone Therapy Have Impact?, Irish Medical Journal, 107, (2), 2014, p61 - 62
Nadeem M, Roche EF , Turner syndrome awareness of health issues, Irish Medical Journal, 107, (7), 2014, p222-
Roche EF ("Senior"), The National Paedaitric Diabetes Register and its impact on healthcare, Irish Medical Journal, 107, (7), 2014, p197 - 198
Roche, E.F. ("Senior"), The national paediatric diabetes register and its impact on healthcare, Irish Medical Journal, 107, (7), 2014, p197 - 198
Nadeem M, Roche EF ("Senior"), Bone Mineral Density in Turner's syndrome and the influence of pubertal development., Acta Paediatrica, 103, (1), 2014, pe38 - 42
Jensen RB, Thakamony A, Day F, Kirk J, Donaldson M, Ivarsson S, Soden O, Roche E, Hoey H, Juul A, Ong K, Dunger D , Genetic Markers of insulin Resistance are associated with GH Response in Short SGA Children: the North European SGA Study, Hormone Research in Paediatrics , ESPE 53rd Annual Meeting , Convention Centre Dublin, 18-20 September 2014, Volume 82 , (Supplement 1), 2014, pp42-
O'Donovan C, Roche EF, Hussey J, The energy cost of playing active video games in children with obesity and children of a healthy weight, Pediatr Obes, 9, (4), 2014, p310 - 317
Letshwiti J, O'Mullane E, Hoey H, Roche E ("Senior") , The Effect of Long term GH Therapy in Discordant Twins where one twin is born small for gestational age: A case control study, Hormone Research in Paediatrics , ESPE 53rd Annual Meeting , Convention Centre Dublin, 18-20 September 2014, 82, (Supplement 1), karger, 2014, 257
Nadeem M, Roche EF , Health-related quality of life in Turner syndrome and the influence of key features., Journal of Pediatric Endocrinology and Metabolism, 27, (3-4), 2014, p283-9-
Jensen RB, Thankamony A, O'Connell Sm, Roche EF, et al, A randomised controlled trial evaluating IGF1 titration in contras to curren GH dosing stategies in childen born small for gestatin age: the North european Small-for-Gestational-Age Study., Eur J Endocrinolo, 171, (4), 2014, p509 - 518
Nadeem M, Roche EF ("Senior"), Health-related quality of life in Turner Syndrome and th influence of key features, J Pediatr Endocrinol Metab, 27, (3), 2014, p283 - 289
George S, Hoey HMCV, Costigan C, Murphy N, Roche EF, O'Riordan SMP , Improved Health-related Quality of life with insulin therapy in children with cystic fibrosis related diabetes: a prospective Cohort study, hormone Research in Paediatrics , ESPE 53rd Annual Meeting , convention Centre Dublin, 18-20 September 2014, 82, (supplement 1), 2014, pp103-
Cameron, F.J., de Beaufort, C., Aanstoot, H.-J., Hoey, H., Lange, K., Castano, L., Mortensen, H.B., Aman, J., Atchison, J.A., Barret, T., Bjoernedalen, H., Castro-Correia, C., Chiarelli, F., Chiari, G., Dahl-Jørgensen, K., Daneman, D., Danne, T., Dorchy, H., Fisher, L., Kaufman, F., Garandeau, P., Greene, S., Holl, R., Hougaard, P., Jarosz-Chobot, P., Kaprio, E., Kitasato, N.M., Kocova, M., Lebenthal, Y., Martul, P., Meier, L.K., Neu, A., Njolstad, P., Palmert, M., Phillips, M., Pociot, F., Robert, J.J., Robertson, K.J., Roche, E., Schoenle, E., Shalitin, S., Skinner, T.C., Skovlund, S., Sovik, O., Swift, P., Tsou, R., Urakami, T., Vanelli, M., Lessons from the Hvidoere International Study Group on childhood diabetes: Be dogmatic about outcome and flexible in approach, Pediatric Diabetes, 14, (7), 2013, p473-480
Nadeem M, Roche EF ("Senior"), Bone mineral density in Turner's syndrome, Hormone Research in Paediatircs, 9th Joint Meeting of Paediatric Endocrinology, Milan, Italy, September 2013, 80, (Supp 1), 2013, pp378-
Nadeem M, Roche EF ("Senior"), Are Girls with Turner syndrome obese?, Irish Medical Journal, 106, (6), 2013, p188
O'Mullane E, Roche EF, Hamill C, Exploring the culture of listening amongst children's nurses in an outpatient department: A mini-ethnographic study., 41st Meeting of the British Society for Paediatric Endocrinology and Diabetes., Brighton, UK, November 2013, 2013
Jensen, R.B., Thankamony, A., O'Connell, S.M., Salgin, B., Kirk, J., Donaldson, M., Ivarsson, S.-A., Söder, O., Roche, E., Hoey, H., Dunger, D.B., Juul, A., Baseline IGF-I Levels Determine Insulin Secretion and Insulin Sensitivity during the First Year on Growth Hormone Therapy in Children Born Small for Gestational Age. Results from a North European Multicentre Study (NESGAS)on behalf of the NESGAS group, Hormone Research in Paediatrics, 80, (1), 2013, p38-46
Nadeem M, Roche EF ("Senior"), Coeliac disease in Turner syndrome, Archives of Disease in Childhood, 98, (8), 2013, p649 - 650
Khadr SN, Carmichael P, Holf V, Roche EF, Viner R., Study of gender identity disorder in children and adolescents., Hormone Research in Paediatircs, 9th Joint Meeting of Paediatric Endocrinology, Milan, Italy, September 2013, 80, (Supp 1), 37, 2013, pp37-
O'Donovan C, Roche EF, Hussey J, The energy cost of playing active video games in children with obesity and children of a healthy weight., Pediatric obesity, 2013
O'Mullane, O'Connell, Roche EF, Hoey H., How late is too late to treat with Growth Hormone? A case study., 41st Meeting of the British Society for Paediatric Endocrinology and Diabetes., Brighton, UK, November 2013, 2013
O'Malley G, Hussey J, Roche E.("Senior"), A pilot study to profile the lower limb musculoskeletal health in children with obesity., Pediatr Phys Ther. , 24, 2012, p292 - 298
G O'Malley, J Hussey, Edna F Roche ("Senior"), A Poilot Study to Profile the Lower Limb Musculoskeletal Health in Children with Obesity, Paediatric Physical Therapy, 24, (3), 2012, p292 - 298
C Machold, G Judge, A Mavrinac, J Elliott, AM Murphy, Edna F Roche ("Senior"), Social Netowrking Patterns/Hazards Among Teenagers, Irish Medical Journal , 105, (5), 2012, p151 - 152
Montasser Nadeem, Edna F Roche , Bone Health in Children and Adolescents with Turner Syndrome, Journal of Pediatric Endocrinology and Metabolism, 25, (9-10), 2012
Ressell M Viner, B While, T Barrett, D Candy, P Gibson, Edna F Roche et al, Assessment of childhood obesity in secondary care: OSCA consensus statement, Arch Dis Child Edu Pract Ed, 97, (3), 2012, p98 - 105
Edna F Roche ("Senior"), Irish Childhood Natinal Diabetes Register, Irish Medical Journal, 104, (9), 2011, p2011-
Roche, E. ("Senior"), Hospital based management - An irish perspective, International Journal of Pediatric Obesity, 5, (SUPPL. 1), 2010
Viner, R.M., Roche, E., Maguire, S.A., Nicholls, D.E., When does childhood obesity become a child protection issue?, BMJ (Online), 341, (7769), 2010, p375-377
Viner RM, Roche E, Maguire SA, Nicholls DE., Childhood protection and obesity: a framework for practice. , British Medical journal, 341, 2010, p307 - 310
O'Riordan SM, Hindmarsh P, Hill NR, Matthews DR, George S, Greally P, Canny G, Slattery D, Murphy N, Roche E, Costigan C, Hoey H., Validation of Continuous Glucose Monitoring in children and adolescents with cystic fibrosis - a prospective cohort study, Diabetes Care, 2009
S O'Connell, E O;'Mullane, J Murphy, E Roche, M Sheridan, H Hoey, Maternal smoking in pregnancy as a risk factor for Small for Gestation Age (SGA) births., British Medical Journal, 338, (2), 2009, pb481 - e 1-7
McKenna A, Hoey H, Roche EF ("Senior"), Rising Incidence of Type 1 Diabetes Mellitus in children and adolescents under 15 years in teh Republic of Ireland 2008 (Preliminary Figures), Endroceine Abstracts (2009) 23 OC 6.1, 37th Annual meeting of the British Society for Paediatric Endocrinology and Diabetes (BESPED), Reading, UK, November 10 - 12, 2009
Aisling Myers, Ieuan hughes, John Achermann, Sally Anne Lynch, Edna F Roche, Hilary Hoey, 46 XY DSD: A case of clinical and biochemical conflict, Endocrine Abstracts, British Society for Paediatric Endocrinology and Diabetes, Reading, UK, 10th - 12th November, 23, 2009, pp29-
A Myers, J McHugh, A McCrann, N Crossadell, E Roche, H Hoey, Turner Syndrome in Young Adults: Where are They now?, Irish Paediatric Association Meeting, Mullingar, May, 2008
S O'Riordan, P Hindmarsh, C Costigan, N Murphy, E Roche, H Hoey, Insulin, C-peptide concentrations and insulin sensitivity in children with cystic fibrosis related diabetes, 47th Annual Meeting of the European Society for Paediatric Endocrinology, Istanbul, Turkey, 20 - 23 September, 2008, ESPE, 27 - 27pp
J Murphy, M Philip, S Macken, J Meehan, E Roche, P Mayne, M O'Regan, H Hoey, Thyroid Dysfunction in Down's Syndrome and Screening for Hypothyroidism in Children and Adolescents using Capillary TSH Measurement, Journal of Pediatric Endocrinology & Metabolism, 21, (2), 2008, p155 - 163
S O'Riordan, H Colgan, S George, C Costigan, C Corridon, J Caffrey, E Roche, H Hoey, Diet in children with Cystic Fibrosis Related Diabetes, The Joint Faculty of Paediatrics and Irish Paediatric Assocation Meeting, Limerick, May, 2007
S George, S O'Riordan, H Hoey, E Roche, C Costigan, N Murphy, quality of life and family burden in children with cystic fibrosis related diabetes., Hormone Research, 68, 2007, p89 - 90
S O'Connell, E O'Mullane, M Sheridan-Sheridan-Pereira, E Roche, H Hoey, Long-term growth and clinical asssessment of children born small for gestation age., Hormone Research, 68, (Supplemental 1), 2007, ppo1 - 67
S O'Connell, E O'Mullane, M Sheridan-Pereira, E Roche and H Hoey., Long-term growth and clinical assessment of children born small for gestational age. , Hormone Research, 68, (1), 2007, p1-67
S O'Diordan, E Roche, S George, H Hoey, B Elnazir, P Greally, G Canny, C Costigan, D Slatter, N Murphy, Conitinuous Glucose Monitoring Enhances the Detection of Cystic Fibrosis Related Diabetes in Children with Cystic Fibrosis, Diabetologic, 50, (Supp 1), 2007, p190-
S O'Riordan, E Roche, S George, H Hoey, B Elnazir, P Greally, G Canny, C Costigan, D Slattery, N Murphy, Continuous Glucose monitoring Enhances the Detection of Cystic Fibrosis Related Diabetes in Children with Cystic Fibrosis, The Joint Faculty of Paediatrics and Irish Paediatric Association Meeting, Limerick, May, 2007
S O'Riordan, S Ennis, A Green, S George, E Hand, C Costigan, E Roche, H Hoey, Genetic Aspects of Cystic fibrosis Related Diabetes, The Joint Faculty of Paediatrics and Irish Paediatric Association Meeting, Limerick, May, 2007
S O'Connell, E O'Mullane, E Roche, M Sheridan-Pereira, H Hoey, Follow-up Assessment of Children Born Small for Gestational Age at the Coombe Women's Hospital (1999-2001), Irish Perinaltal Society, Belfast, N Ireland, March , 2007
S O'Connell, E O'Mullane, A Juul, DB Dunger, EF Roche, H Hoey, Auxological characteristics of children born Small for Gestation Age without catch up growth and response to Growth Hormone Treatment, British Society for Paediatric Endocrinology and Diabetes (ESPED), Cambridge, England, September, 2007, BESPED, 29 - 29pp
S O'Riordan, S George, H Hoey, E Roche, C Hilary, C Costigan J Caffery, C Corridon, E Hand, N Murphy, Dietary assessment of children and adolescents with cystic fibrosis with and without diabetes, Hormone Research, 68, 2007, p111-
S O'Riordan, S George, C Costigan, E Roche, H Hoey, The prevalence of IGT and CFRD by continuous glucose monitoring in children with Cystic Fibrosis, Royal College of Paediatrics and Child Health, York, England, April, 2006
J Hussey, J Gormley, C Bell, EF Roche, H Hoey, Exercise Tolerance and Physical Activity Levels in Children Referred to a Weight Reduction Clinic, Irish Medical Journal, 99, (2), 2006, p46 - 47
O'Riordan S, Hoey H, Roche EF, Costigan C, Murphy N, Screening for Diabetes in Children with Cystic Fibrosis. A new approach to CGMS analysis., 32nd Annual meeting of the International Society for Paediatric and Adolescent Diabetes (ISPAD), Cambridge, UK, September 6 - 9, 2006
Hussey, J., Gormley, J., Bell, C., Roche, E.F., Hoey, H., Exercise tolerance and physical activity levels in children referred to a weight reduction clinic. , Irish Medical Journal, 99, (2), 2006, p46-47
F Healy, A Brennan, H Fitzgerald, F Cleary, E Roche, H Hoey, Insulin Pump Therapy in Children and Adolescents with Type 1 Diabetes Attending a Tertiary Referral Centre, The Irish and American Paediatric Society, Kilkenny, Ireland, September 2006, 2006
S O'Connell, L Doyle, E O'Mullane, E Roche H Hoey, Silver Russell Syndrome (SRS): No distinction between IUGR and SGA when considering Growht Hormone Treatment?, British Society of Paeditarc Endocrinology & Diabetes, Cork, September, 2006
S O'Riordan, S George, C Costigan, E Roche, H Hoey, The prevalence of glucose intolerance and diabetes assessed by continuous glucose monitoring sensors in cystic fibrosis children., Royal College of Paediatrics And Child Helath, University of York, April, 2006, British Society for Paediatric Endocrinology and Diabetes
S O'Riordan, S George, C Costigan, E Roche, H Hoey, The Prevelence of CFRD in 167 Children, American Diabetes Association, Washington DC, June , 2006
S O'Riordan, S George, C Costigan, E Roche, H Hoey, Homeostasis and Continuous Glucose Monitoring in CF Childrne, Diabetes UK, March, 2006
S O'Rioran, S George, C Costigan, E Roche, H Hoey, Can CGMS enhance diagnosis of CFRD in 167 CF Children., American Diabetes Association, Washington DC, June , 2006
S O'Riordan, S George, C Costigan, E Roche, H Hoey, CGMS in Cystic Fibrosis children, ts this the screening tool we should be using for early detection of CF related Diabestes., ISPAD, 2006
F Healy, A Brennan, H Fitzgerald, F Cleary, E Roche, H Hoey, Insulin Pump Therapy in Children and Adolescents with Type 1 Diabetes Attending a Tertiary Referral Centre, Proceedings of The Irish and American Paediatric Society 38th Annual Meeting, 2006, pp33 - 33
J Meehan, E Roche, P Greally H Hoey., Sleep abnormalities in children with Prader Willi Syndrome., Hormone Research, 64, (Suppl 1), 2005, p291 - 291
S O'Connell, M Sheridan-Pereira, H Hoey, E Roche, Small for gestation age (SGA) children - Childhood growth outcomes and final adult height., Journal of Maternal-Fetal & Neonatal Medicine, 18, (3), 2005, p203-
S O'Connell, E O'Mullane, JP Murphy, EF Roche, M Sheridan-Pereira, H Hoey, Follow of assessment of children born small for gestation age at the Coombe Women's Hospital (1999 - 2001), Irish Journal of Medical Science, 174, (4), 2005, p1 - 71
S O'Riordan, S George, C Costigan, E Roche, H Hoey, Cystic Fibrosis Diabetes - The Dublin Experience, International Society of Paediatric Adolescence Diabetes (ISPAD), Krakow, 2005, 2005
Meehan J, Roche EF, Quinn E, Crosadell N, Hoey HMCV, The effects of growth hormone treatment on growth and body composition in children and adolescents with Prader Willi Syndrome, Hormone Research, 64, (S 1), 2005, p297-
J Meehan, E Roche, P Greally, H Hoey, Sleep abnormalities in children with Prader Willi Syndrome, European Society for Paediatric Endocrinology Scientfiic Meeting, 2005, 2005
Roche EF ("Senior author"), Menon A, GillD , Hoey HMCV , Clinical Presentation of Type 1 Diabetes, Paediatric Diabetes , 6, (2), 2005, p75 - 8
Hoey, H., Roche, E.F., Meehan, J., Auxology and growth assessment, Irish Medical Journal, 98, (6), 2005
J Murphy, HMCV Hoey, M Philip, EF Roche, S Macken, P Mayne, D Duff, M O'Keefe, D McShane, E Fogarty, M O'Regan, Guideline for the Medical Management fo Irish Children and Adolescents with Down Syndrome, Irish Medical Journal, 98, (2), 2005, p48 - 52
L Doyle, S O'Connell, EF Roche, H Hoey, Silver Russell Syndrome - The spectrum of Clinical features, growth outcome and moleculare genetics in a study of 9 patients attending a paediatric Endocrinology clinic., Irish Journal of Medical Sciences , 174, (4), 2005, p1 - 71
S O'Connell, H Hoey, M Sheridan-Pereiar, E Roche, E Quinn, N Croasdell, Small for gestational age children who fail to catch up - are the criteria for growth hormone therapy to stringent?, Hormone Research, 64, (Supplemental 1), 2005
Meehan J, Roche EF, Quinn E, Croasdell N, Hoey HMCV, The effects of growth hormone treatment on growth and body composition in children and adolescents with Prader Willi Syndrome, ESPE/LWPES 7th Joint Meetin Paediatric Endocrinology, Lyon, France, September 21 - 24, 2005
S O'Riordan, S George, C Costigan, E Roche, H Hoey, Cystic Fibrosis Diabestes and non-diabetes, North American CF Meeting, Baltimore, USA, October , 2005
S O'Connell, H Hoey, M Sheriden-Pereirs, E Roche, E Quinn, E O'Mullane, The case for individualising treatment with growth hormone therapy in children born small for gestation age (SGA) who fail to catch up., British Society of Paediatric Endocrinology & Diabetes, Bristol, England, November, 2005
H Hoey, E Roche, J Meehan, Effect of discontinuation of growth hormone treatment on risk factors for cardiovascular disease in abdolescents born small for gestation age, Hospital Doctor of Ireland, 9, (3), 2004
M Parvin, H Hoey, E Roche, C Costigan, Treatment Outcome in Turner Syndrome, Irish Medical Journal, 97, (1), 2004, p12 - 15
Roche EF., Charmandari E., Dattani M, Hindmarsh PC , Blood Pressure in children and adolescents with Congenital Adrenal Hyperplasia, (21-Hydroxylase Deficiency): a preliminary report., Clinical Endocrinology , 58, 2003, p589 - 596
Roche EF, Samaan C, Brennan Aa, Fitzgerald H, Hoey HMCV, The role of continuous glucose monitoring in the management of type 1 diabetes, Irish Journal of Medical Science, 2003
Delangeh K, O'Riordan S, Brennan A, Roche EF, Hoey HMCV, Diabetes Type 1 and Associated Coeliac Disease, Irish Journal of Medical Science, 2003
Hussey J, Dowling C, Al Basairi I, Roche EF, O'Riordan S, Croasdell N, Spelman M, Hoey HMCV, Physical Activity levels, Exercise Tolerance and Psychological Profile in children referred to an Obesity Clinic, Irish Journal of Medical Science, 2003
Hussey J, Dowling C, Al Basairi I, Roche EF, O'Riordan S, Croasdell N, Spelman M, Hoey HMCV, Physical Activity Levels, Exercise Tolerance and Psychologiacl Profile in Children referred to an Obesity Clinic, Irish Paediatric Association Meeting, Atlone, Ireland, May 9 - 10, 2003
Roche EF, Hoey HMCV, Warnign of the type 2 epidemic? Not so simple obesity, Irish Jorunal of Medical Science, 2003
Roche EF ("Senior"), Childhood Obesity - why should we be worried? Editorial. , Irish Medical Journal , 96, (4), 2003, p100 - 102
O'Riordan S, Delanghe K, Brennan A, Leen G, Roche EF, Greally P, Hoey HMCV, Cystic Fibrosis related diabetes (CFRD) and impaired glcose tolerance in the National Chilren's Hospital, Tallaght., Irish Paediatric Association Meeting, Atlone, Ireland, May 9 - 10, 2003
O'Riordan S, Delangeh K, Brennan A, Leen G, Roche EF, Greally P, Hoey HMCV, Cystic Fibrosis related diabetes (CFRD) and impaired glucose tolerance in the National Chilren's Hosptial, Tallaght., Irish Journal of Medical Science, 2003
Mohamed S, Roche EF, Quinn E, Eltahir M, Hoey HMCV, Meddle ear disease, hearing loss and learning difficulty in Irish girls with Turner syndrome, Irish Journal of Medical Science, 2003
E Roche, H Lewy, H Hoey, Z Laron, Differences between males and females in the seasonality of birth and month of clinical onset of disease in children with type 1 diabetes mellitus in Ireland, Journal of Pediatric Endocrinology & Metabolism, 16, (5), 2003, p779 - 782
H Hoey, E Roche, J Meehan, Paediatric Endocrinology, Hospital Doctor of Ireland, 9, (3), 2003
Delanghe K, O'Riordan S, Brennan A, Roche EF, Hoey HMCV, Diabetes Type 1 and Associated Coeliac Disease, Irish Paediatric Assocation Meeting, Athlone, Ireland, May 9 - 10, 2003
Roche EF, Charmandari E, Dattani M, Hindermarsh PC, Blood Pressure in patients with Congenital Adrenal Hyperplasia, 21 - Hbdroxylase Deficiency, 41st Annual Meetin of the european Society for Paediatic Endocrinology (ESPE), Madrid, Spain, September 25 - 28, 2002
Roche EF ("Senior"), the Management of Intersex Conditions, Annual Paediatric Endocrinology Meeting, Bromsgrove, Birmingham, UK, November , 2002
E Roche, A Menon, D Gill, H Hoey, National Incidence of Type 1 Diabetes in Childhood and Adolescence, Irish Medical Journal, 95, (4), 2002, p115 - 118
E Roche, A Menon, D Gill, H Hoey, Incidence of Type 1 Diabetes Mellitus in Childrne Ages Under 15 years in the Republic of Ireland, Journal of Paediatric Endocrinology & Methabolism, 15, 2002, p1191 - 1194
Roche EF ("Senior"), Obesity - The Clinician's View, XXIV Congress of the European Society of Cardiology, Berlin, Germany, Aug 31 - Sept 4, 2002
Roche EF, Hoey HMCV, Warning of the type 2 epidemic? Not so simple obesity, Joint Irish Paediatric Association/Ulster Paediatric Society Meeting, Northern Ireland, May 10 - 11, 2002
Roche EF, Hoey HMCV, Clincial Features of Type 1 Diabetes, 28th Annual meeting of the International Society for Paediatric and Adolescent Diabetes (ISPAD), Graz, Austria, September 18 - 21, 2002
Roche EF ("Senior"), Strategic Management, MA Healthcare Management, Distance Learning Study Text Book, 2nd Edition, Institute of Public Administratin Publicastions, Dublin, 2002
Roche EF, Samaan C, Brennan A, Fitgerald H, Hoey HMCV, The role of continuous glocose monitoring in the management of type 1 diabetis, Irish Paediatric Association meeting, Dublin, Ireland, November 28, 2002
Roche EF, Charmandari E, Dattani M, Hindmarsh PC, Blood Pressure in patiens with Congenital Adrenal Hyperplasia, 21 - Hydroxylase Deficiency, Hormone Research, 58, (Sup 2), 2002, p45-
Roche EF, Hoey HMCV, Clinical Features of Type 1 Diabetes, Journal of Paediatic Endocrinology and Metabolism, 15, 2002, p1087 - 1087
Roche EF, Menon A, Gill D, Hoey HMCV, The Incidence of Type 1 Diabetes in children aged under 15 years in the Republic of Ireland, Journal of Paediatic Endocrinology and Metabolism, 15, (8), 2002, p1191 - 1194
Roche EF, Hindmarsh PC, A clincal delemma. SEx of rearing? A case report of 11-B Hydroxylase deficiency, Joint meeting of the European Society of paediatic Endocrinology (ESPE) and the Lawson Wilkins Society (North American Society of Paediatric Endocrinology), Montreal, Canada, 2001
Roche EF, Menon A, Gill D, Hoey HMCV, The Incidence of Insulin Dependent Diabetes Mellitus in the Irish Republic, Joint meeting of the European Society of Paediatric endocrinology (ESPE) and the Lawson Wilkins Society (North American Society of Paedaitric Endocrinology), Montreal, Canada, 2001
Roche EF, Menon A, Gill D, Hoey HMCV, The Incidence fo Insulin Dependent Diabetes Mellitus in the Irish Republic, Paediatric Research , 49, (6), 2001, p93 - 93
Roche EF, Hindmarsh PC, A clinical delemma. Sex of Rearing? A case report of 11-B hydroxylase deficiency, Paediatric Research, 49, (6), 2001, p120 - 120
Roche EF ("Senior"), Strategic Management, MA Healthcare Management, 1st Edition, Dublin, Institute of Public Administratino Publication, 1996
Fearon, U., Clarke, D., McKenna, T.J., Cunningham, S.K., Morrison, P.J., Hughes, A.E., Nevin, N.C., Russell, C.F.J., Powell, D., Hadden, D.R., Bonar, B.D., Smith, D.F., Darke, C., Hetherton, A.M., Smyth, P.P.A., Hunter, S.J., Harper, R., Ennis, C.N., Crothers, E., Sheridan, B., Atkinson, A.B., Bell, P.M., Hayes, F., McKenna, T.J., Sheahan, K., McCabe, M., Conway, D.J., O'Higgins, N.J., Smyth, P.P.A., Garry, P., Laski, J., Brosnan, L., Collins, P., Devlin, J.G., Heaney, A.P., Atkinson, A.B., Curry, W.J., Johnston, C.F., Buchanan, K.D., Sheridan, B., Mirakhur, M., Fiad, T.M., Culliton, M., Cunningham, S.K., McKenna, T.J., Lynn, J.A., O'Shea, D.B., Meeran, M.K., Jackson, J.A., Bloom, S.R., Hunter, S.J., Ennis, C.N., Sheridan, B., Atkinson, A.B., Bell, P.M., Hayes, F., McKenna, T.J., Sheehan, K., Hayes, F., Heffernan, A., McKenna, T.J., Nugent, A.G., McGurk, C., Rutherford, R., Hayes, J.R., Johnson, G.D., Cusack, Y.A., O'Riordan, D., McDermott, E.W.M., O'Higgins, N.J., Smyth, P.P.A., Roche, E.F., McCormack, I., Tempany, E.T., Smyth, P.P.A., Smith, D.S., Deegan, P., Owens, D., Gilligan, S., Collins, P., Johnson, A., Tomkin, G.H., Heaney, A., Harper, R., Ennis, C., Sheridan, B., Atkinson, A.B., Bell, P.M., Wiggam, M.I., O'Kane, M.J., Harper, R., Atkinson, A.B., Hadden, D.R., Trimble, E.R., Bell, P.M., Dunne, F.P., Heath, D.A., Rollason, T., Ratcliffe, W.A., Marshall, T., Cronin, C.C., Barry, D.G., Crowley, B., Ferriss, J.B., Kinsley, B.T., Simonson, D.C., Jones, R., Owens, D., Collins, P., Johnson, A., Tomkin, G.H., Fiad, T.M., Culliton, M., Cunningham, S.K., McKenna, T.J., O'Shea, D.B., Lambert, P.D., Bloom, S.R., Herbert, J., O'Hare, J.A., Abuaisha, F., Razza, Q., Geoghegan, M., Barrett, E., Clarke, D., Fearon, U., Cunningham, S.K., McKenna, T.J., Irish endocrine society - Proceedings of the 19th annual meeting of the Irish endocrine society held at University College Hospital, Galway in October 1994, Irish Journal of Medical Science, 164, (4), 1995, p320-328
Non-Peer-Reviewed Publications
Edna F Roche ("Senior"), "Medical Management of Down Syndrome Health Surveillance Guidelines" , Annual Meeting of the Faculty of Paediatrics, Royal College of Physicians of Ireland, , Royal College of Physicians of Ireland, Kildare Street, May 12th 2017, 2017, Faculty of Paediatrics, Royal College of Physicians of Ireland,
Edna F Roche ("Senior"), "Optimising Care in Down Syndrome", Royal College of Physicians (RCPI) Masterclass Broadening Horizons in Down Syndrome, Royal College of Physicians Of Ireland (RCPI), Kildare St, 1st February , 2017, Royal College of Physicians (RCPI)
Edna Roche, Symposium on Adolescent Health, 29th Novrember 2017, In:Lost in Transition, 2017, Trinity Centre for Health Sciences, Tallaght Hospital
Edna F Roche ("Senior"), "Who's Feeding the Kids Online? Digital Food Marketing and Children in Ireland - the Doctor's Perspective" , "Who's Feeding the Kids Online? Digital Food Marketing and Children in Ireland - Irish Heart Foundation Seminar, he Lighthouse Cinema, Dublin, 15th June, 2016, Irish Heart Foundation
Edna F Roche ("Senior"), "The Irish Childhood Diabetes National Register (ICDNR) -the Current Picture of Type 1 Diabetes in children and Adolescents in Ireland" , Inaugural Meeting of the Irish Paediatric Endocrinology and Diabetes Group, Athlone, 27th-28th May , 2016
Edna Roche, "PROMISE -Implications for clinical pathways in primary and secondary care" Respondant, Findings from the PROMISE programme and next steps for treatments of obesity in children and young peoplePaediatric Research in Obesity Multi-modal Intervention and Service Evaluation Programme (PROMISE) , University College London, Institute of Child Health London, 10th June, 2015
Roche, Meet the Expert- Challenges in the Management of Extreme Obesity (2), ESPE 53rd Annual Meeting , Convention Centre Dublin, 20 September 2014, 2014, European society for Paediatric Endocrinology
Edna F Roche (, "Extreme obesity in childhood" , Faculty of Paediatrics Autumn Conference, Royal College of Physicians Of Ireland (RCPI), Kildare St, Friday October 10th , 2014
Edna Roche and Hilary Hoey, ESPE 53rd Annual Meeting , 18-20 September 2014, In: 53rd Annual Meeting of the European Society of Paediatric Endocrinology (ESPE), 2014, Convention Centre Dublin
Edna Roche , 28th ESPE Summer School, 15-17 September 2014, In:28th ESPE Summer School, 2014, Barretstown Castle, Co Kildare
Edna Roche, Russell Viner and OSCA, Progressing Paediatrics Workshop " Managing Childhood Obesity", 24th October 2014, In: Progressing Paediatrics Workshop " Managing Childhood Obesity", 2014, Royal College Of Paediatrics and Child Health, London
Edna Roche ("Senior"), Meet the Expert- Challenges in the Management of Extreme Obesity, ESPE 53rd Annual Meeting , Convention Centre Dublin, 18 September 2014, 2014, European society for Paediatric Endocrinology
Edna F Roche , "Assessment of Obese children and obesity co-morbidities using the OSCA guidelines", Progressing Obesity Management: Training Course in Management of Obesity , Royal College of Paediatrics and Child Health (RCPCH), London, 24th October, 2014, Edna Roche and Russell Viner
Edna Roche, Festschrift Clinical Challenges in Paediatrics and Child Health and Opportunities for the Future , 17th September 2010, In:Clinical Challenges in Paediatrics and Child Health and Opportunities for the Future , 2010, Tallaght Hospital Dublin
Murphy JP, Philip M, Roche EF, Hoey HMCV, comprehensive Surveillance study of children and adolescents with down Syndrome, Birth to 16 years in the Eastern Regional Health Authority, 2003
Roche EF ("Senior"), changing structures and practices in the Irish health service, Department of Health and Chidlren, Dublin, Forum on Medical manpower, 1999
Research Expertise
Projects
- Title
- Irish Childhood Diabetes National Register
- Summary
- Diabetes Epidemiology: Childhood Type 1 diabetes (T1D), fatal if untreated is associated with major life limiting complications if poorly controlled. Good diabetes management requires accurate disease data. No such data were available in Ireland. Following a baseline study of national T1D epidemiology, the Irish Childhood National Diabetes Register (ICDNR), a core infrastructure in childhood diabetes, was established to provide accurate data regarding T1D in children and young people in Ireland. The ICDNR now in its 12th year, is governed by a highly skilled Steering Group, with a broad range of expertise (Medical, Nursing, IT, Statistics, Health Informatics). It has extensive collaborations: International (Eurodiab, NI Register, Hvidore, ISPAD) and National (Paediatricians, Diabetologists, RCPI, PCRS, HSE, Diabetes Ireland, TUD (formerly IT Tallaght). As a result of our work accurate national data are available for the first time to inform health planning, resource allocation, enable audit, research and optimise clinical care. Targeted interventions are now possible as patient subgroups are identifiable. Robust data and forecasts are provided to the HSE (by ICDNR). Reliable incidence data are available ( considered "a Basic Health Indicator" by WHO), of national and international importance and Irish T1D epidemiology monitored. Prevalence Modelling: Current research includes prevalence modelling and forecasting in T1D in association with Professor Myra O'Regan, Department of Statistics and Computer Science. Diabetic Ketoacidosis Prevention: Some children develop severe metabolic decompensation (Diabetic Ketoacidosis, DKA) at diabetes diagnosis which can be fatal or result in a trajectory of poor metabolic control with increased diabetes related complications in adult life. This is of major international concern. The Irish Childhood Diabetes National Register (ICDNR) is monitoring national DKA rates before and after a 2 year collaborative national DKA prevention campaign to gain insight into factors associated with the development of DKA and its prevention. Analysis of the baseline data demonstrates a very high rate of DKA at diagnosis in those with T1D. The intervention phase is in progress with print and radio campaigns and targeted campaigns directed at healthcare professionals. A digital campaign has been developed for phase two. This study is a collaboration involving Diabetes Ireland, TUD (formerly IT Tallaght) and the ICDNR.
- Funding Agency
- National Children's Hospital Foundation
- Date From
- 1/1/2008
- Date To
- ongoing
- Title
- International Monitoring of Diabetes Epidemiology
- Summary
- Eurodiab is an international collaboration of 26 European Childhood Diabetes Registers representing 22 countries. Following assessment and site visit the ICDNR has been a participant since 2011. Eurodiab monitors the epidemiology of T1D across Europe exploring trends in incidence which may ultimately provide clues to the underlying aeitology.
- Date From
- 2011
- Title
- Down Syndrome National Register
- Summary
- Down Syndrome (DS) or trisomy 21 is one of the most common congenital genetic conditions. Ireland is thought to have the highest incidence of DS in the world. While much is known about Down Syndrome there is much that we need to learn. The National Register for Children with Down Syndrome was established in 2015 to increase our knowledge about Down Syndrome in Irish children with the ultimate aim of improving the quality of care and quality of life for children with DS and their families. The unique prospective National Register for DS was developed in 2015, with extensive collaborations. The DS register is a key infrastructure to provide reliable data to inform clinical care, support audit, research and enhance the quality of life for children with DS and their families. This prospective national Register will define the epidemiology of Down Syndrome in Ireland and provide data to inform appropriate healthcare planning, clinical audit, and enable monitoring of the implementation of the medical management guidelines for those with DS (MMG) developed by our group. These data, including the number of children born with Down syndrome in Ireland each year, the area in which they live etc ,will enable more informed decision making and optimise resource allocation leading to better clinical outcomes. The Register will also expand our knowledge of DS. It will help ascertain if certain problems and illnesses are more prevalent or more severe in children with Down syndrome. It will provide more accurate evidence based information for counselling families and may enable screening programmes or early intervention to prevent avoidable secondary disability which has been so successful for those with DS who develop thyroid disease for example. The immediate research plan is to define incidence, demographics and co-morbidities in newborns with DS. The longitudinal arm will explore the natural history of co-morbidities, complications, access to and health care utilisation etc. In addition Down Syndrome provides an important model to evaluate immune function. Through defining the epidemiology and systematically studying the issues faced by children with DS and their families the DS Register will enhance the health and well being of Children with Down syndrome in Ireland. The DS Register is governed by a Steering Group with a broad expertise and includes parent representation. The Register is hosted by Tallaght University Hospital and funded by the NCHF.
- Funding Agency
- National Childrens' Hospital Foundation (NCHF)
- Date From
- 2015
- Title
- PACE Study
- Summary
- Intervention to improve youth question-asking and provider education during paediatric diabetes visits.
- Funding Agency
- National Childrens' Research Centre NCRC
- Date From
- 2018
Recognition
Awards and Honours
The John Good Prize, The University of Dublin, Trinity College Dublin
The Sir Charles Harvey Award for outstanding performance in postgraduate management education, the Irish Management Institute
The Provost's Award for Teaching Excellence, The University of Dublin, Trinity College Dublin
Healthcare Team of the Year Award 2016 (Large Hospital category) awarded to the Paediatric and Adolescent Diabetes Service, NCH Tallaght, Irish Healthcare Awards
Best Poster Prize at the 45th Annual Meeting of the British Society for Paediatric Endocrinology and Diabetes, Newcastle, UK. November 22nd-24th 2017.
The Inaugural Jennings Medal awarded by the Irish Endocrine Society Awarded for the Best Paediatric Paper submitted to the Irish Endocrine Society National Meeting, October 11th 2019, Galway.
Dr. Ciara Mc Donnell
Consultant in Paediatric Endocrinology, Paediatrics
Consultant in Paediatric Endocrinology, School Office - Medicine
Publications and Further Research Outputs
Peer-Reviewed Publications
H. C. Bartels , 1 A. A. Geraghty,1 E. C. O'Brien,1 A. Kranidi,2 J. Mehegan,2 C. Yelverton,1 C. M. McDonnell,3 and F. M. McAuliffe, Fetal Growth Trajectories and Their Association with Maternal, Cord Blood, and 5-year Child Adipokines, Journal of Nutrition and Metabolism, 2020
McGlacken-Byrne SM, Hawkes CP, Flanagan SE, Ellard S, McDonnell CM, Murphy NP, The evolving course of HNF4A hyperinsulinaemic hypoglycaemia--a case series., Diabetic medicine : a journal of the British Diabetic Association, 2014
McDonnell CM, Donath SM, Werther GA, Cameron FJ, Twice-daily variable insulin regimens: proportions of insulin types have little impact on glycaemic control in primary school-aged children., Diabetic medicine : a journal of the British Diabetic Association, 2008
McDonnell CM, Northam EA, Donath SM, Werther GA, Cameron FJ, Hyperglycemia and externalizing behavior in children with type 1 diabetes., Diabetes care, 2007
Ismail D, Gebert R, Vuillermin PJ, Fraser L, McDonnell CM, Donath SM, Cameron FJ, Social consumption of alcohol in adolescents with Type 1 diabetes is associated with increased glucose lability, but not hypoglycaemia., Diabetic medicine : a journal of the British Diabetic Association, 2006
Ward BK, Cameron FJ, Magno AL, McDonnell CM, Stuckey BG, Ratajczak T, A novel homozygous deletion in the calcium-sensing receptor ligand-binding domain associated with neonatal severe hyperparathyroidism., Journal of pediatric endocrinology & metabolism : JPEM, 2006
McDonnell CM, Zacharin MR, Maternal primary hyperparathyroidism: discordant outcomes in a twin pregnancy., Journal of paediatrics and child health, 2006
Rankins D, Wellard RM, Cameron F, McDonnell C, Northam E, The impact of acute hypoglycemia on neuropsychological and neurometabolite profiles in children with type 1 diabetes., Diabetes Care, 2005
McDonnell CM, Pedreira CC, Vadamalayan B, Cameron FJ, Werther GA, Diabetic ketoacidosis, hyperosmolarity and hypernatremia: are high-carbohydrate drinks worsening initial presentation?, Pediatric diabetes, 2005
Nguyen T, McDonnell CM, Zacharin MR, Primary ovarian failure and deletions of the long arm of chromosome 3., Journal of pediatric endocrinology & metabolism : JPEM, 2005
Bharucha T, Brown J, McDonnell C, Gebert R, McDougall P, Cameron F, Werther G, Zacharin M, Neonatal diabetes mellitus: Insulin pump as an alternative management strategy., Journal of paediatrics and child health, 2005
McDonnell CM, Benn DE, Marsh DJ, Robinson BG, Zacharin MR, K40E: a novel succinate dehydrogenase (SDH)B mutation causing familial phaeochromocytoma and paraganglioma., Clinical endocrinology, 2004
Simm PJ, McDonnell CM, Zacharin MR, Primary adrenal insufficiency in childhood and adolescence: advances in diagnosis and management., Journal of paediatrics and child health, 2004
McDonnell CM, Harris M, Zacharin MR, Iodine deficiency and goitre in schoolchildren in Melbourne, 2001., The Medical journal of Australia, 2003
McDonnell CM, Zacharin MR, Adrenal cortical tumours: 25 years' experience at the Royal Children's Hospital, Melbourne., Journal of paediatrics and child health, 2003
McDonnell CM, Coleman L, Zacharin MR, A 3-year prospective study to assess uterine growth in girls with Turner's syndrome by pelvic ultrasound., Clinical endocrinology, 2003
A. M. Hopkins, C. McDonnell, N. P. Breslin, C. A. O'Morain and A. W. Baird, Omeprazole increases permeability across isolated rat gastric mucosa pre-treated with an acid secretagogue, The Journal of pharmacy and pharmacology, 54, (3), 2002, p341-7
Breslin NP, McDonnell C, O"morain C, Surgical and smoking history in inflammatory bowel disease: a case-control study., Inflammatory bowel diseases, 1997
Non-Peer-Reviewed Publications
Mc Donnell C, Brittle, bowed or broken, on overview of metabolic bone disease, Irish College of Public Health Medicine Winter meeting in October 2012, 2012
Carroll A, Moloney S, Mc Donnell C, Monavari A, Murphy NP., Audit of Children with Persistant Hyperinsulinaemic Hypoglycaemia Attending the Childrens University Hosptal over a 15 Year Period, Department of Endocrinology and the National Centre for Inherited Metabolic Disorders, Childrens University Hospital, Temple Street, Dublin, 2008
Glavin P,Mc Donnell C, Dempsey E., Candidiasis in a tertiary nicu- prophylaxis or not, Coombe Women & Infants University Hospital, Dublin, 2007
Glavin P, Mc Donnell C, Dempsey E, Candidiasis in a tertiary nicu- prophylaxis or not, Coombe Women & Infants University Hospital Dublin, 2006
White M, Mc Donnell C, Devenney D, Corcoran F, murphy NP, Use of continuous subcutaneous insulin pumps in a paediatric diabetes centre, Childrens University Hospital, Temple Street, Dublin, 2006
White M, Mc Donnell C, Devenney D, Corcoran F, Murphy NP, Use of continuous subcutaneous insulin pumps in a paediatric diabetes centre, Childrens University Hospital, Temple Street, Dublin, 2006
O'Conor J, Mc Donnell C, Hughes JAF, Manning R., A study on growth in children with classical Galactosaemia, Childrens University Hospital, Temple Street Dublin, 2006
Breslin N. P, Mc Donnell C, O' Morain C., Smoking and surgical history in inflammatory bowel disease - a case control study, Gastroenterology Unit, Meath and Adelaide Hospitals, Trinity Medical School, Dublin, 1995
Research Expertise
Projects
- Title
- The AOIFE study.
- Summary
- Antenatal Osteogenesis Imperfecta Foetal Evaluation study - a joint UK Ireland study
- Funding Agency
- Temple Street Foundation
- Date From
- July 2019
- Date To
- July 2021
- Title
- Are early nutrition, maternal and environmental factors associated with problematic childhood eating behaviours at 5 and 10 years of age?
- Summary
- The ROLO Study is a longitudinal, birth cohort of mothers and children who were recruited at 13 weeks' gestation for a healthy eating intervention, in Dublin, Ireland. They have been followed up at multiple time points; 13, 20, 28 and 34 weeks' gestation; birth, 3 and 6 months; 2 and 5 years; and at present are being followed-up at 9-11 years. Of the 759 infants born into the ROLO Study, 403 mother-child dyads were followed-up at 5 years and it is anticipated that 500 mother-child dyads will be followed-up at the 9-11 year time point. We aim to determine if early nutrition (breastfeeding duration, timing of introduction of complementary foods), maternal factors (dietary intakes, wellbeing, eating behaviours) and environmental factors (socioeconomic status, childcare arrangements) are associated with childhood eating behaviours at 5 and 9-11 years. We also aim to determine if eating behaviour at age 5 years is predictive of eating attitudes at age 9-11 years.
- Funding Agency
- The NCH foundation, Tallaght.
- Date From
- July 2019
- Date To
- July 2021
Recognition
Memberships
Irish Medical Council Registration Number: 21036
Medical Council of Victoria Registration Number: 338598
European Society of Paediatric Endocrinology (ESPE)
Publications and Further Research Outputs
Peer-Reviewed Publications
Thankamony A, Jensen RB, O'Connell SM, Day F, Kirk J, Donaldson M, Ivarsson SA, Söder O, Roche E, Hoey H, Ong KK, Dunger DB, Juul A., 1. Adiposity in Children Born Small for Gestational Age Is Associated With â-Cell Function, Genetic Variants for Insulin Resistance, and Response to Growth Hormone Treatment., J Clin Endocrinol Metab. , 101 (1), (doi: 10.1210/jc.2015), 2016, p131 - 142
J Meehan, H Hoey, À comprehensive study of irish children with Prader Willi Syndrome aged 2 to 14 years: Demographics, clinical features, laboratory, auxology, polysomnography, quality of life, behaviour and the effects of growth hormone treatment, International Journal of Pediatric Obesity, 5, (Suppl 1), 2010, p60-
H Hoey, Management of common non-specific paediatric presentations, Irish College of General Practioners, Annual Scientific Meeting, Kilkenny, June, 2010, ICGP, 13 - 13pp
H Hoey, Tackling childhood obesity, Irish College of General Practioners, Annual Scientific Meeting, Kilkenny, June, 2010, ICGP, 13 - 13pp
H Hoey, The use of growth references for school-aged children and adolescents, International Journal of Pediatric Obesity, 5, (Suppl 1), 2010, p23-
G O'Malley, J Hussey, M Hannon-Fletcher, S Jarochowicz, H Hoey, Ediatorial Europena Childhood Obesity Group Meeting "Moving Towards Health", International Journal of Pediatric Obestiy, 5, (Suppl 1), 2010, p4-
N Shields, J Hussey, J Murphy, J Gormley, H Hoey, The relationship between body composition, activity and fitness in children with Down Syndrome, Internationl Journal of Pediatric Obestiy, 5, (Suppl 1), 2010, p59-
C Foley, F McEilligott, J Lyons P Greally, H Hoey, E Roche, Frequency of sleep disordered breathing in a population of obese children and adolescents attending a multidisciplinary weigth management clinic, Internationl Journal of Pediatric Obesity, 5, (Suppl 1), 2010, p60 - 61
T Savage, E Roche, K McCarthy, H Hoey, Screening detected elevated anti tissue transglutaminase antibodies in asymptomatic children with type 1 diabetes - when to biopsy?, Pediatric Diabetes, 10, (S 11), 2009, p37 - 37
H Hoey, Promoting good health and well-being in children and adults with Down Syndrome, 10th World Down Syndrome Congress, Dublin, Ireland, Proceddings, August, 2009, p40-
H Hoey, Psychosocial factors are associated with metabolic control in adolescents: research from the Hvidoere Study Group on Childhood Diabetes, Pediatric Diabetes, 10, (sup 13), 2009, p9 - 12
S O'Connell, R Jensen, B Salgin, E O'Mullane, H Hoey, et al, Changes in body composition as assesed by DXA scan after one year of high dose growth hormone treatment in children born SGA. Results from the NESGAS group, Hormone Research, 72, (s3), 2009, p445 - 445
B Salgin, R Jensen, S O'Connell, H Hoey et al, Effect of growth hormone treatment on insulin secretion and sensitivity in relation to growth of children born small for gestation age, Hormone Research, 72, (s3), 2009, p446 - 446
A Snow, S Hamilton, M Ryan, E Colhoun, E O'Mullane, H Hoey, Paediatric DXA interpertation - applying internationl guidelines, Hormone Research, 72, (s3), 2009, p356-
S O'Connell, E O;'Mullane, J Murphy, E Roche, M Sheridan, H Hoey, Maternal smoking in pregnancy as a risk factor for Small for Gestation Age (SGA) births., British Medical Journal, 338, (2), 2009, pb481 - e 1-7
S O'Connell, A O'Connell, E O'Mullane, H Hoey, Medical, Nutritional, and Dental Considerations in Children with Low Birth Weight, Pediatric Dentistry, 31, (7), 2009, p389 - 397
R Jensen, S O'Connell, H Hoey et al, Insulin-like growth factor-1, d3-GRD gene polymorphism, prematurity and height at start as determinants of one year growth response during high dose GH; preliminary results from the NESGA study (NESGA), Hormone Research, 72, (s3), 2009, p440 - 440
R Jensen, S O'Connell, B Salgin, H Hoey et al, Phenotypic characteristics of short childen born SGA. Baseline data from the North European small for gestational age study (NESGAS), Hormone Research, 72, (s3), 2009, p440 - 441
O'Riordan SM, Hindmarsh P, Hill NR, Matthews DR, George S, Greally P, Canny G, Slattery D, Murphy N, Roche E, Costigan C, Hoey H., Validation of Continuous Glucose Monitoring in children and adolescents with cystic fibrosis - a prospective cohort study, Diabetes Care, 2009
A Myers, J McHugh, A McCrann, N Crossadell, E Roche, H Hoey, Turner Syndrome in Young Adults: Where are They now?, Irish Paediatric Association Meeting, Mullingar, May, 2008
C Pfleger, HB Mortensen, C Herder, BO Roep, H Hoey, HJ Aanstoot, M Kocova, NC Schloot, Association of IL-1ra and adiponectin with C-peptide and remission in patients with type 1 diabetes, Diabetes, 57, 2008, p929 - 937
C Pfleger, H.B. Mortensen, L.Hansen, C. Herder, B.O. Roep, H. Hoey, H-J. Aanstoot, M. Kocova, N. Schloot, Association of IL-1ra and adiponectin with C-peptide and remission in patients with type 1 diabetes, Diabetes, 57, (4), 2008, p929 - 937
C Pfleger, H Mortensen, L Hansen, C Herder, H Hoey et al, Association of IL-1ra and adiponectin with C-peptide and remission in patients with type 1 diabetes, FOCIS 2008, Germany, 2008, 2008
H Hoey, C deBeaufort, T Skinner, P Swift, S Skovlund, H Mortensen, F Cameron, Good parent well-being is associated with better metabolic control and greater quality of life in 2062 adolescents with type 1 diabetes, Hormone Research, 70, (suppl 1), 2008, p54 - 54
C deBeaufort, C Skinner, P Swift, H Aanstoot, H Hoey, et al, Intensive insulin management - An attitude not a regimen: the Hvidoere study group for childhood diabetes: center differences study, Hormone Research, 70, (Suppl 1), 2008, p202 - 203
Murphy J, Philip M, Macken S, Meehan J, Roche E, Mayne PD, O'Regan M, Hoey HM., Thyroid dysfunction in Down's Syndrome and screening for children and adolescents using capillary TSH measurements, Journal of Pediatric Endocrinology & Metabolism , 21, (2), 2008, p155-163
J Murphy, M Philip, S Macken, J Meehan, E Roche, P Mayne, M O'Regan, H Hoey, Thyroid Dysfunction in Down's Syndrome and Screening for Hypothyroidism in Children and Adolescents using Capillary TSH Measurement, Journal of Pediatric Endocrinology & Metabolism, 21, (2), 2008, p155 - 163
T Leahy, D Webb, H Hoey, K Butler, Varicella Zoster Virus associated acute aseptic meningitis without exanthem in an immunocompetent 14-year-old-boy, The Pediatric Infectious Disease Journal, 27, (4), 2008, p1 - 2
J Svensson, T Wilkin, S Porksen, H Hoey et al, Influence of age and BMI increase the first month after diagnosis on the rate of remission innewly onset type 1 diabetes. Results from the Hvidoere Study Group, Pediatric Diabetes, 9, (S10), 2008, p31 - 32
Lotte B Nielsen, Sven Porksenmm, H Hoey, et al, TCF7L2 Gene Associates with Loss of residual Beta-Cell Function and Postprandail GLP-1 in Young Patients with New Onset Type 1 Diabetes, Results from the Hvidore Study Group, Diabetes, 68yh Scientific Sessions, , 37 , (supp 1,), 2008, p1674-P - 1674-P
C DeBeaufort, C Skinner, P Swift, H Jan Aanstoot, H Hoey, et al, Intensive insulin management - An attitude not a regimen: The Hvidoere study group for childhood diabetes: center differences study., 47th Annual Meeting fo teh European Scoiety for Paediatric Endocrinology, Istanbul, Turkey, 20 - 23 September , 2008, ESPE, 202 - 203pp
Stephen O'Riordan, Peter Hindmarsh, Colm Costigan, Nuala Murphy, Edna Roche, Hilary Hoey, Insulin, C-peptide concentrations and insulin sensitivity in children with cystic fibrosis related diabetes, Hormone Research, 70, (suppl 1), 2008, p27 - 27
H Hoey, C deBeaufort, T Skinner, et al, Good parent well-being is associated with better metabolic control and greater quality of life in 2062 adolescents with type 1 diabetes. The Hvidoere study group, 47th Annual Meeting of the European Society for Paediatric Endocrinology, Istanbul, Turkey, 20 - 23 September, 2008, ESPE, 54 - 54pp
S O'Riordan, P Hindmarsh, C Costigan, N Murphy, E Roche, H Hoey, Insulin, C-peptide concentrations and insulin sensitivity in children with cystic fibrosis related diabetes, 47th Annual Meeting of the European Society for Paediatric Endocrinology, Istanbul, Turkey, 20 - 23 September, 2008, ESPE, 27 - 27pp
J Svensson, T Wilkin, S Porksen, H Hoey, et al, Infulence of age and BMI increase during the first month after diagnosis on the rate of remission in newly onset type 1 diabetes. Results form the Hvidoere Study Group, 34th Annual Meeting of the International Society for Pediatric and Adolescent Diabetes (ISPAD) , Durban, South Africa, 13 -16 August, 2008, ISPAD, 31 - 32pp
H Hoey, C Debaufort, T Chas Kinner, et al, Good Parent Well-Being is Associated with Better Metabolic Control, Less Family Burden and Better Quality of Life in 2062 Adolescents with Type 1 Diabetes, Diabetes, 68th Scientific Sessions, June, 37, (supp 1,), 2008, p1674-P-
L Nielsen, S Porksen, H Hoey, et al, the Hvidore Study Group, TCF7L2 Gene Associates with Loss of Residual Beta-Cell function and Postprandial GPL-1 in Young Patients with New Onset Type 1 Diabetes. Results from the Hvidore Study Group, Diabetes, 57, (Supp 1), 2008, pA465-
J Swensson, T Wilkin, S Porksen, H Hoey, M Kocova, Influence of age and BMI increase during the first month after diagnosis on the rate of remission in newly onset type 1 diabetes. Results from the Hvidoere Study Group, Pediatric Diabetes, S 10, 2008, p31 - 32
H Hoey, Paediatric Endocrinology, Faculty GP CME Scheme, Leixlip, March, 2008, The Irish College of General Practitioners
FJ Cameron, TC Skinner, CE de Beaufort, H Hoey, PGF Swift et al, Are family factors universally related to metabolic outcomes in adolescents with Type 1 Diabetes?, Diabetic Medicine, 25, (4), 2008, p463 - 468
H Hoey, C Debeaufort, T skinner, et al, for the Hvidore Study Group, Good Parent Well-Being is Associated with Better Metabolic Control, Less Family Burden and Better Quality of Life in 2062 Adolescents with Type 1 Diabetes, Diabetes, 57, (Supp 1), 2008, pA498-
J McHugh, I Okefor, A Myers, H Hoey, Case Report:Marfan's Syndrome, Irish Paediatric Association Meeting, Mullingar, May, 2008
S O'Connell, E O'Mullane, H Hoey, Early detction of SGA is crucial, Irish Medical Times, April, 2007
S George, S O'Riordan, H Hoey, E Roche, C Costigan, N Murphy, quality of life and family burden in children with cystic fibrosis related diabetes., Hormone Research, 68, 2007, p89 - 90
S O'Riordan, H Colgan, S George, C Costigan, C Corridon, J Caffrey, E Roche, H Hoey, Diet in children with Cystic Fibrosis Related Diabetes, The Joint Faculty of Paediatrics and Irish Paediatric Assocation Meeting, Limerick, May, 2007
S O'Diordan, E Roche, S George, H Hoey, B Elnazir, P Greally, G Canny, C Costigan, D Slatter, N Murphy, Conitinuous Glucose Monitoring Enhances the Detection of Cystic Fibrosis Related Diabetes in Children with Cystic Fibrosis, Diabetologic, 50, (Supp 1), 2007, p190-
S O'Riordan, S Ennis, A Green, S George, H Hoey, C Costigan, Genetics of cystic fibrosis related diabetes and non-diabetes., Hormone Research, 98, 2007, p1007-
H Hoey, The National Children's Hosptial, British Society for the History of Paediatric and Child Health 7th Annual Meeting, RCSI Dublin, September, 2007, British Society for the History of Paediatrics and Child Helath, 12-
H Hoey, C De Beaufort, P Swift, S Skovlund, F Cameron, Association of metabolic control outcomes with adolescent and parent quality of life, Hormone Research, 68, 2007, p25-
S O'Riordan, E Roche, S George, H Hoey, B Elnazir, P Greally, G Canny, C Costigan, D Slattery, N Murphy, Continuous Glucose monitoring Enhances the Detection of Cystic Fibrosis Related Diabetes in Children with Cystic Fibrosis, The Joint Faculty of Paediatrics and Irish Paediatric Association Meeting, Limerick, May, 2007
S O'Connell, E O'Mullane, M Sheridan-Sheridan-Pereira, E Roche, H Hoey, Long-term growth and clinical asssessment of children born small for gestation age., Hormone Research, 68, (Supplemental 1), 2007, ppo1 - 67
S O'Connell, E O'Mullane, H Hoey, Dangers for not treating SGA child, Irish Medical Times, April, 2007
S O'Riordan, S Ennis, A Green, S George, E Hand, C Costigan, E Roche, H Hoey, Genetic Aspects of Cystic fibrosis Related Diabetes, The Joint Faculty of Paediatrics and Irish Paediatric Association Meeting, Limerick, May, 2007
H Hoey, C De Beaufort, P Swift, S Skovlund, F Cameron, Quality of life and family burden in children with cystic fibrosis related diabetes, Hormone Research, 68, 2007, p25-
S O'Connell, E O'Mullane, A Juul, DB Dunger, EF Roche, H Hoey, Auxological characteristics of children born Small for Gestation Age without catch up growth and response to Growth Hormone Treatment, British Society for Paediatric Endocrinology and Diabetes (ESPED), Cambridge, England, September, 2007, BESPED, 29 - 29pp
H Hoey, Overview of Turner Syndrome, Sharing Best Practice in Turner Syndrome, Dublin, November , 2007, The Organisation of Paediatirc Enbdocrine Nurses of Ireland
S O'Connell, E O'Mullane, E Roche, M Sheridan-Pereira, H Hoey, Follow-up Assessment of Children Born Small for Gestational Age at the Coombe Women's Hospital (1999-2001), Irish Perinaltal Society, Belfast, N Ireland, March , 2007
CE De Beaufort, GE Swift, PG Skinner, CT Aanstoot, H Hoey, et at, Continuing stability of center differences in pediatric diabetes care: do advances in diabetes treatment imporve outcome?, Diabetes Care, 30, 2007, p2245 - 2250
S O'Riordan, S George, H Hoey, E Roche, C Hilary, C Costigan J Caffery, C Corridon, E Hand, N Murphy, Dietary assessment of children and adolescents with cystic fibrosis with and without diabetes, Hormone Research, 68, 2007, p111-
H Hoey, P Swift, C De Beaufort, T Skinner, S Skovlund, F Cameron, Parent well-being and support are associated with better metabolic control and quality of life in adolescents with type 1 diabetes, Pediatric Diabetes, 8, 2007, p13-
H Hoey, C deBeaufort, TC Skinner, S Skovlund For the Hidore Study Group on Childhood Diabetes, The association of parent well-being with metabolic control and Quality of Life in adolescents with Type 1 Diabetes, British Society fo Paediatric Endocrinology and Diabetes (BSPED), Cambridge, England, September, 2007, BESPED, 20 - 20pp
S O'Connell, E O'Mullane, M Sheridan-Pereira, E Roche and H Hoey., Long-term growth and clinical assessment of children born small for gestational age. , Hormone Research, 68, (1), 2007, p1-67
S O'Connell, E O'Mullane, H Hoey, Small Babies Risk Health Problems, Irish Medical Times, April, 2007
S O'Riordan, S George, C Costigan, E Roche, H Hoey, Homeostasis and Continuous Glucose Monitoring in CF Childrne, Diabetes UK, March, 2006
H.M.C.V. Hoey, Empowering children with diabetes, Diabetic Medicine, 23, (4), 2006, p6 - 7
S O'Connell, L Doyle, E O'Mullane, E Roche H Hoey, Silver Russell Syndrome (SRS): No distinction between IUGR and SGA when considering Growht Hormone Treatment?, British Society of Paeditarc Endocrinology & Diabetes, Cork, September, 2006
H Hoey, H McGee, M Fitzgerald, H Mortensen, P Hougaard, H Lynggaard, S Skouvlund, Metabolic Control and Quality of life in 2,101 children with Type 1 Diabetes: Development of International Instruments for Assessment of Parent and Health Professional Perspectives, Summer Meeting, Galway, 27 May, 2006, Irish Paediatric Association
Hussey, J., Gormley, J., Bell, C., Roche, E.F., Hoey, H., Exercise tolerance and physical activity levels in children referred to a weight reduction clinic. , Irish Medical Journal, 99, (2), 2006, p46-47
S O'Riordan, H Hoey, S George, C Costigan, Can continuous glucose monitoring (CGMS) enhance the detection of CFRD in 167 Cystic Fibrosis Children?, Diabetes Care, 17, 2006, p17 - 17
S O'Riordan, S George, C Costigan, E Roche, H Hoey, The prevalence of glucose intolerance and diabetes assessed by continuous glucose monitoring sensors in cystic fibrosis children., Royal College of Paediatrics And Child Helath, University of York, April, 2006, British Society for Paediatric Endocrinology and Diabetes
H Hoey, H McGee, M Fitzgerald, H Mortensen, P Hougaard and for the Hvidore Study Group on Childhood Diabetes, Parent and health professional perspectives in the management of adolescents with diabetes: Development of assessment instruments for international studies., Quality of Life Research, 15, (6), 2006, p1033 - 1042
S O'Rioran, S George, C Costigan, E Roche, H Hoey, Can CGMS enhance diagnosis of CFRD in 167 CF Children., American Diabetes Association, Washington DC, June , 2006
S O'Riordan, S George, H Hoey, The Prevalance of Glucose Intolerance and Diabetes Assessed By Continuous Glucose Monitoring Sensors in Childrne with Cystic Fibrosis, Archives of Disease in Childhood, 91, (Supp 1), 2006, pA20 - A20
H Hoey, Adult GH and neuroimaging surveillance, International Growth Monitor, 16, (1), 2006, p27 - 29
H Hoey, H McGee, M Fitzgerald, H Mortensen, P Hougaard, Parent and health professional perspectives in the management of adolescents with diabetes: development of assessment instruments for international studies, Quality of Life Research, 15, (6), 2006, p1033 - 1042
Hvidore Study Group on Childhood Diabetes, TC H McGeeSkinner, H Hoey, A short form of the Diabetes Quality of Life for Youth questionnaire: exploratory and confirmatory analysis in a sample of 2,077 young people with type 1 diabetes mellitus, Diabetologia, 49, (4), 2006, p621 - 628
F Healy, A Brennan, H Fitzgerald, F Cleary, E Roche, H Hoey, Insulin Pump Therapy in Children and Adolescents with Type 1 Diabetes Attending a Tertiary Referral Centre, Proceedings of The Irish and American Paediatric Society 38th Annual Meeting, 2006, pp33 - 33
S ORiordan, H Hoey, S George, C Costigan, Can continus glucose monitoring (CGMS) enhance the detection of CFRD in 167 Cystic Fibrosis Children?, Diabetes Care, 72, (Oral), 2006, pA17-
S O'Riordan, S George, C Costigan, E Roche, H Hoey, The prevalence of IGT and CFRD by continuous glucose monitoring in children with Cystic Fibrosis, Royal College of Paediatrics and Child Health, York, England, April, 2006
S O'Riordan, S George, C Costigan, E Roche, H Hoey, The Prevelence of CFRD in 167 Children, American Diabetes Association, Washington DC, June , 2006
The National Children's Hospital in, editor(s)David Fitzpatrick , The Feds, Dublin, Pub A.&A. Farmer, 2006, pp120 - 129, [Hilary Hoey, Meadhbh O'Leary]
S O'Riordan, S George, C Costigan, E Roche, H Hoey, CGMS in Cystic Fibrosis children, ts this the screening tool we should be using for early detection of CF related Diabestes., ISPAD, 2006
F Healy, A Brennan, H Fitzgerald, F Cleary, H Hoey, Insulin Pump Therapy in Children and Adolescents with Type 1 Diabetes Attending A Tertiary Referral Centre, Summer Meeting, Galway, 27 May, 2006, Irish Paediatric Association
F Healy, A Brennan, H Fitzgerald, F Cleary, E Roche, H Hoey, Insulin Pump Therapy in Children and Adolescents with Type 1 Diabetes Attending a Tertiary Referral Centre, The Irish and American Paediatric Society, Kilkenny, Ireland, September 2006, 2006
J Hussey, J Gormley, C Bell, EF Roche, H Hoey, Exercise Tolerance and Physical Activity Levels in Children Referred to a Weight Reduction Clinic, Irish Medical Journal, 99, (2), 2006, p46 - 47
L Doyle, S O'Connell, EF Roche, H Hoey, Silver Russell Syndrome - The spectrum of Clinical features, growth outcome and moleculare genetics in a study of 9 patients attending a paediatric Endocrinology clinic., Irish Journal of Medical Sciences , 174, (4), 2005, p1 - 71
S O'Riordan, S George, C Costigan, E Roche, H Hoey, Cystic Fibrosis Diabestes and non-diabetes, North American CF Meeting, Baltimore, USA, October , 2005
S O'Riordan, S George, C costigan, E Roche, H Hoey, A Case of Cystic Fibrosis diabetes - diagnostic and management delemmas, The Dublin Endocrine Club, Dublin, December, 2005
S O'Connell, M Sheridan-Pereira, H Hoey, E Roche, Small for gestation age (SGA) children - Childhood growth outcomes and final adult height., Journal of Maternal-Fetal & Neonatal Medicine, 18, (3), 2005, p203-
S O'Connell, E O'Mullane, JP Murphy, EF Roche, M Sheridan-Pereira, H Hoey, Follow of assessment of children born small for gestation age at the Coombe Women's Hospital (1999 - 2001), Irish Journal of Medical Science, 174, (4), 2005, p1 - 71
J Murphy, HMCV Hoey, M Philip, EF Roche, S Macken, P Mayne, D Duff, M O'Keefe, D McShane, E Fogarty, M O'Regan, Guideline for the Medical Management fo Irish Children and Adolescents with Down Syndrome, Irish Medical Journal, 98, (2), 2005, p48 - 52
S O'Connell, H Hoey, M Sheridan-Pereiar, E Roche, E Quinn, N Croasdell, Small for gestational age children who fail to catch up - are the criteria for growth hormone therapy to stringent?, Hormone Research, 64, (Supplemental 1), 2005
S O'Connell, H Hoey, M Sheriden-Pereirs, E Roche, E Quinn, E O'Mullane, The case for individualising treatment with growth hormone therapy in children born small for gestation age (SGA) who fail to catch up., British Society of Paediatric Endocrinology & Diabetes, Bristol, England, November, 2005
S O'Riordan, S George, C Costigan, E Roche, H Hoey, Cystic Fibrosis Diabetes - The Dublin Experience, International Society of Paediatric Adolescence Diabetes (ISPAD), Krakow, 2005, 2005
H Hoey, Empowering chidlen with diabetes and their parents., Diabetes Voice, 49, (Special Issue), 2004, p25 - 27
J Murphy, H Hoey, M Philip, J Meehan, J Harper, P Maine, F McShane, M O'Regan, S Macken, E Roche, Prevalence and Assessment of Mediacl Disorders in Children andAdolescents with Down Syndorme, 8th World Down Syndrome Congress, Singapore, April 2004, 2004
J Murphy, H Hoey, M Philip, A Walsh, D McShane, M O'Regan, E Roche, Hearing Screening Triage in Children with Down's Syndrome using Otoscopy, Trympanometry and Distortion Product Oto Acoustic Emissions (DPOAE)., Archives of Disease in Childhood, 89, (Supplmental), 2004, pA23 - A24
M Parvin, H Hoey, E Roche, C Costigan, Treatment Outcome in Turner Syndrome, Irish Medical Journal, 97, (1), 2004, p12 - 15
H Hoey, E Roche, J Meehan, Cranial MRI scans are indicated in all grils with central precocious puberty, Hospital Doctor of Ireland, 9, (3), 2004, pAbstract-
H Hoey, E Roche, J Meehan, Effect of discontinuation of growth hormone treatment on risk factors for cardiovascular disease in abdolescents born small for gestation age, Hospital Doctor of Ireland, 9, (3), 2004
H Hoey, E Roche, J Meehan, Photography or ophthalomscopy for detection of diabetic retinopathy?, Hospital Doctor of Ireland, 9, (3), 2004, pAbstract-
H Hoey, E Roche, J Meehan, Benefits of long-term GH therapy in Prader-Willi syndrome: a 4 year study, Hospital Doctor of Ireland, 9, (3), 2003, pAbstracts-
B Mackey, M Fitzgerald, H Hoey, A Psycholsocial Study of a Population of Children andAdolescents with Diabetes Mellitus, Families Under Stress, 7, 2003, p57 - 62
H Hoey, Background and methods for evaluating Quality of Life in children and adolescents with diabetes, Acta Bio-Medica, 74, (Suppletmental 1), 2003, p7 - 12
H Hoey, E Roche, J Meehan, Do all prepubertal years of diabetes duration contribute equally to diabetes complications?, Hospital Doctor of Ireland , 9, (3), 2003, pAbstracts-
H Hoey, Primary medical treatment of acromegaly with slow-release octeotide, Internationl Growth Monitor, 13, (3), 2003
H Hoey, E Roche, J Meehan, Safty and effectiveness of insulin pump therapy in childrena nd adolescents with type 1 diabetes, Hosptial Doctor of Ireland, 9, (3), 2003, pAbstract-
R Holl, P Swift, HB Mortensen, P Hougaard, H Hoey, M Kocova, J Aman, Insulin injection regimens and metabolic control in an international survey of adolescents with type 1 diabetes over 3 years: results for the Hvidore study group, European Journal for Paediatrics, 162, 2003, p22 - 29
R Holl, P Swift, H Mortensen, H Hoey, H lynggard, F Chiarelli, H Drochy, P Martelul, M Vanelli, Insulin injection regimens and metabolic control in an internationl survey of adolescents with type 1 diabetes over 3 years: results from the Hvidore study group, European Journal of Pediatrics, 162, 2003, p22 - 29
E Roche, H Lewy, H Hoey, Z Laron, Differences between males and females in the seasonality of birth and month of clinical onset of disease in children with type 1 diabetes mellitus in Ireland, Journal of Pediatric Endocrinology & Metabolism, 16, (5), 2003, p779 - 782
E Roche, A Menon, D Gill, H Hoey, Incidence of Type 1 Diabetes Mellitus in Childrne Ages Under 15 years in the Republic of Ireland, Journal of Paediatric Endocrinology & Methabolism, 15, 2002, p1191 - 1194
E Roche, H Hoey, Presentaiton of Type 1 Diabetes, Journal of Paediatric endocrinology & Metabolism, 15, (S4), 2002, p1087-
P Swift, P Hougaard, R Holl, MB Hortensen, H Hoey, for the Hvidore Study Group on Childhood Diabetes, Standard Bicarbonate Rather Than pH is Associate with continuing Endogenous Insulin Secretion at 12 Months after Onset., Journal of Paediatric Endocrinology & Methabolism , 15, (S4), 2002, p1069-
H B Mortensen, P Houggard, H Hoey, R Holl P Swift, for the Hvidore Study Group on Childhood Diabetes., Residual Insulin Secretion During the First Year After Diagnosis, Journal of Paediatric Endocrinology & Metabolism, 15, 2002, p1191 - 1194
P Swift, P Hougaard, R Holl, MB Hortensen, H Hoey, for the Hvidore Study Group on Childhood Diabetes, Standard Bicarbonate Rather Than kpH is Associate with continuing Endogenous Insulin Secretion at 12 Months after Onset., Journal of Paediatric Endocrinology & Methabolism , 15, (S4), 2002, p1069-
E Roche, A Menon, D Gill, H Hoey, National Incidence of Type 1 Diabetes in Childhood and Adolescence, Irish Medical Journal, 95, (4), 2002, p115 - 118
T Danne, H Mortensen, P hougaard, H Hoey, Presistent differences among centres over 3 yars in glycemic control and hypoglycemia in a study of 3,805 children and adolescents with type 1 diabetes for the Hvidore study group, Diabetes Care, 24, 2001, p1342 - 1347
R Stanhope, C Buchanan, H Hoey, G Butler, C Costigan, D Dunger, S Greene, I Huges, C Kelnar, J Kirk, J Komulaine, M Lowry, J Warner, Open-Label Acceptability Study of Norditropin Simple Xx - A new Liquid Growth Hormone Formulation, Journal of Paediatric Endocrinioology and Metabolism, 14, 2001, p735 - 740
H Hoey, rhIGR-1 treatment of children with GH insensitivity syndrome, International Growth Monitor, 11, 2001, p22 - 24
T Danne, H Mortensen, P Hougaard, H Hoey, Presistent differences among centres over 3 yars in glycemic control and hypoglycemia in a study of 3,805 children and adolescents with type 1 diabetes for the Hvidore study group, Diabetes Care, 24, 2001, p1342 - 1347
S Viash, M McDonald, H Hoey, J Mruphy, J Meehan, M Taylor, Evaluation of Compliance in Children with Asthma, Irish Journal of Medical Science, 2001
H Hoey, The acceptability of a liquid GH formulation with a pen/auto insertion device., Medern Medicine of Ireland, 31, (7), 2001, p20 - 23
H Hoey, H Anastood, F Chiarelli, D Daneman, Good metabolic control is associated with better quality of life in 2,1001 adolescent with type 1 diabetes, Diabetes Care, 24, (11), 2001, p923 - 928
J Harper, J Murphy, M Philip, M O'Regan, E Roche, H Hoey, Growth in Children and Adolescents with Down Syndrome in Ireland aged 3 months to 18 years, Irish Journal of Medical Science, 169, 2000, p348-
H Hoey, H Mortensen, H McGee, M Fitzgerald, P Hougaard, H Lynggaard, Metabolic control and quality of life in 2,101 adolescents with diabetes, Irish Journal of Medical Science, 1, (2), 2000, p65-
V Freeman, H Hoey, M Gibney, Euro-Growth Study Group, Euro-Growht References for body mass index and weight for length, Journal of Paediatric Gastroenterology and Nutrition, 31, (1), 2000, p49 - 59
M Philip, J Murephy, P Mayne, M O'Regan, H Hoey, Hypothyroidism in children and adolescents with Down syndrome, Irish Journal of Medical Science, 1, (2), 2000, p25-
V Freeman, H Hoey, M Gibney, Euro-Growth Gtudy Group, Euro-Growth References for Brest-Fed boys and girls: Influences of Breast-Feeding and solids on growth untill 36 months of age, Journal of Paediatric Gastroenterology and Nutrition, 31, (1), 2000, p60 - 71
S Basheer, C McMahon, D Webb, D Barton, J Poulton, E Treacy, O Smith, H Hoey, A mitochondrial disorder associated with haematological d dysfunction and polyendocrinopathy, Irish Journal of Medical Science, 169, 2000, p344-
J Harper, M Philip, J Murphy, M O'Regan, H Hoey, Growth in Irish children and adolescents with Down syndrome, from 3 months to 18 years, Irish Journal of Medical Science, 1, (2), 2000, p64 - 65
H Hoey, M Mortensen, P Hougarrd, H Lynngaard, Gender differences metabolic control and quality of life in children and adolescents with Type 1 Diabetes, Journal of Paediatrics Endocrinology and Metabolisim, 13, (4), 2000, p1215-
M Philip, J Murphy, P Maine, M O'Regan, H Hoey, Screening for Hypothyroidism inchildren and Adolescents with Down's Syndrome, Archives of Disease in Childhood, 82, 2000, pG38-
M Philip, J Murphy, P Mayne, M O'Regan, H Hoey, Hypothyroidism in children and adolescents with Down syndrome, Irish Journal of Medical Science, 1, (2), 2000, p25-
v Freeman, H Hoey, M Gibney, Euro-Growth Study Group, euro-Growth Study: Why, Who, and How, Journal of Paediatric Gastroenterology and Nutrition, 31, (1), 2000, p3 - 13
V Freeman, H Hoey, M Gibney, Euro-Growth Study Group, Euro-Growth References for Lenght, Weight, and Body Circumferences, Journal of Paediatric Gastroenterology and Nutrition, 31, (1), 2000, p14 - 38
V Freeman, M Van't Hof, F Haschke, H Hoey, M Gibney, and the Euro-Growth Study Group, Patterns of milk and food intake in infants from birth to age 36 months: The Euro-Growth Study, Journal of Paediatric Gastroenterology and Nutrition, 31, (1), 2000, p76 - 85
E Roche, A Menon, D Gill, H Hoey, Family characteristics in Children and Adolescents with new onset Insulin Dependent Diabetes, Irish Journla of Medical Science, 169, 2000, p351-
S Basheer, J Honour, H Hoey, Familial congenital adrenal hypoplasia, Irish Journal of Medical Science, 169, 2000, p344-
J Harper, J Murphy, M Philip, M O'Regan, E Roche, H Hoey, Growth in Children and Adolescents with Down Syndrome in Ireladn aged 3 months to 18 years, Irish Journal of Medical Science, 169, 2000, p348-
E Roche, A Mernon, D Gill, H Hoey, National incidence of Insulin Dependent Diabetes Mellitus in Childhood and Adolescences in 1998, Irish Journal of Medical Science, 169, 2000, p348-
J Murphy, A Walsh, M O'Regan, D McShane, H Hoey, Assessment of hearing function in children and adolescents with Down syndrome, using distortion product to acoustic emissions, irish Journal of Medical Science, 169, 2000, p341-
S Basheer, E Quinn, H Hoey, Rectal Hydrocortisone as an alternative to parental administration in acute management?, Irish Journal of Medical Science, 169, 2000, p343-
v Freeman, H Hoey, M Gibney, Euro-Growht Study Group, Euro-Growth References on Increments in Length, Weight, and Heald and Arm Circumferences during the first 3 years of life., Journal of Paediatric Gastroenterology and Nutrition, 31, (1), 2000, p39 - 47
S El Abd, M Patton, J Turk, H Hoey, P Howlin, Social, communicational, and behavioural deficits associated with ring x Turner syndrome, American Journal of Medical Genetics, 88, (5), 2000, p510 - 516
V Freeman, H Hoey, M Gibney, Euro-Growth Study Group, Euro-Growth Study: Why, Who, and How, Journal of Paediatric Gastroenterology and Nutrition, 31, (1), 2000, p3 - 13
V Freeman, H Hoey, M Gibney, Euro-Growth Gtudy Group, Euro-Growth References for Brest-Feb boys and girls: Influences of Breast-Feeding and solids on growth untill 36 months of age, Journal of Paediatric Gastroenterology and Nutrition, 31, (1), 2000, p60 - 71
E Roche, A Menon, D Gill, H Hoey, National incidence of insulin dependent diabetes mellitus in those aged under 15 years, Irish Journal of medical Science, 1, (2), 2000, p67-
E Roche, A Menon, D Gill, H Hoey, Do Adolescents with new onset diabetes present to adult or paediatric centres?, Irish Journal of Medical Science, 169, 2000, p346-
V Freeman, H Hoey, M Gibney, Euro-Growht Study Group, Euro-Growth References on Increments in Length, Weight, and Head and Arm Circumferences during the first 3 years of life., Journal of Paediatric Gastroenterology and Nutrition, 31, (1), 2000, p39 - 47