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Dr. Lynne Kelly
Research Fellow, Paediatrics

Publications and Further Research Outputs

Peer-Reviewed Publications

O'Dea MI, Kelly L, McKenna E, Melo AM, Ni Bhroin M, Hurley T, Byrne AT, Colleran G, Vavasseur C, El-Khuffash A, Miletin J, Murphy J, Hickey F, Molloy EJ, Dysregulated Monocyte and Neutrophil Functional Phenotype in Infants With Neonatal Encephalopathy Requiring Therapeutic Hypothermia., Frontiers in pediatrics, 2021 Journal Article, 2021 DOI

Lynne A. Kelly, Mary I. O"Dea, Zunera Zareen, Ashanty M. Melo, Ellen McKenna, Tammy Strickland, Victoria Mc Eneaney, Veronica Donoghue, Geraldine Boylan, Deirdre Sweetman, John Butler, Claudine Vavasseur, Jan Miletin, Afif F.El"Khuffash, Luke A.J. O"Neill, John J. O"Leary, Eleanor J. Molloy, Altered Inflammasome activation in Neonatal Encephalopathy persists in Childhood, Clinical & Experimental Immunology, 2021 Journal Article, 2021

Edward Beamer, Mary Isabel O'Dea, Aisling A Garvey, Jonathon Smith, Aida Menéndez-Méndez, Lynne Kelly, Andreea Pave, Sean Quinlan, Mariana Alves, Eva M Jimenez-Mateos, Faming Tian, Eugene Dempsey, Nicholas Dale, Deirdre M Murray, Geraldine B Boylan, Eleanor J Molloy, Tobias Engel , Novel point-of-care diagnostic method for Neonatal Encephalopathy using purine nucleosides, Frontiers in Molecular Neuroscience, 2021 Journal Article, 2021

McKenna E, Mhaonaigh AU, Wubben R, Dwivedi A, Hurley T, Kelly LA, Stevenson NJ, Little MA, Molloy EJ, Neutrophils: Need for Standardized Nomenclature., Frontiers in immunology, 2021 Journal Article, 2021 DOI TARA - Full Text

Ni Bhroin Megan, Kelly Lynn A, Sweetman Deirdre, Aslam Saima, Hurley Tim, Slevin Marie, Murphy John, Byrne Angela T, Colleran Gabrielle, Molloy Eleanor J, Bokde Arun LW, A Comparison of MRI Scoring Systems Predictive Ability for Two-Year Neurodevelopmental Outcome in Neonatal Encephalopathy, SSRN Electronic Journal, 2021 Journal Article, 2021 DOI

Nawal A B Taher, Lynne A Kelly, Alhanouf I Al-Harbi, Mary I O'Dea, Zunera Zareen, Emer Ryan, Eleanor J Molloy, Derek G Doherty, Altered distributions and functions of natural killer T cells and γδ T cells in neonates with neonatal encephalopathy, in school-age children at follow-up, and in children with cerebral palsy, Journal of Neuroimmunology, 2021 Journal Article, 2021

Huggard D, Kelly L, Worrall A, Gallagher G, Fallah L, Yoo LL, McGrane F, Lagan N, .Roche E, Balfe J, Doherty DG, Molloy EJ, Melatonin as an immunomodulator in children with Down syndrome, Pediatric Research, 2021 Journal Article, 2021 DOI TARA - Full Text

D Sweetman, T Strickland, E Isweisi, L Kelly, M Slevin, V Donoghue, J Meehan, GB Boylan, JF Murphy, A El"Khuffash, EJ Molloy, Multi"Organ Dysfunction Scoring in Neonatal Encephalopathy (MODE Score) and Neurodevelopmental Outcomes, Acta Paediatrica, 2021 Journal Article, 2021 DOI

, Gender and Immune Function in Newborn Infants: The Role of Estrogen, Authorea Preprints, 2021 Journal Article, 2021

Sweetman DU, Strickland T, Melo AM, Kelly LA, Onwuneme C, Watson WR, Murphy JFA, Slevin M, Donoghue V, O'Neill A, Molloy EJ., Neonatal Encephalopathy is associated with altered Interleukin-8 and Granulocyte-Macrophage colony-stimulating factor (GMCSF) which correlates with outcomes., Frontiers in Pediatrics, 2021 Journal Article, 2021

Ryan E, Kelly L, Stacey C, Huggard D, Duff E, McCollum D, Leonard A, Boran G, Doherty DR, Bolger T, Molloy EJ., Mild To Severe Traumatic Brain Injury In Children: Altered Cytokines Reflect Severity, 2021 Journal Article, 2021

Zunera Zareen, John Allen, Lynne A. Kelly, Denise McDonald, Deirdre Sweetman, Eleanor J. Molloy, An observational study of sleep in childhood post"neonatal encephalopathy, Acta Paediatrica, 2021 Journal Article, 2021

Dean Huggard, Lynne Kelly, Emer Ryan, Fiona McGrane, Niamh Lagan, Edna Roche, Joanne Balfe, T. Ronan Leahy, Orla Franklin, Derek G. Doherty, Eleanor J. Molloy, Increased systemic inflammation in children with Down syndrome, Cytokine, 127, 2020, p154938 Journal Article, 2020 DOI TARA - Full Text

Zareen Z, Strickland T, Fallah L, McEneaney V, Kelly L, McDonald D, Molloy EJ., Cytokine dysregulation in children with cerebral palsy, Developmental Medicine & Child Neurology, 2020 Journal Article, 2020

Zareen Z, Zareen Z, Strickland T, Eneaney VM, Kelly LA, McDonald D, Sweetman D, Molloy EJ, Cytokine Dysregulation Persists in Childhood Post Neonatal Encephalopathy, 2020 Journal Article, 2020

Sweetman DU, Strickland T, Melo AM, Kelly LA, Onwuneme C, Watson WR, Murphy JFA, Slevin M, Donoghue V, O'Neill A, Molloy EJ, Neonatal Encephalopathy Is Associated With Altered IL-8 and GM-CSF Which Correlates With Outcomes., Frontiers in pediatrics, 2020 Journal Article, 2020

Dietrick B, Molloy E, Massaro AN, Strickland T, Zhu J, Slevin M, Donoghue V, Sweetman D, Kelly L, O'Dea M, McGowan M, Vezina G, Glass P, Vaidya D, Everett AD, Plasma and Cerebrospinal Fluid Candidate Biomarkers of Neonatal Encephalopathy Severity and Neurodevelopmental Outcomes., The Journal of pediatrics, 2020 Journal Article, 2020

Deirdre U. Sweetman, Lynne Kelly, Tim Hurley, Chike Onwuneme, R. William Gordon Watson, John F. A. Murphy, Marie Slevin, Veronica Donoghue, Eleanor J. Molloy, Troponin T correlates with MRI results in neonatal encephalopathy, Acta Paediatrica, 2020 Journal Article, 2020 DOI

O'Dea M, Sweetman D, Bonifacio SL, El-Dib M, Austin T, Molloy EJ, Management of Multi Organ Dysfunction in Neonatal Encephalopathy., Frontiers in pediatrics, 2020 Journal Article, 2020

Omer M, Melo AM, Kelly L, Mac Dermott EJ, Leahy TR, Killeen O, Saugstad OD, Savani RC, Molloy EJ., Emerging Role of the NLRP3 Inflammasome and Interleukin-1ß in Neonates., Neonatology, 117, (5), 2020, p545-554 Journal Article, 2020 DOI

Huggard D, Koay WJ, Kelly L, McGrane F, Ryan E, Lagan N, Roche E, Balfe J, Leahy TR, Franklin O, Moreno-Oliveira A, Melo AM, Doherty DG, Molloy EJ., Altered Toll-Like Receptor Signalling in Children with Down Syndrome., Mediators of inflammation, 2019, 2019, p4068734 Journal Article, 2019 DOI

Sweetman D, Kelly LA, Zareen Z, Nolan B, Murphy J, Boylan G, Donoghue V, Molloy EJ., Coagulation Profiles Are Associated With Early Clinical Outcomes in Neonatal Encephalopathy., Frontiers in pediatrics, 2019 Journal Article, 2019 DOI

, GP191 Dysregulation of the inflammasome in children with Down syndrome, 2019 Journal Article, 2019

, GP98 IL1-$ß$ levels at presentation with paediatric mild traumatic brain injury are higher in children with previous mild traumatic head injuries, 2019 Journal Article, 2019

, GP124 IL1-$ß$ levels at presentation correlate with symptom burden at 2 weeks in paediatric mild traumatic brain injury, 2019 Journal Article, 2019

Tewari P, White C, Kelly L, Pilkington L, Keegan H, D'Arcy T, Toole SO, Sharp L, O'Leary JJ, Martin CM., Clinical performance of the Cobas 4800 HPV test and the Aptima HPV assay in the management of women referred to colposcopy with minor cytological abnormalities., Diagnostic cytopathology, 46, (12), 2018, p987-992 Journal Article, 2018 DOI

Varga N, Mózes J, Keegan H, White C, Kelly L, Pilkington L, Benczik M, Zsuzsanna S, Sobel G, Koiss R, Babarczi E, Nyíri M, Kovács L, Attila S, Kaltenecker B, Géresi A, Kocsis A, O'Leary J, Martin CM, Jeney C., The Value of a Novel Panel of Cervical Cancer Biomarkers for Triage of HPV Positive Patients and for Detecting Disease Progression., Pathology oncology research : POR, 23, (2), 2017, p295-305 Journal Article, 2017 DOI

Varga N, Mózes J, Keegan H, White C, Kelly L, Pilkington L, Benczik M, Zsuzsanna S, Sobel G, Koiss R, Babarczi E, Nyíri M, Kovács L, Attila S, Kaltenecker B, Géresi A, Kocsis A, O'Leary J, Martin CM, Jeney C., The value of a novel panel of cervical cancer biomarkers for triage of HPV positive patients and for detecting disease progression, Pathology & Oncology Research, 2017 Journal Article, 2017 DOI

, Application of Triage Markers for Management of HPV Positive Women Presenting at Colposcopy with Minor Cytological Abnormalities, United States & Canadian Academy of Pathology 105th Annual Meeting, 2016 Journal Article, 2016

Rayman, M.P., Searle, E., Kelly, L., Johnsen, S., Bodman-Smith, K., Bath, S.C., Mao, J., Redman, C.W.G., Effect of selenium on markers of risk of pre-eclampsia in UK pregnant women: A randomised, controlled pilot trial, British Journal of Nutrition, 112, (1), 2014, p99-111 Journal Article, 2014 DOI

Kelly LA, Seidlova-Wuttke D, Wuttke W, O'Leary JJ, Norris LA, Estrogen receptor alpha augments changes in hemostatic gene expression in HepG2 cells treated with estradiol and phytoestrogens. , Phytomedicine , 21, (2), 2014, p155 - 158 Journal Article, 2014 URL

Laios A, Mohamed BM, Kelly L, Flavin R, Finn S, McEvoy L, Gallagher M, Martin C, Sheils O, Ring M, Davies A, Lawson M, Gleeson N, D'Arcy T, d'Adhemar C, Norris L, Langhe R, Saadeh FA, O'Leary JJ, O'Toole SA, Pre-Treatment of Platinum Resistant Ovarian Cancer Cells with an MMP-9/MMP-2 Inhibitor Prior to Cisplatin Enhances Cytotoxicity as Determined by High Content Screening., International journal of molecular sciences, 14, (1), 2013, p2085-103 Journal Article, 2013 TARA - Full Text DOI

Brosnan JF, Sheppard BL, Kelly LA, O'Leary JJ, Norris LA, Norethisterone acetate alters coagulation gene expression in vitro in human cell culture., Thrombosis research, 131, (1), 2013, p72 - 77 Journal Article, 2013 DOI

, Haemostatic and Angiogenic Dysregulation in Preeclampsia, REPRODUCTIVE SCIENCES, 2012 Journal Article, 2012

Lynne Kelly, Shanthi Muttukrishna, Lucy Norris, John Higgins, P10. Placental expression of haemostatic and angiogenic markers in preeclampsia, Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, 1, (3-4), 2011, p277 Journal Article, 2011

Kelly LA, O'Leary JJ, Seidlova-Wuttke D, Wuttke W, Norris LA, Genistein alters coagulation gene expression in ovariectomised rats treated with phytoestrogens, Thrombosis and Haemostasis, 104, (6), 2010, p1083-1289 Journal Article, 2010 TARA - Full Text

Laios A, O'Toole S, Flavin R, Martin C, Kelly L, Ring M, Finn SP, Barrett C, Loda M, Gleeson N, D'Arcy T, McGuinness E, Sheils O, Sheppard B, O' Leary J, Potential role of miR-9 and miR-223 in recurrent ovarian cancer., Molecular cancer, 7, 2008, p35 Journal Article, 2008 DOI

Non-Peer-Reviewed Publications

Phytoestrogens activate the estrogen receptor in HepG2 cells in, Methods in Molecular Biology, 2017, [Kelly, LA] Book Chapter, 2017

Research Expertise

Projects

  • Title
    • GEMINI
  • Summary
    • GEnder and inflaMmatIon In neonatal encephalopathy.
  • Funding Agency
    • NCRC

Keywords

ELISA; FLOW CYTOMETRY; GENDER DIFFERENCES; IMMUNOMODULATION; Inflammasome-mediated inflammation; NEONATES; PAEDIATRICS; PCR