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Dr. Jerome Fennell
Clinical Senior Lecturer, Clinical Microbiology

Publications and Further Research Outputs

Peer-Reviewed Publications

Byrne CJ, Parton T, McWhinney B, Fennell JP, O'Byrne P, Deasy E, Egan S, Enright H, Desmond R, Ryder SA, D'Arcy DM, McHugh J, Roberts JA, Population pharmacokinetics of total and unbound teicoplanin concentrations and dosing simulations in patients with haematological malignancy, Journal of Antimicrobial Chemotherapy, 73, (4), 2018, p995 - 1003 Journal Article, 2018 DOI URL

Kavanagh N, Ryan EJ, Widaa A, Sexton G, Fennell J, O'Rourke S, Cahill KC, Kearney CJ, O'Brien FJ, Kerrigan SW., Staphylococcal Osteomyelitis: Disease Progression, Treatment Challenges, and Future Directions., Clinical Microbiology Reviews, 31, (2), 2018, p1-25 Journal Article, 2018 DOI

Byrne CJ, Roberts JA, McWhinney B, Fennell JP, O'Byrne P, Deasy E, Egan S, Desmond R, Enright H, Ryder SA, D'Arcy DM, McHugh J, Variability in trough total and unbound teicoplanin concentrations and achievement of therapeutic drug monitoring targets in adult patients with haematological malignancy, Antimicrobial Agents and Chemotherapy, 61, (6), 2017, pe02466-16 Journal Article, 2017 TARA - Full Text DOI

Murphy CM, Di Ruscio F, Lynskey M, Collins J, McCullough E, Cosgrave R, McDonnell D, Fennell J, Identification badge lanyards as infection control risk: a cross-sectional observation study with epidemiological analysis, Journal of Hospital Infection, 96, (1), 2017, p63 - 66 Journal Article, 2017

Byrne CJ, Roberts JA, McWhinney B, Ryder SA, Fennell JP, O'Byrne P, Deasy E, Egan S, Desmond R, Enright H, D'Arcy DM, McHugh J, Population pharmacokinetics of teicoplanin and attainment of pharmacokinetic/pharmacodynamic targets in adult patients with haematological malignancy, Clinical Microbiology and Infection, 23, (9), 2017, p674.e7-674.e13 Journal Article, 2017 Handle DOI TARA - Full Text

Gunning H, Taylor G, Smyth A, Mellotte G, Fennell J, Murphy P, Lavin P, Wall C, An Approach to Optimise Therapeutic Vancomycin Dosage in a Haemodialysis Population., Irish Medical Journal, 109, (9), 2016, p465- Journal Article, 2016

O'Kelly F, Kavanagh S, Manecksha R, Thornhill J, Fennell JP, Characteristics of gram-negative urinary tract infections caused by extended spectrum beta lactamases: pivmecillinam as a treatment option within South Dublin, Ireland., BMC Infectious Diseases, 16, (1), 2016, p620- Journal Article, 2016

Byrne CJ, Egan S, Fennell JP, O'Byrne P, Enright H, Deasy E, Ryder SA, D'Arcy DM, McHugh J, Teicoplanin use in adult patients with haematological malignancy: Exploring relationships between dose, trough concentrations, efficacy and nephrotoxicity, International Journal of Antimicrobial Agents, 46, (4), 2015, p406 - 412 Journal Article, 2015 DOI URL URL

Alsinnawi M, Egan S, Groarke E, McCullagh E, Fennell J, Flynn R, McDermott T, Grainger R, Thornhill J., Risk Factors and Significance of Gentamicin Resistant Positive Urine Culture in Patients Undergoing Urological Surgery: A Short Report., Current urology, 8, (4), 2015, p175-177 Journal Article, 2015 DOI

Brown AF, Murphy AG, Lalor SJ, Leech JM, O'Keeffe KM, Mac Aogáin M, O'Halloran DP, Lacey KA, Tavakol M, Hearnden CH, Fitzgerald-Hughes D, Humphreys H, Fennell JP, van Wamel WJ, Foster TJ, Geoghegan JA, Lavelle EC, Rogers TR, McLoughlin RM, Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection., PLoS pathogens, 11, (11), 2015, pe1005226 Journal Article, 2015 TARA - Full Text DOI

Appleby N, Dillon A, Arrigan M, Fennell J, Crowley B, Hayden PJ, Enright H, Symptomatic BK virus reactivation following fludarabine, cyclophosphamide and rituximab chemotherapy for chronic lymphocytic leukemia/small lymphocytic lymphoma., Leukemia and Lymphoma, 55, (5), 2014, p1181 - 1183 Journal Article, 2014

Byrne CJ, Egan S, D'Arcy DM, O'Byrne P, Deasy E, Fennell JP, Enright H, McHugh J, Ryder SA, Teicoplanin usage in adult patients with haematological malignancy in the UK and Ireland: Is there scope for improvement, Eur J Hosp Pharm, 21, (5), 2014, p301 - 305 Journal Article, 2014 URL DOI

Cullen IM, Manecksha RP, McCullagh E, Ahmad S, O'Kelly F, Flynn R, McDermott TE, Murphy P, Grainger R, Fennell JP, Thornhill JA, An 11-year analysis of the prevalent uropathogens and the changing pattern of Escherichia coli antibiotic resistance in 38,530 community urinary tract infections, Dublin 1999-2009., Irish journal of medical science, 182, (1), 2013, p81-9 Journal Article, 2013 DOI

A Cafferkey, J Collins, D Kane, J Gibney, JP Fennell, An Antipodean Infection, Irish Medical Journal, 105, (6), 2012, p125 - 125 Journal Article, 2012

Fennell J, Vellinga A, Hanahoe B, Morris D, Boyle F, Higgins F, Lyons M, O'Connell K, Keady D, Cormican M, Increasing prevalence of ESBL production among Irish clinical Enterobacteriaceae from 2004 to 2008: an observational study., BMC infectious diseases, 12, 2012, p116 Journal Article, 2012

Cullen IM, Manecksha RP, McCullagh E, Ahmad S, O'Kelly F, Flynn RJ, McDermott T, Murphy P, Grainger R, Fennell JP, Thornhill JA, The changing pattern of antimicrobial resistance within 42 033 Escherichia coli isolates from nosocomial, community and urology patient-specific urinary tract infections, Dublin, 1999-2009., BJU international, 109, (8), 2012, p1198-206 Journal Article, 2012 DOI

Daruwalla ZJ, Rowan F, Finnegan M, Fennell J, Neligan M, Exsanguinators and tourniquets: do we need to change our practice?, The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland, 10, (3), 2012, p137-42 Journal Article, 2012

Egan S, Murphy PG, Fennell JP, Kelly S, Hickey M, McLean C, Pate M, Kirke C, Whiriskey A, Wall N, McCullagh E, Murphy J, Delaney T, Using Six Sigma to improve once daily gentamicin dosing and therapeutic drug monitoring performance., BMJ quality & safety, 21, (12), 2012, p1042-51 Journal Article, 2012 DOI

Manecksha RP, Nason GJ, Cullen IM, Fennell JP, McEvoy E, McDermott T, Flynn RJ, Grainger R, Thornhill JA, Prospective study of antibiotic prophylaxis for prostate biopsy involving >1100 men., TheScientificWorldJournal, 2012, 2012, p650858 Journal Article, 2012

Collins CJ, Fraher MH, O'Connell K, Fennell J, FitzGerald SF, O'Sullivan N, Cormican M, Fenelon LE, Murphy P, Hannan MM, Reporting of meticillin-resistant and -susceptible Staphylococcus aureus on death certificates in Irish hospitals., The Journal of hospital infection, 77, (2), 2011, p143-7 Journal Article, 2011

O'Connell K, Fennell J, Callaghan J, Rowaiye B, Cormican M, A fatal case of Pasteurella multocida epiglottitis., Irish journal of medical science, 178, (4), 2009, p541-2 Journal Article, 2009

Fennell JP, O'Donohoe M, Cormican M, Lynch M, Linezolid lock prophylaxis of central venous catheter infection., Journal of medical microbiology, 57, (Pt 4), 2008, p534-5 Journal Article, 2008

Charalampidou S, Connell P, Fennell J, Lynch M, Acheson R, Preseptal cellulitis caused by community acquired methicillin resistant Staphylococcus aureus (CAMRSA)., The British journal of ophthalmology, 91, (12), 2007, p1723-4 Journal Article, 2007

Fennell JP, Brosnan MJ, Frater AJ, Hamilton CA, Alexander MY, Nicklin SA, Heistad DD, Baker AH, Dominiczak AF, Adenovirus-mediated overexpression of extracellular superoxide dismutase improves endothelial dysfunction in a rat model of hypertension., Gene therapy, 9, (2), 2002, p110-7 Journal Article, 2002

Jerome Patrick Fennell, Adenoviral-mediated vascular gene transfer: a strategy to manipulate the nitric oxide/superoxide pathway, University of Glasgow, 2002 Thesis, 2002 URL

Berry C, Brosnan MJ, Fennell J, Hamilton CA, Dominiczak AF, Oxidative stress and vascular damage in hypertension., Current opinion in nephrology and hypertension, 10, (2), 2001, p247-55 Journal Article, 2001

Alexander MY, Brosnan MJ, Hamilton CA, Fennell JP, Beattie EC, Jardine E, Heistad DD, Dominiczak AF, Gene transfer of endothelial nitric oxide synthase but not Cu/Zn superoxide dismutase restores nitric oxide availability in the SHRSP., Cardiovascular research, 47, (3), 2000, p609-17 Journal Article, 2000

Non-Peer-Reviewed Publications

Una Sutton Fitzpatrick, Judi Lynch, Niamh Fitzgerald, Guerrino Macori, Séamus Fanning, Jérôme Fennell, SARS-CoV2 Reinfections in a University Teaching Hospital, IDWeek, Online, Sep 29-Oct 3 2021, 2021 Oral Presentation, 2021

Carton M, Wall N, Prior A-R, Fennell J, Frost S, You can't fight what you don't find: Carbapenemase-producing Enterobacterales Screening in Tallaght University Hospital, ISCM Spring Meeting, Dublin, March 2019, 2019 Poster, 2019

Sadhbh O'Rourke, Corinne Binions, Niall Wall, Dympna McDonnell, Anna-Rose Prior, Susanna Frost, Jérôme Fennell, Timing of conversion to positivity of carbapenemase-producing Enterobacteriaceae contacts during a tertiary hospital OXA-48 outbreak., Federation of Infection Societies (FIS) Annual Conference, Birmingham, UK, 30 November 2017, 2017 Poster, 2017 URL

D Ryan, R Connolly, J Fennell, G Fitzpatrick, Aetiology of community-acquired pneumonia in the ICU setting and its effect on mortality, length of mechanical ventilation and length of ICU stay: a 1-year retrospective review, Critical Care, Sepsis, Paris, France, Dec 2014, 18, (2), BioMed Central, 2014, pp45 - 45 Poster, 2014 URL

Galvin M, Fennell J, Antimicrobial stewardship rounds in a general hospital in Ireland, INTERNATIONAL JOURNAL OF CLINICAL PHARMACY, 34, (5), 2012, pp788 - 789 Conference Paper, 2012

Fennell J, Hanahoe B, Higgins F, Lyons M, O'Connell K, Boyle F, Morris D, Corbett-Feeney G, Keady D, Cormican M, Increasing Frequency of Detection of Extended-Spectrum Beta-Lactamases in Ireland, Federation of Infection Societies, Cardiff, UK, 2008, 2008 Poster, 2008 URL

Fennell J, Locked and Boweled Over, Ehrlich II, Nurnberg, Germany, Oct 2008, 2008 Poster, 2008

Fennell J, Smoking, Sputum and Streptococci, Ehrlich II, Nurnberg, germany, Oct 2008, 2008 Poster, 2008

JEROME P. FENNELL, CIARA A. KIRKE, JAMES J. EGAN, JOHN P. HURLEY, JAMES F. MCCARTHY, MARGARET M. HANNAN, , Risk Factors for Invasive Aspergillosis Among Heart Transplant Recipients in Ireland, Infectious Diseases Society of America Annual Meeting, Washington DC, USA, 2006, Infectious Disease Society of America, 2006 Meeting Abstract, 2006

Fennell JP, Baker AH, Hypertension: Methods & Protocols, , 1, Humana Press, 2005, 1 - 502pp Book, 2005

Gene therapy for hypertension: Future or fiction? in, editor(s)P.A.F.M. Doevendans, Stefan Kääb , Cardiovascular Genomics: New Pathophysiological Concepts, KLUWER ACADEMIC PUBLISHERS, 2002, pp65 - 75, [JP Fennell, MJ Brosnan, AJ Frater, AH Baker, AF Dominiczak] Book Chapter, 2002

MJ Brosnan, CA Hamilton, JP Fennell, AJ Frater, AH Baker, AF Dominiczak, Pharmacological attenuation of superoxide improves endothelial function in spontaneously stroke prone rats, JOURNAL OF HYPERTENSION, 20, 2002, ppS107 - S107 Meeting Abstract, 2002

M Brosnan, C Hamilton, J Fennell, A Baker, M Alexander, D Hersrad, A Dominiczak, Gene transfer of human endothelial nitric oxide synthase and human superoxide dismutase to improve endothelial function in the SHRSP, JOURNAL OF HYPERTENSION, JOURNAL OF HYPERTENSION, 2000, LIPPINCOTT WILLIAMS & WILKINS, 2000, ppS211- Poster, 2000

Alexander, M Y; Brosnan, M J; Hamilton, C A; Fennell, J P; Prentice, H M; O'Brien, T; Dominiczak, A F., Restoration of nitric oxide bioavailability in the SHRSP model using adenoviral-mediated gene transfer of endothelial nitric oxide synthase into an intact endothelium., Hypertension, 53rd Annual Fall Conference and Scientific Sessions of the American Heart Association, Orlando, Florida, Sep 1999, 34, (2), American Heart Association, 1999, pp352- Poster, 1999

Fennell, J P; Alexander, M Y; Brosnan, M J; Hamilton, C A; Dominiczak, A F., Adenoviral gene transfer in human veins and a model of essential hypertension., Hypertension, 53rd Annual Fall Conference and Scientific Sessions of the American Heart Association, Orlando, Florida, Sep 1999, 34, (4), American Heart Association, 1999, pp700 - 700 Poster, 1999

MY Alexander, MJ Brosnan, J Fennell, AM Devlin, CA Hamilton, AF Dominiczak, A Gene Transfer Strategy to Manipulate Nitric Oxide in the Vasculature of a Hypertensive Rat Model , Biochemical Society Transactions, Biochemical Society Meeting, Birmingham, UK, 20 July 1999, 27, (5), Biochemical Society, 1999, pp149- Poster, 1999 URL

Research Expertise

Description

My research interests include: - the epidemiology of gram negative resistance particularly Carbapenemase producing Enterobacterales (CPE) and Extended spectrum beta-lactamase producers (ESBLs) - The treatment of urinary tract infections caused by resistant Enterobacterales. - Treatment of Staphylococcus aureus infections particularly infections of bone. - Interested in examining the infection prevention benefits of IT solutions such as ICNet for infection prevention and in surgical site infection surveillance. - The epidemiology and infection prevention implications of SARS CoV2 reinfections. - Currently examining requirements to commence on-site genome sequencing for better epidemiological understanding of both SARS CoV2 and CPE outbreaks.

Projects

  • Title
    • Clinical, laboratory and radiological characteristics as predictors of outcome in patients with Covid 19
  • Summary
    • Prospective interdepartmental study examining clinical features, laboratory and radiology tests of patients with SARS-CoV-2 Infection to identify predictors of disease severity, mortality and treatment response.
  • Funding Agency
    • None
  • Date From
    • 2020

Keywords

ENTEROBACTERIACEAE; Extended Spectrum Beta-Lactamases; INFECTION; INFECTION CONTROL; OXA-48; STAPHYLOCOCCUS AUREUS

Recognition

Representations

Representative of the Irish Society of Clinical Microbiologists on the CPE Expert group which advised the NPHET on CPE 2017

Representative of the Irish Society of Clinical Microbiologists for the National Clinical Effectiveness Committee's National Infection Control Guideline Development Group 2017

Awards and Honours

Nominated for Tallaght University Hospital Hero award Oct 2020

Irish Society of Clinical Microbiologists Prize, ISCM Meeting 2008

Young Investigator's Prize, IAS 2001

Memberships

Member of the Irish Society of Clinical Microbiologists 2002 – Present

Member of the British Infection Association/British Infection Society 2005 – Present

Member of the European Society of Clinical Microbiology and Infectious Diseases 2003 – Present

Fellow of the Royal College of Pathology, UK 2008 – Present

Fellow of the Faculty of Pathology, Royal College of Physicians of Ireland 2010 – Present

Fellow of the Royal College of Physicians of Ireland 2020 – Present

Elected to Executive Committee of the Irish Society for Gene and Cell Therapy 2008 – 2009